Antibody data
- Antibody Data
- Antigen structure
- References [40]
- Comments [0]
- Validations [0]
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- Product number
- 66670-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- IRF3 antibody
- Antibody type
- Monoclonal
- Description
- IRF3 antibody (Cat. #66670-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1E6G8
- Vial size
- 20ul, 150ul
Submitted references Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation.
Synergistic reprogramming of the tumor immune microenvironment by Senecavirus A and STING agonist.
STING Drives Psoriatic Inflammation by Promoting Neutrophil Recruitment and Facilitating NETosis.
Ursodeoxycholic acid inhibits pneumonia caused by PRCV through the activation of TLR4-IRF3 mediated type Ⅰ interferon pathway.
SARS-CoV-2 spike protein induces depressive-like behaviors by disrupting astrocytic Cx43-mediated gap junction intercellular communication.
Recurrent severe viral infection in a child with inherited complete TBK1 deficiency.
CDK10 suppresses nucleic acid sensors-mediated antitumor immunity.
Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway.
Single-cell sequencing-guided design of synergistic chemo-immunotherapy nanodrugs for cGAS-STING activation in prostate cancer therapy.
Ultrasound-triggered carrier-free nanoprodrugs activate cGAS-STING pathway to enhance tumor-targeting chemo-immunotherapy.
HDAC7 knockout mitigates astrocyte reactivity and neuroinflammation via the IRF3/cGAS/STING signaling pathway.
The role and mechanism of the cGAS-STING pathway-mediated ROS in apoptosis and ferroptosis induced by manganese exposure.
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription.
African swine fever virus pMGF505-9R enhances RIG-I-like receptor signaling by promoting RING finger protein 125 autoubiquitination.
GALNT6 dual regulates innate immunity STING signaling and PD-L1 expression to promote immune evasion in pancreatic ductal adenocarcinoma.
Sclareol can effectively ameliorate Feline calicivirus induced lung injury via the inhibition of inflammation and apoptosis.
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation.
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery.
The activation of cGAS-STING pathway promotes the epithelial-mesenchymal transition and inflammation in intrauterine adhesion.
SADS-CoV nsp5 Inhibits Interferon Production by Targeting Kinase IKKε.
Endogenous nanoplatforms for tumor photoimmunotherapy: Hypoxia modulation and STING pathway activation.
Nanodrug Modulates Premetastatic Niche and Suppresses Metastatic Lung Adenocarcinoma via Programmed Cell Death Ligand 1 Blockade and STING Pathway Activation.
Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects.
XBP1 promotes endometrial fibrosis through cGAS-STING signaling pathway in intrauterine adhesion.
Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse.
CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine.
CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer.
An Immune Subtype Classification System Enables the Development of Strategies to Predict and Enhance Immunotherapy Responses in Colorectal Cancer.
Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
IDI1 inhibits the cGAS-Sting signaling pathway in hepatocellular carcinoma.
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Anemoside B4 inhibits SARS-CoV-2 replication in vitro and in vivo.
Targeting TRAF6/IRF3 axis to inhibit NF-κB-p65 nuclear translocation enhances the chemosensitivity of 5-FU and reverses the proliferation of gastric cancer.
SADS-CoV nsp1 inhibits the IFN-β production by preventing TBK1 phosphorylation and inducing CBP degradation.
Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis.
Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis.
DDX56 antagonizes IFN-β production to enhance EMCV replication by inhibiting IRF3 nuclear translocation.
MIR155HG Plays a Bivalent Role in Regulating Innate Antiviral Immunity by Encoding Long Noncoding RNA-155 and microRNA-155-5p.
Swine Acute Diarrhea Syndrome Coronavirus Nucleocapsid Protein Antagonizes Interferon-β Production via Blocking the Interaction Between TRAF3 and TBK1.
Wang SS, Yuan RL, Wang WF, Peng Y, Hu KC, He WB, Zhao YX, Yan X, Zhang Z, Chu SF, Chen NH
Journal of advanced research 2026 May;83:315-332
Journal of advanced research 2026 May;83:315-332
Synergistic reprogramming of the tumor immune microenvironment by Senecavirus A and STING agonist.
Zhao X, Gao L, Chen R, Tian H, Liang S, Zhang Z, Li W, Sun J, Chen X, Tang X, Lan T, Sun Y, Ma J
Oncogene 2026 Mar;45(9):809-822
Oncogene 2026 Mar;45(9):809-822
STING Drives Psoriatic Inflammation by Promoting Neutrophil Recruitment and Facilitating NETosis.
Luo H, Hu C, Tian T, Qian T, Jiang X, Dang Y, Chen B, Yang Z, Luo N, Zhang D, Hao F
Immunology 2026 Mar 3;
Immunology 2026 Mar 3;
Ursodeoxycholic acid inhibits pneumonia caused by PRCV through the activation of TLR4-IRF3 mediated type Ⅰ interferon pathway.
Zhang X, Liao G, Ding J, Sun Z, Zhong Y, Song Y, Li Y, Song Z
Veterinary research 2026 Mar 2;57(1)
Veterinary research 2026 Mar 2;57(1)
SARS-CoV-2 spike protein induces depressive-like behaviors by disrupting astrocytic Cx43-mediated gap junction intercellular communication.
Yuan RL, Wang SS, Li PY, Ruan Y, He JQ, Zhou R, Wang WF, Jiang YT, Ye JR, Peng Y, He WB, Chu SF, Zhang Z, Chen NH
Brain, behavior, and immunity 2026 Jan;131:106176
Brain, behavior, and immunity 2026 Jan;131:106176
Recurrent severe viral infection in a child with inherited complete TBK1 deficiency.
Kilic SS, Zhao S, Liu Z, Karali Y, Yalcin K, Bodansky A, Chakravarty D, Wilson M, Casanova JL, Zhang SY
Journal of human immunity 2026 Jan 5;2(1):e20250058
Journal of human immunity 2026 Jan 5;2(1):e20250058
CDK10 suppresses nucleic acid sensors-mediated antitumor immunity.
Xu G, Guo F, He C, Wang X, Xiang B, Fan L, Chen B, Peng J, Sun Y, Shi J, Xing X, Yao Y, Dai P, Li H, Xiong W, Liu H, Xiao R, Qing G, Jiang C, Jiang B, Lei X, Zhang J
Nature cancer 2026 Feb;7(2):283-303
Nature cancer 2026 Feb;7(2):283-303
Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway.
Liu X, Li C, Yang J, Zhang W, Hu Z, Zhang X, Jianati R, Tian F, Dai X, Xu Z, Chen B, Zhu X
Immunity, inflammation and disease 2026 Feb;14(2):e70318
Immunity, inflammation and disease 2026 Feb;14(2):e70318
Single-cell sequencing-guided design of synergistic chemo-immunotherapy nanodrugs for cGAS-STING activation in prostate cancer therapy.
Jiang Y, Zhang Y, Hou J, Liu H, Dai X, Hou Y
Journal of nanobiotechnology 2026 Feb 1;24(1)
Journal of nanobiotechnology 2026 Feb 1;24(1)
Ultrasound-triggered carrier-free nanoprodrugs activate cGAS-STING pathway to enhance tumor-targeting chemo-immunotherapy.
Xu X, Jin P, Chen Y, Wu B, Fang X, Song Y, Luo J, Wang G, Huang P
Materials today. Bio 2026 Apr;37:102858
Materials today. Bio 2026 Apr;37:102858
HDAC7 knockout mitigates astrocyte reactivity and neuroinflammation via the IRF3/cGAS/STING signaling pathway.
Yue RZ, Guo X, Li W, Li C, Shan L
Frontiers in cellular neuroscience 2025;19:1683595
Frontiers in cellular neuroscience 2025;19:1683595
The role and mechanism of the cGAS-STING pathway-mediated ROS in apoptosis and ferroptosis induced by manganese exposure.
Zhang Z, Yang J, Zhou Q, Zhong S, Luo J, Chai X, Liu J, Zhang X, Chang X, Wang H
Redox biology 2025 Sep;85:103761
Redox biology 2025 Sep;85:103761
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription.
Cai Y, Zheng J, Zhao L, Wang X, Zhang L, Wang J, Zhang Y, Shi R, Han J, Han W, Chen W
Nature immunology 2025 Sep;26(9):1581-1595
Nature immunology 2025 Sep;26(9):1581-1595
African swine fever virus pMGF505-9R enhances RIG-I-like receptor signaling by promoting RING finger protein 125 autoubiquitination.
Zhao J, Zhang X, Mou C, Shi K, Chen Z
The Journal of biological chemistry 2025 Oct;301(10):110669
The Journal of biological chemistry 2025 Oct;301(10):110669
GALNT6 dual regulates innate immunity STING signaling and PD-L1 expression to promote immune evasion in pancreatic ductal adenocarcinoma.
Chong S, Liu Y, Bian Z, Hu D, Guo S, Dong C, Zeng J, Fan S, Chen X
Cellular signalling 2025 Oct;134:111942
Cellular signalling 2025 Oct;134:111942
Sclareol can effectively ameliorate Feline calicivirus induced lung injury via the inhibition of inflammation and apoptosis.
Yan Y, Yang M, Liu Z, Li L, Fu Z, Jiao Y, Li M, Li Y, Yao H, Shen Z, Peng G
International immunopharmacology 2025 Oct 30;164:115342
International immunopharmacology 2025 Oct 30;164:115342
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation.
Wang Z, Hou Y, Liu P, Wu R, Yang J, Fan S, Peng Z, Han X, Su B, Zhang C
Immunity 2025 Nov 11;58(11):2670-2684.e10
Immunity 2025 Nov 11;58(11):2670-2684.e10
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery.
Hu K, Ye J, Fan P, Zheng R, Wang S, Peng Y, Ruan Y, Yan X, Zhang Z, Chu S, Chen N
Bioactive materials 2025 May;47:181-197
Bioactive materials 2025 May;47:181-197
The activation of cGAS-STING pathway promotes the epithelial-mesenchymal transition and inflammation in intrauterine adhesion.
Wu X, He L, Lin Y, Zheng Y, Mao R, Hu J, Yuan R, Ge H
International immunopharmacology 2025 Jun 26;159:114840
International immunopharmacology 2025 Jun 26;159:114840
SADS-CoV nsp5 Inhibits Interferon Production by Targeting Kinase IKKε.
She G, Zhong C, Pan Y, Chen Z, Li J, Li M, Liu Y, Cao Y, Wei X, Xue C
Microorganisms 2025 Jun 26;13(7)
Microorganisms 2025 Jun 26;13(7)
Endogenous nanoplatforms for tumor photoimmunotherapy: Hypoxia modulation and STING pathway activation.
Yang Y, Shao N, Luo Q, Cheng N, Chen J, Huang Y, Huang C, Ouyang J, Luo L, Xiao Z
Acta biomaterialia 2025 Jun 1;199:398-411
Acta biomaterialia 2025 Jun 1;199:398-411
Nanodrug Modulates Premetastatic Niche and Suppresses Metastatic Lung Adenocarcinoma via Programmed Cell Death Ligand 1 Blockade and STING Pathway Activation.
Wu X, Li B, Liao H, Chen X, Yu X, Hu J, Lin Q, Cao T, Xu K, Zhou Q, Zhu L
ACS nano 2025 Jul 8;19(26):23893-23907
ACS nano 2025 Jul 8;19(26):23893-23907
Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects.
Wang Z, Liu J, Mou Y, Zhou X, Liao W, Li Y, Liu Y, Tang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156904
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156904
XBP1 promotes endometrial fibrosis through cGAS-STING signaling pathway in intrauterine adhesion.
Wu X, He L, Lin Y, Zheng Y, Jiang P, Tian C, Mao R, Yang B, Shi Y, Ge H, Hu J, Yuan R
Scientific reports 2025 Jul 2;15(1):23299
Scientific reports 2025 Jul 2;15(1):23299
Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse.
Cheng SY, Yang YF, Wang YL, Yue ZP, Chen YZ, Wang WK, Xu ZR, Li LF, Shen H, Qi ZM, Xu CL, Liu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115201
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115201
CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine.
Fan PL, Lai HQ, Wang HY, Hu KC, Ruan Y, Ye JR, Wang SS, Peng Y, He WB, Li G, Yan X, Chu SF, Zhang Z, Chen NH
Cell death and differentiation 2025 Aug;32(8):1499-1517
Cell death and differentiation 2025 Aug;32(8):1499-1517
CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer.
Cai Z, Cheng Z, Zhang L, Zhang Y, Shi J, Jin J, Mi Z, Yuan Z, Wu Z
Cell death & disease 2025 Aug 23;16(1):641
Cell death & disease 2025 Aug 23;16(1):641
An Immune Subtype Classification System Enables the Development of Strategies to Predict and Enhance Immunotherapy Responses in Colorectal Cancer.
Li D, Liu X, Gao W, Zhao W, Ji S, Wang S, Yang J, Li D, Chang Z, Chen Y, Sun X, Zhou J, Jiao Y, Du X, Dong G
Cancer research 2025 Apr 15;85(8):1441-1458
Cancer research 2025 Apr 15;85(8):1441-1458
Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.
Zhou Y, Li H, Zhang Y, Zhao E, Huang C, Pan X, Shu F, Liu Z, Tang N, Li F, Liao W
Cancer letters 2024 May 1;589:216836
Cancer letters 2024 May 1;589:216836
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S, Zhang Z, Chen N
Autophagy 2024 Mar;20(3):590-613
Autophagy 2024 Mar;20(3):590-613
IDI1 inhibits the cGAS-Sting signaling pathway in hepatocellular carcinoma.
Fu L, Ding H, Bai Y, Cheng L, Hu S, Guo Q
Heliyon 2024 Mar 15;10(5):e27205
Heliyon 2024 Mar 15;10(5):e27205
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Li D, Mo R, Li X, Cheng R, Xie J, Li H, Yang Y, Li S, Li H, Yan Z, Wei S, Idris A, Li X, Feng R
mSphere 2024 Jun 25;9(6):e0023624
mSphere 2024 Jun 25;9(6):e0023624
Anemoside B4 inhibits SARS-CoV-2 replication in vitro and in vivo.
Xiao M, Luo R, Liang Q, Jiang H, Liu Y, Xu G, Gao H, Zheng Y, Xu Q, Yang S
Chinese herbal medicines 2024 Jan;16(1):106-112
Chinese herbal medicines 2024 Jan;16(1):106-112
Targeting TRAF6/IRF3 axis to inhibit NF-κB-p65 nuclear translocation enhances the chemosensitivity of 5-FU and reverses the proliferation of gastric cancer.
Chen S, Zhang D, Du Y, Shi J, Gu S, Zhou X, Yu H, Wang F, Chen J, Cui H
Cell death & disease 2024 Dec 20;15(12):924
Cell death & disease 2024 Dec 20;15(12):924
SADS-CoV nsp1 inhibits the IFN-β production by preventing TBK1 phosphorylation and inducing CBP degradation.
Xiang Y, Mou C, Shi K, Chen X, Meng X, Bao W, Chen Z
Journal of medical virology 2023 Sep;95(9):e29104
Journal of medical virology 2023 Sep;95(9):e29104
Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis.
Bierwagen J, Wiegand M, Laakmann K, Danov O, Limburg H, Herbel SM, Heimerl T, Dorna J, Jonigk D, Preußer C, Bertrams W, Braun A, Sewald K, Schulte LN, Bauer S, Pogge von Strandmann E, Böttcher-Friebertshäuser E, Schmeck B, Jung AL
Cell communication and signaling : CCS 2023 Mar 28;21(1):65
Cell communication and signaling : CCS 2023 Mar 28;21(1):65
Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis.
Luo J, Lu C, Chen Y, Wu X, Zhu C, Cui W, Yu S, Li N, Pan Y, Zhao W, Yang Q, Yang X
Cell reports 2023 Apr 25;42(4):112328
Cell reports 2023 Apr 25;42(4):112328
DDX56 antagonizes IFN-β production to enhance EMCV replication by inhibiting IRF3 nuclear translocation.
Xu S, Xie J, Zhang X, Chen L, Bi Y, Li X, Idris A, Feng R
Veterinary microbiology 2022 Jan;264:109304
Veterinary microbiology 2022 Jan;264:109304
MIR155HG Plays a Bivalent Role in Regulating Innate Antiviral Immunity by Encoding Long Noncoding RNA-155 and microRNA-155-5p.
Rai KR, Liao Y, Cai M, Qiu H, Wen F, Peng M, Wang S, Liu S, Guo G, Chi X, Maarouf M, Chen Y, Huang S, Chen JL
mBio 2022 Dec 20;13(6):e0251022
mBio 2022 Dec 20;13(6):e0251022
Swine Acute Diarrhea Syndrome Coronavirus Nucleocapsid Protein Antagonizes Interferon-β Production via Blocking the Interaction Between TRAF3 and TBK1.
Zhou Z, Sun Y, Xu J, Tang X, Zhou L, Li Q, Lan T, Ma J
Frontiers in immunology 2021;12:573078
Frontiers in immunology 2021;12:573078
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