11-4059-25
antibody from ABEOMICS Inc.
Targeting: IFIT2
cig42, G10P2, GARG-39, IFI-54, IFI54, ISG-54K
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 11-4059-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-IFIT2 Antibody
- Antibody type
- Polyclonal
- Description
- Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) is one of four related human (ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, ISG58/IFIT5) and three related mouse proteins (Ifit1, Ifit2, Ifit3) characterized by tetratricopeptide motifs. IFIT2 interacts with eukaryotic initiation factor 3 (eIF3)e and eIF3c to inhibit translation. IFIT2 interacts with some AU-rich RNA regions, which seems to be associated with antiviral activity. IFIT2 possesses antiviral activity against corona virus and West Nile virus by acting on the capped viral mRNA and protects from lethal vesicular stomatitis virus neuropathogenesis. Besides the antiviral activity, IFIT2 expression was associated with induction of apoptosis. IFIT2 may alter proinflammatory cytokine response and therefore be involved in the development of septic shock.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant IFIT2
protein (amino acids 150-370) was u
sed as the immunogen for this antib
ody.- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
No comments: Submit comment
Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of IFIT2. Anti-IFIT2 antibody (11-4059) was used at 4 µg/ml on Hela lysate.