ABIN1673197

antibody from antibodies-online

Targeting: SDHB SDH, SDH1

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN1673197

Provider

antibodies-online

Product name

anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) (N-Term) antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide corresponding to a sequence at the N-terminal of human SDHB, different from the related rat sequence by one amino acid and mouse sequence by two amino acids.Immunogen affinity purified.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

N-Term

Isotype

IgG

Vial size

100 μg

Storage

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing.

Brouwers FM, Eisenhofer G, Tao JJ, Kant JA, Adams KT, Linehan WM, Pacak K
The Journal of clinical endocrinology and metabolism 2006 Nov;91(11):4505-9

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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.

Pollard PJ, Brière JJ, Alam NA, Barwell J, Barclay E, Wortham NC, Hunt T, Mitchell M, Olpin S, Moat SJ, Hargreaves IP, Heales SJ, Chung YL, Griffiths JR, Dalgleish A, McGrath JA, Gleeson MJ, Hodgson SV, Poulsom R, Rustin P, Tomlinson IP
Human molecular genetics 2005 Aug 1;14(15):2231-9

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Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase.

Au HC, Ream-Robinson D, Bellew LA, Broomfield PL, Saghbini M, Scheffler IE
Gene 1995 Jul 4;159(2):249-53