AGTO-L007R

antibody from Creative Biolabs

Targeting: CRH CRF, CRH1

No application information provided.

Antibody Data

Product number

AGTO-L007R

Provider

Creative Biolabs

Product name

anti-CRH immunotoxin PFU 83 (IgG)-RTA

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-CRH monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CRF neurons cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Anorexia nervosa.

Reactivity

Human

Host

Rat