MAB939

antibody from R&D Systems

Targeting: ADAM9 CORD9, KIAA0021, MCMP, MDC9, Mltng

Western blot (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Antibody Data

Product number

MAB939

Provider

R&D Systems

Product name

Human ADAM9 Ectodomain Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects human ADAM9 Ectodomain in Western blots. In Western blots, approximately 10% cross-reactivity with the ectodomain of recombinant mouse ADAM9 is observed and no cross-reactivity with the ectodomain of recombinant human ADAM8, 9, 15, or 17 is observed.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

Q13443


Isotype

IgG

Antibody clone number

138537

Vial size

500 ug

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death.

Ueno M, Shiomi T, Mochizuki S, Chijiiwa M, Shimoda M, Kanai Y, Kataoka F, Hirasawa A, Susumu N, Aoki D, Okada Y
Cancer science 2018 Feb;109(2):471-482

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ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT.

Lin CY, Cho CF, Bai ST, Liu JP, Kuo TT, Wang LJ, Lin YS, Lin CC, Lai LC, Lu TP, Hsieh CY, Chu CN, Cheng DC, Sher YP
Scientific reports 2017 Nov 8;7(1):15108

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ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway.

Lin CY, Chen HJ, Huang CC, Lai LC, Lu TP, Tseng GC, Kuo TT, Kuok QY, Hsu JL, Sung SY, Hung MC, Sher YP
Cancer research 2014 Sep 15;74(18):5229-43

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Oxidative stress induces ADAM9 protein expression in human prostate cancer cells.

Sung SY, Kubo H, Shigemura K, Arnold RS, Logani S, Wang R, Konaka H, Nakagawa M, Mousses S, Amin M, Anderson C, Johnstone P, Petros JA, Marshall FF, Zhau HE, Chung LW
Cancer research 2006 Oct 1;66(19):9519-26

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ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin.

Karadag A, Zhou M, Croucher PI
Blood 2006 Apr 15;107(8):3271-8