Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7917 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- POLK polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human POLK.
- Description
- Problems in DNA replication may lead to breaks in the replication fork, and recombinational reactions occur to restore the integrity of the fork via strand-invasion of the broken chromosome with its homologous strand. If this happens within repeated DNA sequences, genetic rearrangements may be produced. The bacterial UmuC/DinB family consists of bypass polymerases that are responsible for translesion DNA synthesis. DinB, also referred to as DNA polyermase IV or DNA polymerase k, is an SOS-inducible, error-prone DNA polymerase that plays a role in DNA damage-induced mutagenesis by preferentially making frameshift mutations. DinB is uniquely and highly expressed in the adrenal cortex and testis, as well as in a variety of other tissues. p53 regulates DinB and exposure to various DNA-damaging agents causes an upregulation of DinB.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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