Antibody data
- Antibody Data
- Antigen structure
- References [93]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 12323-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12323-1-AP, RRID:AB_2159695
- Product name
- PAX6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PAX6 antibody (Cat. #12323-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in mice.
Lineage tracing reveals atoh7 positive and negative retinal ganglion cell populations in the zebrafish retina.
ZMIZ1 promotes PAX6 ubiquitination through SMAD3 to drive the malignant progression of acute myeloid leukemia.
Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation in Drosophila.
Neural stem cell-derived exosomal PA2G4 induces ANXA2 degradation to promote mitophagy and alleviate neuronal oxidative stress in cerebral ischemia/reperfusion.
ZIKV envelope protein is a strong blocker of early directional differentiation in the neural lineage.
Silencing of optogenetic and chemogenetic transgenes in human iPSCs involves promoter methylation and methylation-independent mechanisms.
TUT1-catalyzed U6 snRNA 3'-end maturation is essential for RNA splicing and stem cell survival.
Transcriptomic Analysis Uncovers an Unfolded Protein Response in ADNP Syndrome.
The effect of travoprost on primary human limbal epithelial cells and the siRNA-based aniridia limbal epithelial cell model, in vitro.
Increased sensitivity of primary aniridia limbal stromal cells to travoprost, leading to elevated migration and MMP-9 protein levels, in vitro.
High-throughput bioprinting to produce micropatterned neuroepithelial tissues and model TSC2-deficient brain malformations.
Neuroprotective Effects of Qi Jing Wan and Its Active Ingredient Diosgenin Against Cognitive Impairment in Plateau Hypoxia.
Cell type- and factor-specific nonsense-mediated RNA decay.
Optimally Aligned Nerve Scaffolds with Sustained Astaxanthin Release Improve the Inflammatory Microenvironment through Mitophagy Activation.
Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses.
Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions.
Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.
Development of a flexible 3D printed TPU-PVC microfluidic devices for organ-on-a-chip applications.
Low-intensity pulsed ultrasound promotes proliferation and differentiation of neural stem cells to enhance spinal cord injury recovery.
Zika virus capsid protein impairs neural differentiation.
Transcriptome Profiling of Trabecular Meshwork Progenitor Cells.
An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility.
Gut microbiota's role in high-altitude cognitive impairment: the therapeutic potential of Clostridium sp. supplementation.
Clinical characteristics and induced pluripotent stem cells (iPSCs) disease model of Harel-Yoon syndrome caused by compound heterozygous ATAD3A variants.
Garlic Extract Promotes Pancreatic Islet Neogenesis Through α-to-β-Cell Transdifferentiation and Normalizes Glucose Homeostasis in Diabetic Rats.
Directed differentiation of human embryonic stem cells into conjunctival epithelial cells.
Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models.
Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway.
Ginsenoside Rg1 promotes neurite growth of retinal ganglion cells through cAMP/PKA/CREB pathways.
Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi004-A) from a patient with Congenital Nemaline Myopathy.
Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus.
BAF45D-binding to HOX genes was differentially targeted in H9-derived spinal cord neural stem cells.
Transcriptomic profiling of Dip2a in the neural differentiation of mouse embryonic stem cells.
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening.
'Iterative Bleaching Extends Multiplexity' facilitates simultaneous identification of all major retinal cell types.
Early rhombic lip Protogenin(+ve) stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma.
Targeting the glycan epitope type I N-acetyllactosamine enables immunodepletion of human pluripotent stem cells from early differentiated cells.
iASPP regulates neurite development by interacting with Spectrin proteins.
Loss of Dip2b leads to abnormal neural differentiation from mESCs.
End binding-3 inhibitor activates regenerative program in age-related macular degeneration.
Towards the Identification and Characterization of Putative Adult Human Lens Epithelial Stem Cells.
Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells.
Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi002-A) from a patient with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency.
Transient neurogenesis in ischemic cortex from Sox2(+) astrocytes.
Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism.
Overlapping cortical malformations in patients with pathogenic variants in GRIN1 and GRIN2B.
Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways.
NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice.
Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons.
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
miR-124- and let-7-Mediated Reprogram of Human Fibroblasts into SST Interneurons.
Loss of BAF (mSWI/SNF) chromatin-remodeling ATPase Brg1 causes multiple malformations of cortical development in mice.
CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.
Quantitation of Pax-6 protein in ocular impression cytology samples using an electrochemiluminescence immunoassay.
Nicotinamide improves in vitro lens regeneration in a mouse capsular bag model.
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Binge-like Prenatal Ethanol Exposure Causes Impaired Cellular Differentiation in the Embryonic Forebrain and Synaptic and Behavioral Defects in Adult Mice.
Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi001-A) from a healthy female Chinese Han.
Generation of a human induced pluripotent stem cell line (INNDSUi003-A) derived from patient with Becker muscular dystrophy (BMD).
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis.
CRISPR/Cas9-mediated genetic correction reverses spinocerebellar ataxia 3 disease-associated phenotypes in differentiated cerebellar neurons.
In-vitro differentiation of human embryonic stem cells into spinal cord neural stem cells.
Human neuropathology confirms projection neuron and interneuron defects and delayed oligodendrocyte production and maturation in FOXG1 syndrome.
Immunohistochemical evidence for adult human neurogenesis in health and disease.
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Perinatal exposure to nonylphenol promotes proliferation of granule cell precursors in offspring cerebellum: Involvement of the activation of Notch2 signaling.
PAX6 contributes to the activation and proliferation of hepatic stellate cells via activating Hedgehog/GLI1 pathway.
Δ(9)-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons.
Computational and functional analyses of T2D GWAS SNPs for transcription factor binding.
Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.
ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.
Zinc Promotes Patient-Derived Induced Pluripotent Stem Cell Neural Differentiation via ERK-STAT Signaling.
The generation of an induced pluripotent stem cell line (DCGi001-A) from an individual with FOXG1 syndrome carrying the c.460dupG (p.Glu154fs) variation in the FOXG1 gene.
Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2.
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex.
LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration.
Silver Nanoparticles Compromise Female Embryonic Stem Cell Differentiation through Disturbing X Chromosome Inactivation.
The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Rapid Differentiation of Multi-Zone Ocular Cells from Human Induced Pluripotent Stem Cells and Generation of Corneal Epithelial and Endothelial Cells.
Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults.
Hydrocephalus due to multiple ependymal malformations is caused by mutations in the MPDZ gene.
Dynamic Expression Patterns of Progenitor and Neuron Layer Markers in the Developing Human Dentate Gyrus and Fimbria.
miR-342-5p Regulates Neural Stem Cell Proliferation and Differentiation Downstream to Notch Signaling in Mice.
Dynamic Expression Patterns of Progenitor and Pyramidal Neuron Layer Markers in the Developing Human Hippocampus.
Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum.
MicroRNA-mediated non-cell-autonomous regulation of cortical radial glial transformation revealed by a Dicer1 knockout mouse model.
PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation.
Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice.
A robust method to derive functional neural crest cells from human pluripotent stem cells.
Specification and maintenance of oligodendrocyte precursor cells from neural progenitor cells: involvement of microRNA-7a.
Fang Y, Qiu T, Wang P, Bai S, Wang M, Yang C, Wang Y, Zhang P, Wang H, Liu S, Xiao X, Li Q
The EMBO journal 2026 May;45(9):3102-3123
The EMBO journal 2026 May;45(9):3102-3123
Lineage tracing reveals atoh7 positive and negative retinal ganglion cell populations in the zebrafish retina.
Bennett DM, Newland RI, Veldman MB, Miesfeld JB
bioRxiv : the preprint server for biology 2026 Mar 22;
bioRxiv : the preprint server for biology 2026 Mar 22;
ZMIZ1 promotes PAX6 ubiquitination through SMAD3 to drive the malignant progression of acute myeloid leukemia.
Zhou L, Li J, Wang M, Geng Y
Molecular and cellular probes 2026 Jun;87:102070
Molecular and cellular probes 2026 Jun;87:102070
Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation in Drosophila.
Zhang S, Gong S, Yang Y, Gong W, Zhou Q, Yang K, Rui M, Wang S
Cell & bioscience 2026 Jan 28;16(1):23
Cell & bioscience 2026 Jan 28;16(1):23
Neural stem cell-derived exosomal PA2G4 induces ANXA2 degradation to promote mitophagy and alleviate neuronal oxidative stress in cerebral ischemia/reperfusion.
Dai M, Lu T, Li J, Yu H
Apoptosis : an international journal on programmed cell death 2026 Feb 20;31(3)
Apoptosis : an international journal on programmed cell death 2026 Feb 20;31(3)
ZIKV envelope protein is a strong blocker of early directional differentiation in the neural lineage.
Ma ZH, Wang Y, Hassaan NA, Chu XN, Wang PH, Wu C, Xing L
Communications biology 2026 Feb 10;9(1)
Communications biology 2026 Feb 10;9(1)
Silencing of optogenetic and chemogenetic transgenes in human iPSCs involves promoter methylation and methylation-independent mechanisms.
Wang Y, Li Y, Li J, Li M, Qiu X
Epigenetics 2026 Dec;21(1):2606983
Epigenetics 2026 Dec;21(1):2606983
TUT1-catalyzed U6 snRNA 3'-end maturation is essential for RNA splicing and stem cell survival.
Fang Y, Qiu T, Luo H, Wang Y, Yang C, Wang M, Dai Q, Zheng W, Yin R, Xiao X, Li Q
EMBO reports 2026 Apr 9;
EMBO reports 2026 Apr 9;
Transcriptomic Analysis Uncovers an Unfolded Protein Response in ADNP Syndrome.
Bieluszewska A, Wulfridge P, Fang KC, Hong Y, Sawada T, Erwin J, Song H, Ming GL, Sarma K
Molecular and cellular biology 2025;45(4):143-153
Molecular and cellular biology 2025;45(4):143-153
The effect of travoprost on primary human limbal epithelial cells and the siRNA-based aniridia limbal epithelial cell model, in vitro.
Li S, Stachon T, Liu S, Li Z, Hsu SL, Kundu S, Fries FN, Seitz B, Amini M, Suiwal S, Szentmáry N
PloS one 2025;20(8):e0330492
PloS one 2025;20(8):e0330492
Increased sensitivity of primary aniridia limbal stromal cells to travoprost, leading to elevated migration and MMP-9 protein levels, in vitro.
Li S, Stachon T, Liu S, Li Z, Hsu SL, Kundu S, Fries FN, Seitz B, Amini M, Suiwal S, Szentmáry N
PloS one 2025;20(6):e0326967
PloS one 2025;20(6):e0326967
High-throughput bioprinting to produce micropatterned neuroepithelial tissues and model TSC2-deficient brain malformations.
Imani Farahani N, Wong KKL, Allen G, Minhas A, Lin L, Nazir S, Julian LM
Cell reports methods 2025 Oct 20;5(10):101177
Cell reports methods 2025 Oct 20;5(10):101177
Neuroprotective Effects of Qi Jing Wan and Its Active Ingredient Diosgenin Against Cognitive Impairment in Plateau Hypoxia.
Xia T, Yan Z, Shen P, Chang M, Zhang N, Zhang Y, Chen Q, Wang R, Tong L, Zhou W, Ni Z, Gao Y
Pharmaceuticals (Basel, Switzerland) 2025 May 17;18(5)
Pharmaceuticals (Basel, Switzerland) 2025 May 17;18(5)
Cell type- and factor-specific nonsense-mediated RNA decay.
Tan K, Sebat J, Wilkinson MF
Nucleic acids research 2025 May 10;53(9)
Nucleic acids research 2025 May 10;53(9)
Optimally Aligned Nerve Scaffolds with Sustained Astaxanthin Release Improve the Inflammatory Microenvironment through Mitophagy Activation.
Jin X, Liu S, Fang J, Chen F, Xu B, Nan L, Zhao S, Wu Z, Guan Z, Tao K, Liu J
Small (Weinheim an der Bergstrasse, Germany) 2025 Jul;21(26):e2502939
Small (Weinheim an der Bergstrasse, Germany) 2025 Jul;21(26):e2502939
Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses.
Dong H, Pan Z, Jiao P, Ye F, Peng Q, Yu Y, Lai X, Li H, Guan Z, Deng J, Shen T, Tan W, Shi Y, Ding Q, Luo J, Li T, Zhuang H, Xiang K
Nature communications 2025 Jul 7;16(1):6241
Nature communications 2025 Jul 7;16(1):6241
Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions.
Mu Y, Zhang N, Wei D, Yang G, Yao L, Xu X, Li Y, Xue J, Zhang Z, Chen T
Neural regeneration research 2025 Jul 1;20(7):2116-2128
Neural regeneration research 2025 Jul 1;20(7):2116-2128
Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.
Wang J, Zhang J, Li J, Gao Q, Chen J, Jia C, Gu X
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)
Development of a flexible 3D printed TPU-PVC microfluidic devices for organ-on-a-chip applications.
Kado Abdalkader R, Konishi S, Fujita T
Scientific reports 2025 Feb 19;15(1):6125
Scientific reports 2025 Feb 19;15(1):6125
Low-intensity pulsed ultrasound promotes proliferation and differentiation of neural stem cells to enhance spinal cord injury recovery.
Liao YH, Tian MH, Zhou WY, He BQ, Tang C, Tang Q, Ye RP, Zhong DJ
Molecular biology reports 2025 Feb 18;52(1):245
Molecular biology reports 2025 Feb 18;52(1):245
Zika virus capsid protein impairs neural differentiation.
Wang Y, Ma ZH, Hassaan NA, Hao G, Wang PH, Yao M, Wu C, Chen M, Xing L
International journal of biological macromolecules 2025 Aug;319(Pt 2):145479
International journal of biological macromolecules 2025 Aug;319(Pt 2):145479
Transcriptome Profiling of Trabecular Meshwork Progenitor Cells.
Fan X, Kennedy S, Bilir EK, Lane B, Kingston OA, Chen X, Kearns VR, Willoughby CE, Sheridan CM
Stem cell reviews and reports 2025 Aug;21(6):1776-1797
Stem cell reviews and reports 2025 Aug;21(6):1776-1797
An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility.
Tan K, Higgins K, Liu Q, Wilkinson MF
Science advances 2025 Aug 15;11(33):eadt0534
Science advances 2025 Aug 15;11(33):eadt0534
Gut microbiota's role in high-altitude cognitive impairment: the therapeutic potential of Clostridium sp. supplementation.
Zhou W, Zhou Y, Zhang S, Li B, Li Z, Bai Z, Sun D, Huangfu C, Wang N, Xia T, Huang C, Guan L, Yang X, Hu Y, Zhang P, Shen P, Wang R, Ni Z, Gao Y
Science China. Life sciences 2025 Apr;68(4):1132-1148
Science China. Life sciences 2025 Apr;68(4):1132-1148
Clinical characteristics and induced pluripotent stem cells (iPSCs) disease model of Harel-Yoon syndrome caused by compound heterozygous ATAD3A variants.
Jiang Z, Chen H, Zhang X, Jiang X, Tong Z, Ye J, Shi S, Shi X, Li F, Shao W, Shu Q, Yu L
Human cell 2025 Apr 17;38(3):90
Human cell 2025 Apr 17;38(3):90
Garlic Extract Promotes Pancreatic Islet Neogenesis Through α-to-β-Cell Transdifferentiation and Normalizes Glucose Homeostasis in Diabetic Rats.
Al-Adsani AM, Al-Qattan KK, Barhoush SA, Abbood MS, Al-Bustan SA
Molecular nutrition & food research 2024 Oct;68(19):e2400362
Molecular nutrition & food research 2024 Oct;68(19):e2400362
Directed differentiation of human embryonic stem cells into conjunctival epithelial cells.
Hu X, Dong C, Zou D, Wei C, Wang Y, Li Z, Duan H, Li Z
Experimental cell research 2024 Oct 1;442(2):114227
Experimental cell research 2024 Oct 1;442(2):114227
Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models.
He Y, Li R, Yu Y, Huang C, Xu Z, Wang T, Chen M, Huang H, Qi Z
Neurochemistry international 2024 May;175:105700
Neurochemistry international 2024 May;175:105700
Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway.
Liang W, Liu M, Su Y, Wen Y, Wang L, Shan J, Zhao J, Xie K, Wang J
IUBMB life 2024 Mar;76(3):140-160
IUBMB life 2024 Mar;76(3):140-160
Ginsenoside Rg1 promotes neurite growth of retinal ganglion cells through cAMP/PKA/CREB pathways.
Jiang YY, Wei RY, Tang K, Wang Z, Tan NH
Journal of ginseng research 2024 Mar;48(2):163-170
Journal of ginseng research 2024 Mar;48(2):163-170
Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi004-A) from a patient with Congenital Nemaline Myopathy.
Wang Y, Liu W, Yang Y, Wang Y, Tang Y, Zhan Z, Sun X, Jiao Y, Shan D, Zhang R, Wang D, Sun P, Sun X, Yan C, Liu F
Stem cell research 2024 Jun;77:103435
Stem cell research 2024 Jun;77:103435
Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus.
Bertino F, Mukherjee D, Bonora M, Bagowski C, Nardelli J, Metani L, Zanin Venturini DI, Chianese D, Santander N, Salaroglio IC, Hentschel A, Quarta E, Genova T, McKinney AA, Allocco AL, Fiorito V, Petrillo S, Ammirata G, De Giorgio F, Dennis E, Allington G, Maier F, Shoukier M, Gloning KP, Munaron L, Mussano F, Salsano E, Pareyson D, di Rocco M, Altruda F, Panagiotakos G, Kahle KT, Gressens P, Riganti C, Pinton PP, Roos A, Arnold T, Tolosano E, Chiabrando D
Cell reports. Medicine 2024 Jul 16;5(7):101647
Cell reports. Medicine 2024 Jul 16;5(7):101647
BAF45D-binding to HOX genes was differentially targeted in H9-derived spinal cord neural stem cells.
Liu C, Xie Y, Chen X, Liu L, Liu C, Yin Z
Scientific reports 2024 Jan 2;14(1):29
Scientific reports 2024 Jan 2;14(1):29
Transcriptomic profiling of Dip2a in the neural differentiation of mouse embryonic stem cells.
Yao M, Zhang L, Teng X, Lei Y, Xing X, Ren T, Pan Y, Zhang L, Li Z, Lin J, Zheng Y, Xing L, Zhou J, Wu C
Computational and structural biotechnology journal 2024 Dec;23:700-710
Computational and structural biotechnology journal 2024 Dec;23:700-710
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening.
Ramani A, Pasquini G, Gerkau NJ, Jadhav V, Vinchure OS, Altinisik N, Windoffer H, Muller S, Rothenaigner I, Lin S, Mariappan A, Rathinam D, Mirsaidi A, Goureau O, Ricci-Vitiani L, D'Alessandris QG, Wollnik B, Muotri A, Freifeld L, Jurisch-Yaksi N, Pallini R, Rose CR, Busskamp V, Gabriel E, Hadian K, Gopalakrishnan J
Nature communications 2024 Dec 19;15(1):10703
Nature communications 2024 Dec 19;15(1):10703
'Iterative Bleaching Extends Multiplexity' facilitates simultaneous identification of all major retinal cell types.
Kothurkar AA, Patient GS, Noel NCL, Krzywańska AM, Carr BJ, Chu CJ, MacDonald RB
Journal of cell science 2024 Dec 1;137(23)
Journal of cell science 2024 Dec 1;137(23)
Early rhombic lip Protogenin(+ve) stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma.
Visvanathan A, Saulnier O, Chen C, Haldipur P, Orisme W, Delaidelli A, Shin S, Millman J, Bryant A, Abeysundara N, Wu X, Hendrikse LD, Patil V, Bashardanesh Z, Golser J, Livingston BG, Nakashima T, Funakoshi Y, Ong W, Rasnitsyn A, Aldinger KA, Richman CM, Van Ommeren R, Lee JJY, Ly M, Vladoiu MC, Kharas K, Balin P, Erickson AW, Fong V, Zhang J, Suárez RA, Wang H, Huang N, Pallota JG, Douglas T, Haapasalo J, Razavi F, Silvestri E, Sirbu O, Worme S, Kameda-Smith MM, Wu X, Daniels C, MichaelRaj AK, Bhaduri A, Schramek D, Suzuki H, Garzia L, Ahmed N, Kleinman CL, Stein LD, Dirks P, Dunham C, Jabado N, Rich JN, Li W, Sorensen PH, Wechsler-Reya RJ, Weiss WA, Millen KJ, Ellison DW, Dimitrov DS, Taylor MD
Cell 2024 Aug 22;187(17):4733-4750.e26
Cell 2024 Aug 22;187(17):4733-4750.e26
Targeting the glycan epitope type I N-acetyllactosamine enables immunodepletion of human pluripotent stem cells from early differentiated cells.
Rossdam C, Brand S, Beimdiek J, Oberbeck A, Albers MD, Naujok O, Buettner FFR
Glycobiology 2024 Apr 10;34(4)
Glycobiology 2024 Apr 10;34(4)
iASPP regulates neurite development by interacting with Spectrin proteins.
Wang J, Jia C, Gao Q, Zhang J, Gu X
Frontiers in molecular neuroscience 2023;16:1154770
Frontiers in molecular neuroscience 2023;16:1154770
Loss of Dip2b leads to abnormal neural differentiation from mESCs.
Yao M, Pan Y, Ren T, Yang C, Lei Y, Xing X, Zhang L, Cui X, Zheng Y, Xing L, Wu C
Stem cell research & therapy 2023 Sep 13;14(1):248
Stem cell research & therapy 2023 Sep 13;14(1):248
End binding-3 inhibitor activates regenerative program in age-related macular degeneration.
Lee Q, Chan WC, Qu X, Sun Y, Abdelkarim H, Le J, Saqib U, Sun MY, Kruse K, Banerjee A, Hitchinson B, Geyer M, Huang F, Guaiquil V, Mutso AA, Sanders M, Rosenblatt MI, Maienschein-Cline M, Lawrence MS, Gaponenko V, Malik AB, Komarova YA
Cell reports. Medicine 2023 Oct 17;4(10):101223
Cell reports. Medicine 2023 Oct 17;4(10):101223
Towards the Identification and Characterization of Putative Adult Human Lens Epithelial Stem Cells.
Saranya P, Shekhar M, Haripriya A, Muthukkaruppan V, Gowri Priya C
Cells 2023 Nov 29;12(23)
Cells 2023 Nov 29;12(23)
Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells.
Cao L, Wang R, Liu G, Zhang Y, Thorne RF, Zhang XD, Li J, Xia Y, Guo L, Shao F, Gu H, Wu M
EMBO reports 2023 Mar 6;24(3):e55683
EMBO reports 2023 Mar 6;24(3):e55683
Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi002-A) from a patient with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency.
Zhang C, Wang D, Wang Y, Sun P, Zhao D, Zhao X, Zhao Y, Liu F, Xu J, Yan C
Stem cell research 2023 Jun;69:103067
Stem cell research 2023 Jun;69:103067
Transient neurogenesis in ischemic cortex from Sox2(+) astrocytes.
Yang JL, Fan H, Fu FF, Guo BL, Huang Y, Sun L, Wang WT, Xing JL, Hu XT, Ding YQ, Zhang K, Hu YZ, Wang YZ
Neural regeneration research 2023 Jul;18(7):1521-1526
Neural regeneration research 2023 Jul;18(7):1521-1526
Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism.
Shen K, Wu D, Sun B, Zhu Y, Wang H, Zou W, Ma Y, Lu Z
CNS neuroscience & therapeutics 2023 Jan;29(1):256-269
CNS neuroscience & therapeutics 2023 Jan;29(1):256-269
Overlapping cortical malformations in patients with pathogenic variants in GRIN1 and GRIN2B.
Brock S, Laquerriere A, Marguet F, Myers SJ, Hongjie Y, Baralle D, Vanderhasselt T, Stouffs K, Keymolen K, Kim S, Allen J, Shaulsky G, Chelly J, Marcorelle P, Aziza J, Villard L, Sacaze E, de Wit MCY, Wilke M, Mancini GMS, Hehr U, Lim D, Mansour S, Traynelis SF, Beneteau C, Denis-Musquer M, Jansen AC, Fry AE, Bahi-Buisson N
Journal of medical genetics 2023 Feb;60(2):183-192
Journal of medical genetics 2023 Feb;60(2):183-192
Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways.
Zhang W, Zhang M, Xu Z, Yan H, Wang H, Jiang J, Wan J, Tang B, Liu C, Chen C, Meng Q
Nature communications 2023 Aug 24;14(1):5176
Nature communications 2023 Aug 24;14(1):5176
NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice.
Zhang R, Mao W, Niu L, Bao W, Wang Y, Wang Y, Zhu Y, Yang Z, Chen J, Dong J, Cai M, Yuan Z, Song H, Li G, Zhang M, Xiong N, Wei J, Dong Z
eLife 2023 Apr 27;12
eLife 2023 Apr 27;12
Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons.
Sharma SD, Reddy BK, Pal R, Ritakari TE, Cooper JD, Selvaraj BT, Kind PC, Chandran S, Wyllie DJA, Chattarji S
Cell reports 2023 Apr 25;42(4):112344
Cell reports 2023 Apr 25;42(4):112344
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
Wen X, Chen S, Chen X, Qiu H, Wang W, Zhang N, Liu W, Wang T, Ding X, Zhang L
Frontiers in oncology 2022;12:887068
Frontiers in oncology 2022;12:887068
miR-124- and let-7-Mediated Reprogram of Human Fibroblasts into SST Interneurons.
Gu X, Wang J, Jiang X
ACS chemical neuroscience 2022 Sep 21;13(18):2755-2765
ACS chemical neuroscience 2022 Sep 21;13(18):2755-2765
Loss of BAF (mSWI/SNF) chromatin-remodeling ATPase Brg1 causes multiple malformations of cortical development in mice.
Jin Y, Gao X, Lu M, Chen G, Yang X, Ren N, Song Y, Hou C, Li J, Liu Q, Gao J
Human molecular genetics 2022 Oct 10;31(20):3504-3520
Human molecular genetics 2022 Oct 10;31(20):3504-3520
CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.
de Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput C, Pires G, Leonetti C, Abane R, Barris LC, Leray I, Aalto AL, Naceri S, Cordonnier M, Benasolo C, Sanial M, Duchateau A, Vihervaara A, Puustinen MC, Miozzo F, Fergelot P, Lebigot É, Verloes A, Gressens P, Lacombe D, Gobbo J, Garrido C, Westerheide SD, David L, Petitjean M, Taboureau O, Rodrigues-Lima F, Passemard S, Sabéran-Djoneidi D, Nguyen L, Lancaster M, Sistonen L, Mezger V
Nature communications 2022 Nov 16;13(1):7002
Nature communications 2022 Nov 16;13(1):7002
Quantitation of Pax-6 protein in ocular impression cytology samples using an electrochemiluminescence immunoassay.
Zaworski PG, Schwartz R, Burr J, Skutnik D, Mollin A, Kumar B, Ngumah Q, Welch E, Johnson B, Narasimhan J, Weetall M
Analytical biochemistry 2022 Nov 1;656:114876
Analytical biochemistry 2022 Nov 1;656:114876
Nicotinamide improves in vitro lens regeneration in a mouse capsular bag model.
Liu X, Zhou Q, Huang Y, Fan Z, Duan H, Wang M, Li Z, Xie L
Stem cell research & therapy 2022 May 12;13(1):198
Stem cell research & therapy 2022 May 12;13(1):198
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Yang M, Yu H, Yu X, Liang S, Hu Y, Luo Y, Izsvák Z, Sun C, Wang J
Cell stem cell 2022 Mar 3;29(3):400-418.e13
Cell stem cell 2022 Mar 3;29(3):400-418.e13
Binge-like Prenatal Ethanol Exposure Causes Impaired Cellular Differentiation in the Embryonic Forebrain and Synaptic and Behavioral Defects in Adult Mice.
Subbanna S, Basavarajappa BS
Brain sciences 2022 Jun 17;12(6)
Brain sciences 2022 Jun 17;12(6)
Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi001-A) from a healthy female Chinese Han.
Wang D, Zhang R, Wang Y, Sun P, Ji X, Sun X, Xu J, Zhao D, Yan C, Liu F
Stem cell research 2022 Jul;62:102819
Stem cell research 2022 Jul;62:102819
Generation of a human induced pluripotent stem cell line (INNDSUi003-A) derived from patient with Becker muscular dystrophy (BMD).
Ji X, Wang Y, Sun P, Wang D, Sun X, Zhang R, Xu J, Li W, Liu F, Yan C
Stem cell research 2022 Jul;62:102794
Stem cell research 2022 Jul;62:102794
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis.
Dou S, Wang Q, Zhang B, Wei C, Wang H, Liu T, Duan H, Jiang H, Liu M, Qi X, Zhou Q, Xie L, Shi W, Gao H
Cell discovery 2022 Jul 12;8(1):66
Cell discovery 2022 Jul 12;8(1):66
CRISPR/Cas9-mediated genetic correction reverses spinocerebellar ataxia 3 disease-associated phenotypes in differentiated cerebellar neurons.
Song G, Ma Y, Gao X, Zhang X, Zhang F, Tian C, Hou J, Liu Z, Zhao Z, Tian Y
Life medicine 2022 Aug;1(1):27-44
Life medicine 2022 Aug;1(1):27-44
In-vitro differentiation of human embryonic stem cells into spinal cord neural stem cells.
Chen X, Zhao T, Ke N, Qian Y, Wang W, Liu L, Liu C
Neuroreport 2022 Aug 2;33(12):518-525
Neuroreport 2022 Aug 2;33(12):518-525
Human neuropathology confirms projection neuron and interneuron defects and delayed oligodendrocyte production and maturation in FOXG1 syndrome.
Wilpert NM, Marguet F, Maillard C, Guimiot F, Martinovic J, Drunat S, Attié-Bitach T, Razavi F, Tessier A, Capri Y, Laquerrière A, Bahi-Buisson N
European journal of medical genetics 2021 Sep;64(9):104282
European journal of medical genetics 2021 Sep;64(9):104282
Immunohistochemical evidence for adult human neurogenesis in health and disease.
Gault N, Szele FG
WIREs mechanisms of disease 2021 Nov;13(6):e1526
WIREs mechanisms of disease 2021 Nov;13(6):e1526
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Guo X, Cui C, Song J, He Q, Zang N, Hu H, Wang X, Li D, Wang C, Hou X, Li X, Liang K, Yan F, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Perinatal exposure to nonylphenol promotes proliferation of granule cell precursors in offspring cerebellum: Involvement of the activation of Notch2 signaling.
Fang Y, Che X, You M, Xu Y, Wang Y
Neurochemistry international 2020 Nov;140:104843
Neurochemistry international 2020 Nov;140:104843
PAX6 contributes to the activation and proliferation of hepatic stellate cells via activating Hedgehog/GLI1 pathway.
Li C, Tan YH, Sun J, Deng FM, Liu YL
Biochemical and biophysical research communications 2020 May 28;526(2):314-320
Biochemical and biophysical research communications 2020 May 28;526(2):314-320
Δ(9)-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons.
Shum C, Dutan L, Annuario E, Warre-Cornish K, Taylor SE, Taylor RD, Andreae LC, Buckley NJ, Price J, Bhattacharyya S, Srivastava DP
Molecular and cellular neurosciences 2020 Mar;103:103463
Molecular and cellular neurosciences 2020 Mar;103:103463
Computational and functional analyses of T2D GWAS SNPs for transcription factor binding.
Cheng M, Huang X, Zhang M, Huang Q
Biochemical and biophysical research communications 2020 Mar 12;523(3):658-665
Biochemical and biophysical research communications 2020 Mar 12;523(3):658-665
Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.
Díaz NM, Lang RA, Van Gelder RN, Buhr ED
Investigative ophthalmology & visual science 2020 Jun 3;61(6):37
Investigative ophthalmology & visual science 2020 Jun 3;61(6):37
ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.
Sun X, Peng X, Cao Y, Zhou Y, Sun Y
Nature communications 2020 Jun 12;11(1):2984
Nature communications 2020 Jun 12;11(1):2984
Zinc Promotes Patient-Derived Induced Pluripotent Stem Cell Neural Differentiation via ERK-STAT Signaling.
Yang M, Bao D, Shi A, Yuan H, Wang J, He W, Tong X, Qin H
Stem cells and development 2020 Jul 1;29(13):863-875
Stem cells and development 2020 Jul 1;29(13):863-875
The generation of an induced pluripotent stem cell line (DCGi001-A) from an individual with FOXG1 syndrome carrying the c.460dupG (p.Glu154fs) variation in the FOXG1 gene.
Waite AJ, Millar D, Clarke A
Stem cell research 2020 Dec;49:102018
Stem cell research 2020 Dec;49:102018
Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2.
Yang SC, Liu JJ, Wang CK, Lin YT, Tsai SY, Chen WJ, Huang WK, Tu PA, Lin YC, Chang CF, Cheng CL, Lin H, Lai CY, Lin CY, Lee YH, Chiu YC, Hsu CC, Hsu SC, Hsiao M, Schuyler SC, Lu FL, Lu J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10577-10592
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10577-10592
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA
Cell stem cell 2019 Sep 5;25(3):433-446.e7
Cell stem cell 2019 Sep 5;25(3):433-446.e7
Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex.
Arai Y, Cwetsch AW, Coppola E, Cipriani S, Nishihara H, Kanki H, Saillour Y, Freret-Hodara B, Dutriaux A, Okada N, Okano H, Dehay C, Nardelli J, Gressens P, Shimogori T, D'Onofrio G, Pierani A
Cell reports 2019 Oct 15;29(3):645-658.e5
Cell reports 2019 Oct 15;29(3):645-658.e5
LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration.
Mao R, Deng R, Wei Y, Han L, Meng Y, Xie W, Jia Z
Molecular brain 2019 Jul 18;12(1):67
Molecular brain 2019 Jul 18;12(1):67
Silver Nanoparticles Compromise Female Embryonic Stem Cell Differentiation through Disturbing X Chromosome Inactivation.
Zhang J, Chen Y, Gao M, Wang Z, Liu R, Xia T, Liu S
ACS nano 2019 Feb 26;13(2):2050-2061
ACS nano 2019 Feb 26;13(2):2050-2061
The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling.
Wu DM, Zhang T, Liu YB, Deng SH, Han R, Liu T, Li J, Xu Y
Cell death & disease 2019 Apr 25;10(5):349
Cell death & disease 2019 Apr 25;10(5):349
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Rapid Differentiation of Multi-Zone Ocular Cells from Human Induced Pluripotent Stem Cells and Generation of Corneal Epithelial and Endothelial Cells.
Li Z, Duan H, Li W, Hu X, Jia Y, Zhao C, Zhang S, Zhou Q, Shi W
Stem cells and development 2019 Apr 1;28(7):454-463
Stem cells and development 2019 Apr 1;28(7):454-463
Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults.
Cipriani S, Ferrer I, Aronica E, Kovacs GG, Verney C, Nardelli J, Khung S, Delezoide AL, Milenkovic I, Rasika S, Manivet P, Benifla JL, Deriot N, Gressens P, Adle-Biassette H
Cerebral cortex (New York, N.Y. : 1991) 2018 Jul 1;28(7):2458-2478
Cerebral cortex (New York, N.Y. : 1991) 2018 Jul 1;28(7):2458-2478
Hydrocephalus due to multiple ependymal malformations is caused by mutations in the MPDZ gene.
Saugier-Veber P, Marguet F, Lecoquierre F, Adle-Biassette H, Guimiot F, Cipriani S, Patrier S, Brasseur-Daudruy M, Goldenberg A, Layet V, Capri Y, Gérard M, Frébourg T, Laquerrière A
Acta neuropathologica communications 2017 May 1;5(1):36
Acta neuropathologica communications 2017 May 1;5(1):36
Dynamic Expression Patterns of Progenitor and Neuron Layer Markers in the Developing Human Dentate Gyrus and Fimbria.
Cipriani S, Journiac N, Nardelli J, Verney C, Delezoide AL, Guimiot F, Gressens P, Adle-Biassette H
Cerebral cortex (New York, N.Y. : 1991) 2017 Jan 1;27(1):358-372
Cerebral cortex (New York, N.Y. : 1991) 2017 Jan 1;27(1):358-372
miR-342-5p Regulates Neural Stem Cell Proliferation and Differentiation Downstream to Notch Signaling in Mice.
Gao F, Zhang YF, Zhang ZP, Fu LA, Cao XL, Zhang YZ, Guo CJ, Yan XC, Yang QC, Hu YY, Zhao XH, Wang YZ, Wu SX, Ju G, Zheng MH, Han H
Stem cell reports 2017 Apr 11;8(4):1032-1045
Stem cell reports 2017 Apr 11;8(4):1032-1045
Dynamic Expression Patterns of Progenitor and Pyramidal Neuron Layer Markers in the Developing Human Hippocampus.
Cipriani S, Nardelli J, Verney C, Delezoide AL, Guimiot F, Gressens P, Adle-Biassette H
Cerebral cortex (New York, N.Y. : 1991) 2016 Mar;26(3):1255-71
Cerebral cortex (New York, N.Y. : 1991) 2016 Mar;26(3):1255-71
Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum.
Ju J, Liu Q, Zhang Y, Liu Y, Jiang M, Zhang L, He X, Peng C, Zheng T, Lu QR, Li H
Scientific reports 2016 Jul 29;6:30711
Scientific reports 2016 Jul 29;6:30711
MicroRNA-mediated non-cell-autonomous regulation of cortical radial glial transformation revealed by a Dicer1 knockout mouse model.
Zhang C, Ge X, Liu Q, Jiang M, Li MW, Li H
Glia 2015 May;63(5):860-76
Glia 2015 May;63(5):860-76
PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation.
Pan X, Chang X, Leung C, Zhou Z, Cao F, Xie W, Jia Z
Molecular brain 2015 Jun 5;8:36
Molecular brain 2015 Jun 5;8:36
Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice.
Hou C, Ding L, Zhang J, Jin Y, Sun C, Li Z, Sun X, Zhang T, Zhang A, Li H, Gao J
Developmental biology 2014 Nov 1;395(1):167-81
Developmental biology 2014 Nov 1;395(1):167-81
A robust method to derive functional neural crest cells from human pluripotent stem cells.
Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR
American journal of stem cells 2013;2(2):119-31
American journal of stem cells 2013;2(2):119-31
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Zhao X, Wu J, Zheng M, Gao F, Ju G
Molecular biology of the cell 2012 Aug;23(15):2867-78
Molecular biology of the cell 2012 Aug;23(15):2867-78
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- human stomach tissue were subjected to SDS PAGE followed by western blot with 12323-1-AP(PAX6 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 12323-1-AP(PAX6 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The PAX6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PAX6. This antibody recognizes human, mouse, rat antigen. The PAX6 antibody has been validated for the following applications: ELISA, WB, IHC analysis.