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- Antibody Data
- Antigen structure
- References [14]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 10969-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10969-2-AP, RRID:AB_2276346
- Product name
- CSN2 antibody
- Antibody type
- Polyclonal
- Description
- CSN2 antibody (Cat. #10969-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Insight into the mechanisms of milk protein synthesis via peptides derived from Micropterus salmoides.
EM Dipeptide Enhances Milk Protein Secretion: Evidence from Integrated Metabolomic and Transcriptomic Analysis.
Identification of O-GalNAc-modified proteins interacting with GALNT3 using proximity labeling method.
Crosslinking-mediated Interactome Analysis Identified PHD2-HIF1α Interaction Hotspots and the Role of PHD2 in Regulating Protein Neddylation.
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells.
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Glucose-induced CRL4(COP1)-p53 axis amplifies glycometabolism to drive tumorigenesis.
COP9 Signalosome Subunit 3 Restricts Neuroinflammatory Responses During Cerebral Ischemia/Reperfusion Injury Through Stabilizing Suppressor of Cytokine Signaling 3 Protein.
IP(6)-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.
Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.
RMP promotes epithelial-mesenchymal transition through NF-κB/CSN2/Snail pathway in hepatocellular carcinoma.
Kisspeptin-10 Induces β-Casein Synthesis via GPR54 and Its Downstream Signaling Pathways in Bovine Mammary Epithelial Cells.
Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.
Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death.
Liu B, Wu X, Zhang X, Hao G, Li X, Cai Y, Lv D, Li P, Yan Y, Zan L, Pan F
International journal of biological macromolecules 2025 Sep;322(Pt 4):147039
International journal of biological macromolecules 2025 Sep;322(Pt 4):147039
EM Dipeptide Enhances Milk Protein Secretion: Evidence from Integrated Metabolomic and Transcriptomic Analysis.
Liu Y, Yan Y, Yang R, Li X, Zhai C, Wu X, Fang X, Liu B
Metabolites 2025 Jul 14;15(7)
Metabolites 2025 Jul 14;15(7)
Identification of O-GalNAc-modified proteins interacting with GALNT3 using proximity labeling method.
Xu B, Zhang M, Yu Y, Yang M, Zhang Z, Wei M, Shan S, Zhu H, Su Y
Carbohydrate research 2025 Dec;558:109675
Carbohydrate research 2025 Dec;558:109675
Crosslinking-mediated Interactome Analysis Identified PHD2-HIF1α Interaction Hotspots and the Role of PHD2 in Regulating Protein Neddylation.
Ouyang H, How CY, Wang X, Yu C, Luo A, Huang L, Chen Y
bioRxiv : the preprint server for biology 2024 Dec 17;
bioRxiv : the preprint server for biology 2024 Dec 17;
Methionine Promotes Milk Protein Synthesis via the PI3K-mTOR Signaling Pathway in Human Mammary Epithelial Cells.
Li P, Fang X, Hao G, Li X, Cai Y, Yan Y, Zan L, Yang R, Liu B
Metabolites 2023 Nov 14;13(11)
Metabolites 2023 Nov 14;13(11)
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Hsu YH, Pintacuda G, Liu R, Nacu E, Kim A, Tsafou K, Petrossian N, Crotty W, Suh JM, Riseman J, Martin JM, Biagini JC, Mena D, Ching JKT, Malolepsza E, Li T, Singh T, Ge T, Egri SB, Tanenbaum B, Stanclift CR, Apffel AM, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Carr SA, Schenone M, Jaffe J, Fornelos N, Huang H, Eggan KC, Lage K
iScience 2023 May 19;26(5):106701
iScience 2023 May 19;26(5):106701
Glucose-induced CRL4(COP1)-p53 axis amplifies glycometabolism to drive tumorigenesis.
Su Y, Luo Y, Zhang P, Lin H, Pu W, Zhang H, Wang H, Hao Y, Xiao Y, Zhang X, Wei X, Nie S, Zhang K, Fu Q, Chen H, Huang N, Ren Y, Wu M, Chow BKC, Chen X, Jin W, Wang F, Zhao L, Rao F
Molecular cell 2023 Jul 6;83(13):2316-2331.e7
Molecular cell 2023 Jul 6;83(13):2316-2331.e7
COP9 Signalosome Subunit 3 Restricts Neuroinflammatory Responses During Cerebral Ischemia/Reperfusion Injury Through Stabilizing Suppressor of Cytokine Signaling 3 Protein.
Liang E, Li X, Fu W, Zhao C, Yang B, Yang Z
Neuropsychiatric disease and treatment 2021;17:1217-1227
Neuropsychiatric disease and treatment 2021;17:1217-1227
IP(6)-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.
Lin H, Yan Y, Luo Y, So WY, Wei X, Zhang X, Yang X, Zhang J, Su Y, Yang X, Zhang B, Zhang K, Jiang N, Chow BKC, Han W, Wang F, Rao F
Nature communications 2021 Apr 28;12(1):2461
Nature communications 2021 Apr 28;12(1):2461
Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.
Lin H, Zhang X, Liu L, Fu Q, Zang C, Ding Y, Su Y, Xu Z, He S, Yang X, Wei X, Mao H, Cui Y, Wei Y, Zhou C, Du L, Huang N, Zheng N, Wang T, Rao F
Proceedings of the National Academy of Sciences of the United States of America 2020 Feb 25;117(8):4117-4124
Proceedings of the National Academy of Sciences of the United States of America 2020 Feb 25;117(8):4117-4124
RMP promotes epithelial-mesenchymal transition through NF-κB/CSN2/Snail pathway in hepatocellular carcinoma.
Zhou W, Wang Q, Xu Y, Jiang J, Guo J, Yu H, Wei W
Oncotarget 2017 Jun 20;8(25):40373-40388
Oncotarget 2017 Jun 20;8(25):40373-40388
Kisspeptin-10 Induces β-Casein Synthesis via GPR54 and Its Downstream Signaling Pathways in Bovine Mammary Epithelial Cells.
Sun J, Liu J, Huang B, Kan X, Chen G, Wang W, Fu S
International journal of molecular sciences 2017 Dec 5;18(12)
International journal of molecular sciences 2017 Dec 5;18(12)
Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.
Scherer PC, Ding Y, Liu Z, Xu J, Mao H, Barrow JC, Wei N, Zheng N, Snyder SH, Rao F
Proceedings of the National Academy of Sciences of the United States of America 2016 Mar 29;113(13):3503-8
Proceedings of the National Academy of Sciences of the United States of America 2016 Mar 29;113(13):3503-8
Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death.
Rao F, Xu J, Khan AB, Gadalla MM, Cha JY, Xu R, Tyagi R, Dang Y, Chakraborty A, Snyder SH
Proceedings of the National Academy of Sciences of the United States of America 2014 Nov 11;111(45):16005-10
Proceedings of the National Academy of Sciences of the United States of America 2014 Nov 11;111(45):16005-10
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 10969-2-AP(COPS2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-COPS2 (IP:10969-2-AP, 3ug; Detection:10969-2-AP 1:500) with NIH/3T3 cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The COPS2/TRIP15 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human COPS2/TRIP15. This antibody recognizes human, mouse antigen. The COPS2/TRIP15 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
