Antibody data
- Antibody Data
- Antigen structure
- References [73]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 11312-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11312-1-AP, RRID:AB_2127004
- Product name
- IRF3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IRF3 antibody (Cat. #11312-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation.
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.
Degradation of WTAP blocks antiviral responses by reducing the m6 A levels of IRF3 and IFNAR1 mRNA.
Inhibition of Antiviral Innate Immunity by Avibirnavirus VP3 via Blocking TBK1-TRAF3 Complex Formation and IRF3 Activation.
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association.
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation.
Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2.
Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl4/2-AAF.
African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.
Induction of HOXA3 by PRRSV inhibits IFN-I response through negatively regulation of HO-1 transcription.
SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5.
Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3.
Nuclear transporter karyopherin subunit alpha 3 levels modulate Porcine circovirus type 2 replication in PK-15 cells.
PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.
Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action.
Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response.
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production.
The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes.
Silica particles disorganize the polarization of pulmonary macrophages in mice.
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study.
Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation.
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.
ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3.
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.
Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China 2018/1.
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Dampened STING-Dependent Interferon Activation in Bats.
PTEN-L promotes type I interferon responses and antiviral immunity.
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.
Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.
Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.
Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response.
Attenuation of cerebral ischemic injury in interferon regulatory factor 3-deficient rat.
Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.
Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.
HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter.
An alternative splicing isoform of MITA antagonizes MITA-mediated induction of type I IFNs.
Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage.
HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.
Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I.
Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities.
Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.
Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3.
Xie J, Zhang X, Chen L, Bi Y, Idris A, Xu S, Li X, Zhang Y, Feng R
Frontiers in microbiology 2021;12:761282
Frontiers in microbiology 2021;12:761282
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.
Zhang N, Gao Y, Zeng Z, Luo Y, Jiang X, Zhang J, Li J, Zhang J, Gong Y, Xie C
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1827-1837
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Sep;23(9):1827-1837
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Xu T, Dai J, Tang L, Yang L, Si L, Sheng X, Cui C, Chi Z, Kong Y, Guo J
The Journal of investigative dermatology 2021 Sep 25;
The Journal of investigative dermatology 2021 Sep 25;
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.
Zhao Y, Sui L, Wu P, Wang W, Wang Z, Yu Y, Hou Z, Tan G, Liu Q, Wang G
Signal transduction and targeted therapy 2021 Sep 1;6(1):331
Signal transduction and targeted therapy 2021 Sep 1;6(1):331
Degradation of WTAP blocks antiviral responses by reducing the m6 A levels of IRF3 and IFNAR1 mRNA.
Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A
EMBO reports 2021 Nov 4;22(11):e52101
EMBO reports 2021 Nov 4;22(11):e52101
Inhibition of Antiviral Innate Immunity by Avibirnavirus VP3 via Blocking TBK1-TRAF3 Complex Formation and IRF3 Activation.
Deng T, Hu B, Wang X, Lin L, Zhou J, Xu Y, Yan Y, Zheng X, Zhou J
mSystems 2021 May 11;6(3)
mSystems 2021 May 11;6(3)
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Ma D, Yang M, Wang Q, Sun C, Shi H, Jing W, Bi Y, Shen X, Ma X, Qin Z, Lin Y, Zhu L, Zhao Y, Cheng Y, Han L
Science advances 2021 Mar;7(13)
Science advances 2021 Mar;7(13)
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Zhou Y, Zhao S, Gao X, Jiang S, Ma J, Wang R, Li Q, Qin L, Tong Z, Wu J, Zhao J
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
Liao Y, Liu C, Wang J, Song Y, Sabir N, Hussain T, Yao J, Luo L, Wang H, Cui Y, Yang L, Zhao D, Zhou X
Veterinary microbiology 2021 Jul;258:109126
Veterinary microbiology 2021 Jul;258:109126
SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association.
Hu YH, Wang Y, Wang F, Dong YM, Jiang WL, Wang YP, Zhong X, Ma LX
Cellular & molecular immunology 2021 Jul;18(7):1708-1717
Cellular & molecular immunology 2021 Jul;18(7):1708-1717
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Chen X, Xu Y, Tu W, Huang F, Zuo Y, Zhang HG, Jin L, Feng Q, Ren T, He J, Miao Y, Yuan Y, Zhao Q, Liu J, Zhang R, Zhu L, Qian F, Zhu C, Zheng H, Wang J
Immunology 2021 Jul;163(3):278-292
Immunology 2021 Jul;163(3):278-292
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
Zuo Q, Cheng Z, Zhang G, Xia Y, Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
Sun H, Huang Y, Mei S, Xu F, Liu X, Zhao F, Yin L, Zhang D, Wei L, Wu C, Ma S, Wang J, Cen S, Liang C, Hu S, Guo F
Cell reports 2021 Jan 5;34(1):108586
Cell reports 2021 Jan 5;34(1):108586
Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation.
Lu M, Qiu S, Zhang L, Sun Y, Bao E, Lv Y
Virus research 2021 Jan 2;291:198220
Virus research 2021 Jan 2;291:198220
Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2.
Han Y, Xie J, Xu S, Bi Y, Li X, Zhang H, Idris A, Bai J, Feng R
Journal of virology 2021 Feb 24;95(6)
Journal of virology 2021 Feb 24;95(6)
Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl4/2-AAF.
Xu Y, Xu W, Liu W, Chen G, Jiang S, Chen J, Jian X, Zhang H, Liu P, Mu Y
Pharmaceutical biology 2021 Dec;59(1):1150-1160
Pharmaceutical biology 2021 Dec;59(1):1150-1160
African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.
Yang K, Huang Q, Wang R, Zeng Y, Cheng M, Xue Y, Shi C, Ye L, Yang W, Jiang Y, Wang J, Huang H, Cao X, Yang G, Wang C
Veterinary microbiology 2021 Dec;263:109265
Veterinary microbiology 2021 Dec;263:109265
Induction of HOXA3 by PRRSV inhibits IFN-I response through negatively regulation of HO-1 transcription.
Feng Y, Guo X, Tian H, He Y, Li Y, Jiang X, Zheng H, Xiao S
Journal of virology 2021 Dec 1;:JVI0186321
Journal of virology 2021 Dec 1;:JVI0186321
SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5.
Wang DP, Zhang HY, Liao BW, Tong Z, Xu ZS, Wang YY, Yang Y
Virologica Sinica 2021 Apr;36(2):231-240
Virologica Sinica 2021 Apr;36(2):231-240
Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3.
Wang P, Deng Y, Guo Y, Xu Z, Li Y, Ou X, Xie L, Lu M, Zhong J, Li B, Hu L, Deng S, Peng T, Cai M, Li M
Frontiers in immunology 2020;11:513383
Frontiers in immunology 2020;11:513383
Nuclear transporter karyopherin subunit alpha 3 levels modulate Porcine circovirus type 2 replication in PK-15 cells.
Zhang L, Qiu S, Lu M, Huang C, Lv Y
Virology 2020 Sep;548:31-38
Virology 2020 Sep;548:31-38
PRV UL13 inhibits cGAS-STING-mediated IFN-β production by phosphorylating IRF3.
Bo Z, Miao Y, Xi R, Zhong Q, Bao C, Chen H, Sun L, Qian Y, Jung YS, Dai J
Veterinary research 2020 Sep 15;51(1):118
Veterinary research 2020 Sep 15;51(1):118
Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
Lou Y, Han M, Liu H, Niu Y, Liang Y, Guo J, Zhang W, Wang H
Cellular & molecular immunology 2020 Oct;17(10):1053-1062
Cellular & molecular immunology 2020 Oct;17(10):1053-1062
The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action.
Min YQ, Shi C, Yao T, Feng K, Mo Q, Deng F, Wang H, Ning YJ
ACS infectious diseases 2020 May 8;6(5):857-870
ACS infectious diseases 2020 May 8;6(5):857-870
Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response.
Zou HM, Huang ZF, Yang Y, Luo WW, Wang SY, Luo MH, Fu YZ, Wang YY
Journal of virology 2020 Jun 1;94(12)
Journal of virology 2020 Jun 1;94(12)
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Jauhari A, Baranov SV, Suofu Y, Kim J, Singh T, Yablonska S, Li F, Wang X, Oberly P, Minnigh MB, Poloyac SM, Carlisle DL, Friedlander RM
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production.
Chen K, Xiao F, Hu D, Ge W, Tian M, Wang W, Pan P, Wu K, Wu J
Viruses 2020 Dec 30;13(1)
Viruses 2020 Dec 30;13(1)
The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes.
Hu HQ, Qiao JT, Liu FQ, Wang JB, Sha S, He Q, Cui C, Song J, Zang N, Wang LS, Sun Z, Chen L, Hou XG
Molecular and cellular endocrinology 2020 Dec 1;518:110890
Molecular and cellular endocrinology 2020 Dec 1;518:110890
Silica particles disorganize the polarization of pulmonary macrophages in mice.
Zhao Y, Hao C, Bao L, Wang D, Li Y, Qu Y, Ding M, Zhao A, Yao W
Ecotoxicology and environmental safety 2020 Apr 15;193:110364
Ecotoxicology and environmental safety 2020 Apr 15;193:110364
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, Sun T
Nutrition & metabolism 2019;16:87
Nutrition & metabolism 2019;16:87
Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study.
Chavez-Valdez R, Mottahedin A, Stridh L, Yellowhair TR, Jantzie LL, Northington FJ, Mallard C
Frontiers in physiology 2019;10:306
Frontiers in physiology 2019;10:306
Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation.
Guan X, Zhang M, Fu M, Luo S, Hu Q
Frontiers in immunology 2019;10:290
Frontiers in immunology 2019;10:290
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
Zhu W, Li J, Zhang R, Cai Y, Wang C, Qi S, Chen S, Liang X, Qi N, Hou F
The EMBO journal 2019 Sep 16;38(18):e102075
The EMBO journal 2019 Sep 16;38(18):e102075
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Hu S, Sun H, Yin L, Li J, Mei S, Xu F, Wu C, Liu X, Zhao F, Zhang D, Huang Y, Ren L, Cen S, Wang J, Liang C, Guo F
Science signaling 2019 Nov 26;12(609)
Science signaling 2019 Nov 26;12(609)
A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.
Wan W, Wang L, Chen X, Zhu S, Shang W, Xiao G, Zhang LK
Molecules (Basel, Switzerland) 2019 Nov 20;24(23)
Molecules (Basel, Switzerland) 2019 Nov 20;24(23)
ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J
Cell death and differentiation 2019 Jun;26(6):1077-1088
Cell death and differentiation 2019 Jun;26(6):1077-1088
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Zierhut C, Yamaguchi N, Paredes M, Luo JD, Carroll T, Funabiki H
Cell 2019 Jul 11;178(2):302-315.e23
Cell 2019 Jul 11;178(2):302-315.e23
Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3.
Yang Q, Tang J, Pei R, Gao X, Guo J, Xu C, Wang Y, Wang Q, Wu C, Zhou Y, Hu X, Zhao H, Wang Y, Chen X, Chen J
Journal of molecular cell biology 2019 Feb 1;11(2):158-169
Journal of molecular cell biology 2019 Feb 1;11(2):158-169
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, Wang F, Zhu C, Liu W, Cheng Z, Zhu Y, Zhou L, Zhang Y, Lu M, Liu S
PLoS pathogens 2019 Aug;15(8):e1008002
PLoS pathogens 2019 Aug;15(8):e1008002
Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.
Sanjo H, Nakayama J, Yoshizawa T, Fehling HJ, Akira S, Taki S
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):783-788
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):783-788
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
Gao X, Chen D, Hu X, Zhou Y, Wang Y, Wu C, Chen J, Wang Y, Pei R, Chen X
Journal of innate immunity 2018;10(4):315-327
Journal of innate immunity 2018;10(4):315-327
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
Cao Q, Juan CX, Zhang DQ, He J, Cao YZ, Pasha AB, Wang JY, Qi HX, Li S, Jin R, Zhou GP
Experimental cell research 2018 Sep 15;370(2):498-505
Experimental cell research 2018 Sep 15;370(2):498-505
USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling.
Cai J, Chen HY, Peng SJ, Meng JL, Wang Y, Zhou Y, Qian XP, Sun XY, Pang XW, Zhang Y, Zhang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5238-5249
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5238-5249
Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China 2018/1.
Wang X, Wu J, Wu Y, Chen H, Zhang S, Li J, Xin T, Jia H, Hou S, Jiang Y, Zhu H, Guo X
Biochemical and biophysical research communications 2018 Nov 30;506(3):437-443
Biochemical and biophysical research communications 2018 Nov 30;506(3):437-443
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y
Nature communications 2018 Mar 28;9(1):1243
Nature communications 2018 Mar 28;9(1):1243
Dampened STING-Dependent Interferon Activation in Bats.
Xie J, Li Y, Shen X, Goh G, Zhu Y, Cui J, Wang LF, Shi ZL, Zhou P
Cell host & microbe 2018 Mar 14;23(3):297-301.e4
Cell host & microbe 2018 Mar 14;23(3):297-301.e4
PTEN-L promotes type I interferon responses and antiviral immunity.
Cao Y, Wang H, Yang L, Zhang Z, Li C, Yuan X, Bu L, Chen L, Chen Y, Li CM, Guo D
Cellular & molecular immunology 2018 Jan;15(1):48-57
Cellular & molecular immunology 2018 Jan;15(1):48-57
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.
Yi C, Zhao Z, Wang S, Sun X, Zhang D, Sun X, Zhang A, Jin M
Frontiers in immunology 2017;8:1051
Frontiers in immunology 2017;8:1051
Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.
Jiang Z, Song F, Li Y, Xue D, Deng G, Li M, Liu X, Wang Y
Mediators of inflammation 2017;2017:9891673
Mediators of inflammation 2017;2017:9891673
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.
Zhang HL, Ye HQ, Liu SQ, Deng CL, Li XD, Shi PY, Zhang B
Journal of virology 2017 Sep 15;91(18)
Journal of virology 2017 Sep 15;91(18)
Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.
Zhao M, Wan B, Li H, He J, Chen X, Wang L, Wang Y, Xie S, Qiao S, Zhang G
Microbial pathogenesis 2017 Oct;111:14-21
Microbial pathogenesis 2017 Oct;111:14-21
Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.
Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P
The Biochemical journal 2017 Mar 15;474(7):1163-1174
The Biochemical journal 2017 Mar 15;474(7):1163-1174
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Lang X, Tang T, Jin T, Ding C, Zhou R, Jiang W
The Journal of experimental medicine 2017 Feb;214(2):459-473
The Journal of experimental medicine 2017 Feb;214(2):459-473
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Song S, Peng P, Tang Z, Zhao J, Wu W, Li H, Shao M, Li L, Yang C, Duan F, Zhang M, Zhang J, Wu H, Li C, Wang X, Wang H, Ruan Y, Gu J
Scientific reports 2017 Feb 8;7:39858
Scientific reports 2017 Feb 8;7:39858
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314
Oncotarget 2017 Dec 29;8(70):115304-115314
GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.
Nie Y, Ran Y, Zhang HY, Huang ZF, Pan ZY, Wang SY, Wang YY
PLoS pathogens 2017 Apr;13(4):e1006328
PLoS pathogens 2017 Apr;13(4):e1006328
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Li S, Zhu M, Pan R, Fang T, Cao YY, Chen S, Zhao X, Lei CQ, Guo L, Chen Y, Li CM, Jokitalo E, Yin Y, Shu HB, Guo D
Nature immunology 2016 Mar;17(3):241-9
Nature immunology 2016 Mar;17(3):241-9
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response.
Zeng LP, Gao YT, Ge XY, Zhang Q, Peng C, Yang XL, Tan B, Chen J, Chmura AA, Daszak P, Shi ZL
Journal of virology 2016 Jul 15;90(14):6573-6582
Journal of virology 2016 Jul 15;90(14):6573-6582
Attenuation of cerebral ischemic injury in interferon regulatory factor 3-deficient rat.
Li L, Qin JJ, Guo S, Zhang P, Gong J, Zhang XJ, Zheng A, Xia H, Li H
Journal of neurochemistry 2016 Feb;136(4):871-883
Journal of neurochemistry 2016 Feb;136(4):871-883
Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.
Zhang X, Zheng Z, Liu X, Shu B, Mao P, Bai B, Hu Q, Luo M, Ma X, Cui Z, Wang H
Journal of neuroinflammation 2016 Aug 30;13(1):209
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Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
Li M, Guo S, Zhang P, Gong J, Zheng A, Zhang Y, Li H
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HSV-2 immediate-early protein US1 inhibits IFN-β production by suppressing association of IRF-3 with IFN-β promoter.
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Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 1;192(3):1162-70
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Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I.
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Journal of immunology (Baltimore, Md. : 1950) 2013 Jul 15;191(2):660-9
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Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.
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Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3.
Zhu H, Zheng C, Xing J, Wang S, Li S, Lin R, Mossman KL
Journal of virology 2011 Nov;85(21):11079-89
Journal of virology 2011 Nov;85(21):11079-89
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 11312-1-AP(IRF3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using IRF3 antibody 11312-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 11312-1-AP(IRF3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 11312-1-AP(IRF3 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue