FIP1L1

gene product
DKFZp586K0717, FIP1
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
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141 antibodies from 26 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Atlas Antibodies
2 antibodies
Novus Biologicals
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Biorbyt
4 antibodies
GeneTex
2 antibodies
NovoPro Bioscience Inc.
1 antibody
antibodies-online
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LifeSpan BioSciences, Inc.
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Invitrogen Antibodies
3 antibodies
Proteintech Group
1 antibody
Bethyl Laboratories
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Bioworld Technology, Inc
1 antibody
St John's Laboratory
1 antibody
Aviva Systems Biology
1 antibody
OriGene
1 antibody
Boster Biological Technology
1 antibody
Abnova Corporation
2 antibodies
RabMAbs
1 antibody
United States Biological
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MyBioSource
1 antibody
ProSci
1 antibody
Creative Biolabs
3 antibodies
Creative Diagnostics
2 antibodies
RayBiotech, Inc.
1 antibody
Sigma-Aldrich
2 antibodies
GenWay
1 antibody