RASGRF2

RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]

Description

Ras protein specific guanine nucleotide releasing factor 2

Tissue specificity

Tissue enhanced (retina)

Subcell location

Endoplasmic reticulum

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

5:q14.1 (80960363 - 81230162)

Ensembl ID

ENSG00000113319  (ver. 103.38)

Orthologs

Mouse Rasgrf2: ENSMUSG00000021708

UniProt

O14827

neXtProt

NX_O14827

Human splice variants
Mouse splice variants