66926-1-Ig

antibody from Proteintech Group

Targeting: GPNMB HGFIN, NMB

Provider product page for 66926-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [23]
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Product number: 66926-1-Ig - Provider product page
Provider: Proteintech Group
Product name: GPNMB antibody
Antibody type: Monoclonal
Description: GPNMB antibody (Cat. #66926-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2B10B8
Vial size: 20ul, 150ul

GPNMB protein structure - 66926-1-Ig shown in red.

Submitted references Glycoprotein non-metastatic melanoma protein B promotes pyroptosis of macrophages induced by homocysteine associated with the upregulation of the NOX-2/ NF-κB signaling pathway.

Zhang X, Tian T, Cao P, Ma X, Liu Y, Ding X, Yang X
Cellular signalling 2026 Jun;142:112429

APM⁺ macrophages associated with plaque vulnerability via MIF-CD74 signaling: a multi-omics study.

Xu X, Li Y, Xiang S, Liu X, Li R, Zheng B
Human genomics 2026 Jan 21;20(1):18

Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.

Duan R, Wang X, Wang Q, Zhou X, Gao S, Sun Y, Feng Q, Li Z, Yang Z, Ding J, Chen Z, Duan J, Yang Y
Cell reports 2026 Feb 24;45(2):116942

Lithium deficiency and the onset of Alzheimer's disease.

Aron L, Ngian ZK, Qiu C, Choi J, Liang M, Drake DM, Hamplova SE, Lacey EK, Roche P, Yuan M, Hazaveh SS, Lee EA, Bennett DA, Yankner BA
Nature 2025 Sep;645(8081):712-721

Lacticaseibacillus rhamnosus Probio-M9 Alters the Gut Microbiota and Mitigates Pulmonary Hypertension in a Rat Model.

Zhao Z, Li G, Ohmichi K, Li X, Zhao F, Ishikawa K, Ishikawa R, Nakamura K, Yokota N, Sun Z, Kurahara LH
Nutrients 2025 Sep 11;17(18)

In-situ-formed TCM-inspired dual-function nanocomposite hydrogel for intraoperative hemostasis and postoperative recurrence prevention in hepatocellular carcinoma.

Lu H, Li Y, Chen J, Song D, Luo X, Lu X, Huang X, Tan W, Xie C, Wang C
Materials today. Bio 2025 Oct;34:102192

Spatial-reprogramming derived GPNMB(+) macrophages interact with COL6A3(+) fibroblasts to enhance vascular fibrosis in glioblastoma.

Du Y, Long X, Li X, Guan F, Gao W, Deng K, Wang S, Lin X, Huang M, She X, Chen S, Wu M
Genome medicine 2025 Oct 31;17(1):136

Evaluation of nuclear pseudoinclusions, GATA3, 34βE12, and GPNMB performances in CK7 diffuse positive clear cell renal cell neoplasms.

Chen M, Liu Y, Wu Y, Xu H, Dong L, Zhou L, Yang X, Yang X
Human pathology 2025 Nov;165:105938

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease.

Aisenberg WH, O'Brien CA, Sangster M, Yaqoob F, Zhang Y, Temsamrit B, Thom S, Gosse L, Chaluvadi S, Elfayomi B, Lee G, Polam V, Levitt EM, Liu G, Lombroso SI, Nemec KM, Clowry G, Nieves C, Rawat P, Church E, Martinez D, Shoffler C, Kancheva D, Petucci C, Taylor D, Kofler J, Erskine D, Movahedi K, Bennett ML, Bennett FC
Immunity 2025 May 13;58(5):1254-1268.e9

Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression.

Liu Y, Pang L, Khan F, Wu J, Zhou F, Horbinski C, Bao S, Yu JS, Lathia JD, Chen P
JCI insight 2025 Jul 8;10(13)

Exploring Core Genes Involved in Ischemic Stroke and the Therapeutic Potential of Hyperbaric Oxygen: Insights from Transcriptomic Analysis.

Bao Y, Guo X, Wang J, Kang J, Ma R, Cheng X, Ma Y, Niu Y, Zhang W, Li X
Neuromolecular medicine 2025 Jul 26;27(1):54

Nanovaccine loaded with seno-antigen target senescent cells to improve metabolic disorders of adipose tissue and cardiac dysfunction.

Zhang K, Yin Q, Ma Y, Cao M, Li L, Jin X, Leng J
Human vaccines & immunotherapeutics 2025 Dec;21(1):2479229

The extracellular-matrix-remodeling capability exposes therapeutic vulnerability in a subset of renal cell carcinomas with tumor thrombi.

Zhang Q, Tan Y, Liang Q, Gu L, Shi Y, Huang Y, Li X, Qi J, Peng C, Wang H, Wang Y, Liu K, Cai T, He Y, Huang Q, Zhang X, Wang B, Ma X, Ci W
Developmental cell 2025 Dec 1;60(23):3201-3221.e15

GPNMB Expression Associates with Inferior Prognosis in Patients with Small Cell Lung Cancer.

Liu Q, Zhang J, Mao S, Zhang D, Dong Y, Hu P, Ren S
Journal of Cancer 2024;15(10):2960-2970

Single-cell RNA Sequencing Identifies a Novel Subtype of Microglia with High Cd74 Expression that Facilitates White Matter Inflammation During Chronic Cerebral Hypoperfusion.

Cheng W, Wang Y, Cheng C, Chen X, Zhang L, Huang W
Neurochemical research 2024 Oct;49(10):2821-2841

A TBK1-independent primordial function of STING in lysosomal biogenesis.

Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX
Molecular cell 2024 Oct 17;84(20):3979-3996.e9

A comprehensive evaluation of circ_0065214/ miR-188-3p/GPNMB axis in breast cancer.

Wu XX, Zhao YX, Xu SL, Wang LX, Mao JH, Wang B, Yang H
Cellular signalling 2024 Mar;115:111019

PCSK9 inhibitor protects against ischemic cerebral injury by attenuating inflammation via the GPNMB/CD44 pathway.

Zheng Y, Zhu T, Li G, Xu L, Zhang Y
International immunopharmacology 2024 Jan 5;126:111195

Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease.

Lee D, Vicari JM, Porras C, Spencer C, Pjanic M, Wang X, Kinrot S, Weiler P, Kosoy R, Bendl J, Prashant NM, Psychogyiou K, Malakates P, Hennigan E, Monteiro Fortes J, Zheng S, Therrien K, Mathur D, Kleopoulos SP, Shao Z, Argyriou S, Alvia M, Casey C, Hong A, Beaumont KG, Sebra R, Kellner CP, Bennett DA, Yuan GC, Voloudakis G, Theis FJ, Haroutunian V, Hoffman GE, Fullard JF, Roussos P
medRxiv : the preprint server for health sciences 2024 Dec 5;

The post-viral GPNMB(+) immune niche persists in long-term Covid, asthma, and COPD.

Wu K, Zhang Y, Yin-DeClue H, Sun K, Mao D, Crouch EC, Byers DE, Holtzman MJ
medRxiv : the preprint server for health sciences 2024 Aug 28;

Mining host candidate regulators of schistosomiasis-induced liver fibrosis in response to artesunate therapy through transcriptomics approach.

Yuan Y, Lv X, Wu Y, Weng Y, Dai F, Ding H, Chen R, Zheng B, Zhao W, Tong Q, Ding J, Lou D, Lai Y, Chu X, Zhao L, Lu S, Kong Q
PLoS neglected tropical diseases 2023 Sep;17(9):e0011626

Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma.

Lin Y, Qi Y, Jiang M, Huang W, Li B
International immunopharmacology 2023 Nov;124(Pt B):110972

TROP-2, Nectin-4, GPNMB, and B7-H3 Are Potentially Therapeutic Targets for Anaplastic Thyroid Carcinoma.

Toda S, Sato S, Saito N, Sekihara K, Matsui A, Murayama D, Nakayama H, Suganuma N, Okubo Y, Hayashi H, Iwasaki H, Miyagi Y, Hoshino D
Cancers 2022 Jan 24;14(3)

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