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- NB100-56708 - Provider product page
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- Novus Biologicals
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- Mouse Monoclonal Caspase-3 Antibody
- Antibody type
- Monoclonal
Submitted references Heparin Attenuates Visceral Apoptosis in a Swine Model of Hemorrhagic Shock and Reperfusion Injury.
A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis.
Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors.
Cepharanthine hydrochloride induces mitophagy targeting GPR30 in hepatocellular carcinoma (HCC).
Novel plant microRNAs from broccoletti sprouts do not show cross-kingdom regulation of pancreatic cancer.
YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells.
TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis.
Evaluation of preclinical efficacy of everolimus and pasireotide in thyroid cancer cell lines and xenograft models.
Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats.
In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells.
Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats.
Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells.
Cepharanthine hydrochloride degrades polyglutamine-expanded androgen receptor proteins through an autophagy pathway in neuron cells.
Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex.
Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury.
Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status.
Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells.
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.
Mifepristone mediates anti-proliferative effect on ovarian mesenchymal stem/stromal cells from female BRCA1-/2- carriers.
Pemetrexed exerts anticancer effects by inducing G(0)/G(1)-phase cell cycle arrest and activating the NOXA/Mcl-1 axis in human esophageal squamous cell carcinoma cells.
Degradation of Mitochondria and Oxidative Stress as the Main Mechanism of Toxicity of Pristine Graphene on U87 Glioblastoma Cells and Tumors and HS-5 Cells.
Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus.
Pro-apoptotic effect of haem oxygenase-1 in human colorectal carcinoma cells via endoplasmic reticular stress.
Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes.
Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism.
VEGFC/VEGFR3 Signaling Regulates Mouse Spermatogonial Cell Proliferation via the Activation of AKT/MAPK and Cyclin D1 Pathway and Mediates the Apoptosis by affecting Caspase 3/9 and Bcl-2.
Synergistic effects of tetrandrine combined with ionizing radiation on a murine colorectal carcinoma‑bearing mouse model.
Exogenous C₈-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells.
Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress.
E3 ubiquitin ligase HECW2 targets PCNA and lamin B1.
Anticancer activity of a novel small molecule tubulin inhibitor STK899704.
Cyclin K dependent regulation of Aurora B affects apoptosis and proliferation by induction of mitotic catastrophe in prostate cancer.
Pteisolic acid G, a novel ent-kaurane diterpenoid, inhibits viability and induces apoptosis in human colorectal carcinoma cells.
Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation.
A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression.
The 1-Tosylpentan-3-one Protects against 6-Hydroxydopamine-Induced Neurotoxicity.
CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis.
miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin.
Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms.
Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells.
An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells.
OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53.
Afatinib down-regulates MCL-1 expression through the PERK-eIF2α-ATF4 axis and leads to apoptosis in head and neck squamous cell carcinoma.
Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action.
Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.
Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.
Epigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition.
Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential.
miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1.
Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB.
Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells.
Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution.
Antiviral Activity of a Novel Compound CW-33 against Japanese Encephalitis Virus through Inhibiting Intracellular Calcium Overload.
MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer.
Ex vivo apoptotic and autophagic influence of an estradiol analogue on platelets.
Comparison of Immunomodulatory and Anticancer Activities in Different Strains of Tremella fuciformis Berk.
In vitro and in vivo effects of graphene oxide and reduced graphene oxide on glioblastoma.
Inhibition of Notch1 signaling overcomes resistance to the death ligand Trail by specificity protein 1-dependent upregulation of death receptor 5.
Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells.
Piperlongumine and immune cytokine TRAIL synergize to promote tumor death.
MK-2206 induces apoptosis of AML cells and enhances the cytotoxicity of cytarabine.
p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells.
Macrophage migration inhibitory factor has a permissive role in concanavalin A-induced cell death of human hepatoma cells through autophagy.
Potential theranostics application of bio-synthesized silver nanoparticles (4-in-1 system).
Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway.
Helicobacter pylori sensitizes TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric epithelial cells through regulation of FLIP.
Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo.
Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway.
Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus.
Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells.
Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: implication of reconstituted tumor microenvironment and multidrug resistance phenotype.
In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells.
Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells.
Angiostatin inhibits activation and migration of neutrophils.
Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer.
RanBP9 overexpression reduces dendritic arbor and spine density.
Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib.
RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice.
Golden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathways.
The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma.
Notch1-dependent regulation of p27 determines cell fate in colorectal cancer.
Antiproliferative activity of methanolic extracts from two green algae, Enteromorpha intestinalis and Rizoclonium riparium on HeLa cells.
Striated muscle activator of Rho signaling is required for myotube survival but does not influence basal protein synthesis or degradation.
A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma.
LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy.
Diphenylhydantoin promotes proliferation in the subventricular zone and dentate gyrus.
p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737.
Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival.
Increased oxidative stress in dystrophin deficient (mdx) mice masticatory muscles.
Interferon regulatory factor 4 (IRF-4) targets IRF-5 to regulate Epstein-Barr virus transformation.
Stress by noise produces differential effects on the proliferation rate of radial astrocytes and survival of neuroblasts in the adult subgranular zone.
Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclear factor-κB down-regulation and caspase-3 activation.
Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts.
CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation.
Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis.
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells.
Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channels.
Lipopolysaccharide extends the lifespan of mouse primary-cultured microglia.
Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax.
Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation.
Monitoring caspase-3 activation with a multimodality imaging sensor in living subjects.
Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells.
Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease.
Comparison of the cardiac effects between quinazoline-based alpha1-adrenoceptor antagonists on occlusion-reperfusion injury.
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis.
Chondroitin-4-sulphate reduced oxidative injury in caerulein-induced pancreatitis in mice: the involvement of NF-kappaB translocation and apoptosis activation.
The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells.
Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage.
CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
Platelet-endothelial cell adhesion molecule-1-directed endothelial targeting of superoxide dismutase alleviates oxidative stress caused by either extracellular or intracellular superoxide.
Pinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells.
Lipolysis products from triglyceride-rich lipoproteins increase endothelial permeability, perturb zonula occludens-1 and F-actin, and induce apoptosis.
The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.
Protein expression profiling and molecular classification of gastric cancer by the tissue array method.
Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics.
Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite.
Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin.
The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression.
The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression.
Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol.
Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells.
Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence.
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.
YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells.
Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells.
Induction of endothelial cell apoptosis by lipid hydroperoxide-derived bifunctional electrophiles.
The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice.
Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells.
Synergism of Rana catesbeiana ribonuclease and IFN-gamma triggers distinct death machineries in different human cancer cells.
Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation.
Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3.
Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species.
Reversal of Taxol resistance in hepatoma by cyclosporin A: involvement of the PI-3 kinase-AKT 1 pathway.
Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells.
Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells.
Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.
Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.
Therapeutic time window of adenovirus-mediated GDNF gene transfer after transient middle cerebral artery occlusion in rat.
Therapeutic time window of adenovirus-mediated GDNF gene transfer after transient middle cerebral artery occlusion in rat.
The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells.
The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change.
Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cells.
Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax.
de Jesus-Silva SG, de Moraes Silva MA, Carbonel AAF, Grillo Filho GFR, Grigório TS, Simões MJ, Cardoso RS, Fagundes DJ
Annals of vascular surgery 2020 Mar 14;
Annals of vascular surgery 2020 Mar 14;
A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis.
Lai CH, Chen RY, Hsieh HP, Tsai SJ, Chang KC, Yen CJ, Huang YC, Liu YW, Lee JC, Lai YC, Hung LY, Lin BW
Cancer letters 2020 Mar 1;472:97-107
Cancer letters 2020 Mar 1;472:97-107
Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors.
Nepali K, Chang TY, Lai MJ, Hsu KC, Yen Y, Lin TE, Lee SB, Liou JP
European journal of medicinal chemistry 2020 Jun 15;196:112291
European journal of medicinal chemistry 2020 Jun 15;196:112291
Cepharanthine hydrochloride induces mitophagy targeting GPR30 in hepatocellular carcinoma (HCC).
Wang Y, Su GF, Huang ZX, Wang ZG, Zhou PJ, Fan JL, Wang YF
Expert opinion on therapeutic targets 2020 Apr;24(4):389-402
Expert opinion on therapeutic targets 2020 Apr;24(4):389-402
Novel plant microRNAs from broccoletti sprouts do not show cross-kingdom regulation of pancreatic cancer.
Xiao X, Sticht C, Yin L, Liu L, Karakhanova S, Yin Y, Georgikou C, Gladkich J, Gross W, Gretz N, Herr I
Oncotarget 2020 Apr 7;11(14):1203-1217
Oncotarget 2020 Apr 7;11(14):1203-1217
YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells.
Wang Y, Guo S, Li D, Tang Y, Li L, Su L, Liu X
Cell death & disease 2020 Apr 17;11(4):242
Cell death & disease 2020 Apr 17;11(4):242
TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis.
Huang HL, Liu YM, Sung TY, Huang TC, Cheng YW, Liou JP, Pan SL
Theranostics 2019;9(22):6676-6689
Theranostics 2019;9(22):6676-6689
Evaluation of preclinical efficacy of everolimus and pasireotide in thyroid cancer cell lines and xenograft models.
Owonikoko TK, Zhang G, Lallani SB, Chen Z, Martinson DE, Khuri FR, Lonial S, Marcus A, Sun SY
PloS one 2019;14(2):e0206309
PloS one 2019;14(2):e0206309
Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats.
Kuthati Y, Goutham Davuluri VN, Yang CP, Chang HC, Chang CP, Wong CS
Journal of pain research 2019;12:2473-2485
Journal of pain research 2019;12:2473-2485
In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells.
Chen JC, Hsieh YY, Lo HL, Li A, Chou CJ, Yang PM
Biomolecules 2019 Sep 9;9(9)
Biomolecules 2019 Sep 9;9(9)
Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats.
Sun CM, Enkhjargal B, Reis C, Zhou KR, Xie ZY, Wu LY, Zhang TY, Zhu QQ, Tang JP, Jiang XD, Zhang JH
CNS neuroscience & therapeutics 2019 Oct;25(10):1162-1172
CNS neuroscience & therapeutics 2019 Oct;25(10):1162-1172
Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells.
Mu N, Lei Y, Wang Y, Wang Y, Duan Q, Ma G, Liu X, Su L
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):798-811
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):798-811
Cepharanthine hydrochloride degrades polyglutamine-expanded androgen receptor proteins through an autophagy pathway in neuron cells.
Wang Y, Su G, Huang Z, Fan J, Wang Y
European journal of pharmacology 2019 Oct 15;861:172534
European journal of pharmacology 2019 Oct 15;861:172534
Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex.
Ye SY, Apple JE, Ren X, Tang FL, Yao LL, Wang YG, Mei L, Zhou YG, Xiong WC
Journal of neuroinflammation 2019 Nov 26;16(1):235
Journal of neuroinflammation 2019 Nov 26;16(1):235
Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury.
Nyunt T, Britton M, Wanichthanarak K, Budamagunta M, Voss JC, Wilson DW, Rutledge JC, Aung HH
Free radical biology & medicine 2019 Nov 1;143:25-46
Free radical biology & medicine 2019 Nov 1;143:25-46
Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status.
Chao MW, Chang LH, Tu HJ, Chang CD, Lai MJ, Chen YY, Liou JP, Teng CM, Pan SL
Clinical epigenetics 2019 May 29;11(1):85
Clinical epigenetics 2019 May 29;11(1):85
Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells.
An W, Yao S, Sun X, Hou Z, Lin Y, Su L, Liu X
Journal of experimental & clinical cancer research : CR 2019 May 2;38(1):181
Journal of experimental & clinical cancer research : CR 2019 May 2;38(1):181
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.
Burgener SS, Leborgne NGF, Snipas SJ, Salvesen GS, Bird PI, Benarafa C
Cell reports 2019 Jun 18;27(12):3646-3656.e5
Cell reports 2019 Jun 18;27(12):3646-3656.e5
Mifepristone mediates anti-proliferative effect on ovarian mesenchymal stem/stromal cells from female BRCA1-/2- carriers.
Ponandai-Srinivasan S, Lalitkumar PG, Garcia L, Varghese SJ, Carlson JW, Gemzell-Danielsson K, Floter Radestad A
Acta obstetricia et gynecologica Scandinavica 2019 Feb;98(2):250-261
Acta obstetricia et gynecologica Scandinavica 2019 Feb;98(2):250-261
Pemetrexed exerts anticancer effects by inducing G(0)/G(1)-phase cell cycle arrest and activating the NOXA/Mcl-1 axis in human esophageal squamous cell carcinoma cells.
Li X, Song H, Kong F, Guo Y, Chen Y, Zhang L, Gao D, Zhao X, Zhang H
Oncology letters 2019 Feb;17(2):1851-1858
Oncology letters 2019 Feb;17(2):1851-1858
Degradation of Mitochondria and Oxidative Stress as the Main Mechanism of Toxicity of Pristine Graphene on U87 Glioblastoma Cells and Tumors and HS-5 Cells.
Jaworski S, Strojny B, Sawosz E, Wierzbicki M, Grodzik M, Kutwin M, Daniluk K, Chwalibog A
International journal of molecular sciences 2019 Feb 2;20(3)
International journal of molecular sciences 2019 Feb 2;20(3)
Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus.
Jia R, Jia N, Yang F, Liu Z, Li R, Jiang Y, Zhao J, Wang L, Zhang S, Zhang Z, Zhang H, Wu S, Gao F, Jiang W
Cellular and molecular neurobiology 2019 Aug;39(6):857-869
Cellular and molecular neurobiology 2019 Aug;39(6):857-869
Pro-apoptotic effect of haem oxygenase-1 in human colorectal carcinoma cells via endoplasmic reticular stress.
Wu MS, Chien CC, Chang J, Chen YC
Journal of cellular and molecular medicine 2019 Aug;23(8):5692-5704
Journal of cellular and molecular medicine 2019 Aug;23(8):5692-5704
Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes.
Chou CK, Huang HW, Yang CF, Dahms HU, Liang SS, Wang TN, Kuo PL, Hsi E, Tsai EM, Chiu CC
Environmental toxicology 2019 Apr;34(4):401-414
Environmental toxicology 2019 Apr;34(4):401-414
Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism.
Fauzia E, Barbhuyan TK, Shrivastava AK, Kumar M, Garg P, Khan MA, Robertson AAB, Raza SS
Frontiers in pharmacology 2018;9:1034
Frontiers in pharmacology 2018;9:1034
VEGFC/VEGFR3 Signaling Regulates Mouse Spermatogonial Cell Proliferation via the Activation of AKT/MAPK and Cyclin D1 Pathway and Mediates the Apoptosis by affecting Caspase 3/9 and Bcl-2.
Zhao L, Zhu Z, Yao C, Huang Y, Zhi E, Chen H, Tian R, Li P, Yuan Q, Xue Y, Wan Z, Yang C, Gong Y, He Z, Li Z
Cell cycle (Georgetown, Tex.) 2018;17(2):225-239
Cell cycle (Georgetown, Tex.) 2018;17(2):225-239
Synergistic effects of tetrandrine combined with ionizing radiation on a murine colorectal carcinoma‑bearing mouse model.
Lin WC, Wang WH, Lin YH, Leu JD, Cheng SY, Chen YJ, Hwang JJ
Oncology reports 2018 Sep;40(3):1390-1400
Oncology reports 2018 Sep;40(3):1390-1400
Exogenous C₈-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells.
Chang YC, Fong Y, Tsai EM, Chang YG, Chou HL, Wu CY, Teng YN, Liu TC, Yuan SS, Chiu CC
International journal of molecular sciences 2018 Oct 2;19(10)
International journal of molecular sciences 2018 Oct 2;19(10)
Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress.
Chou CK, Liu W, Hong YJ, Dahms HU, Chiu CH, Chang WT, Chien CM, Yen CH, Cheng YB, Chiu CC
International journal of molecular sciences 2018 Jun 21;19(7)
International journal of molecular sciences 2018 Jun 21;19(7)
E3 ubiquitin ligase HECW2 targets PCNA and lamin B1.
Krishnamoorthy V, Khanna R, Parnaik VK
Biochimica et biophysica acta. Molecular cell research 2018 Aug;1865(8):1088-1104
Biochimica et biophysica acta. Molecular cell research 2018 Aug;1865(8):1088-1104
Anticancer activity of a novel small molecule tubulin inhibitor STK899704.
Sakchaisri K, Kim SO, Hwang J, Soung NK, Lee KH, Choi TW, Lee Y, Park CM, Thimmegowda NR, Lee PY, Shwetha B, Srinivasrao G, Pham TT, Jang JH, Yum HW, Surh YJ, Lee KS, Park H, Kim SJ, Kwon YT, Ahn JS, Kim BY
PloS one 2017;12(3):e0173311
PloS one 2017;12(3):e0173311
Cyclin K dependent regulation of Aurora B affects apoptosis and proliferation by induction of mitotic catastrophe in prostate cancer.
Schecher S, Walter B, Falkenstein M, Macher-Goeppinger S, Stenzel P, Krümpelmann K, Hadaschik B, Perner S, Kristiansen G, Duensing S, Roth W, Tagscherer KE
International journal of cancer 2017 Oct 15;141(8):1643-1653
International journal of cancer 2017 Oct 15;141(8):1643-1653
Pteisolic acid G, a novel ent-kaurane diterpenoid, inhibits viability and induces apoptosis in human colorectal carcinoma cells.
Qiu S, Wu X, Liao H, Zeng X, Zhang S, Lu X, He X, Zhang X, Ye W, Wu H, Zhu X
Oncology letters 2017 Nov;14(5):5540-5548
Oncology letters 2017 Nov;14(5):5540-5548
Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation.
Shi P, Oh YT, Deng L, Zhang G, Qian G, Zhang S, Ren H, Wu G, Legendre B Jr, Anderson E, Ramalingam SS, Owonikoko TK, Chen M, Sun SY
Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Nov 1;23(21):6567-6579
Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Nov 1;23(21):6567-6579
A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression.
Chang WT, Liu W, Chiu YH, Chen BH, Chuang SC, Chen YC, Hsu YT, Lu MJ, Chiou SJ, Chou CK, Chiu CC
Molecules (Basel, Switzerland) 2017 May 21;22(5)
Molecules (Basel, Switzerland) 2017 May 21;22(5)
The 1-Tosylpentan-3-one Protects against 6-Hydroxydopamine-Induced Neurotoxicity.
Kao CJ, Chen WF, Guo BL, Feng CW, Hung HC, Yang WY, Sung CS, Tsui KH, Chu H, Chen NF, Wen ZH
International journal of molecular sciences 2017 May 19;18(5)
International journal of molecular sciences 2017 May 19;18(5)
CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis.
Wang YY, Chen YK, Hu SC, Hsu YL, Tsai CH, Chi TC, Huang WL, Hsieh PW, Yuan SF
Cancer chemotherapy and pharmacology 2017 Jun;79(6):1129-1140
Cancer chemotherapy and pharmacology 2017 Jun;79(6):1129-1140
miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin.
Patel N, Garikapati KR, Pandita RK, Singh DK, Pandita TK, Bhadra U, Bhadra MP
Scientific reports 2017 Jun 27;7(1):4263
Scientific reports 2017 Jun 27;7(1):4263
Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms.
Nepali K, Lee HY, Lai MJ, Ojha R, Wu TY, Wu GX, Chen MC, Liou JP
European journal of medicinal chemistry 2017 Feb 15;127:115-127
European journal of medicinal chemistry 2017 Feb 15;127:115-127
Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells.
Chao MW, Chen TH, Huang HL, Chang YW, HuangFu WC, Lee YC, Teng CM, Pan SL
Scientific reports 2017 Apr 7;7:46134
Scientific reports 2017 Apr 7;7:46134
An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells.
Chao MW, Huang HL, HuangFu WC, Hsu KC, Liu YM, Wu YW, Lin CF, Chen YL, Lai MJ, Lee HY, Liou JP, Teng CM, Yang CR
Oncotarget 2017 Apr 25;8(17):27772-27785
Oncotarget 2017 Apr 25;8(17):27772-27785
OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53.
Omar HA, Tolba MF, Hung JH, Al-Tel TH
Frontiers in pharmacology 2016;7:463
Frontiers in pharmacology 2016;7:463
Afatinib down-regulates MCL-1 expression through the PERK-eIF2α-ATF4 axis and leads to apoptosis in head and neck squamous cell carcinoma.
Liu X, Lv Z, Zou J, Liu X, Ma J, Wang J, Sa N, Jing P, Xu W
American journal of cancer research 2016;6(8):1708-19
American journal of cancer research 2016;6(8):1708-19
Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action.
Huang X, Huang R, Gou S, Wang Z, Liao Z, Wang H
Bioconjugate chemistry 2016 Sep 21;27(9):2132-48
Bioconjugate chemistry 2016 Sep 21;27(9):2132-48
Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.
Ren H, Guo H, Thakur A, Zhang S, Wang T, Liang Y, Shi P, Gao L, Liu F, Feng J, Chen T, Yang T, Shang D, Liu JJ, Xu F, Chen M
Oncotarget 2016 Oct 11;7(41):67277-67287
Oncotarget 2016 Oct 11;7(41):67277-67287
Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.
Shi P, Oh YT, Zhang G, Yao W, Yue P, Li Y, Kanteti R, Riehm J, Salgia R, Owonikoko TK, Ramalingam SS, Chen M, Sun SY
Cancer letters 2016 Oct 1;380(2):494-504
Cancer letters 2016 Oct 1;380(2):494-504
Epigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition.
Huang YC, Lee CT, Lee JC, Liu YW, Chen YJ, Tseng JT, Kang JW, Sheu BS, Lin BW, Hung LY
Oncotarget 2016 Nov 22;7(47):76852-76866
Oncotarget 2016 Nov 22;7(47):76852-76866
Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential.
Kwon JJ, Willy JA, Quirin KA, Wek RC, Korc M, Yin XM, Kota J
Oncotarget 2016 Nov 1;7(44):71635-71650
Oncotarget 2016 Nov 1;7(44):71635-71650
miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1.
Patel N, Garikapati KR, Ramaiah MJ, Polavarapu KK, Bhadra U, Bhadra MP
Life sciences 2016 Nov 1;164:60-70
Life sciences 2016 Nov 1;164:60-70
Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB.
Oliver Metzig M, Fuchs D, Tagscherer KE, Gröne HJ, Schirmacher P, Roth W
Oncogene 2016 Jun 30;35(26):3399-409
Oncogene 2016 Jun 30;35(26):3399-409
Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells.
Chen NC, Chyau CC, Lee YJ, Tseng HC, Chou FP
Scientific reports 2016 Feb 3;6:20417
Scientific reports 2016 Feb 3;6:20417
Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution.
Ge GZ, Xia HJ, He BL, Zhang HL, Liu WJ, Shao M, Wang CY, Xiao J, Ge F, Li FB, Li Y, Chen C
International journal of cancer 2016 Feb 1;138(3):642-51
International journal of cancer 2016 Feb 1;138(3):642-51
Antiviral Activity of a Novel Compound CW-33 against Japanese Encephalitis Virus through Inhibiting Intracellular Calcium Overload.
Huang SH, Lien JC, Chen CJ, Liu YC, Wang CY, Ping CF, Lin YF, Huang AC, Lin CW
International journal of molecular sciences 2016 Aug 24;17(9)
International journal of molecular sciences 2016 Aug 24;17(9)
MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer.
Huang HL, Chao MW, Li YC, Chang LH, Chen CH, Chen MC, Cheng CC, Liou JP, Teng CM, Pan SL
Scientific reports 2016 Aug 16;6:31664
Scientific reports 2016 Aug 16;6:31664
Ex vivo apoptotic and autophagic influence of an estradiol analogue on platelets.
Repsold L, Pretorius E, Joubert AM
Experimental hematology & oncology 2015;5:18
Experimental hematology & oncology 2015;5:18
Comparison of Immunomodulatory and Anticancer Activities in Different Strains of Tremella fuciformis Berk.
Han CK, Chiang HC, Lin CY, Tang CH, Lee H, Huang DD, Zeng YR, Chuang TN, Huang YL
The American journal of Chinese medicine 2015;43(8):1637-55
The American journal of Chinese medicine 2015;43(8):1637-55
In vitro and in vivo effects of graphene oxide and reduced graphene oxide on glioblastoma.
Jaworski S, Sawosz E, Kutwin M, Wierzbicki M, Hinzmann M, Grodzik M, Winnicka A, Lipińska L, Włodyga K, Chwalibog A
International journal of nanomedicine 2015;10:1585-96
International journal of nanomedicine 2015;10:1585-96
Inhibition of Notch1 signaling overcomes resistance to the death ligand Trail by specificity protein 1-dependent upregulation of death receptor 5.
Fassl A, Tagscherer KE, Richter J, De-Castro Arce J, Savini C, Rösl F, Roth W
Cell death & disease 2015 Oct 15;6:e1921
Cell death & disease 2015 Oct 15;6:e1921
Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells.
Liu X, Guo S, Liu X, Su L
Apoptosis : an international journal on programmed cell death 2015 Nov;20(11):1499-507
Apoptosis : an international journal on programmed cell death 2015 Nov;20(11):1499-507
Piperlongumine and immune cytokine TRAIL synergize to promote tumor death.
Li J, Sharkey CC, King MR
Scientific reports 2015 May 18;5:9987
Scientific reports 2015 May 18;5:9987
MK-2206 induces apoptosis of AML cells and enhances the cytotoxicity of cytarabine.
Lu JW, Lin YM, Lai YL, Chen CY, Hu CY, Tien HF, Ou DL, Lin LI
Medical oncology (Northwood, London, England) 2015 Jul;32(7):206
Medical oncology (Northwood, London, England) 2015 Jul;32(7):206
p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
Roobol A, Roobol J, Bastide A, Knight JR, Willis AE, Smales CM
The Biochemical journal 2015 Jan 15;465(2):213-25
The Biochemical journal 2015 Jan 15;465(2):213-25
S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells.
Liu TP, Lo HL, Wei LS, Hsiao HH, Yang PM
Anti-cancer drugs 2015 Feb;26(2):139-47
Anti-cancer drugs 2015 Feb;26(2):139-47
Macrophage migration inhibitory factor has a permissive role in concanavalin A-induced cell death of human hepatoma cells through autophagy.
Lai YC, Chuang YC, Chang CP, Yeh TM
Cell death & disease 2015 Dec 3;6:e2008
Cell death & disease 2015 Dec 3;6:e2008
Potential theranostics application of bio-synthesized silver nanoparticles (4-in-1 system).
Mukherjee S, Chowdhury D, Kotcherlakota R, Patra S, B V, Bhadra MP, Sreedhar B, Patra CR
Theranostics 2014;4(3):316-35
Theranostics 2014;4(3):316-35
Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway.
Yi L, Zongyuan Y, Cheng G, Lingyun Z, Guilian Y, Wei G
Cancer science 2014 May;105(5):520-7
Cancer science 2014 May;105(5):520-7
Helicobacter pylori sensitizes TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric epithelial cells through regulation of FLIP.
Lin WC, Tsai HF, Liao HJ, Tang CH, Wu YY, Hsu PI, Cheng AL, Hsu PN
Cell death & disease 2014 Mar 6;5:e1109
Cell death & disease 2014 Mar 6;5:e1109
Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo.
Chen CH, Chen MC, Wang JC, Tsai AC, Chen CS, Liou JP, Pan SL, Teng CM
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Mar 1;20(5):1274-1287
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Mar 1;20(5):1274-1287
Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway.
Huang CK, Yang CY, Jeng YM, Chen CL, Wu HH, Chang YC, Ma C, Kuo WH, Chang KJ, Shew JY, Lee WH
Oncogene 2014 Jun 5;33(23):2968-77
Oncogene 2014 Jun 5;33(23):2968-77
Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus.
Xia M, Meng G, Jiang A, Chen A, Dahlhaus M, Gonzalez P, Beltinger C, Wei J
Oncotarget 2014 Jun 15;5(11):3907-18
Oncotarget 2014 Jun 15;5(11):3907-18
Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells.
Yan J, Zhong N, Liu G, Chen K, Liu X, Su L, Singhal S
Cell death & disease 2014 Jul 3;5:e1316
Cell death & disease 2014 Jul 3;5:e1316
Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: implication of reconstituted tumor microenvironment and multidrug resistance phenotype.
Kant S, Kumar A, Singh SM
Biochimica et biophysica acta 2014 Jan;1840(1):294-302
Biochimica et biophysica acta 2014 Jan;1840(1):294-302
In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells.
Tsai AC, Pai HC, Wang CY, Liou JP, Teng CM, Wang JC, Pan SL
British journal of pharmacology 2014 Jan;171(1):122-33
British journal of pharmacology 2014 Jan;171(1):122-33
Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells.
Zhao X, Liu X, Su L
Journal of experimental & clinical cancer research : CR 2014 Jan 6;33:3
Journal of experimental & clinical cancer research : CR 2014 Jan 6;33:3
Angiostatin inhibits activation and migration of neutrophils.
Aulakh GK, Balachandran Y, Liu L, Singh B
Cell and tissue research 2014 Feb;355(2):375-96
Cell and tissue research 2014 Feb;355(2):375-96
Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer.
Owonikoko TK, Zhang G, Deng X, Rossi MR, Switchenko JM, Doho GH, Chen Z, Kim S, Strychor S, Christner SM, Beumer J, Li C, Yue P, Chen A, Sica GL, Ramalingam SS, Kowalski J, Khuri FR, Sun SY
Cancer medicine 2014 Dec;3(6):1579-94
Cancer medicine 2014 Dec;3(6):1579-94
RanBP9 overexpression reduces dendritic arbor and spine density.
Wang H, Lewsadder M, Dorn E, Xu S, Lakshmana MK
Neuroscience 2014 Apr 18;265:253-62
Neuroscience 2014 Apr 18;265:253-62
Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib.
Tsai AC, Wang CY, Liou JP, Pai HC, Hsiao CJ, Chang JY, Wang JC, Teng CM, Pan SL
Cell death & disease 2014 Apr 10;5:e1162
Cell death & disease 2014 Apr 10;5:e1162
RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice.
Palavicini JP, Lloyd BN, Hayes CD, Bianchi E, Kang DE, Dawson-Scully K, Lakshmana MK
PloS one 2013;8(6):e66908
PloS one 2013;8(6):e66908
Golden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathways.
Chiu CC, Haung JW, Chang FR, Huang KJ, Huang HM, Huang HW, Chou CK, Wu YC, Chang HW
PloS one 2013;8(5):e64739
PloS one 2013;8(5):e64739
The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma.
Weissinger D, Tagscherer KE, Macher-Göppinger S, Haferkamp A, Wagener N, Roth W
Molecular cancer 2013 Oct 10;12(1):120
Molecular cancer 2013 Oct 10;12(1):120
Notch1-dependent regulation of p27 determines cell fate in colorectal cancer.
Hristova NR, Tagscherer KE, Fassl A, Kopitz J, Roth W
International journal of oncology 2013 Dec;43(6):1967-75
International journal of oncology 2013 Dec;43(6):1967-75
Antiproliferative activity of methanolic extracts from two green algae, Enteromorpha intestinalis and Rizoclonium riparium on HeLa cells.
Paul S, Kundu R
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2013 Dec 19;21(1):72
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2013 Dec 19;21(1):72
Striated muscle activator of Rho signaling is required for myotube survival but does not influence basal protein synthesis or degradation.
Wallace MA, Russell AP
American journal of physiology. Cell physiology 2013 Aug 15;305(4):C414-26
American journal of physiology. Cell physiology 2013 Aug 15;305(4):C414-26
A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma.
Hossain A, Radwan FF, Doonan BP, God JM, Zhang L, Bell PD, Haque A
Apoptosis : an international journal on programmed cell death 2012 Oct;17(10):1066-78
Apoptosis : an international journal on programmed cell death 2012 Oct;17(10):1066-78
LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy.
Saha T
Autophagy 2012 Nov;8(11):1643-56
Autophagy 2012 Nov;8(11):1643-56
Diphenylhydantoin promotes proliferation in the subventricular zone and dentate gyrus.
Galvez-Contreras AY, Gonzalez-Castaneda RE, Luquin S, Guzman-Muniz J, Moy-Lopez NA, Ramos-Zuniga R, Gonzalez-Perez O
American journal of neuroscience 2012 Mar 6;3(1):1-9
American journal of neuroscience 2012 Mar 6;3(1):1-9
p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737.
Tagscherer KE, Fassl A, Sinkovic T, Combs SE, Roth W
Apoptosis : an international journal on programmed cell death 2012 Feb;17(2):187-99
Apoptosis : an international journal on programmed cell death 2012 Feb;17(2):187-99
Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival.
Schultz CR, Golembieski WA, King DA, Brown SL, Brodie C, Rempel SA
Molecular cancer 2012 Apr 5;11:20
Molecular cancer 2012 Apr 5;11:20
Increased oxidative stress in dystrophin deficient (mdx) mice masticatory muscles.
Spassov A, Gredes T, Gedrange T, Pavlovic D, Lupp A, Kunert-Keil C
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2011 Sep;63(6):549-52
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2011 Sep;63(6):549-52
Interferon regulatory factor 4 (IRF-4) targets IRF-5 to regulate Epstein-Barr virus transformation.
Xu D, Meyer F, Ehlers E, Blasnitz L, Zhang L
The Journal of biological chemistry 2011 May 20;286(20):18261-7
The Journal of biological chemistry 2011 May 20;286(20):18261-7
Stress by noise produces differential effects on the proliferation rate of radial astrocytes and survival of neuroblasts in the adult subgranular zone.
Gonzalez-Perez O, Chavez-Casillas O, Jauregui-Huerta F, Lopez-Virgen V, Guzman-Muniz J, Moy-Lopez N, Gonzalez-Castaneda RE, Luquin S
Neuroscience research 2011 Jul;70(3):243-50
Neuroscience research 2011 Jul;70(3):243-50
Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclear factor-κB down-regulation and caspase-3 activation.
Singer M, Trugnan G, Chelbi-Alix MK
Innate immunity 2011 Aug;17(4):365-74
Innate immunity 2011 Aug;17(4):365-74
Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts.
Fernandez K, Serinagaoglu Y, Hammond S, Martin LT, Martin PT
The American journal of pathology 2010 Jan;176(1):416-34
The American journal of pathology 2010 Jan;176(1):416-34
CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation.
Tsai AC, Pan SL, Sun HL, Wang CY, Peng CY, Wang SW, Chang YL, Kuo SC, Lee KH, Teng CM
The Journal of biological chemistry 2010 Feb 19;285(8):5497-506
The Journal of biological chemistry 2010 Feb 19;285(8):5497-506
Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis.
Joy B, Sivadasan R, Abraham T E, John M, Sobhan PK, Seervi M, T R S
Molecular carcinogenesis 2010 Apr;49(4):324-36
Molecular carcinogenesis 2010 Apr;49(4):324-36
The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells.
Temime-Smaali N, Guittat L, Sidibe A, Shin-ya K, Trentesaux C, Riou JF
PloS one 2009 Sep 9;4(9):e6919
PloS one 2009 Sep 9;4(9):e6919
Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channels.
Chopra B, Georgopoulos NT, Nicholl A, Hinley J, Oleksiewicz MB, Southgate J
Cell proliferation 2009 Oct;42(5):688-700
Cell proliferation 2009 Oct;42(5):688-700
Lipopolysaccharide extends the lifespan of mouse primary-cultured microglia.
Kaneko YS, Nakashima A, Mori K, Nagatsu T, Nagatsu I, Ota A
Brain research 2009 Jul 7;1279:9-20
Brain research 2009 Jul 7;1279:9-20
Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax.
Yui S, Kanamoto R, Saeki T
Nutrition and cancer 2008;60(1):91-6
Nutrition and cancer 2008;60(1):91-6
Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation.
Zou W, Yue P, Khuri FR, Sun SY
Cancer research 2008 Sep 15;68(18):7484-92
Cancer research 2008 Sep 15;68(18):7484-92
Monitoring caspase-3 activation with a multimodality imaging sensor in living subjects.
Ray P, De A, Patel M, Gambhir SS
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Sep 15;14(18):5801-9
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Sep 15;14(18):5801-9
Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells.
Chen TH, Pan SL, Guh JH, Chen CC, Huang YT, Pai HC, Teng CM
Naunyn-Schmiedeberg's archives of pharmacology 2008 Nov;378(5):447-57
Naunyn-Schmiedeberg's archives of pharmacology 2008 Nov;378(5):447-57
Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease.
Louneva N, Cohen JW, Han LY, Talbot K, Wilson RS, Bennett DA, Trojanowski JQ, Arnold SE
The American journal of pathology 2008 Nov;173(5):1488-95
The American journal of pathology 2008 Nov;173(5):1488-95
Comparison of the cardiac effects between quinazoline-based alpha1-adrenoceptor antagonists on occlusion-reperfusion injury.
Lee AS, Su MJ
Journal of biomedical science 2008 Mar;15(2):239-49
Journal of biomedical science 2008 Mar;15(2):239-49
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis.
Gdynia G, Lehmann-Koch J, Sieber S, Tagscherer KE, Fassl A, Zentgraf H, Matsuzawa S, Reed JC, Roth W
Apoptosis : an international journal on programmed cell death 2008 Mar;13(3):437-47
Apoptosis : an international journal on programmed cell death 2008 Mar;13(3):437-47
Chondroitin-4-sulphate reduced oxidative injury in caerulein-induced pancreatitis in mice: the involvement of NF-kappaB translocation and apoptosis activation.
Campo GM, Avenoso A, Campo S, Nastasi G, Traina P, D'Ascola A, Calatroni A
Experimental biology and medicine (Maywood, N.J.) 2008 Jun;233(6):741-52
Experimental biology and medicine (Maywood, N.J.) 2008 Jun;233(6):741-52
The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
Raja SM, Chen S, Yue P, Acker TM, Lefkove B, Arbiser JL, Khuri FR, Sun SY
Molecular cancer therapeutics 2008 Jul;7(7):2212-23
Molecular cancer therapeutics 2008 Jul;7(7):2212-23
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
Liu C, Erlichman C, McDonald CJ, Ingle JN, Zollman P, Iankov I, Russell SJ, Galanis E
Gene therapy 2008 Jul;15(14):1024-34
Gene therapy 2008 Jul;15(14):1024-34
CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells.
Lin YD, Chen S, Yue P, Zou W, Benbrook DM, Liu S, Le TC, Berlin KD, Khuri FR, Sun SY
Cancer research 2008 Jul 1;68(13):5335-44
Cancer research 2008 Jul 1;68(13):5335-44
Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage.
Chen TH, Pan SL, Guh JH, Liao CH, Huang DY, Chen CC, Teng CM
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Jul 1;14(13):4250-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Jul 1;14(13):4250-8
CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.
Wang SW, Pan SL, Huang YC, Guh JH, Chiang PC, Huang DY, Kuo SC, Lee KH, Teng CM
Molecular cancer therapeutics 2008 Feb;7(2):350-60
Molecular cancer therapeutics 2008 Feb;7(2):350-60
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
Hsiao CJ, Ho YF, Hsu JT, Chang WL, Chen YC, Shen YC, Lyu PC, Guh JH
Naunyn-Schmiedeberg's archives of pharmacology 2008 Dec;378(6):599-608
Naunyn-Schmiedeberg's archives of pharmacology 2008 Dec;378(6):599-608
Platelet-endothelial cell adhesion molecule-1-directed endothelial targeting of superoxide dismutase alleviates oxidative stress caused by either extracellular or intracellular superoxide.
Shuvaev VV, Tliba S, Nakada M, Albelda SM, Muzykantov VR
The Journal of pharmacology and experimental therapeutics 2007 Nov;323(2):450-7
The Journal of pharmacology and experimental therapeutics 2007 Nov;323(2):450-7
Pinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells.
Kumar MA, Nair M, Hema PS, Mohan J, Santhoshkumar TR
Molecular carcinogenesis 2007 Mar;46(3):231-41
Molecular carcinogenesis 2007 Mar;46(3):231-41
Lipolysis products from triglyceride-rich lipoproteins increase endothelial permeability, perturb zonula occludens-1 and F-actin, and induce apoptosis.
Eiselein L, Wilson DW, Lamé MW, Rutledge JC
American journal of physiology. Heart and circulatory physiology 2007 Jun;292(6):H2745-53
American journal of physiology. Heart and circulatory physiology 2007 Jun;292(6):H2745-53
The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.
Elrod HA, Lin YD, Yue P, Wang X, Lonial S, Khuri FR, Sun SY
Molecular cancer therapeutics 2007 Jul;6(7):2029-38
Molecular cancer therapeutics 2007 Jul;6(7):2029-38
Protein expression profiling and molecular classification of gastric cancer by the tissue array method.
Lee HS, Cho SB, Lee HE, Kim MA, Kim JH, Park DJ, Kim JH, Yang HK, Lee BL, Kim WH
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Jul 15;13(14):4154-63
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Jul 15;13(14):4154-63
Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics.
Jarskog LF, Gilmore JH, Glantz LA, Gable KL, German TT, Tong RI, Lieberman JA
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007 Jan;32(1):95-102
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007 Jan;32(1):95-102
Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite.
Li JP, Yang JL
Journal of cellular physiology 2007 Aug;212(2):481-8
Journal of cellular physiology 2007 Aug;212(2):481-8
Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin.
Schultze K, Böck B, Eckert A, Oevermann L, Ramacher D, Wiestler O, Roth W
Apoptosis : an international journal on programmed cell death 2006 Sep;11(9):1503-12
Apoptosis : an international journal on programmed cell death 2006 Sep;11(9):1503-12
The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression.
Chiou SH, Yang YP, Lin JC, Hsu CH, Jhang HC, Yang YT, Lee CH, Ho LL, Hsu WM, Ku HH, Chen SJ, Chen SS, Chang MD, Wu CW, Juan LJ
Journal of immunology (Baltimore, Md. : 1950) 2006 Nov 1;177(9):6199-206
Journal of immunology (Baltimore, Md. : 1950) 2006 Nov 1;177(9):6199-206
The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression.
Chiou SH, Yang YP, Lin JC, Hsu CH, Jhang HC, Yang YT, Lee CH, Ho LL, Hsu WM, Ku HH, Chen SJ, Chen SS, Chang MD, Wu CW, Juan LJ
Journal of immunology (Baltimore, Md. : 1950) 2006 Nov 1;177(9):6199-206
Journal of immunology (Baltimore, Md. : 1950) 2006 Nov 1;177(9):6199-206
Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol.
Mohan J, Gandhi AA, Bhavya BC, Rashmi R, Karunagaran D, Indu R, Santhoshkumar TR
The Journal of biological chemistry 2006 Jun 30;281(26):17599-611
The Journal of biological chemistry 2006 Jun 30;281(26):17599-611
Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells.
Chiang PC, Kung FL, Huang DM, Li TK, Fan JR, Pan SL, Shen YC, Guh JH
European journal of pharmacology 2006 Aug 7;542(1-3):22-30
European journal of pharmacology 2006 Aug 7;542(1-3):22-30
Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence.
Douarre C, Gomez D, Morjani H, Zahm JM, O'donohue MF, Eddabra L, Mailliet P, Riou JF, Trentesaux C
Nucleic acids research 2005;33(7):2192-203
Nucleic acids research 2005;33(7):2192-203
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.
Chiang PC, Chien CL, Pan SL, Chen WP, Teng CM, Shen YC, Guh JH
Journal of hepatology 2005 Oct;43(4):679-86
Journal of hepatology 2005 Oct;43(4):679-86
YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells.
Huang YT, Pan SL, Guh JH, Chang YL, Lee FY, Kuo SC, Teng CM
Molecular cancer therapeutics 2005 Oct;4(10):1628-35
Molecular cancer therapeutics 2005 Oct;4(10):1628-35
Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells.
Lee JC, Lee CH, Su CL, Huang CW, Liu HS, Lin CN, Won SJ
Carcinogenesis 2005 Oct;26(10):1716-30
Carcinogenesis 2005 Oct;26(10):1716-30
Induction of endothelial cell apoptosis by lipid hydroperoxide-derived bifunctional electrophiles.
Jian W, Arora JS, Oe T, Shuvaev VV, Blair IA
Free radical biology & medicine 2005 Nov 1;39(9):1162-76
Free radical biology & medicine 2005 Nov 1;39(9):1162-76
The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice.
Hylander BL, Pitoniak R, Penetrante RB, Gibbs JF, Oktay D, Cheng J, Repasky EA
Journal of translational medicine 2005 May 19;3(1):22
Journal of translational medicine 2005 May 19;3(1):22
Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells.
Jin F, Liu X, Zhou Z, Yue P, Lotan R, Khuri FR, Chung LW, Sun SY
Cancer research 2005 Jul 15;65(14):6354-63
Cancer research 2005 Jul 15;65(14):6354-63
Synergism of Rana catesbeiana ribonuclease and IFN-gamma triggers distinct death machineries in different human cancer cells.
Tang CH, Hu CC, Wei CW, Wang JJ
FEBS letters 2005 Jan 3;579(1):265-70
FEBS letters 2005 Jan 3;579(1):265-70
Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation.
Jarskog LF, Selinger ES, Lieberman JA, Gilmore JH
The American journal of psychiatry 2004 Jan;161(1):109-15
The American journal of psychiatry 2004 Jan;161(1):109-15
Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3.
Wu YH, Shih SF, Lin JY
The Journal of biological chemistry 2004 Apr 30;279(18):19264-75
The Journal of biological chemistry 2004 Apr 30;279(18):19264-75
Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species.
Ko CH, Shen SC, Chen YC
Free radical biology & medicine 2004 Apr 1;36(7):897-910
Free radical biology & medicine 2004 Apr 1;36(7):897-910
Reversal of Taxol resistance in hepatoma by cyclosporin A: involvement of the PI-3 kinase-AKT 1 pathway.
Lin HL, Lui WY, Liu TY, Chi CW
British journal of cancer 2003 Mar 24;88(6):973-80
British journal of cancer 2003 Mar 24;88(6):973-80
Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells.
Kim KB, Lotan R, Yue P, Sporn MB, Suh N, Gribble GW, Honda T, Wu GS, Hong WK, Sun SY
Molecular cancer therapeutics 2002 Jan;1(3):177-84
Molecular cancer therapeutics 2002 Jan;1(3):177-84
Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells.
Yamaguchi H, Paranawithana SR, Lee MW, Huang Z, Bhalla KN, Wang HG
Cancer research 2002 Jan 15;62(2):466-71
Cancer research 2002 Jan 15;62(2):466-71
Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.
Chen YC, Shen SC, Lee WR, Hsu FL, Lin HY, Ko CH, Tseng SW
Biochemical pharmacology 2002 Dec 15;64(12):1713-24
Biochemical pharmacology 2002 Dec 15;64(12):1713-24
Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.
Chen YC, Shen SC, Lee WR, Hsu FL, Lin HY, Ko CH, Tseng SW
Biochemical pharmacology 2002 Dec 15;64(12):1713-24
Biochemical pharmacology 2002 Dec 15;64(12):1713-24
Therapeutic time window of adenovirus-mediated GDNF gene transfer after transient middle cerebral artery occlusion in rat.
Zhang WR, Sato K, Iwai M, Nagano I, Manabe Y, Abe K
Brain research 2002 Aug 23;947(1):140-5
Brain research 2002 Aug 23;947(1):140-5
Therapeutic time window of adenovirus-mediated GDNF gene transfer after transient middle cerebral artery occlusion in rat.
Zhang WR, Sato K, Iwai M, Nagano I, Manabe Y, Abe K
Brain research 2002 Aug 23;947(1):140-5
Brain research 2002 Aug 23;947(1):140-5
The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells.
Sun SY, Yue P, Chen X, Hong WK, Lotan R
Cancer research 2002 Apr 15;62(8):2430-6
Cancer research 2002 Apr 15;62(8):2430-6
The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change.
Yamaguchi H, Wang HG
Oncogene 2001 Nov 22;20(53):7779-86
Oncogene 2001 Nov 22;20(53):7779-86
Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cells.
Sun SY, Yue P, Kelloff GJ, Steele VE, Lippman SM, Hong WK, Lotan R
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001 Jun;10(6):595-601
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001 Jun;10(6):595-601
Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax.
Cuddeback SM, Yamaguchi H, Komatsu K, Miyashita T, Yamada M, Wu C, Singh S, Wang HG
The Journal of biological chemistry 2001 Jun 8;276(23):20559-65
The Journal of biological chemistry 2001 Jun 8;276(23):20559-65
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Supportive validation
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- Western Blot: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Lysates of Jurkat human acute T cell leukemia cell line untreated (-) or treated (+) with VP-16. PVDF membrane was probed with 0.1 ug/mL of mouse monoclonal Caspase-3 Antibody (31A1067) - (Pro and Active) (NB100-56708, Novus Biologicals) followed by 1:2000 dilution donkey anti-mouse IgG.
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- Western Blot: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Analysis using the Azide Free version of NB100-56708. Detection of Caspase-3 in multiple human tissues. The tissues shown are A) brain, B) heart, C) intestine, D) kidney, E) liver, F) lung, G) muscle, H) stomach, I) spleen, J) ovary, and K) testis.
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- Western Blot: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Analysis using the Azide Free version of NB100-56708. Detection of Lanes 1, 2 and 3 demonstrate the species cross-reactivity of the antibody in human, mouse and rat heart lysate, respectively.
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- Western Blot: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Analysis using Azide/BSA FREE version of NB100-56708. Analysis of Caspase-3 in A) RAW and B) NIH 3T3 using 32 ug/ml.
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- Western Blot: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Image of Caspase-3 Antibody (31A1067) - (Pro and Active). Whole cell protein from Jurkat cells treated with and without 2 uM staurosporine as indicated was separated on a 4-15% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 5 ug/ml anti-Caspase 3 in 1% milk, and detected with an anti-mouse HRP secondary antibody using a Femto sensitivity chemiluminescence reagent. Note the detection of both pro-caspase 3 at 35 kDa and the cleaved active caspase 3 at 15-17 kDa.
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- Western Blot: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Analysis using the Azide Free version of NB100-56708. Detection of Caspase-3 activation in HeLa cells. Cells were treated with 2mM staurosporine for different time periods. Caspase-3 activation is determined by cleavage of procaspase-3.
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- Simple Western: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Simple Western lane view shows a specific band for Caspase-3 Antibody (31A1067) - (Pro and Active) in 0.1 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230kDa separation system.
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- Western Blot: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Paclitaxel in combination with MWE retarded tumor growth in a human bladder carcinoma TSGH 8301 xenograft model. The levels of total (t-PTEN) and phospho-PTEN (p-PTEN) and Caspase 3 in the tumor specimens were determined by Western blotting and then quantified using beta-actin as the protein loading control; the results are expressed as a percentage of the control. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/srep20417), licensed under a CC-BY licence.
Supportive validation
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- Immunohistochemistry-Paraffin: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Analysis using the Azide Free version of NB100-56708. Staining of human breast cancer stained at 4ug/ml. Localization can be cytoplasmic and nuclear. Staining in the nucleus is considered to be an indication of active Caspase-3. In most cell types and model systems, cells with active Caspase-3 are undergoing apoptosis.
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- Immunohistochemistry-Paraffin: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Caspase-3 was detected in immersion fixed paraffin-embedded sections of human bladder tissue using 1:50 dilution of mouse aCaspase-3 Antibody (31A1067) - (Pro and Active) (NB100-56708), for 1 hour at room temperature followed by anti-mouse IgG VisUCyte HRP polymer(VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue).
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- Immunohistochemistry-Paraffin: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Analysis using the azide free version of NB100-56708. Staining of normal colon stained 4ug/ml. Localization can be cytoplasmic and nuclear. Staining in the nucleus is considered to be an indication of active Caspase-3. In most cell types and model systems
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- Immunohistochemistry-Paraffin: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Analysis using the Azide Free version of NB100-56708. Staining of the human thymus after heat-induced antigen retrieval at 5 ug/ml.
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- Immunohistochemistry-Paraffin: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Tissue section of human spleen using 1:200 dilution of Caspase-3 antibody (clone 31A1067). The staining was developed with HRP labeled anti-mouse IgG secondary antibody and DAB reagent, and nuclei of cells were counter-stained with hematoxylin. This Caspase 3 antibody generated primarily a specific cytoplasmic staining in a subset of spleenocytes with some nuclear signal in a few cells.
Supportive validation
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- Flow Cytometry: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - An intracellular stain was performed on HeLa cells with Caspase-3 Antibody (31A1067) - (Pro and Active) NB100-56708 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature, followed by mouse F(ab)2 IgG (H+L) APC-conjugated secondary antibody (F0101B, R&D Systems).
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- Flow Cytometry: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - An intracellular stain was performed on NIH3T3 cells with Caspase-3 Antibody (31A1067) - (Pro and Active) Antibody NB100-56708AF700 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 10 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 700.
