19124-1-AP

antibody from Proteintech Group

Targeting: TRPA1 ANKTM1

Provider product page for 19124-1-AP

Western blot

ELISA

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [39]
Comments [0]
Validations
Western blot [1]

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Product number: 19124-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19124-1-AP, RRID:AB_10642143
Product name: TRPA1 antibody
Antibody type: Polyclonal
Description: TRPA1 antibody (Cat. #19124-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TRPA1 protein structure - 19124-1-AP shown in red.

Submitted references Electroacupuncture reduces calcium influx and inhibits endoplasmic reticulum stress by inhibiting the PKCδ-TRPA1 pathway to promote motor function recovery after spinal cord injury.

Zhang Y, Liang C, Huang Z, Hu Y, Mo Y, Ning S, Li Z, Wu Y, Zhang J, Li X, Wang Z
Burns & trauma 2026;14:tkaf066

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses.

Chen J, Xie S, Lin Z, Zhao C, Tao R, Ma Y, Chen X, Wu R, Han Q, Sui P, Wang S, Ji H, Song H, Zhang X, Sun Y, Song Y, Su X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e07512

TRPA1 promotes overactive bladder progression by activating the NLRP3 inflammasome and driving pyroptosis.

Rao Y, Wang Y, Gao J, Guan X, Lv S, Gu J, Wang K
Cell death & disease 2026 Feb 16;17(1):226

Validation of TRPA1 and TRPV1 Antibodies for Expression Detection in Mammalian Cells and Tissues.

de Las Casas M, Hernández-Ortego P, Torres-Montero R, De la Peña E, Gomis A, Viana F, Fernández-Trillo J
Journal of neurochemistry 2026 Apr;170(4):e70444

Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases.

Zhou L, Yan M, Luo Q, Qiu W, Guo YR, Guo XQ, Yu HB, Huo JR, Feng YL, Wang DP, Sun T, Wang KF, Shi JY, Shang X, Wu MN, Wang L, Cao JM
Cellular and molecular gastroenterology and hepatology 2025;19(3):101439

The efficacy of ophiopogonanone B in treating the cough in mice infected with Mycoplasma pneumoniae.

Liu NN, Guo BH, Wang L, Wang XX, Wang X, Meng YL, Tang GX, Wang WM
Frontiers in pharmacology 2025;16:1397543

Transforming destructive mechanical cues into therapeutic power: Activation of PIEZO1 and TRPV4 counteracts mechano-induced damage of cellular junctions in Hailey-Hailey disease.

Hu J, Jia Y, Feng F, Zhao Q, Peng B, Wang X, Xiong H, Xu F, Geng S
Journal of advanced research 2025 Nov 26;

Transient receptor potential channels TRPA1 and TRPV1 are involved in chronic pain relief via Pulsed Radiofrequency in Rheumatoid Arthritis rat.

Wang YD, Xu Y, Zhu CM, Liu K, Zhao G, Hua H, Wang M, Li X
Neuropharmacology 2025 Nov 1;278:110548

IFT80 and TRPA1 cooperatively regulate bone formation by calcium signaling in response to mechanical stimuli.

Wang T, Chen Y, Zhu X, Zheng L, Li Y, Ruan X, Yan Z, Guan Z, Sun W, Wang H
Metabolism: clinical and experimental 2025 May;166:156159

Chenodeoxycholic acid activates the TGR5/TRPA1-5-HT pathway to regulate intestinal motility in breastfed infants and mouse models.

Shan Z, He C, Yang Q, Xiong J, Li M, Meng M, Huang Y
Translational pediatrics 2025 Jun 27;14(6):1213-1229

Bromelain Alleviates Sleep Deprivation-Induced Intestinal Injury via TRPA1/5-HT Axis.

Zhang HY, Li Y, Wang WH, Deng Y, Chen SY, Zheng ZJ, Ren H, Sun J
Journal of agricultural and food chemistry 2025 Jul 23;73(29):18153-18164

Yu-Xue-Bi capsule ameliorates aggressive synovitis and joint damage in rheumatoid arthritis via modulating the SUCNR1/HIF-1α/TRPV1 axis.

Chen W, Zhang C, Xu M, Li T, Li X, Li P, Gong X, Qu Y, Zhou C, Mao X, Lin N, Liu W, Jiang Q, Xu H, Zhang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156354

A novel technique of cryodenervation for murine vagus nerve: implications for acute lung inflammation.

Wu D, Liao X, Gao J, Wang K, Xu W, Wang F, Jin Z, Wu D, Li Q, Gao W
Respiratory research 2025 Jan 13;26(1):15

Ligustilide improves functional constipation by non-covalently activating TRPA1 in colon tissue.

Zhang K, Luan G, Liu W, Shen F, Jiang M, Bai G
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119018

Exploring the Analgesic Initiation Mechanism of Tuina in the Dorsal Root Ganglion of Minor CCI Rats via the TRPV1/TRPA1-cGMP Pathway.

Yang Z, Sa C, Yu T, Chen J, Zhang R, Zhang Y, Liu J, Zhang H, Sun J
Pain research & management 2024;2024:2437396

Protein phosphatase 2Cm-regulated branched-chain amino acid catabolic defect in dorsal root ganglion neurons drives pain sensitization.

Lian N, Li F, Zhou C, Yin Y, Kang Y, Luo K, Lui S, Li T, Lu P
Acta neuropathologica communications 2024 Sep 10;12(1):147

High humidity and NO(2) co-exposure exacerbates allergic asthma by increasing oxidative stress, inflammatory and TRP protein expressions in lung tissue.

Lu C, Liu Q, Qiao Z, Yang X, Baghani AN, Wang F
Environmental pollution (Barking, Essex : 1987) 2024 Jul 15;353:124127

Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury.

Zhang K, Liu W, Shen F, Luan G, Han Y, Xu J, Fu C, Wu W, Hou Y, Jiang M, Zhang T, Bai G
Journal of ethnopharmacology 2024 Aug 10;330:118217

Zhisou powder suppresses airway inflammation in LPS and CS-induced post-infectious cough model mice via TRPA1/TRPV1 channels.

Xu Y, Cao S, Wang SF, Ma W, Gou XJ
Journal of ethnopharmacology 2024 Apr 24;324:117741

Role of TRPV1 and TRPA1 in TSLP production in nasal epithelial cells.

Li J, Wang F, Meng C, Zhu D
International immunopharmacology 2024 Apr 20;131:111916

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes.

Lee HJ, Alirzayeva H, Koyuncu S, Rueber A, Noormohammadi A, Vilchez D
Nature aging 2023 May;3(5):546-566

Aconitine - A promising candidate for treating cold and mechanical allodynia in cancer induced bone pain.

Jin X, Cheng J, Zhang Q, Ji H, Zhu C, Yang Y, Zhou Y, Yu G, Wang C, Tang Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114284

L-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway.

Liao T, Mei W, Zhang L, Ding L, Yang N, Wang P, Zhang L
Journal of orthopaedic surgery and research 2023 May 26;18(1):386

Dissecting the effect of ileal faecal diversion on the intestine using single-cell sequencing.

Ma H, Li X, Pan Y, Wang L, Han B, Xie H, Zheng H, Jiang E, Chen J, Li Y, Ji G, Qiu Y, Xiao W
Clinical and translational medicine 2023 Jul;13(7):e1321

Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway.

Han Q, Gao X, Wang S, Wei Z, Wang Y, Xu K, Chen M
Toxicology letters 2023 Aug 1;384:73-85

Water extract of Notopterygium incisum alleviates cold allodynia in neuropathic pain by regulation of TRPA1.

Ruan Y, Jin X, Ji H, Zhu C, Yang Y, Zhou Y, Yu G, Wang C, Tang Z
Journal of ethnopharmacology 2023 Apr 6;305:116065

The Effectiveness of Wogonin on Treating Cough Mice With Mycoplasma Pneumoniae Infection.

Liang M, Meng Y, Wang X, Wang L, Tang G, Wang W
Frontiers in molecular biosciences 2022;9:803842

Pharmacogenetic inhibition of lumbosacral sensory neurons alleviates visceral hypersensitivity in a mouse model of chronic pelvic pain.

Xie AX, Iguchi N, Clarkson TC, Malykhina AP
PloS one 2022;17(1):e0262769

UVR Promotes Keratinocyte Phagocytosis and Skin Pigmentation Through TRPA1 Channels.

Liu Y, Li Z, Wu W, Wang Y, Zhao G, Liu Y, Liu J, Song Z
Clinical, cosmetic and investigational dermatology 2022;15:1183-1193

Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.

Sun W, Wen M, Liu M, Wang Q, Liu Q, Li L, Siebert HC, Loers G, Zhang R, Zhang N
Frontiers in aging neuroscience 2022;14:1075161

Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK/AKT Signaling Pathway.

Yang XJ, Ling S, Zhou ML, Deng HJ, Qi M, Liu XL, Zhen C, Chen YX, Fan XR, Wu ZY, Ma FC, Rong J, Di GF, Jiang XC
Neuroscience 2022 Jul 1;494:51-68

Yanghe decoction attenuated pain hypersensitivity induced by michigan cancer foundation-7 injection in rats with bone metastases from breast cancer by inhibiting transient receptor potential ankyrin 1.

Hui G, Yang LI, Lei F, Yujie X, Lizhong H, Dan M, Hui Z
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Dec;42(6):948-955

Functional expression of TRPA1 channel, TRPV1 channel and TMEM100 in human odontoblasts.

Liu Y, Wang Y, Lou Y, Tian W, Que K
Journal of molecular histology 2021 Oct;52(5):1105-1114

Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts.

Lowin T, Tingting R, Zurmahr J, Classen T, Schneider M, Pongratz G
Cell death & disease 2020 Sep 1;11(8):714

Propofol exerts neuroprotective functions by down-regulating microRNA-19a in glutamic acid-induced PC12 cells.

Yu S, Xin W, Jiang Q, Li A
BioFactors (Oxford, England) 2020 Nov;46(6):934-942

Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro.

Suzuki N, Tsugami Y, Wakasa H, Suzuki T, Nishimura T, Kobayashi K
Molecular nutrition & food research 2020 Nov 14;:e2000853

A dual receptors-targeting and size-switchable "cluster bomb" co-loading chemotherapeutic and transient receptor potential ankyrin 1 (TRPA-1) inhibitor for treatment of triple negative breast cancer.

Wang Y, Yin S, Mei L, Yang Y, Xu S, He X, Wang M, Li M, Zhang Z, He Q
Journal of controlled release : official journal of the Controlled Release Society 2020 May 10;321:71-83

Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury.

Liu Z, Wang P, Lu S, Guo R, Gao W, Tong H, Yin Y, Han X, Liu T, Chen X, Zhu MX, Yang Z
Cell calcium 2020 Jun;88:102198

Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice.

Zhou Y, Han D, Follansbee T, Wu X, Yu S, Wang B, Shi Z, Domocos DT, Carstens M, Carstens E, Hwang ST
Journal of cellular and molecular medicine 2019 Jul;23(7):4819-4828

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TRPA1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human TRPA1. This antibody recognizes human antigen. The TRPA1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 19124-1-AP.pdf

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