330110

antibody from BioLegend

Targeting: CD209 CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

330110

Provider

BioLegend

Proper citation

BioLegend Cat#330110, RRID:AB_1236468

Product name

PerCP/Cy5.5 anti-human CD209 (DC-SIGN)

Antibody type

Monoclonal

Antigen

Extracellular domain of human DC-SIGN

Description

CD209, known as Dendritic Cell-Specific Intercellular adhesion molecule 3 (ICAM-3)-Grabbing Nonintegrin (DC-SIGN), is a 44 kD type II transmembrane glycoprotein and a member of the C-type lectin family. CD209 is expressed on myeloid dendritic cells, placental macrophages, liver and placental endothelial cells. CD209 binds to ICAM-3 (CD50), ICAM-2 (CD102), and Butyrophilin (BTN2A1), and mediates dendritic cell migration and T cell proliferation. Importantly, CD209 is a receptor of HIV-1 and some other viruses (such as West Nile virus, hepatitis C virus, etc), and some bacteria or parasites. It plays a criti­cal role in capturing and internalizing those pathogens. LSP1 (leukocyte-specific protein 1) interacts with the cytoplasmic domain of CD209 and mediates transport of HIV to the proteasome.

Reactivity

Human

Host

Mouse

Conjugate

Far-Red dye

Isotype

IgG

Vial size

100 tests

Storage

The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.