BMS1040

antibody from Invitrogen Antibodies

Targeting: CASP3 apopain, CPP32, CPP32B, Yama

No application information provided.

Antibody Data

Product number

BMS1040

Provider

Invitrogen Antibodies

Product name

Caspase 3 Monoclonal Antibody (MAR-1), eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

Description: Caspases are present in all cells, recruitment of these proteases to oligomerized receptors leads to activation accompanied by autoproteolytic cleavage. Active caspases can proteolyze additional caspases generating a caspase cascade that cleaves proteins critical for cell survival. The final outcome of this signaling pathway is a form of controlled cell death termed apoptosis. The subgroup of caspases involved in apoptosis is called initiators or effectors. Caspase-3 cleaves substrate at the carboxyl terminus of aspartate residues. Active caspase-3 has two active sites and consists of two identical large (~ 20 kDa) and two identical small (~ 10 kDa) subunits that are derived from two precursor caspase-3 polypeptides. Caspase-3 is proteolytically activated by other caspases.

Antibody clone number

1-Mar

Concentration

1 mg/mL