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- References [27]
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- Product number
- 12212-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12212-1-AP, RRID:AB_2195320
- Product name
- SSBP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SSBP1 antibody (Cat. #12212-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
Stress response silencing by an E3 ligase mutated in neurodegeneration.
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
The proteomic landscape of genotoxic stress-induced micronuclei.
Evaluation of mitochondrial biogenesis and ROS generation in high-grade serous ovarian cancer.
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.
Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway.
REC drives recombination to repair double-strand breaks in animal mtDNA.
Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3 to the single-stranded DNA-binding protein 1 (SSBP1) promoter region.
A deafness-associated mitochondrial DNA mutation caused pleiotropic effects on DNA replication and tRNA metabolism.
A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication.
Top3α is the replicative topoisomerase in mitochondrial DNA replication.
The FASTK family proteins fine-tune mitochondrial RNA processing.
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication.
The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex.
LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival.
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes.
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.
Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family.
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
PrimPol is required for replication reinitiation after mtDNA damage.
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion.
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication.
Tábara LC, Burr SP, Frison M, Chowdhury SR, Paupe V, Nie Y, Johnson M, Villar-Azpillaga J, Viegas F, Segawa M, Anand H, Petkevicius K, Chinnery PF, Prudent J
Cell 2024 Jul 11;187(14):3619-3637.e27
Cell 2024 Jul 11;187(14):3619-3637.e27
Stress response silencing by an E3 ligase mutated in neurodegeneration.
Haakonsen DL, Heider M, Ingersoll AJ, Vodehnal K, Witus SR, Uenaka T, Wernig M, Rapé M
Nature 2024 Feb;626(8000):874-880
Nature 2024 Feb;626(8000):874-880
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S, Rodriguez-Enriquez R, Chevez JA, Lemersal I, Manor U, Shadel GS
Nature cell biology 2024 Feb;26(2):194-206
Nature cell biology 2024 Feb;26(2):194-206
The proteomic landscape of genotoxic stress-induced micronuclei.
MacDonald KM, Khan S, Lin B, Hurren R, Schimmer AD, Kislinger T, Harding SM
Molecular cell 2024 Apr 4;84(7):1377-1391.e6
Molecular cell 2024 Apr 4;84(7):1377-1391.e6
Evaluation of mitochondrial biogenesis and ROS generation in high-grade serous ovarian cancer.
Koc ZC, Sollars VE, Bou Zgheib N, Rankin GO, Koc EC
Frontiers in oncology 2023;13:1129352
Frontiers in oncology 2023;13:1129352
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.
Zhang J, Simpson CM, Berner J, Chong HB, Fang J, Ordulu Z, Weiss-Sadan T, Possemato AP, Harry S, Takahashi M, Yang TY, Richter M, Patel H, Smith AE, Carlin AD, Hubertus de Groot AF, Wolf K, Shi L, Wei TY, Dürr BR, Chen NJ, Vornbäumen T, Wichmann NO, Mahamdeh MS, Pooladanda V, Matoba Y, Kumar S, Kim E, Bouberhan S, Oliva E, Rueda BR, Soberman RJ, Bardeesy N, Liau BB, Lawrence M, Stokes MP, Beausoleil SA, Bar-Peled L
Cell 2023 May 25;186(11):2361-2379.e25
Cell 2023 May 25;186(11):2361-2379.e25
Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway.
Zhang J, Simpson CM, Berner J, Chong HB, Fang J, Sahin ZO, Weiss-Sadan T, Possemato AP, Harry S, Takahashi M, Yang TY, Richter M, Patel H, Smith AE, Carlin AD, Hubertus de Groot AF, Wolf K, Shi L, Wei TY, Dürr BR, Chen NJ, Vornbäumen T, Wichmann NO, Pooladanda V, Matoba Y, Kumar S, Kim E, Bouberhan S, Olivia E, Rueda B, Bardeesy N, Liau B, Lawrence M, Stokes MP, Beausoleil SA, Bar-Peled L
bioRxiv : the preprint server for biology 2023 Mar 11;
bioRxiv : the preprint server for biology 2023 Mar 11;
REC drives recombination to repair double-strand breaks in animal mtDNA.
Klucnika A, Mu P, Jezek J, McCormack M, Di Y, Bradshaw CR, Ma H
The Journal of cell biology 2023 Jan 2;222(1)
The Journal of cell biology 2023 Jan 2;222(1)
Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3 to the single-stranded DNA-binding protein 1 (SSBP1) promoter region.
Wang KD, Zhu ML, Qin CJ, Dong RF, Xiao CM, Lin Q, Wei RY, He XY, Zang X, Kong LY, Xia YZ
British journal of pharmacology 2023 Dec;180(24):3175-3193
British journal of pharmacology 2023 Dec;180(24):3175-3193
A deafness-associated mitochondrial DNA mutation caused pleiotropic effects on DNA replication and tRNA metabolism.
Meng F, Jia Z, Zheng J, Ji Y, Wang J, Xiao Y, Fu Y, Wang M, Ling F, Guan MX
Nucleic acids research 2022 Sep 9;50(16):9453-9469
Nucleic acids research 2022 Sep 9;50(16):9453-9469
A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication.
Kozhukhar N, Spadafora D, Rodriguez YAR, Alexeyev MF
Cells 2022 Jul 11;11(14)
Cells 2022 Jul 11;11(14)
Top3α is the replicative topoisomerase in mitochondrial DNA replication.
Hangas A, Kekäläinen NJ, Potter A, Michell C, Aho KJ, Rutanen C, Spelbrink JN, Pohjoismäki JL, Goffart S
Nucleic acids research 2022 Aug 26;50(15):8733-8748
Nucleic acids research 2022 Aug 26;50(15):8733-8748
The FASTK family proteins fine-tune mitochondrial RNA processing.
Ohkubo A, Van Haute L, Rudler DL, Stentenbach M, Steiner FA, Rackham O, Minczuk M, Filipovska A, Martinou JC
PLoS genetics 2021 Nov;17(11):e1009873
PLoS genetics 2021 Nov;17(11):e1009873
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication.
Jiang M, Xie X, Zhu X, Jiang S, Milenkovic D, Misic J, Shi Y, Tandukar N, Li X, Atanassov I, Jenninger L, Hoberg E, Albarran-Gutierrez S, Szilagyi Z, Macao B, Siira SJ, Carelli V, Griffith JD, Gustafsson CM, Nicholls TJ, Filipovska A, Larsson NG, Falkenberg M
Science advances 2021 Jul;7(27)
Science advances 2021 Jul;7(27)
The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex.
Zhou M, Yang Z, Wang D, Chen P, Zhang Y
Journal of experimental & clinical cancer research : CR 2021 Jan 30;40(1):48
Journal of experimental & clinical cancer research : CR 2021 Jan 30;40(1):48
LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival.
Lee YG, Kim HW, Nam Y, Shin KJ, Lee YJ, Park DH, Rhee HW, Seo JK, Chae YC
Oncogenesis 2021 Feb 26;10(2):18
Oncogenesis 2021 Feb 26;10(2):18
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Rey T, Zaganelli S, Cuillery E, Vartholomaiou E, Croisier M, Martinou JC, Manley S
Nature cell biology 2020 Oct;22(10):1180-1186
Nature cell biology 2020 Oct;22(10):1180-1186
Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes.
Gustafson MA, McCormick EM, Perera L, Longley MJ, Bai R, Kong J, Dulik M, Shen L, Goldstein AC, McCormack SE, Laskin BL, Leroy BP, Ortiz-Gonzalez XR, Ellington MG, Copeland WC, Falk MJ
PloS one 2019;14(9):e0221829
PloS one 2019;14(9):e0221829
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.
Horita H, Law A, Middleton K
Proteomes 2018 May 22;6(2)
Proteomes 2018 May 22;6(2)
Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family.
Kullar PJ, Gomez-Duran A, Gammage PA, Garone C, Minczuk M, Golder Z, Wilson J, Montoya J, Häkli S, Kärppä M, Horvath R, Majamaa K, Chinnery PF
Brain : a journal of neurology 2018 Jan 1;141(1):55-62
Brain : a journal of neurology 2018 Jan 1;141(1):55-62
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F
Journal of Cancer 2017;8(8):1400-1409
Journal of Cancer 2017;8(8):1400-1409
PrimPol is required for replication reinitiation after mtDNA damage.
Torregrosa-Muñumer R, Forslund JME, Goffart S, Pfeiffer A, Stojkovič G, Carvalho G, Al-Furoukh N, Blanco L, Wanrooij S, Pohjoismäki JLO
Proceedings of the National Academy of Sciences of the United States of America 2017 Oct 24;114(43):11398-11403
Proceedings of the National Academy of Sciences of the United States of America 2017 Oct 24;114(43):11398-11403
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion.
Phillips AF, Millet AR, Tigano M, Dubois SM, Crimmins H, Babin L, Charpentier M, Piganeau M, Brunet E, Sfeir A
Molecular cell 2017 Feb 2;65(3):527-538.e6
Molecular cell 2017 Feb 2;65(3):527-538.e6
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
Zhao X, Sun K, Lan Z, Song W, Cheng L, Chi W, Chen J, Huo Y, Xu L, Liu X, Deng H, Siegenthaler JA, Chen L
Scientific reports 2017 Apr 11;7:46344
Scientific reports 2017 Apr 11;7:46344
MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.
Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A
Cell 2016 Oct 20;167(3):722-738.e23
Cell 2016 Oct 20;167(3):722-738.e23
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92
Cell death and differentiation 2016 Mar;23(3):380-92
In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication.
Miralles Fusté J, Shi Y, Wanrooij S, Zhu X, Jemt E, Persson Ö, Sabouri N, Gustafsson CM, Falkenberg M
PLoS genetics 2014 Dec;10(12):e1004832
PLoS genetics 2014 Dec;10(12):e1004832
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SSBP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SSBP1. This antibody recognizes human, mouse, rat antigen. The SSBP1 antibody has been validated for the following applications: ELISA, WB analysis.
