Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS2869 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CRF (R153) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 121-170 of Human CRF.
- Description
- Individuals suffering from Alzheimer£ªs disease (AD) exhibit dramatic reductions in the content of corticotropin-releasing factor (CRF), increased expression of CRF receptors (CRFRs) and abnormalities in neuronal morphology in affected brain areas. In addition, AD patients show decreased concentrations of CRF in their cerebrospinal fluid, which may contribute to their cognitive impairment. A high affinity CRF binding protein, designated CRF-BP, has been discovered in post-mortem brain samples from AD patients. CRF-BP serves to bind and inactivate CRF, reducing the pool of ¡ùfree CRF¡ì available to bind CRFRs. Two CRFRs, designated CRF-RI and CFR-RII, have been described and exhibit distinct brain localizations.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of CRF (R153) pAb at 1:500 dilutionLane1:MCF-7 cell lysateLane2:Mouse spleen tissue lysateLane3:Rat spleen tissue lysate