BS8023

antibody from Bioworld Technology, Inc

Targeting: GNRHR GRHR, LHRHR

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8023

Provider

Bioworld Technology, Inc

Product name

GNRHR polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human GNRHR.

Description

Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). GnRHR2 (gonadotropin-releasing hormone (type 2) receptor 2), also known as GnRH-II-R, is a 379 amino acid multi-pass membrane protein that is expressed in a variety of tissues, where it functions as a G protein coupled receptor for GnRH. Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.