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- Antigen structure
- References [132]
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- Product number
- 10620-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10620-1-AP, RRID:AB_2285522
- Product name
- SDHB antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SDHB antibody (Cat. #10620-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting NDUFS8 in basal forebrain ameliorates cognitive decline related to chronic cerebral hypoperfusion.
Osteoblast-derived osteomodulin restrains osteoclastogenesis via ITGB8/RRM2-mediated reduction of mitochondrial respiration and mitochondrial ATP production.
Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma.
Resveratrol alleviates neuropathic pain associated with restoration of mitochondrial fission-fusion balance in CCI mice.
Polyethylene terephthalate microplastics impair erectile function through macrophage mediated cGAS-STING ferroptosis.
Metabolic beneficial effects of targeting a long non-coding RNA, lnc-megacluster, in obesity.
PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury.
Activation of the integrated stress response contributes to developmental delay and seizures caused by mitochondrial prolyl-tRNA synthetase (PARS2) deficiency.
Lactiplantibacillus plantarum GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation.
Placental mitochondrial respiration is inhibited in mice with trophoblast specific AdipoR2 overexpression.
Spatiotemporal controlled release of YCM/Cu(2)⁺ hydrogel microneedle system synergistically accelerates chronic wound healing in diabetes.
Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model.
Single-Cell RNA Sequencing Reveals Microglial Heterogeneity and Functional States After Cerebral Ischemia-Reperfusion Injury.
Dexmedetomidine alleviates lung ischemia-reperfusion injury by inhibiting cuproptosis: an in vivo study.
Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer.
Knockdown of ACC1 promotes migration and invasion of U251 glioma cells by epigenetically suppressing SDH.
Hexokinase-2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming.
C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer.
FGL2-induced metabolic dysregulation in enteric neural crest cells provides insight into Hirschsprung disease pathogenesis.
A galacturonan from sea buckthorn (Hippophae rhamnoides L.) berry modulates dyslipidemia by promoting hepatic lipolysis and mitochondrial oxidation.
Iron overload exaggerates renal ischemia-reperfusion injury by promoting tubular cuproptosis via interrupting function of LIAS.
Mitochondrial electron transport chain gene-based prognostic model identifies SDHB as a key regulator of low-grade glioma progression and therapeutic target.
SIRT7 drives energy metabolic shifts in endometriosis via interaction with TUFM and Rhoa/Rock/Akt pathway activation.
Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male mice.
Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer.
FXR suppress Müller cell activation by regulating cGAS/STING pathway in diabetic retinopathy.
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death.
Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson's Disease.
Selenoprotein K Confers Protection against Iron Dyshomeostasis-Related Neurotoxicity by Regulating the Palmitoylation of TfR-1.
Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging.
Effects of polystyrene microparticles exposures on spermatogenic cell differentiation and reproductive endpoints in male mice.
Impact of POU3F4 mutation on cochlear development and auditory function.
Isolated Mitochondrial Transplantation as a Novel Treatment for Corneal Chemical Burns.
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration.
The mitochondrial protease ClpP is a promising target for multiple myeloma treatment.
TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3.
Targeted Reprogramming of Macrophages by Nanozyme for Accelerated Wound Healing.
MitCOM-based prognostic model identifies GLUD1 as a key suppressor of glioblastoma growth and invasion through regulation of mitochondrial structure and metabolism.
Corticosterone induces fatty liver syndrome in chickens via glucocorticoid receptor and inhibition of mitochondrial supercomplex formation.
Astroglial membrane camouflaged Ptbp1 siRNA delivery hinders glutamate homeostasis via SDH/Nrf2 pathway.
Impaired Iron-Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy.
hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling.
Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment.
Endothelial FUNDC1 Deficiency Drives Pulmonary Hypertension.
Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse.
Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.
Drosophila modeling to identify causative genes and reveal the underlying molecular mechanisms for primary ovarian insufficiency.
SRF/SLC31A1 signaling promotes cuproptosis induced by celastrol in NSCLC.
MDPAO1 peptide from human milk enhances brown adipose tissue thermogenesis and mitigates obesity.
NAD(+) Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT.
Darunavir analog precursors target mitochondrial metabolism in multiple myeloma and CLL.
CAV2-expressing nerves induce metabolic switch toward mitochondrial oxidative phosphorylation to promote cancer stemness.
Liraglutide alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by enhancing mitophagy mediated by the AMPK-Parkin signaling pathway.
CX3CL1 deficiency ameliorates acute kidney injury by inhibiting macrophage mitochondrial dysfunction and mtDNA-cGAS-STING signaling.
Leber's hereditary optic neuropathy-associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis.
Evidence that mitochondria in macrophages are destroyed by microautophagy.
Succinate links TCA cycle dysfunction to inflammation by activating HIF-1α signaling in acute kidney injury.
NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy.
Intrauterine inflammation-induced neonatal lung injury via succinic acid-mediated alveolar epithelial E-cadherin downregulation.
Retromer promotes the lysosomal turnover of mtDNA.
Idebenone improves mitochondrial respiratory activity and attenuates oxidative damage via the SIRT3-SOD2 pathway in a prion disease cell model.
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.
Identification and validation of cuproptosis-related genes in acetaminophen-induced liver injury using bioinformatics analysis and machine learning.
FDX2, an iron-sulfur cluster assembly factor, is essential to prevent cellular senescence, apoptosis or ferroptosis of ovarian cancer cells.
Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity.
Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts.
Novel Insights Into DLAT's Role in Alzheimer's Disease-Related Copper Toxicity Through Microglial Exosome Dynamics.
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Acrylamide Exposure Impairs Ovarian Tricarboxylic Acid Cycle and Reduces Oocyte Quality in Mouse.
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model.
Taurine hypomodification underlies mitochondrial tRNATrp-related genetic diseases.
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation.
Metformin induction of heat shock factor 1 activation and the mitochondrial unfolded protein response alleviate cardiac remodeling in spontaneously hypertensive rats.
Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication.
BNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC.
Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer's Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice.
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
Intervention of Tanshinone IIA on the PGK1-PDHK1 Pathway to Reprogram Macrophage Phenotype After Myocardial Infarction.
Colorectal cancer cells establish metabolic reprogramming with cancer-associated fibroblasts (CAFs) through lactate shuttle to enhance invasion, migration, and angiogenesis.
TRIM24-DTNBP1-ATP7A mediated astrocyte cuproptosis in cognition and memory dysfunction caused by Y(2)O(3) NPs.
mTORC1 Signaling Inhibition Modulates Mitochondrial Function in Frataxin Deficiency.
Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling.
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides.
Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity.
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy.
Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway.
A mitochondrial iron-responsive pathway regulated by DELE1.
Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells.
A high-fat diet increases hepatic mitochondrial turnover through restricted acetylation in a NAFLD mouse model.
Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation.
Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation.
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration.
Claudin-10 overexpression suppresses human clear cell renal cell carcinoma growth and metastasis by regulating ATP5O and causing mitochondrial dysfunction.
CHCHD10 Modulates Thermogenesis of Adipocytes by Regulating Lipolysis.
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia-reperfusion injure by restoring CPT1A mediated fatty acid oxidation.
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3.
Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells.
Yiqi Huoxue Tongluo recipe regulates NR4A1 to improve renal mitochondrial function in unilateral ureteral obstruction (UUO) rats.
Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death.
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.
Imatinib Regulates miR-483-3p and Mitochondrial Respiratory Complexes in Gastrointestinal Stromal Tumors.
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells.
Selenium-dependent metabolic reprogramming during inflammation and resolution.
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.
A Renal Cell Carcinoma with Biallelic Somatic TSC2 Mutation: Clinical Study and Literature Review.
Germline SDHB and SDHD mutations in pheochromocytoma and paraganglioma patients.
miR-148b-3p functions as a tumor suppressor in GISTs by directly targeting KIT.
SDHB deficiency promotes TGFβ-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4.
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Qu Y, Xu X, Wang X, Yang J, Zhang L, Wang T, Tang X, Cheng W, Li J, Ma J, Wu Y, Xu W, Wang Q, Zeng L, An X, Wang D, Chen M, Cong G, Wu Y, Sun B, Ai J
Theranostics 2026;16(3):1328-1349
Theranostics 2026;16(3):1328-1349
Osteoblast-derived osteomodulin restrains osteoclastogenesis via ITGB8/RRM2-mediated reduction of mitochondrial respiration and mitochondrial ATP production.
Jiang X, Chen H, Hou W, Dai C, Zhang R, Chen E, Zhang J, Wu W, Xu J, Chen M, Liu L, Tan X, Ji X, Wu X, Wang K, Yu C, Yu X, Li W, Zhang W
Experimental & molecular medicine 2026 Mar;58(3):879-897
Experimental & molecular medicine 2026 Mar;58(3):879-897
Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma.
Zhang H, Wang Z, Zhao Y, Deng X, Zhang J, Shang F, Zhang H, Liu Y, Wang H, Yang Y, Lin H, Zhang B, Liu C, Guo F, Zhang R, Yuan Q, Feng Y, Luo SZ, Chen WD, Wang YD
Nature communications 2026 Mar 6;17(1)
Nature communications 2026 Mar 6;17(1)
Resveratrol alleviates neuropathic pain associated with restoration of mitochondrial fission-fusion balance in CCI mice.
Xie L, Xu Y, Yang Q, Chang W, Song L, Sun Y
Scientific reports 2026 Mar 4;16(1)
Scientific reports 2026 Mar 4;16(1)
Polyethylene terephthalate microplastics impair erectile function through macrophage mediated cGAS-STING ferroptosis.
Liu S, Wang W, Zhang Y, Li S, Jia H, Liu S, Wu L, Dou P, Li J, Jiang C, Zhao F
iScience 2026 Mar 20;29(3):115044
iScience 2026 Mar 20;29(3):115044
Metabolic beneficial effects of targeting a long non-coding RNA, lnc-megacluster, in obesity.
Abdollahi M, Malek V, Tanwar VS, Kato M, Lanting L, Rezaei A, Zhang L, Yang L, Pillai RK, Kebrom L, Nandi J, Huang W, Ma K, Natarajan R
Molecular therapy. Nucleic acids 2026 Mar 12;37(1):102792
Molecular therapy. Nucleic acids 2026 Mar 12;37(1):102792
PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury.
Li Y, Wang Y, Zhang H, Xu P, Yuan X, Yuan H, Yang C, Zhou Y, Shen J, Du H, Gao Z, Zang J, Liang S, Qu J, Song M
Basic research in cardiology 2026 Jun;121(3):395-412
Basic research in cardiology 2026 Jun;121(3):395-412
Activation of the integrated stress response contributes to developmental delay and seizures caused by mitochondrial prolyl-tRNA synthetase (PARS2) deficiency.
Xu M, Liu Y, Ma R, Fan W, Duan J, Deng H, Ma Y, Ge W
Redox biology 2026 Feb;89:103966
Redox biology 2026 Feb;89:103966
Lactiplantibacillus plantarum GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation.
Lu S, Yue K, He S, Mi J, Yang T, Yang Y, Ma H, Ren Z, Ren L, Xu J
Cellular and molecular life sciences : CMLS 2026 Feb 10;83(1):107
Cellular and molecular life sciences : CMLS 2026 Feb 10;83(1):107
Placental mitochondrial respiration is inhibited in mice with trophoblast specific AdipoR2 overexpression.
Shimada H, Sakuragi T, Barentsen K, Erickson K, Urschitz J, Powell TL, Jansson T, Rosario FJ
Free radical biology & medicine 2026 Feb 1;243:276-290
Free radical biology & medicine 2026 Feb 1;243:276-290
Spatiotemporal controlled release of YCM/Cu(2)⁺ hydrogel microneedle system synergistically accelerates chronic wound healing in diabetes.
Zhang M, Pang Q, Wang Q, Zhong Z, Yin Q, Gao M, Zhang X, Xie S
Journal of nanobiotechnology 2026 Apr 14;
Journal of nanobiotechnology 2026 Apr 14;
Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model.
Zheng M, Chen Z, Xie J, Yang Q, Mo M, Chen L
International journal of nanomedicine 2025;20:5799-5815
International journal of nanomedicine 2025;20:5799-5815
Single-Cell RNA Sequencing Reveals Microglial Heterogeneity and Functional States After Cerebral Ischemia-Reperfusion Injury.
Tang Y, Zhang Q, Qu Y, Yi L, Li F, Qu C, Shi S, Pan BF, Wen S, Sun R, Pan Y
Journal of inflammation research 2025;18:16931-16956
Journal of inflammation research 2025;18:16931-16956
Dexmedetomidine alleviates lung ischemia-reperfusion injury by inhibiting cuproptosis: an in vivo study.
Liu H, Wang Z, Qiu T, Du W, Wu Z, Chen S, Jiao W
Frontiers in pharmacology 2025;16:1562535
Frontiers in pharmacology 2025;16:1562535
Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer.
Peng F, Chen X, Wu L, He J, Li Z, Hong Q, Zhao Q, Qian M, Wang X, Shen W, Qi T, Huang Y, Cai G, Zhang C, Chen X
Theranostics 2025;15(11):5499-5517
Theranostics 2025;15(11):5499-5517
Knockdown of ACC1 promotes migration and invasion of U251 glioma cells by epigenetically suppressing SDH.
Wei X, Wang Y, Zhao W, Yang W, Tang J, Zhao B, Liu Y
International journal of oncology 2025 Sep;67(3)
International journal of oncology 2025 Sep;67(3)
Hexokinase-2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming.
Jiang D, Sun Y, Yu X, Wang R, Zhang Y, Yu J, Xie S, Cai Y, Luo Y, Chen W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03690
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03690
C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer.
Liu R, Zhao M, Zhang X, Wu H, Ren L, Lv J, Liu Z, Wang Q, Yao Z
Cell reports 2025 Sep 23;44(9):116163
Cell reports 2025 Sep 23;44(9):116163
FGL2-induced metabolic dysregulation in enteric neural crest cells provides insight into Hirschsprung disease pathogenesis.
Han J, Liu X, Wang Y, Xu Q, Sun D, Zhang X, He X, Ma C, Ren X, Wang J, Mou Y, Zhang Q, Wang D, Mu W, Hou P, Li A
iScience 2025 Sep 19;28(9):113423
iScience 2025 Sep 19;28(9):113423
A galacturonan from sea buckthorn (Hippophae rhamnoides L.) berry modulates dyslipidemia by promoting hepatic lipolysis and mitochondrial oxidation.
Sun Y, Ni W, Wang D, Ren J, Zhao D, Yu S, Liu S, Zhang S, Wang S, Wang W, Liu M
Carbohydrate polymers 2025 Sep 1;363:123708
Carbohydrate polymers 2025 Sep 1;363:123708
Iron overload exaggerates renal ischemia-reperfusion injury by promoting tubular cuproptosis via interrupting function of LIAS.
Chen S, Chen T, Xu C, Yu X, Shi J, Yang C, Zhu T
Redox biology 2025 Oct;86:103795
Redox biology 2025 Oct;86:103795
Mitochondrial electron transport chain gene-based prognostic model identifies SDHB as a key regulator of low-grade glioma progression and therapeutic target.
Li Y, Liu Q, Su J, Jiang L, Li Z, Peng H
Cancer cell international 2025 Oct 8;25(1):343
Cancer cell international 2025 Oct 8;25(1):343
SIRT7 drives energy metabolic shifts in endometriosis via interaction with TUFM and Rhoa/Rock/Akt pathway activation.
Zhang H, Chen J, Yang M, Ding X, Chai G, Huang R, Lin D, Huang Z, Chen Q
Cellular and molecular life sciences : CMLS 2025 Oct 30;82(1):381
Cellular and molecular life sciences : CMLS 2025 Oct 30;82(1):381
Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male mice.
Wang X, Xiong X, Xuan Y, Tian W, Chen L, Chen Z, Zhang Y, Shen WL, Hu C
Molecular biomedicine 2025 Oct 2;6(1):75
Molecular biomedicine 2025 Oct 2;6(1):75
Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer.
Silva L, Skiados N, Murugavel N, Cover K, Luna N, Gupta MK, Contreras SC, O'Brien TE, Zhang WC
Cancer cell international 2025 Oct 17;25(1):362
Cancer cell international 2025 Oct 17;25(1):362
FXR suppress Müller cell activation by regulating cGAS/STING pathway in diabetic retinopathy.
Wang ZL, Zhang XY, Tan CY, Zhuang M, Zhu L, Zheng XH, Yao Y, Wei TT
The FEBS journal 2025 Nov;292(22):6035-6053
The FEBS journal 2025 Nov;292(22):6035-6053
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Qi H, Sun L, Chai J, Ma J, Yu H, Xia M, Hu X
Experimental eye research 2025 Nov;260:110582
Experimental eye research 2025 Nov;260:110582
Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death.
Jain C, Essani M, Kumar R, Das NK, Singhal R, Rossiter NJ, Chen B, Huang W, Lee ZH, Solanki S, Zhang Y, Sajjakulnukit P, Zhang L, Dalal PJ, Hanna DA, McCollum S, Stoffel EM, Greenson JK, Maher LJ, Lyssiotis CA, Banerjee R, Shah YM
bioRxiv : the preprint server for biology 2025 Nov 6;
bioRxiv : the preprint server for biology 2025 Nov 6;
Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson's Disease.
Wen Y, Han Z, Wang B, Feng C, Ding X, Li Y, Lv Y, Wang X, Gao L
Cellular and molecular neurobiology 2025 May 29;45(1):53
Cellular and molecular neurobiology 2025 May 29;45(1):53
Selenoprotein K Confers Protection against Iron Dyshomeostasis-Related Neurotoxicity by Regulating the Palmitoylation of TfR-1.
Jia SZ, Li Y, Xu XW, Huang YP, Deng XY, Zhang ZH, Song GL
Journal of agricultural and food chemistry 2025 May 21;73(20):12233-12246
Journal of agricultural and food chemistry 2025 May 21;73(20):12233-12246
Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging.
Jiang D, Li K, Sun Y, Zhang Z, Xie S, Yu X, Wang R, Feng Y, Zheng Q, Wen Y, Reinach PS, Du Y, Zhou M, Chen W
Genome medicine 2025 May 19;17(1):56
Genome medicine 2025 May 19;17(1):56
Effects of polystyrene microparticles exposures on spermatogenic cell differentiation and reproductive endpoints in male mice.
Shen R, Xia P, Guo Y, Ji P, Yuan X, Wang L, Shuang S, Zhou L, Tong R, Zhang L, Liu D, Wang D
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126200
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126200
Impact of POU3F4 mutation on cochlear development and auditory function.
Dang J, Bian P, Chen C, Chen C, Shan W, Cai L, Li Y, Tan H, Xu B, Guan M, Guo Y
Cell communication and signaling : CCS 2025 Mar 5;23(1):121
Cell communication and signaling : CCS 2025 Mar 5;23(1):121
Isolated Mitochondrial Transplantation as a Novel Treatment for Corneal Chemical Burns.
Jiang D, Yu J, Wu X, Yu X, Jin P, Zheng H, Liu H, Xu W, Lian Q, Chen W
Investigative ophthalmology & visual science 2025 Mar 3;66(3):14
Investigative ophthalmology & visual science 2025 Mar 3;66(3):14
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
Fang X, Zhong Y, Zheng R, Wu Q, Liu Y, Zhang D, Wang Y, Ding W, Wang K, Zhong F, Lin K, Yao X, Hu Q, Li X, Xu G, Liu N, Nie J, Li D, Geng H, Guan Y
Science advances 2025 Mar 21;11(12):eadr8648
Science advances 2025 Mar 21;11(12):eadr8648
Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration.
Chen X, Zhou Y, Yao W, Gao C, Sha Z, Yi J, Wang J, Liu X, Dai C, Zhang Y, Wu Z, Yao X, Zhou J, Liu H, Chen Y, Ouyang H
Bone research 2025 Mar 17;13(1):37
Bone research 2025 Mar 17;13(1):37
The mitochondrial protease ClpP is a promising target for multiple myeloma treatment.
Liu X, Gu J, Liu S, Huang J, Li L, Wang F, He S, Mi Z, Zhang Y, Wen J, Gao Q, Yang H, Feng Y, Luo H, Zhai X, Zhang L, Zheng Y, Luo Y, Niu T
Biochemical pharmacology 2025 Jun;236:116855
Biochemical pharmacology 2025 Jun;236:116855
TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3.
Qu Y, Wang X, Li J, Luo H, Liu H, Wang T, Han X
International immunopharmacology 2025 Jun 26;159:114947
International immunopharmacology 2025 Jun 26;159:114947
Targeted Reprogramming of Macrophages by Nanozyme for Accelerated Wound Healing.
Feng H, Liu E, Gao N, Qiu Y, Zhou Z, Tian H, Wang Y
ACS applied materials & interfaces 2025 Jun 25;17(25):36356-36365
ACS applied materials & interfaces 2025 Jun 25;17(25):36356-36365
MitCOM-based prognostic model identifies GLUD1 as a key suppressor of glioblastoma growth and invasion through regulation of mitochondrial structure and metabolism.
Li Y, Qin C, Jiang L, Su J, Li Z, Liu Q, Yao Y
Cancer cell international 2025 Jun 21;25(1):222
Cancer cell international 2025 Jun 21;25(1):222
Corticosterone induces fatty liver syndrome in chickens via glucocorticoid receptor and inhibition of mitochondrial supercomplex formation.
Chen H, Zhang K, Yu H, Guan Z, Zhao R, Wu L
American journal of physiology. Regulatory, integrative and comparative physiology 2025 Jun 1;328(6):R770-R782
American journal of physiology. Regulatory, integrative and comparative physiology 2025 Jun 1;328(6):R770-R782
Astroglial membrane camouflaged Ptbp1 siRNA delivery hinders glutamate homeostasis via SDH/Nrf2 pathway.
Liu Y, Ren J, Zhang W, Ding L, Ma R, Zhang M, Zheng S, Liang R, Zhang Y
Biomaterials 2025 Jan;312:122707
Biomaterials 2025 Jan;312:122707
Impaired Iron-Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy.
Wang M, Zhang S, Tian J, Yang F, Chen H, Bai S, Kang J, Pang K, Huang J, Dong M, Dong S, Tian Z, Fang S, Fan H, Lu F, Yu B, Li S, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2406695
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2406695
hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling.
Yang M, Chen X, Zhang M, Zhang X, Xiao D, Xu H, Lu M
Biological research 2025 Jan 27;58(1):8
Biological research 2025 Jan 27;58(1):8
Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment.
Wang L, Zou G, Yan Y, Shi R, Guo Y, Zhang M, Lu L, Dong K
Investigative ophthalmology & visual science 2025 Jan 2;66(1):17
Investigative ophthalmology & visual science 2025 Jan 2;66(1):17
Endothelial FUNDC1 Deficiency Drives Pulmonary Hypertension.
Pei Y, Ren D, Yin Y, Shi J, Ai Q, Hao W, Luo X, Zhang C, Zhao Y, Bai C, Zhu L, Wang Q, Li S, Zhang Y, Lu J, Liu L, Zhou L, Wu Y, Weng Y, Jing Y, Lu C, Cui Y, Zheng H, Li Y, Chen G, Hu G, Chen Q, Liao X
Circulation research 2025 Jan 17;136(2):e1-e19
Circulation research 2025 Jan 17;136(2):e1-e19
Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse.
Cheng SY, Yang YF, Wang YL, Yue ZP, Chen YZ, Wang WK, Xu ZR, Li LF, Shen H, Qi ZM, Xu CL, Liu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115201
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115201
Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.
Song J, Yang M, Xia L, Wang L, Wang K, Xiang Y, Cheng J, Chen J, Liu J, Zhao R, Liu F, Sun Z, Hou X, Zang N, Chen L
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13717
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13717
Drosophila modeling to identify causative genes and reveal the underlying molecular mechanisms for primary ovarian insufficiency.
Ma Y, Liu Y, Xu M, Yin X, Hu C, Yang X, Ge W
Journal of molecular medicine (Berlin, Germany) 2025 Feb;103(2):239-253
Journal of molecular medicine (Berlin, Germany) 2025 Feb;103(2):239-253
SRF/SLC31A1 signaling promotes cuproptosis induced by celastrol in NSCLC.
Xue R, Qin C, Li L, Huang L, Tang K, Chen J, Liang H, Xu H, Qin X, Yang C, Tan Q
International immunopharmacology 2025 Feb 20;148:114165
International immunopharmacology 2025 Feb 20;148:114165
MDPAO1 peptide from human milk enhances brown adipose tissue thermogenesis and mitigates obesity.
Gao Y, Zhang J, Cao M, Zhang Y, Cao M, Gu W, Wang M
Molecular and cellular endocrinology 2025 Feb 1;597:112443
Molecular and cellular endocrinology 2025 Feb 1;597:112443
NAD(+) Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT.
Song J, Sun Y, Zang N, Liu X, Chen J, Wang K, Xia L, Chen J, Zhao R, Liu F, Hou X, Chen L, Cheng J, Zhang W
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70142
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70142
Darunavir analog precursors target mitochondrial metabolism in multiple myeloma and CLL.
Mecca M, Sichetti M, Spina E, Giuseffi M, Giglio E, Picerno S, Valvano L, Statuto T, Santarsiere A, Funicello M, Armentano MF, Chiummiento L, Lupattelli P, Romano A, Giordano A, Cortellino S
Cancer cell international 2025 Dec 23;26(1):44
Cancer cell international 2025 Dec 23;26(1):44
CAV2-expressing nerves induce metabolic switch toward mitochondrial oxidative phosphorylation to promote cancer stemness.
Zhang Z, Wang C, Sun Z, Shi X, Shuai Y, Wang Y, Wang Y, Guo H, Liu R, Luo J
Nature communications 2025 Dec 2;17(1):203
Nature communications 2025 Dec 2;17(1):203
Liraglutide alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by enhancing mitophagy mediated by the AMPK-Parkin signaling pathway.
Zhu YX, Zhang W, Qu HL, Zhang Y, Zhou RQ, Li P, Wang F, Zhang Y, Liu HH, Li S, Dong Q, Dou KF, Guo YL, Li JJ, Xu RX
World journal of diabetes 2025 Dec 15;16(12):112423
World journal of diabetes 2025 Dec 15;16(12):112423
CX3CL1 deficiency ameliorates acute kidney injury by inhibiting macrophage mitochondrial dysfunction and mtDNA-cGAS-STING signaling.
Gong Q, Liu F, Huang Y, Li D, Zhou T, Zeng C, Jiang Y, Wei H, Xu Y
Cell death discovery 2025 Dec 13;12(1):69
Cell death discovery 2025 Dec 13;12(1):69
Leber's hereditary optic neuropathy-associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis.
Yasheng M, Ji Y, He Y, Yi Q, Zhang H, Shan W, Wang K, Zhang J, Li Y, Meng F, Zhang M, Mo JQ, Wei S, Guan MX
The Journal of biological chemistry 2025 Aug;301(8):110464
The Journal of biological chemistry 2025 Aug;301(8):110464
Evidence that mitochondria in macrophages are destroyed by microautophagy.
Lu SL, Chen S, Noda K, Li Y, Tsai CY, Omori H, Kato Y, Zhang Z, Chen B, Tokuda K, Zheng T, Wakita M, Hara E, Fukuda M, Wada Y, Morita E, Uzawa N, Murakami S, Noda T
Nature communications 2025 Aug 30;16(1):8123
Nature communications 2025 Aug 30;16(1):8123
Succinate links TCA cycle dysfunction to inflammation by activating HIF-1α signaling in acute kidney injury.
Xu B, Zhu Z, Shu H, Wang H, Lu X, Zhu X
International immunopharmacology 2025 Aug 28;161:115105
International immunopharmacology 2025 Aug 28;161:115105
NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy.
Sun Y, Li L, Yang X, Yin S, Xiao Z
Translational psychiatry 2025 Aug 18;15(1):292
Translational psychiatry 2025 Aug 18;15(1):292
Intrauterine inflammation-induced neonatal lung injury via succinic acid-mediated alveolar epithelial E-cadherin downregulation.
Li B, Chen Z, Yao D, Li W, Zhang Q, Ni M, Shen Q, Lin Z, Cheng C, Qi S, Ding X, Zhao J, Liu Z
American journal of physiology. Lung cellular and molecular physiology 2025 Aug 1;329(2):L282-L295
American journal of physiology. Lung cellular and molecular physiology 2025 Aug 1;329(2):L282-L295
Retromer promotes the lysosomal turnover of mtDNA.
Kakanj P, Bonse M, Kshirsagar A, Gökmen A, Gaedke F, Sen A, Mollá B, Vogelsang E, Schauss A, Wodarz A, Pla-Martín D
Science advances 2025 Apr 4;11(14):eadr6415
Science advances 2025 Apr 4;11(14):eadr6415
Idebenone improves mitochondrial respiratory activity and attenuates oxidative damage via the SIRT3-SOD2 pathway in a prion disease cell model.
Sun Z, Wen P, Yang D, Li J, Li Z, Zhao M, Wang D, Gou F, Wang J, Fan Q, Dai Y, Ji Y, Li X, Tu Y, Ma T, Wang X, Zhao D, Yang L
Life sciences 2025 Apr 1;366-367:123481
Life sciences 2025 Apr 1;366-367:123481
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952
International journal of biological sciences 2024;20(3):937-952
Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.
He C, An Y, Shi L, Huang Y, Zhang H, Fu W, Wang M, Shan Z, Du Y, Xie J, Huang Z, Sun W, Zhao Y, Zhao B
Frontiers in pharmacology 2024;15:1371929
Frontiers in pharmacology 2024;15:1371929
Identification and validation of cuproptosis-related genes in acetaminophen-induced liver injury using bioinformatics analysis and machine learning.
Guo Z, Liu J, Liang G, Liang H, Zhong M, Tomlinson S, He S, Ouyang G, Yuan G
Frontiers in immunology 2024;15:1371446
Frontiers in immunology 2024;15:1371446
FDX2, an iron-sulfur cluster assembly factor, is essential to prevent cellular senescence, apoptosis or ferroptosis of ovarian cancer cells.
Miyahara S, Ohuchi M, Nomura M, Hashimoto E, Soga T, Saito R, Hayashi K, Sato T, Saito M, Yamashita Y, Shimada M, Yaegashi N, Yamada H, Tanuma N
The Journal of biological chemistry 2024 Sep;300(9):107678
The Journal of biological chemistry 2024 Sep;300(9):107678
Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity.
Zhao R, Yang J, Zhai Y, Zhang H, Zhou Y, Hong L, Yuan D, Xia R, Liu Y, Pan J, Shafi S, Shi G, Zhang R, Luo D, Yuan J, Pan D, Peng C, Li S, Sun M
Nature immunology 2024 Sep;25(9):1565-1579
Nature immunology 2024 Sep;25(9):1565-1579
Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts.
Reiter L, Niehoff N, Weiland D, Helbig D, Eming SA, Krieg T, Etich J, Brachvogel B, Wiesner RJ, Knuever J
Matrix biology : journal of the International Society for Matrix Biology 2024 Sep;132:72-86
Matrix biology : journal of the International Society for Matrix Biology 2024 Sep;132:72-86
Novel Insights Into DLAT's Role in Alzheimer's Disease-Related Copper Toxicity Through Microglial Exosome Dynamics.
Ma X, Sun Y, Li C, Wang M, Zang Q, Zhang X, Wang F, Niu Y, Hua J
CNS neuroscience & therapeutics 2024 Oct;30(10):e70064
CNS neuroscience & therapeutics 2024 Oct;30(10):e70064
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Bai J, Zhang X, Zhao Z, Sun S, Cheng W, Yu H, Chang X, Wang B
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Acrylamide Exposure Impairs Ovarian Tricarboxylic Acid Cycle and Reduces Oocyte Quality in Mouse.
Liu YC, Li RC, Wang WK, Chen YZ, He QK, Xu ZR, Yang YF, Cheng SY, Wang HL, Qi ZQ, Xu CL, Liu Y
Environmental toxicology 2024 Nov;39(11):5074-5085
Environmental toxicology 2024 Nov;39(11):5074-5085
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model.
Du M, Fu J, Zhang J, Zhu Z, Huang X, Tan W, Liu L, Huang Z, Liu X, Tan Q, Liao Z, Cheng Y
Clinical and translational medicine 2024 Nov;14(11):e70100
Clinical and translational medicine 2024 Nov;14(11):e70100
Taurine hypomodification underlies mitochondrial tRNATrp-related genetic diseases.
Lu JL, Dai Y, Ji K, Peng GX, Li H, Yan C, Shen B, Zhou XL
Nucleic acids research 2024 Nov 27;52(21):13351-13367
Nucleic acids research 2024 Nov 27;52(21):13351-13367
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Chen YZ, Wang WK, Yang YF, Cheng SY, Li LF, Shen H, Qi ZM, Liu Y
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation.
Chen K, Ha S, Xu L, Liu C, Liu Y, Wu X, Li Z, Wu S, Yang B, Chen Z
Journal of translational medicine 2024 May 8;22(1):437
Journal of translational medicine 2024 May 8;22(1):437
Metformin induction of heat shock factor 1 activation and the mitochondrial unfolded protein response alleviate cardiac remodeling in spontaneously hypertensive rats.
Xu M, Li LP, He X, Lu XZ, Bi XY, Li Q, Xue XR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 15;38(9):e23654
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 15;38(9):e23654
Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication.
Wang H, Guo S, Gao H, Ding J, Li H, Kong X, Zhang S, He M, Feng Y, Wu W, Xu K, Chen Y, Zhang H, Liu T, Kong X
The Journal of clinical investigation 2024 Jun 18;134(16)
The Journal of clinical investigation 2024 Jun 18;134(16)
BNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC.
Wang S, Cheng H, Li M, Gao D, Wu H, Zhang S, Huang Y, Guo K
Cell death & disease 2024 Jul 5;15(7):484
Cell death & disease 2024 Jul 5;15(7):484
Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer's Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice.
Zhu Y, Huang H, Chen Z, Tao Y, Liao LY, Gao SH, Wang YJ, Gao CY
Neuroscience bulletin 2024 Feb;40(2):182-200
Neuroscience bulletin 2024 Feb;40(2):182-200
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
He Y, Zhu G, Li X, Zhou M, Guan MX
iScience 2024 Feb 16;27(2):108883
iScience 2024 Feb 16;27(2):108883
Intervention of Tanshinone IIA on the PGK1-PDHK1 Pathway to Reprogram Macrophage Phenotype After Myocardial Infarction.
Gao S, Yang Z, Li D, Wang B, Zheng X, Li C, Fan G
Cardiovascular drugs and therapy 2024 Dec;38(6):1359-1373
Cardiovascular drugs and therapy 2024 Dec;38(6):1359-1373
Colorectal cancer cells establish metabolic reprogramming with cancer-associated fibroblasts (CAFs) through lactate shuttle to enhance invasion, migration, and angiogenesis.
Wang X, Qu Y, Ji J, Liu H, Luo H, Li J, Han X
International immunopharmacology 2024 Dec 25;143(Pt 2):113470
International immunopharmacology 2024 Dec 25;143(Pt 2):113470
TRIM24-DTNBP1-ATP7A mediated astrocyte cuproptosis in cognition and memory dysfunction caused by Y(2)O(3) NPs.
Chen Z, Liu J, Zheng M, Mo M, Hu X, Liu C, Pathak JL, Wang L, Chen L
The Science of the total environment 2024 Dec 1;954:176353
The Science of the total environment 2024 Dec 1;954:176353
mTORC1 Signaling Inhibition Modulates Mitochondrial Function in Frataxin Deficiency.
Lehmer M, Zoncu R
bioRxiv : the preprint server for biology 2024 Aug 7;
bioRxiv : the preprint server for biology 2024 Aug 7;
Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling.
Song J, Wang L, Wang L, Guo X, He Q, Cui C, Hu H, Zang N, Yang M, Yan F, Liang K, Wang C, Liu F, Sun Y, Sun Z, Lai H, Hou X, Chen L
Stem cells translational medicine 2024 Aug 16;13(8):776-790
Stem cells translational medicine 2024 Aug 16;13(8):776-790
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Huang Y, Jiang C, Li X, Liu S, Niu Y, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides.
Schofield JH, Longo J, Sheldon RD, Albano E, Ellis AE, Hawk MA, Murphy S, Duong L, Rahmy S, Lu X, Jones RG, Schafer ZT
Cell reports 2024 Apr 23;43(4):113984
Cell reports 2024 Apr 23;43(4):113984
Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity.
Zhang Z, Li P, Chen Y, Chen Y, Wang X, Shen S, Zhao Y, Zhu Y, Wang T
Cell communication and signaling : CCS 2024 Apr 2;22(1):210
Cell communication and signaling : CCS 2024 Apr 2;22(1):210
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Chen ZL, Guo C, Zou YY, Feng C, Yang DX, Sun CC, Wen W, Jian ZJ, Zhao Z, Xiao Q, Zheng L, Peng XY, Zhou ZQ, Tang CF
Experimental gerontology 2023 Sep;180:112265
Experimental gerontology 2023 Sep;180:112265
TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy.
Li Y, Zhu L, Cai MX, Wang ZL, Zhuang M, Tan CY, Xie TH, Yao Y, Wei TT
Cell death & disease 2023 Sep 1;14(9):583
Cell death & disease 2023 Sep 1;14(9):583
Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
Li X, Wu F, Günther S, Looso M, Kuenne C, Zhang T, Wiesnet M, Klatt S, Zukunft S, Fleming I, Poschet G, Wietelmann A, Atzberger A, Potente M, Yuan X, Braun T
Nature 2023 Oct;622(7983):619-626
Nature 2023 Oct;622(7983):619-626
Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway.
Li HY, Wei TT, Zhuang M, Tan CY, Xie TH, Cai J, Yao Y, Zhu L
Cell death discovery 2023 Nov 18;9(1):419
Cell death discovery 2023 Nov 18;9(1):419
A mitochondrial iron-responsive pathway regulated by DELE1.
Sekine Y, Houston R, Eckl EM, Fessler E, Narendra DP, Jae LT, Sekine S
Molecular cell 2023 Jun 15;83(12):2059-2076.e6
Molecular cell 2023 Jun 15;83(12):2059-2076.e6
Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells.
Kaur H, Minchella P, Alvarez-Carbonell D, Purandare N, Nagampalli VK, Blankenberg D, Hulgan T, Gerschenson M, Karn J, Aras S, Kallianpur AR
International journal of molecular sciences 2023 Jul 31;24(15)
International journal of molecular sciences 2023 Jul 31;24(15)
A high-fat diet increases hepatic mitochondrial turnover through restricted acetylation in a NAFLD mouse model.
Aghayev M, Arias-Alvarado A, Ilchenko S, Lepp J, Scott I, Chen YR, Zhang GF, Tsai TH, Kasumov T
American journal of physiology. Endocrinology and metabolism 2023 Jul 1;325(1):E83-E98
American journal of physiology. Endocrinology and metabolism 2023 Jul 1;325(1):E83-E98
Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation.
Reynolds MB, Hong HS, Michmerhuizen BC, Lawrence AE, Zhang L, Knight JS, Lyssiotis CA, Abuaita BH, O'Riordan MX
Science advances 2023 Feb 3;9(5):eade8701
Science advances 2023 Feb 3;9(5):eade8701
Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.
Liu Y, Liu K, Thorne RF, Shi R, Zhang Q, Wu M, Liu L
Cell reports 2023 Feb 28;42(2):112041
Cell reports 2023 Feb 28;42(2):112041
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Guo Q, Ma M, Yu H, Han Y, Zhang D
Annals of medicine 2023 Dec;55(1):2209735
Annals of medicine 2023 Dec;55(1):2209735
Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation.
Wang J, Ji Y, Ai C, Chen JR, Gan D, Zhang J, Mo JQ, Guan MX
Journal of biomedical science 2023 Aug 3;30(1):63
Journal of biomedical science 2023 Aug 3;30(1):63
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.
Li MX, Wu XT, Jing WQ, Hou WK, Hu S, Yan W
Cell death & disease 2023 Aug 2;14(8):492
Cell death & disease 2023 Aug 2;14(8):492
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
Sun MX, Qiao FX, Xu ZR, Liu YC, Xu CL, Wang HL, Qi ZQ, Liu Y
Free radical biology & medicine 2023 Aug 1;204:313-324
Free radical biology & medicine 2023 Aug 1;204:313-324
5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration.
Lee JJ, Chang-Chien GP, Lin S, Hsiao YT, Ke MC, Chen A, Lin TK
Oxidative medicine and cellular longevity 2022;2022:1792894
Oxidative medicine and cellular longevity 2022;2022:1792894
Claudin-10 overexpression suppresses human clear cell renal cell carcinoma growth and metastasis by regulating ATP5O and causing mitochondrial dysfunction.
Yang W, Zhang K, Zhang Z, Zhou J, Li L, Xu Y, Qiu J, Cai L, Gong Y, Gong K
International journal of biological sciences 2022;18(6):2329-2344
International journal of biological sciences 2022;18(6):2329-2344
CHCHD10 Modulates Thermogenesis of Adipocytes by Regulating Lipolysis.
Ding M, Ma YJ, Du RQ, Zhou WY, Dou X, Yang QQ, Tang Y, Qian SW, Liu Y, Pan DN, Tang QQ, Liu Y
Diabetes 2022 Sep 1;71(9):1862-1879
Diabetes 2022 Sep 1;71(9):1862-1879
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.
Yuan M, Wang Y, Wen J, Jing F, Zou Q, Pu Y, Pan T, Cai Z
Aging and disease 2022 Oct 1;13(5):1532-1545
Aging and disease 2022 Oct 1;13(5):1532-1545
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Sun LY, Lyu YY, Zhang HY, Shen Z, Lin GQ, Geng N, Wang YL, Huang L, Feng ZH, Guo X, Lin N, Ding S, Yuan AC, Zhang L, Qian K, Pu J
Circulation 2022 Nov 22;146(21):1591-1609
Circulation 2022 Nov 22;146(21):1591-1609
Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.
Lan B, Zhao H, He Y, Zhao Z, Wang N, Gao Y
Experimental cell research 2022 Nov 15;420(2):113358
Experimental cell research 2022 Nov 15;420(2):113358
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia-reperfusion injure by restoring CPT1A mediated fatty acid oxidation.
Gao Z, Zhang C, Peng F, Chen Q, Zhao Y, Chen L, Wang X, Chen X
Stem cell research & therapy 2022 May 7;13(1):191
Stem cell research & therapy 2022 May 7;13(1):191
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Shen R, Yang K, Cheng X, Guo C, Xing X, Sun H, Liu D, Liu X, Wang D
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3.
Zhang Q, Ren J, Wang F, Pan M, Cui L, Li M, Qu F
Free radical biology & medicine 2022 Jul;187:1-16
Free radical biology & medicine 2022 Jul;187:1-16
Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells.
Zhu S, Wang W, Zhang J, Ji S, Jing Z, Chen YQ
Cellular & molecular biology letters 2022 Feb 2;27(1):11
Cellular & molecular biology letters 2022 Feb 2;27(1):11
Yiqi Huoxue Tongluo recipe regulates NR4A1 to improve renal mitochondrial function in unilateral ureteral obstruction (UUO) rats.
He Z, Zhang M, Xu H, Zhou W, Xu C, Wang Z, He M, Wang X
Pharmaceutical biology 2022 Dec;60(1):2308-2318
Pharmaceutical biology 2022 Dec;60(1):2308-2318
Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death.
Liu WJ, Pan PY, Sun Y, Wang JB, Zhou H, Xie X, Duan ZY, Dong HY, Chen WN, Zhang LD, Wang C
Frontiers in oncology 2021;11:794735
Frontiers in oncology 2021;11:794735
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.
Fu F, Liu C, Shi R, Li M, Zhang M, Du Y, Wang Q, Li J, Wang G, Pei J, Ding M
Antioxidants & redox signaling 2021 Sep;35(8):618-641
Antioxidants & redox signaling 2021 Sep;35(8):618-641
Imatinib Regulates miR-483-3p and Mitochondrial Respiratory Complexes in Gastrointestinal Stromal Tumors.
Huang WK, Shi H, Akçakaya P, Zeljic K, Gangaev A, Caramuta S, Yeh CN, Bränström R, Larsson C, Lui WO
International journal of molecular sciences 2021 Sep 30;22(19)
International journal of molecular sciences 2021 Sep 30;22(19)
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.
Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nature communications 2021 Jun 8;12(1):3428
Nature communications 2021 Jun 8;12(1):3428
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells.
Schwartz AJ, Goyert JW, Solanki S, Kerk SA, Chen B, Castillo C, Hsu PP, Do BT, Singhal R, Dame MK, Lee HJ, Spence JR, Lakhal-Littleton S, Vander Heiden MG, Lyssiotis CA, Xue X, Shah YM
Nature metabolism 2021 Jul;3(7):969-982
Nature metabolism 2021 Jul;3(7):969-982
Selenium-dependent metabolic reprogramming during inflammation and resolution.
Korwar AM, Hossain A, Lee TJ, Shay AE, Basrur V, Conlon K, Smith PB, Carlson BA, Salis HM, Patterson AD, Prabhu KS
The Journal of biological chemistry 2021 Jan-Jun;296:100410
The Journal of biological chemistry 2021 Jan-Jun;296:100410
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542
The Journal of nutritional biochemistry 2021 Feb;88:108542
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Wu P, Chen J, Chen J, Tao J, Wu S, Xu G, Wang Z, Wei D, Yin W
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Jing J, Ding N, Wang D, Ge X, Ma J, Ma R, Huang X, Jueraitetibaike K, Liang K, Wang S, Cao S, Zhao AZ, Yao B
Cell death & disease 2020 Aug 14;11(8):626
Cell death & disease 2020 Aug 14;11(8):626
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, Xiao F, Guo L
Oxidative medicine and cellular longevity 2019;2019:4508762
Oxidative medicine and cellular longevity 2019;2019:4508762
Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.
Wu H, Wang Y, Li W, Chen H, Du L, Liu D, Wang X, Xu T, Liu L, Chen Q
Autophagy 2019 Nov;15(11):1882-1898
Autophagy 2019 Nov;15(11):1882-1898
A Renal Cell Carcinoma with Biallelic Somatic TSC2 Mutation: Clinical Study and Literature Review.
Pang J, Wang L, Xu J, Xie Q, Liu Q, Tong D, Liu G, Huang Y, Yang X, Pan J, Yan X, Ma Q, Zhang D, Jiang J
Urology 2019 Nov;133:96-102
Urology 2019 Nov;133:96-102
Germline SDHB and SDHD mutations in pheochromocytoma and paraganglioma patients.
Huang Y, Wang LA, Xie Q, Pang J, Wang L, Yi Y, Zhang J, Zhang Y, Chen R, Lan W, Zhang D, Jiang J
Endocrine connections 2018 Dec 1;7(12):1217-1225
Endocrine connections 2018 Dec 1;7(12):1217-1225
miR-148b-3p functions as a tumor suppressor in GISTs by directly targeting KIT.
Wang Y, Li J, Kuang D, Wang X, Zhu Y, Xu S, Chen Y, Cheng H, Zhao Q, Duan Y, Wang G
Cell communication and signaling : CCS 2018 Apr 16;16(1):16
Cell communication and signaling : CCS 2018 Apr 16;16(1):16
SDHB deficiency promotes TGFβ-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4.
Wang H, Chen Y, Wu G
Translational oncology 2016 Dec;9(6):512-520
Translational oncology 2016 Dec;9(6):512-520
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Martinez Lyons A, Ardissone A, Reyes A, Robinson AJ, Moroni I, Ghezzi D, Fernandez-Vizarra E, Zeviani M
Journal of medical genetics 2016 Dec;53(12):846-849
Journal of medical genetics 2016 Dec;53(12):846-849
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10620-1-AP(SDHB antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SDHB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SDHB. This antibody recognizes human,mouse,rat antigen. The SDHB antibody has been validated for the following applications: ELISA, WB, IHC analysis.
