18233-1-AP

antibody from Proteintech Group

Targeting: PDIA6 ERp5, P5, TXNDC7

Provider product page for 18233-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [29]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

Submit

Product number: 18233-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18233-1-AP, RRID:AB_10805765
Product name: PDIA6 antibody
Antibody type: Polyclonal
Description: PDIA6 antibody (Cat. #18233-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PDIA6 protein structure - 18233-1-AP shown in red.

Submitted references SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis.

Liu S, Gad M, Li C, Cho K, Liu Y, Wangdu K, Belay V, Millet A, Kojima H, Sanford H, Wölk M, Urnavicius L, Fedorova M, Patti GJ, Vinogradova EV, Hite RK, Birsoy K
Nature cell biology 2026 May;28(5):903-914

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis.

Liu S, Gad M, Li C, Cho K, Liu Y, Wangdu K, Belay V, Millet A, Kojima H, Sanford H, Wölk M, Urnavicius L, Fedorova M, Patti GJ, Vinogradova EV, Hite RK, Birsoy K
bioRxiv : the preprint server for biology 2026 Mar 16;

PDIA6 as a novel pharmacological target for metabolic dysfunction-associated steatohepatitis via alleviating endoplasmic reticulum stress.

Hu H, Liao J, Yang S, Li W, Feng S, Zhang Y, Lin Q, Huang J, He W, Liu D, Gao L, Zhang Q, Luo P, Wang J
Free radical biology & medicine 2026 Jul;250:258-273

Ca(2+)-driven PDIA6 biomolecular condensation ensures proinsulin folding.

Lee YH, Saio T, Watabe M, Matsusaki M, Kanemura S, Lin Y, Mannen T, Kuramochi T, Kamada Y, Iuchi K, Tajiri M, Suzuki K, Li Y, Heo Y, Ishii K, Arai K, Ban K, Hashimoto M, Oshita S, Ninagawa S, Hattori Y, Kumeta H, Takeuchi A, Kajimoto S, Abe H, Mori E, Muraoka T, Nakabayashi T, Akashi S, Okiyoneda T, Vendruscolo M, Inaba K, Okumura M
Nature cell biology 2025 Nov;27(11):1952-1964

Gene Therapy with Enterovirus 3 C Protease: A Promising Strategy for Various Solid Tumors.

Yang X, Li W, Yang S, Wang Z, Yin J, Zhang W, Tao H, Li S, Guo X, Dai Q, Zhu W, Li Y, Yan X, Luo C, Li J, Ren S, Wang P, Shao Y, Luo Y, Li Z, Yang J, Chang Z, Cao R, Li S, Zhong W
Nature communications 2025 May 8;16(1):4298

Endoplasmic reticulum protein 29 negatively regulates platelet functions and thrombosis in mice.

Yan X, Lu Y, Lv K, Jiang M, Fang C, Wu Y, Yang A
Thrombosis journal 2025 May 7;23(1):44

Integrated Nanopore and short-read RNA sequencing identifies dysregulation of METTL3- m6A modifications in endocrine therapy- sensitive and resistant breast cancer cells.

Petri BJ, Piell KM, Avila-Valdes BL, Stanley CG, Winkler LJ, Brown JT, Ulett R, Sanchez G, Chariker JH, Rouchka EC, Klinge CM
Functional & integrative genomics 2025 Jul 9;25(1):149

Hu D, Wen W, Li H, Zhang Z, Lin H, Luo J
bioRxiv : the preprint server for biology 2025 Aug 1;

Sex-specific effects of alcohol on neurobehavioral performance and endoplasmic reticulum stress: an analysis using neuron-specific MANF deficient mice.

Wen W, Li H, Lauffer M, Hu D, Zhang Z, Lin H, Wang Y, Leidinger M, Luo J
Frontiers in pharmacology 2024;15:1407576

Ginsenoside Rh2 enhances immune surveillance of natural killer (NK) cells via inhibition of ERp5 in breast cancer.

Yang C, Qian C, Zheng W, Dong G, Zhang S, Wang F, Wei Z, Xu Y, Wang A, Zhao Y, Lu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155180

Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion.

Chen Z, Wang S, Pottekat A, Duffey A, Jang I, Chang BH, Cho J, Finck BN, Davidson NO, Kaufman RJ
Molecular metabolism 2024 Feb;80:101874

ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones.

Tao S, Yang EJ, Zong G, Mou PK, Ren G, Pu Y, Chen L, Kwon HJ, Zhou J, Hu Z, Khosravi A, Zhang Q, Du Y, Shi WQ, Shim JS
International journal of biological sciences 2023;19(13):4020-4035

MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells.

Morimoto Y, Yamashita N, Daimon T, Hirose H, Yamano S, Haratake N, Ishikawa S, Bhattacharya A, Fushimi A, Ahmad R, Takahashi H, Dashevsky O, Mitsiades C, Kufe D
Journal for immunotherapy of cancer 2023 Feb;11(2)

Assembly-dependent Structure Formation Shapes Human Interleukin-23 versus Interleukin-12 Secretion.

Aschenbrenner I, Siebenmorgen T, Lopez A, Parr M, Ruckgaber P, Kerle A, Rührnößl F, Catici D, Haslbeck M, Frishman D, Sattler M, Zacharias M, Feige MJ
Journal of molecular biology 2023 Dec 1;435(23):168300

Venezuelan equine encephalitis virus E1 protein interacts with PDIA6 and PDI inhibition reduces alphavirus production.

Panny L, Akrhymuk I, Bracci N, Woodson C, Flor R, Elliott I, Zhou W, Narayanan A, Campbell C, Kehn-Hall K
Antiviral research 2023 Apr;212:105560

COG4 mutation in Saul-Wilson syndrome selectively affects secretion of proteins involved in chondrogenesis in chondrocyte-like cells.

Xia ZJ, Mahajan S, Paul Daniel EJ, Ng BG, Saraswat M, Campos AR, Murad R, He M, Freeze HH
Frontiers in cell and developmental biology 2022;10:979096

Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.

Zhang S, Huang W, Ren L, Ju X, Gong M, Rao J, Sun L, Li P, Ding Q, Wang J, Zhang QC
Cell research 2022 Jan;32(1):9-23

A comprehensive set of ER protein disulfide isomerase family members supports the biogenesis of proinflammatory interleukin 12 family cytokines.

Mideksa YG, Aschenbrenner I, Fux A, Kaylani D, Weiß CAM, Nguyen TA, Bach NC, Lang K, Sieber SA, Feige MJ
The Journal of biological chemistry 2022 Dec;298(12):102677

Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis.

Mestre-Farràs N, Guerrero S, Bley N, Rivero E, Coll O, Borràs E, Sabidó E, Indacochea A, Casillas-Serra C, Järvelin AI, Oliva B, Castello A, Hüttelmaier S, Gebauer F
Nucleic acids research 2022 Aug 12;50(14):8207-8225

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.

Chhabra NF, Amend AL, Bastidas-Ponce A, Sabrautzki S, Tarquis-Medina M, Sachs S, Rubey M, Lorenz-Depiereux B, Feuchtinger A, Bakhti M, Lickert H, Przemeck GKH, Hrabě de Angelis M
Molecular metabolism 2021 Dec;54:101334

Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis".

Han C, Jiang YH, Li W, Liu Y
Journal of ethnopharmacology 2021 Apr 6;269:113768

Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development.

Choi JH, Zhong X, Zhang Z, Su L, McAlpine W, Misawa T, Liao TC, Zhan X, Russell J, Ludwig S, Li X, Tang M, Anderton P, Moresco EMY, Beutler B
The Journal of experimental medicine 2020 Apr 6;217(4)

PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.

Jang I, Pottekat A, Poothong J, Yong J, Lagunas-Acosta J, Charbono A, Chen Z, Scheuner DL, Liu M, Itkin-Ansari P, Arvan P, Kaufman RJ
eLife 2019 Jun 11;8

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G
Cancer cell 2019 Feb 11;35(2):204-220.e9

PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway.

Bai Y, Liu X, Qi X, Liu X, Peng F, Li H, Fu H, Pei S, Chen L, Chi X, Zhang L, Zhu X, Song Y, Wang Y, Meng S, Jiang T, Shao S
EBioMedicine 2019 Apr;42:311-325

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N
Oncotarget 2017 Nov 28;8(61):103543-103556

Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.

Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, Wang F, Chi X, Jiang Y, Shao S
PloS one 2016;11(9):e0163622

PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway.

Gao H, Sun B, Fu H, Chi X, Wang F, Qi X, Hu J, Shao S
Oncotarget 2016 Aug 16;7(33):53289-53298

The alteration of protein profile induced by cigarette smoking via oxidative stress in mice epididymis.

Zhu Z, Xu W, Dai J, Chen X, Zhao X, Fang P, Yang F, Tang M, Wang Z, Wang L, Ma D, Qaio Z
The international journal of biochemistry & cell biology 2013 Mar;45(3):571-82

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 18233-1-AP(PDIA6 antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human stomach using 18233-1-AP(PDIA6 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PDIA6 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PDIA6. This antibody recognizes human, mouse, rat antigen. The PDIA6 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 18233-1-AP.pdf

: Show more