15967-1-AP

antibody from Proteintech Group

Targeting: PDIA3 ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC

Provider product page for 15967-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [38]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 15967-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15967-1-AP, RRID:AB_2236784
Product name: ERp57/ERp60 antibody
Antibody type: Polyclonal
Description: KD/KO validated ERp57/ERp60 antibody (Cat. #15967-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PDIA3 protein structure - 15967-1-AP shown in red.

Submitted references A facile and smart strategy to enhance bone regeneration with efficient vitamin D(3) delivery through sterosome technology.

Ye S, Wen J, Ye WH, Li Z, Huang X, Chen S, Ma JC, Wu Y, Chen R, Cui ZK
Journal of controlled release : official journal of the Controlled Release Society 2024 Jun;370:140-151

Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion.

Chen Z, Wang S, Pottekat A, Duffey A, Jang I, Chang BH, Cho J, Finck BN, Davidson NO, Kaufman RJ
Molecular metabolism 2024 Feb;80:101874

A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.

Zhang F, Liu C, Chen Z, Zhao C
Cell biology international 2024 Apr;48(4):541-550

Circ_005077 accelerates myocardial lipotoxicity induced by high-fat diet via CyPA/p47PHOX mediated ferroptosis.

Ni X, Duan L, Bao Y, Li J, Zhang X, Jia D, Wu N
Cardiovascular diabetology 2024 Apr 15;23(1):129

Significance of Immunogenic Cell Death-Related Prognostic Gene Signature in Cervical Cancer Prognosis and Anti-Tumor Immunity.

Jiang S, Cui Z, Zheng J, Wu Q, Yu H, You Y, Zheng C, Sun Y
Journal of inflammation research 2023;16:2189-2207

PDIA4 Is a Host Factor Important for Lymphocytic Choriomeningitis Virus Infection.

Xu M, Xu H, Wan W, Jian X, Jin R, Wang L, Wang J, Xiao G, Zhang L, Chen H, Wen Y
Viruses 2023 Nov 29;15(12)

Nutrient deprivation alters the rate of COPII coat assembly to tune secretory protein transport.

Kasberg W, Luong P, Swift KA, Audhya A
Research square 2023 Mar 17;

The role of PDIA3 in oral squamous cell carcinoma and its value as A diagnostic and prognostic biomarker.

Wang L, Wang X, Zhang J, Duan J, Tang C, Zhang L, Zeng H, Li H, Li Y, Zhou Y
Heliyon 2023 Dec;9(12):e22596

Nutrient deprivation alters the rate of COPII subunit recruitment at ER subdomains to tune secretory protein transport.

Kasberg W, Luong P, Swift KA, Audhya A
Nature communications 2023 Dec 8;14(1):8140

Vitamin D(3) Receptors and Metabolic Enzymes in Hen Reproductive Tissues.

Hrabia A, Kamińska K, Socha M, Grzesiak M
International journal of molecular sciences 2023 Dec 3;24(23)

BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.

Jin J, He Y, Guo J, Pan Q, Wei X, Xu C, Qi Z, Li Q, Ma S, Lin J, Jiang N, Ma J, Wang X, Jiang L, Ding Q, Osto E, Zhi X, Meng D
Nature communications 2023 Dec 21;14(1):8428

Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators.

Kline GM, Paxman RJ, Lin CY, Madrazo N, Yoon L, Grandjean JMD, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW
ACS chemical biology 2023 Aug 18;18(8):1719-1729

Protein Disulfide-Isomerase A3 Is a Robust Prognostic Biomarker for Cancers and Predicts the Immunotherapy Response Effectively.

Tu Z, Ouyang Q, Long X, Wu L, Li J, Zhu X, Huang K
Frontiers in immunology 2022;13:837512

Defective Human SRP Induces Protein Quality Control and Triggers Stress Response.

Tikhonova EB, Gutierrez Guarnizo SA, Kellogg MK, Karamyshev A, Dozmorov IM, Karamysheva ZN, Karamyshev AL
Journal of molecular biology 2022 Nov 30;434(22):167832

MicroRNA-mediated high expression of PDIA3 was correlated with poor prognosis of patients with LUAD.

Gu X, Li X, Zhang X, Feng R, Zheng M, Liu L, Yang J, Sun H, Zhang Q, Bian T, Zhao H, Liu Y
Genomics 2022 Jul;114(4):110417

Protein palmitoylation-mediated palmitic acid sensing causes blood-testis barrier damage via inducing ER stress.

Ge X, He Z, Cao C, Xue T, Jing J, Ma R, Zhao W, Liu L, Jueraitetibaike K, Ma J, Feng Y, Qian Z, Zou Z, Chen L, Fu C, Song N, Yao B
Redox biology 2022 Aug;54:102380

miRNA-mRNA Regulatory Network Reveals miRNAs in HCT116 in Response to Folic Acid Deficiency via Regulating Vital Genes of Endoplasmic Reticulum Stress Pathway.

Lu L, Zhao H, Liu J, Zhang Y, Wang X
BioMed research international 2021;2021:6650181

Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.

Sun J, Chen W, Li S, Yang S, Zhang Y, Hu X, Qiu H, Wu J, Xu S, Chu T
Frontiers in pharmacology 2021;12:751845

Vitamin D(3) in ovarian antral follicles of mature gilts: Expression of its receptors and metabolic enzymes, concentration in follicular fluid and effect on steroid secretion in vitro.

Grzesiak M, Knapczyk-Stwora K, Slomczynska M
Theriogenology 2021 Jan 15;160:151-160

Calnexin mediates the maturation of GPI-anchors through ER retention.

Guo XY, Liu YS, Gao XD, Kinoshita T, Fujita M
The Journal of biological chemistry 2020 Nov 27;295(48):16393-16410

Identification of PGAM1 as a putative therapeutic target for pancreatic ductal adenocarcinoma metastasis using quantitative proteomics.

Liu X, Weng Y, Liu P, Sui Z, Zhou L, Huang Y, Zhang L, Zhang Y, Tan X
OncoTargets and therapy 2018;11:3345-3357

Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes.

Jones JR, Kong L, Hanna MG 4th, Hoffman B, Krencik R, Bradley R, Hagemann T, Choi J, Doers M, Dubovis M, Sherafat MA, Bhattacharyya A, Kendziorski C, Audhya A, Messing A, Zhang SC
Cell reports 2018 Oct 23;25(4):947-958.e4

Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation.

Khodayari N, Marek G, Lu Y, Krotova K, Wang RL, Brantly M
Journal of cellular biochemistry 2017 Oct;118(10):3090-3101

Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis.

Liu Z, Wang Y, Wang Y, Dong W, Xia X, Song E, Song Y
Chemical research in toxicology 2017 Oct 16;30(10):1804-1814

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N
Oncotarget 2017 Nov 28;8(61):103543-103556

Combination of CALR and PDIA3 is a potential prognostic biomarker for non-small cell lung cancer.

Wang K, Li H, Chen R, Zhang Y, Sun XX, Huang W, Bian H, Chen ZN
Oncotarget 2017 Nov 14;8(57):96945-96957

Clock mediates liver senescence by controlling ER stress.

Yuan G, Hua B, Cai T, Xu L, Li E, Huang Y, Sun N, Yan Z, Lu C, Qian R
Aging 2017 Dec 22;9(12):2647-2665

The Circadian Gene Clock Regulates Bone Formation Via PDIA3.

Yuan G, Hua B, Yang Y, Xu L, Cai T, Sun N, Yan Z, Lu C, Qian R
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017 Apr;32(4):861-871

Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression.

Zhu Y, Cai L, Guo J, Chen N, Yi X, Zhao Y, Cai J, Wang Z
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):14009-14023

TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization.

Johnson A, Bhattacharya N, Hanna M, Pennington JG, Schuh AL, Wang L, Otegui MS, Stagg SM, Audhya A
The EMBO journal 2015 Mar 12;34(6):811-27

Proteome analysis of hepatic non-parenchymal cells of immune liver fibrosis rats.

Zhao Q, Feng Y, Jia X, Yin L, Zheng Y, Ouyang D, Zhou H, Zhang L
Science China. Life sciences 2014 Mar;57(3):303-314

MicroRNA directly enhances mitochondrial translation during muscle differentiation.

Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, Zhang H, Guo P, Sun H, Guo L, Zhang Y, Fu XD
Cell 2014 Jul 31;158(3):607-19

Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells.

Chen K, Huang C, Yuan J, Cheng H, Zhou R
Molecular biology and evolution 2014 Aug;31(8):2194-211

Proteomic analysis of the differences in orbital protein expression in thyroid orbitopathy.

Cheng KC, Huang HH, Hung CT, Chen CC, Wu WC, Suen JL, Chen KJ, Wu YJ, Chang CH
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2013 Dec;251(12):2777-87

Down-regulation of S100A11, a calcium-binding protein, in human endometrium may cause reproductive failure.

Liu XM, Ding GL, Jiang Y, Pan HJ, Zhang D, Wang TT, Zhang RJ, Shu J, Sheng JZ, Huang HF
The Journal of clinical endocrinology and metabolism 2012 Oct;97(10):3672-83

Proteomics changes in adhesion molecules: a driving force for vascular smooth muscle cell phenotypic switch.

Rocchiccioli S, Ucciferri N, Comelli L, Trivella MG, Citti L, Cecchettini A
Molecular bioSystems 2012 Apr;8(4):1052-9

Proteomic analysis of anti-tumor effects of 11-dehydrosinulariolide on CAL-27 cells.

Liu CI, Chen CC, Chen JC, Su JH, Huang HH, Chen JY, Wu YJ
Marine drugs 2011;9(7):1254-1272

An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.

Su CC, Su JH, Lin JJ, Chen CC, Hwang WI, Huang HH, Wu YJ
Marine drugs 2011 Dec;9(12):2622-2642

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: L02 cells were subjected to SDS PAGE followed by western blot with 15967-1-AP(PDIA3 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using PDIA3 antibody 15967-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 15967-1-AP(PDIA3 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 15967-1-AP(PDIA3 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue