Antibody data
- Antibody Data
- Antigen structure
- References [74]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 66192-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- ERK1/2 antibody
- Antibody type
- Monoclonal
- Description
- ERK1/2 antibody (Cat. #66192-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4G8A11
- Vial size
- 20ul, 150ul
Submitted references INHBA Promotes the Progression of Gastric Cancer by Activating MAPK Signaling Pathway via Targeting ITGA6.
A fibroblast-specific miRNA functional cluster in remote exosomes aggravates myocardial ischaemia/reperfusion injury via the Rap1b/ERK1/2 axis.
The interaction between NPMc+ and Orai1 induces abnormal calcium influx to facilitate leukemogenesis.
Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification.
Impaired testicular development in male offspring following gestational DEHP exposure: The role of macrophage-Leydig cell axis.
Hepatic cavernous hemangioma decellularized extracellular matrix/GelMA composite hydrogel promotes angiogenesis via the ITGA9-FAK-ERK1/2 axis.
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
The promoting roles of GLP1R and GIPR in stemness maintenance and multiple lineage-specific differentiation of PDLSCs.
An evaluation of the anti-human respiratory syncytial virus activity of sophora alkaloids and the enhanced efficacy by liposomes via intratracheal administration.
USP1 dependent stabilization of LTA4H drives hepatocellular carcinoma angiogenesis.
Mechanistic insights into the effect of midazolam on the malignant progression of ovarian cancer.
Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation.
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells.
TGF-β-activated NK-92 cell therapy for esophageal squamous cell carcinoma.
EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.
Rg1-preconditioned adipose-derived mesenchymal stromal cells alleviate colitis via exosome-mediated Inhibition of macrophage glycolysis through RAS signaling.
Disruption of axonal transport in Parkinson's disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling.
GTF3C2 Promotes the Proliferation of Hepatocellular Carcinoma Cells through the USP21/MEK2/ERK1/2 Pathway.
Targeting CCR5 with miltefosine as a therapeutic strategy for thrombocytopenia.
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
Downregulation of miR-27a-3p induces endothelial injury and senescence and its significance in the development of coronary heart disease.
The KSR1/MEK/ERK signaling pathway promotes the progression of intrauterine adhesions.
A novel therapeutic strategy for leukopenia: Miltefosine activates the Ras/MEK/ERK pathway to promote neutrophil differentiation.
The prognostic and immune significance of Rab11A in pan-cancer and its function and mechanism underlying estrogen receptor targeting in breast cancer.
Integrative analysis of 5-methylcytosine associated signature in papillary thyroid cancer.
TAT and RVG Co-modified MSC-derived Exosomes-mediated Delivery of microRNA-15b-5p Inhibitor Alleviate Cerebral Ischemia and Reperfusion-induced Neuronal Apoptosis by Promoting HTR2C-ERK Signaling.
DL-3-n-Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing GCN5L1-Mediated Drp1 Acetylation in Neurons and Mouse Brains.
A novel lncRNA, Lnc21q22.11, suppresses gastric cancer growth by inhibiting MEK/ERK pathway.
miR-196a-5p suppresses the MAPK/ERK pathway by targeting HOXA7 to regulate the proliferation and apoptosis of placental trophoblasts in gestational diabetes.
Derazantinib enhances gemcitabine efficacy in PDAC by attenuating the NF-κB and MAPK pathways to suppress MUC5AC expression.
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod-induced psoriasiform inflammation via STAT1/S100A9 signalling pathway.
Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy.
tRF-34-P4R8YP9LON4VHM Promotes Hepatocellular Carcinoma Progression and Tumour Cell-Induced Angiogenesis via the MEK/ERK Pathway.
PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer.
Retinol Binding Protein 4 Serves as a Potential Tumor Biomarker and Promotes Malignant Behavior in Gastric Cancer.
Overexpression of the Mas1 gene mitigated LPS-induced inflammatory injury in mammary epithelial cells by inhibiting the NF-κB/MAPKs signaling pathways.
Yeast β-glucan-based nanoparticles loading methotrexate promotes osteogenesis of hDPSCs and periodontal bone regeneration under the inflammatory microenvironment.
Exosomal miR-552-3p isolated from BALF of patients with silicosis induces fibroblast activation.
Excessive Supplement of l-Arginine Induces Myopia via Orchestrating the MEK-ERK-NO Signaling Pathway.
BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo.
Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
Downregulation of microRNA‑221‑3p promotes angiogenesis of lipoprotein(a)‑injured endothelial progenitor cells by targeting silent information regulator 1 to activate the RAF/MEK/ERK signaling pathway.
Ccl2-Induced Regulatory T Cells Balance Inflammation Through Macrophage Polarization During Liver Reconstitution.
The ellagitannin metabolite urolithin C attenuated cognitive impairment by inhibiting neuroinflammation via downregulation of MAPK/NF-kB signaling pathways in aging mice.
Preventive effects of matrine on LPS-induced inflammation in RAW 264.7 cells and intestinal damage in mice through the TLR4/NF-κB/MAPK pathway.
Integrated network toxicology, molecular docking, and in vivo experiments to elucidate molecular mechanism of aflatoxin B1 hepatotoxicity.
SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice.
An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma.
Carbon Ions Suppress Angiogenesis and Lung Metastases in Melanoma by Targeting CXCL10.
Asebogenin suppresses thrombus formation via inhibition of Syk phosphorylation.
ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3.
CLDN4 promotes growth of acute myeloid leukemia cells via regulating AKT and ERK1/2 signaling.
Milk Exosomal miR-27b Worsen Endoplasmic Reticulum Stress Mediated Colorectal Cancer Cell Death.
Selenium Restores Synaptic Deficits by Modulating NMDA Receptors and Selenoprotein K in an Alzheimer's Disease Model.
Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma.
Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection.
DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.
CiRS-7 functions as a ceRNA of RAF-1/PIK3CD to promote metastatic progression of oral squamous cell carcinoma via MAPK/AKT signaling pathways.
mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.
An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway.
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis.
Preferential Small Intestine Homing and Persistence of CD8 T Cells in Rhesus Macaques Achieved by Molecularly Engineered Expression of CCR9 and Reduced Ex Vivo Manipulation.
Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway.
mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1ins subunit in spinal dorsal horn of mice.
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin-Axin2-GSK3β Signaling Pathway.
RPN2 promotes colorectal cancer cell proliferation through modulating the glycosylation status of EGFR.
Pro-invasive stimuli and the interacting protein Hsp70 favour the route of alpha-enolase to the cell surface.
CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering.
ERK-mediated NF-κB activation through ASIC1 in response to acidosis.
Amphiregulin mediates hCG-induced StAR expression and progesterone production in human granulosa cells.
A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway.
miR-223 Regulates Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells Through a C/EBPs/miR-223/FGFR2 Regulatory Feedback Loop.
Zhou G, Zhang R, Nie L, Si Y, Liu T, Wang J, Han S, Xuan M, Wang J, Yu W
Oncology research 2026;34(3):25
Oncology research 2026;34(3):25
A fibroblast-specific miRNA functional cluster in remote exosomes aggravates myocardial ischaemia/reperfusion injury via the Rap1b/ERK1/2 axis.
Zhang R, Li M, Jin J, Fu X, Zhu H, Huang X, He M, Li Z, Lin R, Lin H, Zhang T, Liao W, Bin J, Wang Q, Zheng C, Liao Y
British journal of pharmacology 2026 Mar;183(5):1186-1204
British journal of pharmacology 2026 Mar;183(5):1186-1204
The interaction between NPMc+ and Orai1 induces abnormal calcium influx to facilitate leukemogenesis.
Zhang W, Liang C, Zhang L, Liu X, Zhang Z, Guo H, Jia J, Chen X, Shang H, Zheng X, Qin J, Li S, Liu D, Wu F
The FEBS journal 2026 Mar 24;
The FEBS journal 2026 Mar 24;
Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification.
Li Z, Zhao M, Xi Z, Bai J, Zhang Y, Zhan X, Yang Y, Liu Y
Cell chemical biology 2026 Mar 20;
Cell chemical biology 2026 Mar 20;
Impaired testicular development in male offspring following gestational DEHP exposure: The role of macrophage-Leydig cell axis.
Ye S, Wu S, Yuan G, Xu J, Cai B, Chen J, Ge W
Ecotoxicology and environmental safety 2026 Mar 15;313:120017
Ecotoxicology and environmental safety 2026 Mar 15;313:120017
Hepatic cavernous hemangioma decellularized extracellular matrix/GelMA composite hydrogel promotes angiogenesis via the ITGA9-FAK-ERK1/2 axis.
Dai Z, Li X, Jin M, Liu W, Li X, Zhang C, Li F, Lin J, Zhou Z, Sun X, Wang T, Yang H, Zhang J
Materials today. Bio 2026 Jun;38:102976
Materials today. Bio 2026 Jun;38:102976
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
Ni J, Zhou H, Shen K, Xu H, Wang J, Liu J, Liu F
Journal of translational medicine 2026 Feb 26;24(1)
Journal of translational medicine 2026 Feb 26;24(1)
The promoting roles of GLP1R and GIPR in stemness maintenance and multiple lineage-specific differentiation of PDLSCs.
Shen Y, Zhang M, Yang T, Wu Y, Qiu Y, Zhang L, Li F, Chen M, Chen Q, Wei W, Li H, Shen Y
Cellular & molecular biology letters 2026 Feb 11;31(1):22
Cellular & molecular biology letters 2026 Feb 11;31(1):22
An evaluation of the anti-human respiratory syncytial virus activity of sophora alkaloids and the enhanced efficacy by liposomes via intratracheal administration.
Wang G, Zhang K, Huang L, Liu C, Hu S, Luo Y, Gong Z, Peng J
Colloids and surfaces. B, Biointerfaces 2026 Apr 9;265:115697
Colloids and surfaces. B, Biointerfaces 2026 Apr 9;265:115697
USP1 dependent stabilization of LTA4H drives hepatocellular carcinoma angiogenesis.
Xu B, Wang Y, Lin Z, Chen W, Liu M, Tang Z, Ma K, Jiang L, Zheng W, Bian S
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 25;1872(6):168270
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 25;1872(6):168270
Mechanistic insights into the effect of midazolam on the malignant progression of ovarian cancer.
Sun X, Yu H, Fu B, Zhang Y
CytoJournal 2025;22:91
CytoJournal 2025;22:91
Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation.
Xi P, Zeng D, Chen M, Jiang L, Zhang Y, Qin D, Yao Z, He C
Frontiers in immunology 2025;16:1546242
Frontiers in immunology 2025;16:1546242
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells.
Liu J, Shu T, Mu Y, Zheng W, Lu X, Tao H
Frontiers in immunology 2025;16:1503355
Frontiers in immunology 2025;16:1503355
TGF-β-activated NK-92 cell therapy for esophageal squamous cell carcinoma.
Zhang H, Guo M, Zhai Y, Li F, Hu W, Zhang Y, Yang S, Huang L
International immunopharmacology 2025 Oct 30;164:115329
International immunopharmacology 2025 Oct 30;164:115329
EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.
Wang D, Liu Y, Chen Y, Dai C, Hu W, Han J, Li Z, Yin F, Zhang Y, Shi C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e10197
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e10197
Rg1-preconditioned adipose-derived mesenchymal stromal cells alleviate colitis via exosome-mediated Inhibition of macrophage glycolysis through RAS signaling.
Fang Y, Chen Y, Yu X, Zhang J, Zhu W, Mou C, Wang D, Chen A, Zhang R, Liu Q, Li T, Jiang B
Stem cell research & therapy 2025 Nov 28;17(1):68
Stem cell research & therapy 2025 Nov 28;17(1):68
Disruption of axonal transport in Parkinson's disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling.
Yang X, Ma Z, Lian P, Wu Y, Liu K, Zhang Z, Tang Z, Xu Y, Cao X
NPJ Parkinson's disease 2025 May 6;11(1):114
NPJ Parkinson's disease 2025 May 6;11(1):114
GTF3C2 Promotes the Proliferation of Hepatocellular Carcinoma Cells through the USP21/MEK2/ERK1/2 Pathway.
Wu Y, Yang Y, Zhang Y, Xu Q, Huang D, Tu K
Journal of clinical and translational hepatology 2025 May 28;13(5):374-384
Journal of clinical and translational hepatology 2025 May 28;13(5):374-384
Targeting CCR5 with miltefosine as a therapeutic strategy for thrombocytopenia.
Li Q, Zhang T, Li Z, Qi X, Mei X, Liu S, He S, Qiao G, Li R, Shen H, Zeng J, Huang F, Dai S, Li S, Luo J, Wu J, Wang L
iScience 2025 May 16;28(5):112379
iScience 2025 May 16;28(5):112379
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
Ma Z, Xu Y, Lian P, Wu Y, Liu K, Zhang Z, Tang Z, Yang X, Cao X
Neuroscience bulletin 2025 Jun;41(6):951-969
Neuroscience bulletin 2025 Jun;41(6):951-969
Downregulation of miR-27a-3p induces endothelial injury and senescence and its significance in the development of coronary heart disease.
Song CY, Huang HZ, Yan TT, Cui CX, Wu HY, Chen J, Peng JH, Chen NY, Tang J, Pan SL
Cellular signalling 2025 Jul;131:111759
Cellular signalling 2025 Jul;131:111759
The KSR1/MEK/ERK signaling pathway promotes the progression of intrauterine adhesions.
Wu S, Chen Q, Yang X, Zhang L, Huang X, Huang J, Wu J, Sun C, Zhang W, Wang J
Cellular signalling 2025 Jul;131:111730
Cellular signalling 2025 Jul;131:111730
A novel therapeutic strategy for leukopenia: Miltefosine activates the Ras/MEK/ERK pathway to promote neutrophil differentiation.
Li Q, He S, Li Z, Liu S, Mei X, Qi X, Qiao G, Luo J, Shen H, Zeng J, Huang F, Gong S, Chen Z, Wu J, Wang L
Biochemical and biophysical research communications 2025 Feb;746:151239
Biochemical and biophysical research communications 2025 Feb;746:151239
The prognostic and immune significance of Rab11A in pan-cancer and its function and mechanism underlying estrogen receptor targeting in breast cancer.
Li Y, Ding B, Wei M, Yang X, Fu R, Liu Y, Zhu L, Ding Y, Zhang W, Zhang G, Zhang S, Bu Y, He J, Deng J, Bao X, Hao J, Ma L
Asia-Pacific journal of clinical oncology 2025 Feb;21(1):12-30
Asia-Pacific journal of clinical oncology 2025 Feb;21(1):12-30
Integrative analysis of 5-methylcytosine associated signature in papillary thyroid cancer.
Ding Y, Li X, Wang W, Cai L
Scientific reports 2025 Feb 5;15(1):4405
Scientific reports 2025 Feb 5;15(1):4405
TAT and RVG Co-modified MSC-derived Exosomes-mediated Delivery of microRNA-15b-5p Inhibitor Alleviate Cerebral Ischemia and Reperfusion-induced Neuronal Apoptosis by Promoting HTR2C-ERK Signaling.
You G, Chen X, Ma X, Tang X, Zheng Y, Lin W, Li Y, Yao H, Zan J, Ding Y
Molecular neurobiology 2025 Dec;62(12):15813-15831
Molecular neurobiology 2025 Dec;62(12):15813-15831
DL-3-n-Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing GCN5L1-Mediated Drp1 Acetylation in Neurons and Mouse Brains.
Zhang H, Zhang N, Yang X, Zhang J, Ge X, Wang L, Wang S, Wen Y
CNS neuroscience & therapeutics 2025 Dec;31(12):e70682
CNS neuroscience & therapeutics 2025 Dec;31(12):e70682
A novel lncRNA, Lnc21q22.11, suppresses gastric cancer growth by inhibiting MEK/ERK pathway.
Zhu C, Zhang M, Yang W, Gao A, Yu X, Su X, Chen R, Guo M
Epigenetics 2025 Dec;20(1):2512764
Epigenetics 2025 Dec;20(1):2512764
miR-196a-5p suppresses the MAPK/ERK pathway by targeting HOXA7 to regulate the proliferation and apoptosis of placental trophoblasts in gestational diabetes.
Li J, Xie X, Lu L, Gan B, Yan J
Placenta 2025 Dec;172:167-178
Placenta 2025 Dec;172:167-178
Derazantinib enhances gemcitabine efficacy in PDAC by attenuating the NF-κB and MAPK pathways to suppress MUC5AC expression.
Ye W, Huang Y, Hong L, Ma Y, Huang J, Xu F, Han F, Qiu Y, Zou Z, Zhang Y, Li X
Medical oncology (Northwood, London, England) 2025 Dec 30;43(2):107
Medical oncology (Northwood, London, England) 2025 Dec 30;43(2):107
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod-induced psoriasiform inflammation via STAT1/S100A9 signalling pathway.
Nie YW, Liu X, Peng Y, Zhang CY, Xi RF, Jiang XX, Wang Y, Lu HZ, Guo DJ, Guo WJ, Duan YJ, Nian H, Wang K, Chen JY, Li FL, Zhu JY
British journal of pharmacology 2025 Aug;182(16):3884-3902
British journal of pharmacology 2025 Aug;182(16):3884-3902
Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy.
Wei Y, Sun MM, Zhang RL, Wang L, Yang LH, Shan CL, Lin JP
Acta pharmacologica Sinica 2025 Apr;46(4):1030-1044
Acta pharmacologica Sinica 2025 Apr;46(4):1030-1044
tRF-34-P4R8YP9LON4VHM Promotes Hepatocellular Carcinoma Progression and Tumour Cell-Induced Angiogenesis via the MEK/ERK Pathway.
Xu T, Hua H, Song F, Zhang N, Gao C, Chen Z
Journal of cellular and molecular medicine 2025 Apr;29(8):e70560
Journal of cellular and molecular medicine 2025 Apr;29(8):e70560
PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer.
Huang ZJ, Li YJ, Yang J, Huang L, Zhao Q, Lu YF, Hu Y, Zhang WX, Liang JZ, Pan J, Pan YL, He QY, Wang Y
International journal of biological sciences 2024;20(6):2202-2218
International journal of biological sciences 2024;20(6):2202-2218
Retinol Binding Protein 4 Serves as a Potential Tumor Biomarker and Promotes Malignant Behavior in Gastric Cancer.
Yu Y, Zhang C, Sun Q, Baral S, Ding J, Zhao F, Yao Q, Gao S, Liu B, Wang D
Cancer management and research 2024;16:891-908
Cancer management and research 2024;16:891-908
Overexpression of the Mas1 gene mitigated LPS-induced inflammatory injury in mammary epithelial cells by inhibiting the NF-κB/MAPKs signaling pathways.
Yan S, Ju X, Lao J, Wen Z, Yong Y, Li Y, Li Y
Frontiers in veterinary science 2024;11:1446366
Frontiers in veterinary science 2024;11:1446366
Yeast β-glucan-based nanoparticles loading methotrexate promotes osteogenesis of hDPSCs and periodontal bone regeneration under the inflammatory microenvironment.
Chen H, Liu N, Hu S, Li X, He F, Chen L, Xu X
Carbohydrate polymers 2024 Oct 15;342:122401
Carbohydrate polymers 2024 Oct 15;342:122401
Exosomal miR-552-3p isolated from BALF of patients with silicosis induces fibroblast activation.
Li M, Li Y, Liu Q, Jiang M, He Y, Liao X, Tao L, Meng J
Toxicology letters 2024 Nov;401:55-70
Toxicology letters 2024 Nov;401:55-70
Excessive Supplement of l-Arginine Induces Myopia via Orchestrating the MEK-ERK-NO Signaling Pathway.
Bao B, Liu J, Xin J, Zhou X, Zhang R, Hao J, Yang Z, Zhang M, Ma Z, Yin X, Bi H, Guo D
Journal of agricultural and food chemistry 2024 Nov 27;72(47):26462-26474
Journal of agricultural and food chemistry 2024 Nov 27;72(47):26462-26474
BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo.
Yang Q, To KKW, Hu G, Fu K, Yang C, Zhu S, Pan C, Wang F, Luo K, Fu L
Cell communication and signaling : CCS 2024 Jun 13;22(1):325
Cell communication and signaling : CCS 2024 Jun 13;22(1):325
Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
Wang J, Li DL, Zheng LF, Ren S, Huang ZQ, Tao Y, Liu Z, Shang Y, Pang D, Guo H, Zeng T, Wang HR, Huang H, Du X, Ye H, Zhou HM, Li P, Zhao TJ
Developmental cell 2024 Feb 5;59(3):384-399.e5
Developmental cell 2024 Feb 5;59(3):384-399.e5
Downregulation of microRNA‑221‑3p promotes angiogenesis of lipoprotein(a)‑injured endothelial progenitor cells by targeting silent information regulator 1 to activate the RAF/MEK/ERK signaling pathway.
Zhang X, Wang S, Qin Y, Guo H
Molecular medicine reports 2024 Dec;30(6)
Molecular medicine reports 2024 Dec;30(6)
Ccl2-Induced Regulatory T Cells Balance Inflammation Through Macrophage Polarization During Liver Reconstitution.
Wang R, Liang Q, Zhang Q, Zhao S, Lin Y, Liu B, Ma Y, Mai X, Fu Q, Bao X, Wang N, Chen B, Yan P, Zhu Y, Wang K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(45):e2403849
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(45):e2403849
The ellagitannin metabolite urolithin C attenuated cognitive impairment by inhibiting neuroinflammation via downregulation of MAPK/NF-kB signaling pathways in aging mice.
Chen P, Wu L, Lei J, Chen F, Feng L, Liu G, Zhou B
International immunopharmacology 2024 Dec 5;142(Pt B):113151
International immunopharmacology 2024 Dec 5;142(Pt B):113151
Preventive effects of matrine on LPS-induced inflammation in RAW 264.7 cells and intestinal damage in mice through the TLR4/NF-κB/MAPK pathway.
Mao N, Yu Y, Lu X, Yang Y, Liu Z, Wang D
International immunopharmacology 2024 Dec 25;143(Pt 2):113432
International immunopharmacology 2024 Dec 25;143(Pt 2):113432
Integrated network toxicology, molecular docking, and in vivo experiments to elucidate molecular mechanism of aflatoxin B1 hepatotoxicity.
Ge B, Yan K, Sang R, Wang W, Liu X, Yu M, Liu X, Qiu Q, Zhang X
Ecotoxicology and environmental safety 2024 Apr 15;275:116278
Ecotoxicology and environmental safety 2024 Apr 15;275:116278
SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice.
Du X, Yan Y, Yu J, Zhu T, Huang CC, Zhang L, Shan X, Li R, Dai Y, Lv H, Zhang XY, Feng J, Li WG, Luo Q, Li F
Research (Washington, D.C.) 2023;6:0269
Research (Washington, D.C.) 2023;6:0269
An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma.
Oyelakin A, Sosa J, Nayak KB, Glathar A, Gluck C, Sethi I, Tsompana M, Nowak N, Buck M, Romano RA, Sinha S
NAR cancer 2023 Sep;5(3):zcad038
NAR cancer 2023 Sep;5(3):zcad038
Carbon Ions Suppress Angiogenesis and Lung Metastases in Melanoma by Targeting CXCL10.
Li C, Zhang Q, Luo H, Liu R, Feng S, Geng Y, Wang L, Yang Z, Zhang Y, Wang X
Radiation research 2023 Sep 1;200(3):307-319
Radiation research 2023 Sep 1;200(3):307-319
Asebogenin suppresses thrombus formation via inhibition of Syk phosphorylation.
Li L, Xu X, Lv K, Zheng G, Wang H, Chen S, Huang L, Liu Y, Zhang Y, Tang Z, Zhang L, Wang J, Qiao J, Li H, Wang X, Yao G, Fang C
British journal of pharmacology 2023 Feb;180(3):287-307
British journal of pharmacology 2023 Feb;180(3):287-307
ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3.
Hu M, Bao R, Lin M, Han XR, Ai YJ, Gao Y, Guan KL, Xiong Y, Yuan HX
Oncogene 2022 Sep;41(40):4547-4559
Oncogene 2022 Sep;41(40):4547-4559
CLDN4 promotes growth of acute myeloid leukemia cells via regulating AKT and ERK1/2 signaling.
Hao S, Yang C, Song P, Shi H, Zou Y, Chen M, Wu X, Yin Y, Yu Z, Zhu W, Li M
Biochemical and biophysical research communications 2022 Sep 3;619:137-143
Biochemical and biophysical research communications 2022 Sep 3;619:137-143
Milk Exosomal miR-27b Worsen Endoplasmic Reticulum Stress Mediated Colorectal Cancer Cell Death.
Martino E, Balestrieri A, Mele L, Sardu C, Marfella R, D'Onofrio N, Campanile G, Balestrieri ML
Nutrients 2022 Nov 29;14(23)
Nutrients 2022 Nov 29;14(23)
Selenium Restores Synaptic Deficits by Modulating NMDA Receptors and Selenoprotein K in an Alzheimer's Disease Model.
Zhang ZH, Chen C, Jia SZ, Cao XC, Liu M, Tian J, Hoffmann PR, Xu HX, Ni JZ, Song GL
Antioxidants & redox signaling 2021 Oct 10;35(11):863-884
Antioxidants & redox signaling 2021 Oct 10;35(11):863-884
Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma.
Wang C, Wang X, Han A, Wang Y, Jiang H
Experimental and therapeutic medicine 2021 May;21(5):470
Experimental and therapeutic medicine 2021 May;21(5):470
Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection.
Chen S, Lv K, Sharda A, Deng J, Zeng W, Zhang C, Hu Q, Jin P, Yao G, Xu X, Ming Z, Fang C
Pharmacological research 2021 May;167:105540
Pharmacological research 2021 May;167:105540
DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.
Wang X, Wang HY, Hu GS, Tang WS, Weng L, Zhang Y, Guo H, Yao SS, Liu SY, Zhang GL, Han Y, Liu M, Zhang XD, Cen X, Shen HF, Xiao N, Liu CQ, Wang HR, Huang J, Liu W, Li P, Zhao TJ
Cell reports 2021 Jun 22;35(12):109281
Cell reports 2021 Jun 22;35(12):109281
CiRS-7 functions as a ceRNA of RAF-1/PIK3CD to promote metastatic progression of oral squamous cell carcinoma via MAPK/AKT signaling pathways.
Dou Z, Gao L, Ren W, Zhang H, Wang X, Li S, Zheng J, Kong X, Chi P, Zhi K
Experimental cell research 2020 Nov 15;396(2):112290
Experimental cell research 2020 Nov 15;396(2):112290
mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.
Ding H, Song Y, Huang X, Wang L, Luo S, Zhang H, Pan H, Jiang W, Qian J, Yao G, Wen L, Zhang Y
Biomaterials science 2020 Jul 28;8(15):4358-4369
Biomaterials science 2020 Jul 28;8(15):4358-4369
An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway.
Yang ZY, Yang L, Xu CW, Wang XJ, Lei L
Biology open 2020 Jan 24;9(1)
Biology open 2020 Jan 24;9(1)
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
Chen X, Ji S, Si J, Zhang X, Wang X, Guo Y, Zou X
Molecular medicine reports 2020 Dec;22(6):5243-5250
Molecular medicine reports 2020 Dec;22(6):5243-5250
lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis.
Ge Y, Wang J, Wu D, Zhou Y, Qiu S, Chen J, Zhu X, Xiang X, Li H, Zhang D
Molecular therapy. Nucleic acids 2019 Sep 6;17:741-753
Molecular therapy. Nucleic acids 2019 Sep 6;17:741-753
Preferential Small Intestine Homing and Persistence of CD8 T Cells in Rhesus Macaques Achieved by Molecularly Engineered Expression of CCR9 and Reduced Ex Vivo Manipulation.
Trivett MT, Burke JD, Deleage C, Coren LV, Hill BJ, Jain S, Barsov EV, Breed MW, Kramer JA, Del Prete GQ, Lifson JD, Swanstrom AE, Ott DE
Journal of virology 2019 Nov 1;93(21)
Journal of virology 2019 Nov 1;93(21)
Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway.
Yanchun M, Yi W, Lu W, Yu Q, Jian Y, Pengzhou K, Ting Y, Hongyi L, Fang W, Xiaolong C, Yongping C
European journal of pharmacology 2019 May 15;851:43-51
European journal of pharmacology 2019 May 15;851:43-51
mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1ins subunit in spinal dorsal horn of mice.
Zhang ZY, Bai HH, Guo Z, Li HL, He YT, Duan XL, Suo ZW, Yang X, He YX, Hu XD
PLoS biology 2019 Aug;17(8):e3000371
PLoS biology 2019 Aug;17(8):e3000371
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Wang AL, Li Y, Zhao Q, Fan LQ
Molecular medicine reports 2018 Jun;17(6):7721-7729
Molecular medicine reports 2018 Jun;17(6):7721-7729
Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin-Axin2-GSK3β Signaling Pathway.
Xie YY, Mo CL, Cai YH, Wang WJ, Hong XX, Zhang KK, Liu QF, Liu YJ, Hong JJ, He T, Zheng ZZ, Mo W, Li BA
Diabetes 2018 Dec;67(12):2569-2584
Diabetes 2018 Dec;67(12):2569-2584
RPN2 promotes colorectal cancer cell proliferation through modulating the glycosylation status of EGFR.
Li H, Al-Japairai K, Tao Y, Xiang Z
Oncotarget 2017 Sep 22;8(42):72633-72651
Oncotarget 2017 Sep 22;8(42):72633-72651
Pro-invasive stimuli and the interacting protein Hsp70 favour the route of alpha-enolase to the cell surface.
Perconti G, Maranto C, Romancino DP, Rubino P, Feo S, Bongiovanni A, Giallongo A
Scientific reports 2017 Jun 19;7(1):3841
Scientific reports 2017 Jun 19;7(1):3841
CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering.
Ayala VI, Deleage C, Trivett MT, Jain S, Coren LV, Breed MW, Kramer JA, Thomas JA, Estes JD, Lifson JD, Ott DE
Journal of virology 2017 Jun 1;91(11)
Journal of virology 2017 Jun 1;91(11)
ERK-mediated NF-κB activation through ASIC1 in response to acidosis.
Chen B, Liu J, Ho TT, Ding X, Mo YY
Oncogenesis 2016 Dec 12;5(12):e279
Oncogenesis 2016 Dec 12;5(12):e279
Amphiregulin mediates hCG-induced StAR expression and progesterone production in human granulosa cells.
Fang L, Yu Y, Zhang R, He J, Sun YP
Scientific reports 2016 Apr 26;6:24917
Scientific reports 2016 Apr 26;6:24917
A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway.
Sun L, Xu C, Chen G, Yu M, Yang S, Qiu Y, Peng K, Wang W, Xiao W, Yang H
International journal of biological sciences 2015;11(6):664-71
International journal of biological sciences 2015;11(6):664-71
miR-223 Regulates Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells Through a C/EBPs/miR-223/FGFR2 Regulatory Feedback Loop.
Guan X, Gao Y, Zhou J, Wang J, Zheng F, Guo F, Chang A, Li X, Wang B
Stem cells (Dayton, Ohio) 2015 May;33(5):1589-600
Stem cells (Dayton, Ohio) 2015 May;33(5):1589-600
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The ERK1/2 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human ERK1/2. This antibody recognizes human, mouse antigen. The ERK1/2 antibody has been validated for the following applications: ELISA, WB analysis.