12-4900-42

antibody from Invitrogen Antibodies
Targeting: ITGA5 CD49e, FNRA
Provider product page for 12-4900-42

Antibody data

Product number
12-4900-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD49e (Integrin alpha 5) Monoclonal Antibody (P1D6), PE, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This P1D6 monoclonal antibody reacts with human CD49e, which is also known as integrin alpha 5. Integrins constitute a family of cell surface receptors that mediate adhesion between cells or between a cell and the extracellular matrix. These proteins are heterodimers consisting of two distinct subunits, alpha and beta. Integrin alpha 5 is expressed on thymocytes, T cells, monocytes, platelets, as well as early and activated B cells. Integrins are also expressed on non-hematopoietic and cancer cells. Integrin-mediated adhesion is regulated by changes in ligand affinity (or activation), cell shape, and integrin clustering and diffusion. Integrin alpha 5 undergoes post-translational cleavage in its extracellular domain to produce disulfide-linked light and heavy chains that associate with the common beta 1 subunit to form the fibronectin receptor. Studies have demonstrated the involvement of this integrin in cell adhesion, signaling, and apoptosis.
Conjugate
Yellow dye
Antibody clone number
P1D6
Concentration
5 µL/Test
ITGA5 protein structure - 12-4900-42 shown in red.