GABRA2

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Description

Gamma-aminobutyric acid type A receptor subunit alpha2

Tissue specificity

Tissue enhanced (brain, epididymis)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

4:p12 (46243548 - 46475230)

Ensembl ID

ENSG00000151834  (ver. 103.38)

Orthologs

Mouse Gabra2: ENSMUSG00000000560

UniProt

P47869

neXtProt

NX_P47869

Human splice variants
Mouse splice variants