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- Antibody Data
- Antigen structure
- References [12]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 11833-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11833-1-AP, RRID:AB_2180795
- Product name
- RSAD2 antibody
- Antibody type
- Polyclonal
- Description
- RSAD2 antibody (Cat. #11833-1-AP) is a rabbit polyclonal antibody that shows reactivity with mouse, human, rat and has been validated for the following applications: ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection.
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Purification of the full-length, membrane-associated form of the antiviral enzyme viperin utilizing nanodiscs.
The antiviral enzyme viperin inhibits cholesterol biosynthesis.
Viperin, through its radical-SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication.
Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex.
Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.
Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression.
MiR-23a facilitates the replication of HSV-1 through the suppression of interferon regulatory factor 1.
Azithromycin induces anti-viral responses in bronchial epithelial cells.
Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene.
Hardy A, Bakshi S, Furnon W, MacLean O, Gu Q, Varjak M, Varela M, Aziz MA, Shaw AE, Pinto RM, Cameron Ruiz N, Mullan C, Taggart AE, Da Silva Filipe A, Randall RE, Wilson SJ, Stewart ME, Palmarini M
mBio 2023 Jun 27;14(3):e0010123
mBio 2023 Jun 27;14(3):e0010123
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Purification of the full-length, membrane-associated form of the antiviral enzyme viperin utilizing nanodiscs.
Patel AM, Koebke KJ, Grunkemeyer TJ, Riordan CM, Kim Y, Bailey RC, Marsh ENG
Scientific reports 2022 Jul 13;12(1):11909
Scientific reports 2022 Jul 13;12(1):11909
The antiviral enzyme viperin inhibits cholesterol biosynthesis.
Grunkemeyer TJ, Ghosh S, Patel AM, Sajja K, Windak J, Basrur V, Kim Y, Nesvizhskii AI, Kennedy RT, Marsh ENG
The Journal of biological chemistry 2021 Jul;297(1):100824
The Journal of biological chemistry 2021 Jul;297(1):100824
Viperin, through its radical-SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication.
Ebrahimi KH, Howie D, Rowbotham JS, McCullagh J, Armstrong FA, James WS
FEBS letters 2020 May;594(10):1624-1630
FEBS letters 2020 May;594(10):1624-1630
Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex.
Dumbrepatil AB, Zegalia KA, Sajja K, Kennedy RT, Marsh ENG
The Journal of biological chemistry 2020 Feb 28;295(9):2839-2849
The Journal of biological chemistry 2020 Feb 28;295(9):2839-2849
Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.
Dumbrepatil AB, Ghosh S, Zegalia KA, Malec PA, Hoff JD, Kennedy RT, Marsh ENG
The Journal of biological chemistry 2019 Apr 26;294(17):6888-6898
The Journal of biological chemistry 2019 Apr 26;294(17):6888-6898
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.
Torres-Odio S, Key J, Hoepken HH, Canet-Pons J, Valek L, Roller B, Walter M, Morales-Gordo B, Meierhofer D, Harter PN, Mittelbronn M, Tegeder I, Gispert S, Auburger G
Journal of neuroinflammation 2017 Aug 2;14(1):154
Journal of neuroinflammation 2017 Aug 2;14(1):154
Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression.
Lubick KJ, Robertson SJ, McNally KL, Freedman BA, Rasmussen AL, Taylor RT, Walts AD, Tsuruda S, Sakai M, Ishizuka M, Boer EF, Foster EC, Chiramel AI, Addison CB, Green R, Kastner DL, Katze MG, Holland SM, Forlino A, Freeman AF, Boehm M, Yoshii K, Best SM
Cell host & microbe 2015 Jul 8;18(1):61-74
Cell host & microbe 2015 Jul 8;18(1):61-74
MiR-23a facilitates the replication of HSV-1 through the suppression of interferon regulatory factor 1.
Ru J, Sun H, Fan H, Wang C, Li Y, Liu M, Tang H
PloS one 2014;9(12):e114021
PloS one 2014;9(12):e114021
Azithromycin induces anti-viral responses in bronchial epithelial cells.
Gielen V, Johnston SL, Edwards MR
The European respiratory journal 2010 Sep;36(3):646-54
The European respiratory journal 2010 Sep;36(3):646-54
Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene.
Schmeisser H, Mejido J, Balinsky CA, Morrow AN, Clark CR, Zhao T, Zoon KC
Journal of virology 2010 Oct;84(20):10671-80
Journal of virology 2010 Oct;84(20):10671-80
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 11833-1-AP(RSAD2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using RSAD2 antibody 11833-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin using 11833-1-AP(RSAD2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin using 11833-1-AP(RSAD2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
