19929-1-AP

antibody from Proteintech Group

Targeting: HEY1 bHLHb31, CHF-2, CHF2, HERP2, HESR-1, HESR1, HRT-1

Provider product page for 19929-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [49]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 19929-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19929-1-AP, RRID:AB_10646438
Product name: HEY1 antibody
Antibody type: Polyclonal
Description: KD/KO validated HEY1 antibody (Cat. #19929-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HEY1 protein structure - 19929-1-AP shown in red.

Submitted references Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1.

Ma W, Zhang L, Chen W, Chang Z, Tu J, Qin Y, Yao Y, Dong M, Ding J, Li S, Li F, Deng Q, Yang Y, Feng T, Zhang F, Shao X, He X, Zhang L, Hu G, Liu Q, Jiang YZ, Zhu S, Xiao Z, Su D, Liu T, Liu S
Protein & cell 2024 May 28;15(6):419-440

Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas.

Nakashoji A, Haratake N, Bhattacharya A, Mao W, Xu K, Wang K, Daimon T, Ozawa H, Shigeta K, Fushimi A, Yamashita N, Morimoto Y, Shimokawa M, Saito S, Egloff AM, Uppaluri R, Long MD, Kufe D
Cancer research communications 2024 May 14;4(5):1268-1281

Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1.

Herrera JL, Komatsu M
Cell reports 2024 Mar 26;43(3):113837

Androgens and Notch signaling cooperate in seminiferous epithelium to regulate genes related to germ cell development and apoptosis.

Kamińska A, Lustofin S, Brzoskwinia M, Duliban M, Cyran-Gryboś J, Bilińska B, Hejmej A
Reproductive biology 2024 Jun;24(2):100878

LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo.

Xu Y, Qiu Z, Chen J, Huang L, Zhang J, Lin J
Drug delivery and translational research 2024 Jul;14(7):2003-2018

Spindle and kinetochore-related complex subunit 3 has a protumour function in osteosarcoma by activating the Notch pathway.

Liang G, Duan C, He J, Shi L
Toxicology and applied pharmacology 2024 Feb;483:116826

Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer.

Jiang Y, Wang Y, Chen G, Sun F, Wu Q, Huang Q, Zeng D, Qiu W, Wang J, Yao Z, Liang B, Li S, Wu J, Huang N, Wang Y, Chen J, Zhai X, Huang L, Xu B, Yamamoto M, Tsukamoto T, Nomura S, Liao W, Shi M
Cell metabolism 2024 Aug 6;36(8):1806-1822.e11

The bone-protective benefits of kaempferol combined with metformin by regulation of osteogenesis-angiogenesis coupling in OVX rats.

Zhang Z, Xu W, Zhang Z, Chen X, Jin H, Jiang N, Xu H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116364

APEX1 predicts poor prognosis of gallbladder cancer and affects biological properties of CD133(+) GBC-SD cells via upregulating Jagged1.

Wu Z, Liu Z, Sun Y, Yuan Y, Zou Q, Wen Y, Luo J, Liu R
Journal of Cancer 2023;14(8):1443-1457

A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth.

Saran U, Chandrasekaran B, Tyagi A, Shukla V, Singh A, Sharma AK, Damodaran C
Frontiers in pharmacology 2023;14:1150774

The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke.

Zhang Y, Zhao X, Guo C, Zhang Y, Zeng F, Yin Q, Li Z, Shao L, Zhou D, Liu L
Neuroscience bulletin 2023 Sep;39(9):1375-1395

KLF9 Promotes Osteogenic Differentiation of Dental Stem Cells by Negatively Regulating Notch1 Mediated Signaling Pathway.

Zhao X, Mai Z, Lu Y, Cui L, Yu J
Frontiers in bioscience (Landmark edition) 2023 May 6;28(5):85

PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway.

Zhang R, Dong M, Tu J, Li F, Deng Q, Xu J, He X, Ding J, Xia J, Sheng D, Chang Z, Ma W, Dong H, Zhang Y, Zhang L, Zhang L, Liu S
Signal transduction and targeted therapy 2023 Mar 1;8(1):97

Exploring the potential of ginseng glycoprotein to improve learning and memory in mice via Notch signaling pathway and structural analysis using multi-information fusion based on liquid chromatography-mass spectrometry.

Fang X, Zhang X, Zhang Y, Zhang X, Shan M, Guan S, Qiu Z, Zhu D, Luo H
Journal of ethnopharmacology 2023 Mar 1;303:115978

Notch mediates the glycolytic switch via PI3K/Akt signaling to support embryonic development.

Wang H, Liang W, Wang X, Zhan Y, Wang W, Yang L, Zhu Y
Cellular & molecular biology letters 2023 Jun 26;28(1):50

ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.

Cui L, Lu Y, Zheng J, Guo B, Zhao X
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335

Babam2 negatively regulates osteoclastogenesis by interacting with Hey1 to inhibit Nfatc1 transcription.

Jin F, Zhu Y, Liu M, Wang R, Cui Y, Wu Y, Liu G, Wang Y, Wang X, Ren Z
International journal of biological sciences 2022;18(11):4482-4496

Exosome-mediated delivery of RBP-J decoy oligodeoxynucleotides ameliorates hepatic fibrosis in mice.

He F, Li WN, Li XX, Yue KY, Duan JL, Ruan B, Liu JJ, Song P, Yue ZS, Tao KS, Wang L
Theranostics 2022;12(4):1816-1828

BRD7 restrains TNF-α-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.

Li H, Yang T, Chen T, Liu Y, Pang Y, Yang L
Experimental lung research 2022 Sep-Oct;48(7-8):199-212

Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.

Liao Z, Ke W, Liu H, Tong B, Wang K, Feng X, Hua W, Wang B, Song Y, Luo R, Liang H, Zhang W, Zhao K, Li S, Yang C
Journal of nanobiotechnology 2022 Sep 19;20(1):420

Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell Function and Alleviates Ischemic Stroke by Upregulating NOTCH3.

Zhu T, Chen H, He C, Liu X
Neurochemical research 2022 May;47(5):1442-1458

Notch pathway inhibition mediated by arsenic trioxide depletes tumor initiating cells in small cell lung cancer.

Yang MH, Li B, Chang KJ
Molecular biology reports 2022 Mar;49(3):2245-2253

Zhang L, Zhang S, Chen F
Experimental and therapeutic medicine 2022 Jul;24(1):476

Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells.

Ojha R, Tantray I, Rimal S, Mitra S, Cheshier S, Lu B
Developmental cell 2022 Jan 24;57(2):260-276.e9

Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer.

Webster ALH, Sanders MA, Patel K, Dietrich R, Noonan RJ, Lach FP, White RR, Goldfarb A, Hadi K, Edwards MM, Donovan FX, Hoogenboezem RM, Jung M, Sridhar S, Wiley TF, Fedrigo O, Tian H, Rosiene J, Heineman T, Kennedy JA, Bean L, Rosti RO, Tryon R, Gonzalez AM, Rosenberg A, Luo JD, Carroll TS, Shroff S, Beaumont M, Velleuer E, Rastatter JC, Wells SI, Surrallés J, Bagby G, MacMillan ML, Wagner JE, Cancio M, Boulad F, Scognamiglio T, Vaughan R, Beaumont KG, Koren A, Imielinski M, Chandrasekharappa SC, Auerbach AD, Singh B, Kutler DI, Campbell PJ, Smogorzewska A
Nature 2022 Dec;612(7940):495-502

Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells.

Cheng L, Xie M, Qiao W, Song Y, Zhang Y, Geng Y, Xu W, Wang L, Wang Z, Huang K, Dong N, Sun Y
Communications biology 2021 Sep 6;4(1):1039

Obesity Impairs Embryonic Myogenesis by Enhancing BMP Signaling within the Dermomyotome.

Zhao L, Law NC, Gomez NA, Son J, Gao Y, Liu X, de Avila JM, Zhu MJ, Du M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2102157

hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.

Wan X, Zhu L, Zhao L, Peng L, Xiong J, Yang W, Yuan J, Liang F, Zhang K, Chen K
Cell death & disease 2021 Mar 19;12(4):301

Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma.

Fukusumi T, Guo TW, Ren S, Haft S, Liu C, Sakai A, Ando M, Saito Y, Sadat S, Califano JA
International journal of oncology 2021 Feb;58(2):226-237

Reduced expression of ppGalNAc-T4 promotes proliferation of human breast cancer cells.

Wu Q, Xie X, Zhang K, Niang B, Liu Y, Zhang C, Huang T, Huang H, Li W, Zhang J, Liu Y
Cell biology international 2021 Feb;45(2):320-333

ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway.

Wu Y, Chen X, Dong W, Xu Z, Jian Y, Xu C, Zhang L, Wei A, Yu X, Wang S, Wang Y, Liu G, Sun X, Wang S
Frontiers in oncology 2020;10:540332

Notch1 signaling mediated dysfunction of bone marrow mesenchymal stem cells derived from cyanotic congenital heart disease.

Wang T, Xing J, Ying Y, Tang H, Li J, Wei Y, Zhang H
Biochemical and biophysical research communications 2020 Jul 5;527(4):847-853

A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma.

Wei Y, Chen X, Liang C, Ling Y, Yang X, Ye X, Zhang H, Yang P, Cui X, Ren Y, Xin X, Li H, Wang R, Wang W, Jiang F, Liu S, Ding J, Zhang B, Li L, Wang H
Hepatology (Baltimore, Md.) 2020 Jan;71(1):130-147

miR-214-5p suppresses the proliferation, migration and invasion of trophoblast cells in pre-eclampsia by targeting jagged 1 to inhibit notch signaling pathway.

Gong F, Chai W, Wang J, Cheng H, Shi Y, Cui L, Jia G
Acta histochemica 2020 Apr;122(3):151527

JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix.

Long J, Wang X, Du X, Pan H, Wang J, Li Z, Liu H, Li X, Zheng Z
Arthritis research & therapy 2019 Oct 16;21(1):213

Salidroside suppresses the metastasis of hepatocellular carcinoma cells by inhibiting the activation of the Notch1 signaling pathway.

Lu L, Liu S, Dong Q, Xin Y
Molecular medicine reports 2019 Jun;19(6):4964-4972

Undifferentiated spermatogonia regulate Cyp26b1 expression through NOTCH signaling and drive germ cell differentiation.

Parekh PA, Garcia TX, Waheeb R, Jain V, Gandhi P, Meistrich ML, Shetty G, Hofmann MC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8423-8435

MicroRNA-34a attenuates VEGF-mediated retinal angiogenesis via targeting Notch1.

Shi S, Jin Y, Song H, Chen X
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Aug;97(4):423-430

Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.

Yuan Q, Chen X, Han Y, Lei T, Wu Q, Yu X, Wang L, Fan Z, Wang S
International journal of cancer 2018 Nov 1;143(9):2319-2330

MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.

Lei CT, Tang H, Ye C, You CQ, Zhang J, Zhang CY, Xiong W, Su H, Zhang C
Scientific reports 2017 Sep 4;7(1):10393

miR-150 enhances apoptotic and anti-tumor effects of paclitaxel in paclitaxel-resistant ovarian cancer cells by targeting Notch3.

Kim TH, Jeong JY, Park JY, Kim SW, Heo JH, Kang H, Kim G, An HJ
Oncotarget 2017 Sep 22;8(42):72788-72800

Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway.

Zang MD, Hu L, Fan ZY, Wang HX, Zhu ZL, Cao S, Wu XY, Li JF, Su LP, Li C, Zhu ZG, Yan M, Liu BY
Journal of translational medicine 2017 Feb 27;15(1):52

MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3.

Jeong JY, Kang H, Kim TH, Kim G, Heo JH, Kwon AY, Kim S, Jung SG, An HJ
Cancer letters 2017 Feb 1;386:168-178

Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4.

Shao X, Ding Z, Zhao M, Liu K, Sun H, Chen J, Liu X, Zhang Y, Hong Y, Li H, Li H
The Journal of biological chemistry 2017 Dec 15;292(50):20628-20643

The NOTCH Ligand JAG1 Regulates GDNF Expression in Sertoli Cells.

Garcia TX, Parekh P, Gandhi P, Sinha K, Hofmann MC
Stem cells and development 2017 Apr 15;26(8):585-598

microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia.

Su R, Dong L, Zou D, Zhao H, Ren Y, Li F, Yi P, Li L, Zhu Y, Ma Y, Wang J, Wang F, Yu J
Oncogene 2016 Nov 17;35(46):6001-6014

Notch3-specific inhibition using siRNA knockdown or GSI sensitizes paclitaxel-resistant ovarian cancer cells.

Kang H, Jeong JY, Song JY, Kim TH, Kim G, Huh JH, Kwon AY, Jung SG, An HJ
Molecular carcinogenesis 2016 Jul;55(7):1196-209

EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway.

Xie H, Sun J, Chen Y, Zong M, Li S, Wang Y
Oxidative medicine and cellular longevity 2015;2015:214836

Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia.

Jiang H, Cheng XW, Shi GP, Hu L, Inoue A, Yamamura Y, Wu H, Takeshita K, Li X, Huang Z, Song H, Asai M, Hao CN, Unno K, Koike T, Oshida Y, Okumura K, Murohara T, Kuzuya M
Nature communications 2014 Jun 4;5:3838

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: DU 145 cells were subjected to SDS PAGE followed by western blot with 19929-1-AP(HEY1 antibody) at dilution of 1:3000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human brain using 19929-1-AP(HEY1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The HEY1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human HEY1. This antibody recognizes human,mouse,rat antigen. The HEY1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 19929-1-AP.pdf

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