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- References [688]
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- Product number
- 11257-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11257-1-AP, RRID:AB_2139822
- Product name
- ERK1/2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ERK1/2 antibody (Cat. #11257-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SENP6 Restrains NLRP3 Inflammasome Activation via DeSUMOylation-Driven K48-Linked Ubiquitination of NLRP3 in Acute Lung Injury.
Lymph Node Metastasis-Associated Spatiotemporal Mapping of the TFF3-Linked Niche in Breast Cancer: Integrating Radiogenomic Signatures with Immune-Ecosystem Remodeling.
Triptonide-mediated PTGS2 Inhibition Induces Autophagic Cell Death to Suppress the Progression of Triple-negative Breast Cancer and Epithelial Ovarian Cancer.
DJ-1 alleviates high glucose-induced podocyte injury via activating ERK1/2 signaling.
Research on the Inhibition of Cancer Cell Metastasis by Graphene Oxide Suppresses the Translation of the Snail mRNA.
Wuji Wan ameliorates ulcerative colitis by restoring impaired membrane transport.
Research on the correlation and potential mechanism of PKCδ expression with efficacy and prognosis in diffuse large B-cell lymphoma.
PLOD2 Promotes Cutaneous Squamous Cell Carcinoma Progression in Association With STAT3-Related ERK and AKT Pathways.
Farnesol Targets the GSTP1/MAPK Axis to Inhibit Trauma-Induced Tendon Heterotopic Ossification.
Taohong Siwu decoction and its components regulate the M1/M2 polarization of macrophages to alleviate inflammatory injury in sepsis via the RAGE.
Isoliquiritigenin restores bone homeostasis in osteoporotic rats by enhancing BMSCs osteogenesis via ERK1/2-mTOR-HIF-1α-glycolytic axis and suppressing inflammation.
Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense.
Mechanism of biomimetic virus-like nanoparticles in triggering immune response elucidated by proteomics.
Reversibly unlocking the blood-brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide.
Aloe-emodin inhibits p38 MAPK pathway in Alzheimer's disease treatment: a network pharmacology and experimental verification.
Deficiency of interleukin-40 prevents intestinal damage in experimental necrotizing enterocolitis by inhibiting NETosis.
Red Blood Cell-Derived Exosomes Deliver Complement C5 to Exacerbate Neuroinflammation and Neuronal Injury after Intracerebral Hemorrhage.
PRMT1 facilitates the tumorigenesis of chronic lymphocytic leukemia by regulating methylation of MAST1.
Multi-omics and network pharmacology reveal the mechanisms of Scutellaria barbata D.Don and Scleromitrion diffusum (Willd.) R.J.Wang against pancreatic cancer.
A tumor-resident bacterium promotes cervical cancer progression through lysoPC-mediated c-Jun/c-Fos activation.
DSCAML1+ extracellular vesicles revealed by single-vesicle proteomics as a novel biomarker and therapeutic target in myocardial infarction.
The enhanced osteogenic differentiation of human periodontal ligament stem cells and M2 polarization of macrophages may be mediated by EphB4/ephrinB2 signaling pathway: a study of their direct co-culture.
Exposure to 2-chlorohydroquinone induces systemic vascular disorders and increases the risk of cerebral hemorrhage in zebrafish larvae.
PKA and PKC signaling pathways mediate vitamin D₃-regulated intestinal phosphorus absorption in broiler chickens.
UBQLN1 Inhibition reduces MASH progression through downregulating SIKE/p38 MAPK pathway in hepatocyte.
Aspartame exacerbates cerebral ischemia-reperfusion injury via mitochondrial dysfunction and ERK/CREB1 pathway suppression.
Phycocyanin-functionalized selenium nanoparticles attenuate osteoarthritis through ferroptosis suppression and modulation of the MAPK pathway.
Hepatic cavernous hemangioma decellularized extracellular matrix/GelMA composite hydrogel promotes angiogenesis via the ITGA9-FAK-ERK1/2 axis.
A natural product-hybridization approach toward anticancer drug discovery: synthesis and antitumor evaluation of CTBC6, designed from sulforaphane and magnolol.
ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway.
Neferine ameliorates psoriasis through inducing oxidative stress-mediated keratinocyte apoptosis and suppressing inflammatory response via the Keap1-Nrf2 pathway.
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
HOMER3 drives oral squamous cell carcinoma progression through TRPV6 calcium influx and TUBB3 microtubule stabilization.
Exploring the Potential Targets and Molecular Mechanisms of Selenomethionine to Attenuate Acute Kidney Injury Based on Network Pharmacology, Molecular Simulation Technology and Animal Experiments.
Targeting aldose reductase in pulmonary fibrosis: Blocking de novo fatty acid synthesis halts pro-fibrotic M2 polarization.
Immunological activity of peach pectins: Insights from cells to animals.
Effects of repetitive transcranial magnetic stimulation on apoptosis and MAPK/PI3K-AKT signaling pathways in rats with spinal cord injury.
Pyraclostrobin induces brain oxidative stress, apoptosis and inflammation through mitochondrial phosphorylation-induced ROS activation of the p38 MAPK pathway.
Hydrogen sulfide promotes proliferation and regeneration of human cerebral microvascular endothelial cells via the sonic hedgehog signaling pathway.
Echinacoside Improves Pulmonary Vascular Remodeling by Regulating the L- and T-Type Ca(2+) Channels in the Prevention and Treatment of Pulmonary Hypertension.
Lobetyolin alleviates microglial inflammation by activating CK2α/Opa1-mediated mitochondrial fusion in ischemic stroke.
Moutan cortex ameliorates perimenopausal syndrome by regulating the KISS1R-ERK1/2-GnRH signaling pathway: Evidence from serum pharmacochemistry and network pharmacology.
Dexmedetomidine alleviates sepsis-associated acute kidney injury by inhibiting renal tubular ferroptosis via JNK/MAPK-LCN2 pathway.
HUVEC-derived exosomes alleviate lipopolysaccharide-induced acute lung injury inflammation by restoring the balance of mitochondrial fusion and division.
Vasicine Attenuates Allergic Asthma by Suppressing Mast Cell Degranulation and Th2 Inflammation via Modulation of the FcεRI/Lyn + Syk/MAPK Pathway.
Zhigancao decoction alleviates Parkinson's disease via inhibiting TNF/NF-κB and Ras/ERK-mediated neuroinflammation and apoptosis.
The mechanism of indigo naturalis and its active ingredients against ulcerative colitis.
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in hepatocellular carcinoma cells.
Promoter Methylation of WIF1 is Involved in IL-17-Induced Chondrocyte Inflammatory Injury and Matrix Degradation via Promoting Wnt5a/MAPK-JNK Signaling.
STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma.
Cycloastragenol Regulates Mitochondrial Homeostasis-Mediated Renal Tubular Injury to Ameliorate Diabetic Kidney Disease by Directly Targeting ERK to Modulate TFEB.
Modulation of endothelial-to-mesenchymal transition via NRP-1 targeting with melittin attenuates pulmonary fibrosis.
Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents.
Biomimetic Multilayered Gas-Foaming Scaffold with Sustained bFGF Delivery for Annulus Fibrosus Regeneration.
Ursodeoxycholic acid alleviates α-Casein-induced cow's milk protein allergy via the TGR5/NF-κB signaling pathway.
Exploration of borneol essential oil function in the treatment of Alzheimer's disease based on network pharmacology and experimental validation.
Anti-inflammatory effects and mechanisms of Podophyllum hexandrum rhizomes and fruits in a chronic pelvic inflammatory disease rat model.
Role of CTGF-LRP1 in impaired healing of cesarean section incisions.
Self-Assembled Rg3/Naringenin Nanoparticles for Targeted Brain Delivery: A Promising Therapeutic Approach for Early Alzheimer's Disease.
AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.
The P7 peptide antagonizes bFGF-induced malignant behaviors of ovarian cancer by inhibiting MEK/ERK signaling pathway.
A novel AGTPBP1-ERK/MYLK network mediates pancreatic cancer progression.
U0126 induces osteoclast differentiation via the p38-NFATc-1 signaling pathway.
Sequential delivery of sinigrin and dabigatran by an in situ self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration.
Recombinant Filaggrin-2 microneedles reverse androgenetic alopecia by rescuing mitochondrial dysfunction in dermal papilla cells.
High-throughput screening of EGFR/Ca(2+) signaling modulators in cardiac hypertrophy using a tetrahedral DNA nanostructure-based hESC platform.
Structure-Based Discovery of Novel, Highly Potent VEGFR2 Inhibitors with a Naphthalene Scaffold against a Broad Range of Solid Tumors.
Design, synthesis, and investigation of anti-Alzheimer's activity and molecular mechanisms of phosphatidylserine derivatives.
Brucea Javanica Oil Attenuates Osteosarcoma Progression by Reprogramming Tumor-associated Macrophages via Inhibiting PI3K/AKT Pathway.
Bovine serum albumin-coated metal-phenolic nanoplatform for atherosclerosis therapy via targeted delivery and inhibition of vascular smooth muscle cells proliferation.
Network Toxicology and In Vivo Studies Reveal the Toxicity and Mechanisms of Tributyl Citrate Carried by Microplastics in Promoting Colitis-to-Tumorigenesis Transformation.
Panax notoginseng saponins enhance osteogenesis-angiogenesis coupling to ameliorate osteoporosis combined with intervertebral disc degeneration.
CuET inhibits Ewing sarcoma of bone progression through modulation of the ESM1-MAPK/ERK signaling axis.
Study of the role of transmembrane emp24 domain-containing protein 2 in oral squamous cell carcinoma.
MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells.
Succinate Facilitates CD4(+) T Cell Infiltration and CCL1 Production to Promote Myofibroblast Activation and Renal Fibrosis in UUO Mice.
Naoxintong Is Involved in the Coagulation Regulation of Warfarin Through the MAPK Pathway.
Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway.
Silencing ATF3 mediates mitochondrial homeostasis and improves ischemic stroke through regulating the MAPK signaling pathway.
Network Pharmacology, Experimental Validation Explored Kakkalide to Ameliorate Endothelial Cell Dysfunction and Inflammatory Response.
CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway.
Extracellular vesicles-miR-205-5p inhibits lymphatic metastasis in pancreatic cancer through diffusely downregulating VEGFA.
Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models.
Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer.
Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma.
ATP1B3 may promote glioma proliferation and migration through MAPK/NF-KB signaling pathway.
Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone.
Zirconia/dental pulp stem cell composite scaffolds repair osteogenic defect via regulating macrophages.
Fibroblast growth factor 19 regulates polycystic ovary syndrome progression via FGFR4-ERK-NRF2 pathway.
Suyin Detoxification Prescription Regulates the Klotho and ERK/NF-κB Signaling Pathways to Alleviate Renal Injury.
TUFT1 Modulates Cell Proliferation, Migration, Invasion, Stemness and EGFR Signaling in Cervical Cancer through Interacting with and Targeting ATF1.
Alpha-enolase promotes progression of acute myeloid leukemia via MAPK/ERK signaling pathway.
Up-regulation of NGEF via the BRAF(V600E) /ERK/AP1 pathway enhances invasion and migration abilities of BRAF(V600E)-mutant thyroid cancer.
Mycobacterium tuberculosis Rv2521 promotes ferroptosis-dependent pathogenicity by inhibiting NF-κB activation.
Ovotransferrin ameliorated intestinal barrier dysfunction in DSS-induced ulcerative colitis mice via inhibition of PI3K-Akt/MAPK signaling pathways and modulation of tissue metabolism.
TMI, an isoflavone from the fruits of Ficus altissima Blume, overcomes K562/ADR leukemia cells resistance by targeting Nrf2.
Naringenin: A potential therapeutic agent for modulating angiogenesis and immune response in hepatocellular carcinoma.
Peroxisome Proliferator-Activated Receptor Gamma (PPARγ)-targeted Gel/Mg/Lip@Gigantol nanoplatform attenuates skin barrier disruption-associated aging in mice via NLRP3 suppression.
Uncovering key anti-inflammatory constituents and mechanism of Wuwei Xiaodu Decoction by a combined strategy of phytochemistry, AIDD, network pharmacology, and in vitro and in vivo assay.
Comparison of Quercetin and Isoquercitrin's Anti-Heart Failure Activity via MAPK Inflammatory Pathway and Caspase Apoptosis Pathway.
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics.
Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis.
SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer.
Kuwanon A Targeted YWHAB in Hepatocellular Carcinoma Cells to Inhibit the Raf/MEK/ERK Signaling Pathway.
Bisphenol A promotes OSCC progression via GABBR1-mediated MAPK signaling and macrophage polarization: A network toxicology based study.
Bushen Jiangu decoction alleviates osteoporosis by inhibiting MMP2 expression and activation of the MAPK pathway in vitro.
Self-propelled gas nanomotor-integrated microneedles for melanoma therapy: Dual-action in situ eradication and metastatic suppression.
Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice.
Critical role of the β isoform of protein kinase C (PKCβ) in angiotensin II-induced oxidative stress in vascular smooth muscle cells.
Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinoma.
TSN Disrupts Fanconi Anemia Pathway Activation Through JAK/STAT1-Mediated Transcriptional Repression of FA Core Subunits in Bladder Cancer.
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway.
Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
Non canonical BRCA1 promotes cell survival via modulating PARP13-mediated SEC61G mRNA decay.
OTSSP167 suppresses TNBC brain metastasis via ROS-driven P38/JNK and FAK/ERK pathways.
Trem2-MICAL1-P-ERK Axis in Macrophages Confers Protection Against Toxoplasma gondii-Induced Adverse Pregnancy Outcomes.
The SP1-SuperEnhancer-SPHK1 Axis Mediates Niraparib Resistance in TNBC.
Preconception paternal exposure to zearalenone impairs male fertility and IVF embryo survival in mice.
PTPN2 acts as a tumor suppressor and therapeutic target in ovarian cancer.
GPR30-mediated the MEK/ERK signaling pathway promotes porcine oocyte maturation and development.
Bacteroides vulgatus alleviates heart failure via butyric acid-TGF-β1/MAPK pathway.
PDLIM4 drives gastric cancer malignant progression and cisplatin resistance by inhibiting HSP70 ubiquitination and degradation via competitive interaction with STUB1.
Crinis Carbonisatus-Derived Carbon Dot Suspension Alleviates Temporal Lobe Epilepsy.
Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.
Bispecific aptamers target thyrotropin receptor (TSHR) and insulin growth factor-1 receptor (IGF-1R) for the improvement of orbital fibroblasts activation in the treatment of thyroid-associated ophthalmopathy.
The β-glucan from Lentinus alleviates UVB-induced dermal fibroblasts senescence and skin photoaging.
Polystyrene nanoplastics impair endometrial decidualization via cell cycle arrest and JNK-MAPK pathway-mediated oxidative stress in early pregnant mice.
SIN1 facilitates glioma progression and is associated with the KRAS/ERK pathway.
Exploration of new azole derivatives containing ethanolamine moiety as anti-UC agents by inhibiting NF-κB/MAPK pathways.
Scutellarin Protects Retinal Ganglion Cells in Glaucoma by Targeting the Hsp90aa1-MAPK Pathway to Inhibit Apoptosis.
Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression.
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Integrated analysis of Corylin from Psoralea Corylifolia inhibiting osteoporosis via MAPK pathway.
MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics.
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.
FGF21 Exhibits Neuroprotective Effects by Promoting 5-HT(1A)R-FGFR1 Heteroreceptor Complexes and Triggering MEK(1/2)-ERK(1/2) Signaling Pathway.
Oleracein E Rejuvenates Senescent Hippocampal NSCs by Inhibiting the ERK1/2-mTOR Axis to Improve Cognitive Dysfunction in Vascular Dementia.
Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure.
Lipocalin 2 Facilitates the Initial Compromise of the Blood-Brain Barrier Integrity in Chronic Cerebral Hypoperfusion.
An exploration on the involvement of the methyltransferase like 3-m(6)A‑zinc finger MYM-type containing 1 axis in the progression of liver hepatocellular carcinoma.
Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells.
Lentinan alleviates angiotensin II-induced myocardial remodeling through LMP7-SOCS3 signaling.
The Potential Hepatocyte Differentiation Targets and MSC Proliferation by FH1.
Hypoglycemic effect of dietary fibers from Moringa oleifera leaves: In vitro and in vivo studies.
10-Hydroxydec-2-enoic acid reduces vascular smooth muscle cell inflammation via interacting with Toll-like receptor 4.
Rilmenidine attenuates intracerebral hemorrhage by regulating autophagy flux and apoptosis via the HO-1/Fe(2+)/ERK pathway.
Melatonin Promotes Osteogenic Differentiation of Rat Adipose-Derived Stem Cells via the p38/MAPK Signaling Pathway.
Mineralocorticoid receptor antagonism attenuates arteriovenous fistula stenosis by modulating the phenotype of vascular smooth muscle cells.
ShenJiaoLingCao decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism.
Mechanism of the Proprietary Chinese Medicine "JiuLiWan" to Treat Ulcerative Colitis Revealed by Network Pharmacology, Molecular Docking, and Experimental Verification In Vitro.
LncRNA NEAT1 participates in diminished ovarian reserve by affecting granulosa cell apoptosis and estradiol synthesis via the miR-204-5p/ESR1 axis.
Basal and AT2 cells promote IPF-lung cancer co-occurrence via EMT: Single-cell analysis.
Modified weiling decoction inhibited excessive autophagy via AKT/mTOR/ULK1 pathway to alleviate T2DM: Integrating network pharmacology and experimental validation.
LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway.
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells.
The protective effect and potential mechanism of Zanthoxylum bungeanum Maxim. on atherosclerosis.
ELF5 gene promotes milk lipid synthesis in goat mammary epithelial cells by transcriptomic analysis.
Exosomal integrin alpha 3 promotes epithelial ovarian cancer cell migration via the S100A7/p-ERK signaling pathway.
Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis.
FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD(+) acute myeloid leukemia.
Ginsenoside 1 mitigates postoperative cognitive dysfunction by enhancing microglial Aβ clearance through the endo-lysosomal pathway.
Identification of therapeutic targets and immune landscape in glioblastoma through crosstalk with glioma-associated mesenchymal stem cells.
Integration analysis of miRNA-mRNA uncovers the mechanisms of ochratoxin A-induced hepatotoxicity.
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes.
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway.
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
Exosomes derived from myelodysplastic syndromes cells induce IL-1β production from macrophages to promote disease progress.
The key active ingredients identification and pharmacological mechanism investigation of extract of ethyl acetate from Er Miao San aganist rheumatoid arthritis.
ULBP2 promotes progression of head and neck squamous cell carcinoma by modulating MAPK signaling pathway.
Luteolin ameliorates kainic acid-induced seizure by modulating GADD45B and reducing oxidative stress in hippocampal neurons.
LRP1 regulates asthmatic airway smooth muscle proliferation through FGF2/ERK signaling.
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
Resveratrol exerts antiviral activity against pseudorabies virus through regulation of the OPN-ERK/JNK-IL-1β signaling axis.
Polystyrene nanoplastics aggravate house dust mite induced allergic airway inflammation through EGFR/ERK-dependent lung epithelial barrier dysfunction.
Sea Cucumber Fucoidan Inhibits Helicobacter pylori Gastritis via MAPK/NF-κB Signaling and Gut Microbiota Modulation.
PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma.
CDC42 Regulates the ERK Pathway to Improve Oxygen‒Glucose Deprivation/Reoxygenation-Induced Neural Oxidative Stress and Apoptosis.
Asperosaponin VI Promotes Osteoporotic Fracture Healing by Targeting Piezo1 to Enhance the Coupling of LEPR(+) BMSCs and PODXL(+) ECs.
JNK signaling dominance in hyperthermia.
Different neutrophil extracellular trap related Ewing sarcoma subtypes exhibit distinct prognosis, and immune microenvironment characteristics.
Multi-omics study reveals gut microbiota dysbiosis and tryptophan metabolism alterations in GH-PitNET progression.
Annexin A2: regulating glioma's fate and a potential therapeutic target.
Discovery of a Novel EGFR PROTAC Degrader against C797S Resistance Mutation with Potent Antitumor Efficacy in NSCLC Treatment.
Suppression of the HSP90-HIF1α pathway with SNX2112-encapsulated nano-micelles for effective triple-negative breast cancer photothermal combined photodynamic therapy.
Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development.
Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1.
FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise.
Non-canonical activation of MAPK signaling by the lncRNA ASH1L-AS1-encoded microprotein APPLE through inhibition of PP1/PP2A-mediated ERK1/2 dephosphorylation in hepatocellular carcinoma.
Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models.
Hydrogel system with growth cone-targeted hydroxyapatite nanorods: Regulating calcium signals for peripheral nerve injury repair.
Harmine exerts anticancer effects through the ROS/p38 axis to induce autophagy and apoptosis in osteosarcoma.
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation.
Oxymatrine antagonises oxidative stress and apoptosis in Nemopilema nomurai toxin-induced cardiotoxicity by inhibiting mitogen-activated protein kinase.
Role of semaphorin7A in epithelial-mesenchymal transition and proliferative vitreoretinopathy.
ARL11 knockdown alleviates spinal cord injury by inhibiting neuroinflammation and M1 activation of microglia in mice.
Vitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR.
Sappanone A alleviates metabolic dysfunction-associated steatohepatitis by decreasing hepatocyte lipotoxicity via targeting Mup3 in mice.
Pimpinellin mitigates DSS-induced ulcerative colitis in mice by reducing inflammation and regulating gut microbiota.
Toosendanin alleviates acute lung injury by reducing pulmonary vascular barrier dysfunction mediated by endoplasmic reticulum stress through mTOR.
Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice.
Halofuginone induces ERK phosphorylation and synergizes with trametinib in gastric cancer cells.
Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro.
Zinc proteinate alleviates thermal stress-induced damage to broiler jejunal organoid integrity and barrier function possibly by promoting cell proliferation via GPR39/PLCβ1-mediated PI3K/AKT and MAPK signaling pathways.
Revealing the molecular mechanism of baohuoside I for the treatment of breast cancer based on network pharmacology and molecular docking.
PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response.
Antitumor Effects of Tryptanthrin on Colorectal Cancer by Regulating the Mitogen-Activated Protein Kinase Signaling Pathway and Targeting Topo I and IDO1.
TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3.
DNA-Dependent Protein Kinase Catalytic Subunit Prevents Ferroptosis in Retinal Pigment Epithelial Cells.
Zinc-induced photocrosslinked konjac glucomannan/glycyrrhizic acid hydrogel promotes skin wound healing in diabetic mice through immune regulation.
Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells.
Mechanism of dihydroartemisinin in the treatment of ischaemia/reperfusion-induced acute kidney injury via network pharmacology, molecular dynamics simulation and experiments.
CAVIN2 attenuates ventilator-induced lung injury in rats by MAPK/ERK1/2 signaling pathway.
Extracellular vesicles derived from bone marrow mesenchymal stem cells ameliorate chronic liver damage via microRNA-136-5p.
Influence of the ERK/CHGB pathway in breast cancer progression under chronic stress.
Design and Synthesis of Novel MEK Inhibitors for the Treatment of Solid Tumors.
HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway.
SJB2-043, a USP1 Inhibitor, Suppresses A549 Cell Proliferation, Migration, and EMT via Modulation of PI3K/AKT/mTOR, MAPK, and Wnt Signaling Pathways.
Melatonin-pretreated mesenchymal stem cell-derived exosomes alleviate cavernous fibrosis in a rat model of nerve injury-induced erectile dysfunction via miR-145-5p/TGF-β/Smad axis.
Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury.
ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway.
KRAS(G12D)-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC.
S100A12 triggers NETosis to aggravate myocardial infarction injury via the Annexin A5-calcium axis.
Discovery of novel capsaicin analogs as TRPV1 inhibitors for the treatment of idiopathic pulmonary fibrosis.
Arthrocolin B Impairs Adipogenesis via Delaying Cell Cycle Progression During the Mitotic Clonal Expansion Period.
RAB3GAP2 silencing alleviates oxidative stress in cataracts by enhancing Mfn2-mediated mitochondrial autophagy by activating JNK/STAT3.
Structural characterisation of a polysaccharide from Sanghuangporus vaninii and its synergistic anti-hepatocellular carcinoma activity in combination with sorafenib.
RhoE downregulation leads to enhanced cholesterol biosynthesis and sorafenib resistance in hepatocellular carcinoma.
Co-fermentation of honeysuckle-Cassia seeds by Lactobacillus acidophilus and Bacillus subtilis: A new approach to attenuate alcohol-induced acute gastric mucosal damage and modulate immune response.
UBE2M inhibits neoplastic cell proliferation via MKK7-JNK-EGR1 axis in melanoma.
Nicotine exacerbates MASH via inducing intestinal dysbiosis and barrier dysfunction.
The NAWG combinatorial strategy activates MAPK signaling to restore extracellular matrix architecture in aging skin.
CYP8B1 inhibits hepatocellular carcinoma progression by repressing PAK4 transcription through inhibition of nuclear translocation of u-STAT1.
Tubuloside B alleviates con A-induced acute liver injury by inhibiting the IL-23/JAK2/STAT3 signaling pathway hyperactivation during Th17 cell differentiation.
Liensinine can improve vascular remodeling in hypertension through the ferroptosis-related TLR4 inflammatory pathway.
Promoting astrocyte-neuron triiodothyronine shuttling attenuates brain damage in neonatal hypoxic-ischemic encephalopathy.
Hsa_circ_0000437 promotes the progression of rheumatic valvular heart disease by activating the mitogen-activated protein kinase signaling pathways after sponging let-7f-5p and targeting RAS-like proto-oncogene B.
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.
Anti-Inflammatory Effect of a Polysaccharide Derived from Artocarpus heterophyllus Lam. Pulp on Lipopolysaccharide-Stimulated RAW264.7 Macrophages Through Inhibiting MAPK/ERK Signaling Pathway.
Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia.
BMAL1 downregulation drives PANoptosis and the osteogenic differentiation impairment of PDLSCs by ERK/AP-1 signaling pathway.
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
Microneedles loaded with l-arginine-modified puerarin-derived carbon nanoparticles improved treatment of diabetic wound via photothermal and nitric oxide-based gas therapy.
Zika virus capsid protein impairs neural differentiation.
Biomimetic Nanoplatform Integrating CeO₂ Nanozymes and Anti-Inflammatory Peptides for Osteoarthritis Therapy.
The involvement of Rab5 in regulating haematopoiesis in the Chinese mitten crab Eriocheir sinensis.
Biliverdin alleviates cerebral ischemia-reperfusion injury by regulating the P4hb/MAPK/mTOR pathway to inhibit autophagy.
G-protein coupled receptor 183 (GPR183) inhibits visceral metastasis of non-small cell lung cancer.
Identification of IQGAP3 prognostic potential and involvement in immune cell infiltration in LUAD.
Promotion of the invasion and metastasis of breast cancer by B7-H3 through CCR5High tumor-associated macrophages.
DDX18 promotes growth and metastasis of hepatocellular carcinoma via activating EMT and MAPK signaling.
MED10 as a Novel Oncogenic Driver in HCC: Promoting Cell Cycle Progression and Proliferation Through RAF1 Activation.
Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.
VDR Decrease Enhances the Efficacy of 1,25-Dihydroxyvitamin D3 Inhibiting Gefitinib Resistance by Regulating EGFR/FASN Loop in NSCLC Cells.
Baicalin Alleviates ADAM17/EGFR Axis-Induced Peritonitis in Weaned Piglets Infected by Glaesserella parasuis.
Single-cell transcriptome analysis identifies MIF as a novel tumor-associated neutrophil marker for pancreatic ductal adenocarcinoma.
Membrane protein CRISPR screen identifies RPSA as an essential host factor for porcine epidemic diarrhea virus replication.
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
Protein arginine methyltransferase 1 stimulates basal cell proliferation and migration to maintain corneal epithelial homeostasis.
Chondroitin sulfate protects against synaptic impairment caused by fluorosis through the Erk1/2-MMP-9 signaling pathway.
Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.
PRMT5 Inhibition Enhances Therapeutic Efficacy of Cisplatin via Mediating miR-29b-3p-Mcl-1 Expression in Lung Adenocarcinoma.
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Mycoplasma ovipnuemoniae impairs the immune response of sheep and suppresses neutrophil function by inhibiting S100A9.
hUC-MSCs Prevent Acute High-Altitude Injury through Apoe/Pdgf-b/p-Erk1/2 Axis in Mice.
TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney.
Brusatol inhibits malignant phenotypes and lipid metabolism of osteosarcoma cells by regulating PI3K/AKT and MAPK pathways.
Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non-Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production.
Berberine Alleviates 1-Methyl-3-Nitro-1-Nitrosoguanidine- Induced Chronic Atrophic Gastritis in Rats.
Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling.
Alleviation of obesity cardiomyopathy by Fisetin through the inhibition of NF-κB/MAPK signaling.
Gαq/11 Signaling Modulates Fibroblast Growth Factor 23 Production and Contributes to Acute Kidney Injury.
Luteolin 7-Glucuronide in Artemisia rupestris L. Extract Attenuates Pulmonary Fibrosis by Inhibiting Fibroblast Activation and FMT via Targeting of TGF-β1.
Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes.
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis.
Impact of Escherichia coli and Lipopolysaccharide on the MAPK Signaling Pathway, MMPs, TIMPs, and the uPA System in Bovine Mammary Epithelial Cells.
Cytotoxicity and inhibitory potential of CUDC-101 in non-small cell lung cancer cells with rare EGFR L861Q mutation.
Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling.
Qingfei Formula Protects against Human Respiratory Syn cytial Virus-induced Lung Inflammatory Injury by Regulating the M APK Signaling Pathway.
Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.
miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK.
Transient Receptor Potential Ankyrin 1 (TRPA1) Mediated LPS-Induced Inflammation in Periodontal Ligament Stem Cells by Inhibiting the Phosphorylation of JNK.
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
Dual role of CD73 as a signaling molecule and adenosine-generating enzyme in colorectal cancer progression and immune evasion.
Ferroptosis-related gene MAPK3 is associated with the neurological outcome after cardiac arrest.
FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.
Naodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway.
Fusobacterium Nucleatum Aggravates Intestinal Barrier Impairment and Colitis Through IL-8 Induced Neutrophil Chemotaxis by Activating Epithelial Cells.
Cistanche deserticola polysaccharide alleviates constipation by regulating intestinal barrier function and intestinal microbiota and their metabolites.
Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway.
Inhibition of Sat1 alleviates myocardial ischemia-reperfusion injury through regulation of ferroptosis via MAPK/ERK pathway.
Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment.
γ-Synuclein promotes proliferation and inhibits apoptosis of oral squamous cell carcinoma via JAK2/STAT5b signaling pathway.
Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling.
Endogenous hydrogen sulfide accelerated trauma-induced heterotopic ossification through the Ca(2+)/ERK pathway-enhanced aberrant osteogenic activity.
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
The effects and mechanisms of AM1241 in alleviating cerebral ischemia-reperfusion injury.
Melatonin reverses EGFR-TKI therapeutic resistance by modulating crosstalk between circadian-related gene signature and immune infiltration patterns in patients with COVID-19 and lung adenocarcinoma.
Theabrownin from Pu-erh Tea Improves DSS-Induced Colitis via Restoring Gut Homeostasis and Inhibiting TLR2&4 Signaling Pathway.
Canthin-6-one analogs block Newcastle disease virus proliferation via suppressing the Akt and ERK pathways.
Tumoral EIF4EBP1 regulates the crosstalk between tumor-associated macrophages and tumor cells in MRTK.
Bioinspired Collagen Scaffold Loaded with bFGF-Overexpressing Human Mesenchymal Stromal Cells Accelerating Diabetic Skin Wound Healing via HIF-1 Signal Pathway Regulated Neovascularization.
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Spinster homolog 2/S1P signaling ameliorates macrophage inflammatory response to bacterial infections by balancing PGE(2) production.
Neohesperidin Attenuates DSS-Induced Ulcerative Colitis by Inhibiting Inflammation, Reducing Intestinal Barrier Damage, and Modulating Intestinal Flora Composition.
Omics-based pharmacological evaluation reveals Yuanhu Zhitong oral liquid ameliorates arthritis by regulating PKC/ERK/NF-κB signaling pathway.
CREB1 promotes cholangiocarcinoma metastasis through transcriptional regulation of the LAYN-mediated TLN1/β1 integrin axis: CREB1 promotes cholangiocarcinoma metastasis through regulating LAYN/TLN1/β1 integrin axis.
ACYP2 functions as an innovative nano-therapeutic target to impede the progression of hepatocellular carcinoma by inhibiting the activity of TERT and the KCNN4/ERK pathway.
Design, synthesis, and biological evaluation of naphthalene imidazo[1,2-b]pyridazine hybrid derivatives as VEGFR selective inhibitors.
Single-cell and spatial transcriptomics reveal apelin/APJ pathway's role in microvessel formation and tumour progression in hepatocellular carcinoma.
Structure characterization and immunological activity of capsular polysaccharide from live and heat-killed Lacticaseibacillus paracasei 6235.
EREG silencing inhibits tumorigenesis via inactivating ERK/p38 MAPK pathway in pancreatic ductal adenocarcinoma.
MAPK signaling pathway participates in the regulation of intestinal phosphorus and calcium absorption in broiler chickens via 1,25-dihydroxyvitamin D(3).
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Aldo-keto reductase family 1 member C3 mediates radioresistance of esophageal cancer cells through suppressing MAPK and AKT signaling.
Inhibition of neutrophil swarming by type I interferon promotes intracellular bacterial evasion.
The protective mechanism of Tao Hong Si Wu decoction against breast cancer through regulation of EGFR/ERK1/2 signaling.
Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4.
Exploring the Effect of Fidgetin-Like 1 on Colorectal Cancer Through Tissue Chip and In Vitro Experiments.
CD74(+) fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloids.
Lactobacillus paracasei subsp. paracasei NTU 101 prevents obesity by regulating AMPK pathways and gut microbiota in obese rat.
Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion.
Co-Mn Complex Oxide Nanoparticles as Potential Reactive Oxygen Species Scavenging Agents for Pulmonary Fibrosis Treatment.
Phytochemical determination and mechanistic investigation of Polygala tenuifolia root (Yuanzhi) extract for bronchitis: UPLC-MS/MS analysis, network pharmacology and in vitro/in vivo evaluation.
Exploring the anti-inflammatory and immune regulatory effects of Taohe Chengqi decoction in sepsis-induced lung injury.
Colon Cancer-Derived Exosomal LncRNA-XIST Promotes M2-like Macrophage Polarization by Regulating PDGFRA.
A novel role for WZ3146 in the inhibition of cell proliferation via ERK and AKT pathway in the rare EGFR G719X mutant cells.
CircCOCH plays a critical role in Hepatocellular carcinoma through modulating miR-450a and activating PI3K/mTOR pathway.
Luteolin detoxifies DEHP and prevents liver injury by degrading Uroc1 protein in mice.
Nuclear receptor 4A1 (NR4A1) upregulated by n-butylidenephthalide via the mitogen-activated protein kinase (MAPK) pathway ameliorates drug-induced gingival enlargement.
Enhancing DOX efficacy against NSCLC through UDCA-mediated modulation of the TGF-β/MAPK autophagy pathways.
Novel EGFR inhibitors against resistant L858R/T790M/C797S mutant for intervention of non-small cell lung cancer.
Dayuan Yin alleviates symptoms of HCoV-229E-induced pneumonia and modulates the Ras/Raf1/MEK/ERK pathway.
Low-Medium Polarity Ginsenosides from Wild Ginseng Improves Immunity by Activating the AhR/MAPK Pathway through Tryptophan Metabolism Driven by Gut Microbiota.
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain-induced cognitive impairment via microglial DUSP6 pathway in rats.
Novel analgesic peptide derived from Cinobufacini injection suppressing inflammation and pain via ERK1/2/COX-2 pathway.
One-Step Gas Foaming Strategy for Constructing Strontium Nanoparticle Decorated 3D Scaffolds: a New Platform for Repairing Critical Bone Defects.
7-hydroxycoumarin ameliorates ulcerative colitis in mice by inhibiting the MAPK pathway and alleviating gut microbiota dysbiosis.
Fentanyl induces analgesic effect through miR-381-3p/TRPM7 when combined with bupivacaine in subarachnoid injection.
iPSC-derived NK cells with site-specific integration of CAR19 and IL24 at the multi-copy rDNA locus enhanced antitumor activity and proliferation.
Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome.
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.
Paeonol interferes with lupus nephritis by regulating M1/M2 polarization of macrophages.
D-alanine suppressed osteoclastogenesis derived from bone marrow macrophages and downregulated ERK/p38 signalling pathways.
Systemic loss of CD36 aggravates NAFLD-related HCC through MEK1/2-ERK1/2 signaling pathway.
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis.
Patient tissue-derived FGFR4-variant and wild-type colorectal cancer organoid development and anticancer drug sensitivity testing.
BDTX-189, a novel tyrosine kinase inhibitor, inhibits cell activity via ERK and AKT pathways in the EGFR C797S triple mutant cells.
Oral Administration of Deer Bone Collagen Peptide Can Enhance the Skin Hydration Ability and Antioxidant Ability of Aging Mice Induced by D-Gal, and Regulate the Synthesis and Degradation of Collagen.
CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma.
Naringin attenuates Actinobacillus pleuropneumoniae-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway.
GPS2 ameliorates cigarette smoking-induced pulmonary vascular remodeling by modulating the ras-Raf-ERK axis.
Classical prescription Floris Sophorae Powder treat colorectal cancer by regulating KRAS/MEK-ERK signaling pathway.
Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota-Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice.
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Crocin Inhibits Orbital Fibroblasts Fibrosis in Thyroid-Associated Ophthalmopathy.
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Mucous cell histopathology and label-free quantitative proteomic analysis of skin mucus in fat greenling (Hexagrammos otakii) infected with Vibrio harveyi.
Therapeutic potential of SHCBP1 inhibitor AZD5582 in pancreatic cancer treatment.
Caffeic acid-grafted chitooligosaccharides downregulate MAPK and NF-kB in RAW264.7 cells.
Antibacterial, ROS scavenging and angiogenesis promotingϵ-Polylysine/gelatin based hydrogel containing CTLP to regulate macrophages for pressure ulcer healing.
CETSA-MS-based target profiling of anti-aging natural compound quercetin.
Protective Effects of Carbonated Chitosan Montmorillonite on Vomitoxin-Induced Intestinal Inflammation.
Soybean-derived antihypertensive hydrolysates attenuate Ang II-induced renal damage by modulating MAPK and NF-κB signaling pathways.
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.
N6-methyladenosine-modified CircPSMA7 enhances bladder cancer malignancy through the miR-128-3p/MAPK1 axis.
Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis.
Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice.
Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.
Downregulation of HIGD1B induces mitochondria-mediated apoptosis in gastric cancer cells by inactivating Akt and ERK pathways.
Gallic Acid Attenuates Sepsis-Induced Liver Injury through C/EBPβ-Dependent MAPK Signaling Pathway.
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest.
Deciphering the antidepressant effects of Rosa damascena essential oil mediated through the serotonergic synapse signaling pathway.
A specific super-enhancer actuated by berberine regulates EGFR-mediated RAS-RAF1-MEK1/2-ERK1/2 pathway to induce nasopharyngeal carcinoma autophagy.
Tris (2-chloroisopropyl) phosphate and Tris (nonylphenyl) phosphite Promote Human Renal Cell Apoptosis through the ERK/CEPBA/Long Non-Coding RNA Cytoskeleton Regulator Axis.
Intracellular magnetic hyperthermia reverses sorafenib resistance in hepatocellular carcinoma through its action on signaling pathways.
Chondroitin sulfate/silk fibroin hydrogel incorporating graphene oxide quantum dots with photothermal-effect promotes type H vessel-related wound healing.
d-mannose targets PD-1 to lysosomal degradation and enhances T cell-mediated anti-tumor immunity.
Structural elucidation and anti-psoriasis activity of a novel polysaccharide from Saussurea Costus.
Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.
SHED-exos promote saliva secretion by suppressing p-ERK1/2-mediated apoptosis in glandular cells.
LncRNA AC100826.1 regulated PLCB1 to promote progression in non-small cell lung cancer.
GRP78 Downregulation in Keratinocytes Promotes Skin Inflammation through the Recruitment and Activation of CCR6(+) IL-17A-Producing γδ T Cells.
THSG alleviates cerebral ischemia/reperfusion injury via the GluN2B-CaMKII-ERK1/2 pathway.
Integration analysis of cell division cycle-associated family genes revealed potential mechanisms of gliomagenesis and constructed an artificial intelligence-driven prognostic signature.
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
Narirutin mitigates dextrose sodium sulfate-induced colitis in mice by modulating intestinal flora.
Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats.
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas.
SETD8 inhibits apoptosis and ferroptosis of Ewing's sarcoma through YBX1/RAC3 axis.
Maternal high fat diet programs spatial learning and central leptin signaling in mouse offspring in a sex-specific manner.
Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.
Amplifying T cell-mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti-PD1.
Inulin alters gut microbiota to alleviate post-stroke depressive-like behavior associated with the IGF-1-mediated MAPK signaling pathway.
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca(2+) antagonism and maintaining mitochondrial function.
Polysaccharide from Artocarpus heterophyllus Lam. (Jackfruit) Pulp Ameliorates Dextran Sodium Sulfate-Induced Enteritis in Rats.
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Investigation of Tongxie-Yaofang formula in treating ulcerative colitis based on network pharmacology via regulating MAPK/AKT signaling pathway.
Bioinformatics and experimental studies jointly reveal that Sacubitril Valsartan improves myocardial oxidative stress and inflammation by regulating the MAPK signaling pathway to treat chemotherapy related cardiotoxicity.
Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway.
Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK/NF-κB pathways.
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice.
Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts.
Bufei Yishen formula protects the airway epithelial barrier and ameliorates COPD by enhancing autophagy through the Sirt1/AMPK/Foxo3 signaling pathway.
BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response.
An Inulin-Type Fructan CP-A from Codonopsis pilosula Alleviated 5-Fluorouracil-Induced Intestinal Mucositis via the ERK/MLCK/MLC2 Pathway and Regulation of Gut Microbiota.
JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway.
Puerarin Ameliorated PCOS through Preventing Mitochondrial Dysfunction Dependent on the Maintenance of Intracellular Calcium Homeostasis.
Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer.
Sasanquasaponin from Camellia oleifera Abel Exerts an Anti-Inflammatory Effect in RAW 264.7 Cells via Inhibition of the NF-κB/MAPK Signaling Pathways.
Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells.
CP41, a novel curcumin analogue, induces apoptosis in endometrial cancer cells by activating the H3F3A/ proteasome-MAPK signaling pathway and enhancing oxidative stress.
Therapeutic potential of Lacticaseibacillus rhamnosus grx10 and its derived postbiotic through gut microbiota and MAPK/MLCK/MLC pathway-mediated intestinal barrier repairment in ulcerative colitis.
Amphotericin B for injection triggers degranulation of human LAD2 mast cells by MRGPRX2 and pseudo-allergic reactions in mice via MRGPRB2 activation.
Peptidylprolyl isomerase D circular RNA sensitizes breast cancer to trastuzumab through remodeling HER2 N4-acetylcytidine modification.
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.
G protein-coupled receptor kinase 2 as a novel therapeutic target for gland fibrosis of Sjögren's syndrome.
Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model.
Folic acid mitigates the developmental and neurotoxic effects of bisphenol A in zebrafish by inhibiting the oxidative stress/JNK signaling pathway.
SPRY4 regulates ERK1/2 phosphorylation to affect oxidative stress and steroidogenesis in polycystic ovary syndrome.
CTGF regulated by ATF6 inhibits vascular endothelial inflammation and reduces hepatic ischemia-reperfusion injury.
Molecular mechanism through which Tripterygium hypoglaucum (Lévl.) Hutch alleviates psoriasis.
Proteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection.
Inhibition of JNK/STAT3/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin.
Baliosperoid A attenuates lipopolysaccharide-induced acute lung injury by targeting SHP2 to inhibit inflammation and oxidative stress.
Inhibiting TRIM8 alleviates adipocyte inflammation and insulin resistance by regulating the DUSP14/MAPKs pathway.
Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption.
Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.
Quercetin-primed BMSC-derived extracellular vesicles ameliorate chronic liver damage through miR-136-5p and GNAS/STAT3 signaling pathways.
RG108 attenuates acute kidney injury by inhibiting P38 MAPK/FOS and JNK/JUN pathways.
NLRP12 c.1382dup promotes the development of Crohn's disease through the ERK/NLRP3/ IL-1β pathway.
Integrated multi-omics analysis and machine learning developed diagnostic markers and prognostic model based on Efferocytosis-associated signatures for septic cardiomyopathy.
Extracellular vesicles miR-31-5p promotes pancreatic cancer chemoresistance via regulating LATS2-Hippo pathway and promoting SPARC secretion from pancreatic stellate cells.
TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.
mRNA-Lipid Nanoparticle-Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple-Negative Breast Cancer.
Targeted treatment of rat AKI induced by rhabdomyolysis using BMSC derived magnetic exosomes and its mechanism.
Mahuang Fuzi Xixin decoction: A potent analgesic for neuropathic pain targeting the NMDAR2B/CaMKIIα/ERK/CREB pathway.
Network Pharmacological Analysis Combined with Experimental Verification to Explore the Effect of Ginseng Polypeptide on the Improvement of Diabetes Symptoms in db/db Mice.
miR-450a-2-3p targets ERK(1/2) to ameliorate ISO-induced cardiac fibrosis in mice.
Development of new dehydrocostuslactone derivatives for treatment of atopic dermatitis via inhibition of the NF-κB signaling pathway.
Targeting AGTPBP1 inhibits pancreatic cancer progression via regulating microtubules and ERK signaling pathway.
RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition.
Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species.
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis.
A TGF-β signaling-related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response.
Discovery of a Pimaradiene that Decreases Viability of MDA-MB-468 Cells Through Inhibition of EGFR Signaling Pathway.
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
The prenatal use of agmatine prevents social behavior deficits in VPA-exposed mice by activating the ERK/CREB/BDNF signaling pathway.
H(2)S-Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation.
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation.
Oxidative stress-induced temporal activation of ERK1/2 phosphorylates coreceptor of Wnt/β-catenin for myofibroblast formation in human lens epithelial cells.
BIBF1120 Protects against Diabetic Retinopathy through Neovascularization-Related Molecules and the MAPK Signaling Pathway.
Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways.
Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and Promotes Apoptosis and Autophagy of Gastric Cancer Cells.
Suppression of migration and invasion by taraxerol in the triple-negative breast cancer cell line MDA-MB-231 via the ERK/Slug axis.
Establishment of Risk Model and Analysis of Immunoinfiltration Based on Mitophagy-Related Associated Genes in Atrial Fibrillation.
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.
Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt's lymphoma cells by inhibiting AKT and ERK.
Exploration of the mechanism of aloin ameliorates of combined allergic rhinitis and asthma syndrome based on network pharmacology and experimental validation.
Supramolecular nanofibers co-loaded with dabrafenib and doxorubicin for targeted and synergistic therapy of differentiated thyroid carcinoma.
Copine 7 promotes colorectal cancer proliferation through PKM2 interaction and MAPK signaling pathway.
The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin.
Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance.
A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement.
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization.
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Yueju volatile oil plays an integral role in the antidepressant effect by up-regulating ERK/AKT-mediated GLT-1 expression to clear glutamate.
Oridonin inhibits the occurrence and development of colorectal cancer by reversing the Warburg effect via reducing PKM2 dimer formation and preventing its entry into the nucleus.
Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.
Long-Term Exposure to Microcystin-LR Induces Gastric Toxicity by Activating the Mitogen-Activated Protein Kinase Signaling Pathway.
Inhibition of FNDC1 suppresses gastric cancer progression by interfering with Gβγ-VEGFR2 complex formation.
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Formin-related protein 1 facilitates proliferation and aggressive phenotype of clear cell renal cell carcinoma through MAPK/MMP2 pathway.
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Identification of a receptor tyrosine kinase inhibitor CP-724714 inhibits SADS-CoV related swine diarrhea coronaviruses infection in vitro.
HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway.
Lens epithelial cell-derived exosome inhibits angiogenesis in ocular pathological neovascularization through its delivery of miR-146a-5p.
Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus.
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Transcriptome Analysis Revealed Potential Genes of Skeletal Muscle Thermogenesis in Mashen Pigs and Large White Pigs under Cold Stress.
FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke.
Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation.
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Multi-omics reveals aging-related pathway in natural aging mouse liver.
Ketamine counteracts sevoflurane-induced depressive-like behavior and synaptic plasticity impairments through the adenosine A2A receptor/ERK pathway in rats.
Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation.
Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling.
The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection.
Study on the Alleviating Effect and Potential Mechanism of Ethanolic Extract of Limonium aureum (L.) Hill. on Lipopolysaccharide-Induced Inflammatory Responses in Macrophages.
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma.
Methionine sulfoxide suppresses adipogenic differentiation by regulating the mitogen-activated protein kinase signaling pathway.
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.
The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis.
Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation.
Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway.
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway.
Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation.
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways.
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.
Chitosan targets PI3K/Akt/FoxO3a axis to up-regulate FAM172A and suppress MAPK/ERK pathway to exert anti-tumor effect in osteosarcoma.
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
Exercise-induced endothelial Mecp2 lactylation suppresses atherosclerosis via the Ereg/MAPK signalling pathway.
Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex.
The Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple.
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway.
Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production.
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Endothelial progenitor cell-derived exosomes inhibit pulmonary artery smooth muscle cell in vitro proliferation and resistance to apoptosis by modulating the Mitofusin-2 and Ras-Raf-ERK1/2 signaling pathway.
Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia.
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice.
A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer.
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Elevated retinal fibrosis in experimental myopia is involved in the activation of the PI3K/AKT/ERK signaling pathway.
Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.
Resveratrol May Reduce the Degree of Periodontitis by Regulating ERK Pathway in Gingival-Derived MSCs.
TRPC6 promotes daunorubicin-induced mitochondrial fission and cell death in rat cardiomyocytes with the involvement of ERK1/2-DRP1 activation.
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.
HIV Tat-Conjugated Histone H3 Peptides Induce Tumor Cell Death Via Cellular Stress Responses.
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation.
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.
Deficit of PKHD1L1 in the dentate gyrus increases seizure susceptibility in mice.
Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis.
LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer.
CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.
Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.
Elevated PGT promotes proliferation and inhibits cell apoptosis in preeclampsia by Erk signaling pathway.
Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma.
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity.
Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia.
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Gelatin methacryloyl (GelMA) loaded with concentrated hypoxic pretreated adipose-derived mesenchymal stem cells(ADSCs) conditioned medium promotes wound healing and vascular regeneration in aged skin.
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Wen-Shen-Tong-Luo-Zhi-Tong Decoction regulates bone-fat balance in osteoporosis by adipocyte-derived exosomes.
Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.
Mechanisms of dihydromyricetin against hepatocellular carcinoma elucidated by network pharmacology combined with experimental validation.
Sema3A inactivates the ERK/JNK signalling pathways to alleviate inflammation and oxidative stress in lipopolysaccharide-stimulated rat endothelial cells and lung tissues.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Herbal compound cepharanthine attenuates inflammatory arthritis by blocking macrophage M1 polarization.
Liensinine improves AngII-induced vascular remodeling via MAPK/TGF-β1/Smad2/3 signaling.
The ethanol extract of Scutellaria baicalensis Georgi attenuates complete Freund's adjuvant (CFA)-induced inflammatory pain by suppression of P2X3 receptor.
Modification of osimertinib to discover new potent EGFR(C797S)-TK inhibitors.
Discovery of highly potent and selective KRAS(G12C) degraders by VHL-recruiting PROTACs for the treatment of tumors with KRAS(G12C)-Mutation.
Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE(-/-) Mice.
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation.
GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.
Ultrasound-targeted microbubble destruction promotes PDGF-primed bone mesenchymal stem cell transplantation for myocardial protection in acute Myocardial Infarction in rats.
Banxia Xiexin decoction ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis via inhibiting serine-threonine protein kinase (Akt)/mitogen-activated protein kinase (MAPK) signaling pathway.
Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo.
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
The Inhibitory Effect of RADKPS on Pyroptosis of Nucleus Pulposus-Derived Mesenchymal Stem Cells.
ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy.
PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer.
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling.
Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell.
Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling.
Exosomes incorporated with black phosphorus quantum dots attenuate retinal angiogenesis via disrupting glucose metabolism.
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
Promoted Skin Wound Healing by Tail-Amputated Eisenia foetida Proteins via the Ras/Raf/MEK/ERK Signaling Pathway.
SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway.
Subchronic Microcystin-LR Aggravates Colorectal Inflammatory Response and Barrier Disruption via Raf/ERK Signaling Pathway in Obese Mice.
CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study.
7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells.
Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction.
Sufentanil Alleviates Sepsis-Induced Myocardial Injury and Stress Response in Rats through the ERK/GSK-3β Signaling Axis.
Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain.
Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors.
Systematic Pharmacology-Based Strategy to Explore the Mechanism of Bufei Huoxue Capsule in the Treatment of Chronic Obstructive Pulmonary Disease.
Smart thermosensitive poloxamer hydrogels loaded with Nr-CWs for the treatment of diabetic wounds.
METTL3 Facilitates Tumor Progression by COL12A1/MAPK Signaling Pathway in Esophageal Squamous Cell Carcinoma.
Bu-Gu-Sheng-Sui decoction promotes osteogenesis via activating the ERK/Smad signaling pathways.
Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.
Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro.
Dysfunction of CCR1(+) decidual macrophages is a potential risk factor in the occurrence of unexplained recurrent pregnancy loss.
High-Metastatic Melanoma Cells Promote the Metastatic Capability of Low-Metastatic Melanoma Cells via Exosomal Transfer of miR-411-5p.
The Specifically Androgen-Regulated Gene (SARG) Promotes Papillary Thyroid Carcinoma (PTC) Lymphatic Metastasis Through Vascular Endothelial Growth Factor C (VEGF-C) and VEGF Receptor 3 (VEGFR-3) Axis.
Poloxamer 407 and Hyaluronic Acid Thermosensitive Hydrogel-Encapsulated Ginsenoside Rg3 to Promote Skin Wound Healing.
HIV-1 Tat Protein-Mediated Inflammatory Response Inhibits the Erythroid Hematopoietic Support Function of Bone Marrow Mesenchymal Stem Cells.
Interleukin 32 participates in cardiomyocyte-induced oxidative stress, inflammation and apoptosis during hypoxia/reoxygenation via the NOD2/NOX2/MAPK signaling pathway.
Traditional herbal formula Jiao-tai-wan improves chronic restrain stress-induced depression-like behaviors in mice.
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia.
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Combination of RSK inhibitor LJH-685 and FLT3 inhibitor FF-10101 promoted apoptosis and proliferation inhibition of AML cell lines.
Cpd-0225 attenuates renal fibrosis via inhibiting ALK5.
Identification of four STAT3 isoforms and functional investigation of IL-6/JAK2/STAT3 pathway in blunt snout bream (Megalobrama amblycephala).
Triclocarban evoked neutrophil extracellular trap formation in common carp (Cyprinus carpio L.) by modulating SIRT3-mediated ROS crosstalk with ERK1/2/p38 signaling.
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Exosomal DNAJB11 promotes the development of pancreatic cancer by modulating the EGFR/MAPK pathway.
ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8.
Autophagy triggered by the ROS/ERK signaling pathway protects mouse embryonic palatal cells from apoptosis induced by nicotine.
Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa.
Non-Muscle MLCK Contributes to Endothelial Cell Hyper-Proliferation through the ERK Pathway as a Mechanism for Vascular Remodeling in Pulmonary Hypertension.
Orally Administered Ginkgolide C Attenuates DSS-Induced Colitis by Maintaining Gut Barrier Integrity, Inhibiting Inflammatory Responses, and Regulating Intestinal Flora.
Effects of Camk2b Overexpression and Underexpression on the Proteome of Rat Hippocampal Neurons.
Effects of thymoquinone against angiotensin II‑induced cardiac damage in apolipoprotein E‑deficient mice.
Optimization of the saffron compound essence formula and its effect on preventing skin photoaging.
Immunomodulatory activity of aqueous extract from Crassostrea sikamea in the splenocytes of Sprague-Dawley rats.
Downregulation of lncRNA SNHG16 inhibits vascular smooth muscle cell proliferation and migration in cerebral atherosclerosis by targeting the miR-30c-5p/SDC2 axis.
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
Blockade of mIL-6R alleviated lipopolysaccharide-induced systemic inflammatory response syndrome by suppressing NF-κB-mediated Ccl2 expression and inflammasome activation.
A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells.
MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway.
Near-Infrared Light-Responsive Nanoinhibitors for Tumor Suppression through Targeting and Regulating Anion Channels.
Effect of Qingyangshen glycosides on social defeat mice model.
Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway.
Investigation of cell cytotoxic activity and molecular mechanism of 5β,19-epoxycucurbita-6,23(E)-diene-3β,19(R),25-triol isolated from Momordica charantia on hepatoma cells.
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites.
The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
Downregulation of IL-8 and IL-10 by the Activation of Ca(2+)-Activated K(+) Channel K(Ca)3.1 in THP-1-Derived M(2) Macrophages.
Rhodococcus equi-Derived Extracellular Vesicles Promoting Inflammatory Response in Macrophage through TLR2-NF-κB/MAPK Pathways.
Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells.
piR-121380 Is Involved in Cryo-Capacitation and Regulates Post-Thawed Boar Sperm Quality Through Phosphorylation of ERK2 via Targeting PTPN7.
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology.
Comparative Efficacy of Haizao Yuhu Decoction Composed of Different Varieties of Glycyrrhiza in Goiter Rats.
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer.
Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway.
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine.
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.
1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways.
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.
Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling.
Effects of Saccharides from Arctium lappa L. Root on FeCl(3)-Induced Arterial Thrombosis via the ERK/NF-κB Signaling Pathway.
MiR-1307-5p targeting TRAF3 upregulates the MAPK/NF-κB pathway and promotes lung adenocarcinoma proliferation.
Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression.
Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.
Resveratrol-loaded biopolymer core-shell nanoparticles: bioavailability and anti-inflammatory effects.
Inhibiting PKCβ2 protects HK-2 cells against meglumine diatrizoate and AGEs-induced apoptosis and autophagy.
Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts.
Hfm1 participates in Golgi-associated spindle assembly and division in mouse oocyte meiosis.
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice.
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
MiR-96-5p promotes breast cancer migration by activating MEK/ERK signaling.
PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation.
Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling.
Soluble epoxide hydrolase inhibition alleviated cognitive impairments via NRG1/ErbB4 signaling after chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis in mice.
Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.
Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.
Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.
HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth.
SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway.
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca²⁺-dependent ERK signaling pathway.
Polychlorinated biphenyl quinone induces endothelial barrier dysregulation by setting the cross talk between VE-cadherin, focal adhesion, and MAPK signaling.
Tenascin-C induces resistance to apoptosis in pancreatic cancer cell through activation of ERK/NF-κB pathway.
Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions.
13-acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression.
MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway.
Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway.
Gu A, Wang B, Zhang Y, Sun C, Wei Y, Yan J, Yang Y, Wang Y, Liu R, Zhang R, Liu J, Gu C, Wang Y
Research (Washington, D.C.) 2026;9:1069
Research (Washington, D.C.) 2026;9:1069
Lymph Node Metastasis-Associated Spatiotemporal Mapping of the TFF3-Linked Niche in Breast Cancer: Integrating Radiogenomic Signatures with Immune-Ecosystem Remodeling.
Cai D, Zhu C, Huang H, Cao Y, Cai G, Chen Z, Feng J, Zhang W, Mao W, Lai J
Research (Washington, D.C.) 2026;9:1016
Research (Washington, D.C.) 2026;9:1016
Triptonide-mediated PTGS2 Inhibition Induces Autophagic Cell Death to Suppress the Progression of Triple-negative Breast Cancer and Epithelial Ovarian Cancer.
Gong K, Song K, Wang H, Li L, Sun X, Sun L, Hao W, Chen ZS, Huang Y
International journal of biological sciences 2026;22(5):2215-2232
International journal of biological sciences 2026;22(5):2215-2232
DJ-1 alleviates high glucose-induced podocyte injury via activating ERK1/2 signaling.
Tian X, Li J, Han T, Zhang L, Lu P, Liu Y
PloS one 2026;21(4):e0346714
PloS one 2026;21(4):e0346714
Research on the Inhibition of Cancer Cell Metastasis by Graphene Oxide Suppresses the Translation of the Snail mRNA.
Wei X, Luo C, Ming X, Jia X, Long P, Feng L, Zhu M, Hu X, Li M, Li H
International journal of nanomedicine 2026;21:590745
International journal of nanomedicine 2026;21:590745
Wuji Wan ameliorates ulcerative colitis by restoring impaired membrane transport.
Zhang J, Zhang Y, Guo Y, Sun Y, Li Y, Li Q, Chen Y, Wang Y, Yang Q, Zhang M, Weng X, Deng Z
Frontiers in pharmacology 2026;17:1718919
Frontiers in pharmacology 2026;17:1718919
Research on the correlation and potential mechanism of PKCδ expression with efficacy and prognosis in diffuse large B-cell lymphoma.
Zhao X, Li S, Zhu L, Wu M, Hu X, Liang X, Wang S, Maihemaiti A, Adili A, Wen S
Frontiers in oncology 2026;16:1690426
Frontiers in oncology 2026;16:1690426
PLOD2 Promotes Cutaneous Squamous Cell Carcinoma Progression in Association With STAT3-Related ERK and AKT Pathways.
Xian N, Wang Z, Wang B, Wang X, Zheng Y
Molecular carcinogenesis 2026 May;65(5):615-629
Molecular carcinogenesis 2026 May;65(5):615-629
Farnesol Targets the GSTP1/MAPK Axis to Inhibit Trauma-Induced Tendon Heterotopic Ossification.
Deng X, Li T, Li G, Zhu T, Kong Y, Fu B, Li JJ, Chen C, Lei W, Jiang G, Zhang K
Phytotherapy research : PTR 2026 May;40(5):2692-2709
Phytotherapy research : PTR 2026 May;40(5):2692-2709
Taohong Siwu decoction and its components regulate the M1/M2 polarization of macrophages to alleviate inflammatory injury in sepsis via the RAGE.
Han X, Pang M, Hu C, Li Y, Xu T, Xu H, Ye H, Xie L, Shen A, Liu B, Zhang G, Zhou Y
Journal of ethnopharmacology 2026 May 10;362:121366
Journal of ethnopharmacology 2026 May 10;362:121366
Isoliquiritigenin restores bone homeostasis in osteoporotic rats by enhancing BMSCs osteogenesis via ERK1/2-mTOR-HIF-1α-glycolytic axis and suppressing inflammation.
Chang H, Li Y, Wang Z, Fang Z, Chen H, Xu C, Jiao X, Gan Y
International immunopharmacology 2026 May 1;176:116440
International immunopharmacology 2026 May 1;176:116440
Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense.
Zhang M, Wu J, Xu J, Hu X, Shi H, Huang W, Song L, Zhu J, Tan H, Yu R
International journal of biological macromolecules 2026 Mar;352:151196
International journal of biological macromolecules 2026 Mar;352:151196
Mechanism of biomimetic virus-like nanoparticles in triggering immune response elucidated by proteomics.
Wang J, Montaser A, Sivonen M, Leinonen H, Nygård L, Kinnunen T, Pitkänen S, Levonen-Harju AL, Batnasan E, Latonen L, Hepojoki J, Ma L, Lehto VP, Xu W
Colloids and surfaces. B, Biointerfaces 2026 Mar;259:115338
Colloids and surfaces. B, Biointerfaces 2026 Mar;259:115338
Reversibly unlocking the blood-brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide.
Wu J, Cui G, Lin Z, Lin W, Zhang Y, Zhou T, He P, Zhang Y, Yao G
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1676-1695
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1676-1695
Aloe-emodin inhibits p38 MAPK pathway in Alzheimer's disease treatment: a network pharmacology and experimental verification.
Ouyang Z, Liu F, Lu Q, Wang Y, Shao N, Liu H, Cai B
Journal of molecular histology 2026 Mar 7;57(2)
Journal of molecular histology 2026 Mar 7;57(2)
Deficiency of interleukin-40 prevents intestinal damage in experimental necrotizing enterocolitis by inhibiting NETosis.
Zhang Y, Ye C, Zhong X, Ding X, Yang Y, Ma Y, Guo C
Cell communication and signaling : CCS 2026 Mar 7;24(1)
Cell communication and signaling : CCS 2026 Mar 7;24(1)
Red Blood Cell-Derived Exosomes Deliver Complement C5 to Exacerbate Neuroinflammation and Neuronal Injury after Intracerebral Hemorrhage.
Chen Q, Min J, Lu X, Gao Z, Xiong Y
Inflammation 2026 Mar 5;49(1)
Inflammation 2026 Mar 5;49(1)
PRMT1 facilitates the tumorigenesis of chronic lymphocytic leukemia by regulating methylation of MAST1.
Tian Z, Gao P, Zhang Y, Ma J, Hu X, Wang H, Lu L, Zhang Y, Wang X
Leukemia 2026 Mar 30;
Leukemia 2026 Mar 30;
Multi-omics and network pharmacology reveal the mechanisms of Scutellaria barbata D.Don and Scleromitrion diffusum (Willd.) R.J.Wang against pancreatic cancer.
Zhao Z, Yang Y, Zhang L, He X, Ding K, Chen Y, Huo Y, Li P, Li R, Ali T, Zhao D, Choe H, Ma J, Shang D, Zhang L
Scientific reports 2026 Mar 27;16(1)
Scientific reports 2026 Mar 27;16(1)
A tumor-resident bacterium promotes cervical cancer progression through lysoPC-mediated c-Jun/c-Fos activation.
Li C, Zhao H, Wang J, Liu C, He S, Zhou J, Li L, Liu Y, Wang Q, Shen X, Wu J, Chen G, Wang Y, Yang L, Du B
Cell reports 2026 Mar 24;45(3):117079
Cell reports 2026 Mar 24;45(3):117079
DSCAML1+ extracellular vesicles revealed by single-vesicle proteomics as a novel biomarker and therapeutic target in myocardial infarction.
Liu N, Wei G, Wang H, Zhang Y, Sun X, Lai F, Zheng Y, Hu K, Xu T, Su G, Huang R, Tong L
Journal of nanobiotechnology 2026 Mar 23;24(1)
Journal of nanobiotechnology 2026 Mar 23;24(1)
The enhanced osteogenic differentiation of human periodontal ligament stem cells and M2 polarization of macrophages may be mediated by EphB4/ephrinB2 signaling pathway: a study of their direct co-culture.
Yang X, Luan Y, Qiu J, Ren H, Yin Q, Liu H, Song H, Song A
Stem cell research & therapy 2026 Mar 2;17(1)
Stem cell research & therapy 2026 Mar 2;17(1)
Exposure to 2-chlorohydroquinone induces systemic vascular disorders and increases the risk of cerebral hemorrhage in zebrafish larvae.
Li J, Cheng H, Li Y, Zhu S, Liu W, Wang B, Shi X
Journal of hazardous materials 2026 Mar 15;506:141564
Journal of hazardous materials 2026 Mar 15;506:141564
PKA and PKC signaling pathways mediate vitamin D₃-regulated intestinal phosphorus absorption in broiler chickens.
Liu M, Xi L, Zhou Y, Chen M, Qu H, Ma B, Zhang L, Shi C, Chen G, Ren Z, Cao J, Han J
Poultry science 2026 Mar 12;105(6):106762
Poultry science 2026 Mar 12;105(6):106762
UBQLN1 Inhibition reduces MASH progression through downregulating SIKE/p38 MAPK pathway in hepatocyte.
Chen Y, Yang F, Zheng G, Wang Y, Liu L, Yan Y
Journal of nanobiotechnology 2026 Mar 11;24(1)
Journal of nanobiotechnology 2026 Mar 11;24(1)
Aspartame exacerbates cerebral ischemia-reperfusion injury via mitochondrial dysfunction and ERK/CREB1 pathway suppression.
Bai Y, Feng J, Wu XY, Yao ZS, Liu YT, Li YH, Lu GD, Xue K
Ecotoxicology and environmental safety 2026 Mar 1;312:119938
Ecotoxicology and environmental safety 2026 Mar 1;312:119938
Phycocyanin-functionalized selenium nanoparticles attenuate osteoarthritis through ferroptosis suppression and modulation of the MAPK pathway.
Hu J, Luo P, Zhang W, Chen T, Yang X, Chen Z, Huang S, Zhang X, Kuang Z, Zhang B
Materials today. Bio 2026 Jun;38:103113
Materials today. Bio 2026 Jun;38:103113
Hepatic cavernous hemangioma decellularized extracellular matrix/GelMA composite hydrogel promotes angiogenesis via the ITGA9-FAK-ERK1/2 axis.
Dai Z, Li X, Jin M, Liu W, Li X, Zhang C, Li F, Lin J, Zhou Z, Sun X, Wang T, Yang H, Zhang J
Materials today. Bio 2026 Jun;38:102976
Materials today. Bio 2026 Jun;38:102976
A natural product-hybridization approach toward anticancer drug discovery: synthesis and antitumor evaluation of CTBC6, designed from sulforaphane and magnolol.
Tao C, Chen M, Liu B, Chen H, Ji F, Huang J, Chen J, Guo Y, Liu X, Yuan H, Feng Y, Li Z, Cheng Y, Luo D, Wu D, Lin X, Xie J, Peng J, Chen Z
Bioorganic chemistry 2026 Jun 5;173:109697
Bioorganic chemistry 2026 Jun 5;173:109697
ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway.
Zhang H, Liu X, Ji X, Zhang G, Wang B, Xiong F, Sun D, Wang C
International immunopharmacology 2026 Jun 1;178:116558
International immunopharmacology 2026 Jun 1;178:116558
Neferine ameliorates psoriasis through inducing oxidative stress-mediated keratinocyte apoptosis and suppressing inflammatory response via the Keap1-Nrf2 pathway.
Cheng B, Zhang Z, Bai R, Du W, Le H, He K, Yin T, Wang Z, Liu X, Liu J, Zheng Y
Free radical biology & medicine 2026 Jul;250:517-534
Free radical biology & medicine 2026 Jul;250:517-534
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
Li G, Xu F, Luo S, Jin Y, Yuan L, Yang X, Xuan T, Liu D
International immunopharmacology 2026 Jul 1;180:116743
International immunopharmacology 2026 Jul 1;180:116743
HOMER3 drives oral squamous cell carcinoma progression through TRPV6 calcium influx and TUBB3 microtubule stabilization.
Xu C, Zhang J, Zhang H, Chen L, Zhao J, Yang G, Xiao R, Zhu J, Fan C, Yao Y, Sun S
Oncogene 2026 Jan;45(2):278-294
Oncogene 2026 Jan;45(2):278-294
Exploring the Potential Targets and Molecular Mechanisms of Selenomethionine to Attenuate Acute Kidney Injury Based on Network Pharmacology, Molecular Simulation Technology and Animal Experiments.
Pei J, Pan X, Zhan X, Wu M, Wang D, Yang Y, Lu F, Li Z, Tang H, An N, Peng J
Phytotherapy research : PTR 2026 Jan;40(1):100-115
Phytotherapy research : PTR 2026 Jan;40(1):100-115
Targeting aldose reductase in pulmonary fibrosis: Blocking de novo fatty acid synthesis halts pro-fibrotic M2 polarization.
Li J, Zhang Q, Zhao P, Mei X, Shi Y, Shao W, Yu X
International journal of biological macromolecules 2026 Jan;337(Pt 2):149590
International journal of biological macromolecules 2026 Jan;337(Pt 2):149590
Immunological activity of peach pectins: Insights from cells to animals.
Liu M, Liu X, Blecker C, Bi J
International journal of biological macromolecules 2026 Jan;337(Pt 2):149192
International journal of biological macromolecules 2026 Jan;337(Pt 2):149192
Effects of repetitive transcranial magnetic stimulation on apoptosis and MAPK/PI3K-AKT signaling pathways in rats with spinal cord injury.
Xu Q, Su J, Lei Q, Liu J, Wang J, Yang M, Song J, Chen H, Lu J
Brain research bulletin 2026 Jan;234:111687
Brain research bulletin 2026 Jan;234:111687
Pyraclostrobin induces brain oxidative stress, apoptosis and inflammation through mitochondrial phosphorylation-induced ROS activation of the p38 MAPK pathway.
Li Y, Chen J, Chen Y, Dong Q, Jin X, Zhao P, Dong Z
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106787
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106787
Hydrogen sulfide promotes proliferation and regeneration of human cerebral microvascular endothelial cells via the sonic hedgehog signaling pathway.
Chen HY, Huang JM, Zheng P, Yang GX, Qin BB, Zang MX, Wang J, Li XB
Open life sciences 2026 Jan;21(1):20251242
Open life sciences 2026 Jan;21(1):20251242
Echinacoside Improves Pulmonary Vascular Remodeling by Regulating the L- and T-Type Ca(2+) Channels in the Prevention and Treatment of Pulmonary Hypertension.
Zhao Y, Wang J, Qiao Y, Gai X, Hu J, Wang H, Xia Q, Hu Q, Li Z, Li C, Bi H
Pulmonary circulation 2026 Jan;16(1):e70235
Pulmonary circulation 2026 Jan;16(1):e70235
Lobetyolin alleviates microglial inflammation by activating CK2α/Opa1-mediated mitochondrial fusion in ischemic stroke.
Qin N, Liu R, Deng R, Jia W, Yang Y, Sun J, Gao S, Zhu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157651
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157651
Moutan cortex ameliorates perimenopausal syndrome by regulating the KISS1R-ERK1/2-GnRH signaling pathway: Evidence from serum pharmacochemistry and network pharmacology.
Huang M, Wang J, Ye Y, Chen W, Ai X, Chen X, Wang Y, Wang Y, Xu W
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120732
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120732
Dexmedetomidine alleviates sepsis-associated acute kidney injury by inhibiting renal tubular ferroptosis via JNK/MAPK-LCN2 pathway.
Liu B, Ao S, Luo L, Qiao L, Kuang T, Xiao H, Zhou J, Yin S, Liang H, Li F, Dai W, Zhu J
European journal of medical research 2026 Jan 26;31(1):315
European journal of medical research 2026 Jan 26;31(1):315
HUVEC-derived exosomes alleviate lipopolysaccharide-induced acute lung injury inflammation by restoring the balance of mitochondrial fusion and division.
Lai W, Ahan S, Ying Z, Jiang W
Cellular and molecular life sciences : CMLS 2026 Jan 22;83(1):92
Cellular and molecular life sciences : CMLS 2026 Jan 22;83(1):92
Vasicine Attenuates Allergic Asthma by Suppressing Mast Cell Degranulation and Th2 Inflammation via Modulation of the FcεRI/Lyn + Syk/MAPK Pathway.
Qu L, Du W, Ren Z, Chen M, Wu X, Cao X, Rao G, Tong X, Huang F, Sun Y
Pharmaceuticals (Basel, Switzerland) 2026 Jan 22;19(1)
Pharmaceuticals (Basel, Switzerland) 2026 Jan 22;19(1)
Zhigancao decoction alleviates Parkinson's disease via inhibiting TNF/NF-κB and Ras/ERK-mediated neuroinflammation and apoptosis.
Zhang J, Yu X, Fang Y, Li W, Cui Q, Liu X, Jiang Y, Zhang Y, Xu C, Sun X, Lu Y
iScience 2026 Jan 16;29(1):114489
iScience 2026 Jan 16;29(1):114489
The mechanism of indigo naturalis and its active ingredients against ulcerative colitis.
Ma KY, Hou BL, Fan AQ, Huang AL, Li BR, Liang YN, Wang Z
Scientific reports 2026 Jan 14;16(1):5220
Scientific reports 2026 Jan 14;16(1):5220
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in hepatocellular carcinoma cells.
Wang Y, Zhang Z, Cao L, Huang S, Huang X, Zhang Z, Zhang Y, Li X
Journal of ethnopharmacology 2026 Jan 10;354:120492
Journal of ethnopharmacology 2026 Jan 10;354:120492
Promoter Methylation of WIF1 is Involved in IL-17-Induced Chondrocyte Inflammatory Injury and Matrix Degradation via Promoting Wnt5a/MAPK-JNK Signaling.
Chen X, Chen X, Xie J, Guo D
Molecular biotechnology 2026 Feb;68(2):496-506
Molecular biotechnology 2026 Feb;68(2):496-506
STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma.
Hu H, Zhang H, Han S, Chen J, Xie Y
International journal of molecular medicine 2026 Feb;57(2)
International journal of molecular medicine 2026 Feb;57(2)
Cycloastragenol Regulates Mitochondrial Homeostasis-Mediated Renal Tubular Injury to Ameliorate Diabetic Kidney Disease by Directly Targeting ERK to Modulate TFEB.
Gao G, Liu Z, Wang H, Wang P, Liu S, Liu R, Wu Y, Wang Z, Xu J, Zhang Z, Zhang X, Xie Z
Phytotherapy research : PTR 2026 Feb;40(2):455-472
Phytotherapy research : PTR 2026 Feb;40(2):455-472
Modulation of endothelial-to-mesenchymal transition via NRP-1 targeting with melittin attenuates pulmonary fibrosis.
Hu M, Wan Y, Chen J, Zhang C, Li S, Shan B, Wu L, Yu X
Materials today. Bio 2026 Feb;36:102659
Materials today. Bio 2026 Feb;36:102659
Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents.
Liu XA, Aguirre CA, Yang Q, Ren J, Wang L, Ju F, Guo H, Wang J, Liu L, Li Z, He J, Xu Z, Shi C, Cintron-Colon R, Michel T, Wood M, Margetts AV, Pollock TA, Vilca SJ, Tuesta LM, Di Angelantonio S, Basilico B, De Stefano ME, Xia J, Wei P, Li S, Yang X, Wang L, Delorme-Walker VD, Marcondes MCG, Parsons L, Conti B, Chen Z
Molecular psychiatry 2026 Feb;31(2):622-634
Molecular psychiatry 2026 Feb;31(2):622-634
Biomimetic Multilayered Gas-Foaming Scaffold with Sustained bFGF Delivery for Annulus Fibrosus Regeneration.
Chen Y, Li Y, Wei Z, Du L, Qian M, Wang J, Mo X, Deng Z, Ye X, Yu J
Advanced healthcare materials 2026 Feb;15(7):e02833
Advanced healthcare materials 2026 Feb;15(7):e02833
Ursodeoxycholic acid alleviates α-Casein-induced cow's milk protein allergy via the TGR5/NF-κB signaling pathway.
Yu Z, Wang Z, Yue L, Wang Y, Sun B, Wang R, Zhu X, Li L, Zhang W, Li X
Scientific reports 2026 Feb 9;16(1)
Scientific reports 2026 Feb 9;16(1)
Exploration of borneol essential oil function in the treatment of Alzheimer's disease based on network pharmacology and experimental validation.
You C, Wu S, Zhang Y, Li Q, Cui Y, Wu Y
BMC complementary medicine and therapies 2026 Feb 4;26(1)
BMC complementary medicine and therapies 2026 Feb 4;26(1)
Anti-inflammatory effects and mechanisms of Podophyllum hexandrum rhizomes and fruits in a chronic pelvic inflammatory disease rat model.
Zhang B, Yang AT, Wang LN, Yu Q, Tan CC, Chao WH, Geng HY, Pei TX, Zhang L, Cao SJ, Qiu F, Kang N
Journal of ethnopharmacology 2026 Feb 28;357:120954
Journal of ethnopharmacology 2026 Feb 28;357:120954
Role of CTGF-LRP1 in impaired healing of cesarean section incisions.
He C, Ge S, Xia W, Wang Y, Yan L, Sun J, Yan L, Zhu Q, Zhao X, Zhang J
Nature communications 2026 Feb 28;17(1)
Nature communications 2026 Feb 28;17(1)
Self-Assembled Rg3/Naringenin Nanoparticles for Targeted Brain Delivery: A Promising Therapeutic Approach for Early Alzheimer's Disease.
Lou X, Ni Z, Cui S, He Z, Zong Y, Chen W, Geng J, Zhou J, Li Z, Zhao Y, Teng H
Pharmaceuticals (Basel, Switzerland) 2026 Feb 26;19(3)
Pharmaceuticals (Basel, Switzerland) 2026 Feb 26;19(3)
AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.
Li Q, Bao Q, Wei C, Xie Y, Zhao S, Yan H, Wu F, Li W, Liu X, Gao H
Investigative ophthalmology & visual science 2026 Feb 2;67(2):22
Investigative ophthalmology & visual science 2026 Feb 2;67(2):22
The P7 peptide antagonizes bFGF-induced malignant behaviors of ovarian cancer by inhibiting MEK/ERK signaling pathway.
Yang Z, Wei W, Nie D, Zhang M, Chen Q
Future science OA 2026 Dec;12(1):2615619
Future science OA 2026 Dec;12(1):2615619
A novel AGTPBP1-ERK/MYLK network mediates pancreatic cancer progression.
Yang ZY, Zhang Q, Yang JR, Zhang XD, Liu CL, Huang JY, Xiao R, Ren JJ
Tissue & cell 2026 Aug;101:103512
Tissue & cell 2026 Aug;101:103512
U0126 induces osteoclast differentiation via the p38-NFATc-1 signaling pathway.
Wang J, Liu J, Jia X, Chen G, Chen S, Huang X
Tissue & cell 2026 Apr;99:103263
Tissue & cell 2026 Apr;99:103263
Sequential delivery of sinigrin and dabigatran by an in situ self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration.
Hu R, Liu K, Wang W, Zhang W, Wang L, Zhang Y, Ma H, Cong M, Chi C, Cao J, Zhang B, Liu L, Meng Q, Kong X, Shi B, Li L, Cheng L, Wei Z
Materials today. Bio 2026 Apr;37:102827
Materials today. Bio 2026 Apr;37:102827
Recombinant Filaggrin-2 microneedles reverse androgenetic alopecia by rescuing mitochondrial dysfunction in dermal papilla cells.
Chang R, Hao J, Huang Z, Zhang X, Li Z, Wu Q, Tang X, Li Y, Xia H, Deng J, Yang Y, Huang Y
International journal of biological macromolecules 2026 Apr;357:151522
International journal of biological macromolecules 2026 Apr;357:151522
High-throughput screening of EGFR/Ca(2+) signaling modulators in cardiac hypertrophy using a tetrahedral DNA nanostructure-based hESC platform.
Wu KJ, Dai YF, Wang ZQ, Sun W, Zhu YN, Chen F, Shao L, Huang YY, Chen Q, Liu X, Li Y, David Wang HM, Ning Sun
Journal of pharmaceutical analysis 2026 Apr;16(4):101479
Journal of pharmaceutical analysis 2026 Apr;16(4):101479
Structure-Based Discovery of Novel, Highly Potent VEGFR2 Inhibitors with a Naphthalene Scaffold against a Broad Range of Solid Tumors.
Yang T, Wei T, Sun S, Xi B, Wei P, Jia C, Qi Z, Feng F, Wei M, Wang Y, Cai X, Zhao Z, Li B, Qiao M, Zou Y, Mu Z, Lei X, Zhang Z, Lei G, Lv K, Zheng Z, Li P, Li S
Journal of medicinal chemistry 2026 Apr 9;69(7):8340-8363
Journal of medicinal chemistry 2026 Apr 9;69(7):8340-8363
Design, synthesis, and investigation of anti-Alzheimer's activity and molecular mechanisms of phosphatidylserine derivatives.
Lin Y, Lin X, Zhu J, Li M, Xi Y, Lu D, Zhang Y, Fu L, Jiang F
European journal of medicinal chemistry 2026 Apr 5;307:118676
European journal of medicinal chemistry 2026 Apr 5;307:118676
Brucea Javanica Oil Attenuates Osteosarcoma Progression by Reprogramming Tumor-associated Macrophages via Inhibiting PI3K/AKT Pathway.
Guo Y, Jiang Y, Li Z, Zhou J, Yao N
Applied biochemistry and biotechnology 2026 Apr 28;
Applied biochemistry and biotechnology 2026 Apr 28;
Bovine serum albumin-coated metal-phenolic nanoplatform for atherosclerosis therapy via targeted delivery and inhibition of vascular smooth muscle cells proliferation.
Li N, Huang Q, Liu Y, Ren D, Liu Y, Liu X, Zhang P, Liu R
Free radical biology & medicine 2026 Apr 23;251:372-386
Free radical biology & medicine 2026 Apr 23;251:372-386
Network Toxicology and In Vivo Studies Reveal the Toxicity and Mechanisms of Tributyl Citrate Carried by Microplastics in Promoting Colitis-to-Tumorigenesis Transformation.
Chen H, Cheng Y, Zhou Y, Fu R, Jia J, Zhang S, Chen J, Cao H, Zhang P, Geng Q, Gu J, Chen B, Han W, Xiong M, Li T, Cao G
Environment & health (Washington, D.C.) 2026 Apr 17;4(4):601-617
Environment & health (Washington, D.C.) 2026 Apr 17;4(4):601-617
Panax notoginseng saponins enhance osteogenesis-angiogenesis coupling to ameliorate osteoporosis combined with intervertebral disc degeneration.
Huang F, Hu H, Chen Y, Guo W, Liu R, Chen S, Yujia S, Xu S, Zheng S, Chen Y, Zhang K, Zhang Z, Zou X, Lin S, Qian D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 16;156:158193
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 16;156:158193
CuET inhibits Ewing sarcoma of bone progression through modulation of the ESM1-MAPK/ERK signaling axis.
Xu W, Jiang Z, Peng D
International immunopharmacology 2026 Apr 15;175:116444
International immunopharmacology 2026 Apr 15;175:116444
Study of the role of transmembrane emp24 domain-containing protein 2 in oral squamous cell carcinoma.
Zhao-Wei R, Xue-Feng J, Gao-Tian X, Jin-Ling C, Jun LI, Shu-Ying LV
Journal of applied oral science : revista FOB 2025;33:e20240305
Journal of applied oral science : revista FOB 2025;33:e20240305
MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells.
Ding F, Zhang W, Liu T, Rong X, Cui Y, Meng L, Wang L, Liu B, Li M
Drug design, development and therapy 2025;19:2173-2188
Drug design, development and therapy 2025;19:2173-2188
Succinate Facilitates CD4(+) T Cell Infiltration and CCL1 Production to Promote Myofibroblast Activation and Renal Fibrosis in UUO Mice.
Tao Y, Zhang W, Liu D, Cao H, Yi X, Deng X, Li P, Shen X, Zhou H
Journal of inflammation research 2025;18:7827-7840
Journal of inflammation research 2025;18:7827-7840
Naoxintong Is Involved in the Coagulation Regulation of Warfarin Through the MAPK Pathway.
Luo X, Chen L, Xu J, Li J
Pharmacogenomics and personalized medicine 2025;18:35-46
Pharmacogenomics and personalized medicine 2025;18:35-46
Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway.
Huang X, Liu J, Wu X, Mo Y, Luo X, Yang Y, Yang C, Liang X, Liang R, Chen Y, Fan Z, Lu W, Chen Y, Hua Q
Journal of inflammation research 2025;18:1755-1772
Journal of inflammation research 2025;18:1755-1772
Silencing ATF3 mediates mitochondrial homeostasis and improves ischemic stroke through regulating the MAPK signaling pathway.
Li H, Zhang F, Zhang C, Zhou M, Liu Q, Zeng G
Frontiers in molecular neuroscience 2025;18:1554802
Frontiers in molecular neuroscience 2025;18:1554802
Network Pharmacology, Experimental Validation Explored Kakkalide to Ameliorate Endothelial Cell Dysfunction and Inflammatory Response.
Li J, Yang S, Pan J, Qin Y, Ye H, Liao S, Shao Z, Rong G, Xia Z, Sun J, Shao Y
Journal of inflammation research 2025;18:11737-11753
Journal of inflammation research 2025;18:11737-11753
CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway.
Lv H, Zhang B, Weng X, Li Y, Deng C, Wang R, Shi L, Yin Y
Breast cancer (Dove Medical Press) 2025;17:455-470
Breast cancer (Dove Medical Press) 2025;17:455-470
Extracellular vesicles-miR-205-5p inhibits lymphatic metastasis in pancreatic cancer through diffusely downregulating VEGFA.
Wang Y, Qin C, Zhao Y, Zhao B, Li Z, Li T, Zhang X, Wang W
Journal of Cancer 2025;16(7):2197-2211
Journal of Cancer 2025;16(7):2197-2211
Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models.
Chen H, Li G, Deng L, Xu N, Lee SM, Nie X, Bian JS
Frontiers in pharmacology 2025;16:1585181
Frontiers in pharmacology 2025;16:1585181
Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer.
Jansen C, McAdams J, Kim C, De La Cruz P, Salaverria A, DaSilva NA, Grive K, James NE
Frontiers in pharmacology 2025;16:1547164
Frontiers in pharmacology 2025;16:1547164
Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma.
Fu X, Huang J, Chen X, Xie D, Chen H, Liang Z, Wang Z, Liang Y, Lu A, Liang C
Theranostics 2025;15(1):103-121
Theranostics 2025;15(1):103-121
ATP1B3 may promote glioma proliferation and migration through MAPK/NF-KB signaling pathway.
Yan Q, Sun Q, Feng Y, Hu Q, Zhu J
Frontiers in oncology 2025;15:1537687
Frontiers in oncology 2025;15:1537687
Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone.
Zheng Z, Tan J, Chen M, Zhang X, Liu S, Wen Y, Long L, Zhou C, Li Y
Frontiers in cell and developmental biology 2025;13:1647476
Frontiers in cell and developmental biology 2025;13:1647476
Zirconia/dental pulp stem cell composite scaffolds repair osteogenic defect via regulating macrophages.
Wu Y, He M, Li C, Shang W, Hu J, Liu B
Frontiers in bioengineering and biotechnology 2025;13:1632000
Frontiers in bioengineering and biotechnology 2025;13:1632000
Fibroblast growth factor 19 regulates polycystic ovary syndrome progression via FGFR4-ERK-NRF2 pathway.
Qu J, Qiu M, Wang J, Chen Z, Chen M, Teng X, Li Y
Frontiers in cell and developmental biology 2025;13:1626938
Frontiers in cell and developmental biology 2025;13:1626938
Suyin Detoxification Prescription Regulates the Klotho and ERK/NF-κB Signaling Pathways to Alleviate Renal Injury.
Shu L, Quan L, Wang Y, Chen Y, Yong C, Tian F, Gao K, Zhou E
Cell biochemistry and biophysics 2025 Sep;83(3):3137-3152
Cell biochemistry and biophysics 2025 Sep;83(3):3137-3152
TUFT1 Modulates Cell Proliferation, Migration, Invasion, Stemness and EGFR Signaling in Cervical Cancer through Interacting with and Targeting ATF1.
Han C, Gao H, Li F, Lin L, Qian M, Feng L
Cell biochemistry and biophysics 2025 Sep;83(3):2881-2894
Cell biochemistry and biophysics 2025 Sep;83(3):2881-2894
Alpha-enolase promotes progression of acute myeloid leukemia via MAPK/ERK signaling pathway.
Zhang S, Wang H, Zhang X, Kui X, Huang D, Qin M, Liu S, Sun MZ, Yan J
Blood science (Baltimore, Md.) 2025 Sep;7(3):e00246
Blood science (Baltimore, Md.) 2025 Sep;7(3):e00246
Up-regulation of NGEF via the BRAF(V600E) /ERK/AP1 pathway enhances invasion and migration abilities of BRAF(V600E)-mutant thyroid cancer.
Fu Z, Wang Y, Wang CJ, Yu Z, Chen JQ
Biochemistry and biophysics reports 2025 Sep;43:102164
Biochemistry and biophysics reports 2025 Sep;43:102164
Mycobacterium tuberculosis Rv2521 promotes ferroptosis-dependent pathogenicity by inhibiting NF-κB activation.
Liu W, Zhu C, Zhang L, Wang Y, Zhang X, Shang X, Zhao J, Li Z, Jia H, Zhang Z, Pan L
International journal of biological macromolecules 2025 Sep;321(Pt 4):146294
International journal of biological macromolecules 2025 Sep;321(Pt 4):146294
Ovotransferrin ameliorated intestinal barrier dysfunction in DSS-induced ulcerative colitis mice via inhibition of PI3K-Akt/MAPK signaling pathways and modulation of tissue metabolism.
Zheng D, Ma L, Xin X, Gao Y, Dong S, Huang Y, Wu J, Huo J, Li S
International journal of biological macromolecules 2025 Sep;321(Pt 1):146274
International journal of biological macromolecules 2025 Sep;321(Pt 1):146274
TMI, an isoflavone from the fruits of Ficus altissima Blume, overcomes K562/ADR leukemia cells resistance by targeting Nrf2.
Shen L, Xu J, Wang Y, Yao J, He X
Fitoterapia 2025 Sep;185:106688
Fitoterapia 2025 Sep;185:106688
Naringenin: A potential therapeutic agent for modulating angiogenesis and immune response in hepatocellular carcinoma.
Wu W, Qiu X, Ye X, Zhang Z, Xu S, Yao X, Du Y, Wu G, Zhang R, Zhu J
Journal of pharmaceutical analysis 2025 Sep;15(9):101254
Journal of pharmaceutical analysis 2025 Sep;15(9):101254
Peroxisome Proliferator-Activated Receptor Gamma (PPARγ)-targeted Gel/Mg/Lip@Gigantol nanoplatform attenuates skin barrier disruption-associated aging in mice via NLRP3 suppression.
Jia X, Yuan R, Huang Y, Li X, Zhang R, He L, Yang Z
International journal of biological macromolecules 2025 Sep 5;328(Pt 1):147464
International journal of biological macromolecules 2025 Sep 5;328(Pt 1):147464
Uncovering key anti-inflammatory constituents and mechanism of Wuwei Xiaodu Decoction by a combined strategy of phytochemistry, AIDD, network pharmacology, and in vitro and in vivo assay.
Li B, Zhou Z, Zhang Y, Zhu J, Liu Q, Ma J, Gong Z, Xu Z, Shen J, Zhu W, Chen J
BMC complementary medicine and therapies 2025 Sep 30;25(1):344
BMC complementary medicine and therapies 2025 Sep 30;25(1):344
Comparison of Quercetin and Isoquercitrin's Anti-Heart Failure Activity via MAPK Inflammatory Pathway and Caspase Apoptosis Pathway.
Guo A, Chen X, Bai Y, Dai Y, Yue H
Pharmaceuticals (Basel, Switzerland) 2025 Sep 26;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 26;18(10)
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics.
Rao Z, Chen Z, Bao Y, Lu Z, Tang Y, Zhu J, Ma J, Dong S, Shi J, Sheng S, Chen Y, Wang J, Mukondiwa AV, Li Z, Wang X, Huang Z, Li C, Ding W, Chen M, Han Z, Wang C, Pan X, Wang X, Zhu H, Lin L, Huang Z, Lu W, Li X, Luo Y
Signal transduction and targeted therapy 2025 Sep 26;10(1):315
Signal transduction and targeted therapy 2025 Sep 26;10(1):315
Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis.
Wang L, Fu Z, Su Y, Yin W, Wang X, Zhao W, Wang J, Li Y, Liu N, Su W, He L, Yin S, Wang Y, Yang X
Journal of medicinal chemistry 2025 Sep 25;68(18):19503-19520
Journal of medicinal chemistry 2025 Sep 25;68(18):19503-19520
SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer.
Zhou X, Wang G, Wu Y, Wu M, Zhai X, Tian C, Prochownik EV, Jiang C, Li Y
Cell reports 2025 Sep 23;44(9):116139
Cell reports 2025 Sep 23;44(9):116139
Kuwanon A Targeted YWHAB in Hepatocellular Carcinoma Cells to Inhibit the Raf/MEK/ERK Signaling Pathway.
Xu J, Chang H, Wang Y, Du Y, Zhong L, Cui H
Cells 2025 Sep 23;14(19)
Cells 2025 Sep 23;14(19)
Bisphenol A promotes OSCC progression via GABBR1-mediated MAPK signaling and macrophage polarization: A network toxicology based study.
He Q, Ma A, Yang Z, Pang X, Li C, Diao J, Liu Y, Liu Q, Zhang Q, Dong Z, Zhang D
Ecotoxicology and environmental safety 2025 Sep 15;303:118835
Ecotoxicology and environmental safety 2025 Sep 15;303:118835
Bushen Jiangu decoction alleviates osteoporosis by inhibiting MMP2 expression and activation of the MAPK pathway in vitro.
Chen P, Lin J
Tissue & cell 2025 Oct;96:103025
Tissue & cell 2025 Oct;96:103025
Self-propelled gas nanomotor-integrated microneedles for melanoma therapy: Dual-action in situ eradication and metastatic suppression.
Lee C, Huang S, Liu H, He X, Hao Y, Zeng L, Li Y, Lv Z, Xu Y, Guo R
Materials today. Bio 2025 Oct;34:102122
Materials today. Bio 2025 Oct;34:102122
Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice.
Yu C, Cai L, Zhuang L, Wu Y, Wu Q, Liang H, Shi M, Miao J, Song H, Jin H, Pan Y
Free radical biology & medicine 2025 Oct;238:206-219
Free radical biology & medicine 2025 Oct;238:206-219
Critical role of the β isoform of protein kinase C (PKCβ) in angiotensin II-induced oxidative stress in vascular smooth muscle cells.
Tajima H, Naganishi S, Mukohda M, Ishida M, Hamada N, Shigemi N, Yamasaki T, Nakamura S, Matsui T, Mizuno R, Ozaki H
Physiological reports 2025 Oct;13(20):e70595
Physiological reports 2025 Oct;13(20):e70595
Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinoma.
Lin X, Chen W, Li B, Zhao Z, Yu Z, Zhao XY, Zhou X, Feng Z, Lin C, Cao W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e17795
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e17795
TSN Disrupts Fanconi Anemia Pathway Activation Through JAK/STAT1-Mediated Transcriptional Repression of FA Core Subunits in Bladder Cancer.
Zhao W, Xie Z, Zhu L, Li W
Dose-response : a publication of International Hormesis Society 2025 Oct-Dec;23(4):15593258251406039
Dose-response : a publication of International Hormesis Society 2025 Oct-Dec;23(4):15593258251406039
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway.
Yan S, Liu J, Zhang T, Li J, Zeng J, Li M, Aslam MS, Shen J, Tong T, You Z, Liu S, Li P, Li J, Gong K, Wei S, Hao C, Meng X
Molecular brain 2025 Oct 8;18(1):77
Molecular brain 2025 Oct 8;18(1):77
Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
Huo N, Xu G, Zhou H, Liu Y, Li S, Yang X, Liu J, Wang W, Yang N, Zhou N
ACS applied materials & interfaces 2025 Oct 8;17(40):55876-55894
ACS applied materials & interfaces 2025 Oct 8;17(40):55876-55894
Non canonical BRCA1 promotes cell survival via modulating PARP13-mediated SEC61G mRNA decay.
Sun B, Li Y, Wu Y, Wang C, Zhu J, Zhang W, Li D, Que W, Chen G
Oncogenesis 2025 Oct 6;14(1):35
Oncogenesis 2025 Oct 6;14(1):35
OTSSP167 suppresses TNBC brain metastasis via ROS-driven P38/JNK and FAK/ERK pathways.
Tang D, Xu C, Jiang Z, Meng Z, Zhang M, Fan F, Liu H
European journal of pharmacology 2025 Oct 5;1004:178017
European journal of pharmacology 2025 Oct 5;1004:178017
Trem2-MICAL1-P-ERK Axis in Macrophages Confers Protection Against Toxoplasma gondii-Induced Adverse Pregnancy Outcomes.
Geng X, Yang H, Wang Z, Chen Z, Chen J, Yang M
Pathogens (Basel, Switzerland) 2025 Oct 30;14(11)
Pathogens (Basel, Switzerland) 2025 Oct 30;14(11)
The SP1-SuperEnhancer-SPHK1 Axis Mediates Niraparib Resistance in TNBC.
Yuan YX, Chen RJ, Tu GH, Li CQ, Xu LL, Lu YL, Wu LX
Pharmaceuticals (Basel, Switzerland) 2025 Oct 27;18(11)
Pharmaceuticals (Basel, Switzerland) 2025 Oct 27;18(11)
Preconception paternal exposure to zearalenone impairs male fertility and IVF embryo survival in mice.
Wang P, Chen Y, Jiao Y, Zhu Y, Wang M, Ji D, Zou W, Cao Y, Liu Y, Liang D
Chemico-biological interactions 2025 Oct 22;420:111646
Chemico-biological interactions 2025 Oct 22;420:111646
PTPN2 acts as a tumor suppressor and therapeutic target in ovarian cancer.
Sun X, Zhang W, Wang H, Hao J, Shi W, Lei P, Wei G, Liu Y, Xu C, Li L, Yu L, Zhang DL
Biochemical and biophysical research communications 2025 Oct 20;785:152704
Biochemical and biophysical research communications 2025 Oct 20;785:152704
GPR30-mediated the MEK/ERK signaling pathway promotes porcine oocyte maturation and development.
Duan J, Xu A, Xie J, Wang L, Lv Q, Yang J, Zhao N, Li B, Cao G
Theriogenology 2025 Oct 15;246:117537
Theriogenology 2025 Oct 15;246:117537
Bacteroides vulgatus alleviates heart failure via butyric acid-TGF-β1/MAPK pathway.
Du Z, Zhang W, Wang Y, Fang X, Zhang Y, Xiao Y, Zeng X, Yuan S, Jiang Y, Guo X, Hua K, Yang X, Zhao X, Liu Y, Lu Y, Tu P
Journal of advanced research 2025 Oct 14;
Journal of advanced research 2025 Oct 14;
PDLIM4 drives gastric cancer malignant progression and cisplatin resistance by inhibiting HSP70 ubiquitination and degradation via competitive interaction with STUB1.
Zhu C, Chen M, Fan L, Wang Y, Liu M, Kang G, Yin F, Tang H, He Y, Zhang S, Zeng L, Liu W, Yu K, Le A
Journal of nanobiotechnology 2025 Oct 11;23(1):661
Journal of nanobiotechnology 2025 Oct 11;23(1):661
Crinis Carbonisatus-Derived Carbon Dot Suspension Alleviates Temporal Lobe Epilepsy.
Huang Y, Li M, Dong L, He C, Zou P, Xia M, Jin B, Wang S, Lu Z, Qu H, Zhang Y, Kong H
Pharmaceuticals (Basel, Switzerland) 2025 Oct 1;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Oct 1;18(10)
Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.
Qiu H, Cai C, Zhang Y, Yang S, Hu X, Chu T
Phytotherapy research : PTR 2025 Nov;39(11):4977-4990
Phytotherapy research : PTR 2025 Nov;39(11):4977-4990
Bispecific aptamers target thyrotropin receptor (TSHR) and insulin growth factor-1 receptor (IGF-1R) for the improvement of orbital fibroblasts activation in the treatment of thyroid-associated ophthalmopathy.
Xie B, Zhang F, Yin J, Ouyang S, Cao J, Tan Y, Xiong W
International journal of biological macromolecules 2025 Nov;330(Pt 1):147867
International journal of biological macromolecules 2025 Nov;330(Pt 1):147867
The β-glucan from Lentinus alleviates UVB-induced dermal fibroblasts senescence and skin photoaging.
Wei K, He L, Li X, Wu M, Wang H, Hu L, Xu H, Zhang Y, Zhou L, Xu X, Guo L
International journal of biological macromolecules 2025 Nov;329(Pt 2):147834
International journal of biological macromolecules 2025 Nov;329(Pt 2):147834
Polystyrene nanoplastics impair endometrial decidualization via cell cycle arrest and JNK-MAPK pathway-mediated oxidative stress in early pregnant mice.
Li JA, Wang LQ, Xu QJ, Wu XM, Pang XQ, He JX, Qiao QF, You HN, Wu YC, Zhou YJ
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Nov;205:115707
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Nov;205:115707
SIN1 facilitates glioma progression and is associated with the KRAS/ERK pathway.
Cao H, Yan Z, Li M, Wang J, Zhang H, Cheng Y, Sun J, Ren J, Yang D
Journal of neuro-oncology 2025 Nov;175(2):697-711
Journal of neuro-oncology 2025 Nov;175(2):697-711
Exploration of new azole derivatives containing ethanolamine moiety as anti-UC agents by inhibiting NF-κB/MAPK pathways.
Ju MQ, Huang ZX, Mo QY, Liu S, Wang DX, Li YP, Wan CP, Mao ZW
Molecular diversity 2025 Nov 6;
Molecular diversity 2025 Nov 6;
Scutellarin Protects Retinal Ganglion Cells in Glaucoma by Targeting the Hsp90aa1-MAPK Pathway to Inhibit Apoptosis.
Su JZ, Wang J, Gao ZL, Ding L, Xia XB
Investigative ophthalmology & visual science 2025 Nov 3;66(14):44
Investigative ophthalmology & visual science 2025 Nov 3;66(14):44
Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression.
Li Y, Xu L, Lu X, Fu B, Jiang Q, Xiong W, Tang W, Wu D
Digestive diseases and sciences 2025 Nov 29;
Digestive diseases and sciences 2025 Nov 29;
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Bian WH, Wang SH, Kang ZC, Xu Y, Li YN, Yang MZ, Yang JH, Liu JY, Cheng YL, Chang D, Xie X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Integrated analysis of Corylin from Psoralea Corylifolia inhibiting osteoporosis via MAPK pathway.
Liu N, Yang Z, Yanzhang R, Shen R, Yi W, Teng J
Scientific reports 2025 Nov 19;15(1):40724
Scientific reports 2025 Nov 19;15(1):40724
MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics.
Wei J, Mao R, Chen Y, Si K, Li Y, Li J, Zhu W
Cell death & disease 2025 Nov 17;16(1):832
Cell death & disease 2025 Nov 17;16(1):832
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.
Yang H, Shen T, Qi Z, Yang Z, Zhang M, Jiang J, Sun Z, Lu C
Neuropharmacology 2025 Nov 15;279:110638
Neuropharmacology 2025 Nov 15;279:110638
FGF21 Exhibits Neuroprotective Effects by Promoting 5-HT(1A)R-FGFR1 Heteroreceptor Complexes and Triggering MEK(1/2)-ERK(1/2) Signaling Pathway.
Yan Q, Li XJ, Wang QQ, Jia W, Wang SL
Molecular neurobiology 2025 May;62(5):6369-6382
Molecular neurobiology 2025 May;62(5):6369-6382
Oleracein E Rejuvenates Senescent Hippocampal NSCs by Inhibiting the ERK1/2-mTOR Axis to Improve Cognitive Dysfunction in Vascular Dementia.
Lang H, Zeng J, Wen Y, Xu J, Xiao R, Shi Y, Lu Q, Xia X, Hu G
The European journal of neuroscience 2025 May;61(9):e70137
The European journal of neuroscience 2025 May;61(9):e70137
Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure.
Tong L, Wang Q, Zhang Y, Lai F, Xu J, Yin W, Zhang S, Wei G, Yin J, Yi H, Storm G, Wang Z, Huang R, Xu T, Wang JW
Biomaterials 2025 May;316:122976
Biomaterials 2025 May;316:122976
Lipocalin 2 Facilitates the Initial Compromise of the Blood-Brain Barrier Integrity in Chronic Cerebral Hypoperfusion.
Nie Q, Zhang L, Gu Z, Li Y, Bi X
CNS neuroscience & therapeutics 2025 May;31(5):e70438
CNS neuroscience & therapeutics 2025 May;31(5):e70438
An exploration on the involvement of the methyltransferase like 3-m(6)A‑zinc finger MYM-type containing 1 axis in the progression of liver hepatocellular carcinoma.
Chen W, Meng Y, Zhan S, Xiong F, Wang L, Yao J
International journal of biological macromolecules 2025 May;309(Pt 4):142820
International journal of biological macromolecules 2025 May;309(Pt 4):142820
Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells.
Wang Q, Wang S, Cui L, Zhang Y, Waterhouse GIN, Sun-Waterhouse D, Ma C, Kang W
International journal of biological macromolecules 2025 May;309(Pt 3):142985
International journal of biological macromolecules 2025 May;309(Pt 3):142985
Lentinan alleviates angiotensin II-induced myocardial remodeling through LMP7-SOCS3 signaling.
Pan Y, Chen B, Xie J, Chen D, Cai Y, Zhao D, Cao Y, Lian F, Yan X
International journal of biological macromolecules 2025 May;308(Pt 3):142146
International journal of biological macromolecules 2025 May;308(Pt 3):142146
The Potential Hepatocyte Differentiation Targets and MSC Proliferation by FH1.
Luo S, Wu F, Jin Y, Liu D
Journal of cellular and molecular medicine 2025 May;29(9):e70601
Journal of cellular and molecular medicine 2025 May;29(9):e70601
Hypoglycemic effect of dietary fibers from Moringa oleifera leaves: In vitro and in vivo studies.
Li X, Yong J, Zhao B, Zhu Y, Luo J, Sheng J, Tian Y
Food research international (Ottawa, Ont.) 2025 May;209:116196
Food research international (Ottawa, Ont.) 2025 May;209:116196
10-Hydroxydec-2-enoic acid reduces vascular smooth muscle cell inflammation via interacting with Toll-like receptor 4.
Jia F, Wang Y, Chen Z, Jin J, Zeng L, Zhang L, Tang H, Wang Y, Fan P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156534
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156534
Rilmenidine attenuates intracerebral hemorrhage by regulating autophagy flux and apoptosis via the HO-1/Fe(2+)/ERK pathway.
Hua Q, Lu M, Li Z, Song P, Gao L, Zhou L, Zhang J, Cai Q
Neuroscience 2025 May 7;573:382-398
Neuroscience 2025 May 7;573:382-398
Melatonin Promotes Osteogenic Differentiation of Rat Adipose-Derived Stem Cells via the p38/MAPK Signaling Pathway.
Meng S, Han S, Kong M, Liu Z, Lin A, Qu C, Li L, Ma X, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70647
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70647
Mineralocorticoid receptor antagonism attenuates arteriovenous fistula stenosis by modulating the phenotype of vascular smooth muscle cells.
Liu Y, Chen B, Chen K, Wang Y, Zhou C, Liang X, Wang K, Wang P
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2025 May 30;40(6):1124-1136
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2025 May 30;40(6):1124-1136
ShenJiaoLingCao decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism.
Liu Y, Wu Z, Gu C, Fang J, Peng Y, Peng L, Chen W, Yao L, He L
Journal of ethnopharmacology 2025 May 28;348:119830
Journal of ethnopharmacology 2025 May 28;348:119830
Mechanism of the Proprietary Chinese Medicine "JiuLiWan" to Treat Ulcerative Colitis Revealed by Network Pharmacology, Molecular Docking, and Experimental Verification In Vitro.
Liao Z, Liu X, Li L, Li S, Xing X, Zheng X, Song W, Gui P, Liu Q, Rong G, Shao Y, Zou M, Liao H, Wu X
ACS omega 2025 May 20;10(19):19598-19613
ACS omega 2025 May 20;10(19):19598-19613
LncRNA NEAT1 participates in diminished ovarian reserve by affecting granulosa cell apoptosis and estradiol synthesis via the miR-204-5p/ESR1 axis.
Dong L, Wu H, Qi F, Chen W, Xu Y, Li M, Wang Y, Yan R, Cai P
Journal of ovarian research 2025 May 16;18(1):102
Journal of ovarian research 2025 May 16;18(1):102
Basal and AT2 cells promote IPF-lung cancer co-occurrence via EMT: Single-cell analysis.
Ren C, Zi Y, Zhang X, Liao X, Chen H
Experimental cell research 2025 May 15;448(2):114578
Experimental cell research 2025 May 15;448(2):114578
Modified weiling decoction inhibited excessive autophagy via AKT/mTOR/ULK1 pathway to alleviate T2DM: Integrating network pharmacology and experimental validation.
Gao W, Wang M, Xu W, Ma R, Wang X, Sun T, Li P, Li F, He Y, Xie X, Pang X, Zhou Y, Pang G
Journal of ethnopharmacology 2025 May 12;347:119753
Journal of ethnopharmacology 2025 May 12;347:119753
LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway.
Pang X, Zhang T, Li J, Yu L, Liu Z, Liu Y, Li L, Cheng L, Zhu R
Biomaterials 2025 Mar;314:122873
Biomaterials 2025 Mar;314:122873
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Li S, Yin Y, Dong X, Xu L, Yang Z, Li H, Zou Y, Wu Z
Biological trace element research 2025 Mar;203(3):1539-1554
Biological trace element research 2025 Mar;203(3):1539-1554
SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells.
Wang L, Song J, Yang Z, Zhang H, Wang Y, Liu J, Wang S, Shi J, Tong X
Journal of molecular and cellular cardiology 2025 Mar;200:68-81
Journal of molecular and cellular cardiology 2025 Mar;200:68-81
The protective effect and potential mechanism of Zanthoxylum bungeanum Maxim. on atherosclerosis.
Li Z, Xu R, Li C, Chi C, Yang X, Yang S, Liu R
Fitoterapia 2025 Mar;181:106394
Fitoterapia 2025 Mar;181:106394
ELF5 gene promotes milk lipid synthesis in goat mammary epithelial cells by transcriptomic analysis.
Ma C, Guo Y, Tu T, Cui S, Zhong J, Zhang Y, Song N, Liu H
Genomics 2025 Mar;117(2):111023
Genomics 2025 Mar;117(2):111023
Exosomal integrin alpha 3 promotes epithelial ovarian cancer cell migration via the S100A7/p-ERK signaling pathway.
Yin Z, Ma J, Adu-Amankwaah J, Xie G, Wang Y, Tai W, Sun Z, Huang C, Chen G, Fu T, Zhang B, Zhou X
Acta biochimica et biophysica Sinica 2025 Mar 7;57(6):1006-1019
Acta biochimica et biophysica Sinica 2025 Mar 7;57(6):1006-1019
Network pharmacology and in vivo study: Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis.
Qin Y, Zhang RY, Zhang Y, Zhao YQ, Hao HF, Wang JP
World journal of gastroenterology 2025 Mar 7;31(9):100271
World journal of gastroenterology 2025 Mar 7;31(9):100271
FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD(+) acute myeloid leukemia.
Zhou Q, Li Z, Zhao P, Guan Y, Chu H, Xi Y
Oncogenesis 2025 Mar 29;14(1):7
Oncogenesis 2025 Mar 29;14(1):7
Ginsenoside 1 mitigates postoperative cognitive dysfunction by enhancing microglial Aβ clearance through the endo-lysosomal pathway.
Jing X, Zhao Y, Wang G, Tian W
International immunopharmacology 2025 Mar 26;150:114281
International immunopharmacology 2025 Mar 26;150:114281
Identification of therapeutic targets and immune landscape in glioblastoma through crosstalk with glioma-associated mesenchymal stem cells.
Zheng H, Wang H, Zhang D, Gan Y, Wu Y, Xiang W, Fu P
International immunopharmacology 2025 Mar 26;150:114228
International immunopharmacology 2025 Mar 26;150:114228
Integration analysis of miRNA-mRNA uncovers the mechanisms of ochratoxin A-induced hepatotoxicity.
Luo Z, Jin R, Pan F, Guo R, Li M, Zhang S, Shi J, Zheng J, Wang H, Yang X, Yang J, Yu G
Ecotoxicology and environmental safety 2025 Mar 15;293:118039
Ecotoxicology and environmental safety 2025 Mar 15;293:118039
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
Li XJ, Zhang MC, Li X, Guan LL, Liang YR, Hao EJ, Wang Y, Guo HM
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes.
Li J, Li S, Sun Q, Li L, Zhang Y, Hua Z
Journal of neuroinflammation 2025 Mar 12;22(1):76
Journal of neuroinflammation 2025 Mar 12;22(1):76
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Fu X, Zhang Q, Chen Y, Li Y, Wang H
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway.
Weijia LI, Jing LU, Chao MA, Mengmeng L, Ke P, Hongyan C, Zhe L, Guangfu L
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):493-507
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):493-507
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
Ma Z, Xu Y, Lian P, Wu Y, Liu K, Zhang Z, Tang Z, Yang X, Cao X
Neuroscience bulletin 2025 Jun;41(6):951-969
Neuroscience bulletin 2025 Jun;41(6):951-969
Exosomes derived from myelodysplastic syndromes cells induce IL-1β production from macrophages to promote disease progress.
Li P, Guan D, Li S, Deng J, Zhang H, Liu X, Chen X, Xu Z, Wang H, Ren F
Cytokine 2025 Jun;190:156924
Cytokine 2025 Jun;190:156924
The key active ingredients identification and pharmacological mechanism investigation of extract of ethyl acetate from Er Miao San aganist rheumatoid arthritis.
Wang JY, Tang R, Chen SM, Su WR, Wang J, Qin ZF, Yin JH, Xuan ZH, Zhao HS, Zhang M, Zhang W, Jia XY
Fitoterapia 2025 Jun;183:106534
Fitoterapia 2025 Jun;183:106534
ULBP2 promotes progression of head and neck squamous cell carcinoma by modulating MAPK signaling pathway.
Xu W, Liu S, Yang W
Journal of stomatology, oral and maxillofacial surgery 2025 Jun;126(3S):102204
Journal of stomatology, oral and maxillofacial surgery 2025 Jun;126(3S):102204
Luteolin ameliorates kainic acid-induced seizure by modulating GADD45B and reducing oxidative stress in hippocampal neurons.
Luo C, Wang Z, Liao J, Fu C, Zhang F, Zhao J
Neuropeptides 2025 Jun;111:102524
Neuropeptides 2025 Jun;111:102524
LRP1 regulates asthmatic airway smooth muscle proliferation through FGF2/ERK signaling.
Deng Y, Zhao J, Gong C, Ding W, Fang L, Liu H, Li M, Shen B, Ding S
JCI insight 2025 Jun 9;10(11)
JCI insight 2025 Jun 9;10(11)
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
Chen Y, Yan Q, Ruan S, Cui J, Li Z, Zhang Z, Yang J, Fang J, Liu S, Huang S, Hou B, Zhang C
Cell reports 2025 Jun 24;44(6):115774
Cell reports 2025 Jun 24;44(6):115774
Resveratrol exerts antiviral activity against pseudorabies virus through regulation of the OPN-ERK/JNK-IL-1β signaling axis.
Luan H, Song Y, Hu H, Zhang W, Zhang H, Su T, Wang J, Ye G, Yin Z, Zhao X, Zhou X, Li L, Zou Y, Zhang Y, Song X
Journal of proteomics 2025 Jun 15;317:105444
Journal of proteomics 2025 Jun 15;317:105444
Polystyrene nanoplastics aggravate house dust mite induced allergic airway inflammation through EGFR/ERK-dependent lung epithelial barrier dysfunction.
Wang Q, He W, Zhou Y, Feng R, Wang Y, Liu L, Yuan Y, Dai J, Liu Y, Zhang X
Ecotoxicology and environmental safety 2025 Jun 15;298:118329
Ecotoxicology and environmental safety 2025 Jun 15;298:118329
Sea Cucumber Fucoidan Inhibits Helicobacter pylori Gastritis via MAPK/NF-κB Signaling and Gut Microbiota Modulation.
Cao J, Yao M, Wang K, Qin L, Zhang Q, Zhang H, Wei J, Qu C, Xue C, Miao J
Journal of agricultural and food chemistry 2025 Jun 11;73(23):14333-14352
Journal of agricultural and food chemistry 2025 Jun 11;73(23):14333-14352
PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma.
Cui M, Ding X, Jiang Y, Zhang L, Cao W, Wang Y, Sheng Z, Sun W, Guo A, Gu L, Zhang X, Duan W, Shi L, Zhang B
Acta biochimica et biophysica Sinica 2025 Jun 11;57(10):1625-1635
Acta biochimica et biophysica Sinica 2025 Jun 11;57(10):1625-1635
CDC42 Regulates the ERK Pathway to Improve Oxygen‒Glucose Deprivation/Reoxygenation-Induced Neural Oxidative Stress and Apoptosis.
Hao L, Jia H, Wei F, Zhang J, Zhang J, Guo C, Wang L
Molecular neurobiology 2025 Jul;62(7):8718-8727
Molecular neurobiology 2025 Jul;62(7):8718-8727
Asperosaponin VI Promotes Osteoporotic Fracture Healing by Targeting Piezo1 to Enhance the Coupling of LEPR(+) BMSCs and PODXL(+) ECs.
Dong R, Wei J, Tian S, Ma Y, Wang J, Tu X, Li G, Liu Y
Phytotherapy research : PTR 2025 Jul;39(7):3148-3166
Phytotherapy research : PTR 2025 Jul;39(7):3148-3166
JNK signaling dominance in hyperthermia.
Enomoto A, Fukasawa T
Cell stress & chaperones 2025 Jul;30(4):100080
Cell stress & chaperones 2025 Jul;30(4):100080
Different neutrophil extracellular trap related Ewing sarcoma subtypes exhibit distinct prognosis, and immune microenvironment characteristics.
Li S, Hou Y, Zhang L, Zhang H, Wang C
Scientific reports 2025 Jul 8;15(1):24523
Scientific reports 2025 Jul 8;15(1):24523
Multi-omics study reveals gut microbiota dysbiosis and tryptophan metabolism alterations in GH-PitNET progression.
Liu J, Ye Z, Zhang Y, You S, Sun S, Lu L, Su W, Liu J, Pu J, Pan H, Zhu H, Deng K, Yao Y, Hu X, Zhang S
Scientific reports 2025 Jul 7;15(1):24261
Scientific reports 2025 Jul 7;15(1):24261
Annexin A2: regulating glioma's fate and a potential therapeutic target.
Liu W, Zhao X, Regmi M, Shamsutdinova MI, Shamsutdinov M, Liu S, Dai Y, Wang Y, Liu H, Wu J, Yang J, Yang C, Sino-Uzbek Regenerative Therapy Consortium (SURE)
Medical oncology (Northwood, London, England) 2025 Jul 28;42(9):386
Medical oncology (Northwood, London, England) 2025 Jul 28;42(9):386
Discovery of a Novel EGFR PROTAC Degrader against C797S Resistance Mutation with Potent Antitumor Efficacy in NSCLC Treatment.
Wang X, Wang C, Ma Y, Piao Y, Shi Y, Yang S, Li J, Fan Y
Journal of medicinal chemistry 2025 Jul 24;68(14):14569-14593
Journal of medicinal chemistry 2025 Jul 24;68(14):14569-14593
Suppression of the HSP90-HIF1α pathway with SNX2112-encapsulated nano-micelles for effective triple-negative breast cancer photothermal combined photodynamic therapy.
Zhang Z, Tian F, Lai S, Xu X, Zhou M, Hou Z, Li S, Zhang J, Yang X, Xie J, Ju S
Journal of materials chemistry. B 2025 Jul 2;13(26):7753-7768
Journal of materials chemistry. B 2025 Jul 2;13(26):7753-7768
Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development.
Huang Z, Fang J, Lin L, Cai N, Chen S, He G, Cao Y, Wu G, Wang Y, Li W, Huang Z, Saw PE
Journal of nanobiotechnology 2025 Jul 18;23(1):524
Journal of nanobiotechnology 2025 Jul 18;23(1):524
Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1.
Xiao S, Wei T, Xiao M, Shan M, An Z, Li N, Zhou J, Zhao S, Lu X
Antioxidants (Basel, Switzerland) 2025 Jul 14;14(7)
Antioxidants (Basel, Switzerland) 2025 Jul 14;14(7)
FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise.
Mao MZ, Zheng MH, Guo B, Ling YL, Lin X, Li FX, Shan SK, Dai DX, Qiu L, Cai XY, Ding Y, Gu YY, Deng QR, Zhou ZA, Lei LM, Tao C, Cui RR, Wu F, Zhang F, Wu B, Liao LL, Tan CM, Liao XB, Yuan LQ, Xu F
Journal of nanobiotechnology 2025 Jul 12;23(1):504
Journal of nanobiotechnology 2025 Jul 12;23(1):504
Non-canonical activation of MAPK signaling by the lncRNA ASH1L-AS1-encoded microprotein APPLE through inhibition of PP1/PP2A-mediated ERK1/2 dephosphorylation in hepatocellular carcinoma.
Zhao L, Si K, Luo S, Zhang L, Mao S, Zhang W
Journal of experimental & clinical cancer research : CR 2025 Jul 11;44(1):200
Journal of experimental & clinical cancer research : CR 2025 Jul 11;44(1):200
Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models.
Chen H, Li G, Deng L, Li S, Huang S, Lee SM, Nie X, Bian JS
Biological research 2025 Jul 10;58(1):48
Biological research 2025 Jul 10;58(1):48
Hydrogel system with growth cone-targeted hydroxyapatite nanorods: Regulating calcium signals for peripheral nerve injury repair.
Li Z, Tang X, Yang H, Lu L, Zhang J, Liu Y
Acta biomaterialia 2025 Jul 1;201:171-186
Acta biomaterialia 2025 Jul 1;201:171-186
Harmine exerts anticancer effects through the ROS/p38 axis to induce autophagy and apoptosis in osteosarcoma.
Yu L, Bi K, Gu J, Yu Z, Li S, Chen Y
Bioorganic chemistry 2025 Jul 1;161:108557
Bioorganic chemistry 2025 Jul 1;161:108557
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Fan Y, Wu H, Yin D, Liu Q, Yuan C, Zhong T, Xia B, Xiong L, Li Y, Zeng L, Li Y, Li Y, Tang L
Bioorganic chemistry 2025 Jul 1;161:108547
Bioorganic chemistry 2025 Jul 1;161:108547
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming in muscle fiber-type specification and transformation.
Tan B, Hong L, Xiao L, Wu J, Lu G, Wang S, Liu L, Zheng E, Cai G, Li Z, Gu T, Wu Z
Nature communications 2025 Jul 1;16(1):5833
Nature communications 2025 Jul 1;16(1):5833
Oxymatrine antagonises oxidative stress and apoptosis in Nemopilema nomurai toxin-induced cardiotoxicity by inhibiting mitogen-activated protein kinase.
Wang X, Wang Y, Geng X, Wang Z, Zhang J, Liu T, Chen W, Yang J, Xiao L, Dong W
Toxicology letters 2025 Jan;403:120-131
Toxicology letters 2025 Jan;403:120-131
Role of semaphorin7A in epithelial-mesenchymal transition and proliferative vitreoretinopathy.
Song S, Yang R, Su Y, Wang F
Experimental eye research 2025 Jan;250:110153
Experimental eye research 2025 Jan;250:110153
ARL11 knockdown alleviates spinal cord injury by inhibiting neuroinflammation and M1 activation of microglia in mice.
Zhang H, Xiang L, Yuan H, Yu H
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167522
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167522
Vitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR.
Wu Z, Ye Q, Zhang S, Hu LP, Wang XQ, Yao LL, Zhu L, Xiao SY, Duan ZH, Zhang XL, Jiang SH, Zhang ZG, Liu DJ, Li DX, Yang XM
Clinical and translational medicine 2025 Jan;15(1):e70191
Clinical and translational medicine 2025 Jan;15(1):e70191
Sappanone A alleviates metabolic dysfunction-associated steatohepatitis by decreasing hepatocyte lipotoxicity via targeting Mup3 in mice.
Zhu A, Yan X, Chen M, Lin Y, Li L, Wang Y, Huang J, He J, Yang M, Hua W, Chen K, Qi J, Zhou Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156341
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156341
Pimpinellin mitigates DSS-induced ulcerative colitis in mice by reducing inflammation and regulating gut microbiota.
Lv B, Hou L, Zhang H, Hao C, Song Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156308
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156308
Toosendanin alleviates acute lung injury by reducing pulmonary vascular barrier dysfunction mediated by endoplasmic reticulum stress through mTOR.
Mao X, Wang C, Tang H, Liu X, Wei C, Yin F, Fu T, Fang Y, Yu K, Zhang Z, Wu C, Liu H, Le A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156277
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156277
Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice.
Zhang S, Wang X, Liu S, Hu C, Meng Y
Brain, behavior, and immunity 2025 Jan;123:193-210
Brain, behavior, and immunity 2025 Jan;123:193-210
Halofuginone induces ERK phosphorylation and synergizes with trametinib in gastric cancer cells.
Sun Y, Wang P, Bai X, Tian L, Zhong Y
International journal of immunopathology and pharmacology 2025 Jan-Dec;39:3946320251359860
International journal of immunopathology and pharmacology 2025 Jan-Dec;39:3946320251359860
Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro.
Xu FZ, Zheng LL, Qin JB, Li YX, Chen KH, Dai LH, Zhu QL, Sang JF
Integrative cancer therapies 2025 Jan-Dec;24:15347354251339073
Integrative cancer therapies 2025 Jan-Dec;24:15347354251339073
Zinc proteinate alleviates thermal stress-induced damage to broiler jejunal organoid integrity and barrier function possibly by promoting cell proliferation via GPR39/PLCβ1-mediated PI3K/AKT and MAPK signaling pathways.
Song W, Hu Y, Zhang W, Lin X, Liu HC, Odle J, See MT, Hu Y, Li T, Wang S, Cui X, Liao X, Zhang L, Luo X
Journal of animal science 2025 Jan 4;103
Journal of animal science 2025 Jan 4;103
Revealing the molecular mechanism of baohuoside I for the treatment of breast cancer based on network pharmacology and molecular docking.
Mu J, Li Y, Chen Q, Xiao Y, Hu M, He Z, Zeng J, Ding Y, Song P, He X, Yang X, Zhang X
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118918
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118918
PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response.
Cheng L, Meliala I, Kong Y, Chen J, Proud CG, Björklund M
eLife 2025 Jan 29;13
eLife 2025 Jan 29;13
Antitumor Effects of Tryptanthrin on Colorectal Cancer by Regulating the Mitogen-Activated Protein Kinase Signaling Pathway and Targeting Topo I and IDO1.
Lu S, Hou BL, Wang T, Ma K, Huang A, Wu X, Liang YN, Wang Z
ACS omega 2025 Jan 28;10(3):3206-3221
ACS omega 2025 Jan 28;10(3):3206-3221
TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3.
Gu J, Lv YF, Xia JY, Bai FH, Gong J, Pan GQ, Liu B, Huang L, Guo QN, Hao XL
Cell & bioscience 2025 Jan 23;15(1):8
Cell & bioscience 2025 Jan 23;15(1):8
DNA-Dependent Protein Kinase Catalytic Subunit Prevents Ferroptosis in Retinal Pigment Epithelial Cells.
Wang X, Wang X, Zhao Z, Wang Q, Zhu X, Ou Q, Xu JY, Lu L, Gao F, Wang J, Bi Y, Xu GT, Jin C, Tian H
Investigative ophthalmology & visual science 2025 Jan 2;66(1):50
Investigative ophthalmology & visual science 2025 Jan 2;66(1):50
Zinc-induced photocrosslinked konjac glucomannan/glycyrrhizic acid hydrogel promotes skin wound healing in diabetic mice through immune regulation.
Li J, Wu D, Su Z, Guo J, Cui L, Su H, Chen Y, Yu B
Carbohydrate polymers 2025 Jan 15;348(Pt A):122780
Carbohydrate polymers 2025 Jan 15;348(Pt A):122780
Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells.
Wang P, Wang Y, Zhao X, Zheng R, Zhang Y, Meng R, Dong H, Liang S, He X, Song Y, Su H, Yan B, Yang AG, Jia L
Signal transduction and targeted therapy 2025 Jan 15;10(1):20
Signal transduction and targeted therapy 2025 Jan 15;10(1):20
Mechanism of dihydroartemisinin in the treatment of ischaemia/reperfusion-induced acute kidney injury via network pharmacology, molecular dynamics simulation and experiments.
Jiang B, Liu J, Qu Z, Wang Y, Wang Y, Li Z, Jin X, Lao Y, He R, Yang S
International immunopharmacology 2025 Jan 10;144:113705
International immunopharmacology 2025 Jan 10;144:113705
CAVIN2 attenuates ventilator-induced lung injury in rats by MAPK/ERK1/2 signaling pathway.
Zhu Q, Wu K, Lv J, Yang R, Li C, Liu W, Zhang J, Lian S, Wang L, Zhang X
International immunopharmacology 2025 Jan 10;144:113669
International immunopharmacology 2025 Jan 10;144:113669
Extracellular vesicles derived from bone marrow mesenchymal stem cells ameliorate chronic liver damage via microRNA-136-5p.
Jiang X, Liu Z, You H, Tang Z, Ma Y, Nie R, Yang Z, Che N, Liu W
Molecular and cellular biochemistry 2025 Feb;480(2):951-969
Molecular and cellular biochemistry 2025 Feb;480(2):951-969
Influence of the ERK/CHGB pathway in breast cancer progression under chronic stress.
Wang Y, Hou X, Wu Z, Ren J, Zhao Y
The international journal of biochemistry & cell biology 2025 Feb;179:106733
The international journal of biochemistry & cell biology 2025 Feb;179:106733
Design and Synthesis of Novel MEK Inhibitors for the Treatment of Solid Tumors.
Zeng J, Luo Z, Zhao T, Xia C, Liu F, Li N, Qu L, Wang C
Chemical biology & drug design 2025 Feb;105(2):e70067
Chemical biology & drug design 2025 Feb;105(2):e70067
HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway.
He X, Deng B, Zhang C, Zhang G, Yang F, Zhu D, Yang Y, Ma B, Hu X, Wang Y, Kang X
Molecular medicine (Cambridge, Mass.) 2025 Feb 9;31(1):53
Molecular medicine (Cambridge, Mass.) 2025 Feb 9;31(1):53
SJB2-043, a USP1 Inhibitor, Suppresses A549 Cell Proliferation, Migration, and EMT via Modulation of PI3K/AKT/mTOR, MAPK, and Wnt Signaling Pathways.
Wu L, Yu M, Liang H, Lin L, Li H, Chen G, Muhetaer H, Li J, Wu B, Jia X, Dang Y, Zheng G, Li C
Current issues in molecular biology 2025 Feb 27;47(3)
Current issues in molecular biology 2025 Feb 27;47(3)
Melatonin-pretreated mesenchymal stem cell-derived exosomes alleviate cavernous fibrosis in a rat model of nerve injury-induced erectile dysfunction via miR-145-5p/TGF-β/Smad axis.
Zhang X, Yang M, Chen X, Zhang M, Peng Y, Lu M
Stem cell research & therapy 2025 Feb 25;16(1):96
Stem cell research & therapy 2025 Feb 25;16(1):96
Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury.
Rao Z, Tang Y, Zhu J, Lu Z, Chen Z, Wang J, Bao Y, Mukondiwa AV, Wang C, Wang X, Luo Y, Li X
Nanomaterials (Basel, Switzerland) 2025 Feb 23;15(5)
Nanomaterials (Basel, Switzerland) 2025 Feb 23;15(5)
ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway.
Wang L, Wang J, Wang N, Wang X, Song M, Zhou Y, Wang Z, Meng H, Guo E, Miao S
iScience 2025 Feb 21;28(2):111633
iScience 2025 Feb 21;28(2):111633
KRAS(G12D)-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC.
Jiang X, Wang T, Zhao B, Sun H, Dong Y, Ma Y, Li Z, Wu Y, Wang K, Guan X, Long B, Qin L, Shi W, Shi L, He Q, Liu W, Li M, Xiao L, Zhou C, Sun H, Yang J, Guan J, Zhou H, Yu Z, Jiao Z
Cell reports. Medicine 2025 Feb 18;6(2):101966
Cell reports. Medicine 2025 Feb 18;6(2):101966
S100A12 triggers NETosis to aggravate myocardial infarction injury via the Annexin A5-calcium axis.
Zhang X, Song H, Liu D, Cai Y, Liu Z, Zhang X, Zhao X, Zhang Y, Jing Q, Yan C, Han Y
Nature communications 2025 Feb 18;16(1):1746
Nature communications 2025 Feb 18;16(1):1746
Discovery of novel capsaicin analogs as TRPV1 inhibitors for the treatment of idiopathic pulmonary fibrosis.
Cao Y, Wen Y, Zhou Z, Xi R, Shuai W, Zhang J, Suksamrarn A, Zhang G, Lu XX, Wang F
European journal of medicinal chemistry 2025 Feb 15;284:117229
European journal of medicinal chemistry 2025 Feb 15;284:117229
Arthrocolin B Impairs Adipogenesis via Delaying Cell Cycle Progression During the Mitotic Clonal Expansion Period.
Cao G, Liao X, Zhao S, Li M, Xie Z, Yang J, Li Y, Zhu Z, Jin X, Huang R, Guo Z, Niu X, Ji X
International journal of molecular sciences 2025 Feb 10;26(4)
International journal of molecular sciences 2025 Feb 10;26(4)
RAB3GAP2 silencing alleviates oxidative stress in cataracts by enhancing Mfn2-mediated mitochondrial autophagy by activating JNK/STAT3.
Huang Y, Liu Q, Chen L, Tan X, Zeng D, Zhang Y, Qin J, Zeng F, Wei X, Zhong Q, Zhang J, Yuan D
International journal of biological macromolecules 2025 Dec;334(Pt 2):149102
International journal of biological macromolecules 2025 Dec;334(Pt 2):149102
Structural characterisation of a polysaccharide from Sanghuangporus vaninii and its synergistic anti-hepatocellular carcinoma activity in combination with sorafenib.
Li J, Shi M, Jia B, Liu S, Zhao Y
International journal of biological macromolecules 2025 Dec;334(Pt 1):148778
International journal of biological macromolecules 2025 Dec;334(Pt 1):148778
RhoE downregulation leads to enhanced cholesterol biosynthesis and sorafenib resistance in hepatocellular carcinoma.
Feng J, Ye L, Chen C, Zhu Y, Liu R, Yu H, Lu L, Gong K, Li W
The Journal of biological chemistry 2025 Dec;301(12):110918
The Journal of biological chemistry 2025 Dec;301(12):110918
Co-fermentation of honeysuckle-Cassia seeds by Lactobacillus acidophilus and Bacillus subtilis: A new approach to attenuate alcohol-induced acute gastric mucosal damage and modulate immune response.
Zhou M, Cao X, Ji H, Liu Z, Guo H, Zhang Y, Huang Y, Wang F, Pang M, Wei Y
Food research international (Ottawa, Ont.) 2025 Dec;222(Pt 1):117639
Food research international (Ottawa, Ont.) 2025 Dec;222(Pt 1):117639
UBE2M inhibits neoplastic cell proliferation via MKK7-JNK-EGR1 axis in melanoma.
Xu L, Pan C, Wang Y, Ni L, Zeng P, Lin X, Lyu X, Huang S, Dang N
Journal of translational medicine 2025 Dec 8;24(1):52
Journal of translational medicine 2025 Dec 8;24(1):52
Nicotine exacerbates MASH via inducing intestinal dysbiosis and barrier dysfunction.
Yi F, Wang J, Chen Y, Xia Y, Zhou H, Huang Y, Shen Y, Fang S, Wang X, Zhang Y, Chen Y, Chen D
Communications biology 2025 Dec 5;8(1):1748
Communications biology 2025 Dec 5;8(1):1748
The NAWG combinatorial strategy activates MAPK signaling to restore extracellular matrix architecture in aging skin.
Zhang M, Pan L, Ren T, Du X, Mu Y, Liu S, Bao Y, Ma L, Luo J, Li F, Zheng F, Cao S, Yue H
Medicine 2025 Dec 5;104(49):e46335
Medicine 2025 Dec 5;104(49):e46335
CYP8B1 inhibits hepatocellular carcinoma progression by repressing PAK4 transcription through inhibition of nuclear translocation of u-STAT1.
Xu L, Xiong L, Yuan J, Chen Y, Chen F, Wang S, Xu X
Cell death & disease 2025 Dec 31;17(1):172
Cell death & disease 2025 Dec 31;17(1):172
Tubuloside B alleviates con A-induced acute liver injury by inhibiting the IL-23/JAK2/STAT3 signaling pathway hyperactivation during Th17 cell differentiation.
Luo J, Yu Z, An W, Li M, Wei H, Wang Z, He L, Xiao F, Wei H
International immunopharmacology 2025 Dec 3;166:115586
International immunopharmacology 2025 Dec 3;166:115586
Liensinine can improve vascular remodeling in hypertension through the ferroptosis-related TLR4 inflammatory pathway.
Chen D, Jia P, Wang M, Du B, Du H, Huang X, Zeng J, Cai Q, Zhang L, Zhu Y, Lin S, Lian D, Peng J
Journal of molecular medicine (Berlin, Germany) 2025 Dec 26;104(1):13
Journal of molecular medicine (Berlin, Germany) 2025 Dec 26;104(1):13
Promoting astrocyte-neuron triiodothyronine shuttling attenuates brain damage in neonatal hypoxic-ischemic encephalopathy.
Yu G, Yang Y, Zhou W, Wang X, Feng Y, Wang X, Lin Z
Journal of neuroinflammation 2025 Dec 2;23(1):5
Journal of neuroinflammation 2025 Dec 2;23(1):5
Hsa_circ_0000437 promotes the progression of rheumatic valvular heart disease by activating the mitogen-activated protein kinase signaling pathways after sponging let-7f-5p and targeting RAS-like proto-oncogene B.
Zhu L, Li N, Shi H, Song J, Fang Z, Shen Q, Zhu X, Dan Y, Shao G, Sun L
Human cell 2025 Dec 15;39(1):19
Human cell 2025 Dec 15;39(1):19
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.
Zhao Y, Hu W, Wang X, Ren Z, Gong Y, Liu L, Sun Y
International journal of molecular sciences 2025 Dec 12;26(24)
International journal of molecular sciences 2025 Dec 12;26(24)
Anti-Inflammatory Effect of a Polysaccharide Derived from Artocarpus heterophyllus Lam. Pulp on Lipopolysaccharide-Stimulated RAW264.7 Macrophages Through Inhibiting MAPK/ERK Signaling Pathway.
Bai B, Liu M, Xu P, Zhang Y, Xu F, Wu G, Zhou Y, Zhu K
Nutrients 2025 Dec 12;17(24)
Nutrients 2025 Dec 12;17(24)
Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia.
Chen Y, Zhou Y, Qi Y, Miao T, Shi J, Jin D, Zhong TP
Communications biology 2025 Dec 10;9(1):33
Communications biology 2025 Dec 10;9(1):33
BMAL1 downregulation drives PANoptosis and the osteogenic differentiation impairment of PDLSCs by ERK/AP-1 signaling pathway.
Wang L, Liu T, Zhang W, Liu H, Qi Y, Li M
Journal of periodontology 2025 Aug;96(8):906-919
Journal of periodontology 2025 Aug;96(8):906-919
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
Wu D, Li M, Hong Y, Jin L, Liu Q, Sun C, Li L, Han X, Deng S, Feng Y, Shen Y, Kai G
Journal of advanced research 2025 Aug;74:621-635
Journal of advanced research 2025 Aug;74:621-635
Microneedles loaded with l-arginine-modified puerarin-derived carbon nanoparticles improved treatment of diabetic wound via photothermal and nitric oxide-based gas therapy.
Su X, Geng X, Li F, Song M, Lv R, Zhang Y, Yuan J, Dong J, Shi Y, Zhao L
Journal of colloid and interface science 2025 Aug;691:137353
Journal of colloid and interface science 2025 Aug;691:137353
Zika virus capsid protein impairs neural differentiation.
Wang Y, Ma ZH, Hassaan NA, Hao G, Wang PH, Yao M, Wu C, Chen M, Xing L
International journal of biological macromolecules 2025 Aug;319(Pt 2):145479
International journal of biological macromolecules 2025 Aug;319(Pt 2):145479
Biomimetic Nanoplatform Integrating CeO₂ Nanozymes and Anti-Inflammatory Peptides for Osteoarthritis Therapy.
Yang C, Liao X, Wang Y, Zhong W, Xian F, Gao M, Zeng M, Chen J, Chen X, Li M, Zhou K
Small (Weinheim an der Bergstrasse, Germany) 2025 Aug;21(32):e2502677
Small (Weinheim an der Bergstrasse, Germany) 2025 Aug;21(32):e2502677
The involvement of Rab5 in regulating haematopoiesis in the Chinese mitten crab Eriocheir sinensis.
Qiao X, Zhao X, Zeng Y, Gu X, Wang Y, Yu H, He M, Wang L, Song L
Fish & shellfish immunology 2025 Aug;163:110363
Fish & shellfish immunology 2025 Aug;163:110363
Biliverdin alleviates cerebral ischemia-reperfusion injury by regulating the P4hb/MAPK/mTOR pathway to inhibit autophagy.
Jiang H, Bai W, Yang Y, Zhou G, Li J, Li X, Wan X, Shao J
Cellular signalling 2025 Aug;132:111815
Cellular signalling 2025 Aug;132:111815
G-protein coupled receptor 183 (GPR183) inhibits visceral metastasis of non-small cell lung cancer.
Cheng L, Li S, Cui Z, Sun X, Gong M, Chen Y, Meng L, Liao Y
Clinical & experimental metastasis 2025 Aug 4;42(5):44
Clinical & experimental metastasis 2025 Aug 4;42(5):44
Identification of IQGAP3 prognostic potential and involvement in immune cell infiltration in LUAD.
Chen M, Zhang P, You C, Chen S
European journal of medical research 2025 Aug 4;30(1):701
European journal of medical research 2025 Aug 4;30(1):701
Promotion of the invasion and metastasis of breast cancer by B7-H3 through CCR5High tumor-associated macrophages.
Dai T, Xu Z, Li Y, Wu M, Qiu Y, Chao Z, Jiang R, Chen Y, Lu L
Cancer cell international 2025 Aug 4;25(1):293
Cancer cell international 2025 Aug 4;25(1):293
DDX18 promotes growth and metastasis of hepatocellular carcinoma via activating EMT and MAPK signaling.
Xu X, Yu X, Zhang N, Wang F, Chen Z
Journal of gastrointestinal oncology 2025 Aug 30;16(4):1622-1634
Journal of gastrointestinal oncology 2025 Aug 30;16(4):1622-1634
MED10 as a Novel Oncogenic Driver in HCC: Promoting Cell Cycle Progression and Proliferation Through RAF1 Activation.
Liu J, Lv Y, Liu K, Li Z, Chen B, Bu Y
Frontiers in bioscience (Landmark edition) 2025 Aug 29;30(8):39944
Frontiers in bioscience (Landmark edition) 2025 Aug 29;30(8):39944
Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.
Zhu S, Zhang X, Liu W, Zhou Z, Xiong S, Chen X, Peng C
Journal of experimental & clinical cancer research : CR 2025 Aug 27;44(1):255
Journal of experimental & clinical cancer research : CR 2025 Aug 27;44(1):255
VDR Decrease Enhances the Efficacy of 1,25-Dihydroxyvitamin D3 Inhibiting Gefitinib Resistance by Regulating EGFR/FASN Loop in NSCLC Cells.
Yang J, Fang M, Hou M, Duan Y, Wang J, Hu K, Liu S, Liu X, Peng X, Ding X, Jia Z
Pharmaceuticals (Basel, Switzerland) 2025 Aug 21;18(8)
Pharmaceuticals (Basel, Switzerland) 2025 Aug 21;18(8)
Baicalin Alleviates ADAM17/EGFR Axis-Induced Peritonitis in Weaned Piglets Infected by Glaesserella parasuis.
Lu Q, Liu X, Tian J, Guo P, Ye C, Fu S, Liu Y, Qiu Y
Animals : an open access journal from MDPI 2025 Aug 21;15(16)
Animals : an open access journal from MDPI 2025 Aug 21;15(16)
Single-cell transcriptome analysis identifies MIF as a novel tumor-associated neutrophil marker for pancreatic ductal adenocarcinoma.
Zeng Y, Yu J, Chen Y, Zhuang J, Liang X, Li Y, Chen S, Pang W, Zeng L
NPJ precision oncology 2025 Aug 20;9(1):293
NPJ precision oncology 2025 Aug 20;9(1):293
Membrane protein CRISPR screen identifies RPSA as an essential host factor for porcine epidemic diarrhea virus replication.
Zhao Y, Guo G, Sun Y, Zhang M, Yang G, Liu Z, Song Y, Ghonaim AH, Ma N, Zhang M, Jongkaewwattana A, He Q, Li W
Journal of virology 2025 Aug 19;99(8):e0064925
Journal of virology 2025 Aug 19;99(8):e0064925
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
Li J, Ma C, Cao P, Guo W, Wang P, Yang Y, Ding B, Yin F, Li Z, Wang Y, Li S, Huang C, Wang X, Zhou T, Chang A, Zhao L, Gao S, Zhao T, Wang H, Yu J, Xu J, Feng Y, Hao J
Cell reports. Medicine 2025 Aug 19;6(8):102292
Cell reports. Medicine 2025 Aug 19;6(8):102292
Protein arginine methyltransferase 1 stimulates basal cell proliferation and migration to maintain corneal epithelial homeostasis.
Yang J, Hu M, Yang M, Ni H, Zhou J, Li D, Ran J, Liu M
Cell death discovery 2025 Aug 15;11(1):385
Cell death discovery 2025 Aug 15;11(1):385
Chondroitin sulfate protects against synaptic impairment caused by fluorosis through the Erk1/2-MMP-9 signaling pathway.
Ai F, Wang S, Ye L, Wan W, Zhou X, Liu M, Mo K, Lu Y, Wei N, Guan Z, Liu Y
Scientific reports 2025 Aug 13;15(1):29760
Scientific reports 2025 Aug 13;15(1):29760
Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.
Li J, Wu X, Yan S, Shen J, Tong T, Aslam MS, Zeng J, Chen Y, Chen W, Li M, You Z, Gong K, Yang J, Zhu M, Meng X
Molecular neurobiology 2025 Apr;62(4):4221-4236
Molecular neurobiology 2025 Apr;62(4):4221-4236
PRMT5 Inhibition Enhances Therapeutic Efficacy of Cisplatin via Mediating miR-29b-3p-Mcl-1 Expression in Lung Adenocarcinoma.
Li H, Fan J, Shen W, Zhang Y, Zhu X, Li P, Gu Z, Jing P
Cell biology international 2025 Apr;49(4):407-418
Cell biology international 2025 Apr;49(4):407-418
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Ma YN, Jiang XM, Hu XQ, Wang L, Gao JJ, Liu H, Qi FH, Song PP, Tang W
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Mycoplasma ovipnuemoniae impairs the immune response of sheep and suppresses neutrophil function by inhibiting S100A9.
Yan C, Dong T, Shan Y, Zhao B, Yang H, Cai Y, Li S, Liu Q, Chu Y, Hao H, Cheng Z, Liu M, Zhang Y
Veterinary microbiology 2025 Apr;303:110446
Veterinary microbiology 2025 Apr;303:110446
hUC-MSCs Prevent Acute High-Altitude Injury through Apoe/Pdgf-b/p-Erk1/2 Axis in Mice.
Yan S, Bi Y, Liu Q, Song S, Ma L, Ji G
Stem cell reviews and reports 2025 Apr;21(3):834-848
Stem cell reviews and reports 2025 Apr;21(3):834-848
TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney.
Xu L, Wu X, Long L, Li S, Huang M, Li M, Feng P, Levi M, Chen W, Wang L, Li C, Wang W
Metabolism: clinical and experimental 2025 Apr;165:156133
Metabolism: clinical and experimental 2025 Apr;165:156133
Brusatol inhibits malignant phenotypes and lipid metabolism of osteosarcoma cells by regulating PI3K/AKT and MAPK pathways.
Yuan X, Yu S, Lin L, Chen Y, Wu Z, Fang X, Zhang W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156464
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156464
Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non-Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production.
Zeng QG, Li L, Chang T, Sun Y, Zheng B, Xue LN, Liu CL, Li XQ, Huang RT, Gu JX, An ZR, Yao HT, Zhou DY, Fan J, Dai Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411503
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411503
Berberine Alleviates 1-Methyl-3-Nitro-1-Nitrosoguanidine- Induced Chronic Atrophic Gastritis in Rats.
Wang L, Xie L
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2025 Apr 7;36(11):723-731
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2025 Apr 7;36(11):723-731
Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling.
Han X, He G, Wang J, Lou H, Chen L, Zhang L, Liu B, Wu D, Liu X, Wang S, Zhang C, Guo L
Metabolic brain disease 2025 Apr 4;40(4):170
Metabolic brain disease 2025 Apr 4;40(4):170
Alleviation of obesity cardiomyopathy by Fisetin through the inhibition of NF-κB/MAPK signaling.
Liu X, Zhu J, Li C, Tong C, Zhao C, Lin X, Wang Y, Alinejad T, Wu H, Chen G, Li L
International immunopharmacology 2025 Apr 4;151:114319
International immunopharmacology 2025 Apr 4;151:114319
Gαq/11 Signaling Modulates Fibroblast Growth Factor 23 Production and Contributes to Acute Kidney Injury.
Jiang J, Zhang Y, Zuo Y, Bai Y, He Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 30;39(8):e70544
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 30;39(8):e70544
Luteolin 7-Glucuronide in Artemisia rupestris L. Extract Attenuates Pulmonary Fibrosis by Inhibiting Fibroblast Activation and FMT via Targeting of TGF-β1.
Peng L, Fan Y, Wang L, Han C, Hao Z
Antioxidants (Basel, Switzerland) 2025 Apr 29;14(5)
Antioxidants (Basel, Switzerland) 2025 Apr 29;14(5)
Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes.
Shi L, Wang M, Yu R, An Y, Wang X, Zhang Y, Shi Y, Han C, Liu J
Behavioural brain research 2025 Apr 27;484:115493
Behavioural brain research 2025 Apr 27;484:115493
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Ma Z, Hu N, Zheng L, Xue Y, Zhou C, Wang W, Cheng X, Luo T, Yu J, Hu L
Journal of ovarian research 2025 Apr 26;18(1):85
Journal of ovarian research 2025 Apr 26;18(1):85
Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis.
Wu C, Long L, Wang M, Shen L, Hu J, Tang H, Feng S, Liu X, Shi Y, Tang S, Chen Y
Communications biology 2025 Apr 24;8(1):658
Communications biology 2025 Apr 24;8(1):658
Impact of Escherichia coli and Lipopolysaccharide on the MAPK Signaling Pathway, MMPs, TIMPs, and the uPA System in Bovine Mammary Epithelial Cells.
Zhang Y, Ding Y, Liang J, Zhang K, Su H, Wang D, Zhang M, Zhao F, Sun Z, Wu Z, Wang F, Cao G, Zhang Y
International journal of molecular sciences 2025 Apr 20;26(8)
International journal of molecular sciences 2025 Apr 20;26(8)
Cytotoxicity and inhibitory potential of CUDC-101 in non-small cell lung cancer cells with rare EGFR L861Q mutation.
Chu C, Xu H, Liu C, Wei X, Li L, Wang R, Cui W, Zhang G, Liu C, Wang K, An L, He F
Current research in toxicology 2024;7:100194
Current research in toxicology 2024;7:100194
Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling.
Wang Y, Zhang X, Hung I, Liu C, Ren W, Ge L, Wang H
Research (Washington, D.C.) 2024;7:0418
Research (Washington, D.C.) 2024;7:0418
Qingfei Formula Protects against Human Respiratory Syn cytial Virus-induced Lung Inflammatory Injury by Regulating the M APK Signaling Pathway.
Sun YL, Zhao PP, Zhu CB, Li XM, Yuan B
Combinatorial chemistry & high throughput screening 2024;27(7):969-983
Combinatorial chemistry & high throughput screening 2024;27(7):969-983
Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.
Shao L, Wang N, Yan Y, Tan Y, Wu Q, Lei L, Wang M, Liu L
Iranian journal of basic medical sciences 2024;27(6):685-694
Iranian journal of basic medical sciences 2024;27(6):685-694
miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK.
Dai Q, Shi R, Zhang G, Wang Y, Ye L, Peng L, Guo S, He J, Yang H, Jiang Y
Experimental biology and medicine (Maywood, N.J.) 2024;249:10111
Experimental biology and medicine (Maywood, N.J.) 2024;249:10111
Transient Receptor Potential Ankyrin 1 (TRPA1) Mediated LPS-Induced Inflammation in Periodontal Ligament Stem Cells by Inhibiting the Phosphorylation of JNK.
Wang X, Chen X, Gao J, Jin Z
Stem cells international 2024;2024:7461604
Stem cells international 2024;2024:7461604
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
Hu Y, Li Y, Xiong H, Zhang Y, Wang F, Zhuo W, Zeng Z, Zhao Y, Wang H, Hu P, Han S, Huang Y, Lv G, Zhao G
International journal of biological sciences 2024;20(11):4341-4363
International journal of biological sciences 2024;20(11):4341-4363
Dual role of CD73 as a signaling molecule and adenosine-generating enzyme in colorectal cancer progression and immune evasion.
Lian W, Jiang D, Lin W, Jiang M, Zhang Y, Wang H, Zhao L
International journal of biological sciences 2024;20(1):137-151
International journal of biological sciences 2024;20(1):137-151
Ferroptosis-related gene MAPK3 is associated with the neurological outcome after cardiac arrest.
Hou HX, Pang L, Zhao L, Xing J
PloS one 2024;19(6):e0301647
PloS one 2024;19(6):e0301647
FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.
Zhao M, Rong R, Zhang C, Yang H, Han X, Fan Z, Zheng Y, Zhang J
Current stem cell research & therapy 2024;19(3):417-425
Current stem cell research & therapy 2024;19(3):417-425
Naodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway.
Yang YY, Deng RR, Xiang DX
Drug design, development and therapy 2024;18:1499-1514
Drug design, development and therapy 2024;18:1499-1514
Fusobacterium Nucleatum Aggravates Intestinal Barrier Impairment and Colitis Through IL-8 Induced Neutrophil Chemotaxis by Activating Epithelial Cells.
Wang Z, Li B, Bao L, Chen Y, Yang J, Xu F, Shi S, Chen W, Wang B, Liu Y
Journal of inflammation research 2024;17:8407-8420
Journal of inflammation research 2024;17:8407-8420
Cistanche deserticola polysaccharide alleviates constipation by regulating intestinal barrier function and intestinal microbiota and their metabolites.
Yu Z, Zhang Z, Hu C, Xie L, Zhang R, Gao R, Zhang Z, Wei X, Li T, Guo J
American journal of translational research 2024;16(11):7036-7053
American journal of translational research 2024;16(11):7036-7053
Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway.
Zhou Y, Lv J, Jin S, Fu C, Liu B, Shen Y, Li M, Zhang Y, Feng N
Frontiers in pharmacology 2024;15:1526051
Frontiers in pharmacology 2024;15:1526051
Inhibition of Sat1 alleviates myocardial ischemia-reperfusion injury through regulation of ferroptosis via MAPK/ERK pathway.
Liu Z, Chen H, Song Y, Chen K, Pan S, Yang S, Lu D
Frontiers in pharmacology 2024;15:1476718
Frontiers in pharmacology 2024;15:1476718
Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment.
Ebott J, McAdams J, Kim C, Jansen C, Woodman M, De La Cruz P, Schrol C, Ribeiro J, James N
Frontiers in pharmacology 2024;15:1375421
Frontiers in pharmacology 2024;15:1375421
γ-Synuclein promotes proliferation and inhibits apoptosis of oral squamous cell carcinoma via JAK2/STAT5b signaling pathway.
Yang J, Ren Z, Wang F, Zheng J, Zhuang Z, Zeng Y
American journal of cancer research 2024;14(5):2408-2423
American journal of cancer research 2024;14(5):2408-2423
Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling.
Liu J, Wang S, Zhang C, Wei Z, Han D, Song Y, Song X, Chao F, Wu Z, Xu G, Chen G
American journal of cancer research 2024;14(2):490-506
American journal of cancer research 2024;14(2):490-506
Endogenous hydrogen sulfide accelerated trauma-induced heterotopic ossification through the Ca(2+)/ERK pathway-enhanced aberrant osteogenic activity.
Yuan Z, Li J, He K, Sun Z, Luo G, Liu H, Dong J, Zhou C, Cui H, Fan C
Redox biology 2024 Sep;75:103265
Redox biology 2024 Sep;75:103265
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
Gu J, Jin J, Ren X, Zhang X, Li J, Wang X, Zhang S, Yin X, Zhang Q, Wang Z
Diabetes & metabolism journal 2024 Sep;48(5):885-900
Diabetes & metabolism journal 2024 Sep;48(5):885-900
The effects and mechanisms of AM1241 in alleviating cerebral ischemia-reperfusion injury.
Li S, Yang P, Wu Z, Huang W, Zhu X, Zhong L
Brain research bulletin 2024 Sep;215:111025
Brain research bulletin 2024 Sep;215:111025
Melatonin reverses EGFR-TKI therapeutic resistance by modulating crosstalk between circadian-related gene signature and immune infiltration patterns in patients with COVID-19 and lung adenocarcinoma.
Dai Z, Lin B, Cao Y, Wang L, Liao K, Guo L, Zhang J
Computers in biology and medicine 2024 Sep;180:108937
Computers in biology and medicine 2024 Sep;180:108937
Theabrownin from Pu-erh Tea Improves DSS-Induced Colitis via Restoring Gut Homeostasis and Inhibiting TLR2&4 Signaling Pathway.
Zhao L, Zhao C, Miao Y, Lei S, Li Y, Gong J, Peng C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155852
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155852
Canthin-6-one analogs block Newcastle disease virus proliferation via suppressing the Akt and ERK pathways.
Wang C, Wang T, Dai J, Han Y, Hu R, Li N, Yang Z, Wang J
Poultry science 2024 Sep;103(9):103944
Poultry science 2024 Sep;103(9):103944
Tumoral EIF4EBP1 regulates the crosstalk between tumor-associated macrophages and tumor cells in MRTK.
Wu X, Mi T, Jin L, Ren C, Wang J, Zhang Z, Liu J, Wang Z, Guo P, He D
European journal of pharmacology 2024 Sep 5;978:176787
European journal of pharmacology 2024 Sep 5;978:176787
Bioinspired Collagen Scaffold Loaded with bFGF-Overexpressing Human Mesenchymal Stromal Cells Accelerating Diabetic Skin Wound Healing via HIF-1 Signal Pathway Regulated Neovascularization.
Huang F, Gao T, Feng Y, Xie Y, Tai C, Huang Y, Ling L, Wang B
ACS applied materials & interfaces 2024 Sep 4;16(35):45989-46004
ACS applied materials & interfaces 2024 Sep 4;16(35):45989-46004
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Geng N, Fan M, Kuang B, Zhang F, Xian M, Deng L, Chen C, Pan Y, Chen J, Feng N, Liang L, Ye Y, Liu K, Li X, Du Y, Guo F
Nature communications 2024 Sep 4;15(1):7712
Nature communications 2024 Sep 4;15(1):7712
Spinster homolog 2/S1P signaling ameliorates macrophage inflammatory response to bacterial infections by balancing PGE(2) production.
Fang C, Ren P, He Y, Wang Y, Yao S, Zhao C, Li X, Zhang X, Li J, Li M
Cell communication and signaling : CCS 2024 Sep 30;22(1):463
Cell communication and signaling : CCS 2024 Sep 30;22(1):463
Neohesperidin Attenuates DSS-Induced Ulcerative Colitis by Inhibiting Inflammation, Reducing Intestinal Barrier Damage, and Modulating Intestinal Flora Composition.
Ju T, Song Z, Qin D, Cheng J, Li T, Hu G, Fu S
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20419-20431
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20419-20431
Omics-based pharmacological evaluation reveals Yuanhu Zhitong oral liquid ameliorates arthritis by regulating PKC/ERK/NF-κB signaling pathway.
Zhang K, Yin Z, Chen F, Cao Z, Guan J, Chen C, Wang Y, Fan G
Journal of ethnopharmacology 2024 Sep 15;331:118289
Journal of ethnopharmacology 2024 Sep 15;331:118289
CREB1 promotes cholangiocarcinoma metastasis through transcriptional regulation of the LAYN-mediated TLN1/β1 integrin axis: CREB1 promotes cholangiocarcinoma metastasis through regulating LAYN/TLN1/β1 integrin axis.
Liang S, Zhou S, Tang Y, Xiao M, Ye K
Heliyon 2024 Sep 15;10(17):e36595
Heliyon 2024 Sep 15;10(17):e36595
ACYP2 functions as an innovative nano-therapeutic target to impede the progression of hepatocellular carcinoma by inhibiting the activity of TERT and the KCNN4/ERK pathway.
Wu Y, Bao H, Wu J, Chen B, Xu J, Jin K, Chen L, Zhu G, Wang F
Journal of nanobiotechnology 2024 Sep 12;22(1):557
Journal of nanobiotechnology 2024 Sep 12;22(1):557
Design, synthesis, and biological evaluation of naphthalene imidazo[1,2-b]pyridazine hybrid derivatives as VEGFR selective inhibitors.
Wang S, Gan L, Han L, Deng P, Li Y, He D, Chi H, Zhu L, Li Y, Long R, Gan Z
Archiv der Pharmazie 2024 Oct;357(10):e2400411
Archiv der Pharmazie 2024 Oct;357(10):e2400411
Single-cell and spatial transcriptomics reveal apelin/APJ pathway's role in microvessel formation and tumour progression in hepatocellular carcinoma.
Zhu Y, Zhang P, Huo X, Ling Y, Lv X, Lin S, Song H
Journal of cellular and molecular medicine 2024 Oct;28(20):e70152
Journal of cellular and molecular medicine 2024 Oct;28(20):e70152
Structure characterization and immunological activity of capsular polysaccharide from live and heat-killed Lacticaseibacillus paracasei 6235.
Wang Y, Liu R, Xie Z, Du L, Wang Y, Han J, Zhang L
International journal of biological macromolecules 2024 Oct;277(Pt 1):134010
International journal of biological macromolecules 2024 Oct;277(Pt 1):134010
EREG silencing inhibits tumorigenesis via inactivating ERK/p38 MAPK pathway in pancreatic ductal adenocarcinoma.
Liu F, Wu W, Cao W, Feng L, Yuan J, Ren Z, Dai N, Wang X, Li X, Yue S
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167336
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167336
MAPK signaling pathway participates in the regulation of intestinal phosphorus and calcium absorption in broiler chickens via 1,25-dihydroxyvitamin D(3).
Han J, Lv X, He L, Liu M, Qu H, Xi L, Zhang L, Ma B, Shi C, Yang G, Wang Z
Poultry science 2024 Oct;103(10):104052
Poultry science 2024 Oct;103(10):104052
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Gao X, Fu S, Wen J, Yan A, Yang S, Zhang Y, Liu D, He D
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Aldo-keto reductase family 1 member C3 mediates radioresistance of esophageal cancer cells through suppressing MAPK and AKT signaling.
Xiong W, Xie Y, Wang D, Huang X, Hao X, Liu J, Liu X, Gu X, Sun S, Li Y, Li J
BMC cancer 2024 Oct 7;24(1):1236
BMC cancer 2024 Oct 7;24(1):1236
Inhibition of neutrophil swarming by type I interferon promotes intracellular bacterial evasion.
Li S, Yao Q, Li J, Yang H, Qian R, Zheng M, Wu N, Jiang H, Li L, Zeng Z
Nature communications 2024 Oct 7;15(1):8663
Nature communications 2024 Oct 7;15(1):8663
The protective mechanism of Tao Hong Si Wu decoction against breast cancer through regulation of EGFR/ERK1/2 signaling.
Huang S, Yao D, Shan C, Du X, Pan L, Wang N, Wang Y, Duan X, Peng D
Journal of ethnopharmacology 2024 Oct 5;332:118339
Journal of ethnopharmacology 2024 Oct 5;332:118339
Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4.
Meng X, Wang Z, Yang Q, Liu Y, Gao Y, Chen H, Li A, Li R, Wang J, Sun G
Cell death & disease 2024 Oct 5;15(10):729
Cell death & disease 2024 Oct 5;15(10):729
Exploring the Effect of Fidgetin-Like 1 on Colorectal Cancer Through Tissue Chip and In Vitro Experiments.
Xu Y, Shen Y, Zhang C, Zheng L, Ji F, Chen J, Cheng S, Zheng Y
Balkan medical journal 2024 Oct 31;41(6):491-498
Balkan medical journal 2024 Oct 31;41(6):491-498
CD74(+) fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloids.
Zhang J, Li S, Kuang C, Shen Y, Yu H, Chen F, Tang R, Mao S, Lv L, Qi M, Zhang J, Yuan K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70103
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70103
Lactobacillus paracasei subsp. paracasei NTU 101 prevents obesity by regulating AMPK pathways and gut microbiota in obese rat.
Kim S, Na GH, Yim DJ, Liu CF, Lin TH, Shih TW, Pan TM, Lee CL, Koo YK
Biochemical and biophysical research communications 2024 Oct 30;731:150279
Biochemical and biophysical research communications 2024 Oct 30;731:150279
Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion.
Yang L, Lin Z, Mu R, Wu W, Zhi H, Liu X, Yang H, Liu L
eLife 2024 Oct 30;13
eLife 2024 Oct 30;13
Co-Mn Complex Oxide Nanoparticles as Potential Reactive Oxygen Species Scavenging Agents for Pulmonary Fibrosis Treatment.
Yang W, Yuan H, Sun H, Hu T, Xu Y, Qiu Y, Li Y
Molecules (Basel, Switzerland) 2024 Oct 29;29(21)
Molecules (Basel, Switzerland) 2024 Oct 29;29(21)
Phytochemical determination and mechanistic investigation of Polygala tenuifolia root (Yuanzhi) extract for bronchitis: UPLC-MS/MS analysis, network pharmacology and in vitro/in vivo evaluation.
Chen T, Zhou X, Zhu M, Chen X, Chang D, Lin Y, Xu W, Zheng Y, Li S, Song J, Huang M
Journal of ethnopharmacology 2024 Oct 28;333:118418
Journal of ethnopharmacology 2024 Oct 28;333:118418
Exploring the anti-inflammatory and immune regulatory effects of Taohe Chengqi decoction in sepsis-induced lung injury.
Deng M, Chen S, Wu J, Su L, Xu Z, Jiang C, Sheng L, Yang X, Zeng L, Wang J, Dai W
Journal of ethnopharmacology 2024 Oct 28;333:118404
Journal of ethnopharmacology 2024 Oct 28;333:118404
Colon Cancer-Derived Exosomal LncRNA-XIST Promotes M2-like Macrophage Polarization by Regulating PDGFRA.
Gao B, Wang L, Wen T, Xie X, Rui X, Chen Q
International journal of molecular sciences 2024 Oct 24;25(21)
International journal of molecular sciences 2024 Oct 24;25(21)
A novel role for WZ3146 in the inhibition of cell proliferation via ERK and AKT pathway in the rare EGFR G719X mutant cells.
Li L, Liu C, Wang R, Yang X, Wei X, Chu C, Zhang G, Liu C, Cui W, Xu H, Wang K, An L, Li X
Scientific reports 2024 Oct 2;14(1):22895
Scientific reports 2024 Oct 2;14(1):22895
CircCOCH plays a critical role in Hepatocellular carcinoma through modulating miR-450a and activating PI3K/mTOR pathway.
Jiang W, Wang Y, He W, Wang P, Meng P, Zhang S
Translational oncology 2024 Nov;49:102090
Translational oncology 2024 Nov;49:102090
Luteolin detoxifies DEHP and prevents liver injury by degrading Uroc1 protein in mice.
Wang H, Zhao Z, Song M, Zhang W, Liu C, Chen S
EMBO molecular medicine 2024 Nov;16(11):2699-2724
EMBO molecular medicine 2024 Nov;16(11):2699-2724
Nuclear receptor 4A1 (NR4A1) upregulated by n-butylidenephthalide via the mitogen-activated protein kinase (MAPK) pathway ameliorates drug-induced gingival enlargement.
Ueda T, Matsuda S, Ninomiya Y, Nakashima F, Yasuda K, Furutama D, Memida T, Yoshimoto T, Kajiya M, Ohta K, Ouhara K, Mizuno N
BioFactors (Oxford, England) 2024 Nov-Dec;50(6):1192-1207
BioFactors (Oxford, England) 2024 Nov-Dec;50(6):1192-1207
Enhancing DOX efficacy against NSCLC through UDCA-mediated modulation of the TGF-β/MAPK autophagy pathways.
Li Y, Zhao H, Shen Z, Zheng Y, Jiang Y, Song Y, Cai Y
Scientific reports 2024 Nov 8;14(1):27169
Scientific reports 2024 Nov 8;14(1):27169
Novel EGFR inhibitors against resistant L858R/T790M/C797S mutant for intervention of non-small cell lung cancer.
Wang X, Qin Z, Qiu W, Xu K, Bai Y, Zeng B, Ma Y, Yang S, Shi Y, Fan Y
European journal of medicinal chemistry 2024 Nov 5;277:116711
European journal of medicinal chemistry 2024 Nov 5;277:116711
Dayuan Yin alleviates symptoms of HCoV-229E-induced pneumonia and modulates the Ras/Raf1/MEK/ERK pathway.
Li R, Zhang W, Huang B, Sun G, Xie Y, Song J, Wang S, Du G
Natural products and bioprospecting 2024 Nov 4;14(1):58
Natural products and bioprospecting 2024 Nov 4;14(1):58
Low-Medium Polarity Ginsenosides from Wild Ginseng Improves Immunity by Activating the AhR/MAPK Pathway through Tryptophan Metabolism Driven by Gut Microbiota.
Zhang M, Ma L, Luo J, Ren T, Liu S, Pan L, Bao Y, Li F, Dai Y, Pi Z, Yue H, Zheng F
Journal of agricultural and food chemistry 2024 Nov 27;72(47):26142-26154
Journal of agricultural and food chemistry 2024 Nov 27;72(47):26142-26154
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Huang W, Jiang M, Wang X, Pan D, Chen W, Fan L
Journal of agricultural and food chemistry 2024 Nov 20;72(46):25601-25619
Journal of agricultural and food chemistry 2024 Nov 20;72(46):25601-25619
Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain-induced cognitive impairment via microglial DUSP6 pathway in rats.
Xu L, Zhu A, Xu S, Zhao J, Song S, Zhu H, Huang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70152
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70152
Novel analgesic peptide derived from Cinobufacini injection suppressing inflammation and pain via ERK1/2/COX-2 pathway.
Guo L, Zhang S, Zhang C, Ren S, Zhou Z, Wang F, Wang Y, Chen Q, Wang Y, Lee WH, Zhu K, Qin D, Gao Y, Sun T
International immunopharmacology 2024 Nov 15;141:112918
International immunopharmacology 2024 Nov 15;141:112918
One-Step Gas Foaming Strategy for Constructing Strontium Nanoparticle Decorated 3D Scaffolds: a New Platform for Repairing Critical Bone Defects.
Chen Y, Li Y, Wang X, Mo X, Chen Y, Deng Z, Ye X, Yu J
ACS applied materials & interfaces 2024 Nov 13;16(45):61664-61678
ACS applied materials & interfaces 2024 Nov 13;16(45):61664-61678
7-hydroxycoumarin ameliorates ulcerative colitis in mice by inhibiting the MAPK pathway and alleviating gut microbiota dysbiosis.
Liu M, Sun H, Fu H, Fu L, Zheng X, Chen Y
BMC gastroenterology 2024 Nov 12;24(1):405
BMC gastroenterology 2024 Nov 12;24(1):405
Fentanyl induces analgesic effect through miR-381-3p/TRPM7 when combined with bupivacaine in subarachnoid injection.
Chen J, Li Y, Wang F, Gu Y, Zhou X, Liu W, Liu X, Wang Y, Ye Q
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Nov 1;202:106888
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Nov 1;202:106888
iPSC-derived NK cells with site-specific integration of CAR19 and IL24 at the multi-copy rDNA locus enhanced antitumor activity and proliferation.
Zhang Y, Shi Q, Wang P, Huang C, Tang S, Zhou M, Hu Q, Wu L, Liang D
MedComm 2024 May;5(5):e553
MedComm 2024 May;5(5):e553
Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome.
Guo X, Cao Y, He Q, Chen L, Wang Q, Zhang J, Lv W, Zhang B, Zhou X
Human cell 2024 May;37(3):689-703
Human cell 2024 May;37(3):689-703
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.
Ren D, Li W, Zeng R, Liu X, Liang H, Xiong W, Yang C, Jin X
Cell death and differentiation 2024 May;31(5):592-604
Cell death and differentiation 2024 May;31(5):592-604
Paeonol interferes with lupus nephritis by regulating M1/M2 polarization of macrophages.
Niu Y, Jin Y, Hao Y, Liang W, Tang F, Qin Z, Liang T, Shi L
Molecular immunology 2024 May;169:66-77
Molecular immunology 2024 May;169:66-77
D-alanine suppressed osteoclastogenesis derived from bone marrow macrophages and downregulated ERK/p38 signalling pathways.
Chang X, Deng J, Zhou F, Geng Z, Li X, Wang S
Archives of oral biology 2024 May;161:105912
Archives of oral biology 2024 May;161:105912
Systemic loss of CD36 aggravates NAFLD-related HCC through MEK1/2-ERK1/2 signaling pathway.
Zheng E, Chen Q, Xiao A, Luo X, Lu Q, Tian C, Liu H, Zhao J, Wei L, Yang P, Chen Y
Biochemical and biophysical research communications 2024 May 7;707:149781
Biochemical and biophysical research communications 2024 May 7;707:149781
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.
Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, Li YT, Wang TC, Kan TY, Wang J, Tao HR
Military Medical Research 2024 May 6;11(1):28
Military Medical Research 2024 May 6;11(1):28
Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis.
Lu C, Deng S, Liu Y, Yang S, Qin D, Zhang L, Wang RR, Zhang Y
International immunopharmacology 2024 May 30;133:112038
International immunopharmacology 2024 May 30;133:112038
Patient tissue-derived FGFR4-variant and wild-type colorectal cancer organoid development and anticancer drug sensitivity testing.
Lin H, Fu H, Sun S, Yin H, Yuan J, Liao J
Heliyon 2024 May 30;10(10):e30985
Heliyon 2024 May 30;10(10):e30985
BDTX-189, a novel tyrosine kinase inhibitor, inhibits cell activity via ERK and AKT pathways in the EGFR C797S triple mutant cells.
Wang R, Cui W, Li L, Wei X, Chu C, Zhang G, Liu C, Xu H, Liu C, Wang K, Li Y, An L
Chemico-biological interactions 2024 May 25;395:111033
Chemico-biological interactions 2024 May 25;395:111033
Oral Administration of Deer Bone Collagen Peptide Can Enhance the Skin Hydration Ability and Antioxidant Ability of Aging Mice Induced by D-Gal, and Regulate the Synthesis and Degradation of Collagen.
Zhang K, Zhao C, Liu K, Feng R, Zhao Y, Zong Y, Du R
Nutrients 2024 May 21;16(11)
Nutrients 2024 May 21;16(11)
CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma.
Simbulan-Rosenthal CM, Islam N, Haribabu Y, Alobaidi R, Shalamzari A, Graham G, Kuo LW, Sykora P, Rosenthal DS
Cells 2024 May 2;13(9)
Cells 2024 May 2;13(9)
Naringin attenuates Actinobacillus pleuropneumoniae-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway.
Huang QL, Huang LN, Zhao GY, Liu C, Pan XY, Li ZR, Jing XH, Qiu ZY, Xin RH
BMC veterinary research 2024 May 17;20(1):204
BMC veterinary research 2024 May 17;20(1):204
GPS2 ameliorates cigarette smoking-induced pulmonary vascular remodeling by modulating the ras-Raf-ERK axis.
Hu T, Mu C, Li Y, Hao W, Yu X, Wang Y, Han W, Li Q
Respiratory research 2024 May 16;25(1):210
Respiratory research 2024 May 16;25(1):210
Classical prescription Floris Sophorae Powder treat colorectal cancer by regulating KRAS/MEK-ERK signaling pathway.
Han LY, Yu H, Wang S, Bao YR, Li TJ, Zheng Y, Luo X, Jia MN, Zhang Q, Meng XS
Journal of ethnopharmacology 2024 May 10;325:117805
Journal of ethnopharmacology 2024 May 10;325:117805
Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota-Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice.
Zhong Z, Zhang Y, Wei Y, Li X, Ren L, Li Y, Zhang X, Chen C, Yin X, Liu R, Wang Q
Journal of agricultural and food chemistry 2024 May 1;72(17):9755-9767
Journal of agricultural and food chemistry 2024 May 1;72(17):9755-9767
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645
Experimental & molecular medicine 2024 Mar;56(3):630-645
Crocin Inhibits Orbital Fibroblasts Fibrosis in Thyroid-Associated Ophthalmopathy.
Xu S, Mao H
Current eye research 2024 Mar;49(3):330-337
Current eye research 2024 Mar;49(3):330-337
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Miao J, Tu Y, Jiang J, Ren R, Wu Q, Liang H, Wang T, Lin B, Wu J, Pan Y, Wang X, Jin H
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
Mucous cell histopathology and label-free quantitative proteomic analysis of skin mucus in fat greenling (Hexagrammos otakii) infected with Vibrio harveyi.
Wei X, Shi Y, Wang S, Liu H, Zhang Z, Yu L, Hua W, Cui D, Chen Y, Li X, Wang W
Fish & shellfish immunology 2024 Mar;146:109398
Fish & shellfish immunology 2024 Mar;146:109398
Therapeutic potential of SHCBP1 inhibitor AZD5582 in pancreatic cancer treatment.
Ma Z, Gu Q, Dai Y, Wang Q, Shi W, Jiao Z
Cancer science 2024 Mar;115(3):820-835
Cancer science 2024 Mar;115(3):820-835
Caffeic acid-grafted chitooligosaccharides downregulate MAPK and NF-kB in RAW264.7 cells.
Bui VH, Vo HN, Kim SK, Ngo DN
Chemical biology & drug design 2024 Mar;103(3):e14496
Chemical biology & drug design 2024 Mar;103(3):e14496
Antibacterial, ROS scavenging and angiogenesis promotingϵ-Polylysine/gelatin based hydrogel containing CTLP to regulate macrophages for pressure ulcer healing.
Lin P, Tang X, Zhong J, Tang F, Liu H, Peng L, Wan B, Wang M, Ye Y, Guo R, Liu X, Deng L
Biofabrication 2024 Mar 7;16(2)
Biofabrication 2024 Mar 7;16(2)
CETSA-MS-based target profiling of anti-aging natural compound quercetin.
Bai L, Deng Z, Xu M, Zhang Z, Guo G, Xue X, Wang S, Yang J, Xia Z
European journal of medicinal chemistry 2024 Mar 5;267:116203
European journal of medicinal chemistry 2024 Mar 5;267:116203
Protective Effects of Carbonated Chitosan Montmorillonite on Vomitoxin-Induced Intestinal Inflammation.
Tang R, Ju X, Niu X, Liu X, Li Y, Yu Z, Ma X, Gao Y, Li Y, Xie H, Zhou Q, Yong Y
Polymers 2024 Mar 5;16(5)
Polymers 2024 Mar 5;16(5)
Soybean-derived antihypertensive hydrolysates attenuate Ang II-induced renal damage by modulating MAPK and NF-κB signaling pathways.
Song T, Ding YY, Zhang T, Cai Q, Hu Y, Gu Q, Gu Z
Food & function 2024 Mar 4;15(5):2485-2496
Food & function 2024 Mar 4;15(5):2485-2496
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.
Liu ZD, Shi YH, Xu QC, Zhao GY, Zhu YQ, Li FX, Ma MJ, Ye JY, Huang XT, Wang XY, Xu X, Wang JQ, Zhao W, Yin XY
Cancer letters 2024 Mar 31;585:216640
Cancer letters 2024 Mar 31;585:216640
N6-methyladenosine-modified CircPSMA7 enhances bladder cancer malignancy through the miR-128-3p/MAPK1 axis.
Yi J, Ma X, Ying Y, Liu Z, Tang Y, Shu X, Sun J, Wu Y, Lu D, Wang X, Luo J, Liu B, Zheng X, Lin Y, Li J, Xie L
Cancer letters 2024 Mar 31;585:216613
Cancer letters 2024 Mar 31;585:216613
Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis.
Zhou L, Chen S, Wei Y, Sun Y, Yang Y, Lin B, Li Y, Wang C
European journal of pharmacology 2024 Mar 15;967:176365
European journal of pharmacology 2024 Mar 15;967:176365
Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice.
Zhou Y, Du Z, Wu Q, Guo M, Chen Z, Sun C, Li X, Zou Y, Zheng Z, Chen P, Cho WJ, Cho YC, Chattipakorn N, Wang Y, Liang G, Tang Q
European journal of medicinal chemistry 2024 Mar 15;268:116252
European journal of medicinal chemistry 2024 Mar 15;268:116252
Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.
Ren LK, Lu RS, Fei XB, Chen SJ, Liu P, Zhu CH, Wang X, Pan YZ
Journal of cancer research and clinical oncology 2024 Mar 14;150(3):127
Journal of cancer research and clinical oncology 2024 Mar 14;150(3):127
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
Dong P, Zhou L, Wang X, Xue L, Du Y, Cui R
European journal of medical research 2024 Mar 1;29(1):149
European journal of medical research 2024 Mar 1;29(1):149
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.
Ci M, Zhao G, Li C, Liu R, Hu X, Pan J, Shen Y, Zhang G, Li Y, Zhang L, Liang P, Cui H
Cell death & disease 2024 Mar 1;15(3):179
Cell death & disease 2024 Mar 1;15(3):179
Downregulation of HIGD1B induces mitochondria-mediated apoptosis in gastric cancer cells by inactivating Akt and ERK pathways.
Chen X, Sun B, Li S
Drug development research 2024 Jun;85(4):e22221
Drug development research 2024 Jun;85(4):e22221
Gallic Acid Attenuates Sepsis-Induced Liver Injury through C/EBPβ-Dependent MAPK Signaling Pathway.
Cai Y, Zhao D, Pan Y, Chen B, Cao Y, Han S, Lian F, Zhang Y, Yan X
Molecular nutrition & food research 2024 Jun;68(11):e2400123
Molecular nutrition & food research 2024 Jun;68(11):e2400123
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest.
Ding SM, Shi LG, Cao ZP, Zhu NN, Liu YY, Wang MY, Cui SS, Cheng HR, Liang D, Cao YX, Liu YJ
Heliyon 2024 Jun 30;10(12):e33132
Heliyon 2024 Jun 30;10(12):e33132
Deciphering the antidepressant effects of Rosa damascena essential oil mediated through the serotonergic synapse signaling pathway.
Xia N, Wang J, Guo Q, Duan J, Wang X, Zhou P, Li J, Tang T, Li T, Li H, Wu Z, Yang M, Sun J, Guo D, Chang X, Zhang X
Journal of ethnopharmacology 2024 Jun 28;328:118007
Journal of ethnopharmacology 2024 Jun 28;328:118007
A specific super-enhancer actuated by berberine regulates EGFR-mediated RAS-RAF1-MEK1/2-ERK1/2 pathway to induce nasopharyngeal carcinoma autophagy.
Wu Y, Jia Q, Tang Q, Chen L, Deng H, He Y, Tang F
Cellular & molecular biology letters 2024 Jun 28;29(1):92
Cellular & molecular biology letters 2024 Jun 28;29(1):92
Tris (2-chloroisopropyl) phosphate and Tris (nonylphenyl) phosphite Promote Human Renal Cell Apoptosis through the ERK/CEPBA/Long Non-Coding RNA Cytoskeleton Regulator Axis.
Zhao H, Yan Y, Gao Y, Wang J, Li S
Toxics 2024 Jun 22;12(7)
Toxics 2024 Jun 22;12(7)
Intracellular magnetic hyperthermia reverses sorafenib resistance in hepatocellular carcinoma through its action on signaling pathways.
Li H, Ye Z, Wang X, Yuan J, Guo J, Liu C, Yan B, Fan H, Lyu Y, Liu X
iScience 2024 Jun 21;27(6):110029
iScience 2024 Jun 21;27(6):110029
Chondroitin sulfate/silk fibroin hydrogel incorporating graphene oxide quantum dots with photothermal-effect promotes type H vessel-related wound healing.
Deng T, Lu W, Zhao X, Wang H, Zheng Y, Zheng A, Shen Z
Carbohydrate polymers 2024 Jun 15;334:121972
Carbohydrate polymers 2024 Jun 15;334:121972
d-mannose targets PD-1 to lysosomal degradation and enhances T cell-mediated anti-tumor immunity.
Dong W, Lin M, Zhang R, Sun X, Li H, Liu T, Xu Y, Lv L
Cancer letters 2024 Jun 1;591:216883
Cancer letters 2024 Jun 1;591:216883
Structural elucidation and anti-psoriasis activity of a novel polysaccharide from Saussurea Costus.
Gong X, Zhang Z, Shi X, Zhu Y, Ali F, Dong Y, Zhang F, Zhang B
Carbohydrate polymers 2024 Jun 1;333:121963
Carbohydrate polymers 2024 Jun 1;333:121963
Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.
Wang CY, Li MY, Li SY, Wei XG, Dong NX, Liu ST, Yuan ZW, Li B, Pierro A, Tang XB, Bai YZ
Cell proliferation 2024 Jul;57(7):e13618
Cell proliferation 2024 Jul;57(7):e13618
SHED-exos promote saliva secretion by suppressing p-ERK1/2-mediated apoptosis in glandular cells.
Chu WX, Ding C, Du ZH, Wei P, Wang YX, Ge XJ, Yu GY
Oral diseases 2024 Jul;30(5):3066-3080
Oral diseases 2024 Jul;30(5):3066-3080
LncRNA AC100826.1 regulated PLCB1 to promote progression in non-small cell lung cancer.
Dai S, Wang Q, Lyu Y, Chen Z, Liu X, Zhao G, Zhang H
Thoracic cancer 2024 Jul;15(19):1477-1489
Thoracic cancer 2024 Jul;15(19):1477-1489
GRP78 Downregulation in Keratinocytes Promotes Skin Inflammation through the Recruitment and Activation of CCR6(+) IL-17A-Producing γδ T Cells.
Zhao L, Li J, Jiang B, Yang J, Lan J, Li D, Wen J, Xia Y, Nie W, Wang Z, Lv Y, Zeng F, Li Y, Shen G, Lei P, Tao J
The Journal of investigative dermatology 2024 Jul;144(7):1557-1567.e11
The Journal of investigative dermatology 2024 Jul;144(7):1557-1567.e11
THSG alleviates cerebral ischemia/reperfusion injury via the GluN2B-CaMKII-ERK1/2 pathway.
Liu T, Shi J, Wu D, Li D, Wang Y, Liu J, Meng P, Hu L, Fu C, Mei Z, Ge J, Zhang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155595
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155595
Integration analysis of cell division cycle-associated family genes revealed potential mechanisms of gliomagenesis and constructed an artificial intelligence-driven prognostic signature.
Yu K, Tian Q, Feng S, Zhang Y, Cheng Z, Li M, Zhu H, He J, Li M, Xiong X
Cellular signalling 2024 Jul;119:111168
Cellular signalling 2024 Jul;119:111168
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
Yang Y, Zhao C, Yang Z, Du C, Chang Z, Wen X, Zhang X, Liu Y, Hu L, Gao Z
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Narirutin mitigates dextrose sodium sulfate-induced colitis in mice by modulating intestinal flora.
Xu D, Liu D, Jiang N, Xie Y, He D, Cheng J, Liu J, Fu S, Hu G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155730
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155730
Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats.
Yan Q, Liu H, Sun S, Yang Y, Fan D, Yang Y, Zhao Y, Song Z, Chen Y, Zhu R, Zhang Z
Journal of nanobiotechnology 2024 Jul 18;22(1):423
Journal of nanobiotechnology 2024 Jul 18;22(1):423
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
Li Y, Deng X, Hu Q, Chen Y, Zhang W, Qin X, Wei F, Lu X, Ma X, Zeng J, Efferth T
Journal of ethnopharmacology 2024 Jul 15;329:118107
Journal of ethnopharmacology 2024 Jul 15;329:118107
GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas.
Ren J, Cui Z, Jiang C, Wang L, Guan Y, Ren Y, Zhang S, Tu T, Yu J, Li Y, Duan W, Guan J, Wang K, Zhang H, Xing D, Kahn ML, Zhang H, Hong T
American journal of human genetics 2024 Jul 11;111(7):1370-1382
American journal of human genetics 2024 Jul 11;111(7):1370-1382
SETD8 inhibits apoptosis and ferroptosis of Ewing's sarcoma through YBX1/RAC3 axis.
Chen H, Hu J, Xiong X, Chen H, Liao Q, Lin B, Chen Y, Peng Y, Li Y, Cheng D, Li Z
Cell death & disease 2024 Jul 10;15(7):494
Cell death & disease 2024 Jul 10;15(7):494
Maternal high fat diet programs spatial learning and central leptin signaling in mouse offspring in a sex-specific manner.
Li Y, Yang Y, Ye B, Lin Y
Physiology & behavior 2024 Jul 1;281:114580
Physiology & behavior 2024 Jul 1;281:114580
Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.
Gao X, Long R, Qin M, Zhu W, Wei L, Dong P, Chen J, Luo J, Feng J
International journal of molecular medicine 2024 Jan;53(1)
International journal of molecular medicine 2024 Jan;53(1)
Amplifying T cell-mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti-PD1.
Gong B, Wang L, Zhang H, Wang Q, Li W
Cell biochemistry and function 2024 Jan;42(1):e3925
Cell biochemistry and function 2024 Jan;42(1):e3925
Inulin alters gut microbiota to alleviate post-stroke depressive-like behavior associated with the IGF-1-mediated MAPK signaling pathway.
Shao R, Tan X, Pan M, Huang J, Huang L, Bi B, Huang X, Wang J, Li X
Brain and behavior 2024 Jan;14(1):e3387
Brain and behavior 2024 Jan;14(1):e3387
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Cai Y, Yang H, Wan Z, Chen PY, Wang ZB, Guo JJ, Wang D, Wang F, Zhang Y
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca(2+) antagonism and maintaining mitochondrial function.
Shen G, Zhou Z, Guo Y, Li L, Zeng J, Wang J, Zhao J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117192
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117192
Polysaccharide from Artocarpus heterophyllus Lam. (Jackfruit) Pulp Ameliorates Dextran Sodium Sulfate-Induced Enteritis in Rats.
Li Y, Chen Y, Li C, Wu G, He Y, Tan L, Zhu K
International journal of molecular sciences 2024 Jan 29;25(3)
International journal of molecular sciences 2024 Jan 29;25(3)
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Huang C, Zhang Y, Xu Y, Wei S, Yang T, Wang S, Li C, Lin H, Li X, Zhao S, Zhu L, Pan W
Aging 2024 Jan 26;16(3):2362-2384
Aging 2024 Jan 26;16(3):2362-2384
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Wu W, Li G, Dong S, Huihan Chu C, Ma S, Zhang Z, Yuan S, Wu J, Guo Z, Shen Y, Wang J, Tang C
International immunopharmacology 2024 Jan 25;127:111423
International immunopharmacology 2024 Jan 25;127:111423
Investigation of Tongxie-Yaofang formula in treating ulcerative colitis based on network pharmacology via regulating MAPK/AKT signaling pathway.
Liu X, Ye M, He Y, Lai Q, Liu B, Zhang L
Aging 2024 Jan 24;16(2):1911-1924
Aging 2024 Jan 24;16(2):1911-1924
Bioinformatics and experimental studies jointly reveal that Sacubitril Valsartan improves myocardial oxidative stress and inflammation by regulating the MAPK signaling pathway to treat chemotherapy related cardiotoxicity.
Shi H, Lu H, Zheng Y, Pu P, Wei L, Hu D, Tang H, Wang L
Biochemical and biophysical research communications 2024 Jan 1;690:149244
Biochemical and biophysical research communications 2024 Jan 1;690:149244
Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway.
Wu Z, Liu Q, Cao Z, Li H, Zhou Y, Zhang P
Immunopharmacology and immunotoxicology 2024 Feb;46(1):86-92
Immunopharmacology and immunotoxicology 2024 Feb;46(1):86-92
Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK/NF-κB pathways.
Lu C, Li X, Du W, Zhang X, Li Y, Hu C, Mao Z, Zhang Y, Wang R
Bioorganic chemistry 2024 Feb;143:107054
Bioorganic chemistry 2024 Feb;143:107054
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Luan X, Lei T, Fang J, Liu X, Fu H, Li Y, Chu W, Jiang P, Tong C, Qi H, Fu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice.
He D, Gao X, Wen J, Zhang Y, Yang S, Sun X, Cui M, Li Z, Fu S, Liu J, Liu D
Food & function 2024 Feb 5;15(3):1460-1475
Food & function 2024 Feb 5;15(3):1460-1475
Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts.
Zuo J, Ma S
Heliyon 2024 Feb 29;10(4):e24985
Heliyon 2024 Feb 29;10(4):e24985
Bufei Yishen formula protects the airway epithelial barrier and ameliorates COPD by enhancing autophagy through the Sirt1/AMPK/Foxo3 signaling pathway.
Jia L, Liu X, Liu X, Guan Q, Tian Y, Li J, Zhao P
Chinese medicine 2024 Feb 28;19(1):32
Chinese medicine 2024 Feb 28;19(1):32
BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response.
Ji R, Zhang Z, Yang Z, Chen X, Yin T, Yang J
Cellular and molecular life sciences : CMLS 2024 Feb 27;81(1):101
Cellular and molecular life sciences : CMLS 2024 Feb 27;81(1):101
An Inulin-Type Fructan CP-A from Codonopsis pilosula Alleviated 5-Fluorouracil-Induced Intestinal Mucositis via the ERK/MLCK/MLC2 Pathway and Regulation of Gut Microbiota.
Zhou J, Li D, Wang J, Cheng Z, Wang C, Zhang X, Xu X, Gao J
Pharmaceuticals (Basel, Switzerland) 2024 Feb 26;17(3)
Pharmaceuticals (Basel, Switzerland) 2024 Feb 26;17(3)
JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway.
Li Z, He R, Liu J, Jin X, Jiang B, Lao Y, Yang S
BMC complementary medicine and therapies 2024 Feb 24;24(1):101
BMC complementary medicine and therapies 2024 Feb 24;24(1):101
Puerarin Ameliorated PCOS through Preventing Mitochondrial Dysfunction Dependent on the Maintenance of Intracellular Calcium Homeostasis.
Wang YS, Li BY, Xing YF, Huang JC, Chen ZS, Yue L, Zou YG, Guo B
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2963-2976
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2963-2976
Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer.
Chen Y, Qiang Y, Fan J, Zheng Q, Yan L, Fan G, Song X, Zhang N, Lv Q, Xiong J, Wang J, Cao J, Liu Y, Xiong J, Zhang W, Li F
Nature communications 2024 Feb 13;15(1):1321
Nature communications 2024 Feb 13;15(1):1321
Sasanquasaponin from Camellia oleifera Abel Exerts an Anti-Inflammatory Effect in RAW 264.7 Cells via Inhibition of the NF-κB/MAPK Signaling Pathways.
Zhao Y, Zhao N, Kollie L, Yang D, Zhang X, Zhang H, Liang Z
International journal of molecular sciences 2024 Feb 10;25(4)
International journal of molecular sciences 2024 Feb 10;25(4)
Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells.
Xia L, Liu JY, Yang MY, Zhang XH, Jiang Y, Yin QQ, Luo CH, Liu HC, Kang ZJ, Zhang CT, Gao BB, Zhou AW, Cai HY, Waller EK, Yan JS, Lu Y
Cancer research 2024 Feb 1;84(3):479-492
Cancer research 2024 Feb 1;84(3):479-492
CP41, a novel curcumin analogue, induces apoptosis in endometrial cancer cells by activating the H3F3A/ proteasome-MAPK signaling pathway and enhancing oxidative stress.
Zhang MJ, Shi M, Yu Y, Wang H, Ou R, Ge RS
Life sciences 2024 Feb 1;338:122406
Life sciences 2024 Feb 1;338:122406
Therapeutic potential of Lacticaseibacillus rhamnosus grx10 and its derived postbiotic through gut microbiota and MAPK/MLCK/MLC pathway-mediated intestinal barrier repairment in ulcerative colitis.
Ye H, Liu X, Guan K, Ma Y, Liu R, Liu Y, Lv X, Wang R, Li Q
Journal of food science 2024 Dec;89(12):10035-10052
Journal of food science 2024 Dec;89(12):10035-10052
Amphotericin B for injection triggers degranulation of human LAD2 mast cells by MRGPRX2 and pseudo-allergic reactions in mice via MRGPRB2 activation.
He X, Yang X, Qin L, Zhang Q, Ji X, Tang W, Zhan Y, Zhang Y
Immunologic research 2024 Dec;72(6):1337-1349
Immunologic research 2024 Dec;72(6):1337-1349
Peptidylprolyl isomerase D circular RNA sensitizes breast cancer to trastuzumab through remodeling HER2 N4-acetylcytidine modification.
Wang S, Li Q, Wang Y, Li X, Feng X, Wei Y, Wang J, Zhou X
Journal of applied genetics 2024 Dec;65(4):797-807
Journal of applied genetics 2024 Dec;65(4):797-807
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.
Gao S, Cheng Q, Hu Y, Fan X, Liang C, Niu C, Kang Q, Wei T
Molecular and cellular biochemistry 2024 Dec;479(12):3393-3404
Molecular and cellular biochemistry 2024 Dec;479(12):3393-3404
G protein-coupled receptor kinase 2 as a novel therapeutic target for gland fibrosis of Sjögren's syndrome.
Fang RH, Zhou ZW, Chu R, Guan QY, He F, Ge ML, Guo PP, Wu HX, Yao LL, Wei W, Ma Y, Wang QT
Acta pharmacologica Sinica 2024 Dec;45(12):2611-2624
Acta pharmacologica Sinica 2024 Dec;45(12):2611-2624
Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model.
Xie Y, Xu H, Gu Z
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2024 Dec;44(1):2337691
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2024 Dec;44(1):2337691
Folic acid mitigates the developmental and neurotoxic effects of bisphenol A in zebrafish by inhibiting the oxidative stress/JNK signaling pathway.
Li R, Yang W, Yan X, Zhou X, Song X, Liu C, Zhang Y, Li J
Ecotoxicology and environmental safety 2024 Dec;288:117363
Ecotoxicology and environmental safety 2024 Dec;288:117363
SPRY4 regulates ERK1/2 phosphorylation to affect oxidative stress and steroidogenesis in polycystic ovary syndrome.
Pan Y, Yang C, Sun Y, Zhang S, Xue T, Li F, Fu D
Steroids 2024 Dec;212:109516
Steroids 2024 Dec;212:109516
CTGF regulated by ATF6 inhibits vascular endothelial inflammation and reduces hepatic ischemia-reperfusion injury.
Yang DJ, Bai Y, Wu M, Liang YM, Zhou BH, Guo W, Zhang SJ, Shi JH
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167490
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167490
Molecular mechanism through which Tripterygium hypoglaucum (Lévl.) Hutch alleviates psoriasis.
Sun Y, Wang J, Hu P, Tang Y, Wang Y, Ye J, Yang X, Yin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Dec;181:117647
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Dec;181:117647
Proteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection.
Jiang N, Chen Y, Li T, Sun Y, Su Y, Wang Y, Shen Y, Cao J
PLoS neglected tropical diseases 2024 Dec;18(12):e0012659
PLoS neglected tropical diseases 2024 Dec;18(12):e0012659
Inhibition of JNK/STAT3/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin.
Lv Z, Du Y, Zhang H, Fang H, Guo Y, Zeng L, Chen Y, Li D, Li R
Cell adhesion & migration 2024 Dec;18(1):27-37
Cell adhesion & migration 2024 Dec;18(1):27-37
Baliosperoid A attenuates lipopolysaccharide-induced acute lung injury by targeting SHP2 to inhibit inflammation and oxidative stress.
Li Y, Zhao L, Liu Z, Chen Y, Li X, Zhu D, Liu L
Bioorganic chemistry 2024 Dec;153:107982
Bioorganic chemistry 2024 Dec;153:107982
Inhibiting TRIM8 alleviates adipocyte inflammation and insulin resistance by regulating the DUSP14/MAPKs pathway.
Zhu M, Pu J, Zhang T, Shao H, Su R, Tang C
Adipocyte 2024 Dec;13(1):2381262
Adipocyte 2024 Dec;13(1):2381262
Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption.
Ouyang F, Li Y, Wang H, Liu X, Tan X, Xie G, Zeng J, Zeng G, Luo Q, Zhou H, Chen S, Hou K, Fang J, Zhang X, Zhou L, Li Y, Gao A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2406026
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2406026
Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.
Ma Z, Chen X, Xiong M, Wang H, Sun C, Tang W, Li J, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Dec 5;335:118644
Journal of ethnopharmacology 2024 Dec 5;335:118644
Quercetin-primed BMSC-derived extracellular vesicles ameliorate chronic liver damage through miR-136-5p and GNAS/STAT3 signaling pathways.
Jiang X, Liu Z, You H, Tang Z, Ma Y, Nie R, Yang Z, Che N, Liu W
International immunopharmacology 2024 Dec 5;142(Pt B):113162
International immunopharmacology 2024 Dec 5;142(Pt B):113162
RG108 attenuates acute kidney injury by inhibiting P38 MAPK/FOS and JNK/JUN pathways.
Kong FX, Liu H, Xu T, Li SJ, Li W, Lu H, Ma NN, Wang YL, Shi JH, Yang YR, Wang FL
International immunopharmacology 2024 Dec 5;142(Pt A):113077
International immunopharmacology 2024 Dec 5;142(Pt A):113077
NLRP12 c.1382dup promotes the development of Crohn's disease through the ERK/NLRP3/ IL-1β pathway.
Huang Y, Xu L, Yang Q, Xiao X, Ye Z, Li R, Guan Y, Wu X
Gene 2024 Dec 30;931:148855
Gene 2024 Dec 30;931:148855
Integrated multi-omics analysis and machine learning developed diagnostic markers and prognostic model based on Efferocytosis-associated signatures for septic cardiomyopathy.
Li X, Jiang S, Wang B, He S, Guo X, Lin J, Wei Y
Clinical immunology (Orlando, Fla.) 2024 Aug;265:110301
Clinical immunology (Orlando, Fla.) 2024 Aug;265:110301
Extracellular vesicles miR-31-5p promotes pancreatic cancer chemoresistance via regulating LATS2-Hippo pathway and promoting SPARC secretion from pancreatic stellate cells.
Qin C, Zhao B, Wang Y, Li Z, Li T, Zhao Y, Wang W, Zhao Y
Journal of extracellular vesicles 2024 Aug;13(8):e12488
Journal of extracellular vesicles 2024 Aug;13(8):e12488
TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.
Gao Y, Hou J, Fei X, Ren L, Lu R, Liu P, Liu S, Zhu C, Wang X, Pan Y
Cellular signalling 2024 Aug;120:111227
Cellular signalling 2024 Aug;120:111227
mRNA-Lipid Nanoparticle-Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple-Negative Breast Cancer.
Li W, Huang M, Wu Z, Zhang Y, Cai Y, Su J, Xia J, Yang F, Xiao D, Yang W, Xu Y, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2309988
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2309988
Targeted treatment of rat AKI induced by rhabdomyolysis using BMSC derived magnetic exosomes and its mechanism.
Chen Y, Hou S
Nanoscale advances 2024 Aug 6;6(16):4180-4195
Nanoscale advances 2024 Aug 6;6(16):4180-4195
Mahuang Fuzi Xixin decoction: A potent analgesic for neuropathic pain targeting the NMDAR2B/CaMKIIα/ERK/CREB pathway.
Chai Y, He S, Liang D, Gu C, Gong Q, Long L, Chen P, Wang L
Heliyon 2024 Aug 30;10(16):e35970
Heliyon 2024 Aug 30;10(16):e35970
Network Pharmacological Analysis Combined with Experimental Verification to Explore the Effect of Ginseng Polypeptide on the Improvement of Diabetes Symptoms in db/db Mice.
Liu T, Zhu C, Duan Z, Ma P, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Aug 21;72(33):18537-18551
Journal of agricultural and food chemistry 2024 Aug 21;72(33):18537-18551
miR-450a-2-3p targets ERK(1/2) to ameliorate ISO-induced cardiac fibrosis in mice.
Liu L, Luo F
Genes & nutrition 2024 Aug 19;19(1):16
Genes & nutrition 2024 Aug 19;19(1):16
Development of new dehydrocostuslactone derivatives for treatment of atopic dermatitis via inhibition of the NF-κB signaling pathway.
Li X, Lu C, Du W, Zou Q, Wang R, Hu C, Li Y, Zhang Y, Mao Z
RSC medicinal chemistry 2024 Aug 14;15(8):2773-2784
RSC medicinal chemistry 2024 Aug 14;15(8):2773-2784
Targeting AGTPBP1 inhibits pancreatic cancer progression via regulating microtubules and ERK signaling pathway.
Li DZ, Yang ZY, Leng A, Zhang Q, Zhang XD, Bian YC, Xiao R, Ren JJ
Molecular medicine (Cambridge, Mass.) 2024 Aug 11;30(1):119
Molecular medicine (Cambridge, Mass.) 2024 Aug 11;30(1):119
RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition.
Dong W, Li X, Cheng L, Yang J, Zhao Z, Qiang X, Li P, Wu J, Guo L
Archives of biochemistry and biophysics 2024 Apr;754:109896
Archives of biochemistry and biophysics 2024 Apr;754:109896
Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species.
Zhao H, Zhao H, Li M, Tang Y, Xiao X, Cai Y, He F, Huang H, Zhang Y, Li J
Redox biology 2024 Apr;70:103055
Redox biology 2024 Apr;70:103055
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis.
Zhao C, Yu Y, Yin G, Xu C, Wang J, Wang L, Zhao G, Ni S, Zhang H, Zhou B, Wang Y
Inflammopharmacology 2024 Apr;32(2):1277-1294
Inflammopharmacology 2024 Apr;32(2):1277-1294
A TGF-β signaling-related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response.
Duan WW, Yang LT, Liu J, Dai ZY, Wang ZY, Zhang H, Zhang X, Liang XS, Luo P, Zhang J, Liu ZQ, Zhang N, Mo HY, Qu CR, Xia ZW, Cheng Q
CNS neuroscience & therapeutics 2024 Apr;30(4):e14489
CNS neuroscience & therapeutics 2024 Apr;30(4):e14489
Discovery of a Pimaradiene that Decreases Viability of MDA-MB-468 Cells Through Inhibition of EGFR Signaling Pathway.
Wang N, Qin L, Liu Z, Cao J, Huang J, Ma L, Huang G
Chemistry & biodiversity 2024 Apr;21(4):e202400288
Chemistry & biodiversity 2024 Apr;21(4):e202400288
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
Chen L, Wang J, Ren Y, Ma Y, Liu J, Jiang H, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
The prenatal use of agmatine prevents social behavior deficits in VPA-exposed mice by activating the ERK/CREB/BDNF signaling pathway.
Chen S, Xu Q, Zhao L, Zhang M, Xu H
Birth defects research 2024 Apr;116(4):e2336
Birth defects research 2024 Apr;116(4):e2336
H(2)S-Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation.
Jin T, Lu H, Zhou Q, Chen D, Zeng Y, Shi J, Zhang Y, Wang X, Shen X, Cai X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2308092
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2308092
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Wang Z, Dong Z, Li Y, Jiao X, Liu Y, Chang H, Gan Y
Biomedicines 2024 Apr 18;12(4)
Biomedicines 2024 Apr 18;12(4)
FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation.
Yuan Z, Yang L, Li Y, Li X, Peng C, Pan J, Cai D
BMC musculoskeletal disorders 2024 Apr 12;25(1):282
BMC musculoskeletal disorders 2024 Apr 12;25(1):282
Oxidative stress-induced temporal activation of ERK1/2 phosphorylates coreceptor of Wnt/β-catenin for myofibroblast formation in human lens epithelial cells.
Guo Z, Ma X, Chen X, Zhang RX, Yan H
Molecular vision 2023;29:206-216
Molecular vision 2023;29:206-216
BIBF1120 Protects against Diabetic Retinopathy through Neovascularization-Related Molecules and the MAPK Signaling Pathway.
Cao X, Li T, Tian Y, Tian Y, Gao C, Zhang D, Song Y
Journal of ophthalmology 2023;2023:7355039
Journal of ophthalmology 2023;2023:7355039
Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways.
Chen X, Lin L, Wu Q, Li S, Wang H, Sun Y
Mediators of inflammation 2023;2023:5679966
Mediators of inflammation 2023;2023:5679966
Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and Promotes Apoptosis and Autophagy of Gastric Cancer Cells.
Zhu L, Yao Z, Luo Q, Liu Y, Zhao W, Shao C, Shao S, Cui F
International journal of medical sciences 2023;20(8):1038-1045
International journal of medical sciences 2023;20(8):1038-1045
Suppression of migration and invasion by taraxerol in the triple-negative breast cancer cell line MDA-MB-231 via the ERK/Slug axis.
Xia YT, Zhang YQ, Chen L, Min L, Huang D, Zhang Y, Li C, Li ZH
PloS one 2023;18(9):e0291693
PloS one 2023;18(9):e0291693
Establishment of Risk Model and Analysis of Immunoinfiltration Based on Mitophagy-Related Associated Genes in Atrial Fibrillation.
Sang W, Wang L, Yan X, Sun H, Han Y, Wang F, Tang B, Li Y
Journal of inflammation research 2023;16:2561-2583
Journal of inflammation research 2023;16:2561-2583
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.
Yang HW, Lan Y, Li A, Wu H, Song ZW, Wan AL, Wang Y, Li SB, Ji S, Wang ZC, Wu XY, Lan T
Frontiers in pharmacology 2023;14:1288883
Frontiers in pharmacology 2023;14:1288883
Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt's lymphoma cells by inhibiting AKT and ERK.
Yuan-Ce L, Qi Z, Hong-Yang Z, Yan-Wen W, Yu-Mei S, Bi-Juan Y, Jun-Lin Y
Frontiers in pharmacology 2023;14:1218467
Frontiers in pharmacology 2023;14:1218467
Exploration of the mechanism of aloin ameliorates of combined allergic rhinitis and asthma syndrome based on network pharmacology and experimental validation.
Feng Y, Qiao H, Liu H, Wang J, Tang H
Frontiers in pharmacology 2023;14:1218030
Frontiers in pharmacology 2023;14:1218030
Supramolecular nanofibers co-loaded with dabrafenib and doxorubicin for targeted and synergistic therapy of differentiated thyroid carcinoma.
Chen P, Cai X, Mu G, Duan Y, Jing C, Yang Z, Yang C, Wang X
Theranostics 2023;13(7):2140-2153
Theranostics 2023;13(7):2140-2153
Copine 7 promotes colorectal cancer proliferation through PKM2 interaction and MAPK signaling pathway.
Yu T, Huang C, Lai C, He Q, Yuan W, Chen Z
Frontiers in oncology 2023;13:1166444
Frontiers in oncology 2023;13:1166444
The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin.
Zhou Y, Bai R, Huang Y, Li W, Chen J, Cheng Z, Wu X, Diao Y
Frontiers in bioengineering and biotechnology 2023;11:1229387
Frontiers in bioengineering and biotechnology 2023;11:1229387
Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance.
Hu HF, Gao GB, He X, Li YY, Li YJ, Li B, Pan Y, Wang Y, He QY
Journal of advanced research 2023 Sep;51:135-147
Journal of advanced research 2023 Sep;51:135-147
A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement.
Shen X, Wu W, Ying Y, Zhou L, Zhu H
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc 2023 Sep;49 Suppl 1:228-237
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc 2023 Sep;49 Suppl 1:228-237
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization.
Liu Y, Zhou Q, Ye F, Yang C, Jiang H
Neoplasia (New York, N.Y.) 2023 Sep;43:100928
Neoplasia (New York, N.Y.) 2023 Sep;43:100928
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Wen H, Qu C, Wang Z, Gao H, Liu W, Wang H, Sun H, Gu J, Yang Z, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
Yueju volatile oil plays an integral role in the antidepressant effect by up-regulating ERK/AKT-mediated GLT-1 expression to clear glutamate.
Zhang B, Su D, Song Y, Li H, Chen C, Liao L, Zhang H, Luo J, Yang M, Zhu G, Ai Z
Fitoterapia 2023 Sep;169:105583
Fitoterapia 2023 Sep;169:105583
Oridonin inhibits the occurrence and development of colorectal cancer by reversing the Warburg effect via reducing PKM2 dimer formation and preventing its entry into the nucleus.
Chen F, Liao J, Wu P, Cheng L, Ma Y, Zhang L, Leng X, Zhu X, Liu Z, Xie F
European journal of pharmacology 2023 Sep 5;954:175856
European journal of pharmacology 2023 Sep 5;954:175856
Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
Luo D, Liang Y, Wang Y, Ye F, Jin Y, Li Y, Han D, Wang Z, Chen B, Zhao W, Wang L, Chen X, Jiang L, Yang Q
Breast cancer research : BCR 2023 Sep 28;25(1):109
Breast cancer research : BCR 2023 Sep 28;25(1):109
Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.
Zhao Z, Li Y, Guo S, Chen Y, Yin H, Li Y, Cheng G, Tian L
International journal of molecular sciences 2023 Sep 25;24(19)
International journal of molecular sciences 2023 Sep 25;24(19)
Long-Term Exposure to Microcystin-LR Induces Gastric Toxicity by Activating the Mitogen-Activated Protein Kinase Signaling Pathway.
Liu Y, Li Y, Tan Q, Lv Y, Tang Y, Yang Y, Yao X, Yang F
Toxins 2023 Sep 18;15(9)
Toxins 2023 Sep 18;15(9)
Inhibition of FNDC1 suppresses gastric cancer progression by interfering with Gβγ-VEGFR2 complex formation.
Lu Y, Huang P, Zeng X, Liu W, Zhao R, Li J, Cao G, Hu Y, Xiao Q, Wu M, Huang W, Tang X, Liu X, Wei H
iScience 2023 Sep 15;26(9):107534
iScience 2023 Sep 15;26(9):107534
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Zhang L, Liang S, Zhang Z, Wang K, Cao J, Yao M, Qin L, Qu C, Miao J
International journal of molecular sciences 2023 Sep 12;24(18)
International journal of molecular sciences 2023 Sep 12;24(18)
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Yang Z, Wu S, He S, Han L, Zhou M, Yang J, Chen J, Wu G
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
Formin-related protein 1 facilitates proliferation and aggressive phenotype of clear cell renal cell carcinoma through MAPK/MMP2 pathway.
Ma G, Zhang B, Fu S, Lu J, Zhang L, Shang P, Yue Z
Molecular and cellular probes 2023 Oct;71:101921
Molecular and cellular probes 2023 Oct;71:101921
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Huangfu N, Ma H, Tian M, Zhang J, Wang Y, Li Z, Chen X, Cui H
Inflammation 2023 Oct;46(5):1725-1738
Inflammation 2023 Oct;46(5):1725-1738
Identification of a receptor tyrosine kinase inhibitor CP-724714 inhibits SADS-CoV related swine diarrhea coronaviruses infection in vitro.
Zhou L, Li C, Zhang R, Li Q, Sun Y, Feng Y, Lan T, Ma J
Virologica Sinica 2023 Oct;38(5):778-786
Virologica Sinica 2023 Oct;38(5):778-786
HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway.
Zhao B, Qiao H, Zhao Y, Gao Z, Wang W, Cui Y, Li J, Guo Z, Chuai X, Chiu S
Virologica Sinica 2023 Oct;38(5):680-689
Virologica Sinica 2023 Oct;38(5):680-689
Lens epithelial cell-derived exosome inhibits angiogenesis in ocular pathological neovascularization through its delivery of miR-146a-5p.
Pan T, Wu Y, Zhang X, Wang J, Wang X, Gu Q, Xu C, Fan Y, Li X, Xie P, Liu Q, Hu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23192
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23192
Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus.
Su Z, Lu J, Ling Z, Li W, Yang X, Cheng B, Tao X
Biochemical pharmacology 2023 Oct;216:115796
Biochemical pharmacology 2023 Oct;216:115796
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Ma Y, Zhang J, Li Y, Hu H, Ye Q, Yang C, Yang L, Zhang B, Ma T
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Meng M, Wang L, Yao Y, Lin D, Wang C, Yao J, Sun H, Liu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Transcriptome Analysis Revealed Potential Genes of Skeletal Muscle Thermogenesis in Mashen Pigs and Large White Pigs under Cold Stress.
Li W, Chen Y, Zhang Y, Zhao N, Zhang W, Shi M, Zhao Y, Cai C, Lu C, Gao P, Guo X, Li B, Kim SW, Yang Y, Cao G
International journal of molecular sciences 2023 Oct 24;24(21)
International journal of molecular sciences 2023 Oct 24;24(21)
FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke.
Guan X, Wei D, Liang Z, Xie L, Wang Y, Huang Z, Wu J, Pang T
ACS chemical neuroscience 2023 Oct 18;14(20):3839-3854
ACS chemical neuroscience 2023 Oct 18;14(20):3839-3854
Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation.
Kanwore K, Kanwore K, Guo X, Xia Y, Zhou H, Zhang L, Adzika GK, Joseph AA, Abiola AA, Mu P, Kambey PA, Noah MLN, Gao D
Inflammation and regeneration 2023 Oct 13;43(1):49
Inflammation and regeneration 2023 Oct 13;43(1):49
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Ke W, Wang B, Liao Z, Song Y, Li G, Ma L, Wang K, Li S, Hua W, Yang C
Journal of translational medicine 2023 Oct 10;21(1):711
Journal of translational medicine 2023 Oct 10;21(1):711
Multi-omics reveals aging-related pathway in natural aging mouse liver.
Tang CM, Zhang Z, Sun Y, Ding WJ, Yang XC, Song YP, Ling MY, Li XH, Yan R, Zheng YJ, Yu N, Zhang WH, Wang Y, Wang SP, Gao HQ, Zhao CL, Xing YQ
Heliyon 2023 Nov;9(11):e21011
Heliyon 2023 Nov;9(11):e21011
Ketamine counteracts sevoflurane-induced depressive-like behavior and synaptic plasticity impairments through the adenosine A2A receptor/ERK pathway in rats.
Yu W, Wu Z, Li X, Ding M, Xu Y, Zhao P
Molecular neurobiology 2023 Nov;60(11):6160-6175
Molecular neurobiology 2023 Nov;60(11):6160-6175
Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation.
Ge Z, Xu M, Ge Y, Huang G, Chen D, Ye X, Xiao Y, Zhu H, Yin R, Shen H, Ma G, Qi L, Wei G, Li D, Wei S, Zhu M, Ma H, Shi Z, Wang X, Ge X, Qian X
Cell reports 2023 Nov 28;42(11):113417
Cell reports 2023 Nov 28;42(11):113417
Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling.
Xia L, Zhang T, Yao J, Lu K, Hu Z, Gu X, Chen Y, Qin S, Leng W
iScience 2023 Nov 17;26(11):108201
iScience 2023 Nov 17;26(11):108201
The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection.
Li Y, Cao H, Qiu D, Wang N, Wang Y, Wen T, Wang J, Zhu H
Cancer cell international 2023 Nov 16;23(1):272
Cancer cell international 2023 Nov 16;23(1):272
Study on the Alleviating Effect and Potential Mechanism of Ethanolic Extract of Limonium aureum (L.) Hill. on Lipopolysaccharide-Induced Inflammatory Responses in Macrophages.
Yang Z, Man J, Liu Y, Zhang H, Wu D, Shao D, Hao B, Wang S
International journal of molecular sciences 2023 Nov 13;24(22)
International journal of molecular sciences 2023 Nov 13;24(22)
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
Zhang F, Zou H, Li X, Liu J, Xie Y, Chen M, Yu J, Wu X, Guo B
Human cell 2023 May;36(3):1024-1040
Human cell 2023 May;36(3):1024-1040
N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
Wang J, Yu H, Dong W, Zhang C, Hu M, Ma W, Jiang X, Li H, Yang P, Xiang D
Gastroenterology 2023 May;164(6):990-1005
Gastroenterology 2023 May;164(6):990-1005
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Wang Z, Tan M, Su W, Huang W, Zhang J, Jia F, Cao G, Liu X, Song H, Ran H, Nie G, Wang H
Journal of medicinal chemistry 2023 May 11;66(9):6263-6273
Journal of medicinal chemistry 2023 May 11;66(9):6263-6273
An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma.
Si Z, Yang G, Wang X, Yu Z, Pang Q, Zhang S, Qian L, Ruan Y, Huang J, Yu L
Life science alliance 2023 Mar;6(3)
Life science alliance 2023 Mar;6(3)
Methionine sulfoxide suppresses adipogenic differentiation by regulating the mitogen-activated protein kinase signaling pathway.
Qin D, Lei Y, Xie W, Zheng Q, Peng Z, Liu Y, Dai B, Ma T, Wei P, Gao C, Guo X, Gao J, Zhao J, Du J, Zeng Q, Zhang Z, Dong X, Shen H
Cell biology international 2023 Mar;47(3):648-659
Cell biology international 2023 Mar;47(3):648-659
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.
He XY, Zhu MM, Zheng J, Wang CY, Zhao XK, Zhang BT, Zhou DC, Zhang S, Yang XX, Duan YJ, Han JH, Chen YL
Acta pharmacologica Sinica 2023 Mar;44(3):635-646
Acta pharmacologica Sinica 2023 Mar;44(3):635-646
The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis.
Wang Y, Peng M, Zhong Y, Xiong W, Zhu L, Jin X
Oncogene 2023 Mar;42(13):952-966
Oncogene 2023 Mar;42(13):952-966
Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.
Zhang L, Ma X, Shi R, Zhang L, Zhao R, Duan R, Qin Y, Gao S, Li X, Duan J, Li J
British journal of pharmacology 2023 Mar;180(5):628-646
British journal of pharmacology 2023 Mar;180(5):628-646
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation.
Ning W, Gao G, Zhou Y, Li WQ, Yang HH, Duan XB, Li X, Gong YB, Li D, Guo R
International immunopharmacology 2023 Mar;116:109747
International immunopharmacology 2023 Mar;116:109747
Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway.
Li Y, He B, Zhang C, He Y, Xia T, Zeng C
Nutrients 2023 Mar 9;15(6)
Nutrients 2023 Mar 9;15(6)
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway.
Zhao L, Miao Y, Shan B, Zhao C, Peng C, Gong J
Foods (Basel, Switzerland) 2023 Mar 30;12(7)
Foods (Basel, Switzerland) 2023 Mar 30;12(7)
Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation.
Cheng X, Jia X, Wang C, Zhou S, Chen J, Chen L, Chen J
World journal of surgical oncology 2023 Mar 28;21(1):112
World journal of surgical oncology 2023 Mar 28;21(1):112
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways.
Wang Z, Jian G, Chen T, Chen Y, Li J, Wang N
European journal of histochemistry : EJH 2023 Mar 1;67(1)
European journal of histochemistry : EJH 2023 Mar 1;67(1)
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.
Shao L, Wu B, Liu C, Chong W
Shock (Augusta, Ga.) 2023 Mar 1;59(3):449-459
Shock (Augusta, Ga.) 2023 Mar 1;59(3):449-459
Chitosan targets PI3K/Akt/FoxO3a axis to up-regulate FAM172A and suppress MAPK/ERK pathway to exert anti-tumor effect in osteosarcoma.
Ren Z, Xiao W, He M, Bai L
Chemico-biological interactions 2023 Mar 1;373:110354
Chemico-biological interactions 2023 Mar 1;373:110354
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
Li L, Wang X, Hu K, Liu X, Qiu L, Bai C, Cui Y, Wang B, Wang Z, Wang H, Cheng R, Hua J, Hai L, Wang M, Liu M, Song Z, Xiao C, Li B
Oncogene 2023 Jun;42(27):2166-2182
Oncogene 2023 Jun;42(27):2166-2182
Exercise-induced endothelial Mecp2 lactylation suppresses atherosclerosis via the Ereg/MAPK signalling pathway.
Wang Y, Chen L, Zhang M, Li X, Yang X, Huang T, Ban Y, Li Y, Li Q, Zheng Y, Sun Y, Wu J, Yu B
Atherosclerosis 2023 Jun;375:45-58
Atherosclerosis 2023 Jun;375:45-58
Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex.
Gu L, Jin X, Liang H, Yang C, Zhang Y
Pharmacological research 2023 Jun;192:106789
Pharmacological research 2023 Jun;192:106789
The Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple.
Che R, Liu C, Wang Q, Tu W, Wang P, Li C, Gong X, Mao K, Feng H, Huang L, Li P, Ma F
Autophagy 2023 Jun;19(6):1745-1763
Autophagy 2023 Jun;19(6):1745-1763
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway.
Wu Y, Duan Z, Qu L, Zhang Y, Zhu C, Fan D
Food & function 2023 Jun 6;14(11):5167-5181
Food & function 2023 Jun 6;14(11):5167-5181
Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production.
Yan Y, Yang X, Han N, Liu Y, Liang Q, Li LG, Hu J, Li TF, Xu Z
Journal of nanobiotechnology 2023 Jun 29;21(1):204
Journal of nanobiotechnology 2023 Jun 29;21(1):204
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
Jiang Q, Lei Z, Wang Z, Wang Q, Zhang Z, Liu X, Xing B, Li S, Guo X, Liu Y, Li X, Qi Y, Shu K, Zhang H, Huang Y, Lei T
Cancers 2023 Jun 27;15(13)
Cancers 2023 Jun 27;15(13)
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Cai Y, Chen P, Xu H, Li S, Zhao B, Fan Y, Wang F, Zhang Y
International journal of molecular sciences 2023 Jun 26;24(13)
International journal of molecular sciences 2023 Jun 26;24(13)
Endothelial progenitor cell-derived exosomes inhibit pulmonary artery smooth muscle cell in vitro proliferation and resistance to apoptosis by modulating the Mitofusin-2 and Ras-Raf-ERK1/2 signaling pathway.
Liu P, Gao S, Li Z, Pan S, Luo G, Ji Z
European journal of pharmacology 2023 Jun 15;949:175725
European journal of pharmacology 2023 Jun 15;949:175725
Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia.
Mishima S, Mitsui T, Tani K, Ooba H, Mitoma T, Ohira A, Maki J, Kirino S, Eto E, Hayata K, Masuyama H
Placenta 2023 Jul;138:44-50
Placenta 2023 Jul;138:44-50
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Deng X, Zeng Y, Qiu X, Zhong M, Xiong X, Luo M, Zhang J, Chen X
Leukemia research 2023 Jul;130:107312
Leukemia research 2023 Jul;130:107312
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Shen PC, Huang SH, Liu ZM, Lu CC, Chou SH, Tien YC
International immunopharmacology 2023 Jul;120:110295
International immunopharmacology 2023 Jul;120:110295
Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice.
Du J, Zhang F, Chen M, Xiao Y, Zhang L, Dong L, Dong D, Wu B
The Journal of pharmacy and pharmacology 2023 Jul 5;75(7):886-897
The Journal of pharmacy and pharmacology 2023 Jul 5;75(7):886-897
A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer.
Song R, Guo P, Ren X, Zhou L, Li P, Rahman NA, Wołczyński S, Li X, Zhang Y, Liu M, Liu J, Li X
Molecular cancer 2023 Jul 5;22(1):104
Molecular cancer 2023 Jul 5;22(1):104
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Jie Li Z, Bing Luo C, Liang Wang H, Sun J, Qian Yang Q, Lang Zhou Y
International journal of pharmaceutics 2023 Jul 25;642:123190
International journal of pharmaceutics 2023 Jul 25;642:123190
Elevated retinal fibrosis in experimental myopia is involved in the activation of the PI3K/AKT/ERK signaling pathway.
Bao B, Liu J, Li T, Yang Z, Wang G, Xin J, Bi H, Guo D
Archives of biochemistry and biophysics 2023 Jul 15;743:109663
Archives of biochemistry and biophysics 2023 Jul 15;743:109663
Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.
Wan Q, Xu J, Zhu C, Liu X, Tu Y, Lei J, Yu J
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10349-10360
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10349-10360
Resveratrol May Reduce the Degree of Periodontitis by Regulating ERK Pathway in Gingival-Derived MSCs.
Jiang H, Ni J, Hu L, Xiang Z, Zeng J, Shi J, Chen Q, Li W
International journal of molecular sciences 2023 Jul 10;24(14)
International journal of molecular sciences 2023 Jul 10;24(14)
TRPC6 promotes daunorubicin-induced mitochondrial fission and cell death in rat cardiomyocytes with the involvement of ERK1/2-DRP1 activation.
Xu LX, Wang RX, Jiang JF, Yi GC, Chang JJ, He RL, Jiao HX, Zheng B, Gui LX, Lin JJ, Huang ZH, Lin MJ, Wu ZJ
Toxicology and applied pharmacology 2023 Jul 1;470:116547
Toxicology and applied pharmacology 2023 Jul 1;470:116547
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
Liu WY, Li Y, Li Y, Xu LZ, Jia JP
Molecular neurobiology 2023 Jan;60(1):133-144
Molecular neurobiology 2023 Jan;60(1):133-144
Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.
Wang Q, Wang F, Li X, Ma Z, Jiang D
Phytotherapy research : PTR 2023 Jan;37(1):111-123
Phytotherapy research : PTR 2023 Jan;37(1):111-123
HIV Tat-Conjugated Histone H3 Peptides Induce Tumor Cell Death Via Cellular Stress Responses.
Xu Q, Zhu F, Pan Y, Ren Y, Li J, Huang N, Liu K, Wang Y
Human gene therapy 2023 Jan;34(1-2):42-55
Human gene therapy 2023 Jan;34(1-2):42-55
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Li M, Zhang Y, Han T, Guan L, Fan D, Wu Q, Liu J, Xu Y, Fan Y
Phytochemistry 2023 Jan;205:113487
Phytochemistry 2023 Jan;205:113487
Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation.
Shi M, Yang S, Huang X, Wang S, Li W, Yun J, Lu C, Yang Y, Cai C, Gao P, Guo X, Li B, Cao G
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13822
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13822
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.
Zheng HL, Sun SY, Jin T, Zhang M, Zeng Y, Liu Q, Yang K, Wei R, Pan Z, Lin F
Molecular pain 2023 Jan-Dec;19:17448069231152125
Molecular pain 2023 Jan-Dec;19:17448069231152125
Deficit of PKHD1L1 in the dentate gyrus increases seizure susceptibility in mice.
Yu J, Wang G, Chen Z, Wan L, Zhou J, Cai J, Liu X, Wang Y
Human molecular genetics 2023 Jan 13;32(3):506-519
Human molecular genetics 2023 Jan 13;32(3):506-519
Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis.
Yang N, Li M, Wu L, Song Y, Yu S, Wan Y, Cheng W, Yang B, Mou X, Yu H, Zheng J, Li X, Yu X
Journal of nanobiotechnology 2023 Jan 13;21(1):13
Journal of nanobiotechnology 2023 Jan 13;21(1):13
LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer.
Wu T, Li X, Yan G, Tan Z, Zhao D, Liu S, Wang H, Xiang Y, Chen W, Lu H, Liao X, Li Y, Lu Z
Journal of experimental & clinical cancer research : CR 2023 Jan 10;42(1):14
Journal of experimental & clinical cancer research : CR 2023 Jan 10;42(1):14
CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.
Xing F, Gao H, Chen G, Sun L, Sun J, Qiao X, Xue J, Liu C
Molecular cancer 2023 Jan 10;22(1):6
Molecular cancer 2023 Jan 10;22(1):6
Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.
Lin H, Li W, Shen Z, Bei Y, Wei T, Yu Z, Dai Y, Dai H
Neuroscience letters 2023 Jan 1;792:136941
Neuroscience letters 2023 Jan 1;792:136941
Elevated PGT promotes proliferation and inhibits cell apoptosis in preeclampsia by Erk signaling pathway.
Pang H, Lei D, Huang J, Guo Y, Fan C
Molecular and cellular probes 2023 Feb;67:101896
Molecular and cellular probes 2023 Feb;67:101896
Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma.
Zhu XF, Sun ZL, Ma J, Hu B, Yu MC, Liu XJ, Yang P, Xu Y, Ju D, Mu Q
Phytotherapy research : PTR 2023 Feb;37(2):592-610
Phytotherapy research : PTR 2023 Feb;37(2):592-610
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Teng L, Shen Y, Qu Y, Yang L, Yang Y, Jian X, Fan S, Zhang L, Fu Q
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity.
Liu XM, Li Z, Xie XR, Wang JQ, Qiao X, Qiao X, Xie CZ, Xu JY
Journal of medicinal chemistry 2023 Feb 9;66(3):1852-1872
Journal of medicinal chemistry 2023 Feb 9;66(3):1852-1872
Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia.
Guo Q, Fan Y, Wang Q, Li B, Qiu W, Qi Y, Pan Z, Zhang S, Zhao S, Yang K, Xu H, Li M, Gao Z, Xu J, Wang H, Wang S, Tang Q, Qiu J, Guo X, Deng L, Zhang P, Zhao R, Xue H, Wang C, Li G
Cell death & disease 2023 Feb 21;14(2):147
Cell death & disease 2023 Feb 21;14(2):147
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Wang Y, Liu Q, Chu C, Li L, Wang Z, Liu Q, Wu G, Wei X, An L, Ma J
Toxicology and applied pharmacology 2023 Feb 15;461:116385
Toxicology and applied pharmacology 2023 Feb 15;461:116385
Gelatin methacryloyl (GelMA) loaded with concentrated hypoxic pretreated adipose-derived mesenchymal stem cells(ADSCs) conditioned medium promotes wound healing and vascular regeneration in aged skin.
Li S, Sun J, Yang J, Yang Y, Ding H, Yu B, Ma K, Chen M
Biomaterials research 2023 Feb 13;27(1):11
Biomaterials research 2023 Feb 13;27(1):11
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Li Y, Zang J, Wang X, Feng X, Qiu F
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Wang Z, Li L, Chu C, Wei X, Liu Q, Wang R, Zhang G, Wu G, Wang Y, An L, Li X
International journal of oncology 2023 Dec;63(6)
International journal of oncology 2023 Dec;63(6)
Wen-Shen-Tong-Luo-Zhi-Tong Decoction regulates bone-fat balance in osteoporosis by adipocyte-derived exosomes.
Wang L, Pan Y, Liu M, Sun J, Yun L, Tu P, Wu C, Yu Z, Han Z, Li M, Guo Y, Ma Y
Pharmaceutical biology 2023 Dec;61(1):568-580
Pharmaceutical biology 2023 Dec;61(1):568-580
Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.
Yu B, Zhou M, Dong Z, Zheng H, Zhao Y, Zhou J, Zhang C, Wei F, Yu G, Liu WJ, Liu H, Wang Y
Pharmaceutical biology 2023 Dec;61(1):1222-1233
Pharmaceutical biology 2023 Dec;61(1):1222-1233
Mechanisms of dihydromyricetin against hepatocellular carcinoma elucidated by network pharmacology combined with experimental validation.
Zhang S, Shi YN, Gu J, He P, Ai QD, Zhou XD, Wang W, Qin L
Pharmaceutical biology 2023 Dec;61(1):1108-1119
Pharmaceutical biology 2023 Dec;61(1):1108-1119
Sema3A inactivates the ERK/JNK signalling pathways to alleviate inflammation and oxidative stress in lipopolysaccharide-stimulated rat endothelial cells and lung tissues.
Qiu Q, Yu X, Chen Q, He X
Autoimmunity 2023 Dec;56(1):2200908
Autoimmunity 2023 Dec;56(1):2200908
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Wang R, Li J, Fu Y, Li Y, Qi Y, Li C, Gao F, Li C
Biochemical pharmacology 2023 Dec;218:115874
Biochemical pharmacology 2023 Dec;218:115874
Herbal compound cepharanthine attenuates inflammatory arthritis by blocking macrophage M1 polarization.
Lu C, Cheng RJ, Zhang Q, Hu Y, Pu Y, Wen J, Zhong Y, Tang Z, Wu L, Wei S, Tsou PS, Fox DA, Li S, Luo Y, Liu Y
International immunopharmacology 2023 Dec;125(Pt B):111175
International immunopharmacology 2023 Dec;125(Pt B):111175
Liensinine improves AngII-induced vascular remodeling via MAPK/TGF-β1/Smad2/3 signaling.
Jia P, Chen D, Zhu Y, Wang M, Zeng J, Zhang L, Cai Q, Lian D, Zhao C, Xu Y, Chu J, Lin S, Peng J, Lin W
Journal of ethnopharmacology 2023 Dec 5;317:116768
Journal of ethnopharmacology 2023 Dec 5;317:116768
The ethanol extract of Scutellaria baicalensis Georgi attenuates complete Freund's adjuvant (CFA)-induced inflammatory pain by suppression of P2X3 receptor.
Gao L, Zhao JX, Qin XM, Zhao J
Journal of ethnopharmacology 2023 Dec 5;317:116762
Journal of ethnopharmacology 2023 Dec 5;317:116762
Modification of osimertinib to discover new potent EGFR(C797S)-TK inhibitors.
Xi XX, Zhao HY, Mao YZ, Xin M, Zhang SQ
European journal of medicinal chemistry 2023 Dec 5;261:115865
European journal of medicinal chemistry 2023 Dec 5;261:115865
Discovery of highly potent and selective KRAS(G12C) degraders by VHL-recruiting PROTACs for the treatment of tumors with KRAS(G12C)-Mutation.
Yang N, Fan Z, Sun S, Hu X, Mao Y, Jia C, Cai X, Xu T, Li B, Li Y, Han L, Wei T, Qian X, Qin W, Li P, Zheng Z, Li S
European journal of medicinal chemistry 2023 Dec 5;261:115857
European journal of medicinal chemistry 2023 Dec 5;261:115857
Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.
Guo Y, Tian J, Guo Y, Wang C, Chen C, Cai S, Yu W, Sun B, Yan J, Li Z, Fan J, Qi Q, Zhang D, Jin W, Hua Z, Chen G
Cell reports 2023 Dec 26;42(12):113511
Cell reports 2023 Dec 26;42(12):113511
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE(-/-) Mice.
Ren J, Liu J, Zhang J, Hu X, Cui Y, Wei X, Ma Y, Li X, Zhao Y
International journal of molecular sciences 2023 Dec 23;25(1)
International journal of molecular sciences 2023 Dec 23;25(1)
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation.
Yuan S, Che Y, Wang Z, Xing K, Xie X, Chen Y
Journal of translational medicine 2023 Dec 20;21(1):925
Journal of translational medicine 2023 Dec 20;21(1):925
GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.
Bao H, Peng Z, Cheng X, Jian C, Li X, Shi Y, Zhu W, Hu Y, Jiang M, Song J, Fang F, Chen J, Shu X
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344
Ultrasound-targeted microbubble destruction promotes PDGF-primed bone mesenchymal stem cell transplantation for myocardial protection in acute Myocardial Infarction in rats.
Sun Z, Cai Y, Chen Y, Jin Q, Zhang Z, Zhang L, Li Y, Huang L, Wang J, Yang Y, Lv Q, Han Z, Xie M, Zhu X
Journal of nanobiotechnology 2023 Dec 15;21(1):481
Journal of nanobiotechnology 2023 Dec 15;21(1):481
Banxia Xiexin decoction ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis via inhibiting serine-threonine protein kinase (Akt)/mitogen-activated protein kinase (MAPK) signaling pathway.
Ji W, Liu W, Huo Y, Hu C, Zhang Y
Biotechnology and applied biochemistry 2023 Aug;70(4):1530-1542
Biotechnology and applied biochemistry 2023 Aug;70(4):1530-1542
Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo.
Xiao Y, He Y, Xu C, Li M, Hu F, Wang W, Wang Z, Cao Y
Environmental toxicology 2023 Aug;38(8):1925-1938
Environmental toxicology 2023 Aug;38(8):1925-1938
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Wang X, Zhou Y, Sun Q, Zhang Q, Zhou H, Zhang J, Du Y, Wang Y, Yuan K, Xu L, Zhang M, Yan D, Zeng L, Xu K, Sang W
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
The Inhibitory Effect of RADKPS on Pyroptosis of Nucleus Pulposus-Derived Mesenchymal Stem Cells.
Zhu C, Zhou Q, Tang L, Xuan A, Xu C, Wang Z, Ruan D
Tissue engineering. Part A 2023 Aug;29(15-16):424-438
Tissue engineering. Part A 2023 Aug;29(15-16):424-438
ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy.
Mo W, Liu S, Zhao X, Wei F, Li Y, Sheng X, Cao W, Ding M, Zhang W, Chen X, Meng L, Yao S, Diao W, Wei H, Guo H
Advanced healthcare materials 2023 Aug;12(21):e2300191
Advanced healthcare materials 2023 Aug;12(21):e2300191
PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.
Cheng M, Cao H, Yao P, Guan J, Wu P, Ji H, Jiang S, Yuan Y, Fu L, Zheng Q, Li Q
Cell death & disease 2023 Aug 25;14(8):558
Cell death & disease 2023 Aug 25;14(8):558
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Li GH, Liu X, Feng LJ, Zhang L
Neoplasma 2023 Aug 20;
Neoplasma 2023 Aug 20;
The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer.
Li DM, Zhu FC, Wei J, Xie JX, He JH, Wei DM, Li Y, Lai KD, Liu LM, Su QB, Wei GN, Wang B, Liu YC
Journal of ethnopharmacology 2023 Aug 10;312:116454
Journal of ethnopharmacology 2023 Aug 10;312:116454
SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.
Huang H, Li X, Zha D, Lin H, Yang L, Wang Y, Xu L, Wang L, Lei T, Zhou Z, Xiao YF, Xin HB, Fu M, Qian Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Aug 1;101(4):303-312
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.
Shan F, Shen S, Wang X, Chen G
International journal of oncology 2023 Apr;62(4)
International journal of oncology 2023 Apr;62(4)
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling.
Wu C, Zhu G, Qiu F, Ren F, Lin B, Zhang D, Yang Q, Huang C
Virologica Sinica 2023 Apr;38(2):276-284
Virologica Sinica 2023 Apr;38(2):276-284
Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell.
Zhou W, Ma J, Zhao H, Wang Q, Guo X, Chen L, Cao Z, Xu J, Zhang B, Zhou X
Molecular & cellular proteomics : MCP 2023 Apr;22(4):100520
Molecular & cellular proteomics : MCP 2023 Apr;22(4):100520
Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling.
Wang H, Zhou HC, Ren RL, Du SX, Guo ZK, Shen XH
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Apr;22(2):179-189
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Apr;22(2):179-189
Exosomes incorporated with black phosphorus quantum dots attenuate retinal angiogenesis via disrupting glucose metabolism.
Gui X, Zhang H, Zhang R, Li Q, Zhu W, Nie Z, Zhao J, Cui X, Hao W, Wen X, Shen W, Song H
Materials today. Bio 2023 Apr;19:100602
Materials today. Bio 2023 Apr;19:100602
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Ma Y, Du Y, Yang J, He Q, Wang H, Lin X
Physiological research 2023 Apr 30;72(2):235-249
Physiological research 2023 Apr 30;72(2):235-249
The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
Zhang M, Yang K, Wang QH, Xie L, Liu Q, Wei R, Tao Y, Zheng HL, Lin N, Xu H, Yang L, Wang H, Zhang T, Xue Z, Cao JL, Pan Z
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 26;43(17):3009-3027
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 26;43(17):3009-3027
Promoted Skin Wound Healing by Tail-Amputated Eisenia foetida Proteins via the Ras/Raf/MEK/ERK Signaling Pathway.
Li T, Sun Y, Wang J, Zhang C, Sun Y
ACS omega 2023 Apr 18;8(15):13935-13943
ACS omega 2023 Apr 18;8(15):13935-13943
SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway.
Shang K, Ma N, Che J, Li H, Hu J, Sun H, Cao B
BMC cancer 2023 Apr 11;23(1):335
BMC cancer 2023 Apr 11;23(1):335
Subchronic Microcystin-LR Aggravates Colorectal Inflammatory Response and Barrier Disruption via Raf/ERK Signaling Pathway in Obese Mice.
Yang Y, Zheng S, Chu H, Du C, Chen M, Emran MY, Chen J, Yang F, Tian L
Toxins 2023 Apr 1;15(4)
Toxins 2023 Apr 1;15(4)
CMTM6 as a candidate risk gene for cervical cancer: Comprehensive bioinformatics study.
Huang X, Liu W, Liu C, Hu J, Wang B, Ren A, Huang X, Yuan Y, Liu J, Li M
Frontiers in molecular biosciences 2022;9:983410
Frontiers in molecular biosciences 2022;9:983410
7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells.
Fan Y, Li J, Huang L, Wang K, Zhao M
Ophthalmic research 2022;65(6):678-684
Ophthalmic research 2022;65(6):678-684
Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction.
Yuan Y, Wu H, Shuai B, Liu C, Zhu F, Gao F, Wei C, Fan H
Current pharmaceutical design 2022;28(42):3456-3468
Current pharmaceutical design 2022;28(42):3456-3468
Sufentanil Alleviates Sepsis-Induced Myocardial Injury and Stress Response in Rats through the ERK/GSK-3β Signaling Axis.
Zang H, Shao G, Lou Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9630716
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9630716
Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain.
Xi P, Mao R, Wu S, Liu L, Cai C, Lu L, Zhang C, Li Y
Mediators of inflammation 2022;2022:6010952
Mediators of inflammation 2022;2022:6010952
Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors.
Zhang M, Wang L, Liu W, Wang T, De Sanctis F, Zhu L, Zhang G, Cheng J, Cao Q, Zhou J, Tagliabue A, Bronte V, Yan D, Wan X, Yu G
Journal of immunology research 2022;2022:2253436
Journal of immunology research 2022;2022:2253436
Systematic Pharmacology-Based Strategy to Explore the Mechanism of Bufei Huoxue Capsule in the Treatment of Chronic Obstructive Pulmonary Disease.
Shi L, Yan J, Meng Y, Wang G, Du J, Feng C
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1129567
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1129567
Smart thermosensitive poloxamer hydrogels loaded with Nr-CWs for the treatment of diabetic wounds.
Wang J, Zhao B, Sun L, Jiang L, Li Q, Jin P
PloS one 2022;17(12):e0279727
PloS one 2022;17(12):e0279727
METTL3 Facilitates Tumor Progression by COL12A1/MAPK Signaling Pathway in Esophageal Squamous Cell Carcinoma.
Li J, Li Z, Xu Y, Huang C, Shan B
Journal of Cancer 2022;13(6):1972-1984
Journal of Cancer 2022;13(6):1972-1984
Bu-Gu-Sheng-Sui decoction promotes osteogenesis via activating the ERK/Smad signaling pathways.
Liu N, Qi B, Zhang Y, Fang S, Sun C, Li Q, Wei X
Frontiers in pharmacology 2022;13:976121
Frontiers in pharmacology 2022;13:976121
Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.
Qin X, Liu B, Gao F, Hu Y, Chen Z, Xu J, Zhang X
Frontiers in physiology 2022;13:856699
Frontiers in physiology 2022;13:856699
Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro.
He J, Xu D, Wang L, Yu X
Frontiers in pharmacology 2022;13:1079251
Frontiers in pharmacology 2022;13:1079251
Dysfunction of CCR1(+) decidual macrophages is a potential risk factor in the occurrence of unexplained recurrent pregnancy loss.
Sang Y, Li Y, Xu L, Chen J, Li D, Du M
Frontiers in immunology 2022;13:1045532
Frontiers in immunology 2022;13:1045532
High-Metastatic Melanoma Cells Promote the Metastatic Capability of Low-Metastatic Melanoma Cells via Exosomal Transfer of miR-411-5p.
Chen H, Zeng B, Li X, Zhao Q, Liu D, Chen Y, Zhang Y, Wang J, Xing HR
Frontiers in oncology 2022;12:895164
Frontiers in oncology 2022;12:895164
The Specifically Androgen-Regulated Gene (SARG) Promotes Papillary Thyroid Carcinoma (PTC) Lymphatic Metastasis Through Vascular Endothelial Growth Factor C (VEGF-C) and VEGF Receptor 3 (VEGFR-3) Axis.
Xu SJ, Jin B, Zhao WJ, Chen XX, Tong YY, Ding XF, Chen YY, Wang DH, Wang ZM, Dai BQ, Chen S, Liang Y, Chen G, Pan SJ, Xu LL
Frontiers in oncology 2022;12:817660
Frontiers in oncology 2022;12:817660
Poloxamer 407 and Hyaluronic Acid Thermosensitive Hydrogel-Encapsulated Ginsenoside Rg3 to Promote Skin Wound Healing.
Peng X, Ding C, Zhao Y, Hao M, Liu W, Yang M, Xiao F, Zheng Y
Frontiers in bioengineering and biotechnology 2022;10:831007
Frontiers in bioengineering and biotechnology 2022;10:831007
HIV-1 Tat Protein-Mediated Inflammatory Response Inhibits the Erythroid Hematopoietic Support Function of Bone Marrow Mesenchymal Stem Cells.
Wang X, Chen M, Ma S, Ding Y, Zhou C, Yuan Y
AIDS research and human retroviruses 2022 Sep;38(9):753-763
AIDS research and human retroviruses 2022 Sep;38(9):753-763
Interleukin 32 participates in cardiomyocyte-induced oxidative stress, inflammation and apoptosis during hypoxia/reoxygenation via the NOD2/NOX2/MAPK signaling pathway.
Li Y, Wang Z
Experimental and therapeutic medicine 2022 Sep;24(3):567
Experimental and therapeutic medicine 2022 Sep;24(3):567
Traditional herbal formula Jiao-tai-wan improves chronic restrain stress-induced depression-like behaviors in mice.
Tang Y, Wang H, Nie K, Gao Y, Su H, Wang Z, Lu F, Huang W, Dong H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113284
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113284
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Adediran S, Wang L, Khan MA, Guang W, Fan X, Dan H, Qi J, Jay SM, Carrier F, Hussain A
Cancers 2022 Sep 23;14(19)
Cancers 2022 Sep 23;14(19)
Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia.
Kang JB, Chen L, Leng XJ, Wang JJ, Cheng Y, Wu SH, Ma YY, Yang LJ, Cao YH, Yang X, Tong ZJ, Wu JZ, Wang YB, Zhou H, Liu JC, Ding N, Dai WC, Yu YC, Xue X, Sun SL, Dai XB, Chang L, Wang XL, Li NG, Shi ZH
Bioorganic & medicinal chemistry 2022 Sep 15;70:116937
Bioorganic & medicinal chemistry 2022 Sep 15;70:116937
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Xu Z, Sun X, Ding B, Zi M, Ma Y
Transplant immunology 2022 Oct;74:101664
Transplant immunology 2022 Oct;74:101664
Combination of RSK inhibitor LJH-685 and FLT3 inhibitor FF-10101 promoted apoptosis and proliferation inhibition of AML cell lines.
Zhang S, Liu J, Lu ZY, Xue YT, Mu XR, Liu Y, Cao J, Li ZY, Li F, Xu KL, Wu QY
Cellular oncology (Dordrecht, Netherlands) 2022 Oct;45(5):1005-1018
Cellular oncology (Dordrecht, Netherlands) 2022 Oct;45(5):1005-1018
Cpd-0225 attenuates renal fibrosis via inhibiting ALK5.
Xie SS, Dong ZH, He Y, Chen ZW, Yang Q, Ma WX, Li C, Chen Y, Wang JN, Yu JT, Xu CH, Ni WJ, Hou R, Suo XG, Wen JG, Jin J, Li J, Liu MM, Meng XM
Biochemical pharmacology 2022 Oct;204:115240
Biochemical pharmacology 2022 Oct;204:115240
Identification of four STAT3 isoforms and functional investigation of IL-6/JAK2/STAT3 pathway in blunt snout bream (Megalobrama amblycephala).
Wang J, Sun Q, Wu J, Tian W, Wang H, Liu H
Developmental and comparative immunology 2022 Oct;135:104484
Developmental and comparative immunology 2022 Oct;135:104484
Triclocarban evoked neutrophil extracellular trap formation in common carp (Cyprinus carpio L.) by modulating SIRT3-mediated ROS crosstalk with ERK1/2/p38 signaling.
Li S, Wang Y, Yu D, Zhang Y, Wang X, Shi M, Xiao Y, Li X, Xiao H, Chen L, Xiong X
Fish & shellfish immunology 2022 Oct;129:85-95
Fish & shellfish immunology 2022 Oct;129:85-95
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939
Bioorganic chemistry 2022 Oct;127:105939
Exosomal DNAJB11 promotes the development of pancreatic cancer by modulating the EGFR/MAPK pathway.
Liu P, Zu F, Chen H, Yin X, Tan X
Cellular & molecular biology letters 2022 Oct 8;27(1):87
Cellular & molecular biology letters 2022 Oct 8;27(1):87
ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8.
Cui X, Pei X, Wang H, Feng P, Qin H, Liu S, Yan Q, Liu J
Cells 2022 Oct 6;11(19)
Cells 2022 Oct 6;11(19)
Autophagy triggered by the ROS/ERK signaling pathway protects mouse embryonic palatal cells from apoptosis induced by nicotine.
Chen J, Yao Y, Wang Y, Wang X, Peng X, Li T, Liu Y, Du J
Environmental science and pollution research international 2022 Nov;29(54):81909-81922
Environmental science and pollution research international 2022 Nov;29(54):81909-81922
Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa.
Zhang X, Cao Y, Pan D, Yao X, Wang F, Zhang G, Luo Y
Phytochemistry 2022 Nov;203:113378
Phytochemistry 2022 Nov;203:113378
Non-Muscle MLCK Contributes to Endothelial Cell Hyper-Proliferation through the ERK Pathway as a Mechanism for Vascular Remodeling in Pulmonary Hypertension.
Anis M, Gonzales J, Halstrom R, Baig N, Humpal C, Demeritte R, Epshtein Y, Jacobson JR, Fraidenburg DR
International journal of molecular sciences 2022 Nov 7;23(21)
International journal of molecular sciences 2022 Nov 7;23(21)
Orally Administered Ginkgolide C Attenuates DSS-Induced Colitis by Maintaining Gut Barrier Integrity, Inhibiting Inflammatory Responses, and Regulating Intestinal Flora.
Xu D, Zhuang L, Gao S, Ma H, Cheng J, Liu J, Liu D, Fu S, Hu G
Journal of agricultural and food chemistry 2022 Nov 23;70(46):14718-14731
Journal of agricultural and food chemistry 2022 Nov 23;70(46):14718-14731
Effects of Camk2b Overexpression and Underexpression on the Proteome of Rat Hippocampal Neurons.
Yang C, Zhang M, Li S, Yi F, Huang H, Xie H, Liu H, Huang R, Zhou J
Neuroscience 2022 Nov 1;503:58-68
Neuroscience 2022 Nov 1;503:58-68
Effects of thymoquinone against angiotensin II‑induced cardiac damage in apolipoprotein E‑deficient mice.
Zhang L, Zhang H, Ma J, Wang Y, Pei Z, Ding H
International journal of molecular medicine 2022 May;49(5)
International journal of molecular medicine 2022 May;49(5)
Optimization of the saffron compound essence formula and its effect on preventing skin photoaging.
Li Q, Liu L, Jiang S, Xu Z, Lin S, Tong Y, Wang P
Journal of cosmetic dermatology 2022 Mar;21(3):1251-1262
Journal of cosmetic dermatology 2022 Mar;21(3):1251-1262
Immunomodulatory activity of aqueous extract from Crassostrea sikamea in the splenocytes of Sprague-Dawley rats.
Guo G, Kong Y, Su J, Wang G, Zhang M, Wang S, Song Z
Food science & nutrition 2022 Mar;10(3):813-821
Food science & nutrition 2022 Mar;10(3):813-821
Downregulation of lncRNA SNHG16 inhibits vascular smooth muscle cell proliferation and migration in cerebral atherosclerosis by targeting the miR-30c-5p/SDC2 axis.
Yang SN, Zhong LY, Sun YH, Wang C, Ru WJ, Liu RZ, Dai W, Xie XM, Li SD
Heart and vessels 2022 Jun;37(6):1085-1096
Heart and vessels 2022 Jun;37(6):1085-1096
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
Han X, Zhang J, Zhou L, Wei J, Tu Y, Shi Q, Zhang Y, Ren J, Wang Y, Ying H, Liang G
Phytotherapy research : PTR 2022 Jun;36(6):2511-2523
Phytotherapy research : PTR 2022 Jun;36(6):2511-2523
Blockade of mIL-6R alleviated lipopolysaccharide-induced systemic inflammatory response syndrome by suppressing NF-κB-mediated Ccl2 expression and inflammasome activation.
Dai JM, Zhang XQ, Zhang JJ, Yang WJ, Yang XM, Bian H, Chen ZN
MedComm 2022 Jun;3(2):e132
MedComm 2022 Jun;3(2):e132
A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells.
Wang L, Gao T, Li Y, Xie Y, Zeng S, Tai C, Feng Y, Shen P, Wang B
Stem cell research & therapy 2022 Jun 17;13(1):259
Stem cell research & therapy 2022 Jun 17;13(1):259
MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway.
Wang Y, Zhang J, Chu X, Wang M, Xin Y, Liu S
Lipids in health and disease 2022 Jun 15;21(1):54
Lipids in health and disease 2022 Jun 15;21(1):54
Near-Infrared Light-Responsive Nanoinhibitors for Tumor Suppression through Targeting and Regulating Anion Channels.
Li C, Shi S, Gao D, Li B, Song G, Chen Y, An H, Xing C
ACS applied materials & interfaces 2022 Jul 20;14(28):31715-31726
ACS applied materials & interfaces 2022 Jul 20;14(28):31715-31726
Effect of Qingyangshen glycosides on social defeat mice model.
Liu D, Wang J, Chang L, Zhu Q, Jiang N, Azhar M, Zeng G
Journal of ethnopharmacology 2022 Jul 15;293:115253
Journal of ethnopharmacology 2022 Jul 15;293:115253
Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway.
Su D, Liao L, Zeng Q, Liao Z, Liu Y, Jin C, Zhu G, Chen C, Yang M, Ai Z, Song Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153833
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153833
Investigation of cell cytotoxic activity and molecular mechanism of 5β,19-epoxycucurbita-6,23(E)-diene-3β,19(R),25-triol isolated from Momordica charantia on hepatoma cells.
Yuan MK, Kao JW, Wu WT, Chen CR, Chang CI, Wu YJ
Pharmaceutical biology 2022 Dec;60(1):1214-1223
Pharmaceutical biology 2022 Dec;60(1):1214-1223
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.
Li F, Mao Q, Wang J, Zhang X, Lv X, Wu B, Yan T, Jia Y
Metabolic brain disease 2022 Dec;37(8):2965-2978
Metabolic brain disease 2022 Dec;37(8):2965-2978
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites.
Zhang M, Zhang J, Wang C, Yan JK, Yi J, Ning J, Huo XK, Yu ZL, Zhang BJ, Sun CP, Ma XC
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15104-15115
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15104-15115
The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
Wu S, Liu H, Zhou M, Shang Y, Luo L, Chen J, Yang J
Journal of reproductive immunology 2022 Aug;152:103647
Journal of reproductive immunology 2022 Aug;152:103647
Downregulation of IL-8 and IL-10 by the Activation of Ca(2+)-Activated K(+) Channel K(Ca)3.1 in THP-1-Derived M(2) Macrophages.
Ohya S, Matsui M, Kajikuri J, Kito H, Endo K
International journal of molecular sciences 2022 Aug 3;23(15)
International journal of molecular sciences 2022 Aug 3;23(15)
Rhodococcus equi-Derived Extracellular Vesicles Promoting Inflammatory Response in Macrophage through TLR2-NF-κB/MAPK Pathways.
Xu Z, Hao X, Li M, Luo H
International journal of molecular sciences 2022 Aug 28;23(17)
International journal of molecular sciences 2022 Aug 28;23(17)
Systematic Survey of the Regulatory Networks of the Long Noncoding RNA BANCR in Cervical Cancer Cells.
Wang B, Wang M, Jia S, Li T, Yang M, Ge F
Journal of proteome research 2022 Apr 1;21(4):1137-1152
Journal of proteome research 2022 Apr 1;21(4):1137-1152
piR-121380 Is Involved in Cryo-Capacitation and Regulates Post-Thawed Boar Sperm Quality Through Phosphorylation of ERK2 via Targeting PTPN7.
Wang Y, Yuan X, Ali MA, Qin Z, Zhang Y, Zeng C
Frontiers in cell and developmental biology 2021;9:792994
Frontiers in cell and developmental biology 2021;9:792994
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Yang X, Jin J, Yang J, Zhou L, Mi S, Qi G
Genetics and molecular biology 2021;44(4):e20210058
Genetics and molecular biology 2021;44(4):e20210058
Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology.
Zhan L, Pu J, Hu Y, Xu P, Liang W, Ji C
BioMed research international 2021;2021:6621682
BioMed research international 2021;2021:6621682
Comparative Efficacy of Haizao Yuhu Decoction Composed of Different Varieties of Glycyrrhiza in Goiter Rats.
Chen F, Li N, Xiu L, Liu H, Chen S, He C, Fan A, Yu X, Wang X, Ge C, Huo M, He J, Zhong G
Evidence-based complementary and alternative medicine : eCAM 2021;2021:4343239
Evidence-based complementary and alternative medicine : eCAM 2021;2021:4343239
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
Drug design, development and therapy 2021;15:3207-3221
Drug design, development and therapy 2021;15:3207-3221
Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer.
Li H, Yang W, Zhang M, He T, Zhou F, G Herman J, Hu L, Guo M
Epigenomics 2021 Sep;13(17):1403-1419
Epigenomics 2021 Sep;13(17):1403-1419
Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway.
Jia Z, Yang J, Cao Z, Zhao J, Zhang J, Lu Y, Chu L, Zhang S, Chen Y, Pei L
Behavioural brain research 2021 Sep 24;414:113463
Behavioural brain research 2021 Sep 24;414:113463
Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine.
Zhang X, You L, Zhang X, Wang F, Wang Y, Zhou J, Liu C, Qu F
Chinese medicine 2021 Oct 2;16(1):97
Chinese medicine 2021 Oct 2;16(1):97
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.
Wu C, Huang ZH, Meng ZQ, Fan XT, Lu S, Tan YY, You LM, Huang JQ, Stalin A, Ye PZ, Wu ZS, Zhang JY, Liu XK, Zhou W, Zhang XM, Wu JR
Chinese medicine 2021 Nov 22;16(1):121
Chinese medicine 2021 Nov 22;16(1):121
1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways.
Tang JJ, Wang MR, Dong S, Huang LF, He QR, Gao JM
European journal of medicinal chemistry 2021 Nov 15;224:113713
European journal of medicinal chemistry 2021 Nov 15;224:113713
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.
Wang X, Gong Q, Song C, Fang J, Yang Y, Liang X, Huang X, Liu J
Toxicology and applied pharmacology 2021 May 1;418:115484
Toxicology and applied pharmacology 2021 May 1;418:115484
Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling.
Zhu K, Bai H, Mu M, Xue Y, Duan Z
FEBS open bio 2021 Jul;11(7):2041-2049
FEBS open bio 2021 Jul;11(7):2041-2049
Effects of Saccharides from Arctium lappa L. Root on FeCl(3)-Induced Arterial Thrombosis via the ERK/NF-κB Signaling Pathway.
Qiu T, Zhou H, Li S, Tian N, Li Z, Wang R, Sun P, Peng J, Du J, Ma X, Diao Y, Lv L, Wang L, Li H
Oxidative medicine and cellular longevity 2020;2020:7691352
Oxidative medicine and cellular longevity 2020;2020:7691352
MiR-1307-5p targeting TRAF3 upregulates the MAPK/NF-κB pathway and promotes lung adenocarcinoma proliferation.
Du X, Wang S, Liu X, He T, Lin X, Wu S, Wang D, Li J, Huang W, Yang H
Cancer cell international 2020;20:502
Cancer cell international 2020;20:502
Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression.
Jiang W, Li H, Liu X, Zhang J, Zhang W, Li T, Liu L, Yu X
Theranostics 2020;10(25):11507-11519
Theranostics 2020;10(25):11507-11519
Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.
Wang L, Zhan J, Huang W
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)
Resveratrol-loaded biopolymer core-shell nanoparticles: bioavailability and anti-inflammatory effects.
Liu Y, Liang X, Zou Y, Peng Y, McClements DJ, Hu K
Food & function 2020 May 1;11(5):4014-4025
Food & function 2020 May 1;11(5):4014-4025
Inhibiting PKCβ2 protects HK-2 cells against meglumine diatrizoate and AGEs-induced apoptosis and autophagy.
Jiang W, Zhao W, Ye F, Huang S, Wu Y, Chen H, Zhou R, Fu G
Annals of translational medicine 2020 Mar;8(6):293
Annals of translational medicine 2020 Mar;8(6):293
Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts.
Zhou D, Yang WK, Zhang YF, Xie JH, Ma L, Yang HD, Li Y, Xie P
Chinese journal of natural medicines 2020 Jun;18(6):436-445
Chinese journal of natural medicines 2020 Jun;18(6):436-445
Hfm1 participates in Golgi-associated spindle assembly and division in mouse oocyte meiosis.
Wang H, Zhong C, Yang R, Yin Y, Tan R, Gao L, Gao C, Cui Y, Pu D, Wu J
Cell death & disease 2020 Jun 30;11(6):490
Cell death & disease 2020 Jun 30;11(6):490
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Shopit A, Niu M, Wang H, Tang Z, Li X, Tesfaldet T, Ai J, Ahmad N, Al-Azab M, Tang Z
Life sciences 2020 Feb 1;242:117248
Life sciences 2020 Feb 1;242:117248
Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice.
Wang S, Chen Q, Zhang Y, Zheng F, Xue T, Ge X, Ma R, Li X, Wu R, Liang K, Qian Z, Ge Y, Ma J, Yao B
Reproductive toxicology (Elmsford, N.Y.) 2020 Dec;98:233-241
Reproductive toxicology (Elmsford, N.Y.) 2020 Dec;98:233-241
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Zhang Y, Sun J, Dong Y, Shen X, Zhang Z
Journal of biochemical and molecular toxicology 2020 Dec 16;:e22680
Journal of biochemical and molecular toxicology 2020 Dec 16;:e22680
MiR-96-5p promotes breast cancer migration by activating MEK/ERK signaling.
Qin WY, Feng SC, Sun YQ, Jiang GQ
The journal of gene medicine 2020 Aug;22(8):e3188
The journal of gene medicine 2020 Aug;22(8):e3188
PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation.
Lv JM, Chen L, Gao Y, Huang H, Pan XW, Liu X, Chen M, Qu FJ, Li L, Wang JK, Cui XG, Xu DF
OncoTargets and therapy 2018;11:5797-5809
OncoTargets and therapy 2018;11:5797-5809
Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling.
Wu Y, Wang M, Zhang K, Li Y, Xu M, Tang S, Qu X, Li C
Biochemical and biophysical research communications 2018 Sep 5;503(2):737-743
Biochemical and biophysical research communications 2018 Sep 5;503(2):737-743
Soluble epoxide hydrolase inhibition alleviated cognitive impairments via NRG1/ErbB4 signaling after chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis in mice.
Hao J, Chen Y, Yao E, Liu X
Brain research 2018 Nov 15;1699:89-99
Brain research 2018 Nov 15;1699:89-99
Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.
Zhao B, Liu L, Mao J, Liu K, Fan W, Liu J, Zhang Z, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1036-1044
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1036-1044
Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.
Liu GY, Shi JX, Shi SL, Liu F, Rui G, Li X, Gao LB, Deng XL, Li QF
Journal of cellular biochemistry 2017 Dec;118(12):4697-4707
Journal of cellular biochemistry 2017 Dec;118(12):4697-4707
Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.
Wang H, Cai J, Du S, Guo Z, Xin B, Wang J, Wei W, Shen X
Cell biochemistry and function 2017 Aug;35(6):315-326
Cell biochemistry and function 2017 Aug;35(6):315-326
HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth.
Lu Y, Wang Y, Zhang M, Liu L, Li F, Zhang J, Ye M, Zhao H, Zhao J, Yan B, Yang A, Zhang R, Li X, Ren X
Oncotarget 2016 Apr 26;7(17):23594-607
Oncotarget 2016 Apr 26;7(17):23594-607
SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway.
Li XL, Chen XQ, Zhang MN, Chen N, Nie L, Xu M, Gong J, Shen PF, Su ZZ, Weng X, Tan JY, Zhao T, Zeng H, Zhou Q
International journal of clinical and experimental pathology 2015;8(4):3871-81
International journal of clinical and experimental pathology 2015;8(4):3871-81
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y
International journal of clinical and experimental pathology 2015;8(12):15836-44
International journal of clinical and experimental pathology 2015;8(12):15836-44
Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca²⁺-dependent ERK signaling pathway.
Li X, Zhao H, Wang Q, Liang H, Jiang X
Molecular medicine reports 2015 May;11(5):3746-52
Molecular medicine reports 2015 May;11(5):3746-52
Polychlorinated biphenyl quinone induces endothelial barrier dysregulation by setting the cross talk between VE-cadherin, focal adhesion, and MAPK signaling.
Zhang P, Feng S, Bai H, Zeng P, Chen F, Wu C, Peng Y, Zhang Q, Zhang Q, Ye Q, Xue Q, Xu X, Song E, Song Y
American journal of physiology. Heart and circulatory physiology 2015 May 15;308(10):H1205-14
American journal of physiology. Heart and circulatory physiology 2015 May 15;308(10):H1205-14
Tenascin-C induces resistance to apoptosis in pancreatic cancer cell through activation of ERK/NF-κB pathway.
Shi M, He X, Wei W, Wang J, Zhang T, Shen X
Apoptosis : an international journal on programmed cell death 2015 Jun;20(6):843-57
Apoptosis : an international journal on programmed cell death 2015 Jun;20(6):843-57
Potential effect of matrix stiffness on the enrichment of tumor initiating cells under three-dimensional culture conditions.
Liu C, Liu Y, Xu XX, Wu H, Xie HG, Chen L, Lu T, Yang L, Guo X, Sun GW, Wang W, Ma XJ, He X
Experimental cell research 2015 Jan 1;330(1):123-34
Experimental cell research 2015 Jan 1;330(1):123-34
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A375 cells were subjected to SDS PAGE followed by western blot with 11257-1-AP(ERK1 antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 11257-1-AP(ERK1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ERK1/2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ERK1/2. This antibody recognizes human, mouse antigen. The ERK1/2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
