Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 60074-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60074-1-Ig, RRID:AB_2233405
- Product name
- IFITM1-Specific antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated IFITM1-Specific antibody (Cat. #60074-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 5B5E2
- Vial size
- 20ul, 150ul
Submitted references Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2.
The Role of IFITM Proteins in Tick-Borne Encephalitis Virus Infection.
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication.
FTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression.
Long Noncoding RNA IFITM4P Regulates Host Antiviral Responses by Acting as a Competing Endogenous RNA.
Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine.
IRF1 regulates the progression of colorectal cancer via interferon‑induced proteins.
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction.
ETV7 limits antiviral gene expression and control of influenza viruses.
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2.
p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication.
The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes.
IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag.
Syncytia formation by SARS-CoV-2-infected cells.
LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2.
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise.
Analysis of IFITM-IFITM Interactions by a Flow Cytometry-Based FRET Assay.
Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins.
IFITM proteins inhibit HIV-1 protein synthesis.
mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3.
A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.
Multi-modal Potentiation of Oncolytic Virotherapy by Vanadium Compounds.
Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition.
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.
Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells.
IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis.
Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome.
Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.
The IFITMs Inhibit Zika Virus Replication.
Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach.
Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection.
IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms.
IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.
IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction.
The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.
IFITM1 is a tight junction protein that inhibits hepatitis C virus entry.
Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection.
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
Shi G, Chiramel AI, Majdoul S, Lai KK, Dempsey T, Kenney A, Zani A, Eddy A, Zhang L, Das S, Beare PA, Andresson T, Kar S, Yount JS, Best SM, Compton AA
bioRxiv : the preprint server for biology 2022 Jan 6;
bioRxiv : the preprint server for biology 2022 Jan 6;
The Role of IFITM Proteins in Tick-Borne Encephalitis Virus Infection.
Chmielewska AM, Gómez-Herranz M, Gach P, Nekulova M, Bagnucka MA, Lipińska AD, Rychłowski M, Hoffmann W, Król E, Vojtesek B, Sloan RD, Bieńkowska-Szewczyk K, Hupp T, Ball K
Journal of virology 2022 Jan 12;96(1):e0113021
Journal of virology 2022 Jan 12;96(1):e0113021
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Abraham HG, Ulintz PJ, Goo L, Yates JA, Little AC, Bao L, Wu Z, Merajver SD
Frontiers in oncology 2021;11:712041
Frontiers in oncology 2021;11:712041
IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication.
Meischel T, Fritzlar S, Villalon-Letelier F, Tessema MB, Brooks AG, Reading PC, Londrigan SL
Journal of virology 2021 Sep 27;95(20):e0083721
Journal of virology 2021 Sep 27;95(20):e0083721
FTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression.
McFadden MJ, Sacco MT, Murphy KA, Park M, Gokhale NS, Somfleth KY, Horner SM
Journal of molecular biology 2021 Sep 16;:167247
Journal of molecular biology 2021 Sep 16;:167247
Long Noncoding RNA IFITM4P Regulates Host Antiviral Responses by Acting as a Competing Endogenous RNA.
Xiao M, Chen Y, Wang S, Liu S, Rai KR, Chen B, Li F, Li Y, Maarouf M, Chen JL
Journal of virology 2021 Oct 13;95(21):e0027721
Journal of virology 2021 Oct 13;95(21):e0027721
Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine.
McFadden MJ, McIntyre ABR, Mourelatos H, Abell NS, Gokhale NS, Ipas H, Xhemalçe B, Mason CE, Horner SM
Cell reports 2021 Mar 2;34(9):108798
Cell reports 2021 Mar 2;34(9):108798
IRF1 regulates the progression of colorectal cancer via interferon‑induced proteins.
Xu X, Wu Y, Yi K, Hu Y, Ding W, Xing C
International journal of molecular medicine 2021 Jun;47(6)
International journal of molecular medicine 2021 Jun;47(6)
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction.
Franz S, Pott F, Zillinger T, Schüler C, Dapa S, Fischer C, Passos V, Stenzel S, Chen F, Döhner K, Hartmann G, Sodeik B, Pessler F, Simmons G, Drexler JF, Goffinet C
Life science alliance 2021 Jul;4(7)
Life science alliance 2021 Jul;4(7)
ETV7 limits antiviral gene expression and control of influenza viruses.
Froggatt HM, Harding AT, Chaparian RR, Heaton NS
Science signaling 2021 Jul 13;14(691)
Science signaling 2021 Jul 13;14(691)
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
Torres-Odio S, Lei Y, Gispert S, Maletzko A, Key J, Menissy SS, Wittig I, Auburger G, West AP
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1890-1900
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1890-1900
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2.
Winstone H, Lista MJ, Reid AC, Bouton C, Pickering S, Galao RP, Kerridge C, Doores KJ, Swanson CM, Neil SJD
Journal of virology 2021 Apr 12;95(9)
Journal of virology 2021 Apr 12;95(9)
p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication.
Wang X, Wu Z, Li Y, Yang Y, Xiao C, Liu X, Xiang X, Wei J, Shao D, Liu K, Deng X, Wu J, Qiu Y, Li B, Ma Z
PLoS pathogens 2020 Oct;16(10):e1009035
PLoS pathogens 2020 Oct;16(10):e1009035
The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes.
Williams GD, Gokhale NS, Snider DL, Horner SM
mSphere 2020 May 13;5(3)
mSphere 2020 May 13;5(3)
IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag.
Ahi YS, Yimer D, Shi G, Majdoul S, Rahman K, Rein A, Compton AA
mBio 2020 Jan 21;11(1)
mBio 2020 Jan 21;11(1)
Syncytia formation by SARS-CoV-2-infected cells.
Buchrieser J, Dufloo J, Hubert M, Monel B, Planas D, Rajah MM, Planchais C, Porrot F, Guivel-Benhassine F, Van der Werf S, Casartelli N, Mouquet H, Bruel T, Schwartz O
The EMBO journal 2020 Dec 1;39(23):e106267
The EMBO journal 2020 Dec 1;39(23):e106267
LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2.
Zhao X, Zheng S, Chen D, Zheng M, Li X, Li G, Lin H, Chang J, Zeng H, Guo JT
Journal of virology 2020 Aug 31;94(18)
Journal of virology 2020 Aug 31;94(18)
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise.
Buchrieser J, Degrelle SA, Couderc T, Nevers Q, Disson O, Manet C, Donahue DA, Porrot F, Hillion KH, Perthame E, Arroyo MV, Souquere S, Ruigrok K, Dupressoir A, Heidmann T, Montagutelli X, Fournier T, Lecuit M, Schwartz O
Science (New York, N.Y.) 2019 Jul 12;365(6449):176-180
Science (New York, N.Y.) 2019 Jul 12;365(6449):176-180
Analysis of IFITM-IFITM Interactions by a Flow Cytometry-Based FRET Assay.
Winkler M, Wrensch F, Bosch P, Knoth M, Schindler M, Gärtner S, Pöhlmann S
International journal of molecular sciences 2019 Aug 8;20(16)
International journal of molecular sciences 2019 Aug 8;20(16)
Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins.
Wang B, Lam TH, Soh MK, Ye Z, Chen J, Ren EC
Frontiers in immunology 2018;9:1193
Frontiers in immunology 2018;9:1193
IFITM proteins inhibit HIV-1 protein synthesis.
Lee WJ, Fu RM, Liang C, Sloan RD
Scientific reports 2018 Sep 28;8(1):14551
Scientific reports 2018 Sep 28;8(1):14551
mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3.
Shi G, Ozog S, Torbett BE, Compton AA
Proceedings of the National Academy of Sciences of the United States of America 2018 Oct 23;115(43):E10069-E10078
Proceedings of the National Academy of Sciences of the United States of America 2018 Oct 23;115(43):E10069-E10078
A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.
Roesch F, OhAinle M, Emerman M
Retrovirology 2018 Mar 20;15(1):26
Retrovirology 2018 Mar 20;15(1):26
Multi-modal Potentiation of Oncolytic Virotherapy by Vanadium Compounds.
Selman M, Rousso C, Bergeron A, Son HH, Krishnan R, El-Sayes NA, Varette O, Chen A, Le Boeuf F, Tzelepis F, Bell JC, Crans DC, Diallo JS
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Jan 3;26(1):56-69
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Jan 3;26(1):56-69
Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition.
Selman M, Ou P, Rousso C, Bergeron A, Krishnan R, Pikor L, Chen A, Keller BA, Ilkow C, Bell JC, Diallo JS
Science translational medicine 2018 Jan 24;10(425)
Science translational medicine 2018 Jan 24;10(425)
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
Petrillo C, Thorne LG, Unali G, Schiroli G, Giordano AMS, Piras F, Cuccovillo I, Petit SJ, Ahsan F, Noursadeghi M, Clare S, Genovese P, Gentner B, Naldini L, Towers GJ, Kajaste-Rudnitski A
Cell stem cell 2018 Dec 6;23(6):820-832.e9
Cell stem cell 2018 Dec 6;23(6):820-832.e9
Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.
Burchill MA, Roby JA, Crochet N, Wind-Rotolo M, Stone AE, Edwards MG, Dran RJ, Kriss MS, Gale M Jr, Rosen HR
PloS one 2017;12(10):e0186213
PloS one 2017;12(10):e0186213
Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells.
Monel B, Compton AA, Bruel T, Amraoui S, Burlaud-Gaillard J, Roy N, Guivel-Benhassine F, Porrot F, Génin P, Meertens L, Sinigaglia L, Jouvenet N, Weil R, Casartelli N, Demangel C, Simon-Lorière E, Moris A, Roingeard P, Amara A, Schwartz O
The EMBO journal 2017 Jun 14;36(12):1653-1668
The EMBO journal 2017 Jun 14;36(12):1653-1668
IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis.
Raposo RAS, de Mulder Rougvie M, Paquin-Proulx D, Brailey PM, Cabido VD, Zdinak PM, Thomas AS, Huang SH, Beckerle GA, Jones RB, Nixon DF
JCI insight 2017 Jan 12;2(1):e85811
JCI insight 2017 Jan 12;2(1):e85811
Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome.
Xu-Yang Z, Pei-Yu B, Chuan-Tao Y, Wei Y, Hong-Wei M, Kang T, Chun-Mei Z, Ying-Feng L, Xin W, Ping-Zhong W, Chang-Xing H, Xue-Fan B, Ying Z, Zhan-Sheng J
Frontiers in immunology 2016;7:535
Frontiers in immunology 2016;7:535
Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.
Foster TL, Wilson H, Iyer SS, Coss K, Doores K, Smith S, Kellam P, Finzi A, Borrow P, Hahn BH, Neil SJD
Cell host & microbe 2016 Oct 12;20(4):429-442
Cell host & microbe 2016 Oct 12;20(4):429-442
The IFITMs Inhibit Zika Virus Replication.
Savidis G, Perreira JM, Portmann JM, Meraner P, Guo Z, Green S, Brass AL
Cell reports 2016 Jun 14;15(11):2323-30
Cell reports 2016 Jun 14;15(11):2323-30
Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach.
Gao F, Liang H, Lu H, Wang J, Xia M, Yuan Z, Yao Y, Wang T, Tan X, Laurence A, Xu H, Yu J, Xiao W, Chen W, Zhou M, Zhang X, Chen Q, Chen X
Clinical epigenetics 2015;7:86
Clinical epigenetics 2015;7:86
Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.
Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, Zhang J, Yu D, Li B, Qian Z
Journal of virology 2015 Mar;89(6):3049-61
Journal of virology 2015 Mar;89(6):3049-61
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P
The Journal of general virology 2015 Jan;96(Pt 1):170-182
The Journal of general virology 2015 Jan;96(Pt 1):170-182
IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection.
Zhu X, He Z, Yuan J, Wen W, Huang X, Hu Y, Lin C, Pan J, Li R, Deng H, Liao S, Zhou R, Wu J, Li J, Li M
Cellular microbiology 2015 Jan;17(1):105-18
Cellular microbiology 2015 Jan;17(1):105-18
IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms.
Wrensch F, Winkler M, Pöhlmann S
Viruses 2014 Sep 26;6(9):3683-98
Viruses 2014 Sep 26;6(9):3683-98
IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.
Tartour K, Appourchaux R, Gaillard J, Nguyen XN, Durand S, Turpin J, Beaumont E, Roch E, Berger G, Mahieux R, Brand D, Roingeard P, Cimarelli A
Retrovirology 2014 Nov 25;11:103
Retrovirology 2014 Nov 25;11:103
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.
Zhao X, Guo F, Liu F, Cuconati A, Chang J, Block TM, Guo JT
Proceedings of the National Academy of Sciences of the United States of America 2014 May 6;111(18):6756-61
Proceedings of the National Academy of Sciences of the United States of America 2014 May 6;111(18):6756-61
IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
Compton AA, Bruel T, Porrot F, Mallet A, Sachse M, Euvrard M, Liang C, Casartelli N, Schwartz O
Cell host & microbe 2014 Dec 10;16(6):736-47
Cell host & microbe 2014 Dec 10;16(6):736-47
Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction.
Lin TY, Chin CR, Everitt AR, Clare S, Perreira JM, Savidis G, Aker AM, John SP, Sarlah D, Carreira EM, Elledge SJ, Kellam P, Brass AL
Cell reports 2013 Nov 27;5(4):895-908
Cell reports 2013 Nov 27;5(4):895-908
The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.
John SP, Chin CR, Perreira JM, Feeley EM, Aker AM, Savidis G, Smith SE, Elia AE, Everitt AR, Vora M, Pertel T, Elledge SJ, Kellam P, Brass AL
Journal of virology 2013 Jul;87(14):7837-52
Journal of virology 2013 Jul;87(14):7837-52
IFITM1 is a tight junction protein that inhibits hepatitis C virus entry.
Wilkins C, Woodward J, Lau DT, Barnes A, Joyce M, McFarlane N, McKeating JA, Tyrrell DL, Gale M Jr
Hepatology (Baltimore, Md.) 2013 Feb;57(2):461-9
Hepatology (Baltimore, Md.) 2013 Feb;57(2):461-9
Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection.
Lau DT, Negash A, Chen J, Crochet N, Sinha M, Zhang Y, Guedj J, Holder S, Saito T, Lemon SM, Luxon BA, Perelson AS, Gale M Jr
Gastroenterology 2013 Feb;144(2):402-413.e12
Gastroenterology 2013 Feb;144(2):402-413.e12
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ
Cell 2009 Dec 24;139(7):1243-54
Cell 2009 Dec 24;139(7):1243-54
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 60074-1-Ig(IFITM1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IFITM1-Specific antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human IFITM1-Specific. This antibody recognizes human antigen. The IFITM1-Specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.