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LearnHPA031763
antibody from Atlas Antibodies
Targeting: MCOLN1
ML4, MLIV, MST080, MSTP080, TRPM-L1, TRPML1
Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Immunocytochemistry [1]
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- Product number
- HPA031763 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA031763, RRID:AB_10600822
- Product name
- Anti-MCOLN1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human MCOLN1, Gene description: mucolipin 1, Alternative Gene Names: ML4, MLIV, MST080, MSTP080, TRPM-L1, TRPML1, Validated applications: ICC, WB, Uniprot ID: Q9GZU1, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system
Modulation of Lysosomal Cl− Mediates Migration and Apoptosis through the TRPML1 as a Lysosomal Cl− Sensor
Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis
Zhong D, Wang R, Zhang H, Wang M, Zhang X, Chen H
Nature Communications 2023;14(1)
Nature Communications 2023;14(1)
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system
Somogyi A, Kirkham E, Lloyd-Evans E, Winston J, Allen N, Mackrill J, Anderson K, Hawkins P, Gardiner S, Waller-Evans H, Sims R, Boland B, O'Neill C
Journal of Cell Science 2023;136(6)
Journal of Cell Science 2023;136(6)
Modulation of Lysosomal Cl− Mediates Migration and Apoptosis through the TRPML1 as a Lysosomal Cl− Sensor
Lee D, Hong J
Cells 2023;12(14):1835
Cells 2023;12(14):1835
Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis
Hui L, Soliman M, Geiger N, Miller N, Afghah Z, Lakpa K, Chen X, Geiger J
Journal of Alzheimer's Disease 2019;67(1):393-410
Journal of Alzheimer's Disease 2019;67(1):393-410
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
- Sample type
- Human
