11741-1-AP

antibody from Proteintech Group

Targeting: TPX2 C20orf1, C20orf2, DIL-2, p100

Provider product page for 11741-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 11741-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11741-1-AP, RRID:AB_2208895
Product name: TPX2 antibody
Antibody type: Polyclonal
Description: KD/KO validated TPX2 antibody (Cat. #11741-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TPX2 protein structure - 11741-1-AP shown in red.

Submitted references Integrating multiple key molecules in uveal melanoma to uncover metastatic and immune microenvironment-related gene signatures.

Guo YM, Bai ZP, Wang JQ, Huang J, Wei JH, Han YJ, Liu Y, Ye L
International journal of ophthalmology 2026;19(1):11-24

Targeting TPX2-dependent lineage plasticity by CDK4/6 inhibition reverses therapy resistance in neuroendocrine bladder carcinoma.

Chen Z, Peng S, Fu S, Lin S, Su Y, He X, Zhang Y, Lu J, Liu S, Zhan H, Zhong J, Ye B, Zhang C, Liu C, Pan B, Dong H, Li H, Ye X, Wang J, Chen S, He B, Wu J, Li H, Zhang Q, Wang H, Chen X
Cell reports. Medicine 2026 Apr 21;7(4):102712

Tubacin alleviate the reproductive toxicity of deoxynivalenol in mouse oocytes and zygotes via strengthening microtubule stability.

Luo H, Chen J, Guo Z, Zhu Y, Wang Y, Wu T, Yin S, Li C, Su Y, Chen Y, Qian Y, Miao C, Feng R
Cell communication and signaling : CCS 2025 Oct 3;23(1):417

Integrated transcriptomic and immunoinformatics analysis identifies tpx2, bub1b, and ube2c as diagnostic biomarkers and therapeutic targets in endometrial carcinoma.

Zhou S, Sun J, Li J, Zhou X, Shi X, Yang M, Wang Y, Zhang J
Discover oncology 2025 Oct 27;16(1):1975

CUDC-907 exerts an inhibitory effect on non-small cell lung cancer associated with induction of mitotic catastrophe and downregulation of YAP/TAZ signaling.

Liu Y, Qi X, Luo XP, Wang YF, Wan JJ, Wang FZ, Zhang WY
Chemico-biological interactions 2025 Nov 1;421:111735

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging.

Pan ZN, Zhang HL, Zhang KH, Ju JQ, Liu JC, Sun SC
Science China. Life sciences 2025 Mar;68(3):764-776

The RNA-stability-independent role of the RNA m(6)A reader YTHDF2 in promoting protein translation to confer tumor chemotherapy resistance.

Liu T, Yang D, Wei Q, Wang Y, Tian L, Liu X, Yang Y, Luo Q, Xu J, Liu Y, Yang C, Zuo X, Luo F, Luo X, Zhao H, Li L, Xu J, Yu J, Ma S, Yu J, Yi P
Molecular cell 2025 Jun 19;85(12):2320-2336.e9

Kinesin KIF16B Participates in G2/M Transition and Microtubule Dynamics via Aurora A-PLK1 in Oocyte Meiosis.

Li MX, Zhang KH, Zou YJ, Lu PS, Sun SC, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70854

Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like "band-tightening spell".

Guo JN, Zhu L, Meng TG, Zhang YN, Sun SM, Yang XM, Zhao BW, Lu YK, Xu YH, Yue W, Han Z, Wong CCL, Wang ZB
Cellular and molecular life sciences : CMLS 2025 Jul 30;82(1):292

Unravelling TPX2-centered co-expression networks as key drivers of aggressive prostate cancer.

Sheibani-Tezerji R, Perez Malla CU, Wasinger G, Misura K, Haase A, Malzer A, Kalla J, Tran L, Egger G
Scientific reports 2025 Dec 16;15(1):43908

Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis.

Vial Y, Nardelli J, Bonnard AA, Rousselot J, Souyri M, Gressens P, Cavé H, Drunat S
EMBO reports 2024 May;25(5):2418-2440

High TPX2 expression results in poor prognosis, and Sp1 mediates the coupling of the CX3CR1/CXCL10 chemokine pathway to the PI3K/Akt pathway through targeted inhibition of TPX2 in endometrial cancer.

Yang M, Mao X, Li L, Yang J, Xing H, Jiang C
Cancer medicine 2024 Mar;13(5):e6958

Arf1 GTPase Regulates Golgi-Dependent G2/M Transition and Spindle Organization in Oocyte Meiosis.

Zhang KH, Zou YJ, Shan MM, Pan ZN, Ju JQ, Liu JC, Ji YM, Sun SC
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(4):e2303009

Novel Signaling Pathway and NSC689534 as a Potential Drug Candidate for Cutaneous Squamous Cell Carcinoma.

Miao Y, Shen C, Zhang X, Li QQ, Pang AY, Zhao WM, Wu XY, Qian HY, Chen XD
Frontiers in bioscience (Landmark edition) 2024 Jan 17;29(1):19

CtIP regulates G2/M transition and bipolar spindle assembly during mouse oocyte meiosis.

Yue W, Zhang HY, Schatten H, Meng TG, Sun QY
Journal of genetics and genomics = Yi chuan xue bao 2024 Dec;51(12):1435-1446

Reversal of the tamoxifen‑resistant breast cancer malignant phenotype by proliferation inhibition with bromosulfonamidine amino‑podophyllotoxin.

Wang J, Lv F, Zhu Y, Lu X, Zhang B
Oncology letters 2024 Aug;28(2):373

Transmission of Exosomal TPX2 Promotes Metastasis and Resistance of NSCLC Cells to Docetaxel.

Hu J, He Q, Tian T, Chang N, Qian L
OncoTargets and therapy 2023;16:197-210

miR-29c Suppresses the Malignant Phenotype of Hepatocellular Carcinoma Cells In Vitro by Mediating TPX2 Associated with Immune Infiltration.

Wang H, Chen W, Qi Y, Liu D, Liu Z, Zhang Q, Yi Y, Wang J, Wu W
Digestive diseases and sciences 2023 May;68(5):1923-1935

Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.

Ju JQ, Pan ZN, Zhang KH, Ji YM, Liu JC, Sun SC
EMBO reports 2023 May 4;24(5):e56273

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.

Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7

Augmin-dependent microtubule self-organization drives kinetochore fiber maturation in mammals.

Almeida AC, Soares-de-Oliveira J, Drpic D, Cheeseman LP, Damas J, Lewin HA, Larkin DM, Aguiar P, Pereira AJ, Maiato H
Cell reports 2022 Apr 5;39(1):110610

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

Wang H, Feng K, Wang Q, Deng H
Scientific reports 2021 Jul 9;11(1):14253

Importin α phosphorylation promotes TPX2 activation by GM130 to control astral microtubules and spindle orientation.

Guo H, Wei JH, Zhang Y, Seemann J
Journal of cell science 2021 Feb 19;134(4)

WDR62 regulates spindle dynamics as an adaptor protein between TPX2/Aurora A and katanin.

Huang J, Liang Z, Guan C, Hua S, Jiang K
The Journal of cell biology 2021 Aug 2;220(8)

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.

Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
bioRxiv : the preprint server for biology 2020 Nov 16;

CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment.

Zhou H, Zheng T, Wang T, Li Q, Wang F, Liang X, Chen J, Teng J
BMC biology 2019 Sep 14;17(1):73

Dysfunction of Sister Chromatids Separation Promotes Progression of Hepatocellular Carcinoma According to Analysis of Gene Expression Profiling.

Sun B, Lin G, Ji D, Li S, Chi G, Jin X
Frontiers in physiology 2018;9:1019

Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.

Yang J, Gao F, Xu X, Wang Y, Zhu S
Clinical and experimental pharmacology & physiology 2017 Oct;44(10):1060-1068

Expression of microtubule-associated protein TPX2 in human gastric carcinoma and its prognostic significance.

Shao C, Duan C, Wang J, Luan S, Gao Y, Jin D, Wang D, Li Y, Xu L
Cancer cell international 2016;16:79

Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility.

Hu MW, Wang ZB, Teng Y, Jiang ZZ, Ma XS, Hou N, Cheng X, Schatten H, Xu X, Yang X, Sun QY
Journal of cell science 2015 Oct 15;128(20):3769-80

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11741-1-AP(TPX2 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using TPX2 antibody 11741-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line