14480-1-AP

antibody from Proteintech Group

Targeting: TFE3 bHLHe33, TFEA

Provider product page for 14480-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
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Validations
Western blot [1]

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Product number: 14480-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14480-1-AP, RRID:AB_2199587
Product name: TFE3 antibody
Antibody type: Polyclonal
Description: TFE3 antibody (Cat. #14480-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TFE3 protein structure - 14480-1-AP shown in red.

Submitted references S100A11 regulates microglial inflammatory response in neuropathic pain via H3K27ac-TFEB-mitochondrial autophagy axis.

Zheng H, Tian S, Wu L, Jia G, Xiao Y, Yu X, Zuo Q, Zhou R, Min J, Wu Q, Xie H, Luo Q, Wu W
The journal of headache and pain 2026 Mar 11;27(1)

Antiviral Activity of Microbial Metabolites Monensin and Brefeldin A Against Toscana Virus: In Vitro Evaluation and Mechanistic Insights.

Di Clemente L, Zannella C, Palma F, Acunzo M, Giugliano R, Chianese A, Bonura F, De Grazia S, Giammanco GM, De Filippis A, Galdiero M
Viruses 2026 Feb 27;18(3)

Stimulation to secrete insulin induces pancreatic β-cell dysfunction through Tfe3 activation.

Aida Y, Kadota N, Takahashi M, Koshiishi Y, Kasahara K, Kataoka K
iScience 2026 Apr 17;29(4):115312

Fenofibrate suppresses Mycoplasma bovis infection via autophagy-mediated cholesterol regulation in bovine mammary epithelial cells and murine mammary tissue.

Xu M, Wang T, Deng X, Liu Y, Zhu Z, Barkema HW, Cobo ER, Kastelic JP, Zhou X, Han B
Frontiers in cellular and infection microbiology 2025;15:1731492

LGI3 promotes the progression of TFE3-rearranged renal cell carcinoma through GEMIN6/AURKB axis.

Liu J, Feng H, Xiong Z, Cao S, Cai T, Wei W, Tao W, Zhang X, Ma X, Li X
Oncogene 2025 Oct;44(39):3729-3740

TGF-β2 increases eHSP90α secretion via upregulating secretory autophagy pathway.

Li J, Li J, Xie T, Huang S, Tian H, Liu M, Kong X, Zhang D, Nawaz KI, Wang M, Li H, Zhang J, Yuan F, Guo W, Cui X, Mu H, Hu Y
Cell communication and signaling : CCS 2025 Nov 12;23(1):492

The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA.

Leib L, Juli J, Jurida L, Mayr-Buro C, Priester J, Weiser H, Wirth S, Hanel S, Heylmann D, Weber A, Schmitz ML, Papantonis A, Bartkuhn M, Wilhelm J, Linne U, Meier-Soelch J, Kracht M
EMBO reports 2025 Feb;26(4):1144-1183

Lysosomal catabolic activity promotes the exit of murine totipotent 2-cell state by silencing early-embryonic retrotransposons.

Wu H, Cao L, Wen X, Fan J, Wang Y, Hu H, Ji S, Zhang Y, Ye C, Xie W, Zhang J, Xu H, Fu X
Developmental cell 2025 Feb 24;60(4):512-523.e7

Newcastle disease virus induces degradation of folliculin to regulate host cell energy metabolism and facilitate viral replication.

Yang M, Kan X, Li X, Sun Y, Liao Y, Qiu X, Tan L, Song C, Ding C
Poultry science 2025 Aug;104(8):105314

Flotillin-1 promotes the progression of hepatocellular carcinoma by activating TFE3-mediated Golgi stress response via inhibition of mTORC1/2.

Zhang L, Bai CZ, Shan JY, Xue HL, Zheng SM, Chen YL, Tang SH
World journal of gastroenterology 2025 Aug 7;31(29):106895

NMRK2 is an efficient diagnostic indicator for Xp11.2 translocation renal cell carcinoma.

Feng H, Cao S, Fu S, Liu J, Gao Y, Dong Z, Cai T, Wen L, Xiong Z, Li S, Zhang X, Ma X, Li X
The Journal of pathology 2024 Oct;264(2):228-240

CDK4/6 Inhibitors Impede Chemoresistance and Inhibit Tumor Growth of Small Cell Lung Cancer.

Wen Y, Sun X, Zeng L, Liang S, Li D, Chen X, Zeng F, Zhang C, Wang Q, Zhong Q, Deng L, Guo L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2400666

TFE3-SLC36A1 axis promotes resistance to glucose starvation in kidney cancer cells.

Lv S, Zhang Z, Li Z, Ke Q, Ma X, Li N, Zhao X, Zou Q, Sun L, Song T
The Journal of biological chemistry 2024 May;300(5):107270

Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress.

Wang YY, Ni JC, Zhao YQ, Yang X, Niu ZP, Yang XZ, Dong XX, Zhao YH, Hao XJ, Ding X
Journal of Asian natural products research 2024 May;26(5):562-574

ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells.

Koh M, Lim H, Jin H, Kim M, Hong Y, Hwang YK, Woo Y, Kim ES, Kim SY, Kim KM, Lim HK, Jung J, Kang S, Park B, Lee HB, Han W, Lee MS, Moon A
Autophagy 2024 Mar;20(3):659-674

Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress.

Liu C, Xu Y, Yang G, Tao Y, Chang J, Wang S, Cheung TH, Chen J, Zeng YA
Cell stem cell 2024 Jan 4;31(1):89-105.e6

Regulation of Benzo[a]pyrene-Induced Hepatic Lipid Accumulation through CYP1B1-Induced mTOR-Mediated Lipophagy.

Bu KB, Kim M, Shin MK, Lee SH, Sung JS
International journal of molecular sciences 2024 Jan 22;25(2)

Patient-derived Induced Pluripotent Stem Cells as a Model to Study Frontotemporal Dementia Pathologies.

Infante-Tadeo S, Barber DL
bioRxiv : the preprint server for biology 2024 Dec 17;

Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.

Liang H, Luo R, Li G, Zhang W, Zhu D, Wu D, Zhou X, Tong B, Wang B, Feng X, Wang K, Song Y, Yang C
Cell death and differentiation 2023 Sep;30(9):2135-2150

TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.

Chae CW, Yoon JH, Lim JR, Park JY, Cho JH, Jung YH, Choi GE, Lee HJ, Han HJ
Autophagy 2023 Oct;19(10):2752-2768

TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy.

Song T, Lv S, Ma X, Zhao X, Fan L, Zou Q, Li N, Yan Y, Zhang W, Sun L
The Journal of biological chemistry 2023 May;299(5):104621

The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis.

Ong AJS, Bladen CE, Tigani TA, Karamalakis AP, Evason KJ, Brown KK, Cox AG
Proceedings of the National Academy of Sciences of the United States of America 2023 May 30;120(22):e2217425120

TFE3-mediated impairment of lysosomal biogenesis and defective autophagy contribute to fluoride-induced hepatotoxicity.

Hu Z, Xu W, Zhang J, Tang Y, Xing H, Xu P, Ma Y, Niu Q
Ecotoxicology and environmental safety 2023 Mar 15;253:114674

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.

Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr
Nature communications 2022 Oct 7;13(1):5924

Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm.

Jia Y, Zhang L, Liu Z, Mao C, Ma Z, Li W, Yu F, Wang Y, Huang Y, Zhang W, Zheng J, Wang X, Xu Q, Zhang J, Feng W, Yun C, Liu C, Sun J, Fu Y, Cui Q, Kong W
Cell discovery 2022 Mar 1;8(1):21

The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome in hepatocellular carcinoma.

Ferro I, Gavini J, Gallo S, Bracher L, Landolfo M, Candinas D, Stroka DM, Polacek N
Autophagy 2022 Jan;18(1):191-203

PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma.

Wang B, Yin X, Gan W, Pan F, Li S, Xiang Z, Han X, Li D
Autophagy 2021 Sep;17(9):2475-2493

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.

Wang H, Wang N, Xu D, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM, Wang G, Ying Z
Autophagy 2020 Sep;16(9):1683-1696

Anti-cancer effect of marchantin C via inducing lung cancer cellular senescence associated with less secretory phenotype.

Zhang XL, Ji XT, Sun B, Qian LL, Hu XL, Lou HX, Yuan HQ
Biochimica et biophysica acta. General subjects 2019 Oct;1863(10):1443-1457

Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity.

Li S, Niu H, Qiao Y, Zhu R, Sun Y, Ren Z, Yuan H, Gao Y, Li Y, Chen W, Zhou J, Lou H
Bioorganic & medicinal chemistry 2018 May 15;26(9):2392-2400

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TFE3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TFE3. This antibody recognizes human, mouse, rat antigen. The TFE3 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14480-1-AP.pdf

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