Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 21705-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21705-1-AP, RRID:AB_10734437
- Product name
- UQCRC1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UQCRC1 antibody (Cat. #21705-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.
Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.
Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade.
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions.
Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
Induction of PINK1/Parkin-Mediated Mitophagy.
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
Tetramethylpyrazine ameliorates high glucose-induced endothelial dysfunction by increasing mitochondrial biogenesis.
Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade.
Proteomic analysis of anti-tumor effects of 11-dehydrosinulariolide on CAL-27 cells.
Ding YQ, Zhang YH, Lu J, Li B, Yu WJ, Yue ZB, Hu YH, Wang PX, Li JY, Cai SD, Ye JT, Liu PQ
Acta pharmacologica Sinica 2021 Sep;42(9):1422-1436
Acta pharmacologica Sinica 2021 Sep;42(9):1422-1436
Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.
Yin D, Jin G, He H, Zhou W, Fan Z, Gong C, Zhao J, Xiong H
Aging 2021 Sep 8;13(17):21268-21282
Aging 2021 Sep 8;13(17):21268-21282
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.
Hirano T, Suzuki N, Ikenaka Y, Hoshi N, Tabuchi Y
Toxicology and applied pharmacology 2021 Nov 1;430:115723
Toxicology and applied pharmacology 2021 Nov 1;430:115723
Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.
Jin X, Zhang J, Yi Q, Meng F, Yu J, Ji Y, Mo JQ, Tong Y, Jiang P, Guan MX
Investigative ophthalmology & visual science 2021 Jun 1;62(7):22
Investigative ophthalmology & visual science 2021 Jun 1;62(7):22
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Jin X, Zhang Z, Nie Z, Wang C, Meng F, Yi Q, Chen M, Sun J, Zou J, Jiang P, Guan MX
The Journal of biological chemistry 2021 Jan-Jun;296:100437
The Journal of biological chemistry 2021 Jan-Jun;296:100437
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Zeng J, Tao J, Xi L, Wang Z, Liu L
International journal of molecular medicine 2021 Apr;47(4)
International journal of molecular medicine 2021 Apr;47(4)
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J
International journal of biological sciences 2020;16(8):1403-1416
International journal of biological sciences 2020;16(8):1403-1416
Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.
Wang Q, Li M, Gan Y, Jiang S, Qiao J, Zhang W, Fan Y, Shen Y, Song Y, Meng Z, Yao M, Gu J, Zhang Z, Tu H
Theranostics 2020;10(5):2141-2157
Theranostics 2020;10(5):2141-2157
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Cell death & disease 2020 Nov 17;11(11):991
Cell death & disease 2020 Nov 17;11(11):991
Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.
Chen JJ, Tao J, Zhang XL, Xia LZ, Zeng JF, Zhang H, Wei DH, Lv YC, Li GH, Wang Z
DNA and cell biology 2020 Apr;39(4):661-670
DNA and cell biology 2020 Apr;39(4):661-670
Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade.
Deng XH, Liu JJ, Sun XJ, Dong JC, Huang JH
Acta pharmacologica Sinica 2019 May;40(5):658-665
Acta pharmacologica Sinica 2019 May;40(5):658-665
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, Ma K, Chang R, Liu Q, Gao R, Nie J, Xie J, Han J, Chen L, Ma G, Zhu Y, Chen Q
Nature communications 2019 Mar 4;10(1):1034
Nature communications 2019 Mar 4;10(1):1034
Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions.
Fujimaki M, Furuya N, Saiki S, Amo T, Imamichi Y, Hattori N
Molecular and cellular biology 2019 Jul 15;39(14)
Molecular and cellular biology 2019 Jul 15;39(14)
Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.
Deng X, Zhang S, Wu J, Sun X, Shen Z, Dong J, Huang J
Journal of food science 2019 Aug;84(8):2101-2111
Journal of food science 2019 Aug;84(8):2101-2111
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
Fu R, Yang P, Li Z, Liu W, Amin S, Li Z
Cell death & disease 2019 Aug 7;10(8):593
Cell death & disease 2019 Aug 7;10(8):593
Induction of PINK1/Parkin-Mediated Mitophagy.
Sato S, Furuya N
Methods in molecular biology (Clifton, N.J.) 2018;1759:9-17
Methods in molecular biology (Clifton, N.J.) 2018;1759:9-17
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
Li H, Zhao H, Hao S, Shang L, Wu J, Song C, Meyron-Holtz EG, Qiao T, Li K
Scientific reports 2018 Mar 23;8(1):5118
Scientific reports 2018 Mar 23;8(1):5118
CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
Han Y, Sun S, Zhao M, Zhang Z, Gong S, Gao P, Liu J, Zhou J, Ma D, Gao Q, Wu P
Disease markers 2016;2016:3528064
Disease markers 2016;2016:3528064
Tetramethylpyrazine ameliorates high glucose-induced endothelial dysfunction by increasing mitochondrial biogenesis.
Xu Q, Xia P, Li X, Wang W, Liu Z, Gao X
PloS one 2014;9(2):e88243
PloS one 2014;9(2):e88243
Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade.
Li HH, Su JH, Chiu CC, Lin JJ, Yang ZY, Hwang WI, Chen YK, Lo YH, Wu YJ
Marine drugs 2013 Jul 22;11(7):2625-42
Marine drugs 2013 Jul 22;11(7):2625-42
Proteomic analysis of anti-tumor effects of 11-dehydrosinulariolide on CAL-27 cells.
Liu CI, Chen CC, Chen JC, Su JH, Huang HH, Chen JY, Wu YJ
Marine drugs 2011;9(7):1254-72
Marine drugs 2011;9(7):1254-72
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 21705-1-AP(UQCRC1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using UQCRC1 antibody 21705-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-UQCRC1 (IP:21705-1-AP, 4ug; Detection:21705-1-AP 1:500) with HeLa cells lysate 1600ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 21705-1-AP(UQCRC1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 21705-1-AP(UQCRC1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue