ZNF426

Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Description

Zinc finger protein 426

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

19 (9523223 - 9538645)

Ensembl ID

ENSG00000130818  (ver. 103.38)

Orthologs

Mouse Zfp426: ENSMUSG00000059475

UniProt

Q9BUY5

neXtProt

NX_Q9BUY5

Human splice variants
Mouse splice variants

Protein structure