CABT-L1203
antibody from Creative Diagnostics
Targeting: ATG4B
APG4B, AUTL1, DKFZp586D1822, KIAA0943
Antibody data
- Antibody Data
- Antigen structure
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- Validations [0]
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- Product number
- CABT-L1203 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Rabbit Anti-Human ATG4B monoclonal antibody, clone 2ID7MD20
- Antibody type
- Monoclonal
- Description
- Cysteine protease ATG4b is an enzyme which is coded by ATG4b gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4b is a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4b, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4b is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2ID7MD20
- Concentration
- 0.5 mg/ml
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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