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- References [181]
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- Product number
- 66146-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- IL-6 antibody
- Antibody type
- Monoclonal
- Description
- IL-6 antibody (Cat. #66146-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1A3B4
- Vial size
- 20ul, 150ul
Submitted references Fibroblasts facilitate lymphatic vessel formation in transplanted heart.
Mediation of FOXA2/IL-6/IL-6R/STAT3 signaling pathway mediates benzo[a]pyrene-induced airway epithelial mesenchymal transformation in asthma.
Exploring the efficacy and mechanism of Bailing capsule to improve polycystic ovary syndrome in mice based on intestinal-derived LPS-TLR4 pathway.
The association between endothelial function and autoimmune thyroiditis induced by iodine excess.
Mechanic study based on untargeted metabolomics of Pi-pa-run-fei-tang on pepper combined with ammonia induced chronic cough model mice.
Adipocyte-released adipomes in Chagas cardiomyopathy: Impact on cardiac metabolic and immune regulation.
The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice.
ZeXieYin formula alleviates atherosclerosis by inhibiting the MAPK/NF-κB signaling pathway in APOE-/- mice to attenuate vascular inflammation and increase plaque stability.
A bioenergetically-active ploy (glycerol sebacate)-based multiblock hydrogel improved diabetic wound healing through revitalizing mitochondrial metabolism.
Macrophage ATG16L1 expression suppresses metabolic dysfunction-associated steatohepatitis progression by promoting lipophagy.
Artificial aging conditions for Artemisia argyi leaves based on quality-inflammation-quality marker transformation.
CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis.
FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-κB signaling pathway.
The SGLT2 inhibitor empagliflozin attenuates atherosclerosis progression by inducing autophagy.
Wound microenvironment-responsive dually cross-linked nanofibrillar peptide hydrogels for efficient hemostatic control and multi-faceted wound management.
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Calcitonin gene-related peptide attenuated discogenic low back pain in rats possibly via inhibiting microglia activation.
Microbiome analysis reveals the inducing effect of Pseudomonas on prostatic hyperplasia via activating NF-κB signalling.
Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome.
Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury.
C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways.
Topical Delivery of ROS-Responsive Methotrexate Prodrug Nanoassemblies by a Dissolvable Microneedle Patch for Psoriasis Therapy.
Zhoushi Qiling decoction inhibits proliferation of human prostate cancer cells through IL6/STAT3 pathway.
Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD(+)/SIRT1 axis.
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8.
Neurovascular protection of alisol A on cerebral ischemia mice through activating the AKT/GSK3β pathway.
Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice.
Exploring the therapeutic potential of a nano micelle containing a carbon monoxide-releasing molecule for metabolic-associated fatty liver disease by modulating hypoxia-inducible factor-1α.
Angiogenesis, hemocompatibility and bactericidal effect of bioactive natural polymer-based bilayer adhesive skin substitute for infected burned wound healing.
Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.
FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.
Jiawei Yanghe Decoction suppresses breast cancer by regulating immune responses via JAK2/STAT3 signaling pathway.
Histone methyltransferase KMT2D promotes prostate cancer progression through paracrine IL-6 signaling.
Determination of the optimal concentration and duration of C5aR antagonist application in an inflammatory model of human dental pulp cells.
Protective effect of HDACIs in improves survival and organ injury after CLP-induced sepsis.
Apigenin Inhibits the Progression of Osteoarthritis by Mediating Macrophage Polarization.
Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice.
Increased Cellular Expression of Interleukin-6 in Patients With Ossification of the Posterior Longitudinal Ligament.
Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis.
Simultaneous neutralization of TGF-β and IL-6 attenuates Staphylococcus aureus-induced arthritic inflammation through differential modulation of splenic and synovial macrophages.
Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis.
Gegen-Qinlian decoction alleviates anxiety-like behaviors in methamphetamine-withdrawn mice by regulating Akkermansia and metabolism in the colon.
A COMPARATIVE ANALYSIS TO DETERMINE THE OPTIMUM HISTONE DEACETYLASE INHIBITORS AND ADMINISTRATION ROUTE FOR IMPROVING SURVIVAL AND ORGAN INJURY IN RATS AFTER HEMORRHAGIC SHOCK.
Inflammatory mechanisms of Ginkgo Biloba extract in improving memory functions through lncRNA-COX2/NF-κB pathway in mice with status epilepticus.
Treat the "Untreatable" by a Photothermal Agent: Triggering Heat and Immunological Responses for Rabies Virus Inactivation.
Susceptibility of Fat Tissue to SARS-CoV-2 Infection in Female hACE2 Mouse Model.
Single-cell profiling reveals mechanisms of uncontrolled inflammation and glycolysis in decidual stromal cell subtypes in recurrent miscarriage.
Diets Differently Regulate Tumorigenesis in Young E0771 Syngeneic Breast Cancer Mouse Model.
Metformin Directly Binds to MMP-9 to Improve Plaque Stability.
Diets Differently Regulate Pulmonary Pathogenesis and Immune Signaling in Mice during Acute and Chronic Mycobacterium tuberculosis Infection.
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Crocetin confers neuroprotection and is anti-inflammatory in rats with induced glaucoma.
Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization.
Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway.
Tunicamycin induces depression-like behaviors in male rats, accompanied by initiated chaperon-mediated autophagy and decreased synaptic protein expression in the hippocampus.
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma.
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization.
Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease.
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation.
Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition.
Development of a method to identify persistent and blanchable redness by skin blotting in mice.
A stress-induced cilium-to-PML-NB route drives senescence initiation.
Patchouli alcohol ameliorates depression-like behaviors through inhibiting NLRP3-mediated neuroinflammation in male stress-exposed mice.
Sex Differences in Cardiac Pathology of SARS-CoV2 Infected and Trypanosoma cruzi Co-infected Mice.
Dietary camellia seed oil attenuates liver injury in mice chronically exposed to alcohol.
Atractylodes lancea Rhizoma Attenuates DSS-Induced Colitis by Regulating Intestinal Flora and Metabolites.
Long Noncoding RNA ENSG00000254693 Promotes Diabetic Kidney Disease via Interacting with HuR.
ETC-1002 Attenuates Porphyromonas gingivalis Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells via the AMPK/NF-κB Pathway and Exerts Ameliorative Effects in Experimental Periodontitis in Mice.
BNTA alleviates inflammatory osteolysis by the SOD mediated anti-oxidation and anti-inflammation effect on inhibiting osteoclastogenesis.
Neddylation Inhibition Causes Impaired Mouse Embryo Quality and Blastocyst Hatching Failure Through Elevated Oxidative Stress and Reduced IL-1β.
Neutrophil Extracellular Traps Regulate HMGB1 Translocation and Kupffer Cell M1 Polarization During Acute Liver Transplantation Rejection.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
FumDSB can alleviate the inflammatory response induced by fumonisin B(1) in growing pigs.
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
P2Y(14) receptor in trigeminal ganglion contributes to neuropathic pain in mice.
Cold exposure-induced endoplasmic reticulum stress regulates autophagy through the SIRT2/FoxO1 signaling pathway.
Schisandrol B protects against cholestatic liver injury by inhibiting pyroptosis through pregnane X receptor.
miR-126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis-associated colorectal cancer.
Honokiol alleviates ulcerative colitis by targeting PPAR-γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro.
Transcriptomic Analysis Reveals Lactobacillus reuteri Alleviating Alcohol-Induced Liver Injury in Mice by Enhancing the Farnesoid X Receptor Signaling Pathway.
Multipronged Micelles-Hydrogel for Targeted and Prolonged Drug Delivery in Chronic Wound Infections.
Toll-like receptor 4 deficiency alleviates lipopolysaccharide-induced intestinal barrier dysfunction.
Blockade of Kv1.3 Potassium Channel Inhibits Microglia-Mediated Neuroinflammation in Epilepsy.
Empagliflozin inhibits macrophage inflammation through AMPK signaling pathway and plays an anti-atherosclerosis role.
Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages.
LncRNA SOX2OT facilitates LPS-induced inflammatory injury by regulating intercellular adhesion molecule 1 (ICAM1) via sponging miR-215-5p.
Nanoformulation of a carbon monoxide releasing molecule protects against cyclosporin A-induced nephrotoxicity and renal fibrosis via the suppression of the NLRP3 inflammasome mediated TGF-β/Smad pathway.
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
Association between Incidental Pelvic Inflammation and Aggressive Prostate Cancer.
Curcumin Derivative C66 Suppresses Pancreatic Cancer Progression through the Inhibition of JNK-Mediated Inflammation.
Interleukin-4 activates the PI3K/AKT signaling to promote apoptosis and inhibit the proliferation of granulosa cells.
Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell pyroptosis, and inflammatory bowel disease in mice.
Insulin-incubated palladium clusters promote recovery after brain injury.
Flavokawain B alleviates LPS-induced acute lung injury via targeting myeloid differentiation factor 2.
Construction and comprehensive analysis of a lncRNA-mRNA interactive network to reveal a potential lncRNA for hepatic encephalopathy development.
IL-17A drives cognitive aging probably via inducing neuroinflammation and theta oscillation disruption in the hippocampus.
Synthesis and biological evaluation of novel schisanhenol derivatives as potential hepatoprotective agents.
Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection.
tRNA-derived fragment TRF365 regulates the metabolism of anterior cruciate ligament cells by targeting IKBKB.
Sodium butyrate alleviates pre-eclampsia in pregnant rats by improving the gut microbiota and short-chain fatty acid metabolites production.
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Cytokine Profile From the Ligamentum Flavum in Patients with Ossification of the Posterior Longitudinal Ligament in the Cervical Spine.
The miR-26a-5p/IL-6 axis alleviates sepsis-induced acute kidney injury by inhibiting renal inflammation.
Yanghe decoction attenuated pain hypersensitivity induced by michigan cancer foundation-7 injection in rats with bone metastases from breast cancer by inhibiting transient receptor potential ankyrin 1.
A Multicenter, Single-Blind, Case-Control, Immunohistochemical Study of Orbital Tissue in Thyroid Eye Disease.
Endogenous neutralization of TGF-β and IL-6 ameliorates septic arthritis by altering RANKL/OPG interaction in lymphocytes.
PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6.
Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.
l-Arginine prevents 4-hydroxy-2-nonenal accumulation and depresses inflammation via inhibiting NF-κB activation.
Adropin Carried by Reactive Oxygen Species-Responsive Nanocapsules Ameliorates Renal Lipid Toxicity in Diabetic Mice.
Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer's disease.
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Atractylenolide-1 targets SPHK1 and B4GALT2 to regulate intestinal metabolism and flora composition to improve inflammation in mice with colitis.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Tetrastigma hemsleyanum Diels et Gilg ameliorates lipopolysaccharide induced sepsis via repairing the intestinal mucosal barrier.
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
The Transcription Factor C/EBPβ Promotes HFL-1 Cell Migration, Proliferation, and Inflammation by Activating lncRNA HAS2-AS1 in Hypoxia.
The mechanism and candidate compounds of aged citrus peel (chenpi) preventing chronic obstructive pulmonary disease and its progression to lung cancer.
PAK1 Silencing Attenuated Proinflammatory Macrophage Activation and Foam Cell Formation by Increasing PPARγ Expression.
TLR4-NLRP3-GSDMD-Mediated Pyroptosis Plays an Important Role in Aggravated Liver Injury of CD38(-/-) Sepsis Mice.
Chlorogenic Acid Alleviates Colon Mucosal Damage Induced by a High-Fat Diet via Gut Microflora Adjustment to Increase Short-Chain Fatty Acid Accumulation in Rats.
Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway.
Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways.
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.
Atractylodin Attenuates Dextran Sulfate Sodium-Induced Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting Inflammatory Response Through the MAPK Pathway.
SARS-CoV-2 Accessory Protein ORF7b Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Cells.
miR-23a-3p regulates the inflammatory response and fibrosis in diabetic kidney disease by targeting early growth response 1.
Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury.
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.
A novel indazole derivative, compound Cyy-272, attenuates LPS-induced acute lung injury by inhibiting JNK phosphorylation.
Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis.
EGCG promotes PRKCA expression to alleviate LPS-induced acute lung injury and inflammatory response.
Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1.
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D.
Damage to the blood‑brain barrier and activation of neuroinflammation by focal cerebral ischemia under hyperglycemic condition.
Suppression of adenosine A(2a) receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide-induced cystitis by inhibiting TRPV1.
Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions.
Mesenchymal stem cell-derived exosome miR-542-3p suppresses inflammation and prevents cerebral infarction.
Polystyrene microplastics induced male reproductive toxicity in mice.
Dmrt1 regulates the immune response by repressing the TLR4 signaling pathway in goat male germline stem cells.
Macrophages enhance lipopolysaccharide induced apoptosis via Ang1 and NF-κB pathways in human umbilical vein endothelial cells.
Integrative transcriptomic and metabonomic profiling analyses reveal the molecular mechanism of Chinese traditional medicine huankuile suspension on TNBS-induced ulcerative colitis.
Cardamonin inhibits LPS-induced inflammatory responses and prevents acute lung injury by targeting myeloid differentiation factor 2.
Links Between Gut Dysbiosis and Neurotransmitter Disturbance in Chronic Restraint Stress-Induced Depressive Behaviours: the Role of Inflammation.
Dual inhibition of EGFR and IL-6-STAT3 signalling by miR-146b: a potential targeted therapy for epithelial ovarian cancer.
Inhibitor of apoptosis-stimulating p53 protein protects against inflammatory bowel disease in mice models by inhibiting the nuclear factor kappa B signaling.
STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects psoriasis pathogenesis via regulating human keratinocyte proliferation.
Follicle-stimulating hormone worsens osteoarthritis by causing inflammation and chondrocyte dedifferentiation.
Platelet membrane-camouflaged silver metal-organic framework drug system against infections caused by methicillin-resistant Staphylococcus aureus.
Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.
Silencing lncRNA TUG1 Alleviates LPS-Induced Mouse Hepatocyte Inflammation by Targeting miR-140/TNF.
Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation.
Role of Endoplasmic Reticulum Stress in Otitis Media.
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Tacrolimus ameliorates tubulointerstitial inflammation in diabetic nephropathy via inhibiting the NFATc1/TRPC6 pathway.
Non-neuronal crosstalk promotes an inflammatory response in nodose ganglia cultures after exposure to byproducts from gram positive, high-fat-diet-associated gut bacteria.
The USP14-NLRC5 pathway inhibits titanium particle-induced osteolysis in mice by suppressing NF-κB and PI3K/AKT activities.
Ophiocordyceps lanpingensis polysaccharides attenuate pulmonary fibrosis in mice.
Wu-Mei-Wan prevents high-fat diet-induced obesity by reducing white adipose tissue and enhancing brown adipose tissue function.
Major depression accompanied with inflammation and multiple cytokines alterations: Evidences from clinical patients to macaca fascicularis and LPS-induced depressive mice model.
A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos.
Silencing of lncRNA MIAT alleviates LPS-induced pneumonia via regulating miR-147a/NKAP/NF-κB axis.
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro.
Apigenin Inhibits IL-6 Transcription and Suppresses Esophageal Carcinogenesis.
Inhibition of the mitochondrial complex-1 protects against carbon tetrachloride-induced acute liver injury.
Repair Effects of Astragalus Polysaccharides with Different Molecular Weights on Oxidatively Damaged HK-2 Cells.
Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells.
Clinicopathological significance of overexpression of interleukin-6 in colorectal cancer.
Upregulated Expression of microRNA-16 Correlates with Th17/Treg Cell Imbalance in Patients with Rheumatoid Arthritis.
Gong H, Wang T, Sun X, Zhang Y, Qiu Y, Sun W, Zhang Y, Teng P, Hu Y, Hu X, Ma L, Xu Q, Zhao H
Theranostics 2024;14(5):1886-1908
Theranostics 2024;14(5):1886-1908
Mediation of FOXA2/IL-6/IL-6R/STAT3 signaling pathway mediates benzo[a]pyrene-induced airway epithelial mesenchymal transformation in asthma.
Tang L, Chen B, Wang B, Xu J, Yan H, Shan Y, Zhao X
Environmental pollution (Barking, Essex : 1987) 2024 Sep 15;357:124384
Environmental pollution (Barking, Essex : 1987) 2024 Sep 15;357:124384
Exploring the efficacy and mechanism of Bailing capsule to improve polycystic ovary syndrome in mice based on intestinal-derived LPS-TLR4 pathway.
Guan HR, Li B, Zhang ZH, Wu HS, Wang N, Chen XF, Zhou CL, Bian XR, Li L, Xu WF, He XL, Dong YJ, Jiang NH, Su J, Lv GY, Chen SH
Journal of ethnopharmacology 2024 Sep 15;331:118274
Journal of ethnopharmacology 2024 Sep 15;331:118274
The association between endothelial function and autoimmune thyroiditis induced by iodine excess.
Wang D, Li P, Zhou Z, Jin M, Li B, Li F, Shen H
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2024 May;83:127413
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2024 May;83:127413
Mechanic study based on untargeted metabolomics of Pi-pa-run-fei-tang on pepper combined with ammonia induced chronic cough model mice.
Jie XL, Tong ZR, Xu XY, Wu JH, Jiang XL, Tao Y, Feng PS, Yu J, Lan JP, Wang P
Journal of ethnopharmacology 2024 May 23;326:117905
Journal of ethnopharmacology 2024 May 23;326:117905
Adipocyte-released adipomes in Chagas cardiomyopathy: Impact on cardiac metabolic and immune regulation.
Thangavel H, Dhanyalayam D, Kim M, Lizardo K, Sidrat T, Lopez JG, Wang X, Bansal S, Nagajyothi JF
iScience 2024 May 17;27(5):109672
iScience 2024 May 17;27(5):109672
The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice.
Li B, Zhang Y, Zheng Y, Cai H
iScience 2024 Mar 15;27(3):109134
iScience 2024 Mar 15;27(3):109134
ZeXieYin formula alleviates atherosclerosis by inhibiting the MAPK/NF-κB signaling pathway in APOE-/- mice to attenuate vascular inflammation and increase plaque stability.
Huang R, Sun Y, Liu R, Zhu B, Zhang H, Wu H
Journal of ethnopharmacology 2024 Jun 12;327:117969
Journal of ethnopharmacology 2024 Jun 12;327:117969
A bioenergetically-active ploy (glycerol sebacate)-based multiblock hydrogel improved diabetic wound healing through revitalizing mitochondrial metabolism.
Qi X, Liu C, Si J, Yin B, Huang J, Wang X, Huang J, Sun H, Zhu C, Zhang W
Cell proliferation 2024 Jul;57(7):e13613
Cell proliferation 2024 Jul;57(7):e13613
Macrophage ATG16L1 expression suppresses metabolic dysfunction-associated steatohepatitis progression by promoting lipophagy.
Wang Q, Bu Q, Xu Z, Liang Y, Zhou J, Pan Y, Zhou H, Lu L
Clinical and molecular hepatology 2024 Jul;30(3):515-538
Clinical and molecular hepatology 2024 Jul;30(3):515-538
Artificial aging conditions for Artemisia argyi leaves based on quality-inflammation-quality marker transformation.
Guo X, Wang D, Xiao Y, Cao H, Yao D, Chen G, Li S, Wang G, Tu J, Liu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155574
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155574
CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis.
Wen X, Fang G, Li H, Jiang Z, Du X, Liao Z, Liu R, Huang G, Meng F, Liao W, Zhang Z
International journal of biological macromolecules 2024 Jan;256(Pt 2):128453
International journal of biological macromolecules 2024 Jan;256(Pt 2):128453
FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-κB signaling pathway.
Lang Y, Wang Q, Sheng Q, Lu S, Yang M, Kong Z, Gao Y, Fan X, Shen N, Wang R, Lv Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23409
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23409
The SGLT2 inhibitor empagliflozin attenuates atherosclerosis progression by inducing autophagy.
Xu H, Fu J, Tu Q, Shuai Q, Chen Y, Wu F, Cao Z
Journal of physiology and biochemistry 2024 Feb;80(1):27-39
Journal of physiology and biochemistry 2024 Feb;80(1):27-39
Wound microenvironment-responsive dually cross-linked nanofibrillar peptide hydrogels for efficient hemostatic control and multi-faceted wound management.
Zheng Y, Sun L, Zhai Z, Cao F, Zhang T, Jiao Q, Xu K, Zhong W
International journal of biological macromolecules 2024 Feb;259(Pt 1):129133
International journal of biological macromolecules 2024 Feb;259(Pt 1):129133
Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages.
Ghosh R, Bishayi B
Microbial pathogenesis 2024 Feb;187:106518
Microbial pathogenesis 2024 Feb;187:106518
Calcitonin gene-related peptide attenuated discogenic low back pain in rats possibly via inhibiting microglia activation.
Xie W, Li F, Han Y, Chi X, Qin Y, Ye F, Li Z, Xiao J
Heliyon 2024 Feb 15;10(3):e25906
Heliyon 2024 Feb 15;10(3):e25906
Microbiome analysis reveals the inducing effect of Pseudomonas on prostatic hyperplasia via activating NF-κB signalling.
Li J, Li Y, Zhou L, Li H, Wan T, Tang J, Zhou L, Xie H, Wang L
Virulence 2024 Dec;15(1):2313410
Virulence 2024 Dec;15(1):2313410
Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome.
Tanaka T, Urata Y, Harada M, Kunitomi C, Kusamoto A, Koike H, Xu Z, Sakaguchi N, Tsuchida C, Komura A, Teshima A, Takahashi N, Wada-Hiraike O, Hirota Y, Osuga Y
Molecular human reproduction 2024 Apr 30;30(5)
Molecular human reproduction 2024 Apr 30;30(5)
Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury.
Hao Z, Zhang Z, Zhao Y, Wang D
The American journal of Chinese medicine 2023;51(2):355-372
The American journal of Chinese medicine 2023;51(2):355-372
C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways.
Chen Y, Liu Y, Li H, Huna R, Tan X, Li N, Zhang Y, Jiao X, Liu M
Journal of applied oral science : revista FOB 2023;31:e20220404
Journal of applied oral science : revista FOB 2023;31:e20220404
Topical Delivery of ROS-Responsive Methotrexate Prodrug Nanoassemblies by a Dissolvable Microneedle Patch for Psoriasis Therapy.
Zhou Y, Yang L, Lyu Y, Wu D, Zhu Y, Li J, Jiang D, Xin X, Yin L
International journal of nanomedicine 2023;18:899-915
International journal of nanomedicine 2023;18:899-915
Zhoushi Qiling decoction inhibits proliferation of human prostate cancer cells through IL6/STAT3 pathway.
Cao H, Feng Y, Sun P, Chen L, Wang D, Gao R
Journal of Cancer 2023;14(12):2246-2254
Journal of Cancer 2023;14(12):2246-2254
Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD(+)/SIRT1 axis.
Wu K, Li B, Ma Y, Tu T, Lin Q, Zhu J, Zhou Y, Liu N, Liu Q
Frontiers in endocrinology 2023;14:1099134
Frontiers in endocrinology 2023;14:1099134
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8.
Hu Y, Wang S, Wu L, Yang K, Yang F, Yang J, Hu S, Yao Y, Xia X, Liu Y, Peng L, Wan J, Shen C, Xu T
Chinese journal of natural medicines 2023 Sep;21(9):670-681
Chinese journal of natural medicines 2023 Sep;21(9):670-681
Neurovascular protection of alisol A on cerebral ischemia mice through activating the AKT/GSK3β pathway.
Li H, Zhang C, Zhou Y, Deng Y, Zheng X, Xue X
Aging 2023 Oct 26;15(20):11639-11653
Aging 2023 Oct 26;15(20):11639-11653
Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice.
Yang L, Lu P, Qi X, Yang Q, Liu L, Dou T, Guan Q, Yu C
iScience 2023 Oct 20;26(10):108082
iScience 2023 Oct 20;26(10):108082
Exploring the therapeutic potential of a nano micelle containing a carbon monoxide-releasing molecule for metabolic-associated fatty liver disease by modulating hypoxia-inducible factor-1α.
Cui Y, Guo C, Xia Z, Xue Y, Song B, Hu W, He X, Liang S, Wei Y, Zhang C, Wang H, Xu D, Zhang S, Fang J
Acta biomaterialia 2023 Oct 1;169:500-516
Acta biomaterialia 2023 Oct 1;169:500-516
Angiogenesis, hemocompatibility and bactericidal effect of bioactive natural polymer-based bilayer adhesive skin substitute for infected burned wound healing.
Shahriari-Khalaji M, Sattar M, Cao R, Zhu M
Bioactive materials 2023 Nov;29:177-195
Bioactive materials 2023 Nov;29:177-195
Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.
Miao X, Ye H, Cui X, Guo X, Su F
Nutrition research (New York, N.Y.) 2023 Nov;119:119-131
Nutrition research (New York, N.Y.) 2023 Nov;119:119-131
FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.
Tian T, Xie X, Yi W, Zhou Y, Xu Y, Wang Z, Zhang J, Lin M, Zhang R, Lv Z, Li X, Lv L, Xu Y
Cell reports 2023 Nov 28;42(11):113362
Cell reports 2023 Nov 28;42(11):113362
Jiawei Yanghe Decoction suppresses breast cancer by regulating immune responses via JAK2/STAT3 signaling pathway.
You Y, Chen X, Chen X, Li H, Zhou R, Zhou J, Chen M, Peng B, Ji S, Kwan HY, Zou L, Yu J, Liu Y, Wu Y, Zhao X
Journal of ethnopharmacology 2023 Nov 15;316:116358
Journal of ethnopharmacology 2023 Nov 15;316:116358
Histone methyltransferase KMT2D promotes prostate cancer progression through paracrine IL-6 signaling.
Zhang J, Ye Y, Xu Z, Luo M, Wu C, Zhang Y, Lv S, Wei Q
Biochemical and biophysical research communications 2023 May 7;655:35-43
Biochemical and biophysical research communications 2023 May 7;655:35-43
Determination of the optimal concentration and duration of C5aR antagonist application in an inflammatory model of human dental pulp cells.
Hu J, Tan X, Wei X, Hu W, Gao L, Cao X, Yang H, Jiang Z, Li N, Teng L, Liu M
FEBS open bio 2023 Mar;13(3):570-581
FEBS open bio 2023 Mar;13(3):570-581
Protective effect of HDACIs in improves survival and organ injury after CLP-induced sepsis.
Niu K, Qu S, Yang L, Zhang H, Yuan J, Fan H, Li X, Tao K
Surgery open science 2023 Mar;12:35-42
Surgery open science 2023 Mar;12:35-42
Apigenin Inhibits the Progression of Osteoarthritis by Mediating Macrophage Polarization.
Ji X, Du W, Che W, Wang L, Zhao L
Molecules (Basel, Switzerland) 2023 Mar 24;28(7)
Molecules (Basel, Switzerland) 2023 Mar 24;28(7)
Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice.
Peng S, Yu Y, Li J, Jiang D, Xu G, Wu L, Hu J
Aging 2023 Mar 17;15(6):1977-2004
Aging 2023 Mar 17;15(6):1977-2004
Increased Cellular Expression of Interleukin-6 in Patients With Ossification of the Posterior Longitudinal Ligament.
Saito H, Yayama T, Mori K, Kumagai K, Fujikawa H, Chosei Y, Imai S
Spine 2023 Mar 15;48(6):E78-E86
Spine 2023 Mar 15;48(6):E78-E86
Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis.
Yan S, Dong W, Li Z, Wei J, Han T, Wang J, Lin F
Journal of orthopaedic surgery and research 2023 Mar 13;18(1):198
Journal of orthopaedic surgery and research 2023 Mar 13;18(1):198
Simultaneous neutralization of TGF-β and IL-6 attenuates Staphylococcus aureus-induced arthritic inflammation through differential modulation of splenic and synovial macrophages.
Ghosh R, Dey R, Sawoo R, Bishayi B
Scandinavian journal of immunology 2023 Jun;97(6):e13252
Scandinavian journal of immunology 2023 Jun;97(6):e13252
Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis.
Yang X, Ou Y, Yang Y, Wang L, Zhang Y, Zhao F, Shui P, Qing J
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(14):1242-1253
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(14):1242-1253
Gegen-Qinlian decoction alleviates anxiety-like behaviors in methamphetamine-withdrawn mice by regulating Akkermansia and metabolism in the colon.
Lu X, Fan Y, Peng Y, Pan W, Du D, Xu X, Li N, He T, Nie J, Shi P, Ge F, Liu D, Chen Y, Guan X
Chinese medicine 2023 Jul 16;18(1):85
Chinese medicine 2023 Jul 16;18(1):85
A COMPARATIVE ANALYSIS TO DETERMINE THE OPTIMUM HISTONE DEACETYLASE INHIBITORS AND ADMINISTRATION ROUTE FOR IMPROVING SURVIVAL AND ORGAN INJURY IN RATS AFTER HEMORRHAGIC SHOCK.
Niu K, Yang L, Song W, Liu Z, Yuan J, Zhang H, Zhang W, Wang J, Tao K
Shock (Augusta, Ga.) 2023 Jul 1;60(1):75-83
Shock (Augusta, Ga.) 2023 Jul 1;60(1):75-83
Inflammatory mechanisms of Ginkgo Biloba extract in improving memory functions through lncRNA-COX2/NF-κB pathway in mice with status epilepticus.
Zou X, Liu S, Zou H, Zhou W, Fu H, Wei J, Zhang J, Zeng H, Tan T, Zhou W, Wu H, Chen X, Zhou X
CNS neuroscience & therapeutics 2023 Jan;29(1):471-482
CNS neuroscience & therapeutics 2023 Jan;29(1):471-482
Treat the "Untreatable" by a Photothermal Agent: Triggering Heat and Immunological Responses for Rabies Virus Inactivation.
Bai Y, Huang P, Feng N, Li Y, Huang J, Jin H, Zhang M, Sun J, Li N, Zhang H, Xia X, Tang BZ, Wang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(2):e2205461
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(2):e2205461
Susceptibility of Fat Tissue to SARS-CoV-2 Infection in Female hACE2 Mouse Model.
Thangavel H, Dhanyalayam D, Lizardo K, Oswal N, Dolgov E, Perlin DS, Nagajyothi JF
International journal of molecular sciences 2023 Jan 9;24(2)
International journal of molecular sciences 2023 Jan 9;24(2)
Single-cell profiling reveals mechanisms of uncontrolled inflammation and glycolysis in decidual stromal cell subtypes in recurrent miscarriage.
Bao S, Chen Z, Qin D, Xu H, Deng X, Zhang R, Ma J, Lu Z, Jiang S, Zhang X
Human reproduction (Oxford, England) 2023 Jan 5;38(1):57-74
Human reproduction (Oxford, England) 2023 Jan 5;38(1):57-74
Diets Differently Regulate Tumorigenesis in Young E0771 Syngeneic Breast Cancer Mouse Model.
Thangavel H, Lizardo K, Dhanyalayam D, De Assis S, Nagajyothi JF
Journal of clinical medicine 2023 Jan 4;12(2)
Journal of clinical medicine 2023 Jan 4;12(2)
Metformin Directly Binds to MMP-9 to Improve Plaque Stability.
Chen X, Wang S, Xu W, Zhao M, Zhang Y, Xiao H
Journal of cardiovascular development and disease 2023 Jan 30;10(2)
Journal of cardiovascular development and disease 2023 Jan 30;10(2)
Diets Differently Regulate Pulmonary Pathogenesis and Immune Signaling in Mice during Acute and Chronic Mycobacterium tuberculosis Infection.
Oswal N, Thangavel H, Lizardo K, Dhanyalayam D, Sidrat T, Salgame P, Nagajyothi JF
Life (Basel, Switzerland) 2023 Jan 13;13(1)
Life (Basel, Switzerland) 2023 Jan 13;13(1)
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Yang J, Han F, Wu G, Dong Y, Su H, Xu J, Li J
Digestive diseases and sciences 2023 Feb;68(2):478-486
Digestive diseases and sciences 2023 Feb;68(2):478-486
Crocetin confers neuroprotection and is anti-inflammatory in rats with induced glaucoma.
Li Q, Feng P, Lin S, Xu Z, Zhao J, Chen Z, Luo Z, Tao Y, Chen S, Wang P
Molecular biology reports 2023 Feb;50(2):1321-1331
Molecular biology reports 2023 Feb;50(2):1321-1331
Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization.
Li Y, Zhang J, Wang C, Jiang Z, Lai K, Wang Y, Yang G
Acta biomaterialia 2023 Feb;157:108-123
Acta biomaterialia 2023 Feb;157:108-123
Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway.
Pang Y, Zhao L, Ji X, Guo K, Yin X
Molecules (Basel, Switzerland) 2023 Feb 7;28(4)
Molecules (Basel, Switzerland) 2023 Feb 7;28(4)
Tunicamycin induces depression-like behaviors in male rats, accompanied by initiated chaperon-mediated autophagy and decreased synaptic protein expression in the hippocampus.
Yuan G, Xiao L, Xie Y, Si L, Xu H, Xu W, Wang G
Neuroscience letters 2023 Feb 28;798:137058
Neuroscience letters 2023 Feb 28;798:137058
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma.
Jie XL, Luo ZR, Yu J, Tong ZR, Li QQ, Wu JH, Tao Y, Feng PS, Lan JP, Wang P
Journal of ethnopharmacology 2023 Dec 5;317:116719
Journal of ethnopharmacology 2023 Dec 5;317:116719
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization.
Shen T, Lin R, Hu C, Yu D, Ren C, Li T, Zhu M, Wan Z, Su T, Wu Y, Cai W, Yu J
Journal of neuroinflammation 2023 Dec 21;20(1):308
Journal of neuroinflammation 2023 Dec 21;20(1):308
Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease.
Fan C, Ling-Hu A, Sun D, Gao W, Zhang C, Duan X, Li H, Tian W, Yu Q, Ke Z
Journal of agricultural and food chemistry 2023 Dec 20;71(50):20105-20117
Journal of agricultural and food chemistry 2023 Dec 20;71(50):20105-20117
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
Bai J, Qian B, Cai T, Chen Y, Li T, Cheng Y, Wu Z, Liu C, Ye M, Du Y, Fu W
Journal of agricultural and food chemistry 2023 Dec 13;71(49):19475-19487
Journal of agricultural and food chemistry 2023 Dec 13;71(49):19475-19487
PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation.
Mo J, Lu Z, Peng J, Li XP, Lan L, Wang H, Peng Y
Journal of psychiatric research 2023 Aug;164:150-161
Journal of psychiatric research 2023 Aug;164:150-161
Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition.
Ma H, Zhang X, Liu L, Huang Y, Sun S, Chen K, Xin Q, Liu P, Yan Y, Wang Y, Li Y, Liu H, Zhao R, Tan K, Chen X, Yuan X, Li Y, Liu Y, Dai H, Liu C, Wang H, Zhang XD
Science advances 2023 Aug 2;9(31):eadh7828
Science advances 2023 Aug 2;9(31):eadh7828
Development of a method to identify persistent and blanchable redness by skin blotting in mice.
Nakai A, Minematsu T, Nitta S, Hsu WJ, Tobe H, Sanada H
International wound journal 2023 Apr;20(4):1168-1182
International wound journal 2023 Apr;20(4):1168-1182
A stress-induced cilium-to-PML-NB route drives senescence initiation.
Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, Chen C, Hao J, Zhao D, LeBrasseur NK, Kirkland JL, Chini EN, Wei Q, Ling K, Hu J
Nature communications 2023 Apr 3;14(1):1840
Nature communications 2023 Apr 3;14(1):1840
Patchouli alcohol ameliorates depression-like behaviors through inhibiting NLRP3-mediated neuroinflammation in male stress-exposed mice.
He H, Xie X, Zhang J, Mo L, Kang X, Zhang Y, Wang L, Hu N, Xie L, Peng C, You Z
Journal of affective disorders 2023 Apr 1;326:120-131
Journal of affective disorders 2023 Apr 1;326:120-131
Sex Differences in Cardiac Pathology of SARS-CoV2 Infected and Trypanosoma cruzi Co-infected Mice.
Dhanyalayam D, Thangavel H, Lizardo K, Oswal N, Dolgov E, Perlin DS, Nagajyothi JF
Frontiers in cardiovascular medicine 2022;9:783974
Frontiers in cardiovascular medicine 2022;9:783974
Dietary camellia seed oil attenuates liver injury in mice chronically exposed to alcohol.
Guo R, Zhu J, Chen L, Li J, Ding Q, Han Q, Zheng W, Li S
Frontiers in nutrition 2022;9:1026740
Frontiers in nutrition 2022;9:1026740
Atractylodes lancea Rhizoma Attenuates DSS-Induced Colitis by Regulating Intestinal Flora and Metabolites.
Qu L, Liu C, Ke C, Zhan X, Li L, Xu H, Xu K, Liu Y
The American journal of Chinese medicine 2022;50(2):525-552
The American journal of Chinese medicine 2022;50(2):525-552
Long Noncoding RNA ENSG00000254693 Promotes Diabetic Kidney Disease via Interacting with HuR.
Yu Q, Lin J, Ma Q, Li Y, Wang Q, Chen H, Liu Y, Liu B
Journal of diabetes research 2022;2022:8679548
Journal of diabetes research 2022;2022:8679548
ETC-1002 Attenuates Porphyromonas gingivalis Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells via the AMPK/NF-κB Pathway and Exerts Ameliorative Effects in Experimental Periodontitis in Mice.
Li H, Zhang P, Lin H, Gao H, Yin J
Disease markers 2022;2022:8583674
Disease markers 2022;2022:8583674
BNTA alleviates inflammatory osteolysis by the SOD mediated anti-oxidation and anti-inflammation effect on inhibiting osteoclastogenesis.
Wang H, Cao X, Guo J, Yang X, Sun X, Fu Z, Qin A, Wu Y, Zhao J
Frontiers in pharmacology 2022;13:939929
Frontiers in pharmacology 2022;13:939929
Neddylation Inhibition Causes Impaired Mouse Embryo Quality and Blastocyst Hatching Failure Through Elevated Oxidative Stress and Reduced IL-1β.
Yang G, Chen J, He Y, Luo H, Yuan H, Chen L, Huang L, Mao F, Hu S, Qian Y, Miao C, Feng R
Frontiers in immunology 2022;13:925702
Frontiers in immunology 2022;13:925702
Neutrophil Extracellular Traps Regulate HMGB1 Translocation and Kupffer Cell M1 Polarization During Acute Liver Transplantation Rejection.
Liu Y, Pu X, Qin X, Gong J, Huang Z, Luo Y, Mou T, Zhou B, Shen A, Wu Z
Frontiers in immunology 2022;13:823511
Frontiers in immunology 2022;13:823511
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.
Wang J, Yang X, Zeng W, Zhang X, Yang X, Xu Y, Liu K, Zhang Z, Xu Y, Cao X
Journal of Parkinson's disease 2022;12(7):2097-2116
Journal of Parkinson's disease 2022;12(7):2097-2116
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Wang FF, Zhao PY, He XJ, Jiang K, Wang TS, Xiao JW, Sun DB, Guo DH
Frontiers in cellular and infection microbiology 2022;12:827750
Frontiers in cellular and infection microbiology 2022;12:827750
FumDSB can alleviate the inflammatory response induced by fumonisin B(1) in growing pigs.
Liu Q, Huang L, Cui Z, Qiao B, Li F, Wang C
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 2022 Sep;39(9):1619-1633
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 2022 Sep;39(9):1619-1633
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
Luo L, Gong J, Wang Z, Liu Y, Cao J, Qin J, Zuo R, Zhang H, Wang S, Zhao P, Yang D, Zhang M, Wang Y, Zhang J, Zhou Y, Li C, Ni B, Tian Z, Liu M
Bioactive materials 2022 Sep;15:29-43
Bioactive materials 2022 Sep;15:29-43
P2Y(14) receptor in trigeminal ganglion contributes to neuropathic pain in mice.
Lin J, Fang X, Liu F, Zhang Y, Li Y, Fang Z, Tang Q, Li C, Zhou C, Shen J
European journal of pharmacology 2022 Sep 15;931:175211
European journal of pharmacology 2022 Sep 15;931:175211
Cold exposure-induced endoplasmic reticulum stress regulates autophagy through the SIRT2/FoxO1 signaling pathway.
Guo J, Nie J, Chen Z, Wang X, Hu H, Xu J, Lu J, Ma L, Ji H, Yuan J, Xu B
Journal of cellular physiology 2022 Oct;237(10):3960-3970
Journal of cellular physiology 2022 Oct;237(10):3960-3970
Schisandrol B protects against cholestatic liver injury by inhibiting pyroptosis through pregnane X receptor.
Liang H, Yang X, Li H, Wang X, Su H, Li X, Tian J, Cai C, Huang M, Bi H
Biochemical pharmacology 2022 Oct;204:115222
Biochemical pharmacology 2022 Oct;204:115222
miR-126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis-associated colorectal cancer.
Wu S, Yuan W, Luo W, Nie K, Wu X, Meng X, Shen Z, Wang X
Molecular oncology 2022 Oct;16(19):3465-3489
Molecular oncology 2022 Oct;16(19):3465-3489
Honokiol alleviates ulcerative colitis by targeting PPAR-γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro.
Wang N, Kong R, Han W, Bao W, Shi Y, Ye L, Lu J
International immunopharmacology 2022 Oct;111:109058
International immunopharmacology 2022 Oct;111:109058
Transcriptomic Analysis Reveals Lactobacillus reuteri Alleviating Alcohol-Induced Liver Injury in Mice by Enhancing the Farnesoid X Receptor Signaling Pathway.
Cheng Y, Xiang X, Liu C, Cai T, Li T, Chen Y, Bai J, Shi H, Zheng T, Huang M, Fu W
Journal of agricultural and food chemistry 2022 Oct 5;70(39):12550-12564
Journal of agricultural and food chemistry 2022 Oct 5;70(39):12550-12564
Multipronged Micelles-Hydrogel for Targeted and Prolonged Drug Delivery in Chronic Wound Infections.
Zhao Q, Liu J, Liu S, Han J, Chen Y, Shen J, Zhu K, Ma X
ACS applied materials & interfaces 2022 Oct 19;14(41):46224-46238
ACS applied materials & interfaces 2022 Oct 19;14(41):46224-46238
Toll-like receptor 4 deficiency alleviates lipopolysaccharide-induced intestinal barrier dysfunction.
Zhan L, Zheng J, Meng J, Fu D, Pang L, Ji C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113778
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113778
Blockade of Kv1.3 Potassium Channel Inhibits Microglia-Mediated Neuroinflammation in Epilepsy.
Zhang X, Liang P, Zhang Y, Wu Y, Song Y, Wang X, Chen T, Peng B, Liu W, Yin J, Han S, He X
International journal of molecular sciences 2022 Nov 24;23(23)
International journal of molecular sciences 2022 Nov 24;23(23)
Empagliflozin inhibits macrophage inflammation through AMPK signaling pathway and plays an anti-atherosclerosis role.
Fu J, Xu H, Wu F, Tu Q, Dong X, Xie H, Cao Z
International journal of cardiology 2022 Nov 15;367:56-62
International journal of cardiology 2022 Nov 15;367:56-62
Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway.
Zhou P, Lai J, Li Y, Deng J, Zhao C, Huang Q, Yang F, Yang S, Wu Y, Tang X, Huang F, Wang L, Huang X, Zou W, Wu J
International journal of molecular sciences 2022 Nov 14;23(22)
International journal of molecular sciences 2022 Nov 14;23(22)
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages.
Chen L, Li Y, Zeng S, Duan S, Huang Z, Liang Y
In vitro cellular & developmental biology. Animal 2022 May;58(5):408-418
In vitro cellular & developmental biology. Animal 2022 May;58(5):408-418
LncRNA SOX2OT facilitates LPS-induced inflammatory injury by regulating intercellular adhesion molecule 1 (ICAM1) via sponging miR-215-5p.
Zhu W, Peng F, Cui X, Li J, Sun C
Clinical immunology (Orlando, Fla.) 2022 May;238:109006
Clinical immunology (Orlando, Fla.) 2022 May;238:109006
Nanoformulation of a carbon monoxide releasing molecule protects against cyclosporin A-induced nephrotoxicity and renal fibrosis via the suppression of the NLRP3 inflammasome mediated TGF-β/Smad pathway.
Xia Z, Zhang C, Guo C, Song B, Hu W, Cui Y, Xue Y, Xia M, Xu D, Zhang S, Fang J
Acta biomaterialia 2022 May;144:42-53
Acta biomaterialia 2022 May;144:42-53
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
Li T, Chen Y, Tan P, Shi H, Huang Z, Cai T, Cheng Y, Du Y, Fu W
Bioorganic chemistry 2022 May;122:105737
Bioorganic chemistry 2022 May;122:105737
Association between Incidental Pelvic Inflammation and Aggressive Prostate Cancer.
Chakravarty D, Ratnani P, Huang L, Dovey Z, Sobotka S, Berryhill R, Merisaari H, Al Shaarani M, Rai R, Jambor I, Yadav KK, Mittan S, Parekh S, Kodysh J, Wagaskar V, Brody R, Cordon-Cardo C, Rykunov D, Reva B, Davicioni E, Wiklund P, Bhardwaj N, Nair SS, Tewari AK
Cancers 2022 May 31;14(11)
Cancers 2022 May 31;14(11)
Curcumin Derivative C66 Suppresses Pancreatic Cancer Progression through the Inhibition of JNK-Mediated Inflammation.
Chen H, Jiang Y, Liu R, Deng J, Chen Q, Chen L, Liang G, Chen X, Xu Z
Molecules (Basel, Switzerland) 2022 May 11;27(10)
Molecules (Basel, Switzerland) 2022 May 11;27(10)
Interleukin-4 activates the PI3K/AKT signaling to promote apoptosis and inhibit the proliferation of granulosa cells.
Han Y, Yao R, Yang Z, Li S, Meng W, Zhang Y, Zhang Y, Luo H
Experimental cell research 2022 Mar 1;412(1):113002
Experimental cell research 2022 Mar 1;412(1):113002
Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Zhao J, Chen S, Yang C, Zhou M, Yang T, Sun B, Zhu J, Zhang H, Lu Q, Li L, Yang Z, Song B, Shen W, Yi S, Dai S
Biochemical pharmacology 2022 Jun;200:115047
Biochemical pharmacology 2022 Jun;200:115047
MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell pyroptosis, and inflammatory bowel disease in mice.
Wu G, Zhang D, Yang L, Wu Q, Yuan L
Molecular immunology 2022 Jun;146:57-68
Molecular immunology 2022 Jun;146:57-68
Insulin-incubated palladium clusters promote recovery after brain injury.
Fu S, Zhao S, Chen H, Yang W, Xia X, Xu X, Liang Z, Feng X, Wang Z, Ai P, Ding L, Cai Q, Wang Y, Zhang Y, Zhu J, Zhang B, Zheng JC
Journal of nanobiotechnology 2022 Jun 25;20(1):299
Journal of nanobiotechnology 2022 Jun 25;20(1):299
Flavokawain B alleviates LPS-induced acute lung injury via targeting myeloid differentiation factor 2.
Luo W, Yang LB, Qian CC, Ma B, Manjengwa GM, Miao XM, Wang J, Hu CH, Jin B, Zhang LX, Zheng C, Liang G, Wang Y
Acta pharmacologica Sinica 2022 Jul;43(7):1758-1768
Acta pharmacologica Sinica 2022 Jul;43(7):1758-1768
Construction and comprehensive analysis of a lncRNA-mRNA interactive network to reveal a potential lncRNA for hepatic encephalopathy development.
Zhang C, Ni W, Zhu Y, Lin J, Li H, Zhao Z, Wang K, Huo H, Luo M
Human cell 2022 Jul;35(4):1060-1070
Human cell 2022 Jul;35(4):1060-1070
IL-17A drives cognitive aging probably via inducing neuroinflammation and theta oscillation disruption in the hippocampus.
Li Y, Mao M, Zhu L, Sun Q, Tong J, Zhou Z
International immunopharmacology 2022 Jul;108:108898
International immunopharmacology 2022 Jul;108:108898
Synthesis and biological evaluation of novel schisanhenol derivatives as potential hepatoprotective agents.
Deng L, Cheng S, Li J, Xu X, Hao X, Fan Y, Mu S
European journal of medicinal chemistry 2022 Jan 5;227:113919
European journal of medicinal chemistry 2022 Jan 5;227:113919
Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection.
Xu B, Yang R, Yang B, Li L, Chen J, Fu J, Qu X, Huo D, Tan C, Chen H, Peng Z, Wang X
Molecular brain 2022 Jan 3;15(1):4
Molecular brain 2022 Jan 3;15(1):4
tRNA-derived fragment TRF365 regulates the metabolism of anterior cruciate ligament cells by targeting IKBKB.
Long D, Xu Y, Mao G, Xin R, Deng Z, Liao H, Li Z, Yang Z, Yu B, Yang Z, He A, Zhang Z, Kang Y
Cell death discovery 2022 Jan 10;8(1):19
Cell death discovery 2022 Jan 10;8(1):19
Sodium butyrate alleviates pre-eclampsia in pregnant rats by improving the gut microbiota and short-chain fatty acid metabolites production.
Yong W, Zhao Y, Jiang X, Li P
Journal of applied microbiology 2022 Feb;132(2):1370-1383
Journal of applied microbiology 2022 Feb;132(2):1370-1383
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Meng Q, Li B, Huang N, Wei S, Ren Q, Wu S, Li X, Chen R
Journal of hazardous materials 2022 Feb 15;424(Pt B):127354
Journal of hazardous materials 2022 Feb 15;424(Pt B):127354
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Ni L, Xiao J, Zhang D, Shao Z, Huang C, Wang S, Wu Y, Tian N, Sun L, Wu A, Zhou Y, Wang X, Zhang X
Cell death & disease 2022 Feb 10;13(2):140
Cell death & disease 2022 Feb 10;13(2):140
Cytokine Profile From the Ligamentum Flavum in Patients with Ossification of the Posterior Longitudinal Ligament in the Cervical Spine.
Yayama T, Mori K, Saito H, Fujikawa H, Kitagawa M, Okumura N, Nishizawa K, Nakamura A, Kumagai K, Mimura T, Imai S
Spine 2022 Feb 1;47(3):277-285
Spine 2022 Feb 1;47(3):277-285
The miR-26a-5p/IL-6 axis alleviates sepsis-induced acute kidney injury by inhibiting renal inflammation.
Chen Y, Zhou X, Wu Y
Renal failure 2022 Dec;44(1):551-561
Renal failure 2022 Dec;44(1):551-561
Yanghe decoction attenuated pain hypersensitivity induced by michigan cancer foundation-7 injection in rats with bone metastases from breast cancer by inhibiting transient receptor potential ankyrin 1.
Hui G, Yang LI, Lei F, Yujie X, Lizhong H, Dan M, Hui Z
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Dec;42(6):948-955
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Dec;42(6):948-955
A Multicenter, Single-Blind, Case-Control, Immunohistochemical Study of Orbital Tissue in Thyroid Eye Disease.
Hai YP, Saeed MEM, Ponto KA, Elflein HM, Lee ACH, Fang S, Zhou H, Frommer L, Längericht J, Efferth T, Kahaly GJ
Thyroid : official journal of the American Thyroid Association 2022 Dec;32(12):1547-1558
Thyroid : official journal of the American Thyroid Association 2022 Dec;32(12):1547-1558
Endogenous neutralization of TGF-β and IL-6 ameliorates septic arthritis by altering RANKL/OPG interaction in lymphocytes.
Ghosh R, Dey R, Sawoo R, Haque W, Bishayi B
Molecular immunology 2022 Dec;152:183-206
Molecular immunology 2022 Dec;152:183-206
PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6.
Zhong L, Tan W, Yang Q, Zou Z, Zhou R, Huang Y, Qiu Z, Zheng K, Huang Z
Journal of gastrointestinal oncology 2022 Dec;13(6):2989-3008
Journal of gastrointestinal oncology 2022 Dec;13(6):2989-3008
Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.
Li L, Xu W, Luo Y, Lao C, Tong X, Du J, Huang B, Li D, Chen J, Ye H, Cong F, Guo X, Li J
Carbohydrate polymers 2022 Dec 1;297:120032
Carbohydrate polymers 2022 Dec 1;297:120032
l-Arginine prevents 4-hydroxy-2-nonenal accumulation and depresses inflammation via inhibiting NF-κB activation.
Liang M, Wang Z, Li H, Liu B, Yang L
Journal of biochemical and molecular toxicology 2022 Aug;36(8):e23087
Journal of biochemical and molecular toxicology 2022 Aug;36(8):e23087
Adropin Carried by Reactive Oxygen Species-Responsive Nanocapsules Ameliorates Renal Lipid Toxicity in Diabetic Mice.
Yu M, Wang D, Zhong D, Xie W, Luo J
ACS applied materials & interfaces 2022 Aug 24;14(33):37330-37344
ACS applied materials & interfaces 2022 Aug 24;14(33):37330-37344
Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer's disease.
Dong Y, Yu H, Li X, Bian K, Zheng Y, Dai M, Feng X, Sun Y, He Y, Yu B, Zhang H, Wu J, Yu X, Wu H, Kong W
Journal of neuroinflammation 2022 Aug 15;19(1):205
Journal of neuroinflammation 2022 Aug 15;19(1):205
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Jia Y, Chen J, Zheng Z, Tao Y, Zhang S, Zou M, Yang Y, Xue M, Hu F, Li Y, Zhang Q, Xue Y, Zheng Z
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Atractylenolide-1 targets SPHK1 and B4GALT2 to regulate intestinal metabolism and flora composition to improve inflammation in mice with colitis.
Qu L, Shi K, Xu J, Liu C, Ke C, Zhan X, Xu K, Liu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153945
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153945
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Tetrastigma hemsleyanum Diels et Gilg ameliorates lipopolysaccharide induced sepsis via repairing the intestinal mucosal barrier.
Zhan L, Pu J, Zheng J, Hang S, Pang L, Dai M, Ji C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Apr;148:112741
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Apr;148:112741
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
Wu M, Cong Y, Wang K, Yu H, Zhang X, Ma M, Duan Z, Pei X
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
The Transcription Factor C/EBPβ Promotes HFL-1 Cell Migration, Proliferation, and Inflammation by Activating lncRNA HAS2-AS1 in Hypoxia.
Yang X, Qi F, Wei S, Lin L, Liu X
Frontiers in cell and developmental biology 2021;9:651913
Frontiers in cell and developmental biology 2021;9:651913
The mechanism and candidate compounds of aged citrus peel (chenpi) preventing chronic obstructive pulmonary disease and its progression to lung cancer.
Zhou L, Gu W, Kui F, Gao F, Niu Y, Li W, Zhang Y, Guo L, Wang J, Guo Z, Du G
Food & nutrition research 2021;65
Food & nutrition research 2021;65
PAK1 Silencing Attenuated Proinflammatory Macrophage Activation and Foam Cell Formation by Increasing PPARγ Expression.
Cheng WL, Zhang Q, Li B, Cao JL, Jiao L, Chao SP, Lu Z, Zhao F
Oxidative medicine and cellular longevity 2021;2021:6957900
Oxidative medicine and cellular longevity 2021;2021:6957900
TLR4-NLRP3-GSDMD-Mediated Pyroptosis Plays an Important Role in Aggravated Liver Injury of CD38(-/-) Sepsis Mice.
Zhang H, Du Y, Guo Y, Wang Z, Li H, Lv Z, Zeng L, Chen Y, Xie Z, Li R
Journal of immunology research 2021;2021:6687555
Journal of immunology research 2021;2021:6687555
Chlorogenic Acid Alleviates Colon Mucosal Damage Induced by a High-Fat Diet via Gut Microflora Adjustment to Increase Short-Chain Fatty Acid Accumulation in Rats.
Xie MG, Fei YQ, Wang Y, Wang WY, Wang Z
Oxidative medicine and cellular longevity 2021;2021:3456542
Oxidative medicine and cellular longevity 2021;2021:3456542
Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway.
Xin Y, Shang X, Sun X, Liu Y, Xu G, Xue G
Evidence-based complementary and alternative medicine : eCAM 2021;2021:2130229
Evidence-based complementary and alternative medicine : eCAM 2021;2021:2130229
Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways.
Wang J, Ge S, Wang Y, Liu Y, Qiu L, Li J, Huang X, Sun L
Drug design, development and therapy 2021;15:3697-3708
Drug design, development and therapy 2021;15:3697-3708
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.
Wang D, Song M, Shen LF, Han L, Zhu P, Jia X, Shang GK, Cao Y, Zhang W, Zhong M, Wang ZH
Frontiers in physiology 2021;12:786895
Frontiers in physiology 2021;12:786895
Atractylodin Attenuates Dextran Sulfate Sodium-Induced Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting Inflammatory Response Through the MAPK Pathway.
Qu L, Lin X, Liu C, Ke C, Zhou Z, Xu K, Cao G, Liu Y
Frontiers in pharmacology 2021;12:665376
Frontiers in pharmacology 2021;12:665376
SARS-CoV-2 Accessory Protein ORF7b Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Cells.
Yang R, Zhao Q, Rao J, Zeng F, Yuan S, Ji M, Sun X, Li J, Yang J, Cui J, Jin Z, Liu L, Liu Z
Frontiers in microbiology 2021;12:654709
Frontiers in microbiology 2021;12:654709
miR-23a-3p regulates the inflammatory response and fibrosis in diabetic kidney disease by targeting early growth response 1.
Sheng S, Zou M, Yang Y, Guan M, Ren S, Wang X, Wang L, Xue Y
In vitro cellular & developmental biology. Animal 2021 Sep;57(8):763-774
In vitro cellular & developmental biology. Animal 2021 Sep;57(8):763-774
Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury.
Li L, Liu S, Zhou Y, Zhao M, Wang Y, Wang C, Lou P, Huang R, Ma L, Lu Y, Fu P, Liu J
Journal of cellular and molecular medicine 2021 Oct;25(20):9863-9877
Journal of cellular and molecular medicine 2021 Oct;25(20):9863-9877
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.
Zhu J, Xin M, Xu C, He Y, Zhang W, Wang Z, Zhuang C
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3193-3205
A novel indazole derivative, compound Cyy-272, attenuates LPS-induced acute lung injury by inhibiting JNK phosphorylation.
Liu Q, Yan H, Zheng X, Fu L, Bao Y, Zheng H, Liu Z, Zhang X, Chen G
Toxicology and applied pharmacology 2021 Oct 1;428:115648
Toxicology and applied pharmacology 2021 Oct 1;428:115648
Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis.
Kitayama K, Kawamoto T, Kawakami Y, Hara H, Takemori T, Fujiwara S, Yahiro S, Miyamoto T, Mifune Y, Hoshino Y, Kakutani K, Matsumoto T, Matsushita T, Niikura T, Kuroda R, Akisue T
International journal of oncology 2021 Nov;59(5)
International journal of oncology 2021 Nov;59(5)
EGCG promotes PRKCA expression to alleviate LPS-induced acute lung injury and inflammatory response.
Wang M, Zhong H, Zhang X, Huang X, Wang J, Li Z, Chen M, Xiao Z
Scientific reports 2021 May 26;11(1):11014
Scientific reports 2021 May 26;11(1):11014
Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1.
Yao H, Shen H, Yu H, Wang C, Ding R, Lan X, Tash D, Wu X, Wang X, Zhang G
Physiology & behavior 2021 May 15;234:113387
Physiology & behavior 2021 May 15;234:113387
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Zhong H, Zhou Z, Guo L, Liu F, Zheng B, Bi S, Tian C
Mechanisms of ageing and development 2021 Mar;194:111417
Mechanisms of ageing and development 2021 Mar;194:111417
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Yang M, Cui Y, Song J, Cui C, Wang L, Liang K, Wang C, Sha S, He Q, Hu H, Guo X, Zang N, Sun L, Chen L
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Li D, Liu M, Li Z, Zheng G, Chen A, Zhao L, Yang P, Wei L, Chen Y, Ruan XZ
Aging and disease 2021 Jun;12(3):747-763
Aging and disease 2021 Jun;12(3):747-763
Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D.
Liu X, Li T, Liu Y, Sun S, Liu D
Toxicology 2021 Jun 15;457:152820
Toxicology 2021 Jun 15;457:152820
Damage to the blood‑brain barrier and activation of neuroinflammation by focal cerebral ischemia under hyperglycemic condition.
Guo Y, Dong L, Gong A, Zhang J, Jing L, Ding T, Li PA, Zhang JZ
International journal of molecular medicine 2021 Jul;48(1)
International journal of molecular medicine 2021 Jul;48(1)
Suppression of adenosine A(2a) receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide-induced cystitis by inhibiting TRPV1.
Yang Y, Zhang H, Lu Q, Liu X, Fan Y, Zhu J, Sun B, Zhao J, Dong X, Li L
Biochemical pharmacology 2021 Jan;183:114340
Biochemical pharmacology 2021 Jan;183:114340
Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions.
Liu H, Li Y, Sun S, Xin Q, Liu S, Mu X, Yuan X, Chen K, Wang H, Varga K, Mi W, Yang J, Zhang XD
Nature communications 2021 Jan 7;12(1):114
Nature communications 2021 Jan 7;12(1):114
Mesenchymal stem cell-derived exosome miR-542-3p suppresses inflammation and prevents cerebral infarction.
Cai G, Cai G, Zhou H, Zhuang Z, Liu K, Pei S, Wang Y, Wang H, Wang X, Xu S, Cui C, Sun M, Guo S, Jia K, Wang X, Zhang D
Stem cell research & therapy 2021 Jan 6;12(1):2
Stem cell research & therapy 2021 Jan 6;12(1):2
Polystyrene microplastics induced male reproductive toxicity in mice.
Jin H, Ma T, Sha X, Liu Z, Zhou Y, Meng X, Chen Y, Han X, Ding J
Journal of hazardous materials 2021 Jan 5;401:123430
Journal of hazardous materials 2021 Jan 5;401:123430
Dmrt1 regulates the immune response by repressing the TLR4 signaling pathway in goat male germline stem cells.
Wei YD, Du XM, Yang DH, Ma FL, Yu XW, Zhang MF, Li N, Peng S, Liao MZ, Li GP, Bai CL, Liu WS, Hua JL
Zoological research 2021 Jan 18;42(1):14-27
Zoological research 2021 Jan 18;42(1):14-27
Macrophages enhance lipopolysaccharide induced apoptosis via Ang1 and NF-κB pathways in human umbilical vein endothelial cells.
Cai GL, Yang ZX, Guo DY, Hu CB, Yan ML, Yan J
Scientific reports 2021 Feb 3;11(1):2918
Scientific reports 2021 Feb 3;11(1):2918
Integrative transcriptomic and metabonomic profiling analyses reveal the molecular mechanism of Chinese traditional medicine huankuile suspension on TNBS-induced ulcerative colitis.
Han Z, Wang H, Guo D, Zhang J
Aging 2021 Feb 1;13(4):5087-5103
Aging 2021 Feb 1;13(4):5087-5103
Cardamonin inhibits LPS-induced inflammatory responses and prevents acute lung injury by targeting myeloid differentiation factor 2.
Yang L, Luo W, Zhang Q, Hong S, Wang Y, Samorodov AV, Chattipakorn N, Pavlov VN, Liang G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153785
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153785
Links Between Gut Dysbiosis and Neurotransmitter Disturbance in Chronic Restraint Stress-Induced Depressive Behaviours: the Role of Inflammation.
Yang HL, Li MM, Zhou MF, Xu HS, Huan F, Liu N, Gao R, Wang J, Zhang N, Jiang L
Inflammation 2021 Dec;44(6):2448-2462
Inflammation 2021 Dec;44(6):2448-2462
Dual inhibition of EGFR and IL-6-STAT3 signalling by miR-146b: a potential targeted therapy for epithelial ovarian cancer.
Yan M, Han M, Yang X, Shen R, Wang H, Zhang L, Xia S, Yang P, Zhai G, Shao Q
Journal of enzyme inhibition and medicinal chemistry 2021 Dec;36(1):1905-1915
Journal of enzyme inhibition and medicinal chemistry 2021 Dec;36(1):1905-1915
Inhibitor of apoptosis-stimulating p53 protein protects against inflammatory bowel disease in mice models by inhibiting the nuclear factor kappa B signaling.
Qian K, Yuan L, Wang S, Kuang Y, Jin Q, Long D, Jiang Y, Zhao H, Liu K, Yao H
Clinical and experimental immunology 2021 Aug;205(2):246-256
Clinical and experimental immunology 2021 Aug;205(2):246-256
STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects psoriasis pathogenesis via regulating human keratinocyte proliferation.
Yang Z, Chen Z, Wang C, Huang P, Luo M, Zhou R
Cytokine 2021 Aug;144:155535
Cytokine 2021 Aug;144:155535
Follicle-stimulating hormone worsens osteoarthritis by causing inflammation and chondrocyte dedifferentiation.
Huan Z, Wang Y, Zhang M, Zhang X, Liu Y, Kong L, Xu J
FEBS open bio 2021 Aug;11(8):2292-2303
FEBS open bio 2021 Aug;11(8):2292-2303
Platelet membrane-camouflaged silver metal-organic framework drug system against infections caused by methicillin-resistant Staphylococcus aureus.
Huang R, Cai GQ, Li J, Li XS, Liu HT, Shang XL, Zhou JD, Nie XM, Gui R
Journal of nanobiotechnology 2021 Aug 4;19(1):229
Journal of nanobiotechnology 2021 Aug 4;19(1):229
Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.
Cui Y, Yang M, Wang Y, Ren J, Lin P, Cui C, Song J, He Q, Hu H, Wang K, Sun Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21485
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21485
Silencing lncRNA TUG1 Alleviates LPS-Induced Mouse Hepatocyte Inflammation by Targeting miR-140/TNF.
Liu QM, Liu LL, Li XD, Tian P, Xu H, Li ZL, Wang LK
Frontiers in cell and developmental biology 2020;8:616416
Frontiers in cell and developmental biology 2020;8:616416
Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation.
Fang Y, Li F, Qi C, Mao X, Wang F, Zhao Z, Chen JK, Zhang Z, Wu H
Cell death discovery 2020;6:52
Cell death discovery 2020;6:52
Role of Endoplasmic Reticulum Stress in Otitis Media.
Zhao H, Wang Y, Li B, Zheng T, Liu X, Hu BH, Che J, Zhao T, Chen J, Hatzoglou M, Zhang X, Fan Z, Zheng Q
Frontiers in genetics 2020;11:495
Frontiers in genetics 2020;11:495
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Xie T, Wang C, Jin Y, Meng Q, Liu Q, Wu J, Sun H
Frontiers in pharmacology 2020;11:1034
Frontiers in pharmacology 2020;11:1034
Tacrolimus ameliorates tubulointerstitial inflammation in diabetic nephropathy via inhibiting the NFATc1/TRPC6 pathway.
Zhang S, Wang H, Liu Y, Yang W, Liu J, Han Y, Liu Y, Liu F, Sun L, Xiao L
Journal of cellular and molecular medicine 2020 Sep;24(17):9810-9824
Journal of cellular and molecular medicine 2020 Sep;24(17):9810-9824
Non-neuronal crosstalk promotes an inflammatory response in nodose ganglia cultures after exposure to byproducts from gram positive, high-fat-diet-associated gut bacteria.
Cawthon CR, Kirkland RA, Pandya S, Brinson NA, de La Serre CB
Physiology & behavior 2020 Nov 1;226:113124
Physiology & behavior 2020 Nov 1;226:113124
The USP14-NLRC5 pathway inhibits titanium particle-induced osteolysis in mice by suppressing NF-κB and PI3K/AKT activities.
Fang G, Fu Y, Li S, Qiu J, Kuang M, Lin S, Li C, Ding Y
The Journal of biological chemistry 2020 May 15;295(20):7018-7032
The Journal of biological chemistry 2020 May 15;295(20):7018-7032
Ophiocordyceps lanpingensis polysaccharides attenuate pulmonary fibrosis in mice.
Zhou S, Zhou Y, Yu J, Du Y, Tan Y, Ke Y, Wang J, Han B, Ge F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110058
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110058
Wu-Mei-Wan prevents high-fat diet-induced obesity by reducing white adipose tissue and enhancing brown adipose tissue function.
Wu F, Yang X, Hu M, Shao Q, Fang K, Li J, Zhao Y, Xu L, Zou X, Lu F, Chen G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Jun 3;76:153258
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Jun 3;76:153258
Major depression accompanied with inflammation and multiple cytokines alterations: Evidences from clinical patients to macaca fascicularis and LPS-induced depressive mice model.
He Y, Li W, Wang Y, Tian Y, Chen X, Wu Z, Lan T, Li Y, Bai M, Liu J, Cheng K, Xie P
Journal of affective disorders 2020 Jun 15;271:262-271
Journal of affective disorders 2020 Jun 15;271:262-271
A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos.
Zhang Z, Hou WB, Zhang C, Tan YE, Zhang DD, An W, Pan SW, Wu WD, Chen QC, Xu HM
Journal of cellular and molecular medicine 2020 Dec;24(24):14217-14230
Journal of cellular and molecular medicine 2020 Dec;24(24):14217-14230
Silencing of lncRNA MIAT alleviates LPS-induced pneumonia via regulating miR-147a/NKAP/NF-κB axis.
Liu M, Li W, Song F, Zhang L, Sun X
Aging 2020 Dec 9;13(2):2506-2518
Aging 2020 Dec 9;13(2):2506-2518
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Gao F, Zuo B, Wang Y, Li S, Yang J, Sun D
Life sciences 2020 Aug 15;255:117719
Life sciences 2020 Aug 15;255:117719
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Yang K, Lu T, Zhan L, Zhou C, Zhang N, Lei S, Wang Y, Yang J, Yan M, Lv G, Chen S
International journal of biological macromolecules 2020 Apr 15;149:320-330
International journal of biological macromolecules 2020 Apr 15;149:320-330
Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro.
Du Y, Qian B, Gao L, Tan P, Chen H, Wang A, Zheng T, Pu S, Xia X, Fu W
Oxidative medicine and cellular longevity 2019;2019:3765898
Oxidative medicine and cellular longevity 2019;2019:3765898
Apigenin Inhibits IL-6 Transcription and Suppresses Esophageal Carcinogenesis.
Qiu JG, Wang L, Liu WJ, Wang JF, Zhao EJ, Zhou FM, Ji XB, Wang LH, Xia ZK, Wang W, Lin MC, Liu LZ, Huang YX, Jiang BH
Frontiers in pharmacology 2019;10:1002
Frontiers in pharmacology 2019;10:1002
Inhibition of the mitochondrial complex-1 protects against carbon tetrachloride-induced acute liver injury.
Hua H, Zhang Z, Qian Y, Yuan H, Ge W, Huang S, Zhang A, Zhang Y, Jia Z, Ding G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108948
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108948
Repair Effects of Astragalus Polysaccharides with Different Molecular Weights on Oxidatively Damaged HK-2 Cells.
Han J, Guo D, Sun XY, Wang JM, Ouyang JM, Gui BS
Scientific reports 2019 Jul 8;9(1):9871
Scientific reports 2019 Jul 8;9(1):9871
Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells.
Yang L, Tucker D, Dong Y, Wu C, Lu Y, Li Y, Zhang J, Liu TC, Zhang Q
Experimental neurology 2018 Jan;299(Pt A):86-96
Experimental neurology 2018 Jan;299(Pt A):86-96
Clinicopathological significance of overexpression of interleukin-6 in colorectal cancer.
Zeng J, Tang ZH, Liu S, Guo SS
World journal of gastroenterology 2017 Mar 14;23(10):1780-1786
World journal of gastroenterology 2017 Mar 14;23(10):1780-1786
Upregulated Expression of microRNA-16 Correlates with Th17/Treg Cell Imbalance in Patients with Rheumatoid Arthritis.
Wu YH, Liu W, Xue B, Zhang L, Liu XY, Liu B, Wang Y, Cai Y, Duan R
DNA and cell biology 2016 Dec;35(12):853-860
DNA and cell biology 2016 Dec;35(12):853-860
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Recombinant protein were subjected to SDS PAGE followed by western blot with 66146-1-Ig(IL6 antibody) at dilution of 1:10000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IL-6 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human IL-6. This antibody recognizes human antigen. The IL-6 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
