21705-1-AP

antibody from Proteintech Group

Targeting: UQCRC1 D3S3191, QCR1, UQCR1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

21705-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#21705-1-AP, RRID:AB_10734437

Product name

UQCRC1 antibody

Antibody type

Polyclonal

Description

KD/KO validated UQCRC1 antibody (Cat. #21705-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Characterization of a UQCRC1 variant in a patient with progressive weakness, pain and sleep issues reveals a functional mitochondrial defect restored by mitochondrial transplantation.

Piroli GG, Myers R, Holloway L, Hayek A, Linebaugh E, Jones JR, Skinner C, Skinner SA, Frizzell N, Steet R
Molecular genetics and metabolism reports 2026 Mar;46:101302

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Rhein-Emodin Combination Activates UQCRC1 to Attenuate MPP(+)-Induced Ferroptosis in Dopaminergic Neurons.

Yusun A, Wan H, Li S, Liu Y, Chen H, Sun M, Ding X, Zhang C
Chemistry & biodiversity 2026 Mar;23(3):e02053

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Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma.

Zhang H, Wang Z, Zhao Y, Deng X, Zhang J, Shang F, Zhang H, Liu Y, Wang H, Yang Y, Lin H, Zhang B, Liu C, Guo F, Zhang R, Yuan Q, Feng Y, Luo SZ, Chen WD, Wang YD
Nature communications 2026 Mar 6;17(1)

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Mitochondria transplantation mitigates attenuation of muscle fiber regeneration by evoked contractions.

Alway SE, Paez HG, Ferrandi PJ, Pitzer CR, Halle JL, Khan MM, Mohamed JS, Deschenes MR, Carson JA
American journal of physiology. Cell physiology 2026 Jan 1;330(1):C83-C101

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Lactiplantibacillus plantarum GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation.

Lu S, Yue K, He S, Mi J, Yang T, Yang Y, Ma H, Ren Z, Ren L, Xu J
Cellular and molecular life sciences : CMLS 2026 Feb 10;83(1):107

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GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury.

Kuang X, Niu Z, Liu W, Huang Z, Li S, Zhang Y, Wang L, Cai X, Wang F, Zhang P
Frontiers in immunology 2025;16:1712741

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FGL2-induced metabolic dysregulation in enteric neural crest cells provides insight into Hirschsprung disease pathogenesis.

Han J, Liu X, Wang Y, Xu Q, Sun D, Zhang X, He X, Ma C, Ren X, Wang J, Mou Y, Zhang Q, Wang D, Mu W, Hou P, Li A
iScience 2025 Sep 19;28(9):113423

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UQCRC1 is a Key Pathogenic Determinant and Potential Therapeutic Target for Cognitive Impairment in Alzheimer's Disease.

Zhang J, Wu Z, Long Z, Feng C, Bai F, Li H
Molecular neurobiology 2025 Oct;62(10):13786-13806

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Integrated multi-omics analyses of synaptosomes revealed synapse-associated novel targets in Alzheimer's disease.

Kumar S, Ramos E, Hidalgo A, Rodarte D, Sharma B, Torres MM, Devara D, Gadad SS
Molecular psychiatry 2025 Nov;30(11):5121-5136

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CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology.

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Science advances 2025 Nov 14;11(46):eadu0726

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Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration.

Chen X, Zhou Y, Yao W, Gao C, Sha Z, Yi J, Wang J, Liu X, Dai C, Zhang Y, Wu Z, Yao X, Zhou J, Liu H, Chen Y, Ouyang H
Bone research 2025 Mar 17;13(1):37

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Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis-Induced Lung Injury via Macrophage Metabolic Reprogramming.

Zhao Z, Ji J, Ming L, Luo Z, Li M, Chen Y, Sun R, Lu W, Tian W, Yang F, Huang Q
Journal of pineal research 2025 Jul;77(4):e70066

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Integrated Multi-Omics Analyses of Synaptosomes Revealed Synapse-Centered Novel Targets in Alzheimer's Disease.

Kumar S, Ramos E, Hidalgo A, Rodarte D, Sharma B, Torres MM, Devara D, Gadad SS
bioRxiv : the preprint server for biology 2025 Jan 13;

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Lithium compromises the bioenergetic reserve of cardiomyoblasts mitochondria.

Grman M, Balazova M, Horvath A, Polcicova K, Ondacova K, Stepanovsky J, Sevcikova Tomaskova Z
Journal of bioenergetics and biomembranes 2025 Feb;57(1):27-38

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Integrative analysis disclosing UQCRC1 as a potential prognostic and immunological biomarker of lung adenocarcinoma.

Ling L, Peng C, Lin S, Chen Y, Deng M, Qiu H, Huang Y
Pathology, research and practice 2025 Feb;266:155816

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Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling.

Wu H, Guo Z, Hu P, Du J, Wang P, Ma J, Zhao B, Wei J, Li Z
Food & function 2025 Dec 8;16(24):9593-9608

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CAV2-expressing nerves induce metabolic switch toward mitochondrial oxidative phosphorylation to promote cancer stemness.

Zhang Z, Wang C, Sun Z, Shi X, Shuai Y, Wang Y, Wang Y, Guo H, Liu R, Luo J
Nature communications 2025 Dec 2;17(1):203

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Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.

Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952

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FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury.

Yan Y, Ran X, Zhou Z, Gu Y, Wang R, Qiu C, Sun Y, Wang J, Xiao J, Lu Y, Wang J
Frontiers in pharmacology 2024;15:1358646

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COMMD5 counteracts cisplatin-induced nephrotoxicity by maintaining tubular epithelial integrity and autophagy flux.

Ogasawara-Nosoko M, Matsuda H, Ikeda J, Abe M, Masuhiro Y, Endo M, Hamet P, Tremblay J
American journal of physiology. Renal physiology 2024 Nov 1;327(5):F739-F757

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In vitro anticancer effect of azithromycin targeting hypoxic lung cancer cells via the inhibition of mitophagy.

Toriyama K, Okuma T, Abe S, Nakamura H, Aoshiba K
Oncology letters 2024 Jan;27(1):12

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Integrated analysis of metabolomic and transcriptomic profiling reveals the effect of Atractylodes oil on Spleen Yang Deficiency Syndrome in rats.

Zhan X, Xiao Y, Jian Q, Dong Y, Ke C, Zhou Z, Liu Y, Tu J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117205

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Vitamin A regulates mitochondrial biogenesis and function through p38 MAPK-PGC-1α signaling pathway and alters the muscle fiber composition of sheep.

Song P, Zhao J, Li F, Zhao X, Feng J, Su Y, Wang B, Zhao J
Journal of animal science and biotechnology 2024 Feb 4;15(1):18

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Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.

Guo H, Wu H, Hou Y, Hu P, Du J, Cao L, Yang R, Dong X, Li Z
International journal of biological macromolecules 2023 Sep 30;249:126039

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Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.

Gao Y, Long Q, Yang H, Hu Y, Xu Y, Tang C, Gu C, Yong S
Experimental and therapeutic medicine 2023 Nov;26(5):533

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ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.

Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C
Nature communications 2023 Nov 18;14(1):7527

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Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.

Ma B, Ju A, Zhang S, An Q, Xu S, Liu J, Yu L, Fu Y, Luo Y
Signal transduction and targeted therapy 2023 Jun 16;8(1):229

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Targeted clearance of mitochondria by an autophagy-tethering compound (ATTEC) and its potential therapeutic effects.

Tan S, Wang D, Fu Y, Zheng H, Liu Y, Lu B
Science bulletin 2023 Dec 15;68(23):3013-3026

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NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.

Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen G, Li Y, Liao X, Shang Y, Hu G, Chen Q, Zhu Y
The EMBO journal 2023 Aug 15;42(16):e113258

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Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect.

Chen W, Lin W, Yu N, Zhang L, Wu Z, Chen Y, Li Z, Gong F, Li N, Chen X, He X, Wu Y, Zeng X, Yueh Y, Xu R, Ji G
International journal of nanomedicine 2022;17:5431-5446

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Quantitative proteomics identified circulating biomarkers in lung adenocarcinoma diagnosis.

Chen H, Lai X, Zhu Y, Huang H, Zeng L, Zhang L
Clinical proteomics 2022 Nov 21;19(1):44

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Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas.

Wei S, Yin D, Yu S, Lin X, Savani MR, Du K, Ku Y, Wu D, Li S, Liu H, Tian M, Chen Y, Bowie M, Hariharan S, Waitkus M, Keir ST, Sugarman ET, Deek RA, Labrie M, Khasraw M, Lu Y, Mills GB, Herlyn M, Wu K, Liu L, Wei Z, Flaherty KT, Abdullah K, Zhang G, Ashley DM
Clinical cancer research : an official journal of the American Association for Cancer Research 2022 May 13;28(10):2180-2195

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ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.

Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15

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Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.

Zhang P, He Q, Wang Y, Zhou G, Chen Y, Tang L, Zhang Y, Hong X, Mao Y, He Q, Yang X, Liu N, Ma J
Signal transduction and targeted therapy 2022 Feb 16;7(1):46

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Role of molybdenum in material immunomodulation and periodontal wound healing: Targeting immunometabolism and mitochondrial function for macrophage modulation.

He XT, Li X, Zhang M, Tian BM, Sun LJ, Bi CS, Deng DK, Zhou H, Qu HL, Wu C, Chen FM
Biomaterials 2022 Apr;283:121439

---

Melatonin Regulates Differentiation of Sheep Brown Adipocyte Precursor Cells Via AMP-Activated Protein Kinase.

Gao XY, Deng BH, Li XR, Wang Y, Zhang JX, Hao XY, Zhao JX
Frontiers in veterinary science 2021;8:661773

---

MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.

Ding YQ, Zhang YH, Lu J, Li B, Yu WJ, Yue ZB, Hu YH, Wang PX, Li JY, Cai SD, Ye JT, Liu PQ
Acta pharmacologica Sinica 2021 Sep;42(9):1422-1436

---

Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.

Yin D, Jin G, He H, Zhou W, Fan Z, Gong C, Zhao J, Xiong H
Aging 2021 Sep 8;13(17):21268-21282

---

Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.

Hirano T, Suzuki N, Ikenaka Y, Hoshi N, Tabuchi Y
Toxicology and applied pharmacology 2021 Nov 1;430:115723

---

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.

Jin X, Zhang J, Yi Q, Meng F, Yu J, Ji Y, Mo JQ, Tong Y, Jiang P, Guan MX
Investigative ophthalmology & visual science 2021 Jun 1;62(7):22

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An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.

Jin X, Zhang Z, Nie Z, Wang C, Meng F, Yi Q, Chen M, Sun J, Zou J, Jiang P, Guan MX
The Journal of biological chemistry 2021 Jan-Jun;296:100437

---

PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.

Zeng J, Tao J, Xi L, Wang Z, Liu L
International journal of molecular medicine 2021 Apr;47(4)

---

Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.

Deng X, Liu J, Liu L, Sun X, Huang J, Dong J
International journal of biological sciences 2020;16(8):1403-1416

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Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.

Wang Q, Li M, Gan Y, Jiang S, Qiao J, Zhang W, Fan Y, Shen Y, Song Y, Meng Z, Yao M, Gu J, Zhang Z, Tu H
Theranostics 2020;10(5):2141-2157

---

PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.

Ma WQ, Sun XJ, Zhu Y, Liu NF
Cell death & disease 2020 Nov 17;11(11):991

---

Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.

Chen JJ, Tao J, Zhang XL, Xia LZ, Zeng JF, Zhang H, Wei DH, Lv YC, Li GH, Wang Z
DNA and cell biology 2020 Apr;39(4):661-670

---

Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade.

Deng XH, Liu JJ, Sun XJ, Dong JC, Huang JH
Acta pharmacologica Sinica 2019 May;40(5):658-665

---

The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.

Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, Ma K, Chang R, Liu Q, Gao R, Nie J, Xie J, Han J, Chen L, Ma G, Zhu Y, Chen Q
Nature communications 2019 Mar 4;10(1):1034

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Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions.

Fujimaki M, Furuya N, Saiki S, Amo T, Imamichi Y, Hattori N
Molecular and cellular biology 2019 Jul 15;39(14)

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Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.

Deng X, Zhang S, Wu J, Sun X, Shen Z, Dong J, Huang J
Journal of food science 2019 Aug;84(8):2101-2111

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Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.

Fu R, Yang P, Li Z, Liu W, Amin S, Li Z
Cell death & disease 2019 Aug 7;10(8):593

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Induction of PINK1/Parkin-Mediated Mitophagy.

Sato S, Furuya N
Methods in molecular biology (Clifton, N.J.) 2018;1759:9-17

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Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.

Li H, Zhao H, Hao S, Shang L, Wu J, Song C, Meyron-Holtz EG, Qiao T, Li K
Scientific reports 2018 Mar 23;8(1):5118

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CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

Han Y, Sun S, Zhao M, Zhang Z, Gong S, Gao P, Liu J, Zhou J, Ma D, Gao Q, Wu P
Disease markers 2016;2016:3528064

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Tetramethylpyrazine ameliorates high glucose-induced endothelial dysfunction by increasing mitochondrial biogenesis.

Xu Q, Xia P, Li X, Wang W, Liu Z, Gao X
PloS one 2014;9(2):e88243

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Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade.

Li HH, Su JH, Chiu CC, Lin JJ, Yang ZY, Hwang WI, Chen YK, Lo YH, Wu YJ
Marine drugs 2013 Jul 22;11(7):2625-42

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Proteomic analysis of anti-tumor effects of 11-dehydrosinulariolide on CAL-27 cells.

Liu CI, Chen CC, Chen JC, Su JH, Huang HH, Chen JY, Wu YJ
Marine drugs 2011;9(7):1254-1272

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human brain tissue were subjected to SDS PAGE followed by western blot with 21705-1-AP(UQCRC1 antibody) at dilution of 1:500

Sample type

tissue

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using UQCRC1 antibody 21705-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunoprecipitation

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

IP Result of anti-UQCRC1 (IP:21705-1-AP, 4ug; Detection:21705-1-AP 1:500) with HeLa cells lysate 1600ug.

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human heart using 21705-1-AP(UQCRC1 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human heart using 21705-1-AP(UQCRC1 antibody) at dilution of 1:100 (under 40x lens)

Sample type

tissue