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- Product number
- 11312-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11312-1-AP, RRID:AB_2127004
- Product name
- IRF3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IRF3 antibody (Cat. #11312-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression.
Prognostic value of cGAS-STING-IRF3 signaling in cholangiocarcinoma patients.
A biomimetic arsenic-based nanozyme enhances dual epigenetic regulation to improve the efficacy of immunotherapy for acute myeloid leukaemia.
Ursodeoxycholic acid against TGEV infection via the JAK-STAT1 signaling pathway.
Porcine reproductive and respiratory syndrome virus N protein-mediated viral replication enhancement via interaction with host caspase-6.
Promotion of hepatocellular carcinoma by small nuclear ribonucleoprotein polypeptide F through upregulation of transmembrane P24 trafficking protein 2 and triggering of the cGAS-STING pathway.
SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways.
TRIM29 knockout pigs exhibit enhanced broad-spectrum disease resilience by amplifying type I interferon antiviral defenses.
Fibroblast growth factor-inducible 14 accelerates pulmonary fibrosis by inducing fibroblast senescence in mice.
The segmented flavivirus ALSV-encoded nucleoprotein VP2 inhibits type I interferon production by targeting RIG-I.
A dual role for ER-Golgi cargo receptor LMAN1 in supporting CSFV replication and restraining RLR signaling.
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway.
ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway.
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance.
Daucosterol ameliorates acute inflammation and fibrosis following myocardial infarction via regulation of the ZBTB16 protein.
A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer.
USP11-PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA-cGAS-STING Pathway After Intracerebral Hemorrhage.
Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
Lactiplantibacillus plantarum GUANKE Enhances Antiviral Defense Against Respiratory Syncytial Virus Through the STING-TBK1-IRF3-IFN Pathway.
NUP98 regulates orthoflavivirus replication through interaction with vRNA and can be targeted for antiviral purposes.
Engineered Hydroxyapatite-Baicalin Nanorods with Sharp Edges for Broad-Spectrum Antiviral Applications.
Trillin attenuates liver ischemia-reperfusion injury by inhibiting autophagy through regulation of the cGAS-STING pathway.
Activation of stimulator of interferon genes (STING) and inhibition of vascular endothelial growth factor receptor (VEGFR) by telatinib induce antitumor activity.
Genome-wide CRISPR screening identifies Annexin A1 as a facilitator of porcine astrovirus entry.
Picornavirus VP2 protein suppresses innate immunity through selective autophagic degradation of IKBKE/IKKε.
Electroacupuncture Attenuates Neuroinflammation and Postoperative Cognitive Dysfunction in Aged Rats by Suppressing the cGAS-STING Pathway.
Investigating the impact and mechanism of Licochalcone B derivative CTG12 on NLRP3 inflammasome.
Cardiomyocyte-Derived USP20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of STING and Mitigating STING-Mediated Inflammation.
Mitochondrial IRF3 drives pulmonary fibrosis by impairing mitophagy and triggering ferroptosis.
Identification of Pinostilbene as a natural STING agonist that triggers FTH1 degradation via K48-ubiquitination to induce ferroptosis in non-small cell lung cancer.
Porcine USP18 inhibits Japanese encephalitis virus replication by regulating the type I interferon signaling pathway.
EBV encoded tegument protein BKRF4 suppresses RLR signaling pathway-mediated interferon production through inhibiting the activation of IRF3 and IRF7.
EMCV Non-Structural Protein 2C Antagonizes cGAS-STING-Mediated Type I Interferon Signaling via Promoting K48-Linked Polyubiquitination and Degradation of STING.
YWHAZ downregulated innate immune responses to RNA viruses by inhibiting the IRF3 signaling pathway.
Enterovirus A71 3AB protein facilitates immune evasion by blocking cGAS recognition of mtDNA.
PIM1 Inhibition Alleviates Aspergillus fumigatus Keratitis by Regulating DDX41-Mediated STING Signaling Pathway.
Hypertension Increases Susceptibility to Lead-Induced Microglial Polarization via ANT1-Mediated Mitochondrial DNA/cGAS/STING Signaling.
Death domain-associated protein (Daxx) impairs colon cancer chemotherapy by inhibiting the cGAS-STING pathway.
Adipose tissue-specific Nrf2 knockdown inhibits the cGAS-STING pathway to attenuate inflammation in obese mice.
Lily polysaccharides alleviate colitis through the microbiota-N8-acetylspermidine-cGAS-STING signaling axis.
Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway.
COPB1-knockdown induced type I interferon signaling activation inhibits Chlamydia psittaci intracellular proliferation.
Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1.
Calycosin inhibits porcine reproductive and respiratory syndrome virus replication and activates RIG-I/IRF3 signaling pathway.
Varicellovirus bovinealpha 1 UL42 targets host IRF3 to inhibit type I interferon β production.
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription.
STING inhibits LINE-1 retrotransposition through sorting ORF1p to lysosomes for degradation.
EcSnx27 facilitates in vitro release of Singapore grouper iridovirus and interacts with its major capsid protein.
Dihydrotanshinone I, a main compound of Salvia miltiorrhiza, alleviates autoimmune and inflammatory diseases by directly targeting IRF3.
STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches.
Biomimetic Nanoregulators Mediated Tyrosine Hydroxylase mRNA and Stimulator of Interferon Genes Antagonist Codelivery for Synergistic Therapy on Parkinson's Disease.
Ipriflavone Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection via RIG-I/IRF3-Mediated Interferon Signaling.
Extrachromosomal circular DNA drives ferroptosis and immunity in trophoblasts via the STING pathway in preeclampsia.
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Salvia miltiorrhiza water extract ameliorated cGAS-STING-mediated acute liver injury by blocking interaction between STING and TBK1.
API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs.
ACOX2 destabilizes the MRE11-RAD50-NBS1 complex and boosts anticancer immunity via the cGAS-STING pathway in clear cell renal cell carcinoma.
Improvement of the stability of ginsenoside Rg5 and its pharmacological efficacy in nonalcoholic steatohepatitis.
ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly.
Deacetylase SIRT1 modulates antiviral innate immunity and autoimmune diseases.
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance.
Mitigating Doxorubicin-Induced Cardiotoxicity and Enhancing Anti-Tumor Efficacy with a Metformin-Integrated Self-Assembled Nanomedicine.
Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release.
AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity.
The effect and mechanism of sanguinarine against PCV2 based on the analysis of network pharmacology and TMT quantitative proteomics.
DSTYK phosphorylates STING at late endosomes to promote STING signaling.
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation.
Chemotherapy boosts anti-angiogenic and anti-PD-1 combination therapy through activation of cCAS-STING pathway in colon cancer.
ASFV pS183L protein negatively regulates RLR-mediated antiviral signalling by blocking MDA5 oligomerisation.
Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis.
Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR-proficient colorectal cancer.
Platelet hitchhiking vascular-disrupting agents for self-amplified tumor-targeting therapy.
The C-terminal nsP1a protein of porcine astrovirus antagonizes interferon beta production by targets MAVS and IRF3 signaling.
Pharmacological inhibition of the cGAS-STING pathway suppresses microglia pyroptosis in sepsis-associated encephalopathy.
African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.
Virus-mimicking nanoparticle potentiates in-situ cancer vaccines by reversing intratumoral DCs via stimulating cytosolic nucleic acid sensors.
A new attenuated and highly immunogenic orthopoxvirus vaccine protects against mpox in mice and macaques.
ALKBH5 deletion ameliorates inflammation by regulating IRF3 signaling in an m(6)A-dependent manner after myocardial infarction.
Inhibiting UGCG prevents PRV infection by decreasing lysosome-associated autophage.
The antiviral activity of myricetin against pseudorabies virus through regulation of the type I interferon signaling pathway.
Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration.
MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling.
Semen Strychni Pulveratum and vomicine alleviate neuroinflammation in amyotrophic lateral sclerosis through cGAS-STING-TBK1 pathway.
Global MicroRNA Profiling of HSV-1 Infected Cornea Identifies miR-329 as a Novel Regulator of Virus Infection.
Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways.
Harnessing nanozyme-immunomodulation for antiviral defense via Fe-nordihydroguaiaretic acid nano-networks.
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
Association of YY1 with STING activation and the inflammatory response during early muscle injury repair.
Human cytomegalovirus UL23 inhibits immune cell migration and blocks antiviral immune cell responses by reducing the expression of chemokines CCL2 and CCL5.
DNAJA2 inhibits Newcastle disease virus replication by targeting its V protein to modulate the MDA5-MAVS pathway.
KAT2A affects the inflammatory progression of lupus nephritis through multilevel regulation of cGAS.
Gallic acid inhibits EMCV infection via targeting the interaction between TBK1 and IRF3 to promote IFN-β expression.
IRF1 amplifies HSV-1-triggered antiviral innate immunity in a feed-forward manner.
Kurarinone Alleviates cGAS-STING-Triggered Inflammatory Diseases by Targeting STING.
Linker histone H1.3 promotes IFN-β production targeting MDA5 signaling to inhibit EMCV infection.
miR-30a enhanced RIG-I-mediated type I interferon antiviral response by targeting USP14.
Targeting STING to disrupt macrophage-mediated adhesion in encapsulating peritoneal sclerosis.
Inhibition of CPT1A activates the cGAS/STING pathway to enhance neutrophil-mediated tumor abrogation in triple-negative breast cancer.
Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors.
Long noncoding RNA USP30-AS1 promotes influenza A virus replication by enhancing PHB1 function.
RNF149 modulates the type I IFN innate antiviral immune responses through degrading IRF3.
RNF144A inhibits autophagy by targeting BECN1 for degradation during L. monocytogenes infection.
Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases.
Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice.
Hsa-miR-7974 Suppresses Epstein-Barr Virus Reactivation by Directly Targeting BZLF1 and BRLF1.
Comprehensive PTM profiling with SCASP-PTM uncovers mechanisms of p62 degradation and ALDOA-mediated tumor progression.
PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway.
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice.
African swine fever virus structural protein p17 inhibits IRF3 activation by recruiting host protein PR65A and inducing apoptotic degradation of STING.
A novel host restriction factor MRPS6 mediates the inhibition of PDCoV infection in HIEC-6 cells.
African swine fever virus MGF505-6R attenuates type I interferon production by targeting STING for degradation.
Schisandrin C enhances type I IFN response activation to reduce tumor growth and sensitize chemotherapy through antitumor immunity.
Quercetin ameliorates ulcerative colitis by restoring the balance of M2/M1 and repairing the intestinal barrier via downregulating cGAS‒STING pathway.
Oleate alters the immune response in non-small cell lung adenocarcinoma through regulation of HMGB1 release.
STING1-accelerated vascular smooth muscle cell senescence-associated vascular calcification in diabetes is ameliorated by oleoylethanolamide via improved mitochondrial DNA oxidative damage.
YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8(+) T cell recruitment.
Zinc-finger CCHC-type containing protein 8 promotes RNA virus replication by suppressing the type-I interferon responses.
Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling.
STING Agonist Delivered by Neutrophil Membrane-Coated Gold Nanoparticles Exerts Synergistic Tumor Inhibition with Radiotherapy.
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis.
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Herpes Simplex Virus Type 2 Blocks IFN-β Production through the Viral UL24 N-Terminal Domain-Mediated Inhibition of IRF-3 Phosphorylation.
A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import.
Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction.
FGF21 attenuates neuroinflammation following subarachnoid hemorrhage through promoting mitophagy and inhibiting the cGAS-STING pathway.
Pseudorabies virus UL38 attenuates the cGAS-STING signaling pathway by recruiting Tollip to promote STING for autophagy degradation.
Exercise activates interferon response of the liver via Gpld1 to enhance antiviral innate immunity.
TRIM25 predominately associates with anti-viral stress granules.
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway.
Manganese suppresses the development of oral leukoplakia by activating the immune response.
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
An IFNγ-dependent immune-endocrine circuit lowers blood glucose to potentiate the innate antiviral immune response.
Identification of key mitochondria-related genes and their relevance to the immune system linking Parkinson's disease and primary Sjögren's syndrome through integrated bioinformatics analyses.
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Fangchinoline induces antiviral response by suppressing STING degradation.
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair.
Encephalomyocarditis Virus Structural Protein VP3 Interacts with MAVS and Promotes its Autophagic Degradation to Interfere with the Type I Interferon Signaling Pathway.
Activation of mitochondrial DNA-mediated cGAS-STING pathway contributes to chronic postsurgical pain by inducing type I interferons and A1 reactive astrocytes in the spinal cord.
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.
Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity.
Troxerutin dampened hypothalamic neuroinflammation via microglial IL-22/IL-22R1/IRF3 activation in dihydrotestosterone-induced polycystic ovary syndrome rats.
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
A suitable and efficient optimization system for the culture of Chlamydia trachomatis in adult inclusion conjunctivitis.
Double-filtration plasmapheresis reduces type I interferon bioavailability and inducing activity in systemic lupus erythematosus.
ZFP36 Facilitates Senecavirus A (SVA) replication by inhibiting the production of type I interferon.
TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis.
Manganese improves CD8(+) T cell recruitment via cGAS-STING in hepatocellular carcinoma.
Ibuprofen modulates macrophage polarization by downregulating poly (ADP-ribose) polymerase 1.
Fish Snx27 promotes viral products by modulating the innate immune response and exosomal machinery.
Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation.
Hunnivirus structural protein VP2 inhibits beta interferon production by targeting the IRF3 essential modulator.
STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.
CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.
Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding.
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
Therapeutic efficacy of a novel self-assembled immunostimulatory siRNA combining apoptosis promotion with RIG-I activation in gliomas.
IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.
Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis.
Japanese encephalitis virus NS4B inhibits interferon beta production by targeting TLR3 and TRIF.
Porcine reproductive and respiratory syndrome virus-mediated lactate facilitates virus replication by targeting MAVS.
Role of OGDH in Atophagy-IRF3-IFN-β pathway during classical swine fever virus infection.
4-Octyl itaconate restricts STING activation by blocking its palmitoylation.
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
The D129L protein of African swine fever virus interferes with the binding of transcriptional coactivator p300 and IRF3 to prevent beta interferon induction.
Naringenin Improves Innate Immune Suppression after PRRSV Infection by Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.
Systemic administration of STING agonist promotes myeloid cells maturation and antitumor immunity through regulating hematopoietic stem and progenitor cell fate.
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes.
Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells.
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion.
Japanese encephalitis virus induces apoptosis by activating the RIG-1 signaling pathway.
MGF360-12L of ASFV-SY18 is an immune-evasion protein that inhibits host type I IFN, NF-κB, and JAK/STAT pathways.
IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.
Prediction and Verification of Curcumin as a Potential Drug for Inhibition of PDCoV Replication in LLC-PK1 Cells.
SARS-CoV-2 NSP13 interacts with host IRF3, blocking antiviral immune responses.
TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Transcriptome Profiling of Vero E6 Cells during Original Parental or Cell-Attenuated Porcine Epidemic Diarrhea Virus Infection.
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Epstein-Barr Virus Envelope Glycoprotein gp110 Inhibits IKKi-Mediated Activation of NF-κB and Promotes the Degradation of β-Catenin.
LncRNA ZNF593-AS alleviates diabetic cardiomyopathy via suppressing IRF3 signaling pathway.
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.
STING deficiency protects against wasp venom-induced acute kidney injury.
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.
STAT3 regulates antiviral immunity by suppressing excessive interferon signaling.
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication.
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING.
Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
African swine fever virus S273R protein antagonizes type I interferon production by interfering with TBK1 and IRF3 interaction.
TBK1-stabilized ZNF268a recruits SETD4 to methylate TBK1 for efficient interferon signaling.
NSUN2-mediated M(5)c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
RNF144A promotes antiviral responses by modulating STING ubiquitination.
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer.
A transformable nanoplatform with multiple therapeutic and immunostimulatory properties for treatment of advanced cancers.
Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy.
A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway.
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response.
A role of STING signaling in obesity-induced lung inflammation.
DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma.
The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1.
Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor.
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.
Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.
Mechanism of selenomethionine inhibiting of PDCoV replication in LLC-PK1 cells based on STAT3/miR-125b-5p-1/HK2 signaling.
DDX56 inhibits PRV replication through regulation of IFN-β signaling pathway by targeting cGAS.
Antiviral Effect of Selenomethionine on Porcine Deltacoronavirus in Pig Kidney Epithelial Cells.
Transcriptome Analyses of Senecavirus A-Infected PK-15 Cells: RIG-I and IRF7 Are the Important Factors in Inducing Type III Interferons.
Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling.
Porcine Sapelovirus 3C(pro) Inhibits the Production of Type I Interferon.
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity.
NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production.
The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1.
RUNX1 inhibits the antiviral immune response against influenza A virus through attenuating type I interferon signaling.
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
I226R Protein of African Swine Fever Virus Is a Suppressor of Innate Antiviral Responses.
HAO1-mediated oxalate metabolism promotes lung pre-metastatic niche formation by inducing neutrophil extracellular traps.
TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway.
Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics.
IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.
Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
Induction of HOXA3 by Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I Interferon Response through Negative Regulation of HO-1 Transcription.
An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP.
Multifaceted Effects and Mechanisms of N-Acetylcysteine on Intestinal Injury in a Porcine Epidemic Diarrhea Virus-Infected Porcine Model.
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection.
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity.
Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection.
SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response.
HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5.
Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation.
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.
Degradation of WTAP blocks antiviral responses by reducing the m(6) A levels of IRF3 and IFNAR1 mRNA.
Inhibition of Antiviral Innate Immunity by Avibirnavirus VP3 via Blocking TBK1-TRAF3 Complex Formation and IRF3 Activation.
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association.
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation.
Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2.
Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl(4)/2-AAF.
African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.
SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5.
Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3.
Nuclear transporter karyopherin subunit alpha 3 levels modulate Porcine circovirus type 2 replication in PK-15 cells.
PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.
Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action.
Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response.
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production.
The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes.
Silica particles disorganize the polarization of pulmonary macrophages in mice.
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study.
Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation.
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.
ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3.
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.
Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China 2018/1.
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Dampened STING-Dependent Interferon Activation in Bats.
Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity.
PTEN-L promotes type I interferon responses and antiviral immunity.
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.
The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection.
Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.
Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.
Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
AIM2 inhibits autophagy and IFN-β production during M. bovis infection.
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response.
Attenuation of cerebral ischemic injury in interferon regulatory factor 3-deficient rat.
Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.
Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.
HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter.
An alternative splicing isoform of MITA antagonizes MITA-mediated induction of type I IFNs.
Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage.
HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.
Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I.
Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities.
Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.
Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3.
Long M, Chen Y, Du R, Yang J, Wang J, Sun Y, Tian X, Wang S, Zhong Y, Liang W, Zhang J, Shang Z
International journal of biological sciences 2026;22(3):1186-1206
International journal of biological sciences 2026;22(3):1186-1206
Prognostic value of cGAS-STING-IRF3 signaling in cholangiocarcinoma patients.
Artbua P, Kentachalee N, Sitthirak S, Sa-Ngiamwibool P, Wichian P, Deenonpoe R
PloS one 2026;21(2):e0342756
PloS one 2026;21(2):e0342756
A biomimetic arsenic-based nanozyme enhances dual epigenetic regulation to improve the efficacy of immunotherapy for acute myeloid leukaemia.
Chang A, Peng H, Chen Y, Zhang H, Xu X, Zhang K, Yang J, Li W, Wang X, Dong X, Ni J
Biomaterials 2026 Oct;333:124215
Biomaterials 2026 Oct;333:124215
Ursodeoxycholic acid against TGEV infection via the JAK-STAT1 signaling pathway.
Sun Z, Liu A, Zhong Y, Song Z, Liao G, Li Y, Song Y, Li Q, Zhang X, Song Z
Veterinary microbiology 2026 May;316:110973
Veterinary microbiology 2026 May;316:110973
Porcine reproductive and respiratory syndrome virus N protein-mediated viral replication enhancement via interaction with host caspase-6.
Zhu D, Fu C, Dong Y, Zhang Q, Li H, Sun Y, Zhang G, Wang H
Journal of virology 2026 May 19;100(5):e0016326
Journal of virology 2026 May 19;100(5):e0016326
Promotion of hepatocellular carcinoma by small nuclear ribonucleoprotein polypeptide F through upregulation of transmembrane P24 trafficking protein 2 and triggering of the cGAS-STING pathway.
Xie X, Pu L, Zeng J, Xu M, Yin X, Liu H, Yang J, Cao J, Song H
International journal of biological macromolecules 2026 Mar;352:151166
International journal of biological macromolecules 2026 Mar;352:151166
SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways.
Yang B, Zhang Y, Wang S, Wu Y, Diao Z, Zhang Q, Lu C, Shen M, Zhang X, Ma S, Yang C, Pei J, Xing H, Liang Y, Wang J
EMBO reports 2026 Mar;27(5):1228-1253
EMBO reports 2026 Mar;27(5):1228-1253
TRIM29 knockout pigs exhibit enhanced broad-spectrum disease resilience by amplifying type I interferon antiviral defenses.
Yang X, Zhong H, Cheng J, Jiang H, Tan J, Wang C, Song C, Cai G, Yang H, Wu Z
PLoS pathogens 2026 Mar;22(3):e1014023
PLoS pathogens 2026 Mar;22(3):e1014023
Fibroblast growth factor-inducible 14 accelerates pulmonary fibrosis by inducing fibroblast senescence in mice.
Guan XX, Zhong WJ, Tang WF, Liu YB, Chen MR, Li JL, Zhang CY, Zhou Y, Guan CX, Wu JN, Ma L, Duan JX
Cellular and molecular life sciences : CMLS 2026 Mar 6;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 6;83(1)
The segmented flavivirus ALSV-encoded nucleoprotein VP2 inhibits type I interferon production by targeting RIG-I.
Pan M, Song Z, Wang M, Zhao M, Fang S, Jin F, Tan Q, Xu W, Che L, Liu N, Sui L, Liu Q, Hou Z, Zhao Y
Microbiology spectrum 2026 Mar 3;14(3):e0248425
Microbiology spectrum 2026 Mar 3;14(3):e0248425
A dual role for ER-Golgi cargo receptor LMAN1 in supporting CSFV replication and restraining RLR signaling.
Han K, Chang Z, Li N, Xiao D, Song M, Wang T, Guo K, Zhang L, Deng W
Journal of virology 2026 Mar 24;100(3):e0006926
Journal of virology 2026 Mar 24;100(3):e0006926
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Yu Q, Guo K, Yang Y, Liu H, Han Y, Yu X, Wang J, Zhao Y, Su X, Zhu K, Zheng S, Wang S, Li W, Huang Y
Journal of nanobiotechnology 2026 Mar 14;24(1)
Journal of nanobiotechnology 2026 Mar 14;24(1)
Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway.
Kuang Y, Shao Y, Chen J, Dai C, Nomura S, Wang F, Chen J, He Y, Xiao X, Zhang C, Feng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158126
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158126
ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway.
Zhang H, Liu X, Ji X, Zhang G, Wang B, Xiong F, Sun D, Wang C
International immunopharmacology 2026 Jun 1;178:116558
International immunopharmacology 2026 Jun 1;178:116558
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
Fan D, Zhong Y, Dong Y, Du M, Huang K, Li X
Journal of advanced research 2026 Jan;79:661-677
Journal of advanced research 2026 Jan;79:661-677
ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance.
Zhang Z, Gao J, Liao X, Zhang Z, Cao X, Gong Y, Chen W, Zhang L, Tsai HI, Wang D, Zhu H
Cell death and differentiation 2026 Jan;33(1):111-125
Cell death and differentiation 2026 Jan;33(1):111-125
Daucosterol ameliorates acute inflammation and fibrosis following myocardial infarction via regulation of the ZBTB16 protein.
Sheng S, Wu P, Wu C, Su H, Guo Z, Wang R, Li J, Duan Y, Zhang S, Ma L
British journal of pharmacology 2026 Jan;183(2):313-332
British journal of pharmacology 2026 Jan;183(2):313-332
A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer.
Cui S, Luo X, Fan G, Jiang J, Wang Y, Yang E, Ma J, Zhang Z, Wang Y, Wang J, Wang D, Wang H, Cheng L, Tian J, Dong Z, Liu Y, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e09933
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e09933
USP11-PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA-cGAS-STING Pathway After Intracerebral Hemorrhage.
He J, Qin Z, Cai Y, Liu H, Wang T, Hu Q, Xu Y, Yang P, Wu X, Qu Y, Guo W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e14283
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e14283
Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.
Li M, Li R, Xu B, Lian Y, Yang C, Li J, Liang J, Ding L, Zhang D, Guo J, Fu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e08753
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e08753
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
Zhang H, Chang A, Xu X, Peng H, Zhang K, Yang J, Li W, Wang X, Wang W, Yin X, Qu C, Dong X, Ni J
Current issues in molecular biology 2026 Jan 27;48(2)
Current issues in molecular biology 2026 Jan 27;48(2)
Lactiplantibacillus plantarum GUANKE Enhances Antiviral Defense Against Respiratory Syncytial Virus Through the STING-TBK1-IRF3-IFN Pathway.
Yue K, Lu S, Ma H, Mi J, Fan Q, Yang T, Huang Y, Song L, Ren Z, Ren L, Xu J
Nutrients 2026 Jan 26;18(3)
Nutrients 2026 Jan 26;18(3)
NUP98 regulates orthoflavivirus replication through interaction with vRNA and can be targeted for antiviral purposes.
Peters MBA, Lindqvist R, Madhu P, Lundmark R, Ivarsson Y, Överby AK
Nucleic acids research 2026 Jan 22;54(3)
Nucleic acids research 2026 Jan 22;54(3)
Engineered Hydroxyapatite-Baicalin Nanorods with Sharp Edges for Broad-Spectrum Antiviral Applications.
Huang Z, Tang M, Tan H, Li Y, Liu Y, Wan H
ACS biomaterials science & engineering 2026 Jan 12;12(1):617-630
ACS biomaterials science & engineering 2026 Jan 12;12(1):617-630
Trillin attenuates liver ischemia-reperfusion injury by inhibiting autophagy through regulation of the cGAS-STING pathway.
Wu T, Yu Q, Wang Y, Tang H, Guo W
International immunopharmacology 2026 Jan 1;168(Pt 2):115790
International immunopharmacology 2026 Jan 1;168(Pt 2):115790
Activation of stimulator of interferon genes (STING) and inhibition of vascular endothelial growth factor receptor (VEGFR) by telatinib induce antitumor activity.
Wang Y, Hou Y, Han J, Zhang Z, Cheng Y, Yang J, Mou L, Fan S, Liu P, Chen K, Dai Y, Zhang C
The Journal of biological chemistry 2026 Feb;302(2):111038
The Journal of biological chemistry 2026 Feb;302(2):111038
Genome-wide CRISPR screening identifies Annexin A1 as a facilitator of porcine astrovirus entry.
Luo Y, Dong Q, Yi S, Zhang W, Du Y, Fang Q, Zhang W, Ouyang K, Chen Y, Yin Y, Wei Z, Qin Y, Huang W
PLoS pathogens 2026 Feb;22(2):e1013943
PLoS pathogens 2026 Feb;22(2):e1013943
Picornavirus VP2 protein suppresses innate immunity through selective autophagic degradation of IKBKE/IKKε.
Li K, Zhang X, Dong D, Zhu B, Wang S, Wen X, Cao W, Ru Y, Tian H, Zhu G, He J, Guo J, Dai J, Zheng H, Yang F, Zhu Z
Autophagy 2026 Feb;22(2):330-350
Autophagy 2026 Feb;22(2):330-350
Electroacupuncture Attenuates Neuroinflammation and Postoperative Cognitive Dysfunction in Aged Rats by Suppressing the cGAS-STING Pathway.
Ma B, Fan S, Deng J, Wei K, Li Y, Yin J, Xie L
Experimental neurobiology 2026 Feb 28;35(1):42-55
Experimental neurobiology 2026 Feb 28;35(1):42-55
Investigating the impact and mechanism of Licochalcone B derivative CTG12 on NLRP3 inflammasome.
Bian S, Fang ZE, Wang L, Wang J, Dong M, Yang N, Wang J, Li L, Xu G
Cell communication and signaling : CCS 2026 Feb 18;24(1)
Cell communication and signaling : CCS 2026 Feb 18;24(1)
Cardiomyocyte-Derived USP20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of STING and Mitigating STING-Mediated Inflammation.
Zhou Y, Ying M, Qi B, Chen Y, Lin W, Zhang C, Lin J, Zhang Y, Yang Z, Huang Z, Wu J, Cai X, Huang W, Huang Z, Cheng Z, Dai S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 15;40(3):e71540
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 15;40(3):e71540
Mitochondrial IRF3 drives pulmonary fibrosis by impairing mitophagy and triggering ferroptosis.
Jiashu Z, Jingbao L, Hua F, Meiqi S, Jing L, Mengyao W, Wei Z
Cellular signalling 2026 Aug;144:112517
Cellular signalling 2026 Aug;144:112517
Identification of Pinostilbene as a natural STING agonist that triggers FTH1 degradation via K48-ubiquitination to induce ferroptosis in non-small cell lung cancer.
Song S, Hua S, Chen G, Yin X, Chen Z, Li C, Zhou D, Zhu B
Redox biology 2026 Apr;91:104099
Redox biology 2026 Apr;91:104099
Porcine USP18 inhibits Japanese encephalitis virus replication by regulating the type I interferon signaling pathway.
Shi H, Li X, Zhou X, Wang H, Qin W, Jin H, Zhao A, Yang S
Veterinary microbiology 2026 Apr;315:110936
Veterinary microbiology 2026 Apr;315:110936
EBV encoded tegument protein BKRF4 suppresses RLR signaling pathway-mediated interferon production through inhibiting the activation of IRF3 and IRF7.
Li M, Gao X, Chen D, Huang W, Chen Y, Chen R, Xu Z, Zhang Y, Wang S, Wang K, Xu C, Chen X, Pan Z, Chi J, Qin Y, Xie X, Zhang J, Peng T, Chen S, Lv X, Li L, Lei Z, Chen Y, Cai M
International journal of medical microbiology : IJMM 2026 Apr 9;322:151712
International journal of medical microbiology : IJMM 2026 Apr 9;322:151712
EMCV Non-Structural Protein 2C Antagonizes cGAS-STING-Mediated Type I Interferon Signaling via Promoting K48-Linked Polyubiquitination and Degradation of STING.
Cheng R, Dong P, Xing W, Jin H, Ma T, Xie J, Wen Y, Su B, Li X, Feng R
Viruses 2026 Apr 5;18(4)
Viruses 2026 Apr 5;18(4)
YWHAZ downregulated innate immune responses to RNA viruses by inhibiting the IRF3 signaling pathway.
Li S, Han J, Wang H, Hou J, Wang L, Hou Z, Zhang Y, Dou X, Xie J, Li H, Li X, Feng R
mSphere 2026 Apr 28;11(4):e0003826
mSphere 2026 Apr 28;11(4):e0003826
Enterovirus A71 3AB protein facilitates immune evasion by blocking cGAS recognition of mtDNA.
Sun P, Yang X, Cui J, Fang G, Wu Y, Chang J, Li X, Xie Y, Gan L, Ma L, Li Z
EMBO reports 2026 Apr 2;
EMBO reports 2026 Apr 2;
PIM1 Inhibition Alleviates Aspergillus fumigatus Keratitis by Regulating DDX41-Mediated STING Signaling Pathway.
Han F, Wang L, Wu J, Ma H, Luo X, Li J
Investigative ophthalmology & visual science 2026 Apr 1;67(4):2
Investigative ophthalmology & visual science 2026 Apr 1;67(4):2
Hypertension Increases Susceptibility to Lead-Induced Microglial Polarization via ANT1-Mediated Mitochondrial DNA/cGAS/STING Signaling.
Zhao Y, Shi F, Hao H, Wang Z, Li J, Liu B, Niu Y, Wang W, Zhang Y
Research (Washington, D.C.) 2025;8:1026
Research (Washington, D.C.) 2025;8:1026
Death domain-associated protein (Daxx) impairs colon cancer chemotherapy by inhibiting the cGAS-STING pathway.
Zhu XI, Huang K, Kao X, Tang Z, Guo W, Wu T, Li Q
Oncology research 2025;33(5):1149-1159
Oncology research 2025;33(5):1149-1159
Adipose tissue-specific Nrf2 knockdown inhibits the cGAS-STING pathway to attenuate inflammation in obese mice.
Zhao L, Tuerxunaili L, Shi G, Wu M, Jiao Y
Frontiers in endocrinology 2025;16:1711793
Frontiers in endocrinology 2025;16:1711793
Lily polysaccharides alleviate colitis through the microbiota-N8-acetylspermidine-cGAS-STING signaling axis.
Wu Y, Wan X, Hou L, Zhang H, Wang J, Wu K, Shao J, Song Z
Frontiers in microbiology 2025;16:1686902
Frontiers in microbiology 2025;16:1686902
Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway.
Liu L, Zhan X, Wang X, Wen J, He C, Chen X, Guo Y, Wang X, Li L, Cheng H, Bai Z, Xiao X
Frontiers in pharmacology 2025;16:1681650
Frontiers in pharmacology 2025;16:1681650
COPB1-knockdown induced type I interferon signaling activation inhibits Chlamydia psittaci intracellular proliferation.
Li N, Yang H, Zhang S, Jiang Y, Lin Y, Chen X, Zhang Y, Yu Y, Ouyang X, Cui Y, Song Y, Jiao J
Frontiers in microbiology 2025;16:1566239
Frontiers in microbiology 2025;16:1566239
Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1.
Wang X, Zhang D, Xiao J, Wang L, Wang J, Cui X, Tan J, Liu Y, Miao S
Theranostics 2025;15(7):3207-3222
Theranostics 2025;15(7):3207-3222
Calycosin inhibits porcine reproductive and respiratory syndrome virus replication and activates RIG-I/IRF3 signaling pathway.
Chang Y, Li Z, Wang M, Pei K, Chang X, Ma J
Frontiers in veterinary science 2025;12:1674259
Frontiers in veterinary science 2025;12:1674259
Varicellovirus bovinealpha 1 UL42 targets host IRF3 to inhibit type I interferon β production.
Yin X, Du Q, Feng D, Song D, Zhang H, Huang Y, Tong D
Veterinary microbiology 2025 Sep;308:110654
Veterinary microbiology 2025 Sep;308:110654
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription.
Cai Y, Zheng J, Zhao L, Wang X, Zhang L, Wang J, Zhang Y, Shi R, Han J, Han W, Chen W
Nature immunology 2025 Sep;26(9):1581-1595
Nature immunology 2025 Sep;26(9):1581-1595
STING inhibits LINE-1 retrotransposition through sorting ORF1p to lysosomes for degradation.
Huang Y, Xu F, Wang L, Mei S, Zhao F, Wang L, Xie Y, Wei L, Hu Y, Gao Z, Xue T, Fang J, Guo F
EMBO reports 2025 Sep;26(18):4607-4630
EMBO reports 2025 Sep;26(18):4607-4630
EcSnx27 facilitates in vitro release of Singapore grouper iridovirus and interacts with its major capsid protein.
Zhao Z, Cai J, Wang S, Liang Y, Qin C, Wu C, Li L, Zang YA, Yu Y, Chen J
Developmental and comparative immunology 2025 Sep;170:105455
Developmental and comparative immunology 2025 Sep;170:105455
Dihydrotanshinone I, a main compound of Salvia miltiorrhiza, alleviates autoimmune and inflammatory diseases by directly targeting IRF3.
Shi W, Wen J, Gao Y, Liu T, Li H, Yang H, Zhao J, Wei Z, Li C, Yao Q, Xiao X, Bai Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157005
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157005
STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches.
Nan Y, Cui D, Guo J, Ma X, Wang J, Guo L, Li T, Yang M, Huang G, Xu A, Ma W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e03660
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e03660
Biomimetic Nanoregulators Mediated Tyrosine Hydroxylase mRNA and Stimulator of Interferon Genes Antagonist Codelivery for Synergistic Therapy on Parkinson's Disease.
Yang L, Li S, Hou C, Zhang Y, Cheng L, Wang Z, He W, Zhang W
ACS nano 2025 Sep 30;19(38):33734-33748
ACS nano 2025 Sep 30;19(38):33734-33748
Ipriflavone Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection via RIG-I/IRF3-Mediated Interferon Signaling.
Chang Y, Li Z, Pei K, Wang M, Chang X
Animals : an open access journal from MDPI 2025 Sep 29;15(19)
Animals : an open access journal from MDPI 2025 Sep 29;15(19)
Extrachromosomal circular DNA drives ferroptosis and immunity in trophoblasts via the STING pathway in preeclampsia.
Wang X, Bian W, Huang M, Li T, Xiong H, Xiang S, Li H, Yang H, Yang H
Biochemical and biophysical research communications 2025 Sep 25;781:152522
Biochemical and biophysical research communications 2025 Sep 25;781:152522
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Li M, Dong W, Cui Y, Li J, Yang C, Zhang D, Fu X
Materials today. Bio 2025 Oct;34:102233
Materials today. Bio 2025 Oct;34:102233
Salvia miltiorrhiza water extract ameliorated cGAS-STING-mediated acute liver injury by blocking interaction between STING and TBK1.
Li C, Xu R, Zhang M, Chen S, Yao Q, Zheng C, Wang X, Wen X, Xiao X, Wang Y, Bai Z
Chinese herbal medicines 2025 Oct;17(4):768-778
Chinese herbal medicines 2025 Oct;17(4):768-778
API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs.
Deng T, Xu J, Qin L, Wang X, Lu C, Huang Y, Liu D, Yan Y, Dong W, Xu P, Zhou J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e05479
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e05479
ACOX2 destabilizes the MRE11-RAD50-NBS1 complex and boosts anticancer immunity via the cGAS-STING pathway in clear cell renal cell carcinoma.
Ye S, Xu W, Chen Z, Zhu C, Ge Q, Lu J, Chang K, Tian X, Anwaier A, Zhu S, Zhou S, Zhang W, Wang Y, Zhao J, Li L, Shi Y, Cai T, Xu D, Zhou X, Ye D, Zhang H
Molecular cancer 2025 Oct 21;24(1):263
Molecular cancer 2025 Oct 21;24(1):263
Improvement of the stability of ginsenoside Rg5 and its pharmacological efficacy in nonalcoholic steatohepatitis.
Ma J, Bai X, Duan Z, Fu R, Zeng W, Li Y, Guan Z, Zhu C
Life sciences 2025 Oct 1;378:123818
Life sciences 2025 Oct 1;378:123818
ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly.
Han XP, Rao M, Chang Y, Zhu JY, Cheng J, Li YT, Qiong W, Ye SC, Zhang Q, Zhang SQ, Chen LL, Hou F, Zhong J, Liu J
Cell research 2025 Nov;35(11):900-912
Cell research 2025 Nov;35(11):900-912
Deacetylase SIRT1 modulates antiviral innate immunity and autoimmune diseases.
Yu SS, Yu H, Geng S, Tang RC, Zhang A, Zhang Y, Sun XY, Zhang J
International journal of biological macromolecules 2025 Nov;329(Pt 2):147873
International journal of biological macromolecules 2025 Nov;329(Pt 2):147873
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
Song H, Li ZW, Xie YT, Tang X, Hu YT, Tan Y, Huang Y, Cheng YL, Pei G, Kuang M
International immunopharmacology 2025 Nov 14;165:115446
International immunopharmacology 2025 Nov 14;165:115446
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance.
Zhu L, Tang Z, Jiang W, Dong Y, Li X, Huang K, Wu T, Xu L, Guo W, Gu Y
Experimental & molecular medicine 2025 May;57(5):1089-1105
Experimental & molecular medicine 2025 May;57(5):1089-1105
Mitigating Doxorubicin-Induced Cardiotoxicity and Enhancing Anti-Tumor Efficacy with a Metformin-Integrated Self-Assembled Nanomedicine.
Huang J, Yang J, Yang Y, Lu X, Xu J, Lu S, Pan H, Zhou W, Li W, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2415227
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2415227
Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release.
Peng Y, Xu J, Wei L, Luo M, Chen S, Wei X, Luo S, Su Z, Wang Z
Molecular medicine (Cambridge, Mass.) 2025 May 7;31(1):176
Molecular medicine (Cambridge, Mass.) 2025 May 7;31(1):176
AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity.
Wang X-T, Zhu X, Lian Z-H, Liu Q, Yan H-H, Qiu Y, Ge X-Y
mBio 2025 May 14;16(5):e0060225
mBio 2025 May 14;16(5):e0060225
The effect and mechanism of sanguinarine against PCV2 based on the analysis of network pharmacology and TMT quantitative proteomics.
Zhang S, Li H, Wang X, Sun P, Zhang H, Yin W, Fan K, Yang H, Zhang Z, Zhong J, Sun Y, Sun N
International journal of biological macromolecules 2025 Mar;296:139767
International journal of biological macromolecules 2025 Mar;296:139767
DSTYK phosphorylates STING at late endosomes to promote STING signaling.
Dong H, Zhang H, Song P, Hu Y, Chen D
EMBO reports 2025 Mar;26(6):1620-1646
EMBO reports 2025 Mar;26(6):1620-1646
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
Xu J, Ren Y, Lu J, Qin F, Yang D, Tang C, Yang Y, Xu J, Liu T, Yi P
Clinical and translational medicine 2025 Mar;15(3):e70249
Clinical and translational medicine 2025 Mar;15(3):e70249
STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation.
Zhang C, Xu P, Wang Y, Chen X, Pan Y, Ma Z, Wang C, Xu H, Zhou G, Zhu F, Xia H
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1535-1551
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1535-1551
Chemotherapy boosts anti-angiogenic and anti-PD-1 combination therapy through activation of cCAS-STING pathway in colon cancer.
Li X, Dong Y, Wang T, Huang K, Guo W, Xu L, Gu Y
International immunopharmacology 2025 Mar 6;149:114212
International immunopharmacology 2025 Mar 6;149:114212
ASFV pS183L protein negatively regulates RLR-mediated antiviral signalling by blocking MDA5 oligomerisation.
Chen H, Yu Q, Gao X, Huang T, Bao C, Guo J, Wang Z, Lv J, Dai J, Babiuk LA, Zou X, Jung YS, Qian Y
Veterinary research 2025 Mar 31;56(1):70
Veterinary research 2025 Mar 31;56(1):70
Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis.
He P, Wen C, Zhang X, Yin H
Journal of medicinal chemistry 2025 Mar 13;68(5):5551-5572
Journal of medicinal chemistry 2025 Mar 13;68(5):5551-5572
Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR-proficient colorectal cancer.
Duan J, Chen T, Li Q, Zhang Y, Lu T, Xue J, Sun Y, Gao L, Zhang Y
Journal for immunotherapy of cancer 2025 Mar 13;13(3)
Journal for immunotherapy of cancer 2025 Mar 13;13(3)
Platelet hitchhiking vascular-disrupting agents for self-amplified tumor-targeting therapy.
Chu H, Xu Y, Shan Y, Sun M, Zhao W, Fang X, Shen N, Tang Z
Journal of nanobiotechnology 2025 Mar 10;23(1):197
Journal of nanobiotechnology 2025 Mar 10;23(1):197
The C-terminal nsP1a protein of porcine astrovirus antagonizes interferon beta production by targets MAVS and IRF3 signaling.
Dong Q, Luo Y, Pan Y, Liu Y, Qin L, Ouyang K, Chen Y, Wei Z, Qin Y, Huang W
Veterinary microbiology 2025 Jun;305:110530
Veterinary microbiology 2025 Jun;305:110530
Pharmacological inhibition of the cGAS-STING pathway suppresses microglia pyroptosis in sepsis-associated encephalopathy.
Zeng QQ, Qi Y, Yu H, Xu Y, Chen JX, Zheng YW, Zhang GF, Zhang QL, Zheng YH, Guo J, Zhao ZH, Wang FS, Jin GL
Journal of neuroinflammation 2025 Jul 9;22(1):176
Journal of neuroinflammation 2025 Jul 9;22(1):176
African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.
Yao M, Li P, Li X, Li W, Qian P
Veterinary research 2025 Jul 5;56(1):137
Veterinary research 2025 Jul 5;56(1):137
Virus-mimicking nanoparticle potentiates in-situ cancer vaccines by reversing intratumoral DCs via stimulating cytosolic nucleic acid sensors.
Chu Y, Wang L, Huang X, Lao C, Luo L, Chen J, Jin F, Zhao L, Hu K, Lv M, Li X, Yang Y, Zhao W, Wang W
Journal of controlled release : official journal of the Controlled Release Society 2025 Jul 10;383:113801
Journal of controlled release : official journal of the Controlled Release Society 2025 Jul 10;383:113801
A new attenuated and highly immunogenic orthopoxvirus vaccine protects against mpox in mice and macaques.
Xu F, Huang Y, Hou Y, Xie Y, Huang B, Zhao F, Gao Z, Chen C, Wang J, Mei S, Hu Y, Wang L, Wei L, Zhang J, Li N, Cong Z, Ma J, Zhu L, Chen T, Lu J, Wei Q, Tan W, Xue J, Guo F
NPJ vaccines 2025 Jul 1;10(1):134
NPJ vaccines 2025 Jul 1;10(1):134
ALKBH5 deletion ameliorates inflammation by regulating IRF3 signaling in an m(6)A-dependent manner after myocardial infarction.
Zhao X, Liang Z, Zhao W, Tao Y, Hao Y, Liu Y, Wang J, Yu J, Ji H, Jiang H, Xu S, Gu J, Yuan Y, Du Z
Biochemical and biophysical research communications 2025 Jan;742:151039
Biochemical and biophysical research communications 2025 Jan;742:151039
Inhibiting UGCG prevents PRV infection by decreasing lysosome-associated autophage.
Fan W, Yao C, Ma Y, Wang H, Liu P, Zhang Z, Chu B, Yang G, Wang M
International journal of biological macromolecules 2025 Jan;285:138303
International journal of biological macromolecules 2025 Jan;285:138303
The antiviral activity of myricetin against pseudorabies virus through regulation of the type I interferon signaling pathway.
Song Y, Zhao X, Chen Y, Yu X, Su T, Wang J, He T, Yin Z, Jia R, Zhao X, Zhou X, Li L, Zou Y, Li M, Zhang D, Zhang Y, Song X
Journal of virology 2025 Jan 31;99(1):e0156724
Journal of virology 2025 Jan 31;99(1):e0156724
Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration.
Gong Z, Chen Z, Li D, Lu X, Wu J, Sun H, Wang X, Liu S, Xia X, Lu F, Jiang J, Sun C, Wang H, Zeng F, Ma X
Journal of nanobiotechnology 2025 Jan 20;23(1):29
Journal of nanobiotechnology 2025 Jan 20;23(1):29
MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling.
Wang H, Cui Z, Sun W, Yi M, Cheng Y, Zhang Y, Du Y, Pan T, Gao R, Feng L, Zeng B, Huang G, Li Y, Wang Y, Zhang CJ, He R, Wang C
Molecular cell 2025 Jan 2;85(1):150-165.e7
Molecular cell 2025 Jan 2;85(1):150-165.e7
Semen Strychni Pulveratum and vomicine alleviate neuroinflammation in amyotrophic lateral sclerosis through cGAS-STING-TBK1 pathway.
Zhan Y, Huang J, Tang X, Du B, Yang B
Journal of ethnopharmacology 2025 Jan 10;336:118741
Journal of ethnopharmacology 2025 Jan 10;336:118741
Global MicroRNA Profiling of HSV-1 Infected Cornea Identifies miR-329 as a Novel Regulator of Virus Infection.
Sharma P, Naqvi RA, Borase H, Kapoor D, Valverde A, Capistrano K, Yadavalli T, Naqvi AR, Shukla D
Investigative ophthalmology & visual science 2025 Feb 3;66(2):61
Investigative ophthalmology & visual science 2025 Feb 3;66(2):61
Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways.
Han F, Wang L, Wu J, Shen L, Li Y, Guo H, Li J
Investigative ophthalmology & visual science 2025 Feb 3;66(2):13
Investigative ophthalmology & visual science 2025 Feb 3;66(2):13
Harnessing nanozyme-immunomodulation for antiviral defense via Fe-nordihydroguaiaretic acid nano-networks.
Wan H, Huang Z, Tang M, Tan H, Deng K, Liu Y, Zhao X, Chen H
Materials today. Bio 2025 Dec;35:102567
Materials today. Bio 2025 Dec;35:102567
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
Shu W, Chen G, Zhang J, Dong K, Zhou T, Cheng S, Zhang T, Zhang J, Li H, Yao Y, Yu S, Liu Y, Zhou X, Shen X, Wang H
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
Association of YY1 with STING activation and the inflammatory response during early muscle injury repair.
Yan X, Hou Z, Li W, Miao S, Zhang Z, Luo J, Tao Y, Li Q, Zhao J, Xu Z
Molecular immunology 2025 Dec;188:142-153
Molecular immunology 2025 Dec;188:142-153
Human cytomegalovirus UL23 inhibits immune cell migration and blocks antiviral immune cell responses by reducing the expression of chemokines CCL2 and CCL5.
Wang H, Zhang C, Li M, Zhao W, Wang J, Ran Y, Yang X, Deng Z, Chen J, Li H
Virulence 2025 Dec;16(1):2500493
Virulence 2025 Dec;16(1):2500493
DNAJA2 inhibits Newcastle disease virus replication by targeting its V protein to modulate the MDA5-MAVS pathway.
Mo J, Zhang F, Jiang Y, Li M, Wu S, Chen R
BMC microbiology 2025 Dec 22;26(1):84
BMC microbiology 2025 Dec 22;26(1):84
KAT2A affects the inflammatory progression of lupus nephritis through multilevel regulation of cGAS.
Tang Y, Zhang Y, Cao Q, Liu J, Zhuang Q
Journal of molecular medicine (Berlin, Germany) 2025 Dec 22;104(1):11
Journal of molecular medicine (Berlin, Germany) 2025 Dec 22;104(1):11
Gallic acid inhibits EMCV infection via targeting the interaction between TBK1 and IRF3 to promote IFN-β expression.
Zhang Y, Wen Y, Xue W, Zhang T, Hou J, Chen X, Feng R, Tan C
Microbiology spectrum 2025 Dec 2;13(12):e0152425
Microbiology spectrum 2025 Dec 2;13(12):e0152425
IRF1 amplifies HSV-1-triggered antiviral innate immunity in a feed-forward manner.
Gao M, Qi Y, Zhang J
Cell insight 2025 Aug;4(4):100255
Cell insight 2025 Aug;4(4):100255
Kurarinone Alleviates cGAS-STING-Triggered Inflammatory Diseases by Targeting STING.
Liu L, Wang Z, Qi Y, Huang A, He C, Zhan X, Xiao X, Bai Z
Phytotherapy research : PTR 2025 Aug;39(8):3450-3465
Phytotherapy research : PTR 2025 Aug;39(8):3450-3465
Linker histone H1.3 promotes IFN-β production targeting MDA5 signaling to inhibit EMCV infection.
Li H, Dou X, Wang N, Lian R, Li S, Xie J, Li X, Yang Y, Wen Y, Feng R
Molecular immunology 2025 Aug;184:137-148
Molecular immunology 2025 Aug;184:137-148
miR-30a enhanced RIG-I-mediated type I interferon antiviral response by targeting USP14.
Zhang J, Wang Y, Sun N, Zou B, Wang Z, Yin H, Xie J, Xia B, Sun N
Microbiology spectrum 2025 Aug 5;13(8):e0018825
Microbiology spectrum 2025 Aug 5;13(8):e0018825
Targeting STING to disrupt macrophage-mediated adhesion in encapsulating peritoneal sclerosis.
Sun J, Sun Y, Guo D, Ye H, Huang Q, Zhou H, Li C, Liao M, You Y, Shang H, Zhou P, Wu D, Witowski J, Hu Z, Peng H
Communications biology 2025 Aug 23;8(1):1266
Communications biology 2025 Aug 23;8(1):1266
Inhibition of CPT1A activates the cGAS/STING pathway to enhance neutrophil-mediated tumor abrogation in triple-negative breast cancer.
Li C, Gao T, Zhao Q, Li Z, Wang Z, Ding S, Zhang M, Qin Y, Xue X, Zhang X, Tian G, Bian XW, Yang Y
Cancer letters 2025 Aug 16;633:217991
Cancer letters 2025 Aug 16;633:217991
Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors.
Shan JL, Zhang KM, Zhong WQ, Yang XY, Li ZL, Huang Y, Du T, Yang D, Tang JH, Chen YH, Zhang HL, Zhu XF, Deng R
Cancer research 2025 Aug 15;85(16):3015-3031
Cancer research 2025 Aug 15;85(16):3015-3031
Long noncoding RNA USP30-AS1 promotes influenza A virus replication by enhancing PHB1 function.
Yu X, Su N, Luo J, Zhang D, Zhang H, Duan M, Shi N
Veterinary microbiology 2025 Apr;303:110444
Veterinary microbiology 2025 Apr;303:110444
RNF149 modulates the type I IFN innate antiviral immune responses through degrading IRF3.
Wu M, Cai J, Qiao G, Li X, Zhou J, Xu F, Ye Y, Wang Y, Xu X, Li J, Tian X, Shao Y, Dong C, Chen Z, Hao C, Yang Y, Zhang J
PLoS pathogens 2025 Apr;21(4):e1013051
PLoS pathogens 2025 Apr;21(4):e1013051
RNF144A inhibits autophagy by targeting BECN1 for degradation during L. monocytogenes infection.
Yang B, Shen M, Lu C, Wang Y, Zhao X, Zhang Q, Qin X, Pei J, Wang H, Wang J
Autophagy 2025 Apr;21(4):789-806
Autophagy 2025 Apr;21(4):789-806
Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases.
Mu W, Xu G, Li L, Wen J, Xiu Y, Zhao J, Liu T, Wei Z, Luo W, Yang H, Wu Z, Zhan X, Xiao X, Bai Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2417686
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2417686
Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice.
Liu DH, Li F, Yang RZ, Wu Z, Meng XY, Li SM, Li WX, Li JK, Wang DD, Wang RY, Li SA, Liu PP, Kang JS
Cell communication and signaling : CCS 2025 Apr 8;23(1):174
Cell communication and signaling : CCS 2025 Apr 8;23(1):174
Hsa-miR-7974 Suppresses Epstein-Barr Virus Reactivation by Directly Targeting BZLF1 and BRLF1.
Li H, Wang H, Wang J, Lu X, Zhang J, Wang M, Yu D, Li Y, Wang S
Viruses 2025 Apr 23;17(5)
Viruses 2025 Apr 23;17(5)
Comprehensive PTM profiling with SCASP-PTM uncovers mechanisms of p62 degradation and ALDOA-mediated tumor progression.
Lin ZP, Gan G, Xu X, Wen C, Ding X, Chen XY, Zhang K, Guo WY, Lin M, Wang YY, Chen X, Xie C, Wang J, Li M, Zhong CQ
Cell reports 2025 Apr 22;44(4):115500
Cell reports 2025 Apr 22;44(4):115500
PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway.
Zhou H, Wang X, Xu T, Gan D, Ma Z, Zhang H, Zhang J, Zeng Q, Xu D
Cardiovascular research 2025 Apr 15;121(1):128-142
Cardiovascular research 2025 Apr 15;121(1):128-142
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.
Yang NS, Zhong WJ, Sha HX, Zhang CY, Jin L, Duan JX, Xiong JB, You ZJ, Zhou Y, Guan CX
International journal of biological sciences 2024;20(5):1927-1946
International journal of biological sciences 2024;20(5):1927-1946
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice.
Sha HX, Liu YB, Qiu YL, Zhong WJ, Yang NS, Zhang CY, Duan JX, Xiong JB, Guan CX, Zhou Y
International journal of biological sciences 2024;20(12):4713-4730
International journal of biological sciences 2024;20(12):4713-4730
African swine fever virus structural protein p17 inhibits IRF3 activation by recruiting host protein PR65A and inducing apoptotic degradation of STING.
Wang S, Xiang Z, Gao P, Zhang Y, Zhou L, Ge X, Guo X, Han J, Yang H
Frontiers in microbiology 2024;15:1428233
Frontiers in microbiology 2024;15:1428233
A novel host restriction factor MRPS6 mediates the inhibition of PDCoV infection in HIEC-6 cells.
Jiang Y, Zhang G, Li L, Chen J, Hao P, Gao Z, Hao J, Xu Z, Wang M, Li C, Jin N
Frontiers in immunology 2024;15:1381026
Frontiers in immunology 2024;15:1381026
African swine fever virus MGF505-6R attenuates type I interferon production by targeting STING for degradation.
Yao M, Cao H, Li W, Hu Z, Rong Z, Yin M, Tian L, Hu D, Li X, Qian P
Frontiers in immunology 2024;15:1380220
Frontiers in immunology 2024;15:1380220
Schisandrin C enhances type I IFN response activation to reduce tumor growth and sensitize chemotherapy through antitumor immunity.
Yang H, Zhan X, Zhao J, Shi W, Liu T, Wei Z, Li H, Hou X, Mu W, Chen Y, Zheng C, Wang Z, Wei S, Xiao X, Bai Z
Frontiers in pharmacology 2024;15:1369563
Frontiers in pharmacology 2024;15:1369563
Quercetin ameliorates ulcerative colitis by restoring the balance of M2/M1 and repairing the intestinal barrier via downregulating cGAS‒STING pathway.
Gao F, Zhu F, Shuai B, Wu M, Wei C, Yuan Y, Gui Y, Tian Y, Fan H, Wu H
Frontiers in pharmacology 2024;15:1351538
Frontiers in pharmacology 2024;15:1351538
Oleate alters the immune response in non-small cell lung adenocarcinoma through regulation of HMGB1 release.
Cole-Skinner B, Andre NM, Blankenheim Z, Root KM, Jafri K, Simmons GE Jr
Frontiers in cell and developmental biology 2024;12:1348707
Frontiers in cell and developmental biology 2024;12:1348707
STING1-accelerated vascular smooth muscle cell senescence-associated vascular calcification in diabetes is ameliorated by oleoylethanolamide via improved mitochondrial DNA oxidative damage.
Chen Z, Li X, Sun X, Xiao S, Chen T, Ren L, Liu N
Free radical biology & medicine 2024 Sep;222:437-455
Free radical biology & medicine 2024 Sep;222:437-455
YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8(+) T cell recruitment.
Yang Z, Wang X, Fu Y, Wu W, Hu Z, Lin Q, Peng W, Pan Y, Wang J, Chen J, Hu D, Zhou Z, Xu L, Zhang Y, Hou J, Chen M
Molecular cancer 2024 Sep 6;23(1):186
Molecular cancer 2024 Sep 6;23(1):186
Zinc-finger CCHC-type containing protein 8 promotes RNA virus replication by suppressing the type-I interferon responses.
Tu S, Zou J, Xiong C, Dai C, Sun H, Luo D, Jin M, Chen H, Zhou H
Journal of virology 2024 Sep 17;98(9):e0079624
Journal of virology 2024 Sep 17;98(9):e0079624
Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling.
Shi Y, Wu Z, Liu S, Zuo D, Niu Y, Qiu Y, Qiao L, He W, Qiu J, Yuan Y, Wang G, Li B
Nature communications 2024 Sep 10;15(1):7930
Nature communications 2024 Sep 10;15(1):7930
STING Agonist Delivered by Neutrophil Membrane-Coated Gold Nanoparticles Exerts Synergistic Tumor Inhibition with Radiotherapy.
Lu D, Li W, Tan J, Li Y, Mao W, Zheng Y, Yang M, Wang J, Wang W, Wang S, Gao J, Liu Y
ACS applied materials & interfaces 2024 Oct 9;16(40):53474-53488
ACS applied materials & interfaces 2024 Oct 9;16(40):53474-53488
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis.
Wang L, Zhang X, Huang X, Sha X, Li X, Zheng J, Li S, Wei Z, Wu F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70127
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70127
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Herpes Simplex Virus Type 2 Blocks IFN-β Production through the Viral UL24 N-Terminal Domain-Mediated Inhibition of IRF-3 Phosphorylation.
Zhang B, Li Y, Yang P, He S, Li W, Li M, Hu Q, Zhang M
Viruses 2024 Oct 11;16(10)
Viruses 2024 Oct 11;16(10)
A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import.
Boulay A, Quevarec E, Malet I, Nicastro G, Chamontin C, Perrin S, Henriquet C, Pugnière M, Courgnaud V, Blaise M, Marcelin AG, Taylor IA, Chaloin L, Arhel NJ
EMBO molecular medicine 2024 Nov;16(11):2918-2945
EMBO molecular medicine 2024 Nov;16(11):2918-2945
Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction.
Xiu Y, Wang S, Zhang P, Li C, Wu Z, Wen J, Xu Y, Lv G, Zhao X, Dong X, Chen Y, Li J, Wang Y, Zou L, Xiao X, Bai Z
Chinese journal of natural medicines 2024 May;22(5):402-415
Chinese journal of natural medicines 2024 May;22(5):402-415
FGF21 attenuates neuroinflammation following subarachnoid hemorrhage through promoting mitophagy and inhibiting the cGAS-STING pathway.
Ma Y, Liu Z, Deng L, Du J, Fan Z, Ma T, Xiong J, Xiuyun X, Gu N, Di Z, Zhang Y
Journal of translational medicine 2024 May 8;22(1):436
Journal of translational medicine 2024 May 8;22(1):436
Pseudorabies virus UL38 attenuates the cGAS-STING signaling pathway by recruiting Tollip to promote STING for autophagy degradation.
Yan Z, Xie J, Hou Z, Zhang Y, Yue J, Zhang X, Chen L, Yang Y, Li X, Li H, Feng R
Virology journal 2024 May 8;21(1):107
Virology journal 2024 May 8;21(1):107
Exercise activates interferon response of the liver via Gpld1 to enhance antiviral innate immunity.
Ren T, He J, Zhang T, Niu A, Yuan Y, Zuo Y, Miao Y, Zhang H, Zang L, Qiao C, Cao X, Yang X, Zheng Z, Xu Y, Wu D, Zheng H
Science advances 2024 May 31;10(22):eadk5011
Science advances 2024 May 31;10(22):eadk5011
TRIM25 predominately associates with anti-viral stress granules.
Shang Z, Zhang S, Wang J, Zhou L, Zhang X, Billadeau DD, Yang P, Zhang L, Zhou F, Bai P, Jia D
Nature communications 2024 May 15;15(1):4127
Nature communications 2024 May 15;15(1):4127
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
Yang M, Gao L, Gao Y, Hao Z, Zhou X, Su G, Bai C, Wei Z, Liu X, Yang L, Li G
International journal of molecular sciences 2024 May 12;25(10)
International journal of molecular sciences 2024 May 12;25(10)
Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway.
Zuo Z, He S, Qiu Y, Guo R, He Y, Jiao C, Xia Y, Liu W, Luan C, Guo W
International immunopharmacology 2024 May 10;132:111971
International immunopharmacology 2024 May 10;132:111971
Manganese suppresses the development of oral leukoplakia by activating the immune response.
Shi Y, Su C, Ding T, Zhao H, Wang Y, Ren Y, Wu L, Zhang Q, Liang J, Sun S, Wang J, Li J, Zeng X
Oral diseases 2024 Mar;30(2):462-476
Oral diseases 2024 Mar;30(2):462-476
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.
Wu Z, Zhao X, Li R, Wen X, Xiu Y, Long M, Li J, Huang X, Wen J, Dong X, Xu Y, Bai Z, Zhan X, Xiao X
Chinese medicine 2024 Mar 18;19(1):48
Chinese medicine 2024 Mar 18;19(1):48
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Li XQ, Cai MP, Wang MY, Shi BW, Yang GY, Wang J, Chu BB, Ming SL
Virologica Sinica 2024 Jun;39(3):403-413
Virologica Sinica 2024 Jun;39(3):403-413
An IFNγ-dependent immune-endocrine circuit lowers blood glucose to potentiate the innate antiviral immune response.
Šestan M, Mikašinović S, Benić A, Wueest S, Dimitropoulos C, Mladenić K, Krapić M, Hiršl L, Glantzspiegel Y, Rasteiro A, Aliseychik M, Cekinović Grbeša Đ, Turk Wensveen T, Babić M, Gat-Viks I, Veiga-Fernandes H, Konrad D, Wensveen FM, Polić B
Nature immunology 2024 Jun;25(6):981-993
Nature immunology 2024 Jun;25(6):981-993
Identification of key mitochondria-related genes and their relevance to the immune system linking Parkinson's disease and primary Sjögren's syndrome through integrated bioinformatics analyses.
Zong Y, Yang Y, Zhao J, Li L, Luo D, Hu J, Gao Y, Xie X, Shen L, Chen S, Ning L, Jiang L
Computers in biology and medicine 2024 Jun;175:108511
Computers in biology and medicine 2024 Jun;175:108511
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Wang Y, Xu G, Wen J, Zhao X, Zhao H, Lv G, Xu Y, Xiu Y, Li J, Chen S, Yao Q, Chen Y, Ma L, Xiao X, Cao J, Bai Z
Immunology 2024 Jun;172(2):295-312
Immunology 2024 Jun;172(2):295-312
Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Wu B, Li D, Bai H, Mo R, Li H, Xie J, Zhang X, Yang Y, Li H, Idris A, Li X, Feng R
Molecular immunology 2024 Jun;170:131-143
Molecular immunology 2024 Jun;170:131-143
Fangchinoline induces antiviral response by suppressing STING degradation.
Wang J, Xie F, Jia X, Wang X, Kong L, Li Y, Liang X, Zhang M, He Y, Feng W, Luo T, Wang Y, Xu A
Journal of pharmaceutical analysis 2024 Jun;14(6):100972
Journal of pharmaceutical analysis 2024 Jun;14(6):100972
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
Shi W, Xu G, Gao Y, Yang H, Liu T, Zhao J, Li H, Wei Z, Hou X, Chen Y, Wen J, Li C, Zhao J, Zhang P, Wang Z, Xiao X, Bai Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair.
Li J, Dong M, Yao Q, Dong X, Chen Y, Wen J, Xu Y, Wu Z, Zhao X, Xiu Y, Zhan X, Bai Z, Xiao X
Chinese herbal medicines 2024 Jul;16(3):422-434
Chinese herbal medicines 2024 Jul;16(3):422-434
Encephalomyocarditis Virus Structural Protein VP3 Interacts with MAVS and Promotes its Autophagic Degradation to Interfere with the Type I Interferon Signaling Pathway.
Zhao X, Hou Z, Zhang Y, Mao D, Yan Z, Yang S, Xie J, Feng R
Frontiers in bioscience (Landmark edition) 2024 Jul 25;29(7):273
Frontiers in bioscience (Landmark edition) 2024 Jul 25;29(7):273
Activation of mitochondrial DNA-mediated cGAS-STING pathway contributes to chronic postsurgical pain by inducing type I interferons and A1 reactive astrocytes in the spinal cord.
Chen Y, Hu Y, He X, Zang H, Sun R, Zhu C, Yao W
International immunopharmacology 2024 Jan 25;127:111348
International immunopharmacology 2024 Jan 25;127:111348
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.
Song Y, Li H, Lian R, Dou X, Li S, Xie J, Li X, Feng R, Li Z
Viruses 2024 Jan 24;16(2)
Viruses 2024 Jan 24;16(2)
Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity.
Han J, Wang Z, Han F, Peng B, Du J, Zhang C
PLoS pathogens 2024 Feb;20(2):e1012048
PLoS pathogens 2024 Feb;20(2):e1012048
Troxerutin dampened hypothalamic neuroinflammation via microglial IL-22/IL-22R1/IRF3 activation in dihydrotestosterone-induced polycystic ovary syndrome rats.
Gao Z, Tan H, Song X, Zhuang T, Kong R, Wang Y, Yan X, Yao R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155280
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155280
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Peng D, Huang Z, Yang H, Luo Y, Wu Z
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Immunity, inflammation and disease 2024 Feb;12(2):e1189
A suitable and efficient optimization system for the culture of Chlamydia trachomatis in adult inclusion conjunctivitis.
Wei Y, Xu X, Wang L, Chen Q, Li J, Liu X, Wei Z, Pang J, Peng Y, Guo X, Cheng Z, Wang Z, Zhang Y, Chen K, Lu X, Liang Q
Pathogens and disease 2024 Feb 7;82
Pathogens and disease 2024 Feb 7;82
Double-filtration plasmapheresis reduces type I interferon bioavailability and inducing activity in systemic lupus erythematosus.
Saito T, Takatsuji R, Murayama G, Yamaji Y, Hagiwara Y, Nishioka Y, Kuga T, Miyashita T, Kusaoi M, Tamura N, Yamaji K
Immunological medicine 2024 Dec;47(4):264-274
Immunological medicine 2024 Dec;47(4):264-274
ZFP36 Facilitates Senecavirus A (SVA) replication by inhibiting the production of type I interferon.
Yin M, Guan L, Zhang M, Li X, Qian P
Virus research 2024 Dec;350:199498
Virus research 2024 Dec;350:199498
TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis.
Li Y, Ji L, Liu C, Li J, Wen D, Li Z, Yu L, Guo M, Zhang S, Duan W, Yi L, Bi Y, Bu H, Li C, Liu Y
The FEBS journal 2024 Dec;291(23):5214-5235
The FEBS journal 2024 Dec;291(23):5214-5235
Manganese improves CD8(+) T cell recruitment via cGAS-STING in hepatocellular carcinoma.
Fu C, Guo H, Wang M, Ni C, Wu X, Chen X, Hou J, Wang L
International immunopharmacology 2024 Dec 25;143(Pt 3):113591
International immunopharmacology 2024 Dec 25;143(Pt 3):113591
Ibuprofen modulates macrophage polarization by downregulating poly (ADP-ribose) polymerase 1.
Wang PH, Wang Y, Guo YY, Ma ZH, Wu C, Xing L
International immunopharmacology 2024 Dec 25;143(Pt 3):113502
International immunopharmacology 2024 Dec 25;143(Pt 3):113502
Fish Snx27 promotes viral products by modulating the innate immune response and exosomal machinery.
Yu Y, Liu J, Zhao Z, Lan X, Li L, Hu J, Zang Y-a, Zhang X, Chen J
Journal of virology 2024 Dec 17;98(12):e0097424
Journal of virology 2024 Dec 17;98(12):e0097424
Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation.
Yan Z, Yue J, Zhang Y, Hou Z, Li D, Yang Y, Li X, Idris A, Li H, Li S, Xie J, Feng R
Virologica Sinica 2024 Aug;39(4):587-599
Virologica Sinica 2024 Aug;39(4):587-599
Hunnivirus structural protein VP2 inhibits beta interferon production by targeting the IRF3 essential modulator.
Zhu X, Dong Q, Zhang K, Zou Y, Zhang G, Du Y, Mo X, Wu A, Ouyang K, Chen Y, Wei Z, Qin Y, Pan Y, Huang W
Veterinary microbiology 2024 Aug;295:110148
Veterinary microbiology 2024 Aug;295:110148
STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.
He W, Chang H, Li C, Wang C, Li L, Yang G, Chen J, Liu H
Virology journal 2024 Aug 24;21(1):197
Virology journal 2024 Aug 24;21(1):197
CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.
Li W, Guo F, Zeng R, Liang H, Wang Y, Xiong W, Wu H, Yang C, Jin X
Cancer research 2024 Aug 15;84(16):2588-2606
Cancer research 2024 Aug 15;84(16):2588-2606
Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding.
Li C, Wen J, Zhan X, Shi W, Ye X, Yao Q, Chen S, Zheng C, Wang X, Wen X, Xiao X, Wang Y, Bai Z
Chinese medicine 2024 Aug 15;19(1):107
Chinese medicine 2024 Aug 15;19(1):107
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
Zhao QX, Yan SB, Wang F, Li XX, Shang GK, Zheng ZJ, Xiao J, Lin ZW, Li CB, Ji XP
Biochemical pharmacology 2024 Apr;222:116102
Biochemical pharmacology 2024 Apr;222:116102
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
Wang K, Wen Y, Fu X, Wei S, Liu S, Chen M
Free radical biology & medicine 2024 Apr;216:80-88
Free radical biology & medicine 2024 Apr;216:80-88
Therapeutic efficacy of a novel self-assembled immunostimulatory siRNA combining apoptosis promotion with RIG-I activation in gliomas.
Chen J, Liu Z, Fang H, Su Q, Fan Y, Song L, He S
Journal of translational medicine 2024 Apr 29;22(1):395
Journal of translational medicine 2024 Apr 29;22(1):395
IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
Zheng C, Wang J, Zhou Y, Duan Y, Zheng R, Xie Y, Wei X, Wu J, Shen H, Ye M, Kong B, Liu Y, Xu P, Zhang Q, Liang T
Cell reports 2024 Apr 23;43(4):114088
Cell reports 2024 Apr 23;43(4):114088
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.
Ma X, Yin J, Qiao L, Wan H, Liu X, Zhou Y, Wu J, Niu L, Wu M, Wang X, Ye H
Molecular cell 2024 Apr 18;84(8):1585-1600.e7
Molecular cell 2024 Apr 18;84(8):1585-1600.e7
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.
Huang HX, Zhao CC, Lei XX, Zhang XY, Li YY, Lan T, Zhao BP, Lu JY, Sun WC, Lu HJ, Jin NY
Frontiers in immunology 2023;14:1196031
Frontiers in immunology 2023;14:1196031
Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis.
Luo W, Xu G, Song Z, Mu W, Wen J, Hui S, Zhao J, Zhan X, Bai Z, Xiao X
Frontiers in pharmacology 2023;14:1160445
Frontiers in pharmacology 2023;14:1160445
Japanese encephalitis virus NS4B inhibits interferon beta production by targeting TLR3 and TRIF.
Zeng Q, Liu J, Li Z, Zhang Y, Zu S, Ding X, Zhang H
Veterinary microbiology 2023 Sep;284:109849
Veterinary microbiology 2023 Sep;284:109849
Porcine reproductive and respiratory syndrome virus-mediated lactate facilitates virus replication by targeting MAVS.
Zhang L, Liu X, Mao J, Sun Y, Gao Y, Bai J, Jiang P
Veterinary microbiology 2023 Sep;284:109846
Veterinary microbiology 2023 Sep;284:109846
Role of OGDH in Atophagy-IRF3-IFN-β pathway during classical swine fever virus infection.
Zeng S, Zhu W, Luo Z, Wu K, Lu Z, Li X, Wang W, Hu W, Qin Y, Chen W, Yi L, Fan S, Chen J
International journal of biological macromolecules 2023 Sep 30;249:126443
International journal of biological macromolecules 2023 Sep 30;249:126443
4-Octyl itaconate restricts STING activation by blocking its palmitoylation.
Su C, Cheng T, Huang J, Zhang T, Yin H
Cell reports 2023 Sep 26;42(9):113040
Cell reports 2023 Sep 26;42(9):113040
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
Ouyang W, Wang S, Yan D, Wu J, Zhang Y, Li W, Hu J, Liu Z
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
The D129L protein of African swine fever virus interferes with the binding of transcriptional coactivator p300 and IRF3 to prevent beta interferon induction.
Zhang K, Ge H, Zhou P, Li L-F, Dai J, Cao H, Luo Y, Sun Y, Wang Y, Li J, Yu S, Li S, Qiu H-J
Journal of virology 2023 Oct 31;97(10):e0082423
Journal of virology 2023 Oct 31;97(10):e0082423
Naringenin Improves Innate Immune Suppression after PRRSV Infection by Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.
Yu J, Shi H, Song K, Yang Y, Li X, Peng L, Fu B, Yi P
Viruses 2023 Oct 29;15(11)
Viruses 2023 Oct 29;15(11)
Systemic administration of STING agonist promotes myeloid cells maturation and antitumor immunity through regulating hematopoietic stem and progenitor cell fate.
Xu T, Dai J, Tang L, Sun L, Si L, Guo J
Cancer immunology, immunotherapy : CII 2023 Nov;72(11):3491-3505
Cancer immunology, immunotherapy : CII 2023 Nov;72(11):3491-3505
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
Li LG, Yang XX, Xu HZ, Yu TT, Li QR, Hu J, Peng XC, Han N, Xu X, Chen NN, Chen X, Tang JM, Li TF
Advanced healthcare materials 2023 Nov;12(28):e2301561
Advanced healthcare materials 2023 Nov;12(28):e2301561
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes.
Xu H, Wang Z, Wang Y, Pan S, Zhao W, Chen M, Chen X, Tao T, Ma L, Ni Y, Li W
Cell & bioscience 2023 Nov 30;13(1):220
Cell & bioscience 2023 Nov 30;13(1):220
Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells.
Chen Z, Liu H, Zhu J, Duan X, Wang H, Li X, Zhou X, Zhao A, Yang S
Virology journal 2023 Nov 29;20(1):280
Virology journal 2023 Nov 29;20(1):280
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
Jiang A, Liu J, Wang Y, Zhang C
Free radical biology & medicine 2023 Nov 1;208:516-529
Free radical biology & medicine 2023 Nov 1;208:516-529
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
Wen J, Qin S, Li Y, Zhang P, Zhan X, Fang M, Shi C, Mu W, Kan W, Zhao J, Hui S, Hou M, Li H, Xiao X, Xu G, Bai Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion.
Yang M, Jiang H, Ding C, Zhang L, Ding N, Li G, Zhang F, Wang J, Deng L, Liu J, Xu Y
Immunity 2023 May 9;56(5):1013-1026.e6
Immunity 2023 May 9;56(5):1013-1026.e6
Japanese encephalitis virus induces apoptosis by activating the RIG-1 signaling pathway.
Gao M, Liu Z, Guo X, Zhang J, Cheng G, Hu X, Zhang W, Gu C
Archives of virology 2023 May 26;168(6):169
Archives of virology 2023 May 26;168(6):169
MGF360-12L of ASFV-SY18 is an immune-evasion protein that inhibits host type I IFN, NF-κB, and JAK/STAT pathways.
Chen Q, Wang XX, Jiang SW, Gao XT, Huang SY, Liang Y, Jia H, Zhu HF
Polish journal of veterinary sciences 2023 Mar;26(1):119-130
Polish journal of veterinary sciences 2023 Mar;26(1):119-130
IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.
Chen L, Li X, Deng Y, Bi Y, Yan Z, Yang Y, Zhang X, Li H, Xie J, Feng R
Viruses 2023 Mar 28;15(4)
Viruses 2023 Mar 28;15(4)
Prediction and Verification of Curcumin as a Potential Drug for Inhibition of PDCoV Replication in LLC-PK1 Cells.
Wang X, Wang X, Zhang J, Shan Q, Zhu Y, Xu C, Wang J
International journal of molecular sciences 2023 Mar 20;24(6)
International journal of molecular sciences 2023 Mar 20;24(6)
SARS-CoV-2 NSP13 interacts with host IRF3, blocking antiviral immune responses.
Feng K, Zhang HJ, Min YQ, Zhou M, Deng F, Wang HL, Li PQ, Ning YJ
Journal of medical virology 2023 Jun;95(6):e28881
Journal of medical virology 2023 Jun;95(6):e28881
TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Wang J, Qin X, Huang Y, Zhang Q, Pei J, Wang Y, Goren I, Ma S, Song Z, Liu Y, Xing H, Wang H, Yang B
Autophagy 2023 Jun;19(6):1844-1862
Autophagy 2023 Jun;19(6):1844-1862
Transcriptome Profiling of Vero E6 Cells during Original Parental or Cell-Attenuated Porcine Epidemic Diarrhea Virus Infection.
Peng O, Wu Y, Hu F, Xia Y, Geng R, Huang Y, Zeng S, Hu G, Xue C, Zhang H, Cao Y
Viruses 2023 Jun 23;15(7)
Viruses 2023 Jun 23;15(7)
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Tang M, Chen G, Tu B, Hu Z, Huang Y, DuFort CC, Wan X, Mao Z, Liu Y, Zhu WG, Lu W
Science advances 2023 Jun 16;9(24):eade6624
Science advances 2023 Jun 16;9(24):eade6624
Epstein-Barr Virus Envelope Glycoprotein gp110 Inhibits IKKi-Mediated Activation of NF-κB and Promotes the Degradation of β-Catenin.
Guo Y, Pan L, Wang L, Wang S, Fu J, Luo W, Wang K, Li X, Huang C, Liu Y, Kang H, Zeng Q, Fu X, Huang Z, Li W, He Y, Li L, Peng T, Yang H, Li M, Xiao B, Cai M
Microbiology spectrum 2023 Jun 15;11(3):e0032623
Microbiology spectrum 2023 Jun 15;11(3):e0032623
LncRNA ZNF593-AS alleviates diabetic cardiomyopathy via suppressing IRF3 signaling pathway.
Xie R, Fan J, Wen J, Jin K, Zhan J, Yuan S, Tang Y, Nie X, Wen Z, Li H, Chen C, Wang DW
Molecular therapy. Nucleic acids 2023 Jun 13;32:689-703
Molecular therapy. Nucleic acids 2023 Jun 13;32:689-703
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.
Qi J, Luo Q, Zhang Q, Wu M, Zhang L, Qin L, Xue Q, Nie X
Journal of ethnopharmacology 2023 Jun 12;309:116327
Journal of ethnopharmacology 2023 Jun 12;309:116327
STING deficiency protects against wasp venom-induced acute kidney injury.
Lv Y, Lu L, Yu F, Gao Z, Yuan H, Hu F
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.
Yiu SPT, Zerbe C, Vanderwall D, Huttlin EL, Weekes MP, Gewurz BE
Molecular cell 2023 Jul 6;83(13):2367-2386.e15
Molecular cell 2023 Jul 6;83(13):2367-2386.e15
STAT3 regulates antiviral immunity by suppressing excessive interferon signaling.
Liu S, Liu S, Yu Z, Zhou W, Zheng M, Gu R, Hong J, Yang Z, Chi X, Guo G, Li X, Chen N, Huang S, Wang S, Chen JL
Cell reports 2023 Jul 25;42(7):112806
Cell reports 2023 Jul 25;42(7):112806
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication.
Zhao J, Xu G, Hou X, Mu W, Yang H, Shi W, Wen J, Liu T, Wu Z, Bai J, Zhang P, Wang Z, Xiao X, Zou W, Bai Z, Zhan X
Journal of ethnopharmacology 2023 Jul 15;311:116427
Journal of ethnopharmacology 2023 Jul 15;311:116427
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING.
Hu Y, Li X, Wang D, Mao X
Molecular immunology 2023 Feb;154:45-53
Molecular immunology 2023 Feb;154:45-53
Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.
Wang J, Qin X, Huang Y, Zhang G, Liu Y, Cui Y, Wang Y, Pei J, Ma S, Song Z, Zhu X, Wang H, Yang B
Journal of virology 2023 Feb 28;97(2):e0197522
Journal of virology 2023 Feb 28;97(2):e0197522
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Jing B, Guo F, An R, Gao Y, Li Y, Xie Y, Wang J, Chen Y, Li H, Gao T, Jin Q, Zhang L, Xie M
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Journal of nanobiotechnology 2023 Feb 2;21(1):37
African swine fever virus S273R protein antagonizes type I interferon production by interfering with TBK1 and IRF3 interaction.
Li H, Zheng X, Li Y, Zhu Y, Xu Y, Yu Z, Feng WH
Virologica Sinica 2023 Dec;38(6):911-921
Virologica Sinica 2023 Dec;38(6):911-921
TBK1-stabilized ZNF268a recruits SETD4 to methylate TBK1 for efficient interferon signaling.
Liu Y, Yin W, Zeng X, Fan J, Liu C, Gao M, Huang Z, Sun G, Guo M
The Journal of biological chemistry 2023 Dec;299(12):105428
The Journal of biological chemistry 2023 Dec;299(12):105428
NSUN2-mediated M(5)c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
Wang H, Feng J, Zeng C, Liu J, Fu Z, Wang D, Wang Y, Zhang L, Li J, Jiang A, He M, Cao Y, Yan K, Tang H, Guo D, Xu K, Zhou X, Zhou L, Lan K, Zhou Y, Chen Y
Emerging microbes & infections 2023 Dec;12(1):2178238
Emerging microbes & infections 2023 Dec;12(1):2178238
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
Wen J, Mu W, Li H, Yan Y, Zhan X, Luo W, Wang Z, Kan W, Zhao J, Hui S, He P, Qin S, Xu Y, Zhang P, Xiao X, Xu G, Bai Z
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
RNF144A promotes antiviral responses by modulating STING ubiquitination.
Yang B, Pei J, Lu C, Wang Y, Shen M, Qin X, Huang Y, Yang X, Zhao X, Ma S, Song Z, Liang Y, Wang H, Wang J
EMBO reports 2023 Dec 6;24(12):e57528
EMBO reports 2023 Dec 6;24(12):e57528
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
Xu Z, Tian M, Tan Q, Hao P, Gao Z, Li C, Jin N
International journal of molecular sciences 2023 Dec 26;25(1)
International journal of molecular sciences 2023 Dec 26;25(1)
Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer.
Shen Q, Yang L, Li C, Wang T, Lv J, Liu W, Lin Y, Yin Y, Tao K
Heliyon 2023 Aug;9(8):e18954
Heliyon 2023 Aug;9(8):e18954
A transformable nanoplatform with multiple therapeutic and immunostimulatory properties for treatment of advanced cancers.
Xue X, Qu H, Bo R, Zhang D, Zhu Z, Xiang B, Li L, Ricci M, Pan CX, Lin TY, Li Y
Biomaterials 2023 Aug;299:122145
Biomaterials 2023 Aug;299:122145
Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy.
Liu Y, Chen X, Zhao Y, Wang XY, Luo YW, Chen L, Wang W, Zhong S, Hu M, Dai Z, Jiang J, Wang X, Ji H, Cheng XX, Zheng A, Zuo J, Liu H, Ma D, Luo Z, Cao F, Hu S, Huang AL, Tang KF
Cell reports 2023 Aug 29;42(8):112852
Cell reports 2023 Aug 29;42(8):112852
A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway.
Wu X, Xu L, Li X, Zhou Y, Han X, Zhang W, Wang W, Guo W, Liu W, Xu Q, Gu Y
Cell death & disease 2023 Aug 24;14(8):550
Cell death & disease 2023 Aug 24;14(8):550
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Li L, Guo C, Yu Y, Tie L, Lu G, Liu F, Han X, Ji L, Zou X
Cell & bioscience 2023 Aug 21;13(1):154
Cell & bioscience 2023 Aug 21;13(1):154
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
Liu Y, Sun Q, Zhang C, Ding M, Wang C, Zheng Q, Ma Z, Xu H, Zhou G, Wang X, Cheng Z, Xia H
iScience 2023 Aug 18;26(8):107376
iScience 2023 Aug 18;26(8):107376
WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response.
Li J, Zhang R, Wang C, Zhu J, Ren M, Jiang Y, Hou X, Du Y, Wu Q, Qi S, Li L, Chen S, Yang H, Hou F
Nature communications 2023 Aug 10;14(1):4824
Nature communications 2023 Aug 10;14(1):4824
A role of STING signaling in obesity-induced lung inflammation.
Qi Y, Wu Z, Chen D, Zhu L, Yang Y
International journal of obesity (2005) 2023 Apr;47(4):325-334
International journal of obesity (2005) 2023 Apr;47(4):325-334
DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma.
Taffoni C, Marines J, Chamma H, Guha S, Saccas M, Bouzid A, Valadao AC, Maghe C, Jardine J, Park MK, Polak K, De Martino M, Vanpouille-Box C, Del Rio M, Gongora C, Gavard J, Bidère N, Song MS, Pineau D, Hugnot JP, Kissa K, Fontenille L, Blanchet FP, Vila IK, Laguette N
The EMBO journal 2023 Apr 3;42(7):e111961
The EMBO journal 2023 Apr 3;42(7):e111961
The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1.
Diao F, Bai J, Jiang C, Sun Y, Gao Y, Nauwynck H, Jiang P, Liu X
Journal of virology 2023 Apr 27;97(4):e0018823
Journal of virology 2023 Apr 27;97(4):e0018823
Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor.
Chen NN, Zhang H, Zhu QS, Zeng T, Dai W, Zhou YL, Xin GF, Wu BD, Gong SJ, Jiang ZY, You QD, Xu XL
Journal of medicinal chemistry 2023 Apr 27;66(8):5584-5610
Journal of medicinal chemistry 2023 Apr 27;66(8):5584-5610
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
Ji W, Zhang L, Ma C, Xu X, Li S, Xia H, Zhou W, Liu X
Cell reports 2023 Apr 25;42(4):112327
Cell reports 2023 Apr 25;42(4):112327
Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.
He X, Xiao Y, Liu S, Deng R, Li Z, Zhu X
BioMed research international 2022;2022:3191474
BioMed research international 2022;2022:3191474
Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.
Kang N, Shi Y, Song J, Gao F, Fan M, Jin W, Gao Y, Lv P
Frontiers in aging neuroscience 2022;14:868484
Frontiers in aging neuroscience 2022;14:868484
Mechanism of selenomethionine inhibiting of PDCoV replication in LLC-PK1 cells based on STAT3/miR-125b-5p-1/HK2 signaling.
Ren Z, Ding T, He H, Wei Z, Shi R, Deng J
Frontiers in immunology 2022;13:952852
Frontiers in immunology 2022;13:952852
DDX56 inhibits PRV replication through regulation of IFN-β signaling pathway by targeting cGAS.
Xie J, Li X, Yang S, Yan Z, Chen L, Yang Y, Li D, Zhang X, Feng R
Frontiers in microbiology 2022;13:932842
Frontiers in microbiology 2022;13:932842
Antiviral Effect of Selenomethionine on Porcine Deltacoronavirus in Pig Kidney Epithelial Cells.
Ren Z, Jia G, He H, Ding T, Yu Y, Zuo Z, Hu Y, Zhong Z, Yu S, Deng H, Shen L, Cao S, Peng G, Wang Y, Cai D, Gou L, Ma X, Liu H, Zhou Z, Deng Y, Yang D, Deng J
Frontiers in microbiology 2022;13:846747
Frontiers in microbiology 2022;13:846747
Transcriptome Analyses of Senecavirus A-Infected PK-15 Cells: RIG-I and IRF7 Are the Important Factors in Inducing Type III Interferons.
Peng K, Deng L, Wei J, Zhao J, Deng H, Tao Q, Jiang C, Zeng Y, Li F, Zhang R, Sun X, Xu Z, Zhu L
Frontiers in microbiology 2022;13:846343
Frontiers in microbiology 2022;13:846343
Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling.
Chen J, Lu Z, Yang X, Zhou Y, Gao J, Zhang S, Huang S, Cai J, Yu J, Zhao W, Zhang B
Frontiers in cellular and infection microbiology 2022;12:899546
Frontiers in cellular and infection microbiology 2022;12:899546
Porcine Sapelovirus 3C(pro) Inhibits the Production of Type I Interferon.
Yin M, Wen W, Wang H, Zhao Q, Zhu H, Chen H, Li X, Qian P
Frontiers in cellular and infection microbiology 2022;12:852473
Frontiers in cellular and infection microbiology 2022;12:852473
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Zhao X, Yu M, Zhao Y, Zheng Y, Meng L, Du K, Xie Z, Lv H, Zhang W, Liu J, Wang Q, Yuan Y, Wang Z, Deng J
Journal of neurology 2022 Sep;269(9):4985-4996
Journal of neurology 2022 Sep;269(9):4985-4996
Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity.
Cheng Q, Yuan L, Guo J, Guo D, Liu X, Li S
The international journal of biochemistry & cell biology 2022 Sep;150:106275
The international journal of biochemistry & cell biology 2022 Sep;150:106275
NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production.
Cai Y, Zhu Y, Zheng J, Zhang Y, Chen W
Biochemical and biophysical research communications 2022 Oct 1;623:140-147
Biochemical and biophysical research communications 2022 Oct 1;623:140-147
The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1.
Sun M, Yu S, Ge H, Wang T, Li Y, Zhou P, Pan L, Han Y, Yang Y, Sun Y, Li S, Li LF, Qiu HJ
Journal of virology 2022 May 11;96(9):e0195721
Journal of virology 2022 May 11;96(9):e0195721
RUNX1 inhibits the antiviral immune response against influenza A virus through attenuating type I interferon signaling.
Hu Y, Pan Q, Zhou K, Ling Y, Wang H, Li Y
Virology journal 2022 Mar 5;19(1):39
Virology journal 2022 Mar 5;19(1):39
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
Patel SJ, Liu N, Piaker S, Gulko A, Andrade ML, Heyward FD, Sermersheim T, Edinger N, Srinivasan H, Emont MP, Westcott GP, Luther J, Chung RT, Yan S, Kumari M, Thomas R, Deleye Y, Tchernof A, White PJ, Baselli GA, Meroni M, De Jesus DF, Ahmad R, Kulkarni RN, Valenti L, Tsai L, Rosen ED
Science translational medicine 2022 Mar 23;14(637):eabh3831
Science translational medicine 2022 Mar 23;14(637):eabh3831
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Zheng X, Xiao J, Jiang Q, Zheng L, Liu C, Dong C, Zheng Y, Ni P, Zhang C, Zhang F, Zhong R, Ding H, Wang Q, Qiu Y, Gao M, Ding J, Shen N, Wei B, Wang H
The EMBO journal 2022 Mar 15;41(6):e108016
The EMBO journal 2022 Mar 15;41(6):e108016
I226R Protein of African Swine Fever Virus Is a Suppressor of Innate Antiviral Responses.
Hong J, Chi X, Yuan X, Wen F, Rai KR, Wu L, Song Z, Wang S, Guo G, Chen JL
Viruses 2022 Mar 11;14(3)
Viruses 2022 Mar 11;14(3)
HAO1-mediated oxalate metabolism promotes lung pre-metastatic niche formation by inducing neutrophil extracellular traps.
Zeng Z, Xu S, Wang F, Peng X, Zhang W, Zhan Y, Ding Y, Liu Z, Liang L
Oncogene 2022 Jul;41(29):3719-3731
Oncogene 2022 Jul;41(29):3719-3731
TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway.
Choudhury NR, Trus I, Heikel G, Wolczyk M, Szymanski J, Bolembach A, Dos Santos Pinto RM, Smith N, Trubitsyna M, Gaunt E, Digard P, Michlewski G
Nucleic acids research 2022 Jul 8;50(12):7097-7114
Nucleic acids research 2022 Jul 8;50(12):7097-7114
Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics.
Gao J, Wu Z, Zhao M, Zhang R, Li M, Sun D, Cheng H, Qi X, Shen Y, Xu Q, Chen H, Chen D, Sun Y
Acta pharmaceutica Sinica. B 2022 Jan;12(1):149-166
Acta pharmaceutica Sinica. B 2022 Jan;12(1):149-166
IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.
Chen G, Xu Y, Fan R, Liu Y, Yao Y, Jiang H, Wu Q, Li L, Chen W, Chen X
Biochemical and biophysical research communications 2022 Jan 22;589:267-274
Biochemical and biophysical research communications 2022 Jan 22;589:267-274
Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
Jie X, Chen Y, Zhao Y, Yang X, Xu Y, Wang J, Meng R, Zhang S, Dong X, Zhang T, Yang K, Xu S, Wu G
Journal for immunotherapy of cancer 2022 Feb;10(2)
Journal for immunotherapy of cancer 2022 Feb;10(2)
Induction of HOXA3 by Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I Interferon Response through Negative Regulation of HO-1 Transcription.
Feng Y, Guo X, Tian H, He Y, Li Y, Jiang X, Zheng H, Xiao S
Journal of virology 2022 Feb 9;96(3):e0186321
Journal of virology 2022 Feb 9;96(3):e0186321
An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP.
Li X, Zhu Y, Zhang X, An X, Weng M, Shi J, Wang S, Liu C, Luo S, Zheng T
The Journal of clinical investigation 2022 Feb 1;132(3)
The Journal of clinical investigation 2022 Feb 1;132(3)
Multifaceted Effects and Mechanisms of N-Acetylcysteine on Intestinal Injury in a Porcine Epidemic Diarrhea Virus-Infected Porcine Model.
Zhang Q, Li P, Li H, Yi D, Guo S, Wang L, Zhao D, Wang C, Wu T, Hou Y
Molecular nutrition & food research 2022 Dec;66(24):e2200369
Molecular nutrition & food research 2022 Dec;66(24):e2200369
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
Gao Y, Zheng X, Chang B, Lin Y, Huang X, Wang W, Ding S, Zhan W, Wang S, Xiao B, Huo L, Yu Y, Chen Y, Gong R, Wu Y, Zhang R, Zhong L, Wang X, Chen Q, Gao S, Jiang Z, Wei D, Kang T
Cell research 2022 Dec;32(12):1086-1104
Cell research 2022 Dec;32(12):1086-1104
HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection.
Li X, Xie J, Li D, Li H, Niu Y, Wu B, Yang Y, Yan Z, Zhang X, Chen L, Feng R
Viruses 2022 Aug 23;14(9)
Viruses 2022 Aug 23;14(9)
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Xu T, Dai J, Tang L, Yang L, Si L, Sheng X, Cui C, Chi Z, Kong Y, Guo J
The Journal of investigative dermatology 2022 Apr;142(4):1158-1170.e8
The Journal of investigative dermatology 2022 Apr;142(4):1158-1170.e8
Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity.
Zheng ZQ, Fu YZ, Wang SY, Xu ZS, Zou HM, Wang YY
Cell insight 2022 Apr;1(2):100014
Cell insight 2022 Apr;1(2):100014
Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection.
Xu Y, Yang Q, Xue B, Wang X, Tian R, Deng R, Chen S, Wang X, Wang L, Wang C, Chen J, You R, Liu Q, Li H, Wang J, Li X, Liu S, Yang D, Tang S, Zhu H
Journal of virology 2022 Apr 13;96(7):e0000122
Journal of virology 2022 Apr 13;96(7):e0000122
SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response.
Liu X, Wei L, Xu F, Zhao F, Huang Y, Fan Z, Mei S, Hu Y, Zhai L, Guo J, Zheng A, Cen S, Liang C, Guo F
Science signaling 2022 Apr 12;15(729):eabg8744
Science signaling 2022 Apr 12;15(729):eabg8744
HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5.
Li X, Ma R, Wu B, Niu Y, Li H, Li D, Xie J, Idris A, Feng R
Frontiers in microbiology 2021;12:788870
Frontiers in microbiology 2021;12:788870
Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation.
Xie J, Zhang X, Chen L, Bi Y, Idris A, Xu S, Li X, Zhang Y, Feng R
Frontiers in microbiology 2021;12:761282
Frontiers in microbiology 2021;12:761282
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.
Zhang N, Gao Y, Zeng Z, Luo Y, Jiang X, Zhang J, Li J, Zhang J, Gong Y, Xie C
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1827-1837
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1827-1837
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.
Zhao Y, Sui L, Wu P, Wang W, Wang Z, Yu Y, Hou Z, Tan G, Liu Q, Wang G
Signal transduction and targeted therapy 2021 Sep 1;6(1):331
Signal transduction and targeted therapy 2021 Sep 1;6(1):331
Degradation of WTAP blocks antiviral responses by reducing the m(6) A levels of IRF3 and IFNAR1 mRNA.
Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A
EMBO reports 2021 Nov 4;22(11):e52101
EMBO reports 2021 Nov 4;22(11):e52101
Inhibition of Antiviral Innate Immunity by Avibirnavirus VP3 via Blocking TBK1-TRAF3 Complex Formation and IRF3 Activation.
Deng T, Hu B, Wang X, Lin L, Zhou J, Xu Y, Yan Y, Zheng X, Zhou J
mSystems 2021 May 11;6(3)
mSystems 2021 May 11;6(3)
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Ma D, Yang M, Wang Q, Sun C, Shi H, Jing W, Bi Y, Shen X, Ma X, Qin Z, Lin Y, Zhu L, Zhao Y, Cheng Y, Han L
Science advances 2021 Mar;7(13)
Science advances 2021 Mar;7(13)
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Zhou Y, Zhao S, Gao X, Jiang S, Ma J, Wang R, Li Q, Qin L, Tong Z, Wu J, Zhao J
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
Liao Y, Liu C, Wang J, Song Y, Sabir N, Hussain T, Yao J, Luo L, Wang H, Cui Y, Yang L, Zhao D, Zhou X
Veterinary microbiology 2021 Jul;258:109126
Veterinary microbiology 2021 Jul;258:109126
SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association.
Hu YH, Wang Y, Wang F, Dong YM, Jiang WL, Wang YP, Zhong X, Ma LX
Cellular & molecular immunology 2021 Jul;18(7):1708-1717
Cellular & molecular immunology 2021 Jul;18(7):1708-1717
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Chen X, Xu Y, Tu W, Huang F, Zuo Y, Zhang HG, Jin L, Feng Q, Ren T, He J, Miao Y, Yuan Y, Zhao Q, Liu J, Zhang R, Zhu L, Qian F, Zhu C, Zheng H, Wang J
Immunology 2021 Jul;163(3):278-292
Immunology 2021 Jul;163(3):278-292
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
Zuo Q, Cheng Z, Zhang G, Xia Y, Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
Sun H, Huang Y, Mei S, Xu F, Liu X, Zhao F, Yin L, Zhang D, Wei L, Wu C, Ma S, Wang J, Cen S, Liang C, Hu S, Guo F
Cell reports 2021 Jan 5;34(1):108586
Cell reports 2021 Jan 5;34(1):108586
Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation.
Lu M, Qiu S, Zhang L, Sun Y, Bao E, Lv Y
Virus research 2021 Jan 2;291:198220
Virus research 2021 Jan 2;291:198220
Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2.
Han Y, Xie J, Xu S, Bi Y, Li X, Zhang H, Idris A, Bai J, Feng R
Journal of virology 2021 Feb 24;95(6)
Journal of virology 2021 Feb 24;95(6)
Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl(4)/2-AAF.
Xu Y, Xu W, Liu W, Chen G, Jiang S, Chen J, Jian X, Zhang H, Liu P, Mu Y
Pharmaceutical biology 2021 Dec;59(1):1150-1160
Pharmaceutical biology 2021 Dec;59(1):1150-1160
African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.
Yang K, Huang Q, Wang R, Zeng Y, Cheng M, Xue Y, Shi C, Ye L, Yang W, Jiang Y, Wang J, Huang H, Cao X, Yang G, Wang C
Veterinary microbiology 2021 Dec;263:109265
Veterinary microbiology 2021 Dec;263:109265
SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5.
Wang DP, Zhang HY, Liao BW, Tong Z, Xu ZS, Wang YY, Yang Y
Virologica Sinica 2021 Apr;36(2):231-240
Virologica Sinica 2021 Apr;36(2):231-240
Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3.
Wang P, Deng Y, Guo Y, Xu Z, Li Y, Ou X, Xie L, Lu M, Zhong J, Li B, Hu L, Deng S, Peng T, Cai M, Li M
Frontiers in immunology 2020;11:513383
Frontiers in immunology 2020;11:513383
Nuclear transporter karyopherin subunit alpha 3 levels modulate Porcine circovirus type 2 replication in PK-15 cells.
Zhang L, Qiu S, Lu M, Huang C, Lv Y
Virology 2020 Sep;548:31-38
Virology 2020 Sep;548:31-38
PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.
Bo Z, Miao Y, Xi R, Zhong Q, Bao C, Chen H, Sun L, Qian Y, Jung YS, Dai J
Veterinary research 2020 Sep 15;51(1):118
Veterinary research 2020 Sep 15;51(1):118
Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
Lou Y, Han M, Liu H, Niu Y, Liang Y, Guo J, Zhang W, Wang H
Cellular & molecular immunology 2020 Oct;17(10):1053-1062
Cellular & molecular immunology 2020 Oct;17(10):1053-1062
The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action.
Min YQ, Shi C, Yao T, Feng K, Mo Q, Deng F, Wang H, Ning YJ
ACS infectious diseases 2020 May 8;6(5):857-870
ACS infectious diseases 2020 May 8;6(5):857-870
Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response.
Zou HM, Huang ZF, Yang Y, Luo WW, Wang SY, Luo MH, Fu YZ, Wang YY
Journal of virology 2020 Jun 1;94(12)
Journal of virology 2020 Jun 1;94(12)
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Jauhari A, Baranov SV, Suofu Y, Kim J, Singh T, Yablonska S, Li F, Wang X, Oberly P, Minnigh MB, Poloyac SM, Carlisle DL, Friedlander RM
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production.
Chen K, Xiao F, Hu D, Ge W, Tian M, Wang W, Pan P, Wu K, Wu J
Viruses 2020 Dec 30;13(1)
Viruses 2020 Dec 30;13(1)
The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes.
Hu HQ, Qiao JT, Liu FQ, Wang JB, Sha S, He Q, Cui C, Song J, Zang N, Wang LS, Sun Z, Chen L, Hou XG
Molecular and cellular endocrinology 2020 Dec 1;518:110890
Molecular and cellular endocrinology 2020 Dec 1;518:110890
Silica particles disorganize the polarization of pulmonary macrophages in mice.
Zhao Y, Hao C, Bao L, Wang D, Li Y, Qu Y, Ding M, Zhao A, Yao W
Ecotoxicology and environmental safety 2020 Apr 15;193:110364
Ecotoxicology and environmental safety 2020 Apr 15;193:110364
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, Sun T
Nutrition & metabolism 2019;16:87
Nutrition & metabolism 2019;16:87
Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study.
Chavez-Valdez R, Mottahedin A, Stridh L, Yellowhair TR, Jantzie LL, Northington FJ, Mallard C
Frontiers in physiology 2019;10:306
Frontiers in physiology 2019;10:306
Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation.
Guan X, Zhang M, Fu M, Luo S, Hu Q
Frontiers in immunology 2019;10:290
Frontiers in immunology 2019;10:290
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
Zhu W, Li J, Zhang R, Cai Y, Wang C, Qi S, Chen S, Liang X, Qi N, Hou F
The EMBO journal 2019 Sep 16;38(18):e102075
The EMBO journal 2019 Sep 16;38(18):e102075
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Hu S, Sun H, Yin L, Li J, Mei S, Xu F, Wu C, Liu X, Zhao F, Zhang D, Huang Y, Ren L, Cen S, Wang J, Liang C, Guo F
Science signaling 2019 Nov 26;12(609)
Science signaling 2019 Nov 26;12(609)
A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.
Wan W, Wang L, Chen X, Zhu S, Shang W, Xiao G, Zhang LK
Molecules (Basel, Switzerland) 2019 Nov 20;24(23)
Molecules (Basel, Switzerland) 2019 Nov 20;24(23)
ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J
Cell death and differentiation 2019 Jun;26(6):1077-1088
Cell death and differentiation 2019 Jun;26(6):1077-1088
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Zierhut C, Yamaguchi N, Paredes M, Luo JD, Carroll T, Funabiki H
Cell 2019 Jul 11;178(2):302-315.e23
Cell 2019 Jul 11;178(2):302-315.e23
Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3.
Yang Q, Tang J, Pei R, Gao X, Guo J, Xu C, Wang Y, Wang Q, Wu C, Zhou Y, Hu X, Zhao H, Wang Y, Chen X, Chen J
Journal of molecular cell biology 2019 Feb 1;11(2):158-169
Journal of molecular cell biology 2019 Feb 1;11(2):158-169
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, Wang F, Zhu C, Liu W, Cheng Z, Zhu Y, Zhou L, Zhang Y, Lu M, Liu S
PLoS pathogens 2019 Aug;15(8):e1008002
PLoS pathogens 2019 Aug;15(8):e1008002
Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.
Sanjo H, Nakayama J, Yoshizawa T, Fehling HJ, Akira S, Taki S
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):783-788
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):783-788
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
Gao X, Chen D, Hu X, Zhou Y, Wang Y, Wu C, Chen J, Wang Y, Pei R, Chen X
Journal of innate immunity 2018;10(4):315-327
Journal of innate immunity 2018;10(4):315-327
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
Cao Q, Juan CX, Zhang DQ, He J, Cao YZ, Pasha AB, Wang JY, Qi HX, Li S, Jin R, Zhou GP
Experimental cell research 2018 Sep 15;370(2):498-505
Experimental cell research 2018 Sep 15;370(2):498-505
USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.
Cai J, Chen HY, Peng SJ, Meng JL, Wang Y, Zhou Y, Qian XP, Sun XY, Pang XW, Zhang Y, Zhang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5238-5249
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5238-5249
Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China 2018/1.
Wang X, Wu J, Wu Y, Chen H, Zhang S, Li J, Xin T, Jia H, Hou S, Jiang Y, Zhu H, Guo X
Biochemical and biophysical research communications 2018 Nov 30;506(3):437-443
Biochemical and biophysical research communications 2018 Nov 30;506(3):437-443
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y
Nature communications 2018 Mar 28;9(1):1243
Nature communications 2018 Mar 28;9(1):1243
Dampened STING-Dependent Interferon Activation in Bats.
Xie J, Li Y, Shen X, Goh G, Zhu Y, Cui J, Wang LF, Shi ZL, Zhou P
Cell host & microbe 2018 Mar 14;23(3):297-301.e4
Cell host & microbe 2018 Mar 14;23(3):297-301.e4
Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity.
Zheng Z, Yang J, Jiang X, Liu Y, Zhang X, Li M, Zhang M, Fu M, Hu K, Wang H, Luo MH, Gong P, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 1;201(1):53-68
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 1;201(1):53-68
PTEN-L promotes type I interferon responses and antiviral immunity.
Cao Y, Wang H, Yang L, Zhang Z, Li C, Yuan X, Bu L, Chen L, Chen Y, Li CM, Guo D
Cellular & molecular immunology 2018 Jan;15(1):48-57
Cellular & molecular immunology 2018 Jan;15(1):48-57
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.
Yi C, Zhao Z, Wang S, Sun X, Zhang D, Sun X, Zhang A, Jin M
Frontiers in immunology 2017;8:1051
Frontiers in immunology 2017;8:1051
The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection.
Chunfa L, Xin S, Qiang L, Sreevatsan S, Yang L, Zhao D, Zhou X
Frontiers in cellular and infection microbiology 2017;7:169
Frontiers in cellular and infection microbiology 2017;7:169
Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.
Jiang Z, Song F, Li Y, Xue D, Deng G, Li M, Liu X, Wang Y
Mediators of inflammation 2017;2017:9891673
Mediators of inflammation 2017;2017:9891673
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.
Zhang HL, Ye HQ, Liu SQ, Deng CL, Li XD, Shi PY, Zhang B
Journal of virology 2017 Sep 15;91(18)
Journal of virology 2017 Sep 15;91(18)
Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.
Zhao M, Wan B, Li H, He J, Chen X, Wang L, Wang Y, Xie S, Qiao S, Zhang G
Microbial pathogenesis 2017 Oct;111:14-21
Microbial pathogenesis 2017 Oct;111:14-21
Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.
Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P
The Biochemical journal 2017 Mar 15;474(7):1163-1174
The Biochemical journal 2017 Mar 15;474(7):1163-1174
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Lang X, Tang T, Jin T, Ding C, Zhou R, Jiang W
The Journal of experimental medicine 2017 Feb;214(2):459-473
The Journal of experimental medicine 2017 Feb;214(2):459-473
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Song S, Peng P, Tang Z, Zhao J, Wu W, Li H, Shao M, Li L, Yang C, Duan F, Zhang M, Zhang J, Wu H, Li C, Wang X, Wang H, Ruan Y, Gu J
Scientific reports 2017 Feb 8;7:39858
Scientific reports 2017 Feb 8;7:39858
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314
Oncotarget 2017 Dec 29;8(70):115304-115314
GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.
Nie Y, Ran Y, Zhang HY, Huang ZF, Pan ZY, Wang SY, Wang YY
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PLoS pathogens 2017 Apr;13(4):e1006328
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Li S, Zhu M, Pan R, Fang T, Cao YY, Chen S, Zhao X, Lei CQ, Guo L, Chen Y, Li CM, Jokitalo E, Yin Y, Shu HB, Guo D
Nature immunology 2016 Mar;17(3):241-9
Nature immunology 2016 Mar;17(3):241-9
AIM2 inhibits autophagy and IFN-β production during M. bovis infection.
Liu C, Yue R, Yang Y, Cui Y, Yang L, Zhao D, Zhou X
Oncotarget 2016 Jul 26;7(30):46972-46987
Oncotarget 2016 Jul 26;7(30):46972-46987
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Journal of virology 2016 Jul 15;90(14):6573-6582
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Journal of neurochemistry 2016 Feb;136(4):871-883
Journal of neurochemistry 2016 Feb;136(4):871-883
Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.
Zhang X, Zheng Z, Liu X, Shu B, Mao P, Bai B, Hu Q, Luo M, Ma X, Cui Z, Wang H
Journal of neuroinflammation 2016 Aug 30;13(1):209
Journal of neuroinflammation 2016 Aug 30;13(1):209
Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
Li M, Guo S, Zhang P, Gong J, Zheng A, Zhang Y, Li H
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Journal of neurochemistry 2015 Jul;134(2):211-21
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.
Zhu M, Fang T, Li S, Meng K, Guo D
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Journal of immunology (Baltimore, Md. : 1950) 2015 Jul 1;195(1):289-97
HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter.
Zhang M, Liu Y, Wang P, Guan X, He S, Luo S, Li C, Hu K, Jin W, Du T, Yan Y, Zhang Z, Zheng Z, Wang H, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3102-15
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3102-15
An alternative splicing isoform of MITA antagonizes MITA-mediated induction of type I IFNs.
Chen H, Pei R, Zhu W, Zeng R, Wang Y, Wang Y, Lu M, Chen X
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 1;192(3):1162-70
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 1;192(3):1162-70
Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage.
Gu M, Zhang T, lin W, Liu Z, Lai R, Xia D, Huang H, Wang X
Cellular signalling 2014 Dec;26(12):2930-9
Cellular signalling 2014 Dec;26(12):2930-9
HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.
Guo R, Li Y, Ning J, Sun D, Lin L, Liu X
PloS one 2013;8(4):e62729
PloS one 2013;8(4):e62729
Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I.
Luo H, Zhang Z, Zheng Z, Ke X, Zhang X, Li Q, Liu Y, Bai B, Mao P, Hu Q, Wang H
Journal of immunology (Baltimore, Md. : 1950) 2013 Jul 15;191(2):660-9
Journal of immunology (Baltimore, Md. : 1950) 2013 Jul 15;191(2):660-9
Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities.
Zhou P, Li H, Wang H, Wang LF, Shi Z
The Journal of general virology 2012 Feb;93(Pt 2):275-281
The Journal of general virology 2012 Feb;93(Pt 2):275-281
Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.
Zhang Z, Zheng Z, Luo H, Meng J, Li H, Li Q, Zhang X, Ke X, Bai B, Mao P, Hu Q, Wang H
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 1;189(3):1144-53
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 1;189(3):1144-53
Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3.
Zhu H, Zheng C, Xing J, Wang S, Li S, Lin R, Mossman KL
Journal of virology 2011 Nov;85(21):11079-89
Journal of virology 2011 Nov;85(21):11079-89
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 11312-1-AP(IRF3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using IRF3 antibody 11312-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 11312-1-AP(IRF3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 11312-1-AP(IRF3 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
