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- Antigen structure
- References [25]
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- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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- Product number
- 19950-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19950-1-AP, RRID:AB_10644155
- Product name
- GNRHR antibody
- Antibody type
- Polyclonal
- Description
- GNRHR antibody (Cat. #19950-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Evolving Acquired Vemurafenib Resistance in a BRAF V600E Mutant Melanoma PDTX Model to Reveal New Potential Targets.
Discovery of microglia gonadotropin‑releasing hormone receptor and its potential role in polycystic ovarian syndrome.
GnRH receptor mediates lipid storage in female adipocytes via AMPK pathway.
Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.
Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates.
Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.
Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure.
Impact of Physiologically Relevant Genistein Exposure at Different Time Windows on Puberty Onset and Neuroendocrine Function in Female Rats.
Studying the nature of ascending-descending-floating-sinking of Chinese medicines based on gonadotropin-releasing hormone.
Chemical profile and miscarriage prevention evaluation of Jiao-Ai Decoction, a classical traditional Chinese formula.
miR-29a/b(1) Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation.
The Effects of Zearalenone on the Localization and Expression of Reproductive Hormones in the Ovaries of Weaned Gilts.
GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes.
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.
Suitability of GnRH Receptors for Targeted Photodynamic Therapy in Head and Neck Cancers.
Novel Crizotinib-GnRH Conjugates Revealed the Significance of Lysosomal Trapping in GnRH-Based Drug Delivery Systems.
GnRH antagonist treatment of malignant adrenocortical tumors.
Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids.
Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification.
Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus-Uterus in Pubertal Female Rats.
Peptide-Drug Conjugate GnRH-Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth.
Synthesis, characterization and systematic comparison of FITC-labelled GnRH-I, -II and -III analogues on various tumour cells.
GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.
Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary.
Tóvári J, Vári-Mező D, Surguta SE, Ladányi A, Kigyós A, Cserepes M
Cells 2023 Jul 24;12(14)
Cells 2023 Jul 24;12(14)
Discovery of microglia gonadotropin‑releasing hormone receptor and its potential role in polycystic ovarian syndrome.
Wang F, Zhang Z, Han J, Zheng J, Wang X, Wang Z
Molecular medicine reports 2023 Apr;27(4)
Molecular medicine reports 2023 Apr;27(4)
GnRH receptor mediates lipid storage in female adipocytes via AMPK pathway.
Li X, Zhang X, Shen Z, Chen Z, Wang H, Zhang X
International journal of medical sciences 2022;19(9):1442-1450
International journal of medical sciences 2022;19(9):1442-1450
Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.
Fu Y, Yuan P, Zheng Y, Wei Y, Gao L, Ruan Y, Chen Y, Li P, Feng W, Zheng X
International journal of nanomedicine 2022;17:1549-1566
International journal of nanomedicine 2022;17:1549-1566
Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates.
Schuster S, Juhász É, Halmos G, Neundorf I, Gennari C, Mező G
International journal of molecular sciences 2022 May 3;23(9)
International journal of molecular sciences 2022 May 3;23(9)
Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.
Fu Y, Yuan P, Zheng Y, Gao L, Wei Y, Chen Y, Li P, Ruan Y, Zheng X, Feng W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113061
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113061
Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure.
Zheng S, Ma M, Chen Y, Li M
Basic & clinical pharmacology & toxicology 2022 Feb;130(2):240-253
Basic & clinical pharmacology & toxicology 2022 Feb;130(2):240-253
Impact of Physiologically Relevant Genistein Exposure at Different Time Windows on Puberty Onset and Neuroendocrine Function in Female Rats.
Xiong J, Tian Y, Ma G, Wang X, Shan S, Cheng G
Molecular nutrition & food research 2022 Dec;66(24):e2200486
Molecular nutrition & food research 2022 Dec;66(24):e2200486
Studying the nature of ascending-descending-floating-sinking of Chinese medicines based on gonadotropin-releasing hormone.
Yang FU, Peipei Y, Mengnan Z, Ying H, Liyuan G, Yaxin W, Xiaoke Z, Weisheng F
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Aug;42(4):546-555
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Aug;42(4):546-555
Chemical profile and miscarriage prevention evaluation of Jiao-Ai Decoction, a classical traditional Chinese formula.
Zhang M, Geng T, Jing SH, Li L, Wang K, Zhang Q, Zhang Y, Zhou SK, Gao P, Ding AW, Zhang L
Journal of pharmaceutical and biomedical analysis 2022 Aug 5;217:114832
Journal of pharmaceutical and biomedical analysis 2022 Aug 5;217:114832
miR-29a/b(1) Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation.
Guo Y, Wu Y, Shi J, Zhuang H, Ci L, Huang Q, Wan Z, Yang H, Zhang M, Tan Y, Sun R, Xu L, Wang Z, Shen R, Fei J
Frontiers in endocrinology 2021;12:636220
Frontiers in endocrinology 2021;12:636220
The Effects of Zearalenone on the Localization and Expression of Reproductive Hormones in the Ovaries of Weaned Gilts.
Wan B, Yuan X, Yang W, Jiao N, Li Y, Liu F, Liu M, Yang Z, Huang L, Jiang S
Toxins 2021 Sep 7;13(9)
Toxins 2021 Sep 7;13(9)
GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes.
Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SBZ, Trejo J, Kauffman AS, Mellon PL, Lawson MA
Scientific reports 2020 Aug 3;10(1):13063
Scientific reports 2020 Aug 3;10(1):13063
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Suo L, Chang X, Xu N, Ji H
Frontiers in endocrinology 2019;10:370
Frontiers in endocrinology 2019;10:370
Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.
Ranđelović I, Schuster S, Kapuvári B, Fossati G, Steinkühler C, Mező G, Tóvári J
International journal of molecular sciences 2019 Sep 25;20(19)
International journal of molecular sciences 2019 Sep 25;20(19)
Suitability of GnRH Receptors for Targeted Photodynamic Therapy in Head and Neck Cancers.
Pethő L, Murányi J, Pénzes K, Gurbi B, Brauswetter D, Halmos G, Csík G, Mező G
International journal of molecular sciences 2019 Oct 11;20(20)
International journal of molecular sciences 2019 Oct 11;20(20)
Novel Crizotinib-GnRH Conjugates Revealed the Significance of Lysosomal Trapping in GnRH-Based Drug Delivery Systems.
Murányi J, Varga A, Gyulavári P, Pénzes K, Németh CE, Csala M, Pethő L, Csámpai A, Halmos G, Peták I, Vályi-Nagy I
International journal of molecular sciences 2019 Nov 8;20(22)
International journal of molecular sciences 2019 Nov 8;20(22)
GnRH antagonist treatment of malignant adrenocortical tumors.
Doroszko M, Chrusciel M, Stelmaszewska J, Slezak T, Anisimowicz S, Plöckinger U, Quinkler M, Bonomi M, Wolczynski S, Huhtaniemi I, Toppari J, Rahman NA
Endocrine-related cancer 2019 Jan 1;26(1):103-117
Endocrine-related cancer 2019 Jan 1;26(1):103-117
Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids.
Lajkó E, Spring S, Hegedüs R, Biri-Kovács B, Ingebrandt S, Mező G, Kőhidai L
Beilstein journal of organic chemistry 2018;14:2495-2509
Beilstein journal of organic chemistry 2018;14:2495-2509
Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification.
Schuster S, Biri-Kovács B, Szeder B, Buday L, Gardi J, Szabó Z, Halmos G, Mező G
Pharmaceutics 2018 Nov 9;10(4)
Pharmaceutics 2018 Nov 9;10(4)
Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus-Uterus in Pubertal Female Rats.
Liu T, Jia Y, Zhou L, Wang Q, Sun D, Xu J, Wu J, Chen H, Xu F, Ye L
International journal of environmental research and public health 2016 Nov 12;13(11)
International journal of environmental research and public health 2016 Nov 12;13(11)
Peptide-Drug Conjugate GnRH-Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth.
Argyros O, Karampelas T, Asvos X, Varela A, Sayyad N, Papakyriakou A, Davos CH, Tzakos AG, Fokas D, Tamvakopoulos C
Cancer research 2016 Mar 1;76(5):1181-92
Cancer research 2016 Mar 1;76(5):1181-92
Synthesis, characterization and systematic comparison of FITC-labelled GnRH-I, -II and -III analogues on various tumour cells.
Murányi J, Gyulavári P, Varga A, Bökönyi G, Tanai H, Vántus T, Pap D, Ludányi K, Mező G, Kéri G
Journal of peptide science : an official publication of the European Peptide Society 2016 Aug;22(8):552-60
Journal of peptide science : an official publication of the European Peptide Society 2016 Aug;22(8):552-60
GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.
Karampelas T, Argyros O, Sayyad N, Spyridaki K, Pappas C, Morgan K, Kolios G, Millar RP, Liapakis G, Tzakos AG, Fokas D, Tamvakopoulos C
Bioconjugate chemistry 2014 Apr 16;25(4):813-23
Bioconjugate chemistry 2014 Apr 16;25(4):813-23
Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary.
Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E
Endocrinology 2013 Oct;154(10):3877-87
Endocrinology 2013 Oct;154(10):3877-87
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 19950-1-AP(GNRHR antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 19950-1-AP(GNRHR antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 19950-1-AP(GNRHR antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GNRHR antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human GNRHR. This antibody recognizes human, mouse antigen. The GNRHR antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
