10105-2-AP

antibody from Proteintech Group

Targeting: UBE2T FANCT, HSPC150

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Antibody Data

Product number

10105-2-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10105-2-AP, RRID:AB_2211478

Product name

UBE2T/HSPC150 antibody

Antibody type

Polyclonal

Description

KD/KO validated UBE2T/HSPC150 antibody (Cat. #10105-2-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IP, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Fanconi anemia pathway regulation by FANCI in prostate cancer.

Kaljunen H, Taavitsainen S, Kaarijärvi R, Takala E, Paakinaho V, Nykter M, Bova GS, Ketola K
Frontiers in oncology 2023;13:1260826

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Targeting UBE2T Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Regulating Pyrimidine Metabolism and Replication Stress.

Jiang X, Ma Y, Wang T, Zhou H, Wang K, Shi W, Qin L, Guan J, Li L, Long B, Wang J, Guan X, Ye H, Yang J, Yu Z, Jiao Z
Gastroenterology 2023 Jun;164(7):1232-1247

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UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6.

Tao X, Wu X, Zhou P, Yu X, Zhao C, Peng X, Zhang K, Shen L, Peng J, Yang L
Cancer science 2023 Feb;114(2):521-532

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UBE2T regulates epithelial-mesenchymal transition through the PI3K-AKT pathway and plays a carcinogenic role in ovarian cancer.

Cui P, Li H, Wang C, Liu Y, Zhang M, Yin Y, Sun Z, Wang Y, Chen X
Journal of ovarian research 2022 Sep 10;15(1):103

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ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis.

Xiao Y, Deng Z, Li Y, Wei B, Chen X, Zhao Z, Xiu Y, Hu M, Alahdal M, Deng Z, Wang D, Liu J, Li W
Cancer cell international 2022 May 16;22(1):193

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miR-498 Targets UBE2T to Inhibit the Proliferation of Malignant Melanoma Cells.

Cao W, Ni L, Li P, Wang QX, Li MM, Huang SH, Dang NN
Technology in cancer research & treatment 2022 Jan-Dec;21:15330338221082431

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Comprehensive analysis of differentially expressed genes reveals the promotive effects of UBE2T on colorectal cancer cell proliferation.

Luo M, Zhou Y
Oncology letters 2021 Oct;22(4):714

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Increased Expression of UBE2T Predicting Poor Survival of Epithelial Ovarian Cancer: Based on Comprehensive Analysis of UBE2s, Clinical Samples, and the GEO Database.

Zou R, Xu H, Li F, Wang S, Zhu L
DNA and cell biology 2021 Jan;40(1):36-60

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Affinity-based protein profiling to reveal targets of puerarin involved in its protective effect on cardiomyocytes.

Huang S, Wang FJ, Lin H, Liu T, Zhao CX, Chen LG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Feb;134:111160

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UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.

Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222

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Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications.

Wu X, Liu G, Liu R, He J, Wang G, Zhang H, Liu T, Bai J, Cheng N, Qiu J
Oncology letters 2020 Nov;20(5):275

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UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma.

Liu LL, Zhu JM, Yu XN, Zhu HR, Shi X, Bilegsaikhan E, Guo HY, Wu J, Shen XZ
Cancer management and research 2019;11:8359-8370

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A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity.

Vila IK, Park MK, Setijono SR, Yao Y, Kim H, Badin PM, Choi S, Narkar V, Choi SW, Chung J, Moro C, Song SJ, Song MS
JCI insight 2019 Jul 11;4(13)

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Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma.

Alagpulinsa DA, Kumar S, Talluri S, Nanjappa P, Buon L, Chakraborty C, Samur MK, Szalat R, Shammas MA, Munshi NC
Blood advances 2019 Dec 10;3(23):3968-3972

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Ubiquitin-Conjugating Enzyme E2T is an Independent Prognostic Factor and Promotes Gastric Cancer Progression.

Yu H, Xiang P, Pan Q, Huang Y, Xie N, Zhu W
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Sep;37(9):11723-11732

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UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3β/β-catenin pathway.

Hu W, Xiao L, Cao C, Hua S, Wu D
Oncotarget 2016 Mar 22;7(12):15161-72

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Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.

Hira A, Yoshida K, Sato K, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Shimamoto A, Tahara H, Ito E, Kojima S, Kurumizaka H, Ogawa S, Takata M, Yabe H, Yabe M
American journal of human genetics 2015 Jun 4;96(6):1001-7

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Elevated expression of UBE2T in lung cancer tumors and cell lines.

Hao J, Xu A, Xie X, Hao J, Tian T, Gao S, Xiao X, He D
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2008;29(3):195-203

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Proteasome function is required for DNA damage response and fanconi anemia pathway activation.

Jacquemont C, Taniguchi T
Cancer research 2007 Aug 1;67(15):7395-405

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Jurkat cells were subjected to SDS PAGE followed by western blot with 10105-2-AP(UBE2T antibody) at dilution of 1:800

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using UBE2T antibody 10105-2-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

Sample type

cell line