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- Antibody Data
- Antigen structure
- References [27]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 11727-3-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11727-3-AP, RRID:AB_2122083
- Product name
- IFITM1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IFITM1 antibody (Cat. #11727-3-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Proteomic profiling of ovarian clear cell carcinomas identifies prognostic biomarkers for chemotherapy.
NCOA1/2/3 rearrangements in uterine tumor resembling ovarian sex cord tumor: A clinicopathological and molecular study of 18 cases.
FEZ1 Plays Dual Roles in Early HIV-1 Infection by Independently Regulating Capsid Transport and Host Interferon-Stimulated Gene Expression.
Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication.
IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses.
Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses.
IFITMs of African Green Monkey Can Inhibit Replication of SFTSV but Not MNV In Vitro.
Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells.
Type 1 Interferon Responses Underlie Tumor-Selective Replication of Oncolytic Measles Virus.
Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection.
Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.
The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage.
DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes.
Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection.
Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling.
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
Interferon-Induced Transmembrane Protein-Mediated Inhibition of Host Cell Entry of Ebolaviruses.
Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells.
The antiviral restriction factors IFITM1, 2 and 3 do not inhibit infection of human papillomavirus, cytomegalovirus and adenovirus.
Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
IFITM proteins restrict viral membrane hemifusion.
IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity.
The IFITM proteins inhibit HIV-1 infection.
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.
Yue L, Gong T, Jiang W, Qian L, Gong W, Sun Y, Cai X, Xu H, Liu F, Wang H, Li S, Zhu Y, Zheng Z, Wu Q, Guo T
Proteomics 2024 Mar;24(6):e2300242
Proteomics 2024 Mar;24(6):e2300242
NCOA1/2/3 rearrangements in uterine tumor resembling ovarian sex cord tumor: A clinicopathological and molecular study of 18 cases.
Lu B, Xia Y, Chen J, Tang J, Shao Y, Yu W
Human pathology 2023 May;135:65-75
Human pathology 2023 May;135:65-75
FEZ1 Plays Dual Roles in Early HIV-1 Infection by Independently Regulating Capsid Transport and Host Interferon-Stimulated Gene Expression.
Malikov V, Naghavi MH
Journal of virology 2023 Jun 29;97(6):e0049923
Journal of virology 2023 Jun 29;97(6):e0049923
Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication.
Cai S, Zheng Z, Cheng J, Zhong L, Shao R, Zheng F, Lai Z, Ou J, Xu L, Zhou P, Lu G, Zhang G
Frontiers in immunology 2022;13:827709
Frontiers in immunology 2022;13:827709
IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses.
Clement M, Forbester JL, Marsden M, Sabberwal P, Sommerville MS, Wellington D, Dimonte S, Clare S, Harcourt K, Yin Z, Nobre L, Antrobus R, Jin B, Chen M, Makvandi-Nejad S, Lindborg JA, Strittmatter SM, Weekes MP, Stanton RJ, Dong T, Humphreys IR
Nature communications 2022 Sep 8;13(1):5294
Nature communications 2022 Sep 8;13(1):5294
Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses.
Chen J, Harding SM, Natesan R, Tian L, Benci JL, Li W, Minn AJ, Asangani IA, Greenberg RA
Cell reports 2020 Sep 1;32(9):108080
Cell reports 2020 Sep 1;32(9):108080
IFITMs of African Green Monkey Can Inhibit Replication of SFTSV but Not MNV In Vitro.
Xing H, Ye L, Fan J, Fu T, Li C, Zhang S, Ren L, Bai J
Viral immunology 2020 Dec;33(10):634-641
Viral immunology 2020 Dec;33(10):634-641
Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells.
Zhang L, Wang Z, Kong D, Zhao X, Chen X, Chai W
Bioscience, biotechnology, and biochemistry 2020 Aug;84(8):1603-1613
Bioscience, biotechnology, and biochemistry 2020 Aug;84(8):1603-1613
Type 1 Interferon Responses Underlie Tumor-Selective Replication of Oncolytic Measles Virus.
Aref S, Castleton AZ, Bailey K, Burt R, Dey A, Leongamornlert D, Mitchell RJ, Okasha D, Fielding AK
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Apr 8;28(4):1043-1055
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Apr 8;28(4):1043-1055
Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection.
Wrensch F, Ligat G, Heydmann L, Schuster C, Zeisel MB, Pessaux P, Habersetzer F, King BJ, Tarr AW, Ball JK, Winkler M, Pöhlmann S, Keck ZY, Foung SKH, Baumert TF
Hepatology (Baltimore, Md.) 2019 Nov;70(5):1506-1520
Hepatology (Baltimore, Md.) 2019 Nov;70(5):1506-1520
Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.
Sharma A, McLaughlin RN Jr, Basom RS, Kikawa C, OhAinle M, Yount JS, Emerman M, Overbaugh J
PLoS pathogens 2019 Jul;15(7):e1007925
PLoS pathogens 2019 Jul;15(7):e1007925
The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage.
Yu J, Liu SL
Viruses 2018 Aug 7;10(8)
Viruses 2018 Aug 7;10(8)
DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes.
Lumb JH, Li Q, Popov LM, Ding S, Keith MT, Merrill BD, Greenberg HB, Li JB, Carette JE
Cell reports 2017 Jul 25;20(4):819-831
Cell reports 2017 Jul 25;20(4):819-831
Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA
Nature 2017 Aug 24;548(7668):466-470
Nature 2017 Aug 24;548(7668):466-470
Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection.
Muñoz-Moreno R, Cuesta-Geijo MÁ, Martínez-Romero C, Barrado-Gil L, Galindo I, García-Sastre A, Alonso C
PloS one 2016;11(4):e0154366
PloS one 2016;11(4):e0154366
Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling.
Zeng X, Wang S, Chi X, Chen SL, Huang S, Lin Q, Xie B, Chen JL
Research in veterinary science 2016 Feb;104:40-9
Research in veterinary science 2016 Feb;104:40-9
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
Yu J, Li M, Wilkins J, Ding S, Swartz TH, Esposito AM, Zheng YM, Freed EO, Liang C, Chen BK, Liu SL
Cell reports 2015 Oct 6;13(1):145-156
Cell reports 2015 Oct 6;13(1):145-156
Interferon-Induced Transmembrane Protein-Mediated Inhibition of Host Cell Entry of Ebolaviruses.
Wrensch F, Karsten CB, Gnirß K, Hoffmann M, Lu K, Takada A, Winkler M, Simmons G, Pöhlmann S
The Journal of infectious diseases 2015 Oct 1;212 Suppl 2(Suppl 2):S210-8
The Journal of infectious diseases 2015 Oct 1;212 Suppl 2(Suppl 2):S210-8
Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells.
Grow EJ, Flynn RA, Chavez SL, Bayless NL, Wossidlo M, Wesche DJ, Martin L, Ware CB, Blish CA, Chang HY, Pera RA, Wysocka J
Nature 2015 Jun 11;522(7555):221-5
Nature 2015 Jun 11;522(7555):221-5
The antiviral restriction factors IFITM1, 2 and 3 do not inhibit infection of human papillomavirus, cytomegalovirus and adenovirus.
Warren CJ, Griffin LM, Little AS, Huang IC, Farzan M, Pyeon D
PloS one 2014;9(5):e96579
PloS one 2014;9(5):e96579
Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.
Zhang W, Zhang L, Wu Z, Tien P
Biochemical and biophysical research communications 2014 May 9;447(3):550-5
Biochemical and biophysical research communications 2014 May 9;447(3):550-5
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
Bertram S, Dijkman R, Habjan M, Heurich A, Gierer S, Glowacka I, Welsch K, Winkler M, Schneider H, Hofmann-Winkler H, Thiel V, Pöhlmann S
Journal of virology 2013 Jun;87(11):6150-60
Journal of virology 2013 Jun;87(11):6150-60
IFITM proteins restrict viral membrane hemifusion.
Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL
PLoS pathogens 2013 Jan;9(1):e1003124
PLoS pathogens 2013 Jan;9(1):e1003124
IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.
Mudhasani R, Tran JP, Retterer C, Radoshitzky SR, Kota KP, Altamura LA, Smith JM, Packard BZ, Kuhn JH, Costantino J, Garrison AR, Schmaljohn CS, Huang IC, Farzan M, Bavari S
Journal of virology 2013 Aug;87(15):8451-64
Journal of virology 2013 Aug;87(15):8451-64
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity.
Li J, Liu K, Liu Y, Xu Y, Zhang F, Yang H, Liu J, Pan T, Chen J, Wu M, Zhou X, Yuan Z
Nature immunology 2013 Aug;14(8):793-803
Nature immunology 2013 Aug;14(8):793-803
The IFITM proteins inhibit HIV-1 infection.
Lu J, Pan Q, Rong L, He W, Liu SL, Liang C
Journal of virology 2011 Mar;85(5):2126-37
Journal of virology 2011 Mar;85(5):2126-37
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.
Khodarev N, Ahmad R, Rajabi H, Pitroda S, Kufe T, McClary C, Joshi MD, MacDermed D, Weichselbaum R, Kufe D
Oncogene 2010 Feb 11;29(6):920-9
Oncogene 2010 Feb 11;29(6):920-9
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 11727-3-AP(IFITM1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 11727-3-AP(IFITM1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IFITM1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IFITM1. This antibody recognizes human antigen. The IFITM1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
