Antibody data
- Antibody Data
- Antigen structure
- References [40]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 15301-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15301-1-AP, RRID:AB_2149048
- Product name
- NDUFV2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NDUFV2 antibody (Cat. #15301-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes.
Acute endoplasmic reticulum stress-induced mitochondria respiratory chain damage: The role of activated calpains.
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat.
Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia.
SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.
The KDET Motif in the Intracellular Domain of the Cell Adhesion Molecule L1 Interacts with Several Nuclear, Cytoplasmic, and Mitochondrial Proteins Essential for Neuronal Functions.
Marine Sponge-Derived Alkaloid Induces Mitochondrial Dysfunction and Inhibits the PI3K/AKT/mTOR Signaling Pathway against Burkitt's Lymphoma.
The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent Functions.
AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages.
Osteopontin mediates the formation of corpora amylacea-like structures from degenerating neurons in the CA1 region of the rat hippocampus after ischemia.
Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway.
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module.
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells.
The NDUFV2 gene silencing inhibits the proliferation of two drug-resistant cancer cell lines.
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I.
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling.
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Dietary fish oil supplement induces age-specific contractile and proteomic responses in muscles of male rats.
Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice.
A salvage pathway maintains highly functional respiratory complex I.
Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome.
Mitochondrial respiratory chain dysfunction mediated by ROS is a primary point of fluoride-induced damage in Hepa1-6 cells.
CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis.
Subunit composition of respiratory chain complex 1 and its responses to oxygen in mitochondria from human donor livers.
Spatiotemporal expression of osteopontin in the striatum of rats subjected to the mitochondrial toxin 3-nitropropionic acid correlates with microcalcification.
Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex.
Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway.
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.
Increased Expression of Osteopontin in the Degenerating Striatum of Rats Treated with Mitochondrial Toxin 3-Nitropropionic Acid: A Light and Electron Microscopy Study.
NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition.
A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice.
Moschandrea C, Kondylis V, Evangelakos I, Herholz M, Schneider F, Schmidt C, Yang M, Ehret S, Heine M, Jaeckstein MY, Szczepanowska K, Schwarzer R, Baumann L, Bock T, Nikitopoulou E, Brodesser S, Krüger M, Frezza C, Heeren J, Trifunovic A, Pasparakis M
Nature 2024 Jan;625(7994):385-392
Nature 2024 Jan;625(7994):385-392
Acute endoplasmic reticulum stress-induced mitochondria respiratory chain damage: The role of activated calpains.
Chen Q, Li L, Samidurai A, Thompson J, Hu Y, Willard B, Lesnefsky EJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23404
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23404
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat.
Li L, Niemann B, Knapp F, Werner S, Mühlfeld C, Schneider JP, Jurida LM, Molenda N, Schmitz ML, Yin X, Mayr M, Schulz R, Kracht M, Rohrbach S
Basic research in cardiology 2024 Aug;119(4):587-611
Basic research in cardiology 2024 Aug;119(4):587-611
Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia.
Ye L, Gao Y, Mok SWF, Liao W, Wang Y, Chen C, Yang L, Zhang J, Shi L
Journal of nanobiotechnology 2024 Apr 18;22(1):190
Journal of nanobiotechnology 2024 Apr 18;22(1):190
SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.
Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O'Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin S
Basic research in cardiology 2023 May 22;118(1):20
Basic research in cardiology 2023 May 22;118(1):20
The KDET Motif in the Intracellular Domain of the Cell Adhesion Molecule L1 Interacts with Several Nuclear, Cytoplasmic, and Mitochondrial Proteins Essential for Neuronal Functions.
Kleene R, Loers G, Schachner M
International journal of molecular sciences 2023 Jan 4;24(2)
International journal of molecular sciences 2023 Jan 4;24(2)
Marine Sponge-Derived Alkaloid Induces Mitochondrial Dysfunction and Inhibits the PI3K/AKT/mTOR Signaling Pathway against Burkitt's Lymphoma.
Zhao HM, He J, Chang YT, Liu LY, Sun F, Lin HW, Yang F
Journal of natural products 2023 Jan 27;86(1):45-51
Journal of natural products 2023 Jan 27;86(1):45-51
The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent Functions.
Loers G, Kleene R, Bork U, Schachner M
International journal of molecular sciences 2023 Jan 20;24(3)
International journal of molecular sciences 2023 Jan 20;24(3)
AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages.
Xia L, Zhang C, Lv N, Liang Z, Ma T, Cheng H, Xia Y, Shi L
Theranostics 2022;12(6):2928-2947
Theranostics 2022;12(6):2928-2947
Osteopontin mediates the formation of corpora amylacea-like structures from degenerating neurons in the CA1 region of the rat hippocampus after ischemia.
Riew TR, Jin X, Hwang JW, Kim S, Kim HL, Lee MY
Cell and tissue research 2022 Sep;389(3):443-463
Cell and tissue research 2022 Sep;389(3):443-463
Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway.
Li X, Zhou X, Liu X, Li X, Jiang X, Shi B, Wang S
Molecular medicine (Cambridge, Mass.) 2022 Sep 4;28(1):103
Molecular medicine (Cambridge, Mass.) 2022 Sep 4;28(1):103
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Tang M, Xu H, Huang H, Kuang H, Wang C, Li Q, Zhang X, Ge Y, Song M, Zhang X, Wang Z, Ma C, Kang J, Zhang W, Wang Y, Zhang B, Zhang X, Chen Y, Cong M, Melino G, Wang X, Zhou F, Sun Q, Shi H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module.
Jackson TD, Crameri JJ, Muellner-Wong L, Frazier AE, Palmer CS, Formosa LE, Hock DH, Fujihara KM, Stait T, Sharpe AJ, Thorburn DR, Ryan MT, Stroud DA, Stojanovski D
Proceedings of the National Academy of Sciences of the United States of America 2022 Mar 29;119(13):e2115566119
Proceedings of the National Academy of Sciences of the United States of America 2022 Mar 29;119(13):e2115566119
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells.
Ojha R, Tantray I, Rimal S, Mitra S, Cheshier S, Lu B
Developmental cell 2022 Jan 24;57(2):260-276.e9
Developmental cell 2022 Jan 24;57(2):260-276.e9
The NDUFV2 gene silencing inhibits the proliferation of two drug-resistant cancer cell lines.
Liu L, Wang X, Li Y, Ma C, Shi Y, Li X, Chen J
Journal, genetic engineering & biotechnology 2022 Apr 26;20(1):64
Journal, genetic engineering & biotechnology 2022 Apr 26;20(1):64
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I.
Jiang L, Yin X, Chen YH, Chen Y, Jiang W, Zheng H, Huang FQ, Liu B, Zhou W, Qi LW, Li J
Theranostics 2021;11(4):1703-1720
Theranostics 2021;11(4):1703-1720
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling.
Shi Y, Wang Y, Jiang H, Sun X, Xu H, Wei X, Wei Y, Xiao G, Song Z, Zhou F
Cell death & disease 2021 Sep 6;12(9):837
Cell death & disease 2021 Sep 6;12(9):837
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.
Chella Krishnan K, Vergnes L, Acín-Pérez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Péterfy M, Romanoski CE, Reue K, Björkegren JLM, Laakso M, Liesa M, Lusis AJ
Nature metabolism 2021 Nov;3(11):1552-1568
Nature metabolism 2021 Nov;3(11):1552-1568
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Shi M, Huang XY, Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY, Lin SC
Nature cell biology 2021 Mar;23(3):268-277
Nature cell biology 2021 Mar;23(3):268-277
Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice.
Segelcke D, Fischer HK, Hütte M, Dennerlein S, Benseler F, Brose N, Pogatzki-Zahn EM, Schmidt M
Cell reports 2021 Dec 21;37(12):110152
Cell reports 2021 Dec 21;37(12):110152
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
Dietary fish oil supplement induces age-specific contractile and proteomic responses in muscles of male rats.
Russ DW, Dimova K, Morris E, Pacheco M, Garvey SM, Scordilis SP
Lipids in health and disease 2020 Jul 9;19(1):165
Lipids in health and disease 2020 Jul 9;19(1):165
Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice.
Wang HW, Zhu SQ, Liu J, Miao CY, Zhang Y, Zhou BH
Chemosphere 2020 Jan;238:124607
Chemosphere 2020 Jan;238:124607
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice.
Wang HW, Liu J, Wei SS, Zhao WP, Zhu SQ, Zhou BH
Chemosphere 2020 Feb;241:125099
Chemosphere 2020 Feb;241:125099
A salvage pathway maintains highly functional respiratory complex I.
Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, Höhne MN, Hofsetz E, Becker C, Kaspar S, Giese H, Zwicker K, Guerrero-Castillo S, Baumann L, Kauppila J, Rumyantseva A, Müller S, Frese CK, Brandt U, Riemer J, Wittig I, Trifunovic A
Nature communications 2020 Apr 2;11(1):1643
Nature communications 2020 Apr 2;11(1):1643
Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome.
Kang Y, Anderson AJ, Jackson TD, Palmer CS, De Souza DP, Fujihara KM, Stait T, Frazier AE, Clemons NJ, Tull D, Thorburn DR, McConville MJ, Ryan MT, Stroud DA, Stojanovski D
eLife 2019 Nov 4;8
eLife 2019 Nov 4;8
Mitochondrial respiratory chain dysfunction mediated by ROS is a primary point of fluoride-induced damage in Hepa1-6 cells.
Wang HW, Zhang Y, Tan PP, Jia LS, Chen Y, Zhou BH
Environmental pollution (Barking, Essex : 1987) 2019 Dec;255(Pt 3):113359
Environmental pollution (Barking, Essex : 1987) 2019 Dec;255(Pt 3):113359
CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis.
Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P, Trifunovic A
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
Subunit composition of respiratory chain complex 1 and its responses to oxygen in mitochondria from human donor livers.
Khorsandi SE, Taanman JW, Heaton N
BMC research notes 2017 Nov 2;10(1):547
BMC research notes 2017 Nov 2;10(1):547
Spatiotemporal expression of osteopontin in the striatum of rats subjected to the mitochondrial toxin 3-nitropropionic acid correlates with microcalcification.
Riew TR, Kim HL, Jin X, Choi JH, Shin YJ, Kim JS, Lee MY
Scientific reports 2017 Mar 27;7:45173
Scientific reports 2017 Mar 27;7:45173
Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex.
Kang Y, Stroud DA, Baker MJ, De Souza DP, Frazier AE, Liem M, Tull D, Mathivanan S, McConville MJ, Thorburn DR, Ryan MT, Stojanovski D
Molecular cell 2017 Aug 3;67(3):457-470.e5
Molecular cell 2017 Aug 3;67(3):457-470.e5
Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway.
Tang H, Li J, Liu X, Wang G, Luo M, Deng H
Scientific reports 2016 Jun 21;6:28388
Scientific reports 2016 Jun 21;6:28388
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
Pryde KR, Taanman JW, Schapira AH
Cell reports 2016 Dec 6;17(10):2522-2531
Cell reports 2016 Dec 6;17(10):2522-2531
CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A
The EMBO journal 2016 Dec 1;35(23):2566-2583
The EMBO journal 2016 Dec 1;35(23):2566-2583
Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.
Kang Y, Baker MJ, Liem M, Louber J, McKenzie M, Atukorala I, Ang CS, Keerthikumar S, Mathivanan S, Stojanovski D
eLife 2016 Aug 24;5
eLife 2016 Aug 24;5
Increased Expression of Osteopontin in the Degenerating Striatum of Rats Treated with Mitochondrial Toxin 3-Nitropropionic Acid: A Light and Electron Microscopy Study.
Kim HL, Lee MY, Shin YJ, Song DW, Park J, Chang BS, Lee JH
Acta histochemica et cytochemica 2015 Oct 29;48(5):135-43
Acta histochemica et cytochemica 2015 Oct 29;48(5):135-43
NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition.
Chen T, Wu Q, Zhang Y, Zhang D
Brain research 2015 Nov 2;1625:102-10
Brain research 2015 Nov 2;1625:102-10
A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM
The Journal of cell biology 2015 Dec 7;211(5):1057-75
The Journal of cell biology 2015 Dec 7;211(5):1057-75
Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice.
Miwa S, Jow H, Baty K, Johnson A, Czapiewski R, Saretzki G, Treumann A, von Zglinicki T
Nature communications 2014 May 12;5:3837
Nature communications 2014 May 12;5:3837
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 15301-1-AP(NDUFV2 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using NDUFV2 antibody 15301-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate using 15301-1-AP(NDUFV2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate using 15301-1-AP(NDUFV2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue