Antibody data

Product number
BS6789
Provider
Bioworld Technology, Inc
Product name
MALT1 polyclonal antibody
Provider product page
Bioworld Technology, Inc - BS6789
Antibody type
Polyclonal
Antigen
Recombinant full length Human MALT1.
Description
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21.32, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. The MALT1-API2 fusion protein activates NF?B and creates a signaling pathway, which is influenced by this Bcl10-MALT1 complex. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Provider Type Product Number
- No reagents -