14965-1-AP

antibody from Proteintech Group

Targeting: KRT19 CK19, K19, K1CS, MGC15366

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

14965-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#14965-1-AP, RRID:AB_2133324

Product name

Cytokeratin 19 antibody

Antibody type

Polyclonal

Description

KD/KO validated Cytokeratin 19 antibody (Cat. #14965-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

KRAS Inhibition Activates an Actionable CD24 "Don't Eat Me" Signal in Pancreatic Cancer.

Wei Y, Liu M, Yen EY, Yao J, Xun Z, Nguyen PT, Wang X, Yang Z, Yousef A, Pan D, Jin Y, Li CF, Theardy MS, Park J, Cai Y, Takeda M, Vasquez M, Park EM, Peng DH, Zhou Y, Zhao H, Heffernan TP, Viale A, Wang H, Watowich SS, Liang H, Zhao D, DePinho RA, Yao W, Ying H
bioRxiv : the preprint server for biology 2025 Sep 13;

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METTL3-Mediated m6A Modification Regulates the Polycomb Repressive Complex 1 Components BMI1 and RNF2 in Hepatocellular Carcinoma Cells.

Chen W, Zhang J, Ma W, Liu N, Wu T
Molecular cancer research : MCR 2025 Mar 3;23(3):190-201

---

ALKBH5 regulates intrauterine adhesion progression through m6A dependent FABP4 mRNA stabilization and serum lipid metabolism.

Yang X, Feng Q
Communications biology 2025 Jul 1;8(1):973

---

Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice.

Uno K, Uchino T, Suzuki T, Sayama Y, Edo N, Uno-Eder K, Morita K, Ishikawa T, Koizumi M, Honda H, Katagiri H, Tsukamoto K
PLoS biology 2025 Jan;23(1):e3002955

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WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer.

Citron F, Ho IL, Balestrieri C, Liu Z, Yen EN, Cecchetto L, Perelli L, Zhang L, Castillo Montanez LA, Blazanin N, Dyke CA, Shah R, Attanasio S, Srinivasan S, Chen KC, Chen Z, Scognamiglio I, Pham N, Khan H, Jiang S, Pan J, Vanderkruk B, Leung C, Mattohti M, Rai K, Chu Y, Wang L, Gao S, Deem AK, Carugo A, Wang H, Yao W, Tonon G, Xiong Y, Lorenzi PL, Bonini C, Zal A, Hoffman B, Giuliani V, Heffernan T, Jeter CR, Lissanu Y, Genovese G, Di Pilato M, Viale A, Draetta GF
bioRxiv : the preprint server for biology 2025 Jan 2;

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Exploratory study on the role of Clonorchis sinensis infection in promoting cholangiocarcinoma progression.

Li S, Jiang Y, Kawanokuchi J, Deng X, Wu Y, Chen Y, Zeng L, Deng G, Li D, Zhan T, Liu D, Ma N, Tang Z
Parasites & vectors 2025 Dec 9;19(1):29

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Emodin-Enhanced hUC-MSC extracellular vesicles alleviate acute pancreatitis by targeting inflammation and pyroptosis.

Liu X, Huang X, Huang X, Liu S, Hu J, Lin J
Stem cell research & therapy 2025 Aug 6;16(1):434

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Kynu inhibition mitigates bile duct ischemic injury by rewiring tryptophan metabolism to restore tight junction integrity.

Bao G, Zhang S, Ye Z, Luo D, Bi P, Yang B
Molecular medicine (Cambridge, Mass.) 2025 Aug 19;31(1):279

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Hepatobiliary organoids differentiated from hiPSCs relieve cholestasis-induced liver fibrosis in nonhuman primates.

Li H, Li J, Wang T, Sun K, Huang G, Cao Y, Wu F, Xu A
International journal of biological sciences 2024;20(4):1160-1179

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KRT19 is regulated by miR-642a-5p and promotes pancreatic cancer progression through the Wnt/β-catenin pathway.

Shi HQ, Li X, Chen Z, Dong S, Ye C, Hou S, Fan DA, Zhang H, Zhou WC
iScience 2024 Sep 20;27(9):110782

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Targeting PDGF-CC as a promising therapeutic strategy to inhibit cholangiocarcinoma progression.

Luo Z, Zhou F, Tan C, Yin L, Bao M, He X, Li H, Yan J
Journal of translational medicine 2024 Nov 14;22(1):1023

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Volumetric imaging reveals VEGF-C-dependent formation of hepatic lymph vessels in mice.

Bobe S, Beckmann D, Klump DM, Dierkes C, Kirschnick N, Redder E, Bauer N, Schäfers M, Erapaneedi R, Risse B, van de Pavert SA, Kiefer F
Frontiers in cell and developmental biology 2022;10:949896

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Targeted blocking of CCR2 and CXCR2 improves the efficacy of transarterial chemoembolization of hepatocarcinoma.

Tian Z, Hou X, Liu W, Shao C, Gao L, Jiang J, Zhang L, Han Z, Wei L
Cancer cell international 2022 Nov 19;22(1):362

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Multiscale and Multimodal Optical Imaging of the Ultrastructure of Human Liver Biopsies.

Kong C, Bobe S, Pilger C, Lachetta M, Øie CI, Kirschnick N, Mönkemöller V, Hübner W, Förster C, Schüttpelz M, Kiefer F, Huser T, Schulte Am Esch J
Frontiers in physiology 2021;12:637136

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The zonula occludens protein family regulates the hepatic barrier system in the murine liver.

Itoh M, Terada M, Sugimoto H
Biochimica et biophysica acta. Molecular basis of disease 2021 Jan 1;1867(1):165994

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ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice.

Fan W, Liu T, Chen W, Hammad S, Longerich T, Hausser I, Fu Y, Li N, He Y, Liu C, Zhang Y, Lian Q, Zhao X, Yan C, Li L, Yi C, Ling Z, Ma L, Zhao X, Xu H, Wang P, Cong M, You H, Liu Z, Wang Y, Chen J, Li D, Hui L, Dooley S, Hou J, Jia J, Sun B
Gastroenterology 2019 Nov;157(5):1352-1367.e13

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Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner.

Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH
American journal of physiology. Endocrinology and metabolism 2019 Jun 1;316(6):E1118-E1135

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Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.

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Nature 2019 Apr;568(7752):410-414

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Galunisertib modifies the liver fibrotic composition in the Abcb4Ko mouse model.

Hammad S, Cavalcanti E, Werle J, Caruso ML, Dropmann A, Ignazzi A, Ebert MP, Dooley S, Giannelli G
Archives of toxicology 2018 Jul;92(7):2297-2309

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Cholestasis-induced adaptive remodeling of interlobular bile ducts.

Vartak N, Damle-Vartak A, Richter B, Dirsch O, Dahmen U, Hammad S, Hengstler JG
Hepatology (Baltimore, Md.) 2016 Mar;63(3):951-64

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In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF
Cell reports 2016 Jun 28;16(1):133-147

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

MCF7 cells were subjected to SDS PAGE followed by western blot with 14965-1-AP(KRT19 antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using KRT19 antibody 14965-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human cervix using 14965-1-AP(KRT19 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human cervix using 14965-1-AP(KRT19 antibody) at dilution of 1:100 (under 40x lens)

Sample type

tissue