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- Antigen structure
- References [308]
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- Product number
- 11257-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11257-1-AP, RRID:AB_2139822
- Product name
- ERK1/2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ERK1/2 antibody (Cat. #11257-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Qingfei Formula Protects against Human Respiratory Syn cytial Virus-induced Lung Inflammatory Injury by Regulating the M APK Signaling Pathway.
miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK.
Dual role of CD73 as a signaling molecule and adenosine-generating enzyme in colorectal cancer progression and immune evasion.
FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.
Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling.
Omics-based pharmacological evaluation reveals Yuanhu Zhitong oral liquid ameliorates arthritis by regulating PKC/ERK/NF-κB signaling pathway.
Phytochemical determination and mechanistic investigation of Polygala tenuifolia root (Yuanzhi) extract for bronchitis: UPLC-MS/MS analysis, network pharmacology and in vitro/in vivo evaluation.
iPSC-derived NK cells with site-specific integration of CAR19 and IL24 at the multi-copy rDNA locus enhanced antitumor activity and proliferation.
Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome.
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.
Paeonol interferes with lupus nephritis by regulating M1/M2 polarization of macrophages.
D-alanine suppressed osteoclastogenesis derived from bone marrow macrophages and downregulated ERK/p38 signalling pathways.
Systemic loss of CD36 aggravates NAFLD-related HCC through MEK1/2-ERK1/2 signaling pathway.
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis.
CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma.
Naringin attenuates Actinobacillus pleuropneumoniae-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway.
GPS2 ameliorates cigarette smoking-induced pulmonary vascular remodeling by modulating the ras-Raf-ERK axis.
Classical prescription Floris Sophorae Powder treat colorectal cancer by regulating KRAS/MEK-ERK signaling pathway.
Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota-Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice.
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Crocin Inhibits Orbital Fibroblasts Fibrosis in Thyroid-Associated Ophthalmopathy.
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Mucous cell histopathology and label-free quantitative proteomic analysis of skin mucus in fat greenling (Hexagrammos otakii) infected with Vibrio harveyi.
Therapeutic potential of SHCBP1 inhibitor AZD5582 in pancreatic cancer treatment.
Caffeic acid-grafted chitooligosaccharides downregulate MAPK and NF-kB in RAW264.7 cells.
CETSA-MS-based target profiling of anti-aging natural compound quercetin.
Protective Effects of Carbonated Chitosan Montmorillonite on Vomitoxin-Induced Intestinal Inflammation.
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.
N6-methyladenosine-modified CircPSMA7 enhances bladder cancer malignancy through the miR-128-3p/MAPK1 axis.
Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis.
Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice.
Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.
Deciphering the antidepressant effects of Rosa damascena essential oil mediated through the serotonergic synapse signaling pathway.
Chondroitin sulfate/silk fibroin hydrogel incorporating graphene oxide quantum dots with photothermal-effect promotes type H vessel-related wound healing.
d-mannose targets PD-1 to lysosomal degradation and enhances T cell-mediated anti-tumor immunity.
Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.
SHED-exos promote saliva secretion by suppressing p-ERK1/2-mediated apoptosis in glandular cells.
LncRNA AC100826.1 regulated PLCB1 to promote progression in non-small cell lung cancer.
GRP78 Downregulation in Keratinocytes Promotes Skin Inflammation through the Recruitment and Activation of CCR6(+) IL-17A-Producing γδ T Cells.
THSG alleviates cerebral ischemia/reperfusion injury via the GluN2B-CaMKII-ERK1/2 pathway.
Integration analysis of cell division cycle-associated family genes revealed potential mechanisms of gliomagenesis and constructed an artificial intelligence-driven prognostic signature.
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
Narirutin mitigates dextrose sodium sulfate-induced colitis in mice by modulating intestinal flora.
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas.
Maternal high fat diet programs spatial learning and central leptin signaling in mouse offspring in a sex-specific manner.
Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.
Amplifying T cell-mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti-PD1.
Inulin alters gut microbiota to alleviate post-stroke depressive-like behavior associated with the IGF-1-mediated MAPK signaling pathway.
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca(2+) antagonism and maintaining mitochondrial function.
Polysaccharide from Artocarpus heterophyllus Lam. (Jackfruit) Pulp Ameliorates Dextran Sodium Sulfate-Induced Enteritis in Rats.
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Investigation of Tongxie-Yaofang formula in treating ulcerative colitis based on network pharmacology via regulating MAPK/AKT signaling pathway.
Bioinformatics and experimental studies jointly reveal that Sacubitril Valsartan improves myocardial oxidative stress and inflammation by regulating the MAPK signaling pathway to treat chemotherapy related cardiotoxicity.
Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway.
Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK/NF-κB pathways.
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice.
Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts.
Bufei Yishen formula protects the airway epithelial barrier and ameliorates COPD by enhancing autophagy through the Sirt1/AMPK/Foxo3 signaling pathway.
BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response.
An Inulin-Type Fructan CP-A from Codonopsis pilosula Alleviated 5-Fluorouracil-Induced Intestinal Mucositis via the ERK/MLCK/MLC2 Pathway and Regulation of Gut Microbiota.
JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway.
Puerarin Ameliorated PCOS through Preventing Mitochondrial Dysfunction Dependent on the Maintenance of Intracellular Calcium Homeostasis.
Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer.
Sasanquasaponin from Camellia oleifera Abel Exerts an Anti-Inflammatory Effect in RAW 264.7 Cells via Inhibition of the NF-κB/MAPK Signaling Pathways.
Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells.
CP41, a novel curcumin analogue, induces apoptosis in endometrial cancer cells by activating the H3F3A/ proteasome-MAPK signaling pathway and enhancing oxidative stress.
Peptidylprolyl isomerase D circular RNA sensitizes breast cancer to trastuzumab through remodeling HER2 N4-acetylcytidine modification.
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.
Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model.
TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.
RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition.
Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species.
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis.
A TGF-β signaling-related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response.
Discovery of a Pimaradiene that Decreases Viability of MDA-MB-468 Cells Through Inhibition of EGFR Signaling Pathway.
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
The prenatal use of agmatine prevents social behavior deficits in VPA-exposed mice by activating the ERK/CREB/BDNF signaling pathway.
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation.
Oxidative stress-induced temporal activation of ERK1/2 phosphorylates coreceptor of Wnt/β-catenin for myofibroblast formation in human lens epithelial cells.
BIBF1120 Protects against Diabetic Retinopathy through Neovascularization-Related Molecules and the MAPK Signaling Pathway.
Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways.
Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and Promotes Apoptosis and Autophagy of Gastric Cancer Cells.
Suppression of migration and invasion by taraxerol in the triple-negative breast cancer cell line MDA-MB-231 via the ERK/Slug axis.
Establishment of Risk Model and Analysis of Immunoinfiltration Based on Mitophagy-Related Associated Genes in Atrial Fibrillation.
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.
Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt's lymphoma cells by inhibiting AKT and ERK.
Exploration of the mechanism of aloin ameliorates of combined allergic rhinitis and asthma syndrome based on network pharmacology and experimental validation.
Supramolecular nanofibers co-loaded with dabrafenib and doxorubicin for targeted and synergistic therapy of differentiated thyroid carcinoma.
Copine 7 promotes colorectal cancer proliferation through PKM2 interaction and MAPK signaling pathway.
The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin.
Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance.
A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement.
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization.
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Yueju volatile oil plays an integral role in the antidepressant effect by up-regulating ERK/AKT-mediated GLT-1 expression to clear glutamate.
Oridonin inhibits the occurrence and development of colorectal cancer by reversing the Warburg effect via reducing PKM2 dimer formation and preventing its entry into the nucleus.
Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.
Long-Term Exposure to Microcystin-LR Induces Gastric Toxicity by Activating the Mitogen-Activated Protein Kinase Signaling Pathway.
Inhibition of FNDC1 suppresses gastric cancer progression by interfering with Gβγ-VEGFR2 complex formation.
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Formin-related protein 1 facilitates proliferation and aggressive phenotype of clear cell renal cell carcinoma through MAPK/MMP2 pathway.
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Identification of a receptor tyrosine kinase inhibitor CP-724714 inhibits SADS-CoV related swine diarrhea coronaviruses infection in vitro.
HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway.
Lens epithelial cell-derived exosome inhibits angiogenesis in ocular pathological neovascularization through its delivery of miR-146a-5p.
Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus.
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Transcriptome Analysis Revealed Potential Genes of Skeletal Muscle Thermogenesis in Mashen Pigs and Large White Pigs under Cold Stress.
FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke.
Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation.
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Multi-omics reveals aging-related pathway in natural aging mouse liver.
Ketamine counteracts sevoflurane-induced depressive-like behavior and synaptic plasticity impairments through the adenosine A2A receptor/ERK pathway in rats.
Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation.
The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection.
Study on the Alleviating Effect and Potential Mechanism of Ethanolic Extract of Limonium aureum (L.) Hill. on Lipopolysaccharide-Induced Inflammatory Responses in Macrophages.
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma.
Methionine sulfoxide suppresses adipogenic differentiation by regulating the mitogen-activated protein kinase signaling pathway.
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.
The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis.
Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation.
Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway.
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway.
Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation.
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways.
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.
Chitosan targets PI3K/Akt/FoxO3a axis to up-regulate FAM172A and suppress MAPK/ERK pathway to exert anti-tumor effect in osteosarcoma.
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
Exercise-induced endothelial Mecp2 lactylation suppresses atherosclerosis via the Ereg/MAPK signalling pathway.
Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex.
The Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple.
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway.
Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production.
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Endothelial progenitor cell-derived exosomes inhibit pulmonary artery smooth muscle cell in vitro proliferation and resistance to apoptosis by modulating the Mitofusin-2 and Ras-Raf-ERK1/2 signaling pathway.
Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia.
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice.
A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer.
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Elevated retinal fibrosis in experimental myopia is involved in the activation of the PI3K/AKT/ERK signaling pathway.
Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.
Resveratrol May Reduce the Degree of Periodontitis by Regulating ERK Pathway in Gingival-Derived MSCs.
TRPC6 promotes daunorubicin-induced mitochondrial fission and cell death in rat cardiomyocytes with the involvement of ERK1/2-DRP1 activation.
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.
HIV Tat-Conjugated Histone H3 Peptides Induce Tumor Cell Death Via Cellular Stress Responses.
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation.
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.
Deficit of PKHD1L1 in the dentate gyrus increases seizure susceptibility in mice.
Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis.
LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer.
CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.
Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.
Elevated PGT promotes proliferation and inhibits cell apoptosis in preeclampsia by Erk signaling pathway.
Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma.
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity.
Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia.
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Gelatin methacryloyl (GelMA) loaded with concentrated hypoxic pretreated adipose-derived mesenchymal stem cells(ADSCs) conditioned medium promotes wound healing and vascular regeneration in aged skin.
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Wen-Shen-Tong-Luo-Zhi-Tong Decoction regulates bone-fat balance in osteoporosis by adipocyte-derived exosomes.
Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.
Mechanisms of dihydromyricetin against hepatocellular carcinoma elucidated by network pharmacology combined with experimental validation.
Sema3A inactivates the ERK/JNK signalling pathways to alleviate inflammation and oxidative stress in lipopolysaccharide-stimulated rat endothelial cells and lung tissues.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Herbal compound cepharanthine attenuates inflammatory arthritis by blocking macrophage M1 polarization.
Liensinine improves AngII-induced vascular remodeling via MAPK/TGF-β1/Smad2/3 signaling.
The ethanol extract of Scutellaria baicalensis Georgi attenuates complete Freund's adjuvant (CFA)-induced inflammatory pain by suppression of P2X3 receptor.
Modification of osimertinib to discover new potent EGFR(C797S)-TK inhibitors.
Discovery of highly potent and selective KRAS(G12C) degraders by VHL-recruiting PROTACs for the treatment of tumors with KRAS(G12C)-Mutation.
Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE(-/-) Mice.
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation.
GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.
Ultrasound-targeted microbubble destruction promotes PDGF-primed bone mesenchymal stem cell transplantation for myocardial protection in acute Myocardial Infarction in rats.
Banxia Xiexin decoction ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis via inhibiting serine-threonine protein kinase (Akt)/mitogen-activated protein kinase (MAPK) signaling pathway.
Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo.
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
The Inhibitory Effect of RADKPS on Pyroptosis of Nucleus Pulposus-Derived Mesenchymal Stem Cells.
ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy.
PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer.
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling.
Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell.
Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling.
Exosomes incorporated with black phosphorus quantum dots attenuate retinal angiogenesis via disrupting glucose metabolism.
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
Promoted Skin Wound Healing by Tail-Amputated Eisenia foetida Proteins via the Ras/Raf/MEK/ERK Signaling Pathway.
SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway.
Subchronic Microcystin-LR Aggravates Colorectal Inflammatory Response and Barrier Disruption via Raf/ERK Signaling Pathway in Obese Mice.
CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study.
7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells.
Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction.
Sufentanil Alleviates Sepsis-Induced Myocardial Injury and Stress Response in Rats through the ERK/GSK-3β Signaling Axis.
Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain.
Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors.
Systematic Pharmacology-Based Strategy to Explore the Mechanism of Bufei Huoxue Capsule in the Treatment of Chronic Obstructive Pulmonary Disease.
Smart thermosensitive poloxamer hydrogels loaded with Nr-CWs for the treatment of diabetic wounds.
METTL3 Facilitates Tumor Progression by COL12A1/MAPK Signaling Pathway in Esophageal Squamous Cell Carcinoma.
Bu-Gu-Sheng-Sui decoction promotes osteogenesis via activating the ERK/Smad signaling pathways.
Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.
Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro.
Dysfunction of CCR1(+) decidual macrophages is a potential risk factor in the occurrence of unexplained recurrent pregnancy loss.
High-Metastatic Melanoma Cells Promote the Metastatic Capability of Low-Metastatic Melanoma Cells via Exosomal Transfer of miR-411-5p.
The Specifically Androgen-Regulated Gene (SARG) Promotes Papillary Thyroid Carcinoma (PTC) Lymphatic Metastasis Through Vascular Endothelial Growth Factor C (VEGF-C) and VEGF Receptor 3 (VEGFR-3) Axis.
Poloxamer 407 and Hyaluronic Acid Thermosensitive Hydrogel-Encapsulated Ginsenoside Rg3 to Promote Skin Wound Healing.
HIV-1 Tat Protein-Mediated Inflammatory Response Inhibits the Erythroid Hematopoietic Support Function of Bone Marrow Mesenchymal Stem Cells.
Traditional herbal formula Jiao-tai-wan improves chronic restrain stress-induced depression-like behaviors in mice.
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia.
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Combination of RSK inhibitor LJH-685 and FLT3 inhibitor FF-10101 promoted apoptosis and proliferation inhibition of AML cell lines.
Cpd-0225 attenuates renal fibrosis via inhibiting ALK5.
Identification of four STAT3 isoforms and functional investigation of IL-6/JAK2/STAT3 pathway in blunt snout bream (Megalobrama amblycephala).
Triclocarban evoked neutrophil extracellular trap formation in common carp (Cyprinus carpio L.) by modulating SIRT3-mediated ROS crosstalk with ERK1/2/p38 signaling.
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Exosomal DNAJB11 promotes the development of pancreatic cancer by modulating the EGFR/MAPK pathway.
ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8.
Autophagy triggered by the ROS/ERK signaling pathway protects mouse embryonic palatal cells from apoptosis induced by nicotine.
Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa.
Non-Muscle MLCK Contributes to Endothelial Cell Hyper-Proliferation through the ERK Pathway as a Mechanism for Vascular Remodeling in Pulmonary Hypertension.
Orally Administered Ginkgolide C Attenuates DSS-Induced Colitis by Maintaining Gut Barrier Integrity, Inhibiting Inflammatory Responses, and Regulating Intestinal Flora.
Effects of Camk2b Overexpression and Underexpression on the Proteome of Rat Hippocampal Neurons.
Effects of thymoquinone against angiotensin II‑induced cardiac damage in apolipoprotein E‑deficient mice.
Optimization of the saffron compound essence formula and its effect on preventing skin photoaging.
Immunomodulatory activity of aqueous extract from Crassostrea sikamea in the splenocytes of Sprague-Dawley rats.
Downregulation of lncRNA SNHG16 inhibits vascular smooth muscle cell proliferation and migration in cerebral atherosclerosis by targeting the miR-30c-5p/SDC2 axis.
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
Blockade of mIL-6R alleviated lipopolysaccharide-induced systemic inflammatory response syndrome by suppressing NF-κB-mediated Ccl2 expression and inflammasome activation.
A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells.
MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway.
Near-Infrared Light-Responsive Nanoinhibitors for Tumor Suppression through Targeting and Regulating Anion Channels.
Effect of Qingyangshen glycosides on social defeat mice model.
Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway.
Investigation of cell cytotoxic activity and molecular mechanism of 5β,19-epoxycucurbita-6,23(E)-diene-3β,19(R),25-triol isolated from Momordica charantia on hepatoma cells.
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites.
The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
Downregulation of IL-8 and IL-10 by the Activation of Ca(2+)-Activated K(+) Channel K(Ca)3.1 in THP-1-Derived M(2) Macrophages.
Rhodococcus equi-Derived Extracellular Vesicles Promoting Inflammatory Response in Macrophage through TLR2-NF-κB/MAPK Pathways.
Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells.
piR-121380 Is Involved in Cryo-Capacitation and Regulates Post-Thawed Boar Sperm Quality Through Phosphorylation of ERK2 via Targeting PTPN7.
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology.
Comparative Efficacy of Haizao Yuhu Decoction Composed of Different Varieties of Glycyrrhiza in Goiter Rats.
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer.
Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway.
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine.
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.
1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways.
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.
Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling.
MiR-1307-5p targeting TRAF3 upregulates the MAPK/NF-κB pathway and promotes lung adenocarcinoma proliferation.
Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression.
Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.
Resveratrol-loaded biopolymer core-shell nanoparticles: bioavailability and anti-inflammatory effects.
Inhibiting PKCβ2 protects HK-2 cells against meglumine diatrizoate and AGEs-induced apoptosis and autophagy.
Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts.
Hfm1 participates in Golgi-associated spindle assembly and division in mouse oocyte meiosis.
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice.
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
MiR-96-5p promotes breast cancer migration by activating MEK/ERK signaling.
PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation.
Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling.
Soluble epoxide hydrolase inhibition alleviated cognitive impairments via NRG1/ErbB4 signaling after chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis in mice.
Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.
Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.
Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.
HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth.
SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway.
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca²⁺-dependent ERK signaling pathway.
Polychlorinated biphenyl quinone induces endothelial barrier dysregulation by setting the cross talk between VE-cadherin, focal adhesion, and MAPK signaling.
Tenascin-C induces resistance to apoptosis in pancreatic cancer cell through activation of ERK/NF-κB pathway.
Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions.
13-acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression.
MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway.
Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway.
Sun YL, Zhao PP, Zhu CB, Li XM, Yuan B
Combinatorial chemistry & high throughput screening 2024;27(7):969-983
Combinatorial chemistry & high throughput screening 2024;27(7):969-983
miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK.
Dai Q, Shi R, Zhang G, Wang Y, Ye L, Peng L, Guo S, He J, Yang H, Jiang Y
Experimental biology and medicine (Maywood, N.J.) 2024;249:10111
Experimental biology and medicine (Maywood, N.J.) 2024;249:10111
Dual role of CD73 as a signaling molecule and adenosine-generating enzyme in colorectal cancer progression and immune evasion.
Lian W, Jiang D, Lin W, Jiang M, Zhang Y, Wang H, Zhao L
International journal of biological sciences 2024;20(1):137-151
International journal of biological sciences 2024;20(1):137-151
FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.
Zhao M, Rong R, Zhang C, Yang H, Han X, Fan Z, Zheng Y, Zhang J
Current stem cell research & therapy 2024;19(3):417-425
Current stem cell research & therapy 2024;19(3):417-425
Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling.
Liu J, Wang S, Zhang C, Wei Z, Han D, Song Y, Song X, Chao F, Wu Z, Xu G, Chen G
American journal of cancer research 2024;14(2):490-506
American journal of cancer research 2024;14(2):490-506
Omics-based pharmacological evaluation reveals Yuanhu Zhitong oral liquid ameliorates arthritis by regulating PKC/ERK/NF-κB signaling pathway.
Zhang K, Yin Z, Chen F, Cao Z, Guan J, Chen C, Wang Y, Fan G
Journal of ethnopharmacology 2024 Sep 15;331:118289
Journal of ethnopharmacology 2024 Sep 15;331:118289
Phytochemical determination and mechanistic investigation of Polygala tenuifolia root (Yuanzhi) extract for bronchitis: UPLC-MS/MS analysis, network pharmacology and in vitro/in vivo evaluation.
Chen T, Zhou X, Zhu M, Chen X, Chang D, Lin Y, Xu W, Zheng Y, Li S, Song J, Huang M
Journal of ethnopharmacology 2024 Oct 28;333:118418
Journal of ethnopharmacology 2024 Oct 28;333:118418
iPSC-derived NK cells with site-specific integration of CAR19 and IL24 at the multi-copy rDNA locus enhanced antitumor activity and proliferation.
Zhang Y, Shi Q, Wang P, Huang C, Tang S, Zhou M, Hu Q, Wu L, Liang D
MedComm 2024 May;5(5):e553
MedComm 2024 May;5(5):e553
Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome.
Guo X, Cao Y, He Q, Chen L, Wang Q, Zhang J, Lv W, Zhang B, Zhou X
Human cell 2024 May;37(3):689-703
Human cell 2024 May;37(3):689-703
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.
Ren D, Li W, Zeng R, Liu X, Liang H, Xiong W, Yang C, Jin X
Cell death and differentiation 2024 May;31(5):592-604
Cell death and differentiation 2024 May;31(5):592-604
Paeonol interferes with lupus nephritis by regulating M1/M2 polarization of macrophages.
Niu Y, Jin Y, Hao Y, Liang W, Tang F, Qin Z, Liang T, Shi L
Molecular immunology 2024 May;169:66-77
Molecular immunology 2024 May;169:66-77
D-alanine suppressed osteoclastogenesis derived from bone marrow macrophages and downregulated ERK/p38 signalling pathways.
Chang X, Deng J, Zhou F, Geng Z, Li X, Wang S
Archives of oral biology 2024 May;161:105912
Archives of oral biology 2024 May;161:105912
Systemic loss of CD36 aggravates NAFLD-related HCC through MEK1/2-ERK1/2 signaling pathway.
Zheng E, Chen Q, Xiao A, Luo X, Lu Q, Tian C, Liu H, Zhao J, Wei L, Yang P, Chen Y
Biochemical and biophysical research communications 2024 May 7;707:149781
Biochemical and biophysical research communications 2024 May 7;707:149781
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, Li YT, Wang TC, Kan TY, Wang J, Tao HR
Military Medical Research 2024 May 6;11(1):28
Military Medical Research 2024 May 6;11(1):28
Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis.
Lu C, Deng S, Liu Y, Yang S, Qin D, Zhang L, Wang RR, Zhang Y
International immunopharmacology 2024 May 30;133:112038
International immunopharmacology 2024 May 30;133:112038
CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma.
Simbulan-Rosenthal CM, Islam N, Haribabu Y, Alobaidi R, Shalamzari A, Graham G, Kuo LW, Sykora P, Rosenthal DS
Cells 2024 May 2;13(9)
Cells 2024 May 2;13(9)
Naringin attenuates Actinobacillus pleuropneumoniae-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway.
Huang QL, Huang LN, Zhao GY, Liu C, Pan XY, Li ZR, Jing XH, Qiu ZY, Xin RH
BMC veterinary research 2024 May 17;20(1):204
BMC veterinary research 2024 May 17;20(1):204
GPS2 ameliorates cigarette smoking-induced pulmonary vascular remodeling by modulating the ras-Raf-ERK axis.
Hu T, Mu C, Li Y, Hao W, Yu X, Wang Y, Han W, Li Q
Respiratory research 2024 May 16;25(1):210
Respiratory research 2024 May 16;25(1):210
Classical prescription Floris Sophorae Powder treat colorectal cancer by regulating KRAS/MEK-ERK signaling pathway.
Han LY, Yu H, Wang S, Bao YR, Li TJ, Zheng Y, Luo X, Jia MN, Zhang Q, Meng XS
Journal of ethnopharmacology 2024 May 10;325:117805
Journal of ethnopharmacology 2024 May 10;325:117805
Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota-Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice.
Zhong Z, Zhang Y, Wei Y, Li X, Ren L, Li Y, Zhang X, Chen C, Yin X, Liu R, Wang Q
Journal of agricultural and food chemistry 2024 May 1;72(17):9755-9767
Journal of agricultural and food chemistry 2024 May 1;72(17):9755-9767
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645
Experimental & molecular medicine 2024 Mar;56(3):630-645
Crocin Inhibits Orbital Fibroblasts Fibrosis in Thyroid-Associated Ophthalmopathy.
Xu S, Mao H
Current eye research 2024 Mar;49(3):330-337
Current eye research 2024 Mar;49(3):330-337
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Miao J, Tu Y, Jiang J, Ren R, Wu Q, Liang H, Wang T, Lin B, Wu J, Pan Y, Wang X, Jin H
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
Mucous cell histopathology and label-free quantitative proteomic analysis of skin mucus in fat greenling (Hexagrammos otakii) infected with Vibrio harveyi.
Wei X, Shi Y, Wang S, Liu H, Zhang Z, Yu L, Hua W, Cui D, Chen Y, Li X, Wang W
Fish & shellfish immunology 2024 Mar;146:109398
Fish & shellfish immunology 2024 Mar;146:109398
Therapeutic potential of SHCBP1 inhibitor AZD5582 in pancreatic cancer treatment.
Ma Z, Gu Q, Dai Y, Wang Q, Shi W, Jiao Z
Cancer science 2024 Mar;115(3):820-835
Cancer science 2024 Mar;115(3):820-835
Caffeic acid-grafted chitooligosaccharides downregulate MAPK and NF-kB in RAW264.7 cells.
Bui VH, Vo HN, Kim SK, Ngo DN
Chemical biology & drug design 2024 Mar;103(3):e14496
Chemical biology & drug design 2024 Mar;103(3):e14496
CETSA-MS-based target profiling of anti-aging natural compound quercetin.
Bai L, Deng Z, Xu M, Zhang Z, Guo G, Xue X, Wang S, Yang J, Xia Z
European journal of medicinal chemistry 2024 Mar 5;267:116203
European journal of medicinal chemistry 2024 Mar 5;267:116203
Protective Effects of Carbonated Chitosan Montmorillonite on Vomitoxin-Induced Intestinal Inflammation.
Tang R, Ju X, Niu X, Liu X, Li Y, Yu Z, Ma X, Gao Y, Li Y, Xie H, Zhou Q, Yong Y
Polymers 2024 Mar 5;16(5)
Polymers 2024 Mar 5;16(5)
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.
Liu ZD, Shi YH, Xu QC, Zhao GY, Zhu YQ, Li FX, Ma MJ, Ye JY, Huang XT, Wang XY, Xu X, Wang JQ, Zhao W, Yin XY
Cancer letters 2024 Mar 31;585:216640
Cancer letters 2024 Mar 31;585:216640
N6-methyladenosine-modified CircPSMA7 enhances bladder cancer malignancy through the miR-128-3p/MAPK1 axis.
Yi J, Ma X, Ying Y, Liu Z, Tang Y, Shu X, Sun J, Wu Y, Lu D, Wang X, Luo J, Liu B, Zheng X, Lin Y, Li J, Xie L
Cancer letters 2024 Mar 31;585:216613
Cancer letters 2024 Mar 31;585:216613
Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis.
Zhou L, Chen S, Wei Y, Sun Y, Yang Y, Lin B, Li Y, Wang C
European journal of pharmacology 2024 Mar 15;967:176365
European journal of pharmacology 2024 Mar 15;967:176365
Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice.
Zhou Y, Du Z, Wu Q, Guo M, Chen Z, Sun C, Li X, Zou Y, Zheng Z, Chen P, Cho WJ, Cho YC, Chattipakorn N, Wang Y, Liang G, Tang Q
European journal of medicinal chemistry 2024 Mar 15;268:116252
European journal of medicinal chemistry 2024 Mar 15;268:116252
Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.
Ren LK, Lu RS, Fei XB, Chen SJ, Liu P, Zhu CH, Wang X, Pan YZ
Journal of cancer research and clinical oncology 2024 Mar 14;150(3):127
Journal of cancer research and clinical oncology 2024 Mar 14;150(3):127
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
Dong P, Zhou L, Wang X, Xue L, Du Y, Cui R
European journal of medical research 2024 Mar 1;29(1):149
European journal of medical research 2024 Mar 1;29(1):149
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.
Ci M, Zhao G, Li C, Liu R, Hu X, Pan J, Shen Y, Zhang G, Li Y, Zhang L, Liang P, Cui H
Cell death & disease 2024 Mar 1;15(3):179
Cell death & disease 2024 Mar 1;15(3):179
Deciphering the antidepressant effects of Rosa damascena essential oil mediated through the serotonergic synapse signaling pathway.
Xia N, Wang J, Guo Q, Duan J, Wang X, Zhou P, Li J, Tang T, Li T, Li H, Wu Z, Yang M, Sun J, Guo D, Chang X, Zhang X
Journal of ethnopharmacology 2024 Jun 28;328:118007
Journal of ethnopharmacology 2024 Jun 28;328:118007
Chondroitin sulfate/silk fibroin hydrogel incorporating graphene oxide quantum dots with photothermal-effect promotes type H vessel-related wound healing.
Deng T, Lu W, Zhao X, Wang H, Zheng Y, Zheng A, Shen Z
Carbohydrate polymers 2024 Jun 15;334:121972
Carbohydrate polymers 2024 Jun 15;334:121972
d-mannose targets PD-1 to lysosomal degradation and enhances T cell-mediated anti-tumor immunity.
Dong W, Lin M, Zhang R, Sun X, Li H, Liu T, Xu Y, Lv L
Cancer letters 2024 Jun 1;591:216883
Cancer letters 2024 Jun 1;591:216883
Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.
Wang CY, Li MY, Li SY, Wei XG, Dong NX, Liu ST, Yuan ZW, Li B, Pierro A, Tang XB, Bai YZ
Cell proliferation 2024 Jul;57(7):e13618
Cell proliferation 2024 Jul;57(7):e13618
SHED-exos promote saliva secretion by suppressing p-ERK1/2-mediated apoptosis in glandular cells.
Chu WX, Ding C, Du ZH, Wei P, Wang YX, Ge XJ, Yu GY
Oral diseases 2024 Jul;30(5):3066-3080
Oral diseases 2024 Jul;30(5):3066-3080
LncRNA AC100826.1 regulated PLCB1 to promote progression in non-small cell lung cancer.
Dai S, Wang Q, Lyu Y, Chen Z, Liu X, Zhao G, Zhang H
Thoracic cancer 2024 Jul;15(19):1477-1489
Thoracic cancer 2024 Jul;15(19):1477-1489
GRP78 Downregulation in Keratinocytes Promotes Skin Inflammation through the Recruitment and Activation of CCR6(+) IL-17A-Producing γδ T Cells.
Zhao L, Li J, Jiang B, Yang J, Lan J, Li D, Wen J, Xia Y, Nie W, Wang Z, Lv Y, Zeng F, Li Y, Shen G, Lei P, Tao J
The Journal of investigative dermatology 2024 Jul;144(7):1557-1567.e11
The Journal of investigative dermatology 2024 Jul;144(7):1557-1567.e11
THSG alleviates cerebral ischemia/reperfusion injury via the GluN2B-CaMKII-ERK1/2 pathway.
Liu T, Shi J, Wu D, Li D, Wang Y, Liu J, Meng P, Hu L, Fu C, Mei Z, Ge J, Zhang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155595
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155595
Integration analysis of cell division cycle-associated family genes revealed potential mechanisms of gliomagenesis and constructed an artificial intelligence-driven prognostic signature.
Yu K, Tian Q, Feng S, Zhang Y, Cheng Z, Li M, Zhu H, He J, Li M, Xiong X
Cellular signalling 2024 Jul;119:111168
Cellular signalling 2024 Jul;119:111168
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
Yang Y, Zhao C, Yang Z, Du C, Chang Z, Wen X, Zhang X, Liu Y, Hu L, Gao Z
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Narirutin mitigates dextrose sodium sulfate-induced colitis in mice by modulating intestinal flora.
Xu D, Liu D, Jiang N, Xie Y, He D, Cheng J, Liu J, Fu S, Hu G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155730
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155730
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
Li Y, Deng X, Hu Q, Chen Y, Zhang W, Qin X, Wei F, Lu X, Ma X, Zeng J, Efferth T
Journal of ethnopharmacology 2024 Jul 15;329:118107
Journal of ethnopharmacology 2024 Jul 15;329:118107
GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas.
Ren J, Cui Z, Jiang C, Wang L, Guan Y, Ren Y, Zhang S, Tu T, Yu J, Li Y, Duan W, Guan J, Wang K, Zhang H, Xing D, Kahn ML, Zhang H, Hong T
American journal of human genetics 2024 Jul 11;111(7):1370-1382
American journal of human genetics 2024 Jul 11;111(7):1370-1382
Maternal high fat diet programs spatial learning and central leptin signaling in mouse offspring in a sex-specific manner.
Li Y, Yang Y, Ye B, Lin Y
Physiology & behavior 2024 Jul 1;281:114580
Physiology & behavior 2024 Jul 1;281:114580
Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.
Gao X, Long R, Qin M, Zhu W, Wei L, Dong P, Chen J, Luo J, Feng J
International journal of molecular medicine 2024 Jan;53(1)
International journal of molecular medicine 2024 Jan;53(1)
Amplifying T cell-mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti-PD1.
Gong B, Wang L, Zhang H, Wang Q, Li W
Cell biochemistry and function 2024 Jan;42(1):e3925
Cell biochemistry and function 2024 Jan;42(1):e3925
Inulin alters gut microbiota to alleviate post-stroke depressive-like behavior associated with the IGF-1-mediated MAPK signaling pathway.
Shao R, Tan X, Pan M, Huang J, Huang L, Bi B, Huang X, Wang J, Li X
Brain and behavior 2024 Jan;14(1):e3387
Brain and behavior 2024 Jan;14(1):e3387
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Cai Y, Yang H, Wan Z, Chen PY, Wang ZB, Guo JJ, Wang D, Wang F, Zhang Y
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca(2+) antagonism and maintaining mitochondrial function.
Shen G, Zhou Z, Guo Y, Li L, Zeng J, Wang J, Zhao J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117192
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117192
Polysaccharide from Artocarpus heterophyllus Lam. (Jackfruit) Pulp Ameliorates Dextran Sodium Sulfate-Induced Enteritis in Rats.
Li Y, Chen Y, Li C, Wu G, He Y, Tan L, Zhu K
International journal of molecular sciences 2024 Jan 29;25(3)
International journal of molecular sciences 2024 Jan 29;25(3)
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Huang C, Zhang Y, Xu Y, Wei S, Yang T, Wang S, Li C, Lin H, Li X, Zhao S, Zhu L, Pan W
Aging 2024 Jan 26;16(3):2362-2384
Aging 2024 Jan 26;16(3):2362-2384
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Wu W, Li G, Dong S, Huihan Chu C, Ma S, Zhang Z, Yuan S, Wu J, Guo Z, Shen Y, Wang J, Tang C
International immunopharmacology 2024 Jan 25;127:111423
International immunopharmacology 2024 Jan 25;127:111423
Investigation of Tongxie-Yaofang formula in treating ulcerative colitis based on network pharmacology via regulating MAPK/AKT signaling pathway.
Liu X, Ye M, He Y, Lai Q, Liu B, Zhang L
Aging 2024 Jan 24;16(2):1911-1924
Aging 2024 Jan 24;16(2):1911-1924
Bioinformatics and experimental studies jointly reveal that Sacubitril Valsartan improves myocardial oxidative stress and inflammation by regulating the MAPK signaling pathway to treat chemotherapy related cardiotoxicity.
Shi H, Lu H, Zheng Y, Pu P, Wei L, Hu D, Tang H, Wang L
Biochemical and biophysical research communications 2024 Jan 1;690:149244
Biochemical and biophysical research communications 2024 Jan 1;690:149244
Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway.
Wu Z, Liu Q, Cao Z, Li H, Zhou Y, Zhang P
Immunopharmacology and immunotoxicology 2024 Feb;46(1):86-92
Immunopharmacology and immunotoxicology 2024 Feb;46(1):86-92
Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK/NF-κB pathways.
Lu C, Li X, Du W, Zhang X, Li Y, Hu C, Mao Z, Zhang Y, Wang R
Bioorganic chemistry 2024 Feb;143:107054
Bioorganic chemistry 2024 Feb;143:107054
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Luan X, Lei T, Fang J, Liu X, Fu H, Li Y, Chu W, Jiang P, Tong C, Qi H, Fu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice.
He D, Gao X, Wen J, Zhang Y, Yang S, Sun X, Cui M, Li Z, Fu S, Liu J, Liu D
Food & function 2024 Feb 5;15(3):1460-1475
Food & function 2024 Feb 5;15(3):1460-1475
Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts.
Zuo J, Ma S
Heliyon 2024 Feb 29;10(4):e24985
Heliyon 2024 Feb 29;10(4):e24985
Bufei Yishen formula protects the airway epithelial barrier and ameliorates COPD by enhancing autophagy through the Sirt1/AMPK/Foxo3 signaling pathway.
Jia L, Liu X, Liu X, Guan Q, Tian Y, Li J, Zhao P
Chinese medicine 2024 Feb 28;19(1):32
Chinese medicine 2024 Feb 28;19(1):32
BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response.
Ji R, Zhang Z, Yang Z, Chen X, Yin T, Yang J
Cellular and molecular life sciences : CMLS 2024 Feb 27;81(1):101
Cellular and molecular life sciences : CMLS 2024 Feb 27;81(1):101
An Inulin-Type Fructan CP-A from Codonopsis pilosula Alleviated 5-Fluorouracil-Induced Intestinal Mucositis via the ERK/MLCK/MLC2 Pathway and Regulation of Gut Microbiota.
Zhou J, Li D, Wang J, Cheng Z, Wang C, Zhang X, Xu X, Gao J
Pharmaceuticals (Basel, Switzerland) 2024 Feb 26;17(3)
Pharmaceuticals (Basel, Switzerland) 2024 Feb 26;17(3)
JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway.
Li Z, He R, Liu J, Jin X, Jiang B, Lao Y, Yang S
BMC complementary medicine and therapies 2024 Feb 24;24(1):101
BMC complementary medicine and therapies 2024 Feb 24;24(1):101
Puerarin Ameliorated PCOS through Preventing Mitochondrial Dysfunction Dependent on the Maintenance of Intracellular Calcium Homeostasis.
Wang YS, Li BY, Xing YF, Huang JC, Chen ZS, Yue L, Zou YG, Guo B
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2963-2976
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2963-2976
Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer.
Chen Y, Qiang Y, Fan J, Zheng Q, Yan L, Fan G, Song X, Zhang N, Lv Q, Xiong J, Wang J, Cao J, Liu Y, Xiong J, Zhang W, Li F
Nature communications 2024 Feb 13;15(1):1321
Nature communications 2024 Feb 13;15(1):1321
Sasanquasaponin from Camellia oleifera Abel Exerts an Anti-Inflammatory Effect in RAW 264.7 Cells via Inhibition of the NF-κB/MAPK Signaling Pathways.
Zhao Y, Zhao N, Kollie L, Yang D, Zhang X, Zhang H, Liang Z
International journal of molecular sciences 2024 Feb 10;25(4)
International journal of molecular sciences 2024 Feb 10;25(4)
Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells.
Xia L, Liu JY, Yang MY, Zhang XH, Jiang Y, Yin QQ, Luo CH, Liu HC, Kang ZJ, Zhang CT, Gao BB, Zhou AW, Cai HY, Waller EK, Yan JS, Lu Y
Cancer research 2024 Feb 1;84(3):479-492
Cancer research 2024 Feb 1;84(3):479-492
CP41, a novel curcumin analogue, induces apoptosis in endometrial cancer cells by activating the H3F3A/ proteasome-MAPK signaling pathway and enhancing oxidative stress.
Zhang MJ, Shi M, Yu Y, Wang H, Ou R, Ge RS
Life sciences 2024 Feb 1;338:122406
Life sciences 2024 Feb 1;338:122406
Peptidylprolyl isomerase D circular RNA sensitizes breast cancer to trastuzumab through remodeling HER2 N4-acetylcytidine modification.
Wang S, Li Q, Wang Y, Li X, Feng X, Wei Y, Wang J, Zhou X
Journal of applied genetics 2024 Dec;65(4):797-807
Journal of applied genetics 2024 Dec;65(4):797-807
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.
Gao S, Cheng Q, Hu Y, Fan X, Liang C, Niu C, Kang Q, Wei T
Molecular and cellular biochemistry 2024 Dec;479(12):3393-3404
Molecular and cellular biochemistry 2024 Dec;479(12):3393-3404
Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model.
Xie Y, Xu H, Gu Z
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2024 Dec;44(1):2337691
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2024 Dec;44(1):2337691
TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.
Gao Y, Hou J, Fei X, Ren L, Lu R, Liu P, Liu S, Zhu C, Wang X, Pan Y
Cellular signalling 2024 Aug;120:111227
Cellular signalling 2024 Aug;120:111227
RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition.
Dong W, Li X, Cheng L, Yang J, Zhao Z, Qiang X, Li P, Wu J, Guo L
Archives of biochemistry and biophysics 2024 Apr;754:109896
Archives of biochemistry and biophysics 2024 Apr;754:109896
Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species.
Zhao H, Zhao H, Li M, Tang Y, Xiao X, Cai Y, He F, Huang H, Zhang Y, Li J
Redox biology 2024 Apr;70:103055
Redox biology 2024 Apr;70:103055
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis.
Zhao C, Yu Y, Yin G, Xu C, Wang J, Wang L, Zhao G, Ni S, Zhang H, Zhou B, Wang Y
Inflammopharmacology 2024 Apr;32(2):1277-1294
Inflammopharmacology 2024 Apr;32(2):1277-1294
A TGF-β signaling-related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response.
Duan WW, Yang LT, Liu J, Dai ZY, Wang ZY, Zhang H, Zhang X, Liang XS, Luo P, Zhang J, Liu ZQ, Zhang N, Mo HY, Qu CR, Xia ZW, Cheng Q
CNS neuroscience & therapeutics 2024 Apr;30(4):e14489
CNS neuroscience & therapeutics 2024 Apr;30(4):e14489
Discovery of a Pimaradiene that Decreases Viability of MDA-MB-468 Cells Through Inhibition of EGFR Signaling Pathway.
Wang N, Qin L, Liu Z, Cao J, Huang J, Ma L, Huang G
Chemistry & biodiversity 2024 Apr;21(4):e202400288
Chemistry & biodiversity 2024 Apr;21(4):e202400288
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
Chen L, Wang J, Ren Y, Ma Y, Liu J, Jiang H, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
The prenatal use of agmatine prevents social behavior deficits in VPA-exposed mice by activating the ERK/CREB/BDNF signaling pathway.
Chen S, Xu Q, Zhao L, Zhang M, Xu H
Birth defects research 2024 Apr;116(4):e2336
Birth defects research 2024 Apr;116(4):e2336
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Wang Z, Dong Z, Li Y, Jiao X, Liu Y, Chang H, Gan Y
Biomedicines 2024 Apr 18;12(4)
Biomedicines 2024 Apr 18;12(4)
FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation.
Yuan Z, Yang L, Li Y, Li X, Peng C, Pan J, Cai D
BMC musculoskeletal disorders 2024 Apr 12;25(1):282
BMC musculoskeletal disorders 2024 Apr 12;25(1):282
Oxidative stress-induced temporal activation of ERK1/2 phosphorylates coreceptor of Wnt/β-catenin for myofibroblast formation in human lens epithelial cells.
Guo Z, Ma X, Chen X, Zhang RX, Yan H
Molecular vision 2023;29:206-216
Molecular vision 2023;29:206-216
BIBF1120 Protects against Diabetic Retinopathy through Neovascularization-Related Molecules and the MAPK Signaling Pathway.
Cao X, Li T, Tian Y, Tian Y, Gao C, Zhang D, Song Y
Journal of ophthalmology 2023;2023:7355039
Journal of ophthalmology 2023;2023:7355039
Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways.
Chen X, Lin L, Wu Q, Li S, Wang H, Sun Y
Mediators of inflammation 2023;2023:5679966
Mediators of inflammation 2023;2023:5679966
Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and Promotes Apoptosis and Autophagy of Gastric Cancer Cells.
Zhu L, Yao Z, Luo Q, Liu Y, Zhao W, Shao C, Shao S, Cui F
International journal of medical sciences 2023;20(8):1038-1045
International journal of medical sciences 2023;20(8):1038-1045
Suppression of migration and invasion by taraxerol in the triple-negative breast cancer cell line MDA-MB-231 via the ERK/Slug axis.
Xia YT, Zhang YQ, Chen L, Min L, Huang D, Zhang Y, Li C, Li ZH
PloS one 2023;18(9):e0291693
PloS one 2023;18(9):e0291693
Establishment of Risk Model and Analysis of Immunoinfiltration Based on Mitophagy-Related Associated Genes in Atrial Fibrillation.
Sang W, Wang L, Yan X, Sun H, Han Y, Wang F, Tang B, Li Y
Journal of inflammation research 2023;16:2561-2583
Journal of inflammation research 2023;16:2561-2583
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.
Yang HW, Lan Y, Li A, Wu H, Song ZW, Wan AL, Wang Y, Li SB, Ji S, Wang ZC, Wu XY, Lan T
Frontiers in pharmacology 2023;14:1288883
Frontiers in pharmacology 2023;14:1288883
Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt's lymphoma cells by inhibiting AKT and ERK.
Yuan-Ce L, Qi Z, Hong-Yang Z, Yan-Wen W, Yu-Mei S, Bi-Juan Y, Jun-Lin Y
Frontiers in pharmacology 2023;14:1218467
Frontiers in pharmacology 2023;14:1218467
Exploration of the mechanism of aloin ameliorates of combined allergic rhinitis and asthma syndrome based on network pharmacology and experimental validation.
Feng Y, Qiao H, Liu H, Wang J, Tang H
Frontiers in pharmacology 2023;14:1218030
Frontiers in pharmacology 2023;14:1218030
Supramolecular nanofibers co-loaded with dabrafenib and doxorubicin for targeted and synergistic therapy of differentiated thyroid carcinoma.
Chen P, Cai X, Mu G, Duan Y, Jing C, Yang Z, Yang C, Wang X
Theranostics 2023;13(7):2140-2153
Theranostics 2023;13(7):2140-2153
Copine 7 promotes colorectal cancer proliferation through PKM2 interaction and MAPK signaling pathway.
Yu T, Huang C, Lai C, He Q, Yuan W, Chen Z
Frontiers in oncology 2023;13:1166444
Frontiers in oncology 2023;13:1166444
The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin.
Zhou Y, Bai R, Huang Y, Li W, Chen J, Cheng Z, Wu X, Diao Y
Frontiers in bioengineering and biotechnology 2023;11:1229387
Frontiers in bioengineering and biotechnology 2023;11:1229387
Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance.
Hu HF, Gao GB, He X, Li YY, Li YJ, Li B, Pan Y, Wang Y, He QY
Journal of advanced research 2023 Sep;51:135-147
Journal of advanced research 2023 Sep;51:135-147
A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement.
Shen X, Wu W, Ying Y, Zhou L, Zhu H
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc 2023 Sep;49 Suppl 1:228-237
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc 2023 Sep;49 Suppl 1:228-237
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization.
Liu Y, Zhou Q, Ye F, Yang C, Jiang H
Neoplasia (New York, N.Y.) 2023 Sep;43:100928
Neoplasia (New York, N.Y.) 2023 Sep;43:100928
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Wen H, Qu C, Wang Z, Gao H, Liu W, Wang H, Sun H, Gu J, Yang Z, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
Yueju volatile oil plays an integral role in the antidepressant effect by up-regulating ERK/AKT-mediated GLT-1 expression to clear glutamate.
Zhang B, Su D, Song Y, Li H, Chen C, Liao L, Zhang H, Luo J, Yang M, Zhu G, Ai Z
Fitoterapia 2023 Sep;169:105583
Fitoterapia 2023 Sep;169:105583
Oridonin inhibits the occurrence and development of colorectal cancer by reversing the Warburg effect via reducing PKM2 dimer formation and preventing its entry into the nucleus.
Chen F, Liao J, Wu P, Cheng L, Ma Y, Zhang L, Leng X, Zhu X, Liu Z, Xie F
European journal of pharmacology 2023 Sep 5;954:175856
European journal of pharmacology 2023 Sep 5;954:175856
Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
Luo D, Liang Y, Wang Y, Ye F, Jin Y, Li Y, Han D, Wang Z, Chen B, Zhao W, Wang L, Chen X, Jiang L, Yang Q
Breast cancer research : BCR 2023 Sep 28;25(1):109
Breast cancer research : BCR 2023 Sep 28;25(1):109
Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.
Zhao Z, Li Y, Guo S, Chen Y, Yin H, Li Y, Cheng G, Tian L
International journal of molecular sciences 2023 Sep 25;24(19)
International journal of molecular sciences 2023 Sep 25;24(19)
Long-Term Exposure to Microcystin-LR Induces Gastric Toxicity by Activating the Mitogen-Activated Protein Kinase Signaling Pathway.
Liu Y, Li Y, Tan Q, Lv Y, Tang Y, Yang Y, Yao X, Yang F
Toxins 2023 Sep 18;15(9)
Toxins 2023 Sep 18;15(9)
Inhibition of FNDC1 suppresses gastric cancer progression by interfering with Gβγ-VEGFR2 complex formation.
Lu Y, Huang P, Zeng X, Liu W, Zhao R, Li J, Cao G, Hu Y, Xiao Q, Wu M, Huang W, Tang X, Liu X, Wei H
iScience 2023 Sep 15;26(9):107534
iScience 2023 Sep 15;26(9):107534
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Zhang L, Liang S, Zhang Z, Wang K, Cao J, Yao M, Qin L, Qu C, Miao J
International journal of molecular sciences 2023 Sep 12;24(18)
International journal of molecular sciences 2023 Sep 12;24(18)
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Yang Z, Wu S, He S, Han L, Zhou M, Yang J, Chen J, Wu G
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
Formin-related protein 1 facilitates proliferation and aggressive phenotype of clear cell renal cell carcinoma through MAPK/MMP2 pathway.
Ma G, Zhang B, Fu S, Lu J, Zhang L, Shang P, Yue Z
Molecular and cellular probes 2023 Oct;71:101921
Molecular and cellular probes 2023 Oct;71:101921
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Huangfu N, Ma H, Tian M, Zhang J, Wang Y, Li Z, Chen X, Cui H
Inflammation 2023 Oct;46(5):1725-1738
Inflammation 2023 Oct;46(5):1725-1738
Identification of a receptor tyrosine kinase inhibitor CP-724714 inhibits SADS-CoV related swine diarrhea coronaviruses infection in vitro.
Zhou L, Li C, Zhang R, Li Q, Sun Y, Feng Y, Lan T, Ma J
Virologica Sinica 2023 Oct;38(5):778-786
Virologica Sinica 2023 Oct;38(5):778-786
HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway.
Zhao B, Qiao H, Zhao Y, Gao Z, Wang W, Cui Y, Li J, Guo Z, Chuai X, Chiu S
Virologica Sinica 2023 Oct;38(5):680-689
Virologica Sinica 2023 Oct;38(5):680-689
Lens epithelial cell-derived exosome inhibits angiogenesis in ocular pathological neovascularization through its delivery of miR-146a-5p.
Pan T, Wu Y, Zhang X, Wang J, Wang X, Gu Q, Xu C, Fan Y, Li X, Xie P, Liu Q, Hu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23192
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23192
Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus.
Su Z, Lu J, Ling Z, Li W, Yang X, Cheng B, Tao X
Biochemical pharmacology 2023 Oct;216:115796
Biochemical pharmacology 2023 Oct;216:115796
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Ma Y, Zhang J, Li Y, Hu H, Ye Q, Yang C, Yang L, Zhang B, Ma T
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Meng M, Wang L, Yao Y, Lin D, Wang C, Yao J, Sun H, Liu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Transcriptome Analysis Revealed Potential Genes of Skeletal Muscle Thermogenesis in Mashen Pigs and Large White Pigs under Cold Stress.
Li W, Chen Y, Zhang Y, Zhao N, Zhang W, Shi M, Zhao Y, Cai C, Lu C, Gao P, Guo X, Li B, Kim SW, Yang Y, Cao G
International journal of molecular sciences 2023 Oct 24;24(21)
International journal of molecular sciences 2023 Oct 24;24(21)
FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke.
Guan X, Wei D, Liang Z, Xie L, Wang Y, Huang Z, Wu J, Pang T
ACS chemical neuroscience 2023 Oct 18;14(20):3839-3854
ACS chemical neuroscience 2023 Oct 18;14(20):3839-3854
Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation.
Kanwore K, Kanwore K, Guo X, Xia Y, Zhou H, Zhang L, Adzika GK, Joseph AA, Abiola AA, Mu P, Kambey PA, Noah MLN, Gao D
Inflammation and regeneration 2023 Oct 13;43(1):49
Inflammation and regeneration 2023 Oct 13;43(1):49
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Ke W, Wang B, Liao Z, Song Y, Li G, Ma L, Wang K, Li S, Hua W, Yang C
Journal of translational medicine 2023 Oct 10;21(1):711
Journal of translational medicine 2023 Oct 10;21(1):711
Multi-omics reveals aging-related pathway in natural aging mouse liver.
Tang CM, Zhang Z, Sun Y, Ding WJ, Yang XC, Song YP, Ling MY, Li XH, Yan R, Zheng YJ, Yu N, Zhang WH, Wang Y, Wang SP, Gao HQ, Zhao CL, Xing YQ
Heliyon 2023 Nov;9(11):e21011
Heliyon 2023 Nov;9(11):e21011
Ketamine counteracts sevoflurane-induced depressive-like behavior and synaptic plasticity impairments through the adenosine A2A receptor/ERK pathway in rats.
Yu W, Wu Z, Li X, Ding M, Xu Y, Zhao P
Molecular neurobiology 2023 Nov;60(11):6160-6175
Molecular neurobiology 2023 Nov;60(11):6160-6175
Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation.
Ge Z, Xu M, Ge Y, Huang G, Chen D, Ye X, Xiao Y, Zhu H, Yin R, Shen H, Ma G, Qi L, Wei G, Li D, Wei S, Zhu M, Ma H, Shi Z, Wang X, Ge X, Qian X
Cell reports 2023 Nov 28;42(11):113417
Cell reports 2023 Nov 28;42(11):113417
The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection.
Li Y, Cao H, Qiu D, Wang N, Wang Y, Wen T, Wang J, Zhu H
Cancer cell international 2023 Nov 16;23(1):272
Cancer cell international 2023 Nov 16;23(1):272
Study on the Alleviating Effect and Potential Mechanism of Ethanolic Extract of Limonium aureum (L.) Hill. on Lipopolysaccharide-Induced Inflammatory Responses in Macrophages.
Yang Z, Man J, Liu Y, Zhang H, Wu D, Shao D, Hao B, Wang S
International journal of molecular sciences 2023 Nov 13;24(22)
International journal of molecular sciences 2023 Nov 13;24(22)
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
Zhang F, Zou H, Li X, Liu J, Xie Y, Chen M, Yu J, Wu X, Guo B
Human cell 2023 May;36(3):1024-1040
Human cell 2023 May;36(3):1024-1040
N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
Wang J, Yu H, Dong W, Zhang C, Hu M, Ma W, Jiang X, Li H, Yang P, Xiang D
Gastroenterology 2023 May;164(6):990-1005
Gastroenterology 2023 May;164(6):990-1005
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Wang Z, Tan M, Su W, Huang W, Zhang J, Jia F, Cao G, Liu X, Song H, Ran H, Nie G, Wang H
Journal of medicinal chemistry 2023 May 11;66(9):6263-6273
Journal of medicinal chemistry 2023 May 11;66(9):6263-6273
An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma.
Si Z, Yang G, Wang X, Yu Z, Pang Q, Zhang S, Qian L, Ruan Y, Huang J, Yu L
Life science alliance 2023 Mar;6(3)
Life science alliance 2023 Mar;6(3)
Methionine sulfoxide suppresses adipogenic differentiation by regulating the mitogen-activated protein kinase signaling pathway.
Qin D, Lei Y, Xie W, Zheng Q, Peng Z, Liu Y, Dai B, Ma T, Wei P, Gao C, Guo X, Gao J, Zhao J, Du J, Zeng Q, Zhang Z, Dong X, Shen H
Cell biology international 2023 Mar;47(3):648-659
Cell biology international 2023 Mar;47(3):648-659
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.
He XY, Zhu MM, Zheng J, Wang CY, Zhao XK, Zhang BT, Zhou DC, Zhang S, Yang XX, Duan YJ, Han JH, Chen YL
Acta pharmacologica Sinica 2023 Mar;44(3):635-646
Acta pharmacologica Sinica 2023 Mar;44(3):635-646
The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis.
Wang Y, Peng M, Zhong Y, Xiong W, Zhu L, Jin X
Oncogene 2023 Mar;42(13):952-966
Oncogene 2023 Mar;42(13):952-966
Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.
Zhang L, Ma X, Shi R, Zhang L, Zhao R, Duan R, Qin Y, Gao S, Li X, Duan J, Li J
British journal of pharmacology 2023 Mar;180(5):628-646
British journal of pharmacology 2023 Mar;180(5):628-646
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation.
Ning W, Gao G, Zhou Y, Li WQ, Yang HH, Duan XB, Li X, Gong YB, Li D, Guo R
International immunopharmacology 2023 Mar;116:109747
International immunopharmacology 2023 Mar;116:109747
Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway.
Li Y, He B, Zhang C, He Y, Xia T, Zeng C
Nutrients 2023 Mar 9;15(6)
Nutrients 2023 Mar 9;15(6)
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway.
Zhao L, Miao Y, Shan B, Zhao C, Peng C, Gong J
Foods (Basel, Switzerland) 2023 Mar 30;12(7)
Foods (Basel, Switzerland) 2023 Mar 30;12(7)
Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation.
Cheng X, Jia X, Wang C, Zhou S, Chen J, Chen L, Chen J
World journal of surgical oncology 2023 Mar 28;21(1):112
World journal of surgical oncology 2023 Mar 28;21(1):112
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways.
Wang Z, Jian G, Chen T, Chen Y, Li J, Wang N
European journal of histochemistry : EJH 2023 Mar 1;67(1)
European journal of histochemistry : EJH 2023 Mar 1;67(1)
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.
Shao L, Wu B, Liu C, Chong W
Shock (Augusta, Ga.) 2023 Mar 1;59(3):449-459
Shock (Augusta, Ga.) 2023 Mar 1;59(3):449-459
Chitosan targets PI3K/Akt/FoxO3a axis to up-regulate FAM172A and suppress MAPK/ERK pathway to exert anti-tumor effect in osteosarcoma.
Ren Z, Xiao W, He M, Bai L
Chemico-biological interactions 2023 Mar 1;373:110354
Chemico-biological interactions 2023 Mar 1;373:110354
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
Li L, Wang X, Hu K, Liu X, Qiu L, Bai C, Cui Y, Wang B, Wang Z, Wang H, Cheng R, Hua J, Hai L, Wang M, Liu M, Song Z, Xiao C, Li B
Oncogene 2023 Jun;42(27):2166-2182
Oncogene 2023 Jun;42(27):2166-2182
Exercise-induced endothelial Mecp2 lactylation suppresses atherosclerosis via the Ereg/MAPK signalling pathway.
Wang Y, Chen L, Zhang M, Li X, Yang X, Huang T, Ban Y, Li Y, Li Q, Zheng Y, Sun Y, Wu J, Yu B
Atherosclerosis 2023 Jun;375:45-58
Atherosclerosis 2023 Jun;375:45-58
Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex.
Gu L, Jin X, Liang H, Yang C, Zhang Y
Pharmacological research 2023 Jun;192:106789
Pharmacological research 2023 Jun;192:106789
The Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple.
Che R, Liu C, Wang Q, Tu W, Wang P, Li C, Gong X, Mao K, Feng H, Huang L, Li P, Ma F
Autophagy 2023 Jun;19(6):1745-1763
Autophagy 2023 Jun;19(6):1745-1763
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway.
Wu Y, Duan Z, Qu L, Zhang Y, Zhu C, Fan D
Food & function 2023 Jun 6;14(11):5167-5181
Food & function 2023 Jun 6;14(11):5167-5181
Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production.
Yan Y, Yang X, Han N, Liu Y, Liang Q, Li LG, Hu J, Li TF, Xu Z
Journal of nanobiotechnology 2023 Jun 29;21(1):204
Journal of nanobiotechnology 2023 Jun 29;21(1):204
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
Jiang Q, Lei Z, Wang Z, Wang Q, Zhang Z, Liu X, Xing B, Li S, Guo X, Liu Y, Li X, Qi Y, Shu K, Zhang H, Huang Y, Lei T
Cancers 2023 Jun 27;15(13)
Cancers 2023 Jun 27;15(13)
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Cai Y, Chen P, Xu H, Li S, Zhao B, Fan Y, Wang F, Zhang Y
International journal of molecular sciences 2023 Jun 26;24(13)
International journal of molecular sciences 2023 Jun 26;24(13)
Endothelial progenitor cell-derived exosomes inhibit pulmonary artery smooth muscle cell in vitro proliferation and resistance to apoptosis by modulating the Mitofusin-2 and Ras-Raf-ERK1/2 signaling pathway.
Liu P, Gao S, Li Z, Pan S, Luo G, Ji Z
European journal of pharmacology 2023 Jun 15;949:175725
European journal of pharmacology 2023 Jun 15;949:175725
Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia.
Mishima S, Mitsui T, Tani K, Ooba H, Mitoma T, Ohira A, Maki J, Kirino S, Eto E, Hayata K, Masuyama H
Placenta 2023 Jul;138:44-50
Placenta 2023 Jul;138:44-50
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Deng X, Zeng Y, Qiu X, Zhong M, Xiong X, Luo M, Zhang J, Chen X
Leukemia research 2023 Jul;130:107312
Leukemia research 2023 Jul;130:107312
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Shen PC, Huang SH, Liu ZM, Lu CC, Chou SH, Tien YC
International immunopharmacology 2023 Jul;120:110295
International immunopharmacology 2023 Jul;120:110295
Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice.
Du J, Zhang F, Chen M, Xiao Y, Zhang L, Dong L, Dong D, Wu B
The Journal of pharmacy and pharmacology 2023 Jul 5;75(7):886-897
The Journal of pharmacy and pharmacology 2023 Jul 5;75(7):886-897
A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer.
Song R, Guo P, Ren X, Zhou L, Li P, Rahman NA, Wołczyński S, Li X, Zhang Y, Liu M, Liu J, Li X
Molecular cancer 2023 Jul 5;22(1):104
Molecular cancer 2023 Jul 5;22(1):104
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Jie Li Z, Bing Luo C, Liang Wang H, Sun J, Qian Yang Q, Lang Zhou Y
International journal of pharmaceutics 2023 Jul 25;642:123190
International journal of pharmaceutics 2023 Jul 25;642:123190
Elevated retinal fibrosis in experimental myopia is involved in the activation of the PI3K/AKT/ERK signaling pathway.
Bao B, Liu J, Li T, Yang Z, Wang G, Xin J, Bi H, Guo D
Archives of biochemistry and biophysics 2023 Jul 15;743:109663
Archives of biochemistry and biophysics 2023 Jul 15;743:109663
Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.
Wan Q, Xu J, Zhu C, Liu X, Tu Y, Lei J, Yu J
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10349-10360
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10349-10360
Resveratrol May Reduce the Degree of Periodontitis by Regulating ERK Pathway in Gingival-Derived MSCs.
Jiang H, Ni J, Hu L, Xiang Z, Zeng J, Shi J, Chen Q, Li W
International journal of molecular sciences 2023 Jul 10;24(14)
International journal of molecular sciences 2023 Jul 10;24(14)
TRPC6 promotes daunorubicin-induced mitochondrial fission and cell death in rat cardiomyocytes with the involvement of ERK1/2-DRP1 activation.
Xu LX, Wang RX, Jiang JF, Yi GC, Chang JJ, He RL, Jiao HX, Zheng B, Gui LX, Lin JJ, Huang ZH, Lin MJ, Wu ZJ
Toxicology and applied pharmacology 2023 Jul 1;470:116547
Toxicology and applied pharmacology 2023 Jul 1;470:116547
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
Liu WY, Li Y, Li Y, Xu LZ, Jia JP
Molecular neurobiology 2023 Jan;60(1):133-144
Molecular neurobiology 2023 Jan;60(1):133-144
Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.
Wang Q, Wang F, Li X, Ma Z, Jiang D
Phytotherapy research : PTR 2023 Jan;37(1):111-123
Phytotherapy research : PTR 2023 Jan;37(1):111-123
HIV Tat-Conjugated Histone H3 Peptides Induce Tumor Cell Death Via Cellular Stress Responses.
Xu Q, Zhu F, Pan Y, Ren Y, Li J, Huang N, Liu K, Wang Y
Human gene therapy 2023 Jan;34(1-2):42-55
Human gene therapy 2023 Jan;34(1-2):42-55
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Li M, Zhang Y, Han T, Guan L, Fan D, Wu Q, Liu J, Xu Y, Fan Y
Phytochemistry 2023 Jan;205:113487
Phytochemistry 2023 Jan;205:113487
Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation.
Shi M, Yang S, Huang X, Wang S, Li W, Yun J, Lu C, Yang Y, Cai C, Gao P, Guo X, Li B, Cao G
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13822
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13822
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.
Zheng HL, Sun SY, Jin T, Zhang M, Zeng Y, Liu Q, Yang K, Wei R, Pan Z, Lin F
Molecular pain 2023 Jan-Dec;19:17448069231152125
Molecular pain 2023 Jan-Dec;19:17448069231152125
Deficit of PKHD1L1 in the dentate gyrus increases seizure susceptibility in mice.
Yu J, Wang G, Chen Z, Wan L, Zhou J, Cai J, Liu X, Wang Y
Human molecular genetics 2023 Jan 13;32(3):506-519
Human molecular genetics 2023 Jan 13;32(3):506-519
Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis.
Yang N, Li M, Wu L, Song Y, Yu S, Wan Y, Cheng W, Yang B, Mou X, Yu H, Zheng J, Li X, Yu X
Journal of nanobiotechnology 2023 Jan 13;21(1):13
Journal of nanobiotechnology 2023 Jan 13;21(1):13
LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer.
Wu T, Li X, Yan G, Tan Z, Zhao D, Liu S, Wang H, Xiang Y, Chen W, Lu H, Liao X, Li Y, Lu Z
Journal of experimental & clinical cancer research : CR 2023 Jan 10;42(1):14
Journal of experimental & clinical cancer research : CR 2023 Jan 10;42(1):14
CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.
Xing F, Gao H, Chen G, Sun L, Sun J, Qiao X, Xue J, Liu C
Molecular cancer 2023 Jan 10;22(1):6
Molecular cancer 2023 Jan 10;22(1):6
Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.
Lin H, Li W, Shen Z, Bei Y, Wei T, Yu Z, Dai Y, Dai H
Neuroscience letters 2023 Jan 1;792:136941
Neuroscience letters 2023 Jan 1;792:136941
Elevated PGT promotes proliferation and inhibits cell apoptosis in preeclampsia by Erk signaling pathway.
Pang H, Lei D, Huang J, Guo Y, Fan C
Molecular and cellular probes 2023 Feb;67:101896
Molecular and cellular probes 2023 Feb;67:101896
Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma.
Zhu XF, Sun ZL, Ma J, Hu B, Yu MC, Liu XJ, Yang P, Xu Y, Ju D, Mu Q
Phytotherapy research : PTR 2023 Feb;37(2):592-610
Phytotherapy research : PTR 2023 Feb;37(2):592-610
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Teng L, Shen Y, Qu Y, Yang L, Yang Y, Jian X, Fan S, Zhang L, Fu Q
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity.
Liu XM, Li Z, Xie XR, Wang JQ, Qiao X, Qiao X, Xie CZ, Xu JY
Journal of medicinal chemistry 2023 Feb 9;66(3):1852-1872
Journal of medicinal chemistry 2023 Feb 9;66(3):1852-1872
Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia.
Guo Q, Fan Y, Wang Q, Li B, Qiu W, Qi Y, Pan Z, Zhang S, Zhao S, Yang K, Xu H, Li M, Gao Z, Xu J, Wang H, Wang S, Tang Q, Qiu J, Guo X, Deng L, Zhang P, Zhao R, Xue H, Wang C, Li G
Cell death & disease 2023 Feb 21;14(2):147
Cell death & disease 2023 Feb 21;14(2):147
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Wang Y, Liu Q, Chu C, Li L, Wang Z, Liu Q, Wu G, Wei X, An L, Ma J
Toxicology and applied pharmacology 2023 Feb 15;461:116385
Toxicology and applied pharmacology 2023 Feb 15;461:116385
Gelatin methacryloyl (GelMA) loaded with concentrated hypoxic pretreated adipose-derived mesenchymal stem cells(ADSCs) conditioned medium promotes wound healing and vascular regeneration in aged skin.
Li S, Sun J, Yang J, Yang Y, Ding H, Yu B, Ma K, Chen M
Biomaterials research 2023 Feb 13;27(1):11
Biomaterials research 2023 Feb 13;27(1):11
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Li Y, Zang J, Wang X, Feng X, Qiu F
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Wang Z, Li L, Chu C, Wei X, Liu Q, Wang R, Zhang G, Wu G, Wang Y, An L, Li X
International journal of oncology 2023 Dec;63(6)
International journal of oncology 2023 Dec;63(6)
Wen-Shen-Tong-Luo-Zhi-Tong Decoction regulates bone-fat balance in osteoporosis by adipocyte-derived exosomes.
Wang L, Pan Y, Liu M, Sun J, Yun L, Tu P, Wu C, Yu Z, Han Z, Li M, Guo Y, Ma Y
Pharmaceutical biology 2023 Dec;61(1):568-580
Pharmaceutical biology 2023 Dec;61(1):568-580
Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.
Yu B, Zhou M, Dong Z, Zheng H, Zhao Y, Zhou J, Zhang C, Wei F, Yu G, Liu WJ, Liu H, Wang Y
Pharmaceutical biology 2023 Dec;61(1):1222-1233
Pharmaceutical biology 2023 Dec;61(1):1222-1233
Mechanisms of dihydromyricetin against hepatocellular carcinoma elucidated by network pharmacology combined with experimental validation.
Zhang S, Shi YN, Gu J, He P, Ai QD, Zhou XD, Wang W, Qin L
Pharmaceutical biology 2023 Dec;61(1):1108-1119
Pharmaceutical biology 2023 Dec;61(1):1108-1119
Sema3A inactivates the ERK/JNK signalling pathways to alleviate inflammation and oxidative stress in lipopolysaccharide-stimulated rat endothelial cells and lung tissues.
Qiu Q, Yu X, Chen Q, He X
Autoimmunity 2023 Dec;56(1):2200908
Autoimmunity 2023 Dec;56(1):2200908
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Wang R, Li J, Fu Y, Li Y, Qi Y, Li C, Gao F, Li C
Biochemical pharmacology 2023 Dec;218:115874
Biochemical pharmacology 2023 Dec;218:115874
Herbal compound cepharanthine attenuates inflammatory arthritis by blocking macrophage M1 polarization.
Lu C, Cheng RJ, Zhang Q, Hu Y, Pu Y, Wen J, Zhong Y, Tang Z, Wu L, Wei S, Tsou PS, Fox DA, Li S, Luo Y, Liu Y
International immunopharmacology 2023 Dec;125(Pt B):111175
International immunopharmacology 2023 Dec;125(Pt B):111175
Liensinine improves AngII-induced vascular remodeling via MAPK/TGF-β1/Smad2/3 signaling.
Jia P, Chen D, Zhu Y, Wang M, Zeng J, Zhang L, Cai Q, Lian D, Zhao C, Xu Y, Chu J, Lin S, Peng J, Lin W
Journal of ethnopharmacology 2023 Dec 5;317:116768
Journal of ethnopharmacology 2023 Dec 5;317:116768
The ethanol extract of Scutellaria baicalensis Georgi attenuates complete Freund's adjuvant (CFA)-induced inflammatory pain by suppression of P2X3 receptor.
Gao L, Zhao JX, Qin XM, Zhao J
Journal of ethnopharmacology 2023 Dec 5;317:116762
Journal of ethnopharmacology 2023 Dec 5;317:116762
Modification of osimertinib to discover new potent EGFR(C797S)-TK inhibitors.
Xi XX, Zhao HY, Mao YZ, Xin M, Zhang SQ
European journal of medicinal chemistry 2023 Dec 5;261:115865
European journal of medicinal chemistry 2023 Dec 5;261:115865
Discovery of highly potent and selective KRAS(G12C) degraders by VHL-recruiting PROTACs for the treatment of tumors with KRAS(G12C)-Mutation.
Yang N, Fan Z, Sun S, Hu X, Mao Y, Jia C, Cai X, Xu T, Li B, Li Y, Han L, Wei T, Qian X, Qin W, Li P, Zheng Z, Li S
European journal of medicinal chemistry 2023 Dec 5;261:115857
European journal of medicinal chemistry 2023 Dec 5;261:115857
Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.
Guo Y, Tian J, Guo Y, Wang C, Chen C, Cai S, Yu W, Sun B, Yan J, Li Z, Fan J, Qi Q, Zhang D, Jin W, Hua Z, Chen G
Cell reports 2023 Dec 26;42(12):113511
Cell reports 2023 Dec 26;42(12):113511
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE(-/-) Mice.
Ren J, Liu J, Zhang J, Hu X, Cui Y, Wei X, Ma Y, Li X, Zhao Y
International journal of molecular sciences 2023 Dec 23;25(1)
International journal of molecular sciences 2023 Dec 23;25(1)
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation.
Yuan S, Che Y, Wang Z, Xing K, Xie X, Chen Y
Journal of translational medicine 2023 Dec 20;21(1):925
Journal of translational medicine 2023 Dec 20;21(1):925
GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.
Bao H, Peng Z, Cheng X, Jian C, Li X, Shi Y, Zhu W, Hu Y, Jiang M, Song J, Fang F, Chen J, Shu X
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344
Ultrasound-targeted microbubble destruction promotes PDGF-primed bone mesenchymal stem cell transplantation for myocardial protection in acute Myocardial Infarction in rats.
Sun Z, Cai Y, Chen Y, Jin Q, Zhang Z, Zhang L, Li Y, Huang L, Wang J, Yang Y, Lv Q, Han Z, Xie M, Zhu X
Journal of nanobiotechnology 2023 Dec 15;21(1):481
Journal of nanobiotechnology 2023 Dec 15;21(1):481
Banxia Xiexin decoction ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis via inhibiting serine-threonine protein kinase (Akt)/mitogen-activated protein kinase (MAPK) signaling pathway.
Ji W, Liu W, Huo Y, Hu C, Zhang Y
Biotechnology and applied biochemistry 2023 Aug;70(4):1530-1542
Biotechnology and applied biochemistry 2023 Aug;70(4):1530-1542
Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo.
Xiao Y, He Y, Xu C, Li M, Hu F, Wang W, Wang Z, Cao Y
Environmental toxicology 2023 Aug;38(8):1925-1938
Environmental toxicology 2023 Aug;38(8):1925-1938
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Wang X, Zhou Y, Sun Q, Zhang Q, Zhou H, Zhang J, Du Y, Wang Y, Yuan K, Xu L, Zhang M, Yan D, Zeng L, Xu K, Sang W
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
The Inhibitory Effect of RADKPS on Pyroptosis of Nucleus Pulposus-Derived Mesenchymal Stem Cells.
Zhu C, Zhou Q, Tang L, Xuan A, Xu C, Wang Z, Ruan D
Tissue engineering. Part A 2023 Aug;29(15-16):424-438
Tissue engineering. Part A 2023 Aug;29(15-16):424-438
ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy.
Mo W, Liu S, Zhao X, Wei F, Li Y, Sheng X, Cao W, Ding M, Zhang W, Chen X, Meng L, Yao S, Diao W, Wei H, Guo H
Advanced healthcare materials 2023 Aug;12(21):e2300191
Advanced healthcare materials 2023 Aug;12(21):e2300191
PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.
Cheng M, Cao H, Yao P, Guan J, Wu P, Ji H, Jiang S, Yuan Y, Fu L, Zheng Q, Li Q
Cell death & disease 2023 Aug 25;14(8):558
Cell death & disease 2023 Aug 25;14(8):558
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Li GH, Liu X, Feng LJ, Zhang L
Neoplasma 2023 Aug 20;
Neoplasma 2023 Aug 20;
The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer.
Li DM, Zhu FC, Wei J, Xie JX, He JH, Wei DM, Li Y, Lai KD, Liu LM, Su QB, Wei GN, Wang B, Liu YC
Journal of ethnopharmacology 2023 Aug 10;312:116454
Journal of ethnopharmacology 2023 Aug 10;312:116454
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
Huang H, Li X, Zha D, Lin H, Yang L, Wang Y, Xu L, Wang L, Lei T, Zhou Z, Xiao YF, Xin HB, Fu M, Qian Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.
Shan F, Shen S, Wang X, Chen G
International journal of oncology 2023 Apr;62(4)
International journal of oncology 2023 Apr;62(4)
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling.
Wu C, Zhu G, Qiu F, Ren F, Lin B, Zhang D, Yang Q, Huang C
Virologica Sinica 2023 Apr;38(2):276-284
Virologica Sinica 2023 Apr;38(2):276-284
Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell.
Zhou W, Ma J, Zhao H, Wang Q, Guo X, Chen L, Cao Z, Xu J, Zhang B, Zhou X
Molecular & cellular proteomics : MCP 2023 Apr;22(4):100520
Molecular & cellular proteomics : MCP 2023 Apr;22(4):100520
Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling.
Wang H, Zhou HC, Ren RL, Du SX, Guo ZK, Shen XH
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Apr;22(2):179-189
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Apr;22(2):179-189
Exosomes incorporated with black phosphorus quantum dots attenuate retinal angiogenesis via disrupting glucose metabolism.
Gui X, Zhang H, Zhang R, Li Q, Zhu W, Nie Z, Zhao J, Cui X, Hao W, Wen X, Shen W, Song H
Materials today. Bio 2023 Apr;19:100602
Materials today. Bio 2023 Apr;19:100602
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Ma Y, Du Y, Yang J, He Q, Wang H, Lin X
Physiological research 2023 Apr 30;72(2):235-249
Physiological research 2023 Apr 30;72(2):235-249
The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
Zhang M, Yang K, Wang QH, Xie L, Liu Q, Wei R, Tao Y, Zheng HL, Lin N, Xu H, Yang L, Wang H, Zhang T, Xue Z, Cao JL, Pan Z
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 26;43(17):3009-3027
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 26;43(17):3009-3027
Promoted Skin Wound Healing by Tail-Amputated Eisenia foetida Proteins via the Ras/Raf/MEK/ERK Signaling Pathway.
Li T, Sun Y, Wang J, Zhang C, Sun Y
ACS omega 2023 Apr 18;8(15):13935-13943
ACS omega 2023 Apr 18;8(15):13935-13943
SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway.
Shang K, Ma N, Che J, Li H, Hu J, Sun H, Cao B
BMC cancer 2023 Apr 11;23(1):335
BMC cancer 2023 Apr 11;23(1):335
Subchronic Microcystin-LR Aggravates Colorectal Inflammatory Response and Barrier Disruption via Raf/ERK Signaling Pathway in Obese Mice.
Yang Y, Zheng S, Chu H, Du C, Chen M, Emran MY, Chen J, Yang F, Tian L
Toxins 2023 Apr 1;15(4)
Toxins 2023 Apr 1;15(4)
CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study.
Huang X, Liu W, Liu C, Hu J, Wang B, Ren A, Huang X, Yuan Y, Liu J, Li M
Frontiers in molecular biosciences 2022;9:983410
Frontiers in molecular biosciences 2022;9:983410
7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells.
Fan Y, Li J, Huang L, Wang K, Zhao M
Ophthalmic research 2022;65(6):678-684
Ophthalmic research 2022;65(6):678-684
Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction.
Yuan Y, Wu H, Shuai B, Liu C, Zhu F, Gao F, Wei C, Fan H
Current pharmaceutical design 2022;28(42):3456-3468
Current pharmaceutical design 2022;28(42):3456-3468
Sufentanil Alleviates Sepsis-Induced Myocardial Injury and Stress Response in Rats through the ERK/GSK-3β Signaling Axis.
Zang H, Shao G, Lou Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9630716
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9630716
Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain.
Xi P, Mao R, Wu S, Liu L, Cai C, Lu L, Zhang C, Li Y
Mediators of inflammation 2022;2022:6010952
Mediators of inflammation 2022;2022:6010952
Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors.
Zhang M, Wang L, Liu W, Wang T, De Sanctis F, Zhu L, Zhang G, Cheng J, Cao Q, Zhou J, Tagliabue A, Bronte V, Yan D, Wan X, Yu G
Journal of immunology research 2022;2022:2253436
Journal of immunology research 2022;2022:2253436
Systematic Pharmacology-Based Strategy to Explore the Mechanism of Bufei Huoxue Capsule in the Treatment of Chronic Obstructive Pulmonary Disease.
Shi L, Yan J, Meng Y, Wang G, Du J, Feng C
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1129567
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1129567
Smart thermosensitive poloxamer hydrogels loaded with Nr-CWs for the treatment of diabetic wounds.
Wang J, Zhao B, Sun L, Jiang L, Li Q, Jin P
PloS one 2022;17(12):e0279727
PloS one 2022;17(12):e0279727
METTL3 Facilitates Tumor Progression by COL12A1/MAPK Signaling Pathway in Esophageal Squamous Cell Carcinoma.
Li J, Li Z, Xu Y, Huang C, Shan B
Journal of Cancer 2022;13(6):1972-1984
Journal of Cancer 2022;13(6):1972-1984
Bu-Gu-Sheng-Sui decoction promotes osteogenesis via activating the ERK/Smad signaling pathways.
Liu N, Qi B, Zhang Y, Fang S, Sun C, Li Q, Wei X
Frontiers in pharmacology 2022;13:976121
Frontiers in pharmacology 2022;13:976121
Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.
Qin X, Liu B, Gao F, Hu Y, Chen Z, Xu J, Zhang X
Frontiers in physiology 2022;13:856699
Frontiers in physiology 2022;13:856699
Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro.
He J, Xu D, Wang L, Yu X
Frontiers in pharmacology 2022;13:1079251
Frontiers in pharmacology 2022;13:1079251
Dysfunction of CCR1(+) decidual macrophages is a potential risk factor in the occurrence of unexplained recurrent pregnancy loss.
Sang Y, Li Y, Xu L, Chen J, Li D, Du M
Frontiers in immunology 2022;13:1045532
Frontiers in immunology 2022;13:1045532
High-Metastatic Melanoma Cells Promote the Metastatic Capability of Low-Metastatic Melanoma Cells via Exosomal Transfer of miR-411-5p.
Chen H, Zeng B, Li X, Zhao Q, Liu D, Chen Y, Zhang Y, Wang J, Xing HR
Frontiers in oncology 2022;12:895164
Frontiers in oncology 2022;12:895164
The Specifically Androgen-Regulated Gene (SARG) Promotes Papillary Thyroid Carcinoma (PTC) Lymphatic Metastasis Through Vascular Endothelial Growth Factor C (VEGF-C) and VEGF Receptor 3 (VEGFR-3) Axis.
Xu SJ, Jin B, Zhao WJ, Chen XX, Tong YY, Ding XF, Chen YY, Wang DH, Wang ZM, Dai BQ, Chen S, Liang Y, Chen G, Pan SJ, Xu LL
Frontiers in oncology 2022;12:817660
Frontiers in oncology 2022;12:817660
Poloxamer 407 and Hyaluronic Acid Thermosensitive Hydrogel-Encapsulated Ginsenoside Rg3 to Promote Skin Wound Healing.
Peng X, Ding C, Zhao Y, Hao M, Liu W, Yang M, Xiao F, Zheng Y
Frontiers in bioengineering and biotechnology 2022;10:831007
Frontiers in bioengineering and biotechnology 2022;10:831007
HIV-1 Tat Protein-Mediated Inflammatory Response Inhibits the Erythroid Hematopoietic Support Function of Bone Marrow Mesenchymal Stem Cells.
Wang X, Chen M, Ma S, Ding Y, Zhou C, Yuan Y
AIDS research and human retroviruses 2022 Sep;38(9):753-763
AIDS research and human retroviruses 2022 Sep;38(9):753-763
Traditional herbal formula Jiao-tai-wan improves chronic restrain stress-induced depression-like behaviors in mice.
Tang Y, Wang H, Nie K, Gao Y, Su H, Wang Z, Lu F, Huang W, Dong H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113284
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113284
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Adediran S, Wang L, Khan MA, Guang W, Fan X, Dan H, Qi J, Jay SM, Carrier F, Hussain A
Cancers 2022 Sep 23;14(19)
Cancers 2022 Sep 23;14(19)
Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia.
Kang JB, Chen L, Leng XJ, Wang JJ, Cheng Y, Wu SH, Ma YY, Yang LJ, Cao YH, Yang X, Tong ZJ, Wu JZ, Wang YB, Zhou H, Liu JC, Ding N, Dai WC, Yu YC, Xue X, Sun SL, Dai XB, Chang L, Wang XL, Li NG, Shi ZH
Bioorganic & medicinal chemistry 2022 Sep 15;70:116937
Bioorganic & medicinal chemistry 2022 Sep 15;70:116937
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Xu Z, Sun X, Ding B, Zi M, Ma Y
Transplant immunology 2022 Oct;74:101664
Transplant immunology 2022 Oct;74:101664
Combination of RSK inhibitor LJH-685 and FLT3 inhibitor FF-10101 promoted apoptosis and proliferation inhibition of AML cell lines.
Zhang S, Liu J, Lu ZY, Xue YT, Mu XR, Liu Y, Cao J, Li ZY, Li F, Xu KL, Wu QY
Cellular oncology (Dordrecht, Netherlands) 2022 Oct;45(5):1005-1018
Cellular oncology (Dordrecht, Netherlands) 2022 Oct;45(5):1005-1018
Cpd-0225 attenuates renal fibrosis via inhibiting ALK5.
Xie SS, Dong ZH, He Y, Chen ZW, Yang Q, Ma WX, Li C, Chen Y, Wang JN, Yu JT, Xu CH, Ni WJ, Hou R, Suo XG, Wen JG, Jin J, Li J, Liu MM, Meng XM
Biochemical pharmacology 2022 Oct;204:115240
Biochemical pharmacology 2022 Oct;204:115240
Identification of four STAT3 isoforms and functional investigation of IL-6/JAK2/STAT3 pathway in blunt snout bream (Megalobrama amblycephala).
Wang J, Sun Q, Wu J, Tian W, Wang H, Liu H
Developmental and comparative immunology 2022 Oct;135:104484
Developmental and comparative immunology 2022 Oct;135:104484
Triclocarban evoked neutrophil extracellular trap formation in common carp (Cyprinus carpio L.) by modulating SIRT3-mediated ROS crosstalk with ERK1/2/p38 signaling.
Li S, Wang Y, Yu D, Zhang Y, Wang X, Shi M, Xiao Y, Li X, Xiao H, Chen L, Xiong X
Fish & shellfish immunology 2022 Oct;129:85-95
Fish & shellfish immunology 2022 Oct;129:85-95
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939
Bioorganic chemistry 2022 Oct;127:105939
Exosomal DNAJB11 promotes the development of pancreatic cancer by modulating the EGFR/MAPK pathway.
Liu P, Zu F, Chen H, Yin X, Tan X
Cellular & molecular biology letters 2022 Oct 8;27(1):87
Cellular & molecular biology letters 2022 Oct 8;27(1):87
ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8.
Cui X, Pei X, Wang H, Feng P, Qin H, Liu S, Yan Q, Liu J
Cells 2022 Oct 6;11(19)
Cells 2022 Oct 6;11(19)
Autophagy triggered by the ROS/ERK signaling pathway protects mouse embryonic palatal cells from apoptosis induced by nicotine.
Chen J, Yao Y, Wang Y, Wang X, Peng X, Li T, Liu Y, Du J
Environmental science and pollution research international 2022 Nov;29(54):81909-81922
Environmental science and pollution research international 2022 Nov;29(54):81909-81922
Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa.
Zhang X, Cao Y, Pan D, Yao X, Wang F, Zhang G, Luo Y
Phytochemistry 2022 Nov;203:113378
Phytochemistry 2022 Nov;203:113378
Non-Muscle MLCK Contributes to Endothelial Cell Hyper-Proliferation through the ERK Pathway as a Mechanism for Vascular Remodeling in Pulmonary Hypertension.
Anis M, Gonzales J, Halstrom R, Baig N, Humpal C, Demeritte R, Epshtein Y, Jacobson JR, Fraidenburg DR
International journal of molecular sciences 2022 Nov 7;23(21)
International journal of molecular sciences 2022 Nov 7;23(21)
Orally Administered Ginkgolide C Attenuates DSS-Induced Colitis by Maintaining Gut Barrier Integrity, Inhibiting Inflammatory Responses, and Regulating Intestinal Flora.
Xu D, Zhuang L, Gao S, Ma H, Cheng J, Liu J, Liu D, Fu S, Hu G
Journal of agricultural and food chemistry 2022 Nov 23;70(46):14718-14731
Journal of agricultural and food chemistry 2022 Nov 23;70(46):14718-14731
Effects of Camk2b Overexpression and Underexpression on the Proteome of Rat Hippocampal Neurons.
Yang C, Zhang M, Li S, Yi F, Huang H, Xie H, Liu H, Huang R, Zhou J
Neuroscience 2022 Nov 1;503:58-68
Neuroscience 2022 Nov 1;503:58-68
Effects of thymoquinone against angiotensin II‑induced cardiac damage in apolipoprotein E‑deficient mice.
Zhang L, Zhang H, Ma J, Wang Y, Pei Z, Ding H
International journal of molecular medicine 2022 May;49(5)
International journal of molecular medicine 2022 May;49(5)
Optimization of the saffron compound essence formula and its effect on preventing skin photoaging.
Li Q, Liu L, Jiang S, Xu Z, Lin S, Tong Y, Wang P
Journal of cosmetic dermatology 2022 Mar;21(3):1251-1262
Journal of cosmetic dermatology 2022 Mar;21(3):1251-1262
Immunomodulatory activity of aqueous extract from Crassostrea sikamea in the splenocytes of Sprague-Dawley rats.
Guo G, Kong Y, Su J, Wang G, Zhang M, Wang S, Song Z
Food science & nutrition 2022 Mar;10(3):813-821
Food science & nutrition 2022 Mar;10(3):813-821
Downregulation of lncRNA SNHG16 inhibits vascular smooth muscle cell proliferation and migration in cerebral atherosclerosis by targeting the miR-30c-5p/SDC2 axis.
Yang SN, Zhong LY, Sun YH, Wang C, Ru WJ, Liu RZ, Dai W, Xie XM, Li SD
Heart and vessels 2022 Jun;37(6):1085-1096
Heart and vessels 2022 Jun;37(6):1085-1096
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
Han X, Zhang J, Zhou L, Wei J, Tu Y, Shi Q, Zhang Y, Ren J, Wang Y, Ying H, Liang G
Phytotherapy research : PTR 2022 Jun;36(6):2511-2523
Phytotherapy research : PTR 2022 Jun;36(6):2511-2523
Blockade of mIL-6R alleviated lipopolysaccharide-induced systemic inflammatory response syndrome by suppressing NF-κB-mediated Ccl2 expression and inflammasome activation.
Dai JM, Zhang XQ, Zhang JJ, Yang WJ, Yang XM, Bian H, Chen ZN
MedComm 2022 Jun;3(2):e132
MedComm 2022 Jun;3(2):e132
A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells.
Wang L, Gao T, Li Y, Xie Y, Zeng S, Tai C, Feng Y, Shen P, Wang B
Stem cell research & therapy 2022 Jun 17;13(1):259
Stem cell research & therapy 2022 Jun 17;13(1):259
MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway.
Wang Y, Zhang J, Chu X, Wang M, Xin Y, Liu S
Lipids in health and disease 2022 Jun 15;21(1):54
Lipids in health and disease 2022 Jun 15;21(1):54
Near-Infrared Light-Responsive Nanoinhibitors for Tumor Suppression through Targeting and Regulating Anion Channels.
Li C, Shi S, Gao D, Li B, Song G, Chen Y, An H, Xing C
ACS applied materials & interfaces 2022 Jul 20;14(28):31715-31726
ACS applied materials & interfaces 2022 Jul 20;14(28):31715-31726
Effect of Qingyangshen glycosides on social defeat mice model.
Liu D, Wang J, Chang L, Zhu Q, Jiang N, Azhar M, Zeng G
Journal of ethnopharmacology 2022 Jul 15;293:115253
Journal of ethnopharmacology 2022 Jul 15;293:115253
Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway.
Su D, Liao L, Zeng Q, Liao Z, Liu Y, Jin C, Zhu G, Chen C, Yang M, Ai Z, Song Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153833
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153833
Investigation of cell cytotoxic activity and molecular mechanism of 5β,19-epoxycucurbita-6,23(E)-diene-3β,19(R),25-triol isolated from Momordica charantia on hepatoma cells.
Yuan MK, Kao JW, Wu WT, Chen CR, Chang CI, Wu YJ
Pharmaceutical biology 2022 Dec;60(1):1214-1223
Pharmaceutical biology 2022 Dec;60(1):1214-1223
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.
Li F, Mao Q, Wang J, Zhang X, Lv X, Wu B, Yan T, Jia Y
Metabolic brain disease 2022 Dec;37(8):2965-2978
Metabolic brain disease 2022 Dec;37(8):2965-2978
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites.
Zhang M, Zhang J, Wang C, Yan JK, Yi J, Ning J, Huo XK, Yu ZL, Zhang BJ, Sun CP, Ma XC
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15104-15115
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15104-15115
The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
Wu S, Liu H, Zhou M, Shang Y, Luo L, Chen J, Yang J
Journal of reproductive immunology 2022 Aug;152:103647
Journal of reproductive immunology 2022 Aug;152:103647
Downregulation of IL-8 and IL-10 by the Activation of Ca(2+)-Activated K(+) Channel K(Ca)3.1 in THP-1-Derived M(2) Macrophages.
Ohya S, Matsui M, Kajikuri J, Kito H, Endo K
International journal of molecular sciences 2022 Aug 3;23(15)
International journal of molecular sciences 2022 Aug 3;23(15)
Rhodococcus equi-Derived Extracellular Vesicles Promoting Inflammatory Response in Macrophage through TLR2-NF-κB/MAPK Pathways.
Xu Z, Hao X, Li M, Luo H
International journal of molecular sciences 2022 Aug 28;23(17)
International journal of molecular sciences 2022 Aug 28;23(17)
Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells.
Wang B, Wang M, Jia S, Li T, Yang M, Ge F
Journal of proteome research 2022 Apr 1;21(4):1137-1152
Journal of proteome research 2022 Apr 1;21(4):1137-1152
piR-121380 Is Involved in Cryo-Capacitation and Regulates Post-Thawed Boar Sperm Quality Through Phosphorylation of ERK2 via Targeting PTPN7.
Wang Y, Yuan X, Ali MA, Qin Z, Zhang Y, Zeng C
Frontiers in cell and developmental biology 2021;9:792994
Frontiers in cell and developmental biology 2021;9:792994
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Yang X, Jin J, Yang J, Zhou L, Mi S, Qi G
Genetics and molecular biology 2021;44(4):e20210058
Genetics and molecular biology 2021;44(4):e20210058
Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology.
Zhan L, Pu J, Hu Y, Xu P, Liang W, Ji C
BioMed research international 2021;2021:6621682
BioMed research international 2021;2021:6621682
Comparative Efficacy of Haizao Yuhu Decoction Composed of Different Varieties of Glycyrrhiza in Goiter Rats.
Chen F, Li N, Xiu L, Liu H, Chen S, He C, Fan A, Yu X, Wang X, Ge C, Huo M, He J, Zhong G
Evidence-based complementary and alternative medicine : eCAM 2021;2021:4343239
Evidence-based complementary and alternative medicine : eCAM 2021;2021:4343239
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
Drug design, development and therapy 2021;15:3207-3221
Drug design, development and therapy 2021;15:3207-3221
Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer.
Li H, Yang W, Zhang M, He T, Zhou F, G Herman J, Hu L, Guo M
Epigenomics 2021 Sep;13(17):1403-1419
Epigenomics 2021 Sep;13(17):1403-1419
Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway.
Jia Z, Yang J, Cao Z, Zhao J, Zhang J, Lu Y, Chu L, Zhang S, Chen Y, Pei L
Behavioural brain research 2021 Sep 24;414:113463
Behavioural brain research 2021 Sep 24;414:113463
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine.
Zhang X, You L, Zhang X, Wang F, Wang Y, Zhou J, Liu C, Qu F
Chinese medicine 2021 Oct 2;16(1):97
Chinese medicine 2021 Oct 2;16(1):97
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.
Wu C, Huang ZH, Meng ZQ, Fan XT, Lu S, Tan YY, You LM, Huang JQ, Stalin A, Ye PZ, Wu ZS, Zhang JY, Liu XK, Zhou W, Zhang XM, Wu JR
Chinese medicine 2021 Nov 22;16(1):121
Chinese medicine 2021 Nov 22;16(1):121
1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways.
Tang JJ, Wang MR, Dong S, Huang LF, He QR, Gao JM
European journal of medicinal chemistry 2021 Nov 15;224:113713
European journal of medicinal chemistry 2021 Nov 15;224:113713
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.
Wang X, Gong Q, Song C, Fang J, Yang Y, Liang X, Huang X, Liu J
Toxicology and applied pharmacology 2021 May 1;418:115484
Toxicology and applied pharmacology 2021 May 1;418:115484
Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling.
Zhu K, Bai H, Mu M, Xue Y, Duan Z
FEBS open bio 2021 Jul;11(7):2041-2049
FEBS open bio 2021 Jul;11(7):2041-2049
MiR-1307-5p targeting TRAF3 upregulates the MAPK/NF-κB pathway and promotes lung adenocarcinoma proliferation.
Du X, Wang S, Liu X, He T, Lin X, Wu S, Wang D, Li J, Huang W, Yang H
Cancer cell international 2020;20:502
Cancer cell international 2020;20:502
Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression.
Jiang W, Li H, Liu X, Zhang J, Zhang W, Li T, Liu L, Yu X
Theranostics 2020;10(25):11507-11519
Theranostics 2020;10(25):11507-11519
Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.
Wang L, Zhan J, Huang W
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)
Resveratrol-loaded biopolymer core-shell nanoparticles: bioavailability and anti-inflammatory effects.
Liu Y, Liang X, Zou Y, Peng Y, McClements DJ, Hu K
Food & function 2020 May 1;11(5):4014-4025
Food & function 2020 May 1;11(5):4014-4025
Inhibiting PKCβ2 protects HK-2 cells against meglumine diatrizoate and AGEs-induced apoptosis and autophagy.
Jiang W, Zhao W, Ye F, Huang S, Wu Y, Chen H, Zhou R, Fu G
Annals of translational medicine 2020 Mar;8(6):293
Annals of translational medicine 2020 Mar;8(6):293
Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts.
Zhou D, Yang WK, Zhang YF, Xie JH, Ma L, Yang HD, Li Y, Xie P
Chinese journal of natural medicines 2020 Jun;18(6):436-445
Chinese journal of natural medicines 2020 Jun;18(6):436-445
Hfm1 participates in Golgi-associated spindle assembly and division in mouse oocyte meiosis.
Wang H, Zhong C, Yang R, Yin Y, Tan R, Gao L, Gao C, Cui Y, Pu D, Wu J
Cell death & disease 2020 Jun 30;11(6):490
Cell death & disease 2020 Jun 30;11(6):490
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Shopit A, Niu M, Wang H, Tang Z, Li X, Tesfaldet T, Ai J, Ahmad N, Al-Azab M, Tang Z
Life sciences 2020 Feb 1;242:117248
Life sciences 2020 Feb 1;242:117248
Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice.
Wang S, Chen Q, Zhang Y, Zheng F, Xue T, Ge X, Ma R, Li X, Wu R, Liang K, Qian Z, Ge Y, Ma J, Yao B
Reproductive toxicology (Elmsford, N.Y.) 2020 Dec;98:233-241
Reproductive toxicology (Elmsford, N.Y.) 2020 Dec;98:233-241
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Zhang Y, Sun J, Dong Y, Shen X, Zhang Z
Journal of biochemical and molecular toxicology 2020 Dec 16;:e22680
Journal of biochemical and molecular toxicology 2020 Dec 16;:e22680
MiR-96-5p promotes breast cancer migration by activating MEK/ERK signaling.
Qin WY, Feng SC, Sun YQ, Jiang GQ
The journal of gene medicine 2020 Aug;22(8):e3188
The journal of gene medicine 2020 Aug;22(8):e3188
PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation.
Lv JM, Chen L, Gao Y, Huang H, Pan XW, Liu X, Chen M, Qu FJ, Li L, Wang JK, Cui XG, Xu DF
OncoTargets and therapy 2018;11:5797-5809
OncoTargets and therapy 2018;11:5797-5809
Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling.
Wu Y, Wang M, Zhang K, Li Y, Xu M, Tang S, Qu X, Li C
Biochemical and biophysical research communications 2018 Sep 5;503(2):737-743
Biochemical and biophysical research communications 2018 Sep 5;503(2):737-743
Soluble epoxide hydrolase inhibition alleviated cognitive impairments via NRG1/ErbB4 signaling after chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis in mice.
Hao J, Chen Y, Yao E, Liu X
Brain research 2018 Nov 15;1699:89-99
Brain research 2018 Nov 15;1699:89-99
Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.
Zhao B, Liu L, Mao J, Liu K, Fan W, Liu J, Zhang Z, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1036-1044
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1036-1044
Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.
Liu GY, Shi JX, Shi SL, Liu F, Rui G, Li X, Gao LB, Deng XL, Li QF
Journal of cellular biochemistry 2017 Dec;118(12):4697-4707
Journal of cellular biochemistry 2017 Dec;118(12):4697-4707
Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.
Wang H, Cai J, Du S, Guo Z, Xin B, Wang J, Wei W, Shen X
Cell biochemistry and function 2017 Aug;35(6):315-326
Cell biochemistry and function 2017 Aug;35(6):315-326
HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth.
Lu Y, Wang Y, Zhang M, Liu L, Li F, Zhang J, Ye M, Zhao H, Zhao J, Yan B, Yang A, Zhang R, Li X, Ren X
Oncotarget 2016 Apr 26;7(17):23594-607
Oncotarget 2016 Apr 26;7(17):23594-607
SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway.
Li XL, Chen XQ, Zhang MN, Chen N, Nie L, Xu M, Gong J, Shen PF, Su ZZ, Weng X, Tan JY, Zhao T, Zeng H, Zhou Q
International journal of clinical and experimental pathology 2015;8(4):3871-81
International journal of clinical and experimental pathology 2015;8(4):3871-81
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y
International journal of clinical and experimental pathology 2015;8(12):15836-44
International journal of clinical and experimental pathology 2015;8(12):15836-44
Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca²⁺-dependent ERK signaling pathway.
Li X, Zhao H, Wang Q, Liang H, Jiang X
Molecular medicine reports 2015 May;11(5):3746-52
Molecular medicine reports 2015 May;11(5):3746-52
Polychlorinated biphenyl quinone induces endothelial barrier dysregulation by setting the cross talk between VE-cadherin, focal adhesion, and MAPK signaling.
Zhang P, Feng S, Bai H, Zeng P, Chen F, Wu C, Peng Y, Zhang Q, Zhang Q, Ye Q, Xue Q, Xu X, Song E, Song Y
American journal of physiology. Heart and circulatory physiology 2015 May 15;308(10):H1205-14
American journal of physiology. Heart and circulatory physiology 2015 May 15;308(10):H1205-14
Tenascin-C induces resistance to apoptosis in pancreatic cancer cell through activation of ERK/NF-κB pathway.
Shi M, He X, Wei W, Wang J, Zhang T, Shen X
Apoptosis : an international journal on programmed cell death 2015 Jun;20(6):843-57
Apoptosis : an international journal on programmed cell death 2015 Jun;20(6):843-57
Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions.
Liu C, Liu Y, Xu XX, Wu H, Xie HG, Chen L, Lu T, Yang L, Guo X, Sun GW, Wang W, Ma XJ, He X
Experimental cell research 2015 Jan 1;330(1):123-34
Experimental cell research 2015 Jan 1;330(1):123-34
13-acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression.
Su CC, Chen JY, Din ZH, Su JH, Yang ZY, Chen YJ, Wang RY, Wu YJ
Marine drugs 2014 Oct 23;12(10):5295-315
Marine drugs 2014 Oct 23;12(10):5295-315
MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway.
Shi L, Zhang S, Wu H, Zhang L, Dai X, Hu J, Xue J, Liu T, Liang Y, Wu G
PloS one 2013;8(10):e78344
PloS one 2013;8(10):e78344
Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway.
Dai XF, Ding J, Zhang RG, Ren JH, Ma CM, Wu G
International journal of radiation biology 2013 Sep;89(9):724-31
International journal of radiation biology 2013 Sep;89(9):724-31
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A375 cells were subjected to SDS PAGE followed by western blot with 11257-1-AP(ERK1 antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 11257-1-AP(ERK1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ERK1/2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ERK1/2. This antibody recognizes human, mouse antigen. The ERK1/2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
