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- Antibody Data
- Antigen structure
- References [33]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15965-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15965-1-AP, RRID:AB_2290472
- Product name
- BHMT antibody
- Antibody type
- Polyclonal
- Description
- BHMT antibody (Cat. #15965-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Parental betaine supplementation promotes gosling growth with epigenetic modulation of IGF gene family in the liver.
The Immunohistochemical Profile of Mammary Tissue in Women With Macromastia and Its Potential Clinical Implications.
Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice.
Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats.
In ovo injection of betaine promotes adrenal steroidogenesis in pre-hatched chicken fetuses.
The hepatic compensatory response to elevated systemic sulfide promotes diabetes.
mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.
Chronopharmacological targeting of Rev-erbα by puerarin alleviates hyperhomocysteinemia in mice.
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.
Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.
Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.
DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2-Induced Hippocampal Neurogenesis in Mice Derived From Folic-Acid-Supplemented Dams.
Homocysteine impairs porcine oocyte quality via deregulation of one-carbon metabolism and hypermethylation of mitochondrial DNA†.
Dietary betaine activates hepatic VTGII expression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression.
Dietary betaine supplementation in hens modulates hypothalamic expression of cholesterol metabolic genes in F1 cockerels through modification of DNA methylation.
Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.
Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats.
Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications.
Prenatal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in cockerels through modifications of DNA methylation.
Maternal betaine supplementation in rats induces intergenerational changes in hepatic IGF-1 expression and DNA methylation.
Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.
Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.
Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification.
Downregulation of miR-150 Expression by DNA Hypermethylation Is Associated with High 2-Hydroxy-(4-methylthio)butanoic Acid-Induced Hepatic Cholesterol Accumulation in Nursery Piglets.
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.
In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks.
Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.
Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.
Ma S, Wang Y, Chen L, Wang W, Zhuang X, Liu Y, Zhao R
Journal of animal science 2024 Jan 3;102
Journal of animal science 2024 Jan 3;102
The Immunohistochemical Profile of Mammary Tissue in Women With Macromastia and Its Potential Clinical Implications.
Antoszewski B, Kasielska-Trojan A, Jones TE, Danilewicz M, Jones MW
Endocrinology 2024 Feb 20;165(4)
Endocrinology 2024 Feb 20;165(4)
Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice.
Li W, Jia Y, Gong Z, Dong Z, Yu F, Fu Y, Jiang C, Kong W
NPJ science of food 2023 Jul 17;7(1):36
NPJ science of food 2023 Jul 17;7(1):36
Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats.
Tanaka Y, Kawano M, Nakashima S, Yamaguchi C, Asahina M, Sakamoto M, Shirouchi B, Tashiro K, Imaizumi K, Sato M
Scientific reports 2023 Feb 21;13(1):3053
Scientific reports 2023 Feb 21;13(1):3053
In ovo injection of betaine promotes adrenal steroidogenesis in pre-hatched chicken fetuses.
Abobaker H, Omer NA, Hu Y, Idriss AA, Zhao R
Poultry science 2022 Jun;101(6):101871
Poultry science 2022 Jun;101(6):101871
The hepatic compensatory response to elevated systemic sulfide promotes diabetes.
Carter RN, Gibbins MTG, Barrios-Llerena ME, Wilkie SE, Freddolino PL, Libiad M, Vitvitsky V, Emerson B, Le Bihan T, Brice M, Su H, Denham SG, Homer NZM, Mc Fadden C, Tailleux A, Faresse N, Sulpice T, Briand F, Gillingwater T, Ahn KH, Singha S, McMaster C, Hartley RC, Staels B, Gray GA, Finch AJ, Selman C, Banerjee R, Morton NM
Cell reports 2021 Nov 9;37(6):109958
Cell reports 2021 Nov 9;37(6):109958
mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.
Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I
Molecular cell 2021 May 20;81(10):2076-2093.e9
Molecular cell 2021 May 20;81(10):2076-2093.e9
Chronopharmacological targeting of Rev-erbα by puerarin alleviates hyperhomocysteinemia in mice.
Chen M, Zhou C, Xu H, Zhang T, Wu B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109936
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109936
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
Yang S, Zhao N, Sun B, Yang Y, Hu Y, Zhao R
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494
Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.
Omer NA, Hu Y, Idriss AA, Abobaker H, Hou Z, Yang S, Ma W, Zhao R
Poultry science 2020 Jun;99(6):3121-3132
Poultry science 2020 Jun;99(6):3121-3132
Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.
Hu Y, Feng Y, Ding Z, Lv L, Sui Y, Sun Q, Abobaker H, Cai D, Zhao R
Poultry science 2020 Jun;99(6):3111-3120
Poultry science 2020 Jun;99(6):3111-3120
Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
Yang Y, Jiang W, Yang S, Qi F, Zhao R
Molecular nutrition & food research 2020 Apr;64(8):e1900823
Molecular nutrition & food research 2020 Apr;64(8):e1900823
Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.
Cao Y, Ding W, Zhang J, Gao Q, Yang H, Cao W, Wang Z, Fang L, Du R
Journal of proteome research 2019 May 3;18(5):2032-2044
Journal of proteome research 2019 May 3;18(5):2032-2044
DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2-Induced Hippocampal Neurogenesis in Mice Derived From Folic-Acid-Supplemented Dams.
Yang Y, Yang S, Liu J, Feng Y, Qi F, Zhao R
Molecular nutrition & food research 2019 Jun;63(12):e1801334
Molecular nutrition & food research 2019 Jun;63(12):e1801334
Homocysteine impairs porcine oocyte quality via deregulation of one-carbon metabolism and hypermethylation of mitochondrial DNA†.
Jia L, Zeng Y, Hu Y, Liu J, Yin C, Niu Y, Wang C, Li J, Jia Y, Hong J, Zhao R
Biology of reproduction 2019 Apr 1;100(4):907-916
Biology of reproduction 2019 Apr 1;100(4):907-916
Dietary betaine activates hepatic VTGII expression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression.
Omer NA, Hu Y, Hu Y, Idriss AA, Abobaker H, Hou Z, Dong H, Zhao R
Journal of animal science and biotechnology 2018;9:2
Journal of animal science and biotechnology 2018;9:2
Dietary betaine supplementation in hens modulates hypothalamic expression of cholesterol metabolic genes in F1 cockerels through modification of DNA methylation.
Idriss AA, Hu Y, Hou Z, Hu Y, Sun Q, Omer NA, Abobaker H, Ni Y, Zhao R
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Mar;217:14-20
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Mar;217:14-20
Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Yang S, Zhao N, Yang Y, Hu Y, Dong H, Zhao R
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713
Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.
Hu Y, Sun Q, Hu Y, Hou Z, Zong Y, Omer NA, Abobaker H, Zhao R
The Journal of nutrition 2018 Mar 1;148(3):316-325
The Journal of nutrition 2018 Mar 1;148(3):316-325
Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats.
Zhao N, Yang S, Jia Y, Sun B, He B, Zhao R
The Journal of nutritional biochemistry 2018 Apr;54:105-112
The Journal of nutritional biochemistry 2018 Apr;54:105-112
Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications.
Hou Z, Sun Q, Hu Y, Yang S, Zong Y, Zhao R
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Apr;218:30-36
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 Apr;218:30-36
Prenatal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in cockerels through modifications of DNA methylation.
Idriss AA, Hu Y, Sun Q, Jia L, Jia Y, Omer NA, Abobaker H, Zhao R
Poultry science 2017 Jun 1;96(6):1715-1724
Poultry science 2017 Jun 1;96(6):1715-1724
Maternal betaine supplementation in rats induces intergenerational changes in hepatic IGF-1 expression and DNA methylation.
Zhao N, Yang S, Hu Y, Dong H, Zhao R
Molecular nutrition & food research 2017 Aug;61(8)
Molecular nutrition & food research 2017 Aug;61(8)
Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.
Yang Y, Li X, Sun Q, He B, Jia Y, Cai D, Zhao R
The international journal of biochemistry & cell biology 2016 Oct;79:222-230
The international journal of biochemistry & cell biology 2016 Oct;79:222-230
Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.
Qin S, Zhou Y, Gray L, Kusebauch U, McEvoy L, Antoine DJ, Hampson L, Park KB, Campbell D, Caballero J, Glusman G, Yan X, Kim TK, Yuan Y, Wang K, Rowen L, Moritz RL, Omenn GS, Pirmohamed M, Hood L
Journal of proteome research 2016 Oct 7;15(10):3724-3740
Journal of proteome research 2016 Oct 7;15(10):3724-3740
Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification.
Cai D, Yuan M, Liu H, Pan S, Ma W, Hong J, Zhao R
Nutrients 2016 Oct 18;8(10)
Nutrients 2016 Oct 18;8(10)
Downregulation of miR-150 Expression by DNA Hypermethylation Is Associated with High 2-Hydroxy-(4-methylthio)butanoic Acid-Induced Hepatic Cholesterol Accumulation in Nursery Piglets.
Jia Y, Ling M, Zhang L, Jiang S, Sha Y, Zhao R
Journal of agricultural and food chemistry 2016 Oct 12;64(40):7530-7539
Journal of agricultural and food chemistry 2016 Oct 12;64(40):7530-7539
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.
Jia L, Li J, He B, Jia Y, Niu Y, Wang C, Zhao R
Scientific reports 2016 Jan 13;6:19436
Scientific reports 2016 Jan 13;6:19436
In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks.
Hu Y, Sun Q, Li X, Wang M, Cai D, Li X, Zhao R
PloS one 2015;10(4):e0122643
PloS one 2015;10(4):e0122643
Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.
Li X, Sun Q, Li X, Cai D, Sui S, Jia Y, Song H, Zhao R
European journal of nutrition 2015 Oct;54(7):1201-10
European journal of nutrition 2015 Oct;54(7):1201-10
Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.
Jia Y, Song H, Gao G, Cai D, Yang X, Zhao R
Journal of agricultural and food chemistry 2015 Nov 25;63(46):10152-60
Journal of agricultural and food chemistry 2015 Nov 25;63(46):10152-60
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
Cai D, Jia Y, Song H, Sui S, Lu J, Jiang Z, Zhao R
PloS one 2014;9(8):e105504
PloS one 2014;9(8):e105504
Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.
Wang Y, Kou Y, Wang X, Cederbaum A, Wang R
PloS one 2014;9(3):e92504
PloS one 2014;9(3):e92504
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human kidney tissue were subjected to SDS PAGE followed by western blot with 15965-1-AP(BHMT antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 15965-1-AP(BHMT antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BHMT antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BHMT. This antibody recognizes human antigen. The BHMT antibody has been validated for the following applications: ELISA, WB, IHC analysis.
