Antibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11504-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11504-2-AP, RRID:AB_2066073
- Product name
- BubR1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BubR1 antibody (Cat. #11504-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SETDB2 interacts with BUBR1 to induce accurate chromosome segregation independently of its histone methyltransferase activity.
Exploring diverse programmed cell-death patterns to develop a novel gene signature for predicting the prognosis of lung adenocarcinoma patients.
Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven Neuroblastoma.
Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics.
Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.
CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
Cancer-Testis Gene Expression in Hepatocellular Carcinoma: Identification of Prognostic Markers and Potential Targets for Immunotherapy.
ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint.
KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells.
Protein phosphatase 4 plays dual roles during cell proliferation.
SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation.
Tu Y, Zhang H, Xia J, Zhao Y, Yang R, Feng J, Ma X, Li J
FEBS open bio 2024 Mar;14(3):444-454
FEBS open bio 2024 Mar;14(3):444-454
Exploring diverse programmed cell-death patterns to develop a novel gene signature for predicting the prognosis of lung adenocarcinoma patients.
Ma Z, Wang Y, Yu Y, Fu F, Zhang Y
Journal of thoracic disease 2024 Feb 29;16(2):911-923
Journal of thoracic disease 2024 Feb 29;16(2):911-923
Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven Neuroblastoma.
Zhai L, Balachandran A, Larkin R, Seneviratne JA, Chung SA, Lalwani A, Tsubota S, Beck D, Kadomatsu K, Beckers A, Durink K, De Preter K, Speleman F, Haber M, Norris MD, Swarbrick A, Cheung BB, Marshall GM, Carter DR
International journal of molecular sciences 2023 Oct 25;24(21)
International journal of molecular sciences 2023 Oct 25;24(21)
Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics.
Liu FJ, Chen XY, Yang J, Zhao Z, Wang QL, Li P, Jiang Y, Li HJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154635
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154635
Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.
Mengyan X, Kun D, Xinming J, Yutian W, Yongqian S
Frontiers in pharmacology 2022;13:997842
Frontiers in pharmacology 2022;13:997842
CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.
Zhou CJ, Wang XY, Dong YH, Wang DH, Han Z, Zhang XJ, Sun QY, Carroll J, Liang CG
Nature communications 2022 Dec 13;13(1):7732
Nature communications 2022 Dec 13;13(1):7732
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
Liang Y, Zhang M, Zhou P, Liu M, Li J, Wang Y
Bioorganic chemistry 2021 Oct;115:105239
Bioorganic chemistry 2021 Oct;115:105239
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
Xu W, Huang M, Guo J, Zhang H, Wang D, Liu T, Liu H, Chen S, Gao P, Mu K
International journal of biological sciences 2020;16(8):1388-1402
International journal of biological sciences 2020;16(8):1388-1402
Cancer-Testis Gene Expression in Hepatocellular Carcinoma: Identification of Prognostic Markers and Potential Targets for Immunotherapy.
Zhang YP, Bao ZW, Wu JB, Chen YH, Chen JR, Xie HY, Zhou L, Wu J, Zheng SS
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820944274
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820944274
ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint.
Yuan F, Jin X, Li D, Song Y, Zhang N, Yang X, Wang L, Zhu WG, Tian C, Zhao Y
Nucleic acids research 2019 Sep 5;47(15):8096-8110
Nucleic acids research 2019 Sep 5;47(15):8096-8110
KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.
Zhu ZC, Liu JW, Li K, Zheng J, Xiong ZQ
Oncogene 2018 May;37(22):2936-2952
Oncogene 2018 May;37(22):2936-2952
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
Zhou P, Liang Y, Zhang H, Jiang H, Feng K, Xu P, Wang J, Wang X, Ding K, Luo C, Liu M, Wang Y
European journal of medicinal chemistry 2018 Jan 20;144:817-842
European journal of medicinal chemistry 2018 Jan 20;144:817-842
Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells.
Wen C, Chen J, Zhang D, Wang H, Che J, Qin Q, He L, Cai Z, Lin M, Lou Q, Huang L, Chen D, Iwamoto A, Ren D, Wang L, Lan P, Wang J, Liu H, Yang X
Cancer letters 2016 Dec 28;383(2):295-308
Cancer letters 2016 Dec 28;383(2):295-308
Protein phosphatase 4 plays dual roles during cell proliferation.
Huang X, Liu J, Shen T, Meng X, Dou L, Lin Y, Li J
Cell proliferation 2016 Apr;49(2):219-35
Cell proliferation 2016 Apr;49(2):219-35
SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation.
Yuan YF, Zhai R, Liu XM, Khan HA, Zhen YH, Huo LJ
Molecular reproduction and development 2014 Aug;81(8):712-24
Molecular reproduction and development 2014 Aug;81(8):712-24
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 11504-2-AP(BUB1B antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BubR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BubR1. This antibody recognizes human, mouse antigen. The BubR1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.