11-4059-25

antibody from ABEOMICS Inc.
Targeting: IFIT2 cig42, G10P2, GARG-39, IFI-54, IFI54, ISG-54K
Provider product page for 11-4059-25

Antibody data

Product number
11-4059-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-IFIT2 Antibody
Antibody type
Polyclonal
Description
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) is one of four related human (ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, ISG58/IFIT5) and three related mouse proteins (Ifit1, Ifit2, Ifit3) characterized by tetratricopeptide motifs. IFIT2 interacts with eukaryotic initiation factor 3 (eIF3)e and eIF3c to inhibit translation. IFIT2 interacts with some AU-rich RNA regions, which seems to be associated with antiviral activity. IFIT2 possesses antiviral activity against corona virus and West Nile virus by acting on the capped viral mRNA and protects from lethal vesicular stomatitis virus neuropathogenesis. Besides the antiviral activity, IFIT2 expression was associated with induction of apoptosis. IFIT2 may alter proinflammatory cytokine response and therefore be involved in the development of septic shock.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant IFIT2
protein (amino acids 150-370) was u
sed as the immunogen for this antib
ody.
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
IFIT2 protein structure - 11-4059-25 shown in red.