FNab03849

antibody from FineTest Biotech

Targeting: HEY1 bHLHb31, CHF-2, CHF2, HERP2, HESR-1, HESR1, HRT-1

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ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

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Validation data

Product number: FNab03849 - Provider product page
Provider: FineTest Biotech
Product name: HEY1 antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: hairy/enhancer-of-split related wit h YRPW motif 1
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

HEY1 protein structure - FNab03849 shown in red.