13744-1-AP

antibody from Proteintech Group

Targeting: TRIM22 GPSTAF50, RNF94, STAF50

Provider product page for 13744-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [19]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 13744-1-AP - Provider product page
Provider: Proteintech Group
Product name: TRIM22 antibody
Antibody type: Polyclonal
Description: KD/KO validated TRIM22 antibody (Cat. #13744-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TRIM22 protein structure - 13744-1-AP shown in red.

Submitted references Ubiquitination degradation of GATA4 by CUL4B promotes ovarian cancer metastasis by inducing lysosomal acidification.

Yin X, Gao R, Geng Y, Mu X, Zhang Y, Ma Y, Chen X, Han F, Chen Z, Li F, He J
Genome biology 2026 Feb 9;27(1)

Tripartite Motif-containing 22 Is Involved in TLR3-mediated Inflammatory Pathway in Rheumatoid Fibroblast-like Synoviocytes.

Wada K, Ishibashi HK, Nakamura Y, Saruga T, Imaizumi T, Kurose A, Tachizaki M, Kawaguchi S, Seya K, Oishi K, Sasaki E, Wada K, Ishibashi Y
In vivo (Athens, Greece) 2025 Nov-Dec;39(6):3236-3246

Diagnostic value of TRIM22 in diabetic kidney disease and its mechanism.

Wang Q, Ge Q, Wang J, Wu Y, Qi X
Endocrine 2025 Mar;87(3):959-977

TRIM22 inhibits the metastasis of colorectal cancer through facilitating β-Catenin degradation.

Hu H, Li W, Ma P, Song J, Zhang X, Ruan L, Zhang J, Zheng Y
Experimental cell research 2025 Mar 15;446(2):114473

Tripartite motif 22 (TRIM22) downregulates TLR3-induced CCL5 expression in human renal proximal tubular epithelial cells.

Tachizaki M, Kobori Y, Kawaguchi S, Seya K, Tanaka H, Imaizumi T
Molecular biology reports 2025 Mar 13;52(1):306

Kaposi's sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production.

Zhu Q, McElroy R, Machhar JS, Cassel J, Zheng Z, Mansoori B, Guo H, Guo S, Pangilinan C, Liang J, Shen D, Zhang L, Liu Q, Kossenkov AV, Altieri DC, Lieberman PM, Gao SJ, Feng P, Murphy ME, Song J, Salvino JM, Liang Q, Jung JU, Liang C
Nature microbiology 2025 Jun;10(6):1501-1520

E3 ligase TRIM22 promotes melanoma proliferation by regulating cell cycle progression through K63-linked ubiquitination of p21.

Jin CX, Feng TZ, Ji X, Liu YS, Qin HN, Teng YB, Sampson C, Xia T, Piao HL, Liu JW
Scientific reports 2025 Jul 1;15(1):22311

ADRB2 is regulated by TRIM22 and facilitates lung adenocarcinoma progression via JAK2/STAT3 signaling pathway.

Xu M, Han S, Yang M, Chen J, Liu Y, Zhou Y, Shi J
Scientific reports 2025 Jul 1;15(1):22083

Identification of the immune infiltration and biomarkers in ulcerative colitis based on liquid-liquid phase separation-related genes.

Hong Z, Fang S, Nie H, Zhou J, Hong Y, Liu L, Zhao Q
Scientific reports 2025 Feb 6;15(1):4484

Lycorine hydrochloride Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3 and Erk Pathways.

Liu J, Qiu L, Chen J, Zeng T
Cancers 2025 Feb 20;17(5)

SCAP Interacts with Trim27 to Promote Vascular Neointimal Hyperplasia by Regulating the Stability and Ubiquitination of IκBα.

Yao Y, Wang X, Xuan C, Li D, Huang W, Wei L, Ruan XZ, Li D, Chen Y
Aging and disease 2025 Aug 6;

TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1.

Heo H, Park H, Lee MS, Kim J, Kim J, Jung SY, Kim SK, Lee S, Chang J
Autophagy 2024 May;20(5):1098-1113

The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting proteasomal degradation of NSP8.

Fan L, Zhou Y, Wei X, Feng W, Guo H, Li Y, Gao X, Zhou J, Wen Y, Wu Y, Shen X, Liu L, Xu G, Zhang Z
mBio 2024 Feb 14;15(2):e0232023

Shared biomarkers of multi-tissue origin for primary Sjogren's syndrome and their importance in immune microenvironment alterations.

Cai T, Xu J, Fang Y, Wu Y, Qin Q, Zhang JA
Immunobiology 2023 Sep;228(5):152726

Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen.

Mac Kain A, Maarifi G, Aicher SM, Arhel N, Baidaliuk A, Munier S, Donati F, Vallet T, Tran QD, Hardy A, Chazal M, Porrot F, OhAinle M, Carlson-Stevermer J, Oki J, Holden K, Zimmer G, Simon-Lorière E, Bruel T, Schwartz O, van der Werf S, Jouvenet N, Nisole S, Vignuzzi M, Roesch F
Nature communications 2022 May 4;13(1):2442

Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection.

Charman M, McFarlane S, Wojtus JK, Sloan E, Dewar R, Leeming G, Al-Saadi M, Hunter L, Carroll MW, Stewart JP, Digard P, Hutchinson E, Boutell C
Frontiers in cellular and infection microbiology 2021;11:689707

FOXO3/TRIM22 axis abated the antitumor effect of gemcitabine in non-small cell lung cancer via autophagy induction.

Wang Y, Liang HX, Zhang CM, Zou M, Zou BB, Wei W, Hu W
Translational cancer research 2020 Feb;9(2):937-948

TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K/Akt/mTOR signaling pathway.

Li L, Qi Y, Ma X, Xiong G, Wang L, Bao C
Cell biology international 2018 Sep;42(9):1192-1199

TRIM22 confers poor prognosis and promotes epithelial-mesenchymal transition through regulation of AKT/GSK3β/β-catenin signaling in non-small cell lung cancer.

Liu L, Zhou XM, Yang FF, Miao Y, Yin Y, Hu XJ, Hou G, Wang QY, Kang J
Oncotarget 2017 Sep 22;8(37):62069-62080

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TRIM22 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TRIM22. This antibody recognizes human, mouse antigen. The TRIM22 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 13744-1-AP.pdf

: Show more