NBP2-47915JF549

antibody from Novus Biologicals
Targeting: PAX6 AN, AN1, AN2, D11S812E, WAGR
Provider product page for NBP2-47915JF549
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
NBP2-47915JF549 - Provider product page
Provider
Novus Biologicals
Product name
Mouse Monoclonal Pax6 Antibody
Antibody type
Monoclonal
Description
Protein A or G purified. Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Isotype
IgG
Vial size
0.1 ml
Storage
Store at 4C in the dark.
PAX6 protein structure - NBP2-47915JF549 shown in red.