Antibody data
- Antibody Data
- Antigen structure
- References [31]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 14742-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14742-1-AP, RRID:AB_2241442
- Product name
- UQCRC2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UQCRC2 antibody (Cat. #14742-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.
Imatinib Regulates miR-483-3p and Mitochondrial Respiratory Complexes in Gastrointestinal Stromal Tumors.
Structure and assembly of the mammalian mitochondrial supercomplex CIII2CIV.
Single-cell analysis reveals androgen receptor regulates the ER-to-Golgi trafficking pathway with CREB3L2 to drive prostate cancer progression.
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.
Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I.
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1.
Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder.
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca2+ Homeostasis, and Bcl2 Expression.
Analyzing electron transport chain supercomplexes.
Functional role of respiratory supercomplexes in mice: SCAF1 relevance and segmentation of the Qpool.
Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish.
NCLX prevents cell death during adrenergic activation of the brown adipose tissue.
A novel approach to measure mitochondrial respiration in frozen biological samples.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Romo1 is involved in the immune response of glioblastoma by regulating the function of macrophages.
Mitochondria in Embryogenesis: An Organellogenesis Perspective.
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy.
A Novel Tumor-Suppressor, CDH18, Inhibits Glioma Cell Invasiveness Via UQCRC2 and Correlates with the Prognosis of Glioma Patients.
Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.
Glutathione Reduction of Patulin-Evoked Cytotoxicity in HEK293 Cells by the Prevention of Oxidative Damage and the Mitochondrial Apoptotic Pathway.
CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization.
Mechanism of super-assembly of respiratory complexes III and IV.
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.
Fu F, Liu C, Shi R, Li M, Zhang M, Du Y, Wang Q, Li J, Wang G, Pei J, Ding M
Antioxidants & redox signaling 2021 Sep;35(8):618-641
Antioxidants & redox signaling 2021 Sep;35(8):618-641
Imatinib Regulates miR-483-3p and Mitochondrial Respiratory Complexes in Gastrointestinal Stromal Tumors.
Huang WK, Shi H, Akçakaya P, Zeljic K, Gangaev A, Caramuta S, Yeh CN, Bränström R, Larsson C, Lui WO
International journal of molecular sciences 2021 Sep 30;22(19)
International journal of molecular sciences 2021 Sep 30;22(19)
Structure and assembly of the mammalian mitochondrial supercomplex CIII2CIV.
Vercellino I, Sazanov LA
Nature 2021 Oct;598(7880):364-367
Nature 2021 Oct;598(7880):364-367
Single-cell analysis reveals androgen receptor regulates the ER-to-Golgi trafficking pathway with CREB3L2 to drive prostate cancer progression.
Hu L, Chen X, Narwade N, Lim MGL, Chen Z, Tennakoon C, Guan P, Chan UI, Zhao Z, Deng M, Xu X, Sung WK, Cheung E
Oncogene 2021 Nov;40(47):6479-6493
Oncogene 2021 Nov;40(47):6479-6493
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.
Chella Krishnan K, Vergnes L, Acín-Pérez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Péterfy M, Romanoski CE, Reue K, Björkegren JLM, Laakso M, Liesa M, Lusis AJ
Nature metabolism 2021 Nov;3(11):1552-1568
Nature metabolism 2021 Nov;3(11):1552-1568
Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I.
Jain S, Hu C, Kluza J, Ke W, Tian G, Giurgiu M, Bleilevens A, Campos AR, Charbono A, Stickeler E, Maurer J, Holinski-Feder E, Vaisburg A, Bureik M, Luo G, Marchetti P, Cheng Y, Wolf DA
Cell chemical biology 2021 Nov 23;
Cell chemical biology 2021 Nov 23;
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J
eLife 2021 May 26;10
eLife 2021 May 26;10
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Shi M, Huang XY, Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY, Lin SC
Nature cell biology 2021 Mar;23(3):268-277
Nature cell biology 2021 Mar;23(3):268-277
AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1.
Xiao L, Liu J, Sun Z, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T, Zhou W, Zhu Y, Chen XW, Li JZ, Chen S, Xie X, Gan Z
PLoS genetics 2021 Mar;17(3):e1009488
PLoS genetics 2021 Mar;17(3):e1009488
Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder.
Jiang W, Jia N, Guo C, Wen J, Wu L, Ogi T, Zhang H
Biochimica et biophysica acta. Molecular basis of disease 2021 Jun 1;1867(6):166106
Biochimica et biophysica acta. Molecular basis of disease 2021 Jun 1;1867(6):166106
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827
EMBO reports 2021 Jan 7;22(1):e50827
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542
The Journal of nutritional biochemistry 2021 Feb;88:108542
Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca2+ Homeostasis, and Bcl2 Expression.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Zhang Y, Peng X
Molecular nutrition & food research 2021 Aug;65(15):e2001202
Molecular nutrition & food research 2021 Aug;65(15):e2001202
Analyzing electron transport chain supercomplexes.
Acín-Pérez R, Hernansanz-Agustín P, Enríquez JA
Methods in cell biology 2020;155:181-197
Methods in cell biology 2020;155:181-197
Functional role of respiratory supercomplexes in mice: SCAF1 relevance and segmentation of the Qpool.
Calvo E, Cogliati S, Hernansanz-Agustín P, Loureiro-López M, Guarás A, Casuso RA, García-Marqués F, Acín-Pérez R, Martí-Mateos Y, Silla-Castro JC, Carro-Alvarellos M, Huertas JR, Vázquez J, Enríquez JA
Science advances 2020 Jun;6(26):eaba7509
Science advances 2020 Jun;6(26):eaba7509
Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish.
García-Poyatos C, Cogliati S, Calvo E, Hernansanz-Agustín P, Lagarrigue S, Magni R, Botos M, Langa X, Amati F, Vázquez J, Mercader N, Enríquez JA
EMBO reports 2020 Jul 3;21(7):e50287
EMBO reports 2020 Jul 3;21(7):e50287
NCLX prevents cell death during adrenergic activation of the brown adipose tissue.
Assali EA, Jones AE, Veliova M, Acín-Pérez R, Taha M, Miller N, Shum M, Oliveira MF, Las G, Liesa M, Sekler I, Shirihai OS
Nature communications 2020 Jul 3;11(1):3347
Nature communications 2020 Jul 3;11(1):3347
A novel approach to measure mitochondrial respiration in frozen biological samples.
Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS
The EMBO journal 2020 Jul 1;39(13):e104073
The EMBO journal 2020 Jul 1;39(13):e104073
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Romo1 is involved in the immune response of glioblastoma by regulating the function of macrophages.
Sun G, Cao Y, Qian C, Wan Z, Zhu J, Guo J, Shi L
Aging 2020 Jan 16;12(2):1114-1127
Aging 2020 Jan 16;12(2):1114-1127
Mitochondria in Embryogenesis: An Organellogenesis Perspective.
Arribat Y, Grepper D, Lagarrigue S, Richard J, Gachet M, Gut P, Amati F
Frontiers in cell and developmental biology 2019;7:282
Frontiers in cell and developmental biology 2019;7:282
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
Han Y, Wu P, Wang Z, Zhang Z, Sun S, Liu J, Gong S, Gao P, Iwakuma T, Molina-Vila MA, Chen BP, Zhang Y, Ji T, Mo Q, Chen P, Hu J, Wang S, Zhou J, Lu H, Gao Q
EBioMedicine 2019 Feb;40:92-105
EBioMedicine 2019 Feb;40:92-105
Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy.
Latorre-Pellicer A, Lechuga-Vieco AV, Johnston IG, Hämäläinen RH, Pellico J, Justo-Méndez R, Fernández-Toro JM, Clavería C, Guaras A, Sierra R, Llop J, Torres M, Criado LM, Suomalainen A, Jones NS, Ruíz-Cabello J, Enríquez JA
Cell metabolism 2019 Dec 3;30(6):1120-1130.e5
Cell metabolism 2019 Dec 3;30(6):1120-1130.e5
A Novel Tumor-Suppressor, CDH18, Inhibits Glioma Cell Invasiveness Via UQCRC2 and Correlates with the Prognosis of Glioma Patients.
Bai YH, Zhan YB, Yu B, Wang WW, Wang L, Zhou JQ, Chen RK, Zhang FJ, Zhao XW, Duan WC, Wang YM, Liu J, Bao JJ, Zhang ZY, Liu XZ
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(4):1755-1770
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(4):1755-1770
Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.
Fu T, Xu Z, Liu L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, Zhu MS, Chen Q, Gan Z
Cell reports 2018 May 1;23(5):1357-1372
Cell reports 2018 May 1;23(5):1357-1372
Glutathione Reduction of Patulin-Evoked Cytotoxicity in HEK293 Cells by the Prevention of Oxidative Damage and the Mitochondrial Apoptotic Pathway.
Wang X, Jin C, Zhong Y, Li X, Han J, Xue W, Wu P, Xia X, Peng X
Journal of agricultural and food chemistry 2018 Jul 25;66(29):7775-7785
Journal of agricultural and food chemistry 2018 Jul 25;66(29):7775-7785
CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
Han Y, Sun S, Zhao M, Zhang Z, Gong S, Gao P, Liu J, Zhou J, Ma D, Gao Q, Wu P
Disease markers 2016;2016:3528064
Disease markers 2016;2016:3528064
Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization.
Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MC
Cell 2016 Nov 3;167(4):985-1000.e21
Cell 2016 Nov 3;167(4):985-1000.e21
Mechanism of super-assembly of respiratory complexes III and IV.
Cogliati S, Calvo E, Loureiro M, Guaras AM, Nieto-Arellano R, Garcia-Poyatos C, Ezkurdia I, Mercader N, Vázquez J, Enriquez JA
Nature 2016 Nov 24;539(7630):579-582
Nature 2016 Nov 24;539(7630):579-582
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Martinez Lyons A, Ardissone A, Reyes A, Robinson AJ, Moroni I, Ghezzi D, Fernandez-Vizarra E, Zeviani M
Journal of medical genetics 2016 Dec;53(12):846-849
Journal of medical genetics 2016 Dec;53(12):846-849
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 14742-1-AP(UQCRC2 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using UQCRC2 antibody 14742-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 14742-1-AP(UQCRC2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 14742-1-AP(UQCRC2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue