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- References [129]
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- Product number
- 25546-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#25546-1-AP, RRID:AB_2619655
- Product name
- cleaved-Caspase 3 antibody
- Antibody type
- Polyclonal
- Description
- cleaved-Caspase 3 antibody (Cat. #25546-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma.
Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway.
Simvastatin inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma through KLF2 signal.
Novel immunosuppressive effect of FK506 by upregulation of PD-L1 via FKBP51 in heart transplantation.
Excessive activation of IL-33/ST2 in cancer-associated fibroblasts promotes invasion and metastasis in ovarian cancer.
Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells.
Synergistic inhibition of the growth of MDA-MB-231 cells in triple-negative breast cancer by salinomycin combined with 17-AAG and its mechanism.
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.
Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation.
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs.
Downregulation of MiD49 contributes to tumor growth and metastasis of human pancreatic cancer.
Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway.
Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway.
NKAP plays an oncogenic function partly through AKT signaling pathway in hepatocellular carcinoma.
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
PES1 promotes BET inhibitors resistance and cells proliferation through increasing c-Myc expression in pancreatic cancer.
UNBS5162 inhibits SKOV3 ovarian cancer cell proliferation by regulating the PI3K/AKT signalling pathway.
Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Low doses of decitabine improve the chemotherapy efficacy against basal-like bladder cancer by targeting cancer stem cells.
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats.
An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
miR-30b suppresses the progression of breast cancer through inhibition of the PI3K/Akt signaling pathway by targeting Derlin-1.
TROAP regulates prostate cancer progression via the WNT3/survivin signalling pathways.
DART-seq: an antibody-free method for global m(6)A detection.
MicroRNA-2053 overexpression inhibits the development and progression of hepatocellular carcinoma.
SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway.
TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K/Akt/mTOR signaling pathway.
Protective effect and mechanism of rat recombinant S100 calcium-binding protein A4 on oxidative stress injury of rat vascular endothelial cells.
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA.
Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.
MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma.
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Dysfunction of DNA damage-inducible transcript 4 in the decidua is relevant to the pathogenesis of preeclampsia.
Tripterygium glycoside protects against puromycin amino nucleoside‑induced podocyte injury by upregulating autophagy.
Inhibition of Mitochondrial Fission Preserves Photoreceptors after Retinal Detachment.
UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway.
Role of piwi-interacting RNA-651 in the carcinogenesis of non-small cell lung cancer.
Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
Telmisartan inhibits NSCLC A549 cell proliferation and migration by regulating the PI3K/AKT signaling pathway.
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Volatile Oil from Amomi Fructus Attenuates 5-Fluorouracil-Induced Intestinal Mucositis.
Exogenous H2S Protects Against Diabetic Cardiomyopathy by Activating Autophagy via the AMPK/mTOR Pathway.
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation.
Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.
Sensitization of Radioresistant Prostate Cancer Cells by Resveratrol Isolated from Arachis hypogaea Stems.
Knockdown of tripartite motif-59 inhibits the malignant processes in human colorectal cancer cells.
Screening and identification of critical transcription factors involved in the protection of cardiomyocytes against hydrogen peroxide-induced damage by Yixin-shu.
Downregulated long non-coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells.
An integrated approach to identify critical transcription factors in the protection against hydrogen peroxide-induced oxidative stress by Danhong injection.
Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.
Losartan protects against cerebral ischemia/reperfusion-induced apoptosis through β-arrestin1-mediated phosphorylation of Akt.
Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells.
PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling.
PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination.
rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway.
7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation.
ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling.
miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer.
Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca(2+)-Dependent Antioxidant Response.
miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.
(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.
Bone marrow mesenchymal stem cells repair cadmium-induced rat testis injury by inhibiting mitochondrial apoptosis.
Down-regulation of UBC9 increases the sensitivity of hepatocellular carcinoma to doxorubicin.
PKCζ phosphorylates TRAF2 to protect against intestinal ischemia-reperfusion-induced injury.
Dalbinol, a rotenoid from Amorpha fruticosa L., exerts anti-proliferative activity by facilitating β-catenin degradation in hepatocellular carcinoma cells.
Far-infrared protects vascular endothelial cells from advanced glycation end products-induced injury via PLZF-mediated autophagy in diabetic mice.
Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium.
Downregulation of USP32 inhibits cell proliferation, migration and invasion in human small cell lung cancer.
Establishment of an ideal time window model in hypothermic-targeted temperature management after traumatic brain injury in rats.
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa.
Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes.
Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line.
Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling.
Sustained release of hepatocyte growth factor by cationic self-assembling peptide/heparin hybrid hydrogel improves β-cell survival and function through modulating inflammatory response.
Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.
Induction of Amnion Epithelial Apoptosis by Cortisol via tPA/Plasmin System.
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.
Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3H-indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis.
The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels.
Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.
Overexpression of myosin VI regulates gastric cancer cell progression.
17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway.
The effects of the 5-HT2A receptor antagonist sarpogrelate hydrochloride on chronic hypoxic pulmonary hypertension in rats.
piR-651 and its function in 95-D lung cancer cells.
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling.
Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death.
Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.
Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model.
Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.
miR-27a-mediated antiproliferative effects of metformin on the breast cancer cell line MCF-7.
Inhibition of Poly(ADP-Ribose) Polymerase-1 Protects Chronic Alcoholic Liver Injury.
Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Androgen-induced miR-135a acts as a tumor suppressor through downregulating RBAK and MMP11, and mediates resistance to androgen deprivation therapy.
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways.
Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells.
Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy.
Huaier Aqueous Extract Induces Hepatocellular Carcinoma Cells Arrest in S Phase via JNK Signaling Pathway.
Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway.
RhNRG-1β Protects the Myocardium against Irradiation-Induced Damage via the ErbB2-ERK-SIRT1 Signaling Pathway.
REV3L, a promising target in regulating the chemosensitivity of cervical cancer cells.
Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cells.
RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.
Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.
The role of visfatin on the regulation of inflammation and apoptosis in the spleen of LPS-treated rats.
Ginsenosides Rg1 from Panax ginseng: A Potential Therapy for Acute Liver Failure Patients?
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways.
Ishteyaque S, Singh G, Yadav KS, Verma S, Sharma RK, Sen S, Srivastava AK, Mitra K, Lahiri A, Bawankule DU, Rath SK, Kumar D, Mugale MN
Metabolism: clinical and experimental 2024 Mar;152:155771
Metabolism: clinical and experimental 2024 Mar;152:155771
Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway.
Hu W, Xie N, Pan M, Zhang Q, Zhang H, Wang F, Qu F
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117025
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117025
Simvastatin inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma through KLF2 signal.
Kou Y, Zhang Y, Rong X, Yang P, Wang C, Zhou Q, Liu H, Liu B, Li M
Journal of oral biosciences 2023 Dec;65(4):347-355
Journal of oral biosciences 2023 Dec;65(4):347-355
Novel immunosuppressive effect of FK506 by upregulation of PD-L1 via FKBP51 in heart transplantation.
Luo X, Du G, Chen B, Yan G, Zhu L, Cui P, Dai H, Qi Z, Lan T
Scandinavian journal of immunology 2022 Oct;96(4):e13203
Scandinavian journal of immunology 2022 Oct;96(4):e13203
Excessive activation of IL-33/ST2 in cancer-associated fibroblasts promotes invasion and metastasis in ovarian cancer.
Feng C, Kou L, Yin P, Jing Y
Oncology letters 2022 May;23(5):158
Oncology letters 2022 May;23(5):158
Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells.
Kalın ŞN, Altay A, Budak H
Chemico-biological interactions 2022 Jul 1;361:109984
Chemico-biological interactions 2022 Jul 1;361:109984
Synergistic inhibition of the growth of MDA-MB-231 cells in triple-negative breast cancer by salinomycin combined with 17-AAG and its mechanism.
He D, Wu B, Du J, Li L, Zhao J
Oncology letters 2022 Apr;23(4):138
Oncology letters 2022 Apr;23(4):138
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
Liu KL, Li XY, Wang DP, Xue WH, Qian XH, Li YH, Lin QQ, Li S, Meng FH
Journal of medicinal chemistry 2021 Sep 23;64(18):13356-13372
Journal of medicinal chemistry 2021 Sep 23;64(18):13356-13372
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Shopit A, Li X, Wang S, Awsh M, Safi M, Chu P, Jia J, Al-Radhi M, Baldi S, Wang F, Fang J, Peng J, Ma X, Tang Z, Shu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.
Zong B, Sun L, Peng Y, Wang Y, Yu Y, Lei J, Zhang Y, Guo S, Li K, Liu S
Oncology reports 2021 Jul;46(1)
Oncology reports 2021 Jul;46(1)
Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation.
Zheng T, Chen K, Zhang X, Feng H, Shi Y, Liu L, Zhang J, Chen Y
Aging 2020 Sep 8;12(18):18649-18659
Aging 2020 Sep 8;12(18):18649-18659
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs.
Li S, Li XY, Zhang TJ, Kamara MO, Liang JW, Zhu J, Meng FH
Bioorganic chemistry 2020 Jan;94:103385
Bioorganic chemistry 2020 Jan;94:103385
Downregulation of MiD49 contributes to tumor growth and metastasis of human pancreatic cancer.
Bai L, Liang J, Li L, Li E
Oncology reports 2020 Apr;43(4):1208-1220
Oncology reports 2020 Apr;43(4):1208-1220
Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway.
Guo S, Wang J, Xu H, Rong W, Gao C, Yuan Z, Xie F, Bi K, Zhang Z, Li Q
Oxidative medicine and cellular longevity 2019;2019:9096409
Oxidative medicine and cellular longevity 2019;2019:9096409
Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway.
Jia Y, Qi Y, Wang Y, Ma X, Xu Y, Wang J, Zhang X, Gao M, Cong B, Han S
Cancer cell international 2019;19:9
Cancer cell international 2019;19:9
NKAP plays an oncogenic function partly through AKT signaling pathway in hepatocellular carcinoma.
Song T, Liu JY, Yang JJ
Neoplasma 2019 Sep;66(5):792-800
Neoplasma 2019 Sep;66(5):792-800
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
Yue G, Chen C, Bai L, Wang G, Huang Y, Wang Y, Cui H, Xiao Y
Molecular medicine reports 2019 Nov;20(5):4551-4557
Molecular medicine reports 2019 Nov;20(5):4551-4557
PES1 promotes BET inhibitors resistance and cells proliferation through increasing c-Myc expression in pancreatic cancer.
Jin X, Fang R, Fan P, Zeng L, Zhang B, Lu X, Liu T
Journal of experimental & clinical cancer research : CR 2019 Nov 12;38(1):463
Journal of experimental & clinical cancer research : CR 2019 Nov 12;38(1):463
UNBS5162 inhibits SKOV3 ovarian cancer cell proliferation by regulating the PI3K/AKT signalling pathway.
Wang Q, Shi W
Oncology letters 2019 Mar;17(3):2976-2982
Oncology letters 2019 Mar;17(3):2976-2982
Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Lu GQ, Li XY, Mohamed O K, Wang D, Meng FH
European journal of medicinal chemistry 2019 Jun 1;171:282-296
European journal of medicinal chemistry 2019 Jun 1;171:282-296
Low doses of decitabine improve the chemotherapy efficacy against basal-like bladder cancer by targeting cancer stem cells.
Wu M, Sheng L, Cheng M, Zhang H, Jiang Y, Lin S, Liang Y, Zhu F, Liu Z, Zhang Y, Zhang X, Gao Q, Chen D, Li J, Li Y
Oncogene 2019 Jul;38(27):5425-5439
Oncogene 2019 Jul;38(27):5425-5439
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
Li XY, Zhang TJ, Kamara MO, Lu GQ, Xu HL, Wang DP, Meng FH
Cell death & disease 2019 Jul 11;10(7):532
Cell death & disease 2019 Jul 11;10(7):532
Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats.
Uslusoy F, Nazıroğlu M, Övey İS, Sönmez TT
The Journal of pharmacy and pharmacology 2019 Jan;71(1):83-92
The Journal of pharmacy and pharmacology 2019 Jan;71(1):83-92
An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.
Ehrmann I, Crichton JH, Gazzara MR, James K, Liu Y, Grellscheid SN, Curk T, de Rooij D, Steyn JS, Cockell S, Adams IR, Barash Y, Elliott DJ
eLife 2019 Jan 24;8
eLife 2019 Jan 24;8
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
Liu C, Wang X, Zhang Y
Technology in cancer research & treatment 2019 Jan 1;18:1533033819871306
Technology in cancer research & treatment 2019 Jan 1;18:1533033819871306
miR-30b suppresses the progression of breast cancer through inhibition of the PI3K/Akt signaling pathway by targeting Derlin-1.
Zhou J, Xiang AZ, Guo JF, Cui HD
Translational cancer research 2019 Feb;8(1):180-190
Translational cancer research 2019 Feb;8(1):180-190
TROAP regulates prostate cancer progression via the WNT3/survivin signalling pathways.
Ye J, Chu C, Chen M, Shi Z, Gan S, Qu F, Pan X, Yang Q, Tian Y, Wang L, Yang W, Cui X
Oncology reports 2019 Feb;41(2):1169-1179
Oncology reports 2019 Feb;41(2):1169-1179
DART-seq: an antibody-free method for global m(6)A detection.
Meyer KD
Nature methods 2019 Dec;16(12):1275-1280
Nature methods 2019 Dec;16(12):1275-1280
MicroRNA-2053 overexpression inhibits the development and progression of hepatocellular carcinoma.
Song T, Ma K, Zhao C, Yang J, Liu J
Oncology letters 2019 Aug;18(2):2043-2049
Oncology letters 2019 Aug;18(2):2043-2049
SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway.
Xu H, Xu S, Zhang R, Xin T, Pang Q
OncoTargets and therapy 2018;11:3775-3783
OncoTargets and therapy 2018;11:3775-3783
TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K/Akt/mTOR signaling pathway.
Li L, Qi Y, Ma X, Xiong G, Wang L, Bao C
Cell biology international 2018 Sep;42(9):1192-1199
Cell biology international 2018 Sep;42(9):1192-1199
Protective effect and mechanism of rat recombinant S100 calcium-binding protein A4 on oxidative stress injury of rat vascular endothelial cells.
Meng X, Gao X, Zhang Z, Zhou X, Wu L, Yang M, Wang K, Ren H, Sun B, Wang T
Oncology letters 2018 Sep;16(3):3614-3622
Oncology letters 2018 Sep;16(3):3614-3622
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Batool S, Joseph TP, Hussain M, Vuai MS, Khinsar KH, Din SRU, Padhiar AA, Zhong M, Ning A, Zhang W, Cao J, Huang M
International journal of molecular sciences 2018 Sep 30;19(10)
International journal of molecular sciences 2018 Sep 30;19(10)
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
Yu G, Liao J, Wu J, Ding J, Zhang L
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701
DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA.
Shi Y, Guo X, Zhang J, Zhou H, Sun B, Feng J
Brain, behavior, and immunity 2018 Oct;73:482-492
Brain, behavior, and immunity 2018 Oct;73:482-492
Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.
Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, Geng S, Wu J, Zhong C, Li M
Journal of cellular biochemistry 2018 May;119(5):4134-4141
Journal of cellular biochemistry 2018 May;119(5):4134-4141
MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma.
Wu T, Lin Y, Xie Z
Biological research 2018 May 24;51(1):13
Biological research 2018 May 24;51(1):13
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
Liu S, Liu B
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 9;24:1424-1433
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 9;24:1424-1433
Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Li XY, Liang JW, Mohamed O K, Zhang TJ, Lu GQ, Meng FH
European journal of medicinal chemistry 2018 Jun 25;154:267-279
European journal of medicinal chemistry 2018 Jun 25;154:267-279
Dysfunction of DNA damage-inducible transcript 4 in the decidua is relevant to the pathogenesis of preeclampsia.
Yang J, Zhang Y, Tong J, Lv H, Zhang C, Chen ZJ
Biology of reproduction 2018 Jun 1;98(6):821-833
Biology of reproduction 2018 Jun 1;98(6):821-833
Tripterygium glycoside protects against puromycin amino nucleoside‑induced podocyte injury by upregulating autophagy.
Gong J, Jin J, Zhao L, Li Y, Li Y, He Q
International journal of molecular medicine 2018 Jul;42(1):115-122
International journal of molecular medicine 2018 Jul;42(1):115-122
Inhibition of Mitochondrial Fission Preserves Photoreceptors after Retinal Detachment.
She X, Lu X, Li T, Sun J, Liang J, Zhai Y, Yang S, Gu Q, Wei F, Zhu H, Wang F, Luo X, Sun X
The American journal of pathology 2018 Jul;188(7):1713-1722
The American journal of pathology 2018 Jul;188(7):1713-1722
UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway.
He D, Zhang S
Molecular medicine reports 2018 Jan;17(1):549-555
Molecular medicine reports 2018 Jan;17(1):549-555
Role of piwi-interacting RNA-651 in the carcinogenesis of non-small cell lung cancer.
Zhang SJ, Yao J, Shen BZ, Li GB, Kong SS, Bi DD, Pan SH, Cheng BL
Oncology letters 2018 Jan;15(1):940-946
Oncology letters 2018 Jan;15(1):940-946
Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
Meng M, Chen Y, Jia J, Li L, Yang S
Biological research 2018 Aug 10;51(1):24
Biological research 2018 Aug 10;51(1):24
Telmisartan inhibits NSCLC A549 cell proliferation and migration by regulating the PI3K/AKT signaling pathway.
Zhang S, Wang Y
Oncology letters 2018 Apr;15(4):5859-5864
Oncology letters 2018 Apr;15(4):5859-5864
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Ren T, Wang J, Zhang H, Yuan P, Zhu J, Wu Y, Huang Q, Guo X, Zhang J, Ji L, Li J, Zhang H, Yang H, Xing J
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Volatile Oil from Amomi Fructus Attenuates 5-Fluorouracil-Induced Intestinal Mucositis.
Zhang T, Lu SH, Bi Q, Liang L, Wang YF, Yang XX, Gu W, Yu J
Frontiers in pharmacology 2017;8:786
Frontiers in pharmacology 2017;8:786
Exogenous H2S Protects Against Diabetic Cardiomyopathy by Activating Autophagy via the AMPK/mTOR Pathway.
Yang F, Zhang L, Gao Z, Sun X, Yu M, Dong S, Wu J, Zhao Y, Xu C, Zhang W, Lu F
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1168-1187
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1168-1187
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Jiang Z, Song F, Li Y, Xue D, Zhao N, Zhang J, Deng G, Li M, Liu X, Wang Y
Oxidative medicine and cellular longevity 2017;2017:6175841
Oxidative medicine and cellular longevity 2017;2017:6175841
Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation.
Deng F, Wang S, Cai S, Hu Z, Xu R, Wang J, Feng D, Zhang L
Oxidative medicine and cellular longevity 2017;2017:3542149
Oxidative medicine and cellular longevity 2017;2017:3542149
Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.
Min M, Yan BX, Wang P, Landeck L, Chen JQ, Li W, Cai SQ, Zheng M, Man XY
PloS one 2017;12(12):e0190051
PloS one 2017;12(12):e0190051
Sensitization of Radioresistant Prostate Cancer Cells by Resveratrol Isolated from Arachis hypogaea Stems.
Chen YA, Lien HM, Kao MC, Lo UG, Lin LC, Lin CJ, Chang SJ, Chen CC, Hsieh JT, Lin H, Tang CH, Lai CH
PloS one 2017;12(1):e0169204
PloS one 2017;12(1):e0169204
Knockdown of tripartite motif-59 inhibits the malignant processes in human colorectal cancer cells.
Wu W, Chen J, Wu J, Lin J, Yang S, Yu H
Oncology reports 2017 Oct;38(4):2480-2488
Oncology reports 2017 Oct;38(4):2480-2488
Screening and identification of critical transcription factors involved in the protection of cardiomyocytes against hydrogen peroxide-induced damage by Yixin-shu.
Zhang J, Geng Y, Guo F, Zhang F, Liu M, Song L, Ma Y, Li D, Zhang Y, Xu H, Yang H
Scientific reports 2017 Oct 24;7(1):13867
Scientific reports 2017 Oct 24;7(1):13867
Downregulated long non-coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells.
Zhao Z, Xue J, Song Y, Liu T, Piao D
Oncology letters 2017 Nov;14(5):6143-6150
Oncology letters 2017 Nov;14(5):6143-6150
An integrated approach to identify critical transcription factors in the protection against hydrogen peroxide-induced oxidative stress by Danhong injection.
Zhang J, Guo F, Wei J, Xian M, Tang S, Zhao Y, Liu M, Song L, Geng Y, Yang H, Ding C, Huang L
Free radical biology & medicine 2017 Nov;112:480-493
Free radical biology & medicine 2017 Nov;112:480-493
Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.
Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, Yu D, Zhong C
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527
Losartan protects against cerebral ischemia/reperfusion-induced apoptosis through β-arrestin1-mediated phosphorylation of Akt.
Chen L, Ren Z, Wei X, Wang S, Wang Y, Cheng Y, Gao H, Liu H
European journal of pharmacology 2017 Nov 15;815:98-108
European journal of pharmacology 2017 Nov 15;815:98-108
Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells.
Huang Z, Yang G, Shen T, Wang X, Li H, Ren D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 May;89:623-631
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 May;89:623-631
PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling.
Yang W, Yang LF, Song ZQ, Shah SZA, Cui YY, Li CS, Zhao HF, Gao HL, Zhou XM, Zhao DM
CNS neuroscience & therapeutics 2017 May;23(5):416-427
CNS neuroscience & therapeutics 2017 May;23(5):416-427
PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Xu X, Cui Y, Cao L, Zhang Y, Yin Y, Hu X
Experimental and therapeutic medicine 2017 May;13(5):1993-1999
Experimental and therapeutic medicine 2017 May;13(5):1993-1999
TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination.
Zhang J, Zhang C, Cui J, Ou J, Han J, Qin Y, Zhi F, Wang RF
Cell death & disease 2017 May 25;8(5):e2831
Cell death & disease 2017 May 25;8(5):e2831
rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway.
Jiang Q, Li Q, Han J, Gou M, Zheng Y, Li B, Xiao R, Wang J
International journal of biological macromolecules 2017 Mar;96:652-668
International journal of biological macromolecules 2017 Mar;96:652-668
7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation.
Zhu Y, Jiang Y, Shi L, Du L, Xu X, Wang E, Sun Y, Guo X, Zou B, Wang H, Wang C, Sun L, Zhen Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Mar;87:527-538
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Mar;87:527-538
ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling.
Yang W, Yang S, Zhang M, Gao D, He T, Guo M
Genes & cancer 2017 Mar;8(3-4):528-535
Genes & cancer 2017 Mar;8(3-4):528-535
miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer.
Sun R, Liu Z, Tong D, Yang Y, Guo B, Wang X, Zhao L, Huang C
Cell death & disease 2017 Mar 30;8(3):e2714
Cell death & disease 2017 Mar 30;8(3):e2714
Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.
Wu D, Luo N, Wang L, Zhao Z, Bu H, Xu G, Yan Y, Che X, Jiao Z, Zhao T, Chen J, Ji A, Li Y, Lee GD
Scientific reports 2017 Mar 28;7(1):455
Scientific reports 2017 Mar 28;7(1):455
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
Yang F, Yu X, Li T, Wu J, Zhao Y, Liu J, Sun A, Dong S, Wu J, Zhong X, Xu C, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca(2+)-Dependent Antioxidant Response.
Ji L, Liu F, Jing Z, Huang Q, Zhao Y, Cao H, Li J, Yin C, Xing J, Li F
Diabetes 2017 Jun;66(6):1586-1600
Diabetes 2017 Jun;66(6):1586-1600
miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.
Zhu J, Wang S, Chen Y, Li X, Jiang Y, Yang X, Li Y, Wang X, Meng Y, Zhu M, Ma X, Huang C, Wu R, Xie C, Geng S, Wu J, Zhong C, Han H
The Journal of nutritional biochemistry 2017 Jun;44:80-91
The Journal of nutritional biochemistry 2017 Jun;44:80-91
(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.
Chen Y, Wang XQ, Zhang Q, Zhu JY, Li Y, Xie CF, Li XT, Wu JS, Geng SS, Zhong CY, Han HY
Nutrients 2017 Jun 3;9(6)
Nutrients 2017 Jun 3;9(6)
Bone marrow mesenchymal stem cells repair cadmium-induced rat testis injury by inhibiting mitochondrial apoptosis.
Wang YJ, Yan J, Zou XL, Guo KJ, Zhao Y, Meng CY, Yin F, Guo L
Chemico-biological interactions 2017 Jun 1;271:39-47
Chemico-biological interactions 2017 Jun 1;271:39-47
Down-regulation of UBC9 increases the sensitivity of hepatocellular carcinoma to doxorubicin.
Fang S, Qiu J, Wu Z, Bai T, Guo W
Oncotarget 2017 Jul 25;8(30):49783-49795
Oncotarget 2017 Jul 25;8(30):49783-49795
PKCζ phosphorylates TRAF2 to protect against intestinal ischemia-reperfusion-induced injury.
Zhou W, Yao J, Wang G, Chen Z, Li Z, Feng D, Li Y, Qasim W, Tan W, Ning S, Tian X
Cell death & disease 2017 Jul 20;8(7):e2935
Cell death & disease 2017 Jul 20;8(7):e2935
Dalbinol, a rotenoid from Amorpha fruticosa L., exerts anti-proliferative activity by facilitating β-catenin degradation in hepatocellular carcinoma cells.
Zhu X, Wu X, Cheng J, Liao H, Di X, Li L, Li R, Zhou Y, Zhang X
Oncotarget 2017 Jul 18;8(29):47755-47766
Oncotarget 2017 Jul 18;8(29):47755-47766
Far-infrared protects vascular endothelial cells from advanced glycation end products-induced injury via PLZF-mediated autophagy in diabetic mice.
Chen CH, Chen TH, Wu MY, Chou TC, Chen JR, Wei MJ, Lee SL, Hong LY, Zheng CM, Chiu IJ, Lin YF, Hsu CM, Hsu YH
Scientific reports 2017 Jan 10;7:40442
Scientific reports 2017 Jan 10;7:40442
Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.
Zhu J, Jiang Y, Yang X, Wang S, Xie C, Li X, Li Y, Chen Y, Wang X, Meng Y, Zhu M, Wu R, Huang C, Ma X, Geng S, Wu J, Zhong C
Biochemical and biophysical research communications 2017 Jan 1;482(1):15-21
Biochemical and biophysical research communications 2017 Jan 1;482(1):15-21
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Huang T, Xiao Y, Yi L, Li L, Wang M, Tian C, Ma H, He K, Wang Y, Han B, Ye X, Li X
Scientific reports 2017 Feb 6;7:38524
Scientific reports 2017 Feb 6;7:38524
Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium.
Yüksel E, Nazıroğlu M, Şahin M, Çiğ B
Scientific reports 2017 Dec 13;7(1):17543
Scientific reports 2017 Dec 13;7(1):17543
Downregulation of USP32 inhibits cell proliferation, migration and invasion in human small cell lung cancer.
Hu W, Wei H, Li K, Li P, Lin J, Feng R
Cell proliferation 2017 Aug;50(4)
Cell proliferation 2017 Aug;50(4)
Establishment of an ideal time window model in hypothermic-targeted temperature management after traumatic brain injury in rats.
Zhao WY, Chen SB, Wang JJ, Xu C, Zhao ML, Dong HJ, Liang HQ, Li XH, Tu Y, Zhang S, Chen C, Sun HT
Brain research 2017 Aug 15;1669:141-149
Brain research 2017 Aug 15;1669:141-149
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Wu J, Tian Z, Sun Y, Lu C, Liu N, Gao Z, Zhang L, Dong S, Yang F, Zhong X, Xu C, Lu F, Zhang W
Cell death & disease 2017 Aug 10;8(8):e2992
Cell death & disease 2017 Aug 10;8(8):e2992
Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.
Zhu JY, Yang X, Chen Y, Jiang Y, Wang SJ, Li Y, Wang XQ, Meng Y, Zhu MM, Ma X, Huang C, Wu R, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2017 Apr;31(4):680-688
Phytotherapy research : PTR 2017 Apr;31(4):680-688
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
Shah SZA, Zhao D, Taglialatela G, Khan SH, Hussain T, Dong H, Lai M, Zhou X, Yang L
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):463-483
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):463-483
Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa.
Ma H, Li L, Dou G, Wang C, Li J, He H, Wu M, Qi H
Oncotarget 2017 Apr 25;8(17):29328-29345
Oncotarget 2017 Apr 25;8(17):29328-29345
Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.
Gan Z, Han K, Lin S, Hu H, Shen Z, Min D
Biological research 2017 Apr 12;50(1):15
Biological research 2017 Apr 12;50(1):15
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, Dong S, Yang F, Zhang L, Zhong X, Xu C, Lu F, Zhang W
Cell & bioscience 2016;6:33
Cell & bioscience 2016;6:33
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes.
Li L, Li M, Li Y, Sun W, Wang Y, Bai S, Li H, Wu B, Yang G, Wang R, Wu L, Li H, Xu C
Cell & bioscience 2016;6:26
Cell & bioscience 2016;6:26
Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line.
Cui Y, Zhao D, Sreevatsan S, Liu C, Yang W, Song Z, Yang L, Barrow P, Zhou X
Frontiers in cellular and infection microbiology 2016;6:182
Frontiers in cellular and infection microbiology 2016;6:182
Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling.
Zhang C, Li L, Zhao B, Jiao A, Li X, Sun N, Zhang J
International journal of endocrinology 2016;2016:4513051
International journal of endocrinology 2016;2016:4513051
Sustained release of hepatocyte growth factor by cationic self-assembling peptide/heparin hybrid hydrogel improves β-cell survival and function through modulating inflammatory response.
Liu S, Zhang L, Cheng J, Lu Y, Liu J
International journal of nanomedicine 2016;11:4875-4890
International journal of nanomedicine 2016;11:4875-4890
Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.
Dai C, Tang S, Velkov T, Xiao X
Molecular neurobiology 2016 Sep;53(7):4685-700
Molecular neurobiology 2016 Sep;53(7):4685-700
Induction of Amnion Epithelial Apoptosis by Cortisol via tPA/Plasmin System.
Wang W, Liu C, Sun K
Endocrinology 2016 Nov;157(11):4487-4498
Endocrinology 2016 Nov;157(11):4487-4498
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.
Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C, Wang Q, Tang TS
PLoS biology 2016 Nov;14(11):e2000733
PLoS biology 2016 Nov;14(11):e2000733
Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3H-indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis.
Song Z, Chen CP, Liu J, Wen X, Sun H, Yuan H
European journal of medicinal chemistry 2016 Nov 29;124:809-819
European journal of medicinal chemistry 2016 Nov 29;124:809-819
The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels.
Akpınar H, Nazıroğlu M, Övey İS, Çiğ B, Akpınar O
Scientific reports 2016 Nov 22;6:37196
Scientific reports 2016 Nov 22;6:37196
Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.
Shi WY, Cao C, Liu L
International journal of molecular sciences 2016 Nov 2;17(11)
International journal of molecular sciences 2016 Nov 2;17(11)
Overexpression of myosin VI regulates gastric cancer cell progression.
Wang Z, Ying M, Wu Q, Wang R, Li Y
Gene 2016 Nov 15;593(1):100-109
Gene 2016 Nov 15;593(1):100-109
17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway.
Wang T, Yang SD, Liu S, Wang H, Liu H, Ding WY
Medical science monitor : international medical journal of experimental and clinical research 2016 Nov 12;22:4312-4322
Medical science monitor : international medical journal of experimental and clinical research 2016 Nov 12;22:4312-4322
The effects of the 5-HT2A receptor antagonist sarpogrelate hydrochloride on chronic hypoxic pulmonary hypertension in rats.
Geng J, Fan FL, He S, Liu Y, Meng Y, Tian H, Zhang D, Ma Q, Zhang JB, Tian HY
Experimental lung research 2016 May;42(4):190-8
Experimental lung research 2016 May;42(4):190-8
piR-651 and its function in 95-D lung cancer cells.
Yao J, Wang YW, Fang BB, Zhang SJ, Cheng BL
Biomedical reports 2016 May;4(5):546-550
Biomedical reports 2016 May;4(5):546-550
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Si L, Zheng L, Xu L, Yin L, Han X, Qi Y, Xu Y, Wang C, Peng J
European journal of pharmacology 2016 Mar 5;774:105-17
European journal of pharmacology 2016 Mar 5;774:105-17
REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling.
Song Z, Zhu T, Zhou X, Barrow P, Yang W, Cui Y, Yang L, Zhao D
Oncotarget 2016 Mar 15;7(11):12035-52
Oncotarget 2016 Mar 15;7(11):12035-52
Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death.
Wang K, Zhang C, Bao J, Jia X, Liang Y, Wang X, Chen M, Su H, Li P, Wan JB, He C
Scientific reports 2016 Jun 6;6:26064
Scientific reports 2016 Jun 6;6:26064
Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.
Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X, Zhang J, Ji L, Ren T, An J, Liu B, Nie Y, Xing J
Autophagy 2016 Jun 2;12(6):999-1014
Autophagy 2016 Jun 2;12(6):999-1014
Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model.
Liang Y, Zhu F, Zhang H, Chen D, Zhang X, Gao Q, Li Y
Scientific reports 2016 Jul 5;6:29479
Scientific reports 2016 Jul 5;6:29479
Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.
Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D, Zhou X
Radiation research 2016 Jan;185(1):77-86
Radiation research 2016 Jan;185(1):77-86
miR-27a-mediated antiproliferative effects of metformin on the breast cancer cell line MCF-7.
Zhao W, Zhang X, Liu J, Sun B, Tang H, Zhang H
Oncology reports 2016 Dec;36(6):3691-3699
Oncology reports 2016 Dec;36(6):3691-3699
Inhibition of Poly(ADP-Ribose) Polymerase-1 Protects Chronic Alcoholic Liver Injury.
Zhang Y, Wang C, Tian Y, Zhang F, Xu W, Li X, Shu Z, Wang Y, Huang K, Huang D
The American journal of pathology 2016 Dec;186(12):3117-3130
The American journal of pathology 2016 Dec;186(12):3117-3130
Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.
Song X, Shi Q, Liu Z, Wang Y, Wang Y, Song E, Song Y
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Ju D, Yamaguchi F, Zhan G, Higuchi T, Asakura T, Morita A, Orimo H, Hu S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):10415-26
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):10415-26
Androgen-induced miR-135a acts as a tumor suppressor through downregulating RBAK and MMP11, and mediates resistance to androgen deprivation therapy.
Wan X, Pu H, Huang W, Yang S, Zhang Y, Kong Z, Yang Z, Zhao P, Li A, Li T, Li Y
Oncotarget 2016 Aug 9;7(32):51284-51300
Oncotarget 2016 Aug 9;7(32):51284-51300
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
DU Q, Hao C, Gou J, Li X, Zou K, He X, Li Z
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H
Drug design, development and therapy 2015;9:5911-23
Drug design, development and therapy 2015;9:5911-23
PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways.
Piao MX, Bai JW, Zhang PF, Zhang YZ
International journal of clinical and experimental pathology 2015;8(3):2787-94
International journal of clinical and experimental pathology 2015;8(3):2787-94
Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells.
Wang B, Zhao MZ, Cui NP, Lin DD, Zhang AY, Qin Y, Liu CY, Yan WT, Shi JH, Chen BP
FEBS open bio 2015;5:147-54
FEBS open bio 2015;5:147-54
Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy.
Shan H, Yan R, Diao J, Lin L, Wang S, Zhang M, Zhang R, Wei J
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2015;31:85-91
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2015;31:85-91
Huaier Aqueous Extract Induces Hepatocellular Carcinoma Cells Arrest in S Phase via JNK Signaling Pathway.
Zhang C, Zhang J, Li X, Sun N, Yu R, Zhao B, Yu D, Cheng Y, Liu Y
Evidence-based complementary and alternative medicine : eCAM 2015;2015:171356
Evidence-based complementary and alternative medicine : eCAM 2015;2015:171356
Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway.
Chen T, Wang C, Liu Q, Meng Q, Sun H, Huo X, Sun P, Peng J, Liu Z, Yang X, Liu K
Cancer biology & therapy 2015;16(1):106-14
Cancer biology & therapy 2015;16(1):106-14
RhNRG-1β Protects the Myocardium against Irradiation-Induced Damage via the ErbB2-ERK-SIRT1 Signaling Pathway.
Gu A, Jie Y, Sun L, Zhao S, E M, You Q
PloS one 2015;10(9):e0137337
PloS one 2015;10(9):e0137337
REV3L, a promising target in regulating the chemosensitivity of cervical cancer cells.
Yang L, Shi T, Liu F, Ren C, Wang Z, Li Y, Tu X, Yang G, Cheng X
PloS one 2015;10(3):e0120334
PloS one 2015;10(3):e0120334
Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cells.
Li J, Yang D, Wang W, Piao S, Zhou J, Saiyin W, Zheng C, Sun H, Li Y
Journal of experimental & clinical cancer research : CR 2015 Sep 11;34(1):97
Journal of experimental & clinical cancer research : CR 2015 Sep 11;34(1):97
RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.
Jin Y, Cao B, Zhang M, Zhan Q, Herman JG, Yu M, Guo M
Genes & cancer 2015 May;6(5-6):231-40
Genes & cancer 2015 May;6(5-6):231-40
Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.
Xie X, Zhang J, Chen D, Pan H, Wu Z, Ge D, Yang G
Shock (Augusta, Ga.) 2015 May;43(5):490-6
Shock (Augusta, Ga.) 2015 May;43(5):490-6
The role of visfatin on the regulation of inflammation and apoptosis in the spleen of LPS-treated rats.
Xiao K, Zou WH, Yang Z, Rehman ZU, Ansari AR, Yuan HR, Zhou Y, Cui L, Peng KM, Song H
Cell and tissue research 2015 Feb;359(2):605-618
Cell and tissue research 2015 Feb;359(2):605-618
Ginsenosides Rg1 from Panax ginseng: A Potential Therapy for Acute Liver Failure Patients?
Zhao J, Shi Z, Liu S, Li J, Huang W
Evidence-based complementary and alternative medicine : eCAM 2014;2014:538059
Evidence-based complementary and alternative medicine : eCAM 2014;2014:538059
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, Qi Y, Zhao Y, Peng J, Sun C
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways.
Li J, Liang X, Yang X
Oncology reports 2012 Aug;28(2):501-10
Oncology reports 2012 Aug;28(2):501-10
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- Proteintech Group (provider)
- Main image
- Experimental details
- The Caspase 3, p17-specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Caspase 3, p17-specific. This antibody recognizes human, mouse, rat antigen. The Caspase 3, p17-specific antibody has been validated for the following applications: ELISA, WB analysis.
