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- Product number
- 10663-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10663-1-AP, RRID:AB_2123636
- Product name
- IL-18 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IL-18 antibody (Cat. #10663-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Tetrastigma hemsleyanum Diels et Gilg Flavonoids Against Acute Lung Injury Via Block NLRP3 Inflammation.
Identifying pyroptosis-related lncRNAs to predict prognosis and immune regulation in hepatocellular carcinoma.
Statins targeting mevalonate-geranylgeranyl diphosphate pathway inhibit proliferation in NK/T lymphoma by promoting pyroptosis.
The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.
Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.
Hungatella hathewayi: A Tumor-Derived Bacterium Enriched in Colorectal Cancer Tissues and a Potential Diagnostic Biomarker.
High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison.
PCSK9 Inhibitor Alirocumab Improves Diabetic Cardiomyopathy Through the ERK/p38 MAPK Signaling Pathway.
Qiming granules regulate Müller cell pyroptosis and the P2X7R/NLRP3 immune inflammatory pathway in diabetic retinopathy.
The role of apolipoprotein C1 in mediating pyroptosis in Hashimoto's thyroiditis via TLR10/MyD88/NF-κB pathway.
Rhubarb ameliorates ischemic stroke-induced tryptophan-kynurenine metabolic reprogramming and neuroinflammation via modulation of the IDO-1/TREM-1 pathway.
Follicular cytokine profiles and granulosa cell integrity across ovarian response during in vitro fertilisation.
Acacetin Alleviates Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease in Mice by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis.
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis.
Qingqi Liangying formula inhibits brain endothelial cell pyroptosis via NLRP3/caspase-1/GSDMD in sepsis-associated encephalopathy.
RRx-001 ameliorates astrocyte pyroptosis by regulating LCN2-NLRP3 inflammasome activation in an MPTP-induced parkinson's disease mouse model.
Recombinant SARS-Cov-2 spike protein S1 subunit upregulates P2 × 7-NLRP3 leading to macrophage pyroptosis promoting acute lung injury.
Size-dependent pyroptosis induction by calcium oxalate monohydrate crystals in HK-2 cells.
HDAC3 Mediates Hippocampal Microglial Pyroptosis Via the STING/NLRP3 Pathway and Contributes To Cognitive Impairment in Sepsis-Associated Encephalopathy.
Empagliflozin alleviates lipid deposition and inflammation in diabetic kidney disease by downregulating C1QC.
A novel lncRNA, lncMCL1, modulates neural pyroptosis associated with epilepsy via stabilizing DDX3X.
Protopine attenuates hepatic fibrosis via HDAC6-mediated NLRP3 inflammasome activation.
CUEDC2 improves pyroptosis and kidney damage in diabetic kidney disease by inhibiting NLRP3 inflammasome activation.
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
Macrophage pyroptosis inhibition alleviates postinjury neointimal formation and vascular restenosis.
Intranasal dantrolene nanoparticles inhibit lipopolysaccharide-induced depression and anxiety behavior in mice.
The regulation of lymphatic valve formation promotes lymphatic drainage to reduce atherosclerotic plaques: A novel mechanism of anti-atherosclerosis by Gualou-Xiebai.
Fruit-Derived Citri Reticulatae Semen Extract Attenuates Alzheimer's Disease Neuroinflammation and Cognitive Impairment via Modulation of the PI3K/Akt/FoxO1 Pathway.
Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling.
Emodin modulates the NLRP3/GSDMD pathway to alleviate Fusobacterium necrophorum-induced pyroptosis in the interdigital skin fibroblasts of dairy Cows.
A multi-omics investigation of Zuojin Wan in alleviating ulcerative colitis: Involvement of gut microbiota, SCFAs, and serum metabolites.
Ginsenoside Rg2 ameliorates acute cold exposure/rewarming-induced myocardial injury via modulating HMGB1/TLR4/NF-κB and PGC-1α signaling pathways: Role of SIRT1.
ADAMTS7 selective inhibitor BAY-9835 alleviates acute myocardial infarction by suppressing the NF-κB-mediated pyroptosis.
Proteomic profiling of the prefrontal cortex reveals Dysregulated Mitochondria-Metabolism-Synapse axis in a chronic Stress-Induced mouse model of depression.
Resveratrol improves follicular development in PCOS rats by inhibiting the inflammatory response and pyroptosis of granulosa cells†.
HIV-HPV interactions via extracellular vesicles among tobacco smokers and nonsmokers.
NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity.
G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage.
Astragaloside IV combined with quercetin attenuates silica-induced pulmonary fibrosis by promoting autophagy and suppressing pyroptosis.
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
The effect of nuciferine on the renal dysfunction following ischemia-reperfusion injury.
The role and mechanism of irisin/NLRP3 signal in aerobic exercise ameliorating blood glucose homeostasis in pre-diabetic mice.
Identification of Pyroptosis-Related Genes in Male Rats with Spared Nerve Injury-Induced Neuropathic Pain.
Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice.
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism.
Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation.
Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway.
Proteus mirabilis exacerbates ulcerative colitis by inhibiting mucin production.
Yersiniabactin produced by Escherichia coli promotes intestinal inflammation through lipid peroxidation and ferroptosis.
Olfactory mucosal mesenchymal stem cells delivered by gelatin sponge scaffolds promote functional recovery of spinal cord injury.
Tangzhiqing Exacerbates Oxidized Low-Density Lipoprotein-Induced Cell Pyroptosis Through Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells.
The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication.
Impact of NLRP6 inflammasome on neuroinflammation in temporal lobe epilepsy.
Curcumin suppresses NLRP3 inflammasome activation by inducing autophagy to alleviate neuropathic pain in rats.
Methamphetamine and HIV-1 Tat Synergistically Induce Microglial Pyroptosis Via Activation of the AIM2 Inflammasome.
Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.
Resveratrol glycoside inhibits NLRP3/IL-1β/NF-κB to alleviate peritoneal fibrosis in peritoneal dialysis.
Rottlerin inhibits PKCδ to attenuate pulmonary fibrosis by suppressing NLRC4/ASC-mediated pyroptosis.
Targeting RelA/NLRP3/CCL3 axis mitigates microglia inflammatory response and promotes recovery after spinal cord injury.
Yogurt alleviates alcohol-induced hepatocyte pyroptosis and inflammation via autophagy/P62/Nrf2/ROS/NLRP3 pathway.
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Wuhu decoction regulates ROS/AMPK/mTOR pathway-mediated dendritic cells autophagy and pyroptosis for the treatment of respiratory syncytial virus-induced asthma.
1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons.
Arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, improved kidney and pancreatic injury in vitro and in vivo in type 2 diabetes mellitus.
Auranofin Ameliorates Gouty Inflammation by Suppressing NLRP3 Activation and Neutrophil Migration via the IL-33/ST2-CXCL1 Axis.
OPA1 modulates NLRP3 inflammasome activation and microglial-mediated neuroinflammation in neonatal hypoxic-ischemic brain injury.
TREM-1 Promotes Microglial Pyroptosis and Mitochondrial Fission in Intracerebral Hemorrhage via the PI3K/AKT Pathway.
MicroRNA-29a attenuates inflammation and fibrosis in an animal model of NASH through MCJ inhibition and hippo pathway regulation.
The role of Lactobacillus rhamnosus in improving estrogen deficiency-induced osteoporosis by inhibiting NLRP3 inflammasome activation.
Corilagin alleviates radiation enteritis through caspase-1/gasdermin D-dependent pyroptosis by targeting aldo-keto reductase family 1 member C2 via glutathione metabolism.
A novel GPR84 antagonist attenuates diabetic lung injury by inhibiting pyroptosis via the cGAS-STING pathway in pulmonary vascular endothelial cells.
Saccharomyces boulardii Alleviates Ovalbumin-Induced Pyroptosis Through Cyba and IL-17 Signaling Pathway.
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Tetramethylpyrazine protects against myocardial ischemia/reperfusion injury via regulating Myl2-mediated NLRP3 signaling pathway inhibition.
Cisplatin transported by COX17 induces cochlear damage by binding Myosin IIA to regulate cell pyroptosis induced by mitochondrial dysfunction.
Electroacupuncture pretreatment alleviates cerebral Ischemia-Reperfusion-Induced intestinal barrier injury and neuroinflammation via inhibition of the TLR4/NLRP3 inflammasome pathway in rats.
Early Potentially Irreversible Cardiac Damage in Fabry Disease Precedes Gb3 Inclusion Body Formation.
Gastrodin Ameliorates Tau Pathology and BBB Dysfunction in 3xTg-AD Transgenic Mice by Regulating the ADRA1/NF-κB/NLRP3 Pathway to Reduce Neuroinflammation.
Protein glycopatterns for natural regulation of microbiota in lung adenocarcinoma.
IL-33 facilitates endoplasmic reticulum stress and pyroptosis in LPS-stimulated ARDS model in vitro.
Hippocampal NLRP1 inflammasome mediates anxiety-like behavior in mice with hypothyroidism.
rhaFGF promotes acute diabetic wound healing by suppressing chronicity of inflammation.
Hyperandrogenism triggers mtDNA release to participate in ovarian inflammation via mPTP/cGAS/STING in PCOS.
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.
E. coli Nissle 1917 improves gut microbiota composition and serum metabolites to counteract atherosclerosis via the homocitrulline/Caspase 1/NLRP3/GSDMD axis.
WISP1 promotes the progression of rheumatoid arthritis through NLRP3 inflammasome activation.
Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.
The novel GSDMD inhibitor GI-Y2 exerts antipyroptotic effects to reduce atherosclerosis.
Oxaliplatin induces pyroptosis in hepatoma cells and enhances antitumor immunity against hepatocellular carcinoma.
Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complex.
Melatonin refines ovarian mitochondrial dysfunction in PCOS by regulating the circadian rhythm gene Clock.
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p.
Sodium butyrate alleviates spinal cord injury via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis.
Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the Brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD Mice.
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Effects of electroacupuncture on neural function and the expression of inflammation-related proteins NLRP3/caspase-1 in rats with ischemic stroke.
Transcranial magnetic stimulation through attenuating blood-spinal cord barrier disruption and reducing inflammatory response to improve motor function in rats with spinal cord injury.
PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.
Shengjiang powder ameliorates cell pyroptosis and inflammation induced by MCAO in rats through the NLRP3/Caspase-1 pathway.
Exploration of the Potential Bioactive Compounds and Functional Mechanism of Chaihu Sanshen Capsule in Ameliorating Myocardial Ischaemia-Reperfusion Injury: A Serum Pharmaco-Chemistry With Network Pharmacology Analysis.
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models.
Hyperandrogenism-mediated YAP activation drives ovarian inflammation and pyroptosis in PCOS: implications for follicular dysfunction.
Rosmarinic Acid Ameliorates Type 2 Diabetic Osteoporosis by Reducing NLRP3 Expression and Alleviating Osteoblast Pyroptosis via the FOXO1/TXNIP Signaling Pathway.
High-Fat Diet-Induced Diabetic Cardiomyopathy in Female Zebrafish: Cardiac Pathology and Functional Decline Mediated by Type 2 Diabetes.
Downregulation of cardiac inflammation via the CaMKII δ/NF-κB pathway in heart failure by Lonicerae Japonicae Flos and Angelicae Sinensis Radix.
Proanthocyanidins alleviate acute alcohol liver injury by inhibiting pyroptosis via inhibiting the ROS-MLKL-CTSB-NLRP3 pathway.
CircFndc3b Mediates Exercise-Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice.
The aqueous extract of Armadillidium vulgare Latreille alleviates neuropathic pain via inhibiting neuron-astrocyte crosstalk mediated by the IL-12-IFN-γ-IFNGR-CXCL10 pathway.
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation.
Tangzu granule alleviate neuroinflammation in diabetic peripheral neuropathy by suppressing pyroptosis through P2X7R /NLRP3 signaling pathway.
Therapeutic effects of tripterygium glycosides on periodontitis: Exploring the role of ursolic acid and the RIPK3/NLRP3 signaling pathway.
The injury effect of osteopontin in sepsis-associated lung injury.
Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway.
Ganoderic Acid A Alleviates Severe Acute Pancreatitis by Modulating Gut Homeostasis and Inhibiting TLR4-NLRP3 Signaling.
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
Inhibition of tumor necrosis factor receptor-associated factor 6 alleviates secondary brain injury by reducing neuronal pyroptosis after intracerebral hemorrhage.
Puerarin reduces diabetic nephropathy-induced podocyte pyroptosis by modulating the SIRT1/NLRP3/caspase-1 pathway.
NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.
Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis.
Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the AMPK/SIRT1 Signaling Pathway.
Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway.
Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse.
FlaA N/C attenuates radiation-induced lung injury by promoting NAIP/NLRC4/ASC inflammasome autophagy and inhibiting pyroptosis.
Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation.
Targeting the NLRP3 in macrophages contributes to senescence cell clearance in radiation-induced skin injury.
Lipotoxicity-induced upregulation of FIS1 exacerbates mitochondrial fragmentation and promotes NLRP3-dependent pyroptosis in diabetic cardiomyopathy.
Analysis of ferroptosis-related genes in cerebral ischemic stroke via immune infiltration and single-cell RNA-sequencing.
Iodine activates NLRP3 inflammasomes in PBMCs of patients with autoimmune thyroiditis and regulates Th1 and Th17 cell differentiation.
Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Brevilin A reverses colitis of inflammatory bowel disease via modulation of TNF-α signaling and microbiome dysregulation.
Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Eukaryotic ADCY7 catalyzes the production of c-di-AMP to activate the NLRP3 inflammasome.
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult.
Microglia specific Csf1r haploinsufficiency induces depressive-like behaviors by promoting NLRP6/caspase-1 signaling in mice.
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy.
Vitamin D improves diabetic cardiomyopathy by inhibiting pyroptosis through the NOX4/NLRP3 inflammasome pathway.
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood-Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation.
Schistosoma mansoni soluble egg antigen suppresses colorectal cancer growth in vitro and in vivo.
CEBPA as a potential hub gene for cutaneous inflammation in type 2 diabetes mellitus.
Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity.
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes.
Chrysophanol Attenuates Cardiac Fibrosis and Arrhythmia by Suppressing the Endoplasmic Reticulum Stress/Pyroptosis Axis and Inflammation.
Salvianolic acid B (SalB) improves high-fat diet (HFD)-caused cognitive impairment in mice by modulating the Trem2/Dap12 pathway in vivo and in vitro.
Kanglexin attenuates spinal cord injury by modulating pyroptosis and polarization via the PKA/NF-κB signaling pathway.
OAB-14 Attenuated Glymphatic System Disorder, Neuroinflammation and Dyskinesia in Parkinson's Disease Model Mice Induced by Rotenone.
Extracellular Vesicle-Liposome-Darunavir Formulation for the Treatment of HIV Neuropathogenesis.
Interleukin 1β Mediates the Pathogenesis of Nasal Mucosal Epithelial Barrier Dysfunction in Allergic Rhinitis.
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
The AGEs/RAGE Signaling Pathway Regulates NLRP3-Mediated Neuronal Pyroptosis After MCAO Injury in Lepr(-/-) Obese Rats.
Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway.
Effect of NLRP3 inflammasome induced astrocyte phenotype alteration in morphine tolerance.
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis.
Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation.
GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis.
Microglia and Astrocytes Responses Contribute to Alleviating Inflammatory Damage by Repetitive Transcranial Magnetic Stimulation in Rats with Traumatic Brain Injury.
Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome.
Disulfiram attenuates cell and tissue damage and blood‒brain barrier dysfunction after intracranial haemorrhage by inhibiting the classical pyroptosis pathway.
Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome.
β-Caryophyllene mitigates ischemic stroke-induced white matter lesions by inhibiting pyroptosis.
Targeting Mitochondrial Oxidative Stress to Protect Against Preterm Birth and Fetal Brain Injury via Nrf2 Induction.
Identification of a novel caspase cleavage motif AEAD.
Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to participate in stroke injury and post-stroke anxiety like behavior.
Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α.
IL-18, a therapeutic target for immunotherapy boosting, promotes temozolomide chemoresistance via the PI3K/AKT pathway in glioma.
Anti irradiation nanoparticles shelter immune organ from radio-damage via preventing the IKK/IκB/NF-κB activation.
Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells.
The phosphorylation of Smad3 by CaMKIIγ leads to the hepatocyte pyroptosis under perfluorooctane sulfonate exposure.
Gut microbiome and metabolites mediate the benefits of caloric restriction in mice after acute kidney injury.
HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS-induced acute kidney injury.
GATA1-activated lncRNA OIP5-AS1 and GAS5 promote pyroptosis to exacerbate asthma through regulating miR-136-5p/LIFR axis.
SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway.
Intranasal dantrolene nanoparticles inhibit inflammatory pyroptosis in 5XFAD mice brains.
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis.
Sulfiredoxin 1 ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the Sirt1/NLRP3 pathway.
UCP2 knockout exacerbates sepsis-induced intestinal injury by promoting NLRP3-mediated pyroptosis.
Mechanics-activated fibroblasts promote pulmonary group 2 innate lymphoid cell plasticity propelling silicosis progression.
The role of NLRP3 inflammasome-mediated neuroinflammation in chronic noise-induced impairment of learning and memory ability.
Hexavalent chromium exposure induces lung injury via activation of NLRP3 and AIM2 inflammasomes in rats.
Inhibition of SPARC signal by aerobic exercise to ameliorate atherosclerosis.
α-Ketoglutarate Improves Ovarian Reserve Function in Primary Ovarian Insufficiency by Inhibiting NLRP3-Mediated Pyroptosis of Granulosa Cells.
Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway.
Correlational analysis of PLIN1 with inflammation in diabetic foot ulcer wounds.
Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats.
NRF2 activation ameliorates blood-brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation.
Triclosan induces liver injury in long-life exposed mice via activation of TLR4/NF-κB/NLRP3 pathway.
Cyclin-dependent kinase inhibitor 1A inhibits pyroptosis to enhance human lung adenocarcinoma cell radioresistance by promoting DNA repair.
Taohong Siwu decoction reduces acute myocardial ischemia-reperfusion injury by promoting autophagy to inhibit pyroptosis.
P2Y(13) receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation.
Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation.
Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling.
Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS.
3-MCPD Induces Renal Cell Pyroptosis and Inflammation by Inhibiting ESCRT-III-Mediated Cell Repair and Mitophagy.
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.
Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration.
The antidepressant effect of Shexiang Baoxin Pills on myocardial infarction rats with depression may be achieved through the inhibition of the NLRP3 inflammasome pathway.
Uric acid-lowering effect of harpagoside and its protective effect against hyperuricemia-induced renal injury in mice.
Sestrin2 Restricts Endothelial-to-Mesenchymal Transition Induced by Lipolysaccharide via Autophagy.
Effect and mechanism of T lymphocytes on human induced pluripotent stem cell-derived cardiomyocytes via Proteomics.
EZH2-STAT3 signaling pathway regulates GSDMD-mediated pyroptosis in glioblastoma.
Disulfiram downregulates ferredoxin 1 to maintain copper homeostasis and inhibit inflammation in cerebral ischemia/reperfusion injury.
CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase‑1‑dependent pyroptosis.
A novel stroke rehabilitation strategy and underlying stress granule regulations through inhibition of NLRP3 inflammasome activation.
Empagliflozin alleviates the development of autoimmune myocarditis via inhibiting NF-κB-dependent cardiomyocyte pyroptosis.
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
Yunvjian decoction attenuates lipopolysaccharide-induced periodontitis by suppressing NFκB/NLRP3/IL-1β pathway.
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
The improvement of homocysteine-induced myocardial inflammation by vitamin D depends on activation of NFE2L2 mediated MTHFR.
Rutin prevents pyroptosis and M1 microglia via Nrf2/Mac-1/caspase-1-mediated inflammasome axis to improve POCD.
SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis.
SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus.
Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.
SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.
Demethylase FTO-Mediated m6A Modification of lncRNA MEG3 Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke.
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
L-ascorbyl-2-phosphate alleviates white matter injury caused by chronic hypoxia through the PRMT5/P53/NF-κB pathway.
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice.
ENST00000534735 inhibits proliferation and migration, promotes apoptosis and pyroptosis of endometrial cancer via OSBPL3 through APMK/SIRT1/NF-κB pathway.
Transplantation of olfactory ensheathing cells can alleviate neuroinflammatory responses in rats with trigeminal neuralgia.
CTRP3 inhibits myocardial fibrosis through the P2X7R-NLRP3 inflammasome pathway in SHR rats.
Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation.
Corynoline alleviates hepatic ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling.
An Amino Acids and Dipeptide Injection Inhibits the TNF-α/HMGB1 Inflammatory Signaling Pathway to Reduce Pyroptosis and M1 Microglial Polarization in POCD Mice: the Gut to the Brain.
Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells.
Interleukin-18 interacts with NKCC1 to mediate brain injury after intracerebral hemorrhage.
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
Lipopolysaccharide-regulated RNF31/NRF2 axis in colonic epithelial cells mediates homeostasis of the intestinal barrier in ulcerative colitis.
Outer Membrane Vesicles Derived From Fusobacterium nucleatum Trigger Periodontitis Through Host Overimmunity.
Fucoidan from Laminaria japonica protects renal tubular epithelial cells from uric acid induced NLRP3-mediated pyroptosis through inhibition of NF-κB pathway.
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
SUCNR 1 promotes atherosclerosis by inducing endoplasmic reticulum stress mediated ER-mito crosstalk.
METTL3-mediated m(6)A modification of CD36: Implications for glucose metabolism and inflammatory dysregulation in follicles of polycystic ovary syndrome.
Electroacupuncture extends the time window of thrombolytic therapy in rats by reducing disruptions of blood-brain barrier and inhibiting GSDMD-mediated pyroptosis.
Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD mice.
Sweroside alleviates pressure overload-induced heart failure through targeting CaMKⅡδ to inhibit ROS-mediated NF-κB/NLRP3 in cardiomyocytes.
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease.
A2 reactive astrocyte-derived exosomes alleviate cerebral ischemia-reperfusion injury by delivering miR-628.
Bisphenol S exposure induces intestinal inflammation via altering gut microbiome.
Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis.
Combined bacterial translocation and cholestasis aggravates liver injury by activation pyroptosis in obstructive jaundice.
Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization.
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Matrine Suppresses Arsenic-Induced Malignant Transformation of SV-HUC-1 Cells via NOX2.
Capsaicin alleviates acute alcohol-induced pyroptosis by activating ESCRT-III-dependent cell membrane repair in hepatocytes.
Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.
Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and TXNIP for binding to NLRP3 inflammasome in response to neuroinflammation.
Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy.
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.
Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.
TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway.
Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells.
The GFPT2-O-GlcNAcylation-YBX1 axis promotes IL-18 secretion to regulate the tumor immune microenvironment in pancreatic cancer.
Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes.
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats.
Garlic oil supplementation blocks inflammatory pyroptosis-related acute lung injury by suppressing the NF-κB/NLRP3 signaling pathway via H(2)S generation.
Galangin Prevents Against Ethanol-Induced Intestinal Barrier Dysfunction and NLRP3 Inflammasome Activation via NF-κB/MAPK Signaling Pathways in Mice and Caco-2 Cells.
GroEL triggers NLRP3 inflammasome activation through the TLR/NF-κB p-p65 axis in human periodontal ligament stem cells.
Mechanisms of resveratrol against diabetic wound by network pharmacology and experimental validation.
Histone H3 activates caspase-1 and promotes proliferation and metastasis in hepatocellular carcinoma.
High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis.
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
Single-cell landscape of immune cells during the progression from HBV infection to HBV cirrhosis and HBV-associated hepatocellular carcinoma.
Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation.
The Role of Endophilin A1 in Lipopolysaccharide-Induced Parkinson's Disease Model Mice.
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
STING deletion alleviates podocyte injury through suppressing inflammation by targeting NLRP3 in diabetic kidney disease.
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis.
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis.
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
HMGB1 induces macrophage pyroptosis in chronic endometritis.
Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway.
Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs/NF-kB and pyroptosis pathways.
Cordyceps militaris Solid Medium Extract Alleviates Lipoteichoic Acid-Induced MH-S Inflammation by Inhibiting TLR2/NF-κB/NLRP3 Pathways.
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer.
CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis.
Colchicine protects against the development of experimental abdominal aortic aneurysm.
Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke.
Oxalate‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling in vitro and in vivo.
Elaidic acid induced hepatocyte pyroptosis via autophagy-CTSB-NLRP3 pathway.
Polydatin protects against calcium oxalate crystal-induced renal injury through the cytoplasmic/mitochondrial reactive oxygen species-NLRP3 inflammasome pathway.
The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice.
Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.
Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice.
Homer1 Protects against Retinal Ganglion Cell Pyroptosis by Inhibiting Endoplasmic Reticulum Stress-Associated TXNIP/NLRP3 Inflammasome Activation after Middle Cerebral Artery Occlusion-Induced Retinal Ischemia.
Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro-survival.
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer.
CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.
DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury.
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Achyranthoside D attenuates chondrocyte loss and inflammation in osteoarthritis via targeted regulation of Wnt3a.
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.
The expression of cyclic GMP-AMP synthase in human apical periodontitis: A laboratory investigation.
Salmonella typhimurium exacerbates injuries but resolves fibrosis in liver and spleen during Schistosoma mansoni infection.
LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis.
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy.
Growth differentiation factor 15 protects the airway by inhibiting cell pyroptosis in obese asthmatic mice through the phosphoinositide 3-kinase/AKT pathway.
Combined exposure to lead and high-fat diet induced neuronal deficits in rats: Anti-neuroinflammatory role of SIRT1.
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
RGD1564534 represses NLRP3 inflammasome activity in cerebral injury following ischemia-reperfusion by impairing miR-101a-3p-mediated Dusp1 inhibition.
Alternate-day fasting for the protection of cognitive impairment in c57BL/6J mice following whole-brain radiotherapy.
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation.
Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats.
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223-3p/NLRP3 axis.
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Astragaloside IV ameliorate acute alcohol-induced liver injury in mice via modulating gut microbiota and regulating NLRP3/caspase-1 signaling pathway.
Regulating NLRP3 Inflammasome-Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
The E3 ubiquitin ligase RNF31 mediates the development of ulcerative colitis by regulating NLRP3 inflammasome activation.
Yi-Qi-Jian-Pi formula inhibits hepatocyte pyroptosis through the IDH2-driven tricarboxylic acid cycle to reduce liver injury in acute-on-chronic liver failure.
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
The Comparative Effects of Schwann Cells and Wharton's Jelly Mesenchymal Stem Cells on the AIM2 Inflammasome Activity in an Experimental Model of Spinal Cord Injury.
The role of ROS-pyroptosis in PM(2.5) induced air-blood barrier destruction.
A novel long noncoding RNA-lncRNA-AABR07066529.3 alleviates inflammation, apoptosis, and pyroptosis by inhibiting MyD88 in lipopolysaccharide-induced myocardial depression.
Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2.
Effects of sodium metabisulfite on pyroptosis, mitophagy and degranulation in mast cells.
Sodium houttuyfonate plays a protective role in the asthmatic airway by alleviating the NLRP3-related pyroptosis and Th1/Th2 immune imbalance.
Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model.
Transcriptomics Reveals Molecular Features of the Bilateral Pelvic Nerve Injury Rat Model of Detrusor Underactivity.
Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R(-/-)mice.
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
Melatonin inhibits atherosclerosis progression via galectin-3 downregulation to enhance autophagy and inhibit inflammation.
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B.
lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.
Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy.
Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease.
Sodium Tanshinone IIA Sulfonate Inhibits Vascular Endothelial Cell Pyroptosis via the AMPK Signaling Pathway in Atherosclerosis.
P2X7R-NEK7-NLRP3 Inflammasome Activation: A Novel Therapeutic Pathway of Qishen Granule in the Treatment of Acute Myocardial Ischemia.
Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway.
Qingchang Wenzhong Decoction Prevents the Occurrence of Intestinal Tumors by Regulating Intestinal Microbiota and Gasdermin E.
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro.
Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway.
(-)-Epicatechin Ameliorates Monosodium Urate-Induced Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and the NF-κB Signaling Pathway.
Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p.
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.
Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome.
Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade.
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE.
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats.
linc00174 deteriorates the pathogenesis of diabetic retinopathy via miR-26a-5p/PTEN/Akt signalling cascade-mediated pyroptosis.
LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.
Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway.
Apigenin alleviated PA-induced pyroptosis by activating autophagy in hepatocytes.
Esculetin inhibits the pyroptosis of microvascular endothelial cells through NF-κB /NLRP3 signaling pathway.
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.
Platonin protects against cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasomes via BNIP3/LC3 signaling mediated autophagy.
Qishen granule (QSG) exerts cardioprotective effects by inhibiting NLRP3 inflammasome and pyroptosis in myocardial infarction rats.
Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.
α(1) -Adrenoceptors activate the NLRP3 inflammasome through downregulation of Kir2.1 in cardiac inflammation.
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells.
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway.
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Alliin alleviates LPS-induced pyroptosis via promoting mitophagy in THP-1 macrophages and mice.
IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence.
Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway.
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Protective Effect and Mechanism of Melatonin on Cisplatin-Induced Ovarian Damage in Mice.
Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome.
Use of wogonin as a cooperative drug with praziquantel to better combat schistosomiasis.
Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.
miR-142a-3p Enhances FlaA N/C Protection Against Radiation-Mediated Intestinal Injury by Modulating the IRAK1/NF-κB Signaling Pathway.
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney.
General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease.
Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis.
Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Ibudilast Attenuates Folic Acid-Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-κB and MAPK Signaling Pathways.
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS.
PRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma.
Ameliorative effects of miR-423-5p against polarization of microglial cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway.
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients.
6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy.
The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest.
Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.
c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway.
Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis.
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
SET8 mitigates hepatic ischemia/reperfusion injury in mice by suppressing MARK4/NLRP3 inflammasome pathway.
Naringenin prevents TNF-α-induced gut-vascular barrier disruption associated with inhibiting the NF-κB-mediated MLCK/p-MLC and NLRP3 pathways.
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
FUNDC1 inhibits NLRP3-mediated inflammation after intracerebral hemorrhage by promoting mitophagy in mice.
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Sodium Sulfite-Induced Mast Cell Pyroptosis and Degranulation.
Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway.
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy.
Inflammasome components and ADAMTS4 in premature rupture of membranes.
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
An In-vivo Study into the Effects of Schisandrin B in the Liver, Spleen, Kidney, and Brain of Acute Thioacetamide-intoxicated Mice.
Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation.
Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway.
Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production.
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R(-/-)) Mice via Its Anti-inflammatory and Antipyroptotic Effects.
Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia.
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
NLRP6 contributes to inflammation and brain injury following intracerebral haemorrhage by activating autophagy.
FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity.
Telomere dysfunction activates YAP1 to drive tissue inflammation.
H3 relaxin protects against calcium oxalate crystal-induced renal inflammatory pyroptosis.
Ibuprofen Exerts Antiepileptic and Neuroprotective Effects in the Rat Model of Pentylenetetrazol-Induced Epilepsy via the COX-2/NLRP3/IL-18 Pathway.
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Impact of chitosan membrane culture on the expression of pro- and anti-inflammatory cytokines in mesenchymal stem cells.
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.
Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.
Autophagy Activation Represses Pyroptosis through the IL-13 and JAK1/STAT1 Pathways in a Mouse Model of Moderate Traumatic Brain Injury.
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice.
Histone Deacetylation 10 Alleviates Inflammation After Intracerebral Hemorrhage via the PTPN22/NLRP3 Pathway in Rats.
Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release.
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic E. coli infection.
Ameliorative effects of echinacoside against spinal cord injury via inhibiting NLRP3 inflammasome signaling pathway.
Light-emitting diode therapy protects against ventricular arrhythmias by neuro-immune modulation in myocardial ischemia and reperfusion rat model.
Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells.
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis.
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
Clostridium butyricum regulates visceral hypersensitivity of irritable bowel syndrome by inhibiting colonic mucous low grade inflammation through its action on NLRP6.
Increased expression of NLRP3 inflammasome components and interleukin-18 in patients with bullous pemphigoid.
NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins.
Schistosoma japonicum scFv-IL18 fusion DNA ameliorates hepatic fibrosis in schistosomiasis-infected mice via improving local concentration of IL-18 in liver.
Zhan L, Li L, Wu X, Jiang X, Zhou J, Zhu S, Shu C, Pu J, Liang W
Mediators of inflammation 2026;2026:2279402
Mediators of inflammation 2026;2026:2279402
Identifying pyroptosis-related lncRNAs to predict prognosis and immune regulation in hepatocellular carcinoma.
Zhang W, Wang Y, Meng Q, Liu Z, Qu S, Zhou J
Frontiers in molecular biosciences 2026;13:1714966
Frontiers in molecular biosciences 2026;13:1714966
Statins targeting mevalonate-geranylgeranyl diphosphate pathway inhibit proliferation in NK/T lymphoma by promoting pyroptosis.
Wang Y, Mei M, Wang J, Wei L, Zhang M, Zhang M
Translational oncology 2026 May;67:102747
Translational oncology 2026 May;67:102747
The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.
Li W, Zhou D, Ji Y, Yang M, Yang Y, Dao M, He X, Jin X
International journal of cardiology. Cardiovascular risk and prevention 2026 Mar;28:200562
International journal of cardiology. Cardiovascular risk and prevention 2026 Mar;28:200562
Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.
Zhang M, Wang B, Sun D, Chen X, Zhou Y, Yao J, Du L, Zhang Z, Li H, Qu Z, Chen L, Luo Q, Zhang J, Jin X, Cheng X, Niu J, Xing Q, Tan X, Wang T, Liu J, Li L, Song Q, Chen X, Chen Y
JCI insight 2026 Mar 23;11(6)
JCI insight 2026 Mar 23;11(6)
Hungatella hathewayi: A Tumor-Derived Bacterium Enriched in Colorectal Cancer Tissues and a Potential Diagnostic Biomarker.
Zhang W, Liu J, Sha S, Yan Q, Ma Y
Microorganisms 2026 Mar 21;14(3)
Microorganisms 2026 Mar 21;14(3)
High-Intensity Interval Training Outperforms Moderate-Intensity Exercise in Hyperlipidemic ApoE⁻/⁻ Mice: A Molecular and Histological Comparison.
Qian C, Pei Z, Yang Z, Sun M, Zhang Y, Liu H, Sun Y
Frontiers in bioscience (Landmark edition) 2026 Mar 20;31(3):47751
Frontiers in bioscience (Landmark edition) 2026 Mar 20;31(3):47751
PCSK9 Inhibitor Alirocumab Improves Diabetic Cardiomyopathy Through the ERK/p38 MAPK Signaling Pathway.
Lin S, Wu B, Sun S, Sun T
International journal of molecular sciences 2026 Mar 2;27(5)
International journal of molecular sciences 2026 Mar 2;27(5)
Qiming granules regulate Müller cell pyroptosis and the P2X7R/NLRP3 immune inflammatory pathway in diabetic retinopathy.
Zhou Q, Tang M, Wang Y, Lv H, Yang G, Wang F, Ye H
Chinese medicine 2026 Mar 16;21(1)
Chinese medicine 2026 Mar 16;21(1)
The role of apolipoprotein C1 in mediating pyroptosis in Hashimoto's thyroiditis via TLR10/MyD88/NF-κB pathway.
Sun B, Tan J, Yu S, Ge J, Wei Z, Lei S, Li G
Molecular immunology 2026 Jun;194:52-62
Molecular immunology 2026 Jun;194:52-62
Rhubarb ameliorates ischemic stroke-induced tryptophan-kynurenine metabolic reprogramming and neuroinflammation via modulation of the IDO-1/TREM-1 pathway.
Liu X, Wang X, Wang Y, Zhu H, Xiang Q, Li Q, Wang X, Xu W, Jiang M, Wang W, Gao J, Wang T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158133
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158133
Follicular cytokine profiles and granulosa cell integrity across ovarian response during in vitro fertilisation.
Korkmaz O, Karabulut S, Macit P
Tissue & cell 2026 Jun;100:103370
Tissue & cell 2026 Jun;100:103370
Acacetin Alleviates Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease in Mice by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis.
Xu X, Liu X, Yao L, Yin X
Applied biochemistry and biotechnology 2026 Jan;198(1):640-654
Applied biochemistry and biotechnology 2026 Jan;198(1):640-654
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis.
Huang K, Xiao JL, Tang JY, Pu HY, Li FH, Gao K, Yu X, Guo SZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157625
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157625
Qingqi Liangying formula inhibits brain endothelial cell pyroptosis via NLRP3/caspase-1/GSDMD in sepsis-associated encephalopathy.
Song S, Ding L, Huang Q, Zhang Z, Cao L, Yin K, Wang Z, Zhao D, Wang Z, Zhao L, Tong X, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157391
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157391
RRx-001 ameliorates astrocyte pyroptosis by regulating LCN2-NLRP3 inflammasome activation in an MPTP-induced parkinson's disease mouse model.
Shu H, Huang X, Su Z, Liang F, Ding L, Luo K, Liu T, Huang W, Xiao Y, Zhang W, Xu P
Cellular and molecular life sciences : CMLS 2026 Jan 7;83(1):60
Cellular and molecular life sciences : CMLS 2026 Jan 7;83(1):60
Recombinant SARS-Cov-2 spike protein S1 subunit upregulates P2 × 7-NLRP3 leading to macrophage pyroptosis promoting acute lung injury.
Lu M, Li M, Zhou H, Zhu J, Jiao Q, Liu X, Wu J, Xu G, Lv C, Fan Y, Zhang B, Pan L
Respiratory research 2026 Jan 23;27(1):76
Respiratory research 2026 Jan 23;27(1):76
Size-dependent pyroptosis induction by calcium oxalate monohydrate crystals in HK-2 cells.
Chen XW, Tong XY, Tan RM, Ouyang JM
iScience 2026 Jan 16;29(1):114459
iScience 2026 Jan 16;29(1):114459
HDAC3 Mediates Hippocampal Microglial Pyroptosis Via the STING/NLRP3 Pathway and Contributes To Cognitive Impairment in Sepsis-Associated Encephalopathy.
Cai M, Shao H, Xu S, Wang H, Yang MJ, Zhu T, Chen J, Li GZ, Lu SF, Zang YY, Ji MH, Shen JC, Jia M, Yang JJ
Inflammation 2026 Jan 10;49(1):39
Inflammation 2026 Jan 10;49(1):39
Empagliflozin alleviates lipid deposition and inflammation in diabetic kidney disease by downregulating C1QC.
Shi S, Li W, Yang L, Zhang J, Wu X
Molecular and cellular biochemistry 2026 Feb;481(2):885-898
Molecular and cellular biochemistry 2026 Feb;481(2):885-898
A novel lncRNA, lncMCL1, modulates neural pyroptosis associated with epilepsy via stabilizing DDX3X.
Wang H, Wu L, Liu C, Zhao X, Cui L, Gao J, Zhang C, Du T, Shi L, Ji Y, Xiao Y, Zhang J, Tu W, Meng F, Han C
Cell death and differentiation 2026 Feb;33(2):374-391
Cell death and differentiation 2026 Feb;33(2):374-391
Protopine attenuates hepatic fibrosis via HDAC6-mediated NLRP3 inflammasome activation.
Li Y, Liang M, Wang X, Zhu Q, Nie J, Sun L
Bioorganic chemistry 2026 Feb;169:109394
Bioorganic chemistry 2026 Feb;169:109394
CUEDC2 improves pyroptosis and kidney damage in diabetic kidney disease by inhibiting NLRP3 inflammasome activation.
Yang P, Fan L, Yuan D, Xie J, Luo Y, Zeng Q, Lin W, Li Z, Huang Z, Jiang W, Wang M, Huang Y
Cellular signalling 2026 Feb;138:112239
Cellular signalling 2026 Feb;138:112239
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
Ma CS, Han B, Guo JR, Guo JF, Shi CK, Liu YX, Yi WJ, Zhang LY, Deng AJ, Wang YS, He MT
Journal of translational medicine 2026 Feb 7;24(1)
Journal of translational medicine 2026 Feb 7;24(1)
Macrophage pyroptosis inhibition alleviates postinjury neointimal formation and vascular restenosis.
Ji Z, He M, Wu H, Chen S, Wang S, Yin X, Wang H
Journal of translational medicine 2026 Feb 3;24(1)
Journal of translational medicine 2026 Feb 3;24(1)
Intranasal dantrolene nanoparticles inhibit lipopolysaccharide-induced depression and anxiety behavior in mice.
Liu J, Lu Y, Bhuiyan P, Gruttner J, St Louis L, Yi Y, Liang G, Wei H
Translational psychiatry 2026 Feb 3;16(1)
Translational psychiatry 2026 Feb 3;16(1)
The regulation of lymphatic valve formation promotes lymphatic drainage to reduce atherosclerotic plaques: A novel mechanism of anti-atherosclerosis by Gualou-Xiebai.
Liu J, Li Z, Sun X, Zhu L, Bao Y, Liu Z, Xu Y, Xia X, Zhao W, Zhang Y, Zhou A, Wu H
Journal of ethnopharmacology 2026 Feb 28;357:120937
Journal of ethnopharmacology 2026 Feb 28;357:120937
Fruit-Derived Citri Reticulatae Semen Extract Attenuates Alzheimer's Disease Neuroinflammation and Cognitive Impairment via Modulation of the PI3K/Akt/FoxO1 Pathway.
Li S, Zhang X, Zhang P, Wang X, Yang Y, Qin D, Law BY, Pan Y, Tang Y
Molecular nutrition & food research 2026 Apr;70(7):e70452
Molecular nutrition & food research 2026 Apr;70(7):e70452
Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling.
Deng Q, Liu Z, Ye Q, Liu J, Fu Z, Zhang X, Luo J, Lu Z, Yue P, Xiao J, Xiao Q
International journal of molecular medicine 2026 Apr;57(4)
International journal of molecular medicine 2026 Apr;57(4)
Emodin modulates the NLRP3/GSDMD pathway to alleviate Fusobacterium necrophorum-induced pyroptosis in the interdigital skin fibroblasts of dairy Cows.
Zhang A, Liu M, Tang Y, Wang R, Ruan H, Zhu T, Ge Y, Xu E, Zheng J
International journal of biological macromolecules 2026 Apr;353:151331
International journal of biological macromolecules 2026 Apr;353:151331
A multi-omics investigation of Zuojin Wan in alleviating ulcerative colitis: Involvement of gut microbiota, SCFAs, and serum metabolites.
Sun H, Yu Z, Piao C, Gu J, Geng F, Ai H, Jiang S, Ren Y, Gao J, Wang Z, Liu J, Zhang N, Xu H
Fitoterapia 2026 Apr;190:107135
Fitoterapia 2026 Apr;190:107135
Ginsenoside Rg2 ameliorates acute cold exposure/rewarming-induced myocardial injury via modulating HMGB1/TLR4/NF-κB and PGC-1α signaling pathways: Role of SIRT1.
Zuo S, Fu W, Ma W, Wang H, Feng S, Sun H, Zhang Z, Li L, Xue Y, Xu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157997
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157997
ADAMTS7 selective inhibitor BAY-9835 alleviates acute myocardial infarction by suppressing the NF-κB-mediated pyroptosis.
Ling Y, Lyu Y, Chen H, Lin B, Zhou G, Chen S, Weng T, Ruan Z, Zhu Y, Zhu Z, Guo Y, Lin K
Toxicology and applied pharmacology 2026 Apr 28;:117836
Toxicology and applied pharmacology 2026 Apr 28;:117836
Proteomic profiling of the prefrontal cortex reveals Dysregulated Mitochondria-Metabolism-Synapse axis in a chronic Stress-Induced mouse model of depression.
Zhang Y, Li L, Zhang X, Xu J, Kan W, Wang T, Du J
Neuroscience letters 2026 Apr 26;877:138569
Neuroscience letters 2026 Apr 26;877:138569
Resveratrol improves follicular development in PCOS rats by inhibiting the inflammatory response and pyroptosis of granulosa cells†.
Wei H, Zhang Z, Zhang S, Wang J, Cui X, Zhang Z, Yu J, Lei X, Xiuhong Z, Huo P
Biology of reproduction 2026 Apr 13;114(4):1227-1240
Biology of reproduction 2026 Apr 13;114(4):1227-1240
HIV-HPV interactions via extracellular vesicles among tobacco smokers and nonsmokers.
Sinha N, Hiser L, Godse S, Zhou L, Shynykul Z, Risley C, Cory T, Kumar S
Experimental biology and medicine (Maywood, N.J.) 2025;250:10687
Experimental biology and medicine (Maywood, N.J.) 2025;250:10687
NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity.
Liu Y, Liu B, Shi M, Ye T, Li H
Mediators of inflammation 2025;2025:4112856
Mediators of inflammation 2025;2025:4112856
G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage.
Peng J, Hu X, He J, Xia Y
Mediators of inflammation 2025;2025:3585885
Mediators of inflammation 2025;2025:3585885
Astragaloside IV combined with quercetin attenuates silica-induced pulmonary fibrosis by promoting autophagy and suppressing pyroptosis.
Zhu W, Zhao N, Ma Y, Zhang W, Ma J, Cao M, Yang Y, Sun S, Pan Z, Shao H, Du Z
PloS one 2025;20(6):e0327255
PloS one 2025;20(6):e0327255
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
Wang Y, Liao Q, Mei X, Xu H, Luo L, Huang R, Tang Y, Zhou C
PloS one 2025;20(6):e0326687
PloS one 2025;20(6):e0326687
The effect of nuciferine on the renal dysfunction following ischemia-reperfusion injury.
Sallabi SM, Lubbad L, Toumi HR, Hammad WF, Sudhadevi M, Rasheed JA, Hammad AF, Ardah MM, Al-Salam S, Hammad FT
PloS one 2025;20(3):e0320320
PloS one 2025;20(3):e0320320
The role and mechanism of irisin/NLRP3 signal in aerobic exercise ameliorating blood glucose homeostasis in pre-diabetic mice.
Hu S, Wu Z, Liu X, Ding Y, Chen J, Wang X
PloS one 2025;20(11):e0336395
PloS one 2025;20(11):e0336395
Identification of Pyroptosis-Related Genes in Male Rats with Spared Nerve Injury-Induced Neuropathic Pain.
Li W, Hu Z, Lin P, He L, Liu R
Journal of pain research 2025;18:7029-7041
Journal of pain research 2025;18:7029-7041
Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice.
Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X
Journal of inflammation research 2025;18:1167-1189
Journal of inflammation research 2025;18:1167-1189
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Kang M, Cai J, Yi W, Zhang B, Ai L, Ning B, Dong J, Chen L, Fu W
American journal of translational research 2025;17(5):3619-3629
American journal of translational research 2025;17(5):3619-3629
Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism.
Lei C, Zhao C, Li X, Wang K, Cen T, Liu Q, Xu X, Zhang J
Frontiers in immunology 2025;16:1709586
Frontiers in immunology 2025;16:1709586
Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation.
Li W, Huang W, Zhou P, Yao Y, Cai B, Ye S
Frontiers in pharmacology 2025;16:1690192
Frontiers in pharmacology 2025;16:1690192
Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway.
Zhou X, Wang Z, Wang Y, Xu G, Luo M, Zhang M, Li Y
Frontiers in pharmacology 2025;16:1590096
Frontiers in pharmacology 2025;16:1590096
Proteus mirabilis exacerbates ulcerative colitis by inhibiting mucin production.
Jiang Z, Li P, Qiu K, Liao Y, Chen X, Xuan J, Wang F, Ma H, Wang Y, Zhu M
Frontiers in microbiology 2025;16:1556953
Frontiers in microbiology 2025;16:1556953
Yersiniabactin produced by Escherichia coli promotes intestinal inflammation through lipid peroxidation and ferroptosis.
Wang H, Chen B, Xiao P, Han D, Gao B, Yan Y, Zhao R, Pan T, Zhang J, Zhou M, Lv L, Gao H
Frontiers in microbiology 2025;16:1542801
Frontiers in microbiology 2025;16:1542801
Olfactory mucosal mesenchymal stem cells delivered by gelatin sponge scaffolds promote functional recovery of spinal cord injury.
Li W, Jiang X, Lu S, Lu W, Ma S, Zhuo Y, Gao Q, Xiao Y, Wu B, Xie J, Yu Y, Li X, Deng Q, Lu M
Frontiers in bioengineering and biotechnology 2025;13:1628758
Frontiers in bioengineering and biotechnology 2025;13:1628758
Tangzhiqing Exacerbates Oxidized Low-Density Lipoprotein-Induced Cell Pyroptosis Through Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells.
Chen R, Zhou Z, Song Z, Feng W, Ding X, Zhang H, Wang Y
Cell biology international 2025 Sep;49(9):1173-1183
Cell biology international 2025 Sep;49(9):1173-1183
The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication.
Lan Q, Zhang X, Sun Y, Yang J, Li X, Kuang E
PLoS pathogens 2025 Sep;21(9):e1013509
PLoS pathogens 2025 Sep;21(9):e1013509
Impact of NLRP6 inflammasome on neuroinflammation in temporal lobe epilepsy.
Guo Y, Song J, Chen Y, Lü Y, Yu W
Neurochemistry international 2025 Sep;188:105994
Neurochemistry international 2025 Sep;188:105994
Curcumin suppresses NLRP3 inflammasome activation by inducing autophagy to alleviate neuropathic pain in rats.
Zhou T, Chen Z, Li S, Wang F, Tian W
Molecular biology reports 2025 Sep 3;52(1):859
Molecular biology reports 2025 Sep 3;52(1):859
Methamphetamine and HIV-1 Tat Synergistically Induce Microglial Pyroptosis Via Activation of the AIM2 Inflammasome.
Miao L, Wang H, Yang X, Xu L, Xu R, Teng H, Zhang Y, Zhao Y, Yang G, Zeng X
Inflammation 2025 Oct;48(5):3300-3313
Inflammation 2025 Oct;48(5):3300-3313
Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.
He SY, Bu YR, Xu J, Wang YM, Feng TX, Li PJ, Zhao YX, Ge YL, Xie MJ
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2225-2237
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2225-2237
Resveratrol glycoside inhibits NLRP3/IL-1β/NF-κB to alleviate peritoneal fibrosis in peritoneal dialysis.
Liu K, Huang Y, Xiao W, Liao J, Ouyang S, Liang Y, Fu J
Clinical and experimental nephrology 2025 Oct;29(10):1331-1341
Clinical and experimental nephrology 2025 Oct;29(10):1331-1341
Rottlerin inhibits PKCδ to attenuate pulmonary fibrosis by suppressing NLRC4/ASC-mediated pyroptosis.
Wang Y, Zhang T, Gou X, Yuan W, He S, Zhang S, Chen Z, Xu G, Wu D, Xu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157154
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157154
Targeting RelA/NLRP3/CCL3 axis mitigates microglia inflammatory response and promotes recovery after spinal cord injury.
Song W, Fu R, Yuan Z, Liu Y, Kao Y, Zhang R, Gu G, Zhu H, Liu H, Zhang Z, Kong X, Feng S
Brain, behavior, and immunity 2025 Oct;129:801-817
Brain, behavior, and immunity 2025 Oct;129:801-817
Yogurt alleviates alcohol-induced hepatocyte pyroptosis and inflammation via autophagy/P62/Nrf2/ROS/NLRP3 pathway.
Guan S, Wang Y, Zhang R, Yao X, Lu S, Deng X, Lu J
Journal of dairy science 2025 Oct;108(10):10489-10503
Journal of dairy science 2025 Oct;108(10):10489-10503
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Li L, Zuo A, Yin R, Liu Q, Liu C, Li N, Xu D, Zhang S, Li J, Lei S, Ruan S, Li T, Guo Y
Cell death & disease 2025 Oct 7;16(1):710
Cell death & disease 2025 Oct 7;16(1):710
Wuhu decoction regulates ROS/AMPK/mTOR pathway-mediated dendritic cells autophagy and pyroptosis for the treatment of respiratory syncytial virus-induced asthma.
Ding Y, Luo J, Deng YJ, Liu JL, Wang MQ, Hu Y
Journal of thoracic disease 2025 Oct 31;17(10):7810-7825
Journal of thoracic disease 2025 Oct 31;17(10):7810-7825
1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons.
Zhou W, Liu Z, Qiu X, Tian M, He B, Tang C, Tang Q, Ye R, Zhong D, Liao Y
International immunopharmacology 2025 Oct 30;164:115400
International immunopharmacology 2025 Oct 30;164:115400
Arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, improved kidney and pancreatic injury in vitro and in vivo in type 2 diabetes mellitus.
Tsopmejio ISN, Tang S, Gao XF, Liu Z, Li XD, Qi MH, Zhu HY, Wang Z, Li W
International immunopharmacology 2025 Oct 30;164:115378
International immunopharmacology 2025 Oct 30;164:115378
Auranofin Ameliorates Gouty Inflammation by Suppressing NLRP3 Activation and Neutrophil Migration via the IL-33/ST2-CXCL1 Axis.
Yoo H, Choi A, Kim M, Gye Y, Jo H, Kwok SK, Park Y, Lee JJ
Cells 2025 Oct 2;14(19)
Cells 2025 Oct 2;14(19)
OPA1 modulates NLRP3 inflammasome activation and microglial-mediated neuroinflammation in neonatal hypoxic-ischemic brain injury.
Lv Q, Hong F, Sun Z, Shen H, Lu H, Jin Y, Mao L, Song L
Journal of neuroimmunology 2025 Oct 15;407:578701
Journal of neuroimmunology 2025 Oct 15;407:578701
TREM-1 Promotes Microglial Pyroptosis and Mitochondrial Fission in Intracerebral Hemorrhage via the PI3K/AKT Pathway.
An Y, Zhai T, Wang F, Zhang K, Feng M, Song D, Li Z, Guo F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71115
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71115
MicroRNA-29a attenuates inflammation and fibrosis in an animal model of NASH through MCJ inhibition and hippo pathway regulation.
Yang YL, Huang YH
European journal of pharmacology 2025 Oct 15;1005:178107
European journal of pharmacology 2025 Oct 15;1005:178107
The role of Lactobacillus rhamnosus in improving estrogen deficiency-induced osteoporosis by inhibiting NLRP3 inflammasome activation.
Xiong K, Pan Y, Liu Y, Li J, Zhan D, Zhang L, Li J, Sun H
Biochemical and biophysical research communications 2025 Oct 10;784:152652
Biochemical and biophysical research communications 2025 Oct 10;784:152652
Corilagin alleviates radiation enteritis through caspase-1/gasdermin D-dependent pyroptosis by targeting aldo-keto reductase family 1 member C2 via glutathione metabolism.
Zhang SH, Zhang T, Wang XB, Yang YY, Chen ZX, Liu T, Deng SH, Liu YB, He X, Wu DM, Xu Y
International immunopharmacology 2025 Oct 10;163:115245
International immunopharmacology 2025 Oct 10;163:115245
A novel GPR84 antagonist attenuates diabetic lung injury by inhibiting pyroptosis via the cGAS-STING pathway in pulmonary vascular endothelial cells.
Gao W, Tong H, Yu H, Chen R, Wang Y, Liang L, Li Y, Ma Z
International immunopharmacology 2025 Oct 10;163:115190
International immunopharmacology 2025 Oct 10;163:115190
Saccharomyces boulardii Alleviates Ovalbumin-Induced Pyroptosis Through Cyba and IL-17 Signaling Pathway.
Chen Z, Hu L, Yang Y, Wang Y, Li Y, Su J, Wang G, Gong S
Molecular nutrition & food research 2025 Nov;69(21):e70194
Molecular nutrition & food research 2025 Nov;69(21):e70194
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Zhang F, Xie Y, Dang RN, Yu J, Tian XX, Li LJ, Zhou QM, An XM, Chen PL, Luo YQ, Wu YS, Liu J, Zou HM
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Tetramethylpyrazine protects against myocardial ischemia/reperfusion injury via regulating Myl2-mediated NLRP3 signaling pathway inhibition.
Li Y, Chen X, Yang M, Yan C, Zhang R, Zhang X, Zuo P, Carvalho A, Cao G, Ma G
Cellular signalling 2025 Nov;135:112045
Cellular signalling 2025 Nov;135:112045
Cisplatin transported by COX17 induces cochlear damage by binding Myosin IIA to regulate cell pyroptosis induced by mitochondrial dysfunction.
Peng J, Tao G, Chen X, Ai Y, Lai R, Liu W, Hu B, Xu Y, Xie B, Li L
Life sciences 2025 Nov 1;380:123961
Life sciences 2025 Nov 1;380:123961
Electroacupuncture pretreatment alleviates cerebral Ischemia-Reperfusion-Induced intestinal barrier injury and neuroinflammation via inhibition of the TLR4/NLRP3 inflammasome pathway in rats.
Ye T, Zhang N, Tan X, Zha Q, Chen C, Quan F, Cen W, Wu X
Brain research 2025 Nov 1;1866:149944
Brain research 2025 Nov 1;1866:149944
Early Potentially Irreversible Cardiac Damage in Fabry Disease Precedes Gb3 Inclusion Body Formation.
Lee CL, Chen PS, Lu YY, Chiang YT, Yen CT, Huang CY, Cheng YF, Lin HY, Chen YR, Niu DM
The Canadian journal of cardiology 2025 May;41(5):939-951
The Canadian journal of cardiology 2025 May;41(5):939-951
Gastrodin Ameliorates Tau Pathology and BBB Dysfunction in 3xTg-AD Transgenic Mice by Regulating the ADRA1/NF-κB/NLRP3 Pathway to Reduce Neuroinflammation.
Li B, Wang L, Xiao Y, Wang Y, Wang Y, Peng Y, Zhang A, Tang Z, Qi X
Phytotherapy research : PTR 2025 May;39(5):1996-2016
Phytotherapy research : PTR 2025 May;39(5):1996-2016
Protein glycopatterns for natural regulation of microbiota in lung adenocarcinoma.
Sagheer U, Shu J, Yu H, Ren X, Haroon K, Majeed U, Xu C, Zhang F, Xie H, Li Z
International journal of biological macromolecules 2025 May;306(Pt 3):141542
International journal of biological macromolecules 2025 May;306(Pt 3):141542
IL-33 facilitates endoplasmic reticulum stress and pyroptosis in LPS-stimulated ARDS model in vitro.
Li PL, Fu HM, Liu K, Liu HF, Sui MZ, Yang JW
Molecular immunology 2025 May;181:102-112
Molecular immunology 2025 May;181:102-112
Hippocampal NLRP1 inflammasome mediates anxiety-like behavior in mice with hypothyroidism.
Cheng YW, Zou ZH, Lou CL, Tong MR, Li JK, Zhu WH, Lu YL, Zhu DF, Xu Q, Xu YX
Scientific reports 2025 May 9;15(1):16176
Scientific reports 2025 May 9;15(1):16176
rhaFGF promotes acute diabetic wound healing by suppressing chronicity of inflammation.
Pang T, Shao Y, Zhou L, Wang Z, Xi P, Zhang Y, Xie L, Deng Z
Scientific reports 2025 May 30;15(1):19085
Scientific reports 2025 May 30;15(1):19085
Hyperandrogenism triggers mtDNA release to participate in ovarian inflammation via mPTP/cGAS/STING in PCOS.
Cai J, Zhu Q, Xiang Y, Weng L, Liang N, Hong X, Xue M, Ge H
iScience 2025 May 16;28(5):112391
iScience 2025 May 16;28(5):112391
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.
Xu H, Pang M, Hu C, Xu T, Chen G, Zhang G, Han X, Hua Y, Wu Y, Zhang J, Bi Y, Liu B, Zhou Y
Journal of ginseng research 2025 Mar;49(2):197-207
Journal of ginseng research 2025 Mar;49(2):197-207
E. coli Nissle 1917 improves gut microbiota composition and serum metabolites to counteract atherosclerosis via the homocitrulline/Caspase 1/NLRP3/GSDMD axis.
Liu H, Ma X, Yang X, Xiao S, Ouyang S, Hu Z, Zhou Z, Jiang Z
International journal of medical microbiology : IJMM 2025 Mar;318:151642
International journal of medical microbiology : IJMM 2025 Mar;318:151642
WISP1 promotes the progression of rheumatoid arthritis through NLRP3 inflammasome activation.
Hao T, Niu J, Tang Z, Xie K, Chen H, Wang H
Molecular immunology 2025 Mar;179:106-115
Molecular immunology 2025 Mar;179:106-115
Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.
Lian X, Guo Z, Liu J, Zeng W
Bulletin of experimental biology and medicine 2025 Mar;178(5):685-690
Bulletin of experimental biology and medicine 2025 Mar;178(5):685-690
The novel GSDMD inhibitor GI-Y2 exerts antipyroptotic effects to reduce atherosclerosis.
Fan X, Cheng Z, Shao R, Ye K, Chen X, Cai X, Dai S, Tang Z, Shi S, Zheng W, Huang W, Han J, Ye B
Clinical and translational medicine 2025 Mar;15(3):e70263
Clinical and translational medicine 2025 Mar;15(3):e70263
Oxaliplatin induces pyroptosis in hepatoma cells and enhances antitumor immunity against hepatocellular carcinoma.
Deng M, Zhao R, Zou H, Guan R, Wang J, Lee C, He B, Zhou J, Li S, Wei W, Cai H, Guo R
British journal of cancer 2025 Mar;132(4):371-383
British journal of cancer 2025 Mar;132(4):371-383
Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complex.
Zhang F, Zhang SH, Liu T, Xie GS, Deng SH, Zhang T, Wang XB, Yang YY, Chen ZX, Wu DM, Xu Y
Stem cell research & therapy 2025 Mar 7;16(1):121
Stem cell research & therapy 2025 Mar 7;16(1):121
Melatonin refines ovarian mitochondrial dysfunction in PCOS by regulating the circadian rhythm gene Clock.
Chen W, Zhang H, Guo B, Tao Y, Zhang J, Wang J, Chen G, Cheng M, Hong Q, Cao Y, Xie F
Cellular and molecular life sciences : CMLS 2025 Mar 6;82(1):104
Cellular and molecular life sciences : CMLS 2025 Mar 6;82(1):104
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p.
Yang Q, Chen Q, Zhang KB, Liu Y, Zheng JC, Hu DX, Luo J
Acta neuropathologica communications 2025 Mar 5;13(1):48
Acta neuropathologica communications 2025 Mar 5;13(1):48
Sodium butyrate alleviates spinal cord injury via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis.
Cui Y, Cen Q, Feng J, Wei J, Wang L, Chang C, Pang R, Wang J, Zhang A
Metabolic brain disease 2025 Mar 24;40(4):157
Metabolic brain disease 2025 Mar 24;40(4):157
Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the Brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD Mice.
Bhuiyan P, Zhang W, Liang G, Jiang B, Vera R, Chae R, Kim K, Louis LS, Wang Y, Liu J, Chuang DM, Wei H
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Mar 17;20(1):26
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Mar 17;20(1):26
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Fu X, Zhang Q, Chen Y, Li Y, Wang H
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Effects of electroacupuncture on neural function and the expression of inflammation-related proteins NLRP3/caspase-1 in rats with ischemic stroke.
Wang Z, Xi Y, Lan J, Yang J, Shi T, Xu S, Xing L, Pan P, Wang J
Neuroreport 2025 Jun 4;36(9):456-466
Neuroreport 2025 Jun 4;36(9):456-466
Transcranial magnetic stimulation through attenuating blood-spinal cord barrier disruption and reducing inflammatory response to improve motor function in rats with spinal cord injury.
Xu Q, Zhang Z, Zhai Y, Chen J, Xu J, Chen H, Lu J
Brain research bulletin 2025 Jun 15;226:111385
Brain research bulletin 2025 Jun 15;226:111385
PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.
Wei X, Yu C, Wang J
Connective tissue research 2025 Jul;66(4):298-310
Connective tissue research 2025 Jul;66(4):298-310
Shengjiang powder ameliorates cell pyroptosis and inflammation induced by MCAO in rats through the NLRP3/Caspase-1 pathway.
Qin L, Peng L, Sun Y, Chen G, Du C, Xie R, Ling Y, Xu H, Zhao M, Zhao Y, Zheng Z
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jul;34(7):108314
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jul;34(7):108314
Exploration of the Potential Bioactive Compounds and Functional Mechanism of Chaihu Sanshen Capsule in Ameliorating Myocardial Ischaemia-Reperfusion Injury: A Serum Pharmaco-Chemistry With Network Pharmacology Analysis.
Wang W, Zhang Z, Liu R, Zheng Y, Hu Y, Li X, Shen Z, Yuan H, Liu J
Journal of cellular and molecular medicine 2025 Jul;29(14):e70666
Journal of cellular and molecular medicine 2025 Jul;29(14):e70666
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
Tang H, Ning K, Wu B, Wang X, He J, Li P, Pan L, Zhang J, He Y, Bian S, Ma X, Zhang J, Liu C, Qin Z, Hu H
Biochemical pharmacology 2025 Jul;237:116932
Biochemical pharmacology 2025 Jul;237:116932
JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models.
Zhang P, Li Z, Liang M, Yuan J, Zhou J, Zhang J, Deng J, Chen Y, Tang H, Xu C, Shi C, Ma L, Liu Q, Liu Y, Chen Y, Zhang H
Cell communication and signaling : CCS 2025 Jul 8;23(1):327
Cell communication and signaling : CCS 2025 Jul 8;23(1):327
Hyperandrogenism-mediated YAP activation drives ovarian inflammation and pyroptosis in PCOS: implications for follicular dysfunction.
Xu T, Xiang Y, Huang Z, Zhu Q, Wu H, Cai J, Weng L, Ge H
Journal of ovarian research 2025 Jul 30;18(1):170
Journal of ovarian research 2025 Jul 30;18(1):170
Rosmarinic Acid Ameliorates Type 2 Diabetic Osteoporosis by Reducing NLRP3 Expression and Alleviating Osteoblast Pyroptosis via the FOXO1/TXNIP Signaling Pathway.
Feng S, Ma R, Huang Y, Pan L, Guo Y, Wang Y, Chen Z, Li E, Bu Y, Luo J, Tang J, Yang L
Journal of agricultural and food chemistry 2025 Jul 2;73(26):16557-16572
Journal of agricultural and food chemistry 2025 Jul 2;73(26):16557-16572
High-Fat Diet-Induced Diabetic Cardiomyopathy in Female Zebrafish: Cardiac Pathology and Functional Decline Mediated by Type 2 Diabetes.
Huang S, Chen Z, Li H, Zou Y, Wang B, Zhao W, Zheng L, Zhou Z, Peng X, Tang C
Nutrients 2025 Jul 2;17(13)
Nutrients 2025 Jul 2;17(13)
Downregulation of cardiac inflammation via the CaMKII δ/NF-κB pathway in heart failure by Lonicerae Japonicae Flos and Angelicae Sinensis Radix.
Tang J, Li X, Yu X, Wang D, Huang K, Pu H, Yu J, Li S, Wang W, Liu B, Guo S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156326
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156326
Proanthocyanidins alleviate acute alcohol liver injury by inhibiting pyroptosis via inhibiting the ROS-MLKL-CTSB-NLRP3 pathway.
Jin Y, Wang C, Meng Z, Zhang Y, Meng D, Liu J, Yuan M, Guan S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156268
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156268
CircFndc3b Mediates Exercise-Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice.
Zhao Y, He X, Yang X, Hong Z, Xu Y, Xu J, Zheng H, Zhang L, Zuo Z, Hu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2403818
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2403818
The aqueous extract of Armadillidium vulgare Latreille alleviates neuropathic pain via inhibiting neuron-astrocyte crosstalk mediated by the IL-12-IFN-γ-IFNGR-CXCL10 pathway.
Yang Y, Zhang S, Yang J, Yao C, Li X, Dai W, Liu J
Journal of ethnopharmacology 2025 Jan 31;340:119173
Journal of ethnopharmacology 2025 Jan 31;340:119173
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation.
Guo D, Wu J, Shen C, Zhang A, Zou T, Chen K, Huang W, Pan Y, Shen Y, Ji P, Zhong Y, Wen Q, Kong B, Xiang M, Ye B
Biogerontology 2025 Jan 31;26(2):49
Biogerontology 2025 Jan 31;26(2):49
Tangzu granule alleviate neuroinflammation in diabetic peripheral neuropathy by suppressing pyroptosis through P2X7R /NLRP3 signaling pathway.
Feng H, Wu T, Chin J, Ding R, Long C, Wang G, Yan D, Ma X, Yue R
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118792
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118792
Therapeutic effects of tripterygium glycosides on periodontitis: Exploring the role of ursolic acid and the RIPK3/NLRP3 signaling pathway.
Ren L, Gao Y, Chen L, Yang L
International immunopharmacology 2025 Jan 27;146:113903
International immunopharmacology 2025 Jan 27;146:113903
The injury effect of osteopontin in sepsis-associated lung injury.
Wang Q, Yu Z, Song Z, Lu X, Li Z, Pi D, Li J, Xu F
Journal of inflammation (London, England) 2025 Jan 24;22(1):4
Journal of inflammation (London, England) 2025 Jan 24;22(1):4
Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway.
Ni W, Zhao Y, Shen J, Yin Q, Wang Y, Li Z, Tang T, Wen Y, Zhang Y, Jiang W, Jiang L, Wei J, Gan W, Zhang A, Zhou X, Wang B, Liu BC
Chinese medical journal 2025 Jan 20;138(2):193-204
Chinese medical journal 2025 Jan 20;138(2):193-204
Ganoderic Acid A Alleviates Severe Acute Pancreatitis by Modulating Gut Homeostasis and Inhibiting TLR4-NLRP3 Signaling.
Zhang L, Wang K, Huang L, Deng B, Chen C, Zhao K, Wang W
Journal of agricultural and food chemistry 2025 Jan 15;73(2):1563-1579
Journal of agricultural and food chemistry 2025 Jan 15;73(2):1563-1579
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
Wang H, Zhang H, Miao L, Wang C, Teng H, Li X, Zhang X, Yang G, Wang S, Zeng X
Ecotoxicology and environmental safety 2025 Jan 15;290:117749
Ecotoxicology and environmental safety 2025 Jan 15;290:117749
Inhibition of tumor necrosis factor receptor-associated factor 6 alleviates secondary brain injury by reducing neuronal pyroptosis after intracerebral hemorrhage.
Hu Q, Zeng H, Feng C, Tian W, He Y, Li B
Experimental animals 2025 Jan 10;74(1):39-48
Experimental animals 2025 Jan 10;74(1):39-48
Puerarin reduces diabetic nephropathy-induced podocyte pyroptosis by modulating the SIRT1/NLRP3/caspase-1 pathway.
Wang L, Xie X, Chen Q, Chen Y, Xu X, Liang T
Molecular and cellular endocrinology 2025 Jan 1;595:112409
Molecular and cellular endocrinology 2025 Jan 1;595:112409
NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.
Liu Y, Wang W, Liang B, Zou Z, Zhang A
Ecotoxicology and environmental safety 2025 Jan 1;289:117504
Ecotoxicology and environmental safety 2025 Jan 1;289:117504
Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis.
Liu C, Huang X, Kong J, Li X, Wang Y, Zhang F, Duan J
Ecotoxicology and environmental safety 2025 Jan 1;289:117441
Ecotoxicology and environmental safety 2025 Jan 1;289:117441
Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the AMPK/SIRT1 Signaling Pathway.
Kuang G, Zhao Y, Wang L, Wen T, Liu P, Ma B, Peng Q, Xu F, Ye L, Fan J
Phytotherapy research : PTR 2025 Feb;39(2):733-746
Phytotherapy research : PTR 2025 Feb;39(2):733-746
Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway.
Li ZQ, Zhang F, Li Q, Wang L, Sun XQ, Li C, Yin XM, Liu CL, Wang YX, Du XY, Lu CZ
Chinese journal of integrative medicine 2025 Feb;31(2):118-130
Chinese journal of integrative medicine 2025 Feb;31(2):118-130
Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse.
Cheng SY, Yang YF, Wang YL, Yue ZP, Chen YZ, Wang WK, Xu ZR, Li LF, Shen H, Qi ZM, Xu CL, Liu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115201
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115201
FlaA N/C attenuates radiation-induced lung injury by promoting NAIP/NLRC4/ASC inflammasome autophagy and inhibiting pyroptosis.
Deng S, Yang Y, He S, Chen Z, Xia X, Zhang T, Yin Q, Liu T, Wu D, Pan K, Xu Y
Journal of translational medicine 2025 Feb 27;23(1):237
Journal of translational medicine 2025 Feb 27;23(1):237
Mechanistic studies of Ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation.
Xiang J, Lv M, Luo Y, Ke K, Zhang B, Wang M, Zhang K, Li H
Scientific reports 2025 Feb 24;15(1):6669
Scientific reports 2025 Feb 24;15(1):6669
Targeting the NLRP3 in macrophages contributes to senescence cell clearance in radiation-induced skin injury.
Liu G, Chen Y, Dai S, Wu G, Wang F, Chen W, Wu L, Luo P, Shi C
Journal of translational medicine 2025 Feb 18;23(1):196
Journal of translational medicine 2025 Feb 18;23(1):196
Lipotoxicity-induced upregulation of FIS1 exacerbates mitochondrial fragmentation and promotes NLRP3-dependent pyroptosis in diabetic cardiomyopathy.
Luo L, Wu Q, Xiao Q, Chen Y, Deng Z, Cen C, Lin J
Free radical biology & medicine 2025 Feb 16;228:183-196
Free radical biology & medicine 2025 Feb 16;228:183-196
Analysis of ferroptosis-related genes in cerebral ischemic stroke via immune infiltration and single-cell RNA-sequencing.
Fan W, Zheng J, Jiang F
BMC medical genomics 2025 Feb 11;18(1):31
BMC medical genomics 2025 Feb 11;18(1):31
Iodine activates NLRP3 inflammasomes in PBMCs of patients with autoimmune thyroiditis and regulates Th1 and Th17 cell differentiation.
Wu Y, Guo Q, Liu Y, Gong X, Sun W, Li Y, Fan C, Teng W, Shan Z
Endocrine connections 2025 Feb 1;14(2)
Endocrine connections 2025 Feb 1;14(2)
Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.
Sun B, Wu J, Li Z, Zhang Y, Lu X, Wang J, Xu X
International immunopharmacology 2025 Dec 3;166:115639
International immunopharmacology 2025 Dec 3;166:115639
Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.
Zhou P, Huang Y, Wang Z, Chen D, Long B, Qin P, Li Y, Yang C, Li Q
Molecular biomedicine 2025 Dec 29;6(1):150
Molecular biomedicine 2025 Dec 29;6(1):150
Brevilin A reverses colitis of inflammatory bowel disease via modulation of TNF-α signaling and microbiome dysregulation.
Chen L, Tang C, Hu D, Yu S, Liao P
Gut pathogens 2025 Dec 29;18(1):1
Gut pathogens 2025 Dec 29;18(1):1
Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.
Yu K, Liu M, Zhang T, Guo C, Du L, Li M, Wang Q, Han N, Chi Y, Li Y
Diabetology & metabolic syndrome 2025 Dec 2;18(1):7
Diabetology & metabolic syndrome 2025 Dec 2;18(1):7
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Chen X, Zhang F, Zhou Z, Jiang D, Wen L
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
Eukaryotic ADCY7 catalyzes the production of c-di-AMP to activate the NLRP3 inflammasome.
Liu Q, Tang Z, Qian Y, Wang C, Kong C, Li M, Geng X, Zhang Y, Cheng X, Ren C, Wang K, Bai L, Wang L, Jiang D, Wang S, Liu X, Xia P
Nature chemical biology 2025 Aug;21(8):1283-1291
Nature chemical biology 2025 Aug;21(8):1283-1291
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult.
Zhang T, Lv J, Liu ZY, Lei QL, Jiang ZF, Sun XX, Yue X, Li X, Zhu KL, Yang YK, Luo L, Cao X
Purinergic signalling 2025 Aug;21(4):637-649
Purinergic signalling 2025 Aug;21(4):637-649
Microglia specific Csf1r haploinsufficiency induces depressive-like behaviors by promoting NLRP6/caspase-1 signaling in mice.
Pang RK, Zheng JY, Xu HY, Zhao YQ, Su S, Le K, Cai YF, Zhang SJ, Li XX
Brain, behavior, and immunity 2025 Aug;128:383-399
Brain, behavior, and immunity 2025 Aug;128:383-399
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy.
Zhang S, Guo J, Liu M, Chen Y, Shen X, Wang J, Deng X, Guan S
Journal of dairy science 2025 Aug;108(8):7896-7911
Journal of dairy science 2025 Aug;108(8):7896-7911
Vitamin D improves diabetic cardiomyopathy by inhibiting pyroptosis through the NOX4/NLRP3 inflammasome pathway.
Wang D, Sun Z, Zhang H, Xiang J, Wu H, Lu C, Li M, Ma Y, Liu G, Wang L
Food & function 2025 Aug 11;16(16):6718-6732
Food & function 2025 Aug 11;16(16):6718-6732
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood-Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation.
Luo L, Hu Q, Yan R, Gao X, Zhang D, Yan Y, Liu Q, Mao S
Molecular neurobiology 2025 Apr;62(4):5252-5272
Molecular neurobiology 2025 Apr;62(4):5252-5272
Schistosoma mansoni soluble egg antigen suppresses colorectal cancer growth in vitro and in vivo.
Pekkle Lam HY, Liang TR, Jiang SJ, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2025 Apr;58(2):241-250
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2025 Apr;58(2):241-250
CEBPA as a potential hub gene for cutaneous inflammation in type 2 diabetes mellitus.
Han M, Wang J, Wu Y, Liao J, Guo J, Tang Z
International journal of biological macromolecules 2025 Apr;298:140080
International journal of biological macromolecules 2025 Apr;298:140080
Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity.
Tang CT, Wu Y, Tao Q, Zeng CY, Chen YX
Journal of pharmaceutical analysis 2025 Apr;15(4):101121
Journal of pharmaceutical analysis 2025 Apr;15(4):101121
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes.
Tan Y, Miao L, Wang C, Wang H, Li Y, Huang Y, Teng H, Tian Y, Yang G, Zeng X, Li J
Neurotoxicity research 2025 Apr 7;43(2):21
Neurotoxicity research 2025 Apr 7;43(2):21
Chrysophanol Attenuates Cardiac Fibrosis and Arrhythmia by Suppressing the Endoplasmic Reticulum Stress/Pyroptosis Axis and Inflammation.
Liu C, Qiu S, Liu X, Huang R, Fang Z
Phytotherapy research : PTR 2025 Apr 5;
Phytotherapy research : PTR 2025 Apr 5;
Salvianolic acid B (SalB) improves high-fat diet (HFD)-caused cognitive impairment in mice by modulating the Trem2/Dap12 pathway in vivo and in vitro.
Li HD, Zheng JY, Tan KW, Su JX, Chen W, Pang RK, Wu GL, Qiu YH, Li XX, Cai YF, Zhang SJ
International immunopharmacology 2025 Apr 24;153:114461
International immunopharmacology 2025 Apr 24;153:114461
Kanglexin attenuates spinal cord injury by modulating pyroptosis and polarization via the PKA/NF-κB signaling pathway.
Yan R, Yuan Y, Shi C, Li Y, Li Y, Wang W, Yang L
International immunopharmacology 2025 Apr 24;153:114401
International immunopharmacology 2025 Apr 24;153:114401
OAB-14 Attenuated Glymphatic System Disorder, Neuroinflammation and Dyskinesia in Parkinson's Disease Model Mice Induced by Rotenone.
Zhao X, Cao R, Tian X, Liu P, Liu D, Yu X, Zheng Z, Chen GL, Zou L
Neurochemical research 2025 Apr 12;50(2):142
Neurochemical research 2025 Apr 12;50(2):142
Extracellular Vesicle-Liposome-Darunavir Formulation for the Treatment of HIV Neuropathogenesis.
Zhou L, Godse S, Sinha N, Ma D, Mirzahosseini G, Salman M, Pulliam P, Tan C, Singh UP, Ishrat T, Kochat H, Kumar S
ACS applied nano materials 2025 Apr 11;8(14):6857-6876
ACS applied nano materials 2025 Apr 11;8(14):6857-6876
Interleukin 1β Mediates the Pathogenesis of Nasal Mucosal Epithelial Barrier Dysfunction in Allergic Rhinitis.
Wang H, Song X, Wang Y, Yang T, Liu W, Mou Y, Ren C, Song X
Journal of inflammation research 2024;17:9071-9085
Journal of inflammation research 2024;17:9071-9085
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
Li J, Du X, Mu Z, Han X
Journal of inflammation research 2024;17:8009-8026
Journal of inflammation research 2024;17:8009-8026
The AGEs/RAGE Signaling Pathway Regulates NLRP3-Mediated Neuronal Pyroptosis After MCAO Injury in Lepr(-/-) Obese Rats.
Zhao L, Li S, Wang X, Zhang L, Zhang J, Liu X, Hu Y, Xian X, Zhang F, Li W, Zhang M
Journal of inflammation research 2024;17:6935-6954
Journal of inflammation research 2024;17:6935-6954
Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
Sun M, Wang F, Li H, Li M, Wang Y, Wang C, Zhang Y, Zhang D, Li J, Yao S
Journal of inflammation research 2024;17:1349-1364
Journal of inflammation research 2024;17:1349-1364
(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway.
Li S, Zhang J, Zhao Y, Kang L, Jie H, Dong B
Frontiers in pharmacology 2024;15:1453647
Frontiers in pharmacology 2024;15:1453647
Effect of NLRP3 inflammasome induced astrocyte phenotype alteration in morphine tolerance.
Yuan Z, Lu B, Zhang M, Lu Y, Wang Z, Zhang W, Cheng H, Wu Z, Ji Q
Frontiers in pharmacology 2024;15:1434295
Frontiers in pharmacology 2024;15:1434295
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Zhao J, Chen C, Ge L, Jiang Z, Hu Z, Yin L
Frontiers in immunology 2024;15:1386780
Frontiers in immunology 2024;15:1386780
USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis.
Zhao C, Mu M, Li X, Dong Z, Wang J, Yao C, Zheng J, Sun X, Yu J
Frontiers in immunology 2024;15:1326137
Frontiers in immunology 2024;15:1326137
Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation.
Zhang Q, Yang XR, Deng Y
Cell biochemistry and biophysics 2024 Sep;82(3):2275-2283
Cell biochemistry and biophysics 2024 Sep;82(3):2275-2283
GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis.
Xie X, Shen X, Liu Y, Zuo Y, Wang S, Zhou Y, Li X, Wang K, Li B, Wang Z
Archives of biochemistry and biophysics 2024 Sep;759:110102
Archives of biochemistry and biophysics 2024 Sep;759:110102
Microglia and Astrocytes Responses Contribute to Alleviating Inflammatory Damage by Repetitive Transcranial Magnetic Stimulation in Rats with Traumatic Brain Injury.
Qian F, He R, Du X, Wei Y, Zhou Z, Fan J, He Y
Neurochemical research 2024 Sep;49(9):2636-2651
Neurochemical research 2024 Sep;49(9):2636-2651
Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome.
Li Y, Tian L, Li S, Chen X, Lei F, Bao J, Wu Q, Wen Y, Jie Y
Free radical biology & medicine 2024 Sep;222:106-121
Free radical biology & medicine 2024 Sep;222:106-121
Disulfiram attenuates cell and tissue damage and blood‒brain barrier dysfunction after intracranial haemorrhage by inhibiting the classical pyroptosis pathway.
Xu C, Jiang F, Mao Y, Wei W, Song J, Jia F, Du X, Zhong D, Li G
Scientific reports 2024 Sep 19;14(1):21860
Scientific reports 2024 Sep 19;14(1):21860
Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome.
Xue J, Jiang C, Chen X, Wang L
International immunopharmacology 2024 Sep 10;138:112591
International immunopharmacology 2024 Sep 10;138:112591
β-Caryophyllene mitigates ischemic stroke-induced white matter lesions by inhibiting pyroptosis.
Xin Q, Xu F, Ma Z, Wu J
Experimental cell research 2024 Sep 1;442(1):114214
Experimental cell research 2024 Sep 1;442(1):114214
Targeting Mitochondrial Oxidative Stress to Protect Against Preterm Birth and Fetal Brain Injury via Nrf2 Induction.
Chen C, Zhu S, Fu T, Chen Y, Bai L, Chen D
Antioxidants & redox signaling 2024 Oct;41(10-12):597-615
Antioxidants & redox signaling 2024 Oct;41(10-12):597-615
Identification of a novel caspase cleavage motif AEAD.
Fang Y, Gong Z, You M, Peng K
Virologica Sinica 2024 Oct;39(5):755-766
Virologica Sinica 2024 Oct;39(5):755-766
Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to participate in stroke injury and post-stroke anxiety like behavior.
Yang M, Zhu H, Peng L, Yin T, Sun S, Du Y, Li J, Liu J, Wang S
Experimental neurology 2024 Oct;380:114906
Experimental neurology 2024 Oct;380:114906
Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α.
Su X, Li Q, Yang M, Zhang W, Liu X, Ba Y, Deng Q, Zhang Y, Han L, Huang H
Experimental neurology 2024 Oct;380:114899
Experimental neurology 2024 Oct;380:114899
IL-18, a therapeutic target for immunotherapy boosting, promotes temozolomide chemoresistance via the PI3K/AKT pathway in glioma.
Ji H, Lan Y, Xing P, Wang Z, Zhong X, Tang W, Wei Q, Chen H, Liu B, Guo H
Journal of translational medicine 2024 Oct 21;22(1):951
Journal of translational medicine 2024 Oct 21;22(1):951
Anti irradiation nanoparticles shelter immune organ from radio-damage via preventing the IKK/IκB/NF-κB activation.
Huang S, Xu M, Deng X, Da Q, Li M, Huang H, Zhao L, Jing L, Wang H
Molecular cancer 2024 Oct 19;23(1):234
Molecular cancer 2024 Oct 19;23(1):234
Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells.
Shi W, Zhou Q, Lu L, Zhang Y, Zhang H, Pu Y, Yin L
Ecotoxicology and environmental safety 2024 Oct 15;285:117085
Ecotoxicology and environmental safety 2024 Oct 15;285:117085
The phosphorylation of Smad3 by CaMKIIγ leads to the hepatocyte pyroptosis under perfluorooctane sulfonate exposure.
Ren S, Liang P, Feng R, Yang W, Qiu T, Zhang J, Li Q, Yang G, Sun X, Yao X
Ecotoxicology and environmental safety 2024 Oct 1;284:116924
Ecotoxicology and environmental safety 2024 Oct 1;284:116924
Gut microbiome and metabolites mediate the benefits of caloric restriction in mice after acute kidney injury.
Zhu XX, Fu X, Meng XY, Su JB, Zheng GL, Xu AJ, Chen G, Zhang Y, Liu Y, Hou XH, Qiu HB, Sun QY, Hu JY, Lv ZL, Wang Y, Jiang HB, Bao N, Han ZJ, Lu QB, Sun HJ
Redox biology 2024 Nov;77:103373
Redox biology 2024 Nov;77:103373
HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS-induced acute kidney injury.
Huang L, Wu Y, Sai W, Wang Y, Feng G, Lu Y, Chen F, Huang X, Zhao H, Gu Z, Yang B
Journal of cellular and molecular medicine 2024 Nov;28(22):e70202
Journal of cellular and molecular medicine 2024 Nov;28(22):e70202
GATA1-activated lncRNA OIP5-AS1 and GAS5 promote pyroptosis to exacerbate asthma through regulating miR-136-5p/LIFR axis.
Zhao S, Huang S, Wu Y, Yao X, Cai X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 30;38(22):e70159
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 30;38(22):e70159
SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway.
Luo P, Gu Q, Wang J, Li X, Li N, Yang W, Meng X, Zhao M
European journal of medical research 2024 Nov 29;29(1):567
European journal of medical research 2024 Nov 29;29(1):567
Intranasal dantrolene nanoparticles inhibit inflammatory pyroptosis in 5XFAD mice brains.
Bhuiyan P, Zhang W, Chae R, Kim K, St Louis L, Wang Y, Liang G, Wei H
bioRxiv : the preprint server for biology 2024 Nov 25;
bioRxiv : the preprint server for biology 2024 Nov 25;
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis.
Zhang Y, Wu R, Zhan X, Wang XY, Xiang LW, Duan YQ, You Y, Zhang JB, Wu R, Zhang YY, Duan L
Cell communication and signaling : CCS 2024 Nov 20;22(1):556
Cell communication and signaling : CCS 2024 Nov 20;22(1):556
Sulfiredoxin 1 ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the Sirt1/NLRP3 pathway.
Zhang Z, Du T, Wu N, Yang S, Wang J, Peng J, Jia Z, Dai J, Du X, Feng M, Chu H, Shen C
International immunopharmacology 2024 Nov 15;141:113010
International immunopharmacology 2024 Nov 15;141:113010
UCP2 knockout exacerbates sepsis-induced intestinal injury by promoting NLRP3-mediated pyroptosis.
Huang B, Lin G, Chen F, Yang W, Zhang C, Yao Y, Zeng Q, Yang Y, Huang J
International immunopharmacology 2024 Nov 15;141:112935
International immunopharmacology 2024 Nov 15;141:112935
Mechanics-activated fibroblasts promote pulmonary group 2 innate lymphoid cell plasticity propelling silicosis progression.
He Y, Yang F, Yang L, Yuan H, You Y, Chen Y, Wu X, Min H, Chen J, Li C
Nature communications 2024 Nov 12;15(1):9770
Nature communications 2024 Nov 12;15(1):9770
The role of NLRP3 inflammasome-mediated neuroinflammation in chronic noise-induced impairment of learning and memory ability.
Ren Y, Wu K, He Y, Zhang H, Ma J, Li C, Ruan Y, Zhang J, Wen Y, Wu X, Chen S, Qiu H, Zhang Y, Zhou L, Ou Z, Liang J, Wang Z
Ecotoxicology and environmental safety 2024 Nov 1;286:117183
Ecotoxicology and environmental safety 2024 Nov 1;286:117183
Hexavalent chromium exposure induces lung injury via activation of NLRP3 and AIM2 inflammasomes in rats.
Li N, Li S, Yu Y, Zhang X, Wu H, Li X, Jia G, Yu S
Ecotoxicology and environmental safety 2024 Nov 1;286:117181
Ecotoxicology and environmental safety 2024 Nov 1;286:117181
Inhibition of SPARC signal by aerobic exercise to ameliorate atherosclerosis.
Hu S, Zhang X, Ding Y, Liu X, Xia R, Wang X
International immunopharmacology 2024 May 10;132:111856
International immunopharmacology 2024 May 10;132:111856
α-Ketoglutarate Improves Ovarian Reserve Function in Primary Ovarian Insufficiency by Inhibiting NLRP3-Mediated Pyroptosis of Granulosa Cells.
Liu K, Wu Y, Yang W, Li T, Wang Z, Xiao S, Peng Z, Li M, Xiong W, Li M, Chen X, Zhang S, Lei X
Molecular nutrition & food research 2024 Mar;68(5):e2300784
Molecular nutrition & food research 2024 Mar;68(5):e2300784
Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway.
Liu MH, Lin XL, Xiao LL
Molecular medicine reports 2024 Mar;29(3)
Molecular medicine reports 2024 Mar;29(3)
Correlational analysis of PLIN1 with inflammation in diabetic foot ulcer wounds.
Wang M, Cao X, Shang Y, Jiang Y, Chen P, Duan C, Zhang D, Wang P, Ji J, Gong Z
Diabetes research and clinical practice 2024 Mar;209:111605
Diabetes research and clinical practice 2024 Mar;209:111605
Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats.
Chen H, Sun H, Hua W, Chang H, Chen W, Ma S
European journal of pharmacology 2024 Mar 5;966:176344
European journal of pharmacology 2024 Mar 5;966:176344
NRF2 activation ameliorates blood-brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation.
Fan W, Chen H, Li M, Fan X, Jiang F, Xu C, Wang Y, Wei W, Song J, Zhong D, Li G
Scientific reports 2024 Mar 4;14(1):5300
Scientific reports 2024 Mar 4;14(1):5300
Triclosan induces liver injury in long-life exposed mice via activation of TLR4/NF-κB/NLRP3 pathway.
Peng Y, Cui H, Shu C, Wei Z, Ni X, Liu J
Ecotoxicology and environmental safety 2024 Mar 15;273:116115
Ecotoxicology and environmental safety 2024 Mar 15;273:116115
Cyclin-dependent kinase inhibitor 1A inhibits pyroptosis to enhance human lung adenocarcinoma cell radioresistance by promoting DNA repair.
Li J, Liu T, Tang N, Lin S, Zhang F, Yuan W, Zhang T, Deng SH, Wu DM, Xu Y
Heliyon 2024 Mar 15;10(5):e26975
Heliyon 2024 Mar 15;10(5):e26975
Taohong Siwu decoction reduces acute myocardial ischemia-reperfusion injury by promoting autophagy to inhibit pyroptosis.
Yang Y, Zhu Y, Liu C, Cheng J, He F
Journal of ethnopharmacology 2024 Mar 1;321:117515
Journal of ethnopharmacology 2024 Mar 1;321:117515
P2Y(13) receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation.
Yin S, Yang X, Li H, Li C, Li C, Chen C, Ye S, Zou L, Liang S, Liu S
Neuropharmacology 2024 Mar 1;245:109818
Neuropharmacology 2024 Mar 1;245:109818
Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation.
Yang R, Li DD, Li XX, Yang XX, Gao HM, Zhang F
International journal of biological macromolecules 2024 Jun;269(Pt 2):132179
International journal of biological macromolecules 2024 Jun;269(Pt 2):132179
Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling.
Shi C, Wang Y, Guo J, Zhang D, Zhang Y, Gong Z
Cell death discovery 2024 Jun 8;10(1):275
Cell death discovery 2024 Jun 8;10(1):275
Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS.
Cihankaya H, Bader V, Winklhofer KF, Vorgerd M, Matschke J, Stahlke S, Theiss C, Matschke V
Cells 2024 Jun 7;13(12)
Cells 2024 Jun 7;13(12)
3-MCPD Induces Renal Cell Pyroptosis and Inflammation by Inhibiting ESCRT-III-Mediated Cell Repair and Mitophagy.
Zhang R, Guan S, Meng Z, Deng X, Lu J
Journal of agricultural and food chemistry 2024 Jun 10;
Journal of agricultural and food chemistry 2024 Jun 10;
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.
Li X, Tang X, Xiang Y, Zhao Z, Li Y, Ding Q, Zhang L, Xu J, Zhao L, Chen Y
American journal of physiology. Gastrointestinal and liver physiology 2024 Jun 1;326(6):G697-G711
American journal of physiology. Gastrointestinal and liver physiology 2024 Jun 1;326(6):G697-G711
Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration.
Sun J, Zeng Q, Wu Z, Huang L, Sun T, Ling C, Zhang B, Chen C, Wang H
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Jul;21(4):e00347
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Jul;21(4):e00347
The antidepressant effect of Shexiang Baoxin Pills on myocardial infarction rats with depression may be achieved through the inhibition of the NLRP3 inflammasome pathway.
Wang Y, Chen Y, Li B, Zhou Y, Guan J, Huang F, Wu J, Dong Y, Sun P, Tian X, Cai J, Ran F, Dai Q, Lv J
Brain and behavior 2024 Jul;14(7):e3586
Brain and behavior 2024 Jul;14(7):e3586
Uric acid-lowering effect of harpagoside and its protective effect against hyperuricemia-induced renal injury in mice.
Fu Q, Zhang JJ, Zhu QF, Yu LL, Wang F, Li J, He X, Ao JL, Xu GB, Wei MC, Liao XJ, Liao SG
Biochemical and biophysical research communications 2024 Jul 5;716:150038
Biochemical and biophysical research communications 2024 Jul 5;716:150038
Sestrin2 Restricts Endothelial-to-Mesenchymal Transition Induced by Lipolysaccharide via Autophagy.
Huang R, Liu L, Shen K, Duan C, Fan Z
Journal of integrative neuroscience 2024 Jul 5;23(7):124
Journal of integrative neuroscience 2024 Jul 5;23(7):124
Effect and mechanism of T lymphocytes on human induced pluripotent stem cell-derived cardiomyocytes via Proteomics.
Ye J, Xu S, Liu X, Zhang Q, Li X, Zhang H, Ma J, Leng L, Zhang S
Stem cell research & therapy 2024 Jul 29;15(1):236
Stem cell research & therapy 2024 Jul 29;15(1):236
EZH2-STAT3 signaling pathway regulates GSDMD-mediated pyroptosis in glioblastoma.
Yu D, Wang S, Wang J, Zhang K, Niu Z, Lin N
Cell death discovery 2024 Jul 28;10(1):341
Cell death discovery 2024 Jul 28;10(1):341
Disulfiram downregulates ferredoxin 1 to maintain copper homeostasis and inhibit inflammation in cerebral ischemia/reperfusion injury.
Yang S, Li X, Yan J, Jiang F, Fan X, Jin J, Zhang W, Zhong D, Li G
Scientific reports 2024 Jul 2;14(1):15175
Scientific reports 2024 Jul 2;14(1):15175
CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase‑1‑dependent pyroptosis.
Zheng Y, Yang S, Dai W, Wang J, Bi S, Zhang X, Zheng Z, Sun Y, Wu S, Kong J
International journal of oncology 2024 Jan;64(1)
International journal of oncology 2024 Jan;64(1)
A novel stroke rehabilitation strategy and underlying stress granule regulations through inhibition of NLRP3 inflammasome activation.
Wang Q, Kohls W, Wills M, Li F, Pang Q, Geng X, Ding Y
CNS neuroscience & therapeutics 2024 Jan;30(1):e14405
CNS neuroscience & therapeutics 2024 Jan;30(1):e14405
Empagliflozin alleviates the development of autoimmune myocarditis via inhibiting NF-κB-dependent cardiomyocyte pyroptosis.
Lv C, Hu C, Zhu C, Wan X, Chen C, Ji X, Qin Y, Lu L, Guo X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115963
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115963
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
Tong Z, Kong L, Zhang Y, Hu T, Dai R, Wang Y, Ji J, Huang Z, Hu L
Bioorganic chemistry 2024 Jan;142:106955
Bioorganic chemistry 2024 Jan;142:106955
Yunvjian decoction attenuates lipopolysaccharide-induced periodontitis by suppressing NFκB/NLRP3/IL-1β pathway.
Ye Q, Lin B, Xu P, Zhang F, Wang N, Shou D
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117279
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117279
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Zhang B, He Z, Guo J, Li F, Huang Z, Zheng W, Xing W, Li M, Zhu Y, Yang X
Aging 2024 Jan 26;16(2):1145-1160
Aging 2024 Jan 26;16(2):1145-1160
The improvement of homocysteine-induced myocardial inflammation by vitamin D depends on activation of NFE2L2 mediated MTHFR.
Liu N, Su H, Lou Y, Kong J
International immunopharmacology 2024 Jan 25;127:111437
International immunopharmacology 2024 Jan 25;127:111437
Rutin prevents pyroptosis and M1 microglia via Nrf2/Mac-1/caspase-1-mediated inflammasome axis to improve POCD.
Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Jin D, Xu L, Ge S
International immunopharmacology 2024 Jan 25;127:111290
International immunopharmacology 2024 Jan 25;127:111290
SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis.
Gu Q, Xia H, Song YQ, Duan J, Chen Y, Zhang Y, Chen HP, Zhang L
World journal of gastroenterology 2024 Jan 21;30(3):252-267
World journal of gastroenterology 2024 Jan 21;30(3):252-267
SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus.
Ye X, Lin JY, Chen LX, Wu XC, Ma KJ, Li BX, Fang YX
Heliyon 2024 Jan 15;10(1):e23945
Heliyon 2024 Jan 15;10(1):e23945
Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.
Tang S, Lai N, Xu L
Brain research 2024 Jan 1;1822:148666
Brain research 2024 Jan 1;1822:148666
SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.
Liu MH, Lin XL, Xiao LL
Tissue & cell 2024 Feb;86:102276
Tissue & cell 2024 Feb;86:102276
Demethylase FTO-Mediated m6A Modification of lncRNA MEG3 Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke.
Yan H, Huang W, Rao J, Yan D, Yuan J
Molecular neurobiology 2024 Feb;61(2):1023-1043
Molecular neurobiology 2024 Feb;61(2):1023-1043
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Li L, Kong L, Xu S, Wang C, Gu J, Luo H, Meng Q
Hepatology international 2024 Feb;18(1):188-205
Hepatology international 2024 Feb;18(1):188-205
L-ascorbyl-2-phosphate alleviates white matter injury caused by chronic hypoxia through the PRMT5/P53/NF-κB pathway.
Ding B, Lou J, Qin T, Xie W, Li D, Li P, Wang X, Lin Z, Guo X, Zhu J
Journal of neurochemistry 2024 Feb;168(2):142-160
Journal of neurochemistry 2024 Feb;168(2):142-160
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice.
Zhou Y, Zhao Q, Zhang Y, Di L, Xue F, Xu W, Gao W, Guo Y, He Y, Kou J, Qin Y, Xie X, Du L, Han G, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155298
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155298
ENST00000534735 inhibits proliferation and migration, promotes apoptosis and pyroptosis of endometrial cancer via OSBPL3 through APMK/SIRT1/NF-κB pathway.
Shan S, Wang X, Qian L, Wang C, Zhao S
Heliyon 2024 Feb 29;10(4):e25281
Heliyon 2024 Feb 29;10(4):e25281
Transplantation of olfactory ensheathing cells can alleviate neuroinflammatory responses in rats with trigeminal neuralgia.
Lu J, Yang B, Zhang W, Cheng H, Zeng J, Wang Y, Wei W, Liu Z
Brain research 2024 Feb 15;1825:148732
Brain research 2024 Feb 15;1825:148732
CTRP3 inhibits myocardial fibrosis through the P2X7R-NLRP3 inflammasome pathway in SHR rats.
Liu N, Gong Z, Li Y, Xu Y, Guo Y, Chen W, Sun X, Yin X, Liu W
Journal of hypertension 2024 Feb 1;42(2):315-328
Journal of hypertension 2024 Feb 1;42(2):315-328
Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation.
Hu Y, Nan Y, Lin H, Zhao Q, Chen T, Tao X, Ding B, Lu L, Chen S, Zhu J, Guo X, Lin Z
Pediatric research 2024 Dec;96(7):1681-1692
Pediatric research 2024 Dec;96(7):1681-1692
Corynoline alleviates hepatic ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling.
Ge X, Gu Y, Wang W, Guo W, Wang P, Du P
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Dec;73(12):2069-2085
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Dec;73(12):2069-2085
An Amino Acids and Dipeptide Injection Inhibits the TNF-α/HMGB1 Inflammatory Signaling Pathway to Reduce Pyroptosis and M1 Microglial Polarization in POCD Mice: the Gut to the Brain.
Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Xu L, Ge S
Molecular neurobiology 2024 Dec;61(12):10097-10114
Molecular neurobiology 2024 Dec;61(12):10097-10114
Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells.
Zhao P, Ning J, Huang J, Huang X
Autoimmunity 2024 Dec;57(1):2427094
Autoimmunity 2024 Dec;57(1):2427094
Interleukin-18 interacts with NKCC1 to mediate brain injury after intracerebral hemorrhage.
Xu B, Li H, Zheng H, Gao Z, Miao Z, Xu X, Yang H, Yang Y
Brain, behavior, & immunity - health 2024 Dec;42:100890
Brain, behavior, & immunity - health 2024 Dec;42:100890
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
Yu B, Yuan C, Chen J, Zhou Z, Zhang Y, Su M, Wei D, Wu P
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
Lipopolysaccharide-regulated RNF31/NRF2 axis in colonic epithelial cells mediates homeostasis of the intestinal barrier in ulcerative colitis.
Tang CT, Liu ZD, Wang P, Zeng CY, Chen YX
Cellular signalling 2024 Dec;124:111480
Cellular signalling 2024 Dec;124:111480
Outer Membrane Vesicles Derived From Fusobacterium nucleatum Trigger Periodontitis Through Host Overimmunity.
Zhang L, Zhang D, Liu C, Tang B, Cui Y, Guo D, Duan M, Tu Y, Zheng H, Ning X, Liu Y, Chen H, Huang M, Niu Z, Zhao Y, Liu X, Xie J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2400882
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2400882
Fucoidan from Laminaria japonica protects renal tubular epithelial cells from uric acid induced NLRP3-mediated pyroptosis through inhibition of NF-κB pathway.
Tan X, Zhang Y, Luo P, Lin Z, Li F, Liu H
Journal of ethnopharmacology 2024 Dec 5;335:118614
Journal of ethnopharmacology 2024 Dec 5;335:118614
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Yun WJ, Li J, Yin NC, Zhang CY, Cui ZG, Zhang L, Zheng HC
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Cancer biology & therapy 2024 Dec 31;25(1):2302162
SUCNR 1 promotes atherosclerosis by inducing endoplasmic reticulum stress mediated ER-mito crosstalk.
Yuan C, Yu B, Li L, Chen J, Qin W, Zhou Z, Su M, Wang D, Zhang Y, Wu Q, He C, Wei D
International immunopharmacology 2024 Dec 25;143(Pt 3):113510
International immunopharmacology 2024 Dec 25;143(Pt 3):113510
METTL3-mediated m(6)A modification of CD36: Implications for glucose metabolism and inflammatory dysregulation in follicles of polycystic ovary syndrome.
Weng L, Zhu Q, Xiang Y, Cao T, Cai J, Liang N, Hong X, Xue M, Ge H
International immunopharmacology 2024 Dec 25;143(Pt 1):113327
International immunopharmacology 2024 Dec 25;143(Pt 1):113327
Electroacupuncture extends the time window of thrombolytic therapy in rats by reducing disruptions of blood-brain barrier and inhibiting GSDMD-mediated pyroptosis.
Liu H, Shen Y, Huang Z, Jiang T, Huang P, Yang M, Zhang X, Xu W, Ni G
Brain research 2024 Dec 15;1845:149296
Brain research 2024 Dec 15;1845:149296
Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD mice.
Bhuiyan P, Zhang W, Liang G, Jiang B, Vera R, Chae R, Kim K, Louis LS, Wang Y, Liu J, Chuang DM, Wei H
bioRxiv : the preprint server for biology 2024 Dec 12;
bioRxiv : the preprint server for biology 2024 Dec 12;
Sweroside alleviates pressure overload-induced heart failure through targeting CaMKⅡδ to inhibit ROS-mediated NF-κB/NLRP3 in cardiomyocytes.
Wang D, Yu X, Gao K, Li F, Li X, Pu H, Zhang P, Guo S, Wang W
Redox biology 2024 Aug;74:103223
Redox biology 2024 Aug;74:103223
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease.
Wang XF, Xiang XH, Wei J, Zhang PB, Xu Q, Liu MH, Qu LQ, Wang XX, Yu L, Wu AG, Qing DL, Wu JM, Law BY, Yu CL, Yong-Tang
Neurochemical research 2024 Aug;49(8):2197-2214
Neurochemical research 2024 Aug;49(8):2197-2214
A2 reactive astrocyte-derived exosomes alleviate cerebral ischemia-reperfusion injury by delivering miR-628.
Wang Y, Li H, Sun H, Xu C, Sun H, Wei W, Song J, Jia F, Zhong D, Li G
Journal of cellular and molecular medicine 2024 Aug;28(16):e70004
Journal of cellular and molecular medicine 2024 Aug;28(16):e70004
Bisphenol S exposure induces intestinal inflammation via altering gut microbiome.
Li S, Ma X, Zhang X, Bai S, Li X, Huang Y, Yu J, Fan Y, Lu C, Du G, Qin Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Aug;190:114830
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Aug;190:114830
Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis.
Shen H, Lu H, Mao L, Song L
Translational pediatrics 2024 Aug 31;13(8):1378-1394
Translational pediatrics 2024 Aug 31;13(8):1378-1394
Combined bacterial translocation and cholestasis aggravates liver injury by activation pyroptosis in obstructive jaundice.
Shen X, Zhang X, Li K, Huang G, Li X, Hou Y, Ge X
Heliyon 2024 Aug 30;10(16):e35793
Heliyon 2024 Aug 30;10(16):e35793
Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization.
Yang X, Sun A, Kong L, Yang X, Zhao X, Wang S
International immunopharmacology 2024 Aug 20;137:112374
International immunopharmacology 2024 Aug 20;137:112374
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854
Journal of hazardous materials 2024 Aug 15;475:134854
Matrine Suppresses Arsenic-Induced Malignant Transformation of SV-HUC-1 Cells via NOX2.
Wang L, Qiu N, Tong S, Yu Y, Xi S, Wang F
International journal of molecular sciences 2024 Aug 15;25(16)
International journal of molecular sciences 2024 Aug 15;25(16)
Capsaicin alleviates acute alcohol-induced pyroptosis by activating ESCRT-III-dependent cell membrane repair in hepatocytes.
Liu M, Guo J, Lu J, Chen Y, Deng X, Zhang S, Guan S
Food & function 2024 Aug 12;15(16):8395-8407
Food & function 2024 Aug 12;15(16):8395-8407
Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.
Zhang A, Pan Y, Wang H, Ding R, Zou T, Guo D, Shen Y, Ji P, Huang W, Wen Q, Wang Q, Hu H, Wu J, Xiang M, Ye B
Aging cell 2024 Apr;23(4):e14091
Aging cell 2024 Apr;23(4):e14091
Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and TXNIP for binding to NLRP3 inflammasome in response to neuroinflammation.
Luo J, Luo Y, Chen J, Gao Y, Tan J, Yang Y, Yang C, Jiang N, Luo Y
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167056
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167056
Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy.
Zhang R, Guan S, Meng Z, Zhang D, Lu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114522
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114522
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.
Xiao Y, Liu X, Xie K, Luo J, Zhang Y, Huang X, Luo J, Tan S
Clinical and translational medicine 2024 Apr;14(4):e1653
Clinical and translational medicine 2024 Apr;14(4):e1653
Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.
Wang TB, He Y, Li RC, Yu YX, Liu Y, Qi ZQ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155448
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155448
TMAO promotes vascular endothelial cell pyroptosis via the LPEAT-mitophagy pathway.
Chen Y, Yuan C, Qin W, Yu B, Wei D, Wu P
Biochemical and biophysical research communications 2024 Apr 9;703:149667
Biochemical and biophysical research communications 2024 Apr 9;703:149667
Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells.
Liu M, Lu J, Hu J, Chen Y, Deng X, Wang J, Zhang S, Guo J, Li W, Guan S
Journal of hazardous materials 2024 Apr 5;467:133719
Journal of hazardous materials 2024 Apr 5;467:133719
The GFPT2-O-GlcNAcylation-YBX1 axis promotes IL-18 secretion to regulate the tumor immune microenvironment in pancreatic cancer.
Zhang HR, Li TJ, Yu XJ, Liu C, Wu WD, Ye LY, Jin KZ
Cell death & disease 2024 Apr 4;15(4):244
Cell death & disease 2024 Apr 4;15(4):244
Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes.
Chen F, Xing Y, Chen Z, Chen X, Li J, Gong S, Luo F, Cai Q
European journal of medical research 2024 Apr 24;29(1):250
European journal of medical research 2024 Apr 24;29(1):250
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats.
Jia X, Ju J, Li Z, Peng X, Wang J, Gao F
European journal of pharmacology 2024 Apr 15;969:176428
European journal of pharmacology 2024 Apr 15;969:176428
Garlic oil supplementation blocks inflammatory pyroptosis-related acute lung injury by suppressing the NF-κB/NLRP3 signaling pathway via H(2)S generation.
Dilxat T, Shi Q, Chen X, Liu X
Aging 2024 Apr 12;16(7):6521-6536
Aging 2024 Apr 12;16(7):6521-6536
Galangin Prevents Against Ethanol-Induced Intestinal Barrier Dysfunction and NLRP3 Inflammasome Activation via NF-κB/MAPK Signaling Pathways in Mice and Caco-2 Cells.
Zhao Y, Li B, Liu J, Chen L, Teng H
Journal of agricultural and food chemistry 2024 Apr 11;
Journal of agricultural and food chemistry 2024 Apr 11;
GroEL triggers NLRP3 inflammasome activation through the TLR/NF-κB p-p65 axis in human periodontal ligament stem cells.
Zhang L, Duan M, Pu X, Zheng H, Ning X, Tu Y, Xu C, Zhang D, Liu C, Xie J
Acta biochimica et biophysica Sinica 2024 Apr 10;56(9):1340-1351
Acta biochimica et biophysica Sinica 2024 Apr 10;56(9):1340-1351
Mechanisms of resveratrol against diabetic wound by network pharmacology and experimental validation.
Youjun D, Huang Y, Lai Y, Ma Z, Wang X, Chen B, Ding X, Tan Q
Annals of medicine 2023;55(2):2280811
Annals of medicine 2023;55(2):2280811
Histone H3 activates caspase-1 and promotes proliferation and metastasis in hepatocellular carcinoma.
Jing M, Qiong L, Wang Z, Xiong X, Fu Y, Yan W
International journal of medical sciences 2023;20(5):689-701
International journal of medical sciences 2023;20(5):689-701
High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis.
Zhu Y, Chi J, Cai S, Liu S, Yuan J, Xu H, Zhou H
International journal of medical sciences 2023;20(12):1570-1583
International journal of medical sciences 2023;20(12):1570-1583
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
An JR, Liu JT, Gao XM, Wang QF, Sun GY, Su JN, Zhang C, Yu JX, Yang YF, Shi Y
Frontiers in cellular neuroscience 2023;17:1136070
Frontiers in cellular neuroscience 2023;17:1136070
Single-cell landscape of immune cells during the progression from HBV infection to HBV cirrhosis and HBV-associated hepatocellular carcinoma.
Bai Q, Li R, He X, Hong X, Yan Y, Zhao Z, Lin H, Tacke F, Engelmann C, Hu T
Frontiers in immunology 2023;14:1320414
Frontiers in immunology 2023;14:1320414
Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation.
Tang S, Liang Y, Wang M, Lei J, Peng Y, Tao Q, Ming T, Yang W, Zhang C, Guo J, Xu H
Frontiers in immunology 2023;14:1285550
Frontiers in immunology 2023;14:1285550
The Role of Endophilin A1 in Lipopolysaccharide-Induced Parkinson's Disease Model Mice.
Han J, Liu M, Ling Y, Ren Y, Qiu Y, Liu Y, Yin Y
Journal of Parkinson's disease 2023;13(5):743-756
Journal of Parkinson's disease 2023;13(5):743-756
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Xu L, Zeng Z, Niu C, Liu D, Lin S, Liu X, Szabó G, Lu J, Zheng S, Zhou P
Frontiers in cardiovascular medicine 2023;10:1126391
Frontiers in cardiovascular medicine 2023;10:1126391
STING deletion alleviates podocyte injury through suppressing inflammation by targeting NLRP3 in diabetic kidney disease.
Yang X, Chen Z, Luo Z, Yang D, Hao Y, Hu J, Feng J, Zhu Z, Luo Q, Zhang Z, Liang W, Ding G
Cellular signalling 2023 Sep;109:110777
Cellular signalling 2023 Sep;109:110777
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis.
Zhou D, Zhu Y, Jiang P, Zhang T, Zhuang J, Li T, Qi L, Wang Y
Biological research 2023 Sep 27;56(1):50
Biological research 2023 Sep 27;56(1):50
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis.
Kong X, Zhao Y, Wang X, Yu Y, Meng Y, Yan G, Yu M, Jiang L, Song W, Wang B, Wang X
Chemico-biological interactions 2023 Sep 1;382:110640
Chemico-biological interactions 2023 Sep 1;382:110640
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Yang Z, Wu S, He S, Han L, Zhou M, Yang J, Chen J, Wu G
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
HMGB1 induces macrophage pyroptosis in chronic endometritis.
Yang G, Zhang Q, Tan J, Xiong Y, Liang Y, Yan J, Gu F, Xu Y
International immunopharmacology 2023 Oct;123:110706
International immunopharmacology 2023 Oct;123:110706
Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway.
Zhao Y, Shao C, Zhou H, Yu L, Bao Y, Mao Q, Yang J, Wan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155002
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155002
Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs/NF-kB and pyroptosis pathways.
Jiang Z, Zeng Z, He H, Li M, Lan Y, Hui J, Bie P, Chen Y, Liu H, Fan H, Xia H
Journal of translational medicine 2023 Oct 31;21(1):770
Journal of translational medicine 2023 Oct 31;21(1):770
Cordyceps militaris Solid Medium Extract Alleviates Lipoteichoic Acid-Induced MH-S Inflammation by Inhibiting TLR2/NF-κB/NLRP3 Pathways.
Wang X, Peng Z, Wang L, Zhang J, Zhang K, Guo Z, Xu G, Li J
International journal of molecular sciences 2023 Oct 24;24(21)
International journal of molecular sciences 2023 Oct 24;24(21)
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer.
Su P, Mao X, Ma J, Huang L, Yu L, Tang S, Zhuang M, Lu Z, Osafo KS, Ren Y, Wang X, Lin X, Huang L, Huang X, Braicu EI, Sehouli J, Sun P
Journal of experimental & clinical cancer research : CR 2023 Oct 20;42(1):274
Journal of experimental & clinical cancer research : CR 2023 Oct 20;42(1):274
CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis.
Zhang H, Deng Z, Wang Y, Zheng X, Zhou L, Yan S, Wang Y, Dai Y, Kanwar YS, Deng F
iScience 2023 Oct 20;26(10):107762
iScience 2023 Oct 20;26(10):107762
Colchicine protects against the development of experimental abdominal aortic aneurysm.
Zhao Y, Shen QR, Chen YX, Shi Y, Wu WB, Li Q, Li DJ, Shen FM, Fu H
Clinical science (London, England : 1979) 2023 Oct 11;137(19):1533-1545
Clinical science (London, England : 1979) 2023 Oct 11;137(19):1533-1545
Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke.
Yu L, Zhang Z, Chen H, Wang M, Mao W, Hu J, Zuo D, Lv B, Wu W, Qi S, Cui G
Bioengineering & translational medicine 2023 Nov;8(6):e10590
Bioengineering & translational medicine 2023 Nov;8(6):e10590
Oxalate‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling in vitro and in vivo.
Chen Y, Yang S, Kong H, Wang Q, Chen S, Wang X, Chen L, Qi S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Elaidic acid induced hepatocyte pyroptosis via autophagy-CTSB-NLRP3 pathway.
Lu J, Chen Z, Bu X, Chen S, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114060
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114060
Polydatin protects against calcium oxalate crystal-induced renal injury through the cytoplasmic/mitochondrial reactive oxygen species-NLRP3 inflammasome pathway.
Liu J, Huang J, Gong B, Cheng S, Liu Y, Chen Y, Feng Q, Li J, Qiu M, Yu G, Liao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115621
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115621
The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice.
Liu M, Ling Y, Zhang Y, Liu L, Qiu Y, Liu Y, Yin Y
International immunopharmacology 2023 Nov;124(Pt B):111023
International immunopharmacology 2023 Nov;124(Pt B):111023
Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.
Wang C, Dong M, Zhang X, Wang X, Zhao Y, Cao Y
Acta biochimica Polonica 2023 Nov 7;70(4):807-815
Acta biochimica Polonica 2023 Nov 7;70(4):807-815
Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice.
Wang J, Zhang S, Hu L, Wang Y, Liu K, Le J, Tan Y, Li T, Xue H, Wei Y, Zhong O, He J, Zi D, Lei X, Deng R, Luo Y, Tang M, Su M, Cao Y, Liu Q, Tang Z, Lei X
Cell death & disease 2023 Nov 7;14(11):723
Cell death & disease 2023 Nov 7;14(11):723
Homer1 Protects against Retinal Ganglion Cell Pyroptosis by Inhibiting Endoplasmic Reticulum Stress-Associated TXNIP/NLRP3 Inflammasome Activation after Middle Cerebral Artery Occlusion-Induced Retinal Ischemia.
Lv W, Wu X, Dou Y, Yan Y, Chen L, Fei Z, Fei F
International journal of molecular sciences 2023 Nov 27;24(23)
International journal of molecular sciences 2023 Nov 27;24(23)
Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro-survival.
Ye M, Liu T, Liu S, Tang R, Liu H, Zhang F, Luo S, Li M
Cell death discovery 2023 Nov 25;9(1):425
Cell death discovery 2023 Nov 25;9(1):425
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer.
Xie W, Peng M, Liu Y, Zhang B, Yi L, Long Y
Cell communication and signaling : CCS 2023 Nov 16;21(1):329
Cell communication and signaling : CCS 2023 Nov 16;21(1):329
CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
Li J, Wang H, Liu D, Li X, He L, Pan J, Shen Q, Peng Y
Brain, behavior, and immunity 2023 May;110:60-79
Brain, behavior, and immunity 2023 May;110:60-79
HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.
Zhong X, Wang Y, Liu D, Liang Y, Liu W, Huang Y, Xie L, Cao W, Xu Y, Chen L
Neuroscience 2023 May 1;517:117-127
Neuroscience 2023 May 1;517:117-127
DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury.
Zhou Z, Shang L, Zhang Q, Hu X, Huang JF, Xiong K
Biochimica et biophysica acta. Molecular cell research 2023 Mar;1870(3):119433
Biochimica et biophysica acta. Molecular cell research 2023 Mar;1870(3):119433
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Chen L, Mao M, Liu D, Liu W, Wang Y, Xie L, Deng Y, Lin Y, Xu Y, Zhong X, Cao W
International immunopharmacology 2023 Mar;116:109648
International immunopharmacology 2023 Mar;116:109648
Achyranthoside D attenuates chondrocyte loss and inflammation in osteoarthritis via targeted regulation of Wnt3a.
Xie W, Qi S, Dou L, Wang L, Wang X, Bi R, Li N, Zhang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154663
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154663
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Chen Y, Wang L, Huang ZS, Feng JX, Li SX, Du ZJ, Zhang ZB, Liu J, Yang J, Hu ZM, Wang ZL, Chen J
Andrology 2023 Mar;11(3):591-610
Andrology 2023 Mar;11(3):591-610
Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.
Guan X, Shen S, Liu J, Song H, Chang J, Mao X, Song J, Zhang L, Liu C
BMC complementary medicine and therapies 2023 Mar 6;23(1):72
BMC complementary medicine and therapies 2023 Mar 6;23(1):72
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.
Jiang B, Wang S, Song G, Jiang Q, Fan M, Fang C, Li X, Soh CL, Manes TD, Cheru N, Qin L, Ren P, Jortner B, Wang Q, Quaranta E, Yoo P, Geirsson A, Davis RP, Tellides G, Pober JS, Jane-Wit D
Science signaling 2023 Mar 21;16(777):eabo3406
Science signaling 2023 Mar 21;16(777):eabo3406
The expression of cyclic GMP-AMP synthase in human apical periodontitis: A laboratory investigation.
Yang F, Liu L, Wang L, Ji X, Zeng Y, Du J, Zhang L, Huang D
International endodontic journal 2023 Jun;56(6):710-721
International endodontic journal 2023 Jun;56(6):710-721
Salmonella typhimurium exacerbates injuries but resolves fibrosis in liver and spleen during Schistosoma mansoni infection.
Lam HYP, Wu WJ, Liang TR, Li HC, Chang KC, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2023 Jun;56(3):477-489
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2023 Jun;56(3):477-489
LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis.
He W, Duan L, Zhang L
Korean circulation journal 2023 Jun;53(6):387-403
Korean circulation journal 2023 Jun;53(6):387-403
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy.
Xu XX, Shi RX, Fu Y, Wang JL, Tong X, Zhang SQ, Wang N, Li MX, Tong Y, Wang W, He M, Liu BY, Chen GL, Guo F
Neural regeneration research 2023 Jun;18(6):1277-1285
Neural regeneration research 2023 Jun;18(6):1277-1285
Growth differentiation factor 15 protects the airway by inhibiting cell pyroptosis in obese asthmatic mice through the phosphoinositide 3-kinase/AKT pathway.
Li N, He F, Shang Y
International immunopharmacology 2023 Jun;119:110149
International immunopharmacology 2023 Jun;119:110149
Combined exposure to lead and high-fat diet induced neuronal deficits in rats: Anti-neuroinflammatory role of SIRT1.
Liu M, Liu R, Yang M, Ba Y, Deng Q, Zhang Y, Han L, Gao L, Huang H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113857
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113857
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Liu P, Zhou Y, Shi J, Wang F, Yang X, Zheng X, Wang Y, He Y, Xie X, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Bai Y, Zhang L, Zheng B, Zhang X, Zhang H, Zhao A, Yu J, Yang Z, Wen J
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Song D, Zhang A, Hu X, Zeng M, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
Liu J, Cao C, Jin Y, Wang Y, Ma X, Li J, Guo S, Yang J, Niu J, Liang X
iScience 2023 Jul 21;26(7):107022
iScience 2023 Jul 21;26(7):107022
RGD1564534 represses NLRP3 inflammasome activity in cerebral injury following ischemia-reperfusion by impairing miR-101a-3p-mediated Dusp1 inhibition.
Fan W, Qin Y, Tan J, Li B, Liu Y, Rong J, Shi W, Yu B
Experimental neurology 2023 Jan;359:114266
Experimental neurology 2023 Jan;359:114266
Alternate-day fasting for the protection of cognitive impairment in c57BL/6J mice following whole-brain radiotherapy.
Wu Q, Yu M, Wang Z, Ai X, Liu Z, Zeng J, Li C, Yuan L, He J, Lin X, Wan W
Neurochemistry international 2023 Jan;162:105463
Neurochemistry international 2023 Jan;162:105463
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation.
Sun K, Zhang H, Zhang T, Sun N, Hao J, Wang Z, Gao C
Molecular pain 2023 Jan-Dec;19:17448069231218352
Molecular pain 2023 Jan-Dec;19:17448069231218352
Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats.
Zhou J, Zhang C, Fang X, Zhang N, Zhang X, Zhu Z
BMC neuroscience 2023 Jan 28;24(1):9
BMC neuroscience 2023 Jan 28;24(1):9
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Tian Y, Feng X, Zhou Z, Qin S, Chen S, Zhao J, Hou J, Liu D
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223-3p/NLRP3 axis.
Hou L, Zhu Z, Jiang F, Zhao J, Jia Q, Jiang Q, Wang H, Xue W, Wang Y, Tian L
Ecotoxicology and environmental safety 2023 Feb;251:114537
Ecotoxicology and environmental safety 2023 Feb;251:114537
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons.
Yan WT, Zhao WJ, Hu XM, Ban XX, Ning WY, Wan H, Zhang Q, Xiong K
Neural regeneration research 2023 Feb;18(2):357-363
Neural regeneration research 2023 Feb;18(2):357-363
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS
Archives of toxicology 2023 Dec;97(12):3209-3226
Archives of toxicology 2023 Dec;97(12):3209-3226
Astragaloside IV ameliorate acute alcohol-induced liver injury in mice via modulating gut microbiota and regulating NLRP3/caspase-1 signaling pathway.
Wu S, Wen F, Zhong X, Du W, Chen M, Wang J
Annals of medicine 2023 Dec;55(1):2216942
Annals of medicine 2023 Dec;55(1):2216942
Regulating NLRP3 Inflammasome-Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia.
Wang M, Zhang F, Ning X, Wu C, Zhou Y, Gou Z, Fan Y, Duan R, Li Z, Shao C, Lu L
Inflammation 2023 Dec;46(6):2386-2401
Inflammation 2023 Dec;46(6):2386-2401
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
Zhong B, Sun S, Tan KS, Ong HH, Du J, Liu F, Liu Y, Liu S, Ba L, Li J, Wang Y, Liu J
The Journal of allergy and clinical immunology 2023 Dec;152(6):1444-1459.e14
The Journal of allergy and clinical immunology 2023 Dec;152(6):1444-1459.e14
The E3 ubiquitin ligase RNF31 mediates the development of ulcerative colitis by regulating NLRP3 inflammasome activation.
Wang P, Tang CT, Li J, Huang X, Jin R, Yin F, Liu Z, Chen Y, Zeng C
International immunopharmacology 2023 Dec;125(Pt B):111194
International immunopharmacology 2023 Dec;125(Pt B):111194
Yi-Qi-Jian-Pi formula inhibits hepatocyte pyroptosis through the IDH2-driven tricarboxylic acid cycle to reduce liver injury in acute-on-chronic liver failure.
Zhao R, Zhao Q, Wang X, Chen X, Liang C, Xiao Q, Yang S, Tan S
Journal of ethnopharmacology 2023 Dec 5;317:116683
Journal of ethnopharmacology 2023 Dec 5;317:116683
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y, Guo Z
Biological research 2023 Dec 2;56(1):62
Biological research 2023 Dec 2;56(1):62
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Pei X, Tang S, Jiang H, Zhang W, Xu G, Zuo Z, Ren Z, Chen C, Shen Y, Li C, Li D
The Science of the total environment 2023 Dec 15;904:166885
The Science of the total environment 2023 Dec 15;904:166885
The Comparative Effects of Schwann Cells and Wharton's Jelly Mesenchymal Stem Cells on the AIM2 Inflammasome Activity in an Experimental Model of Spinal Cord Injury.
Kharazinejad E, Hassanzadeh G, Sahebkar A, Yousefi B, Reza Sameni H, Majidpoor J, Golchini E, Taghdiri Nooshabadi V, Mousavi M
Neuroscience 2023 Dec 15;535:1-12
Neuroscience 2023 Dec 15;535:1-12
The role of ROS-pyroptosis in PM(2.5) induced air-blood barrier destruction.
Wei M, Cong Y, Lei J, Du R, Yang M, Lu X, Jiang Y, Cao R, Meng X, Jiang Z, Song L
Chemico-biological interactions 2023 Dec 1;386:110782
Chemico-biological interactions 2023 Dec 1;386:110782
A novel long noncoding RNA-lncRNA-AABR07066529.3 alleviates inflammation, apoptosis, and pyroptosis by inhibiting MyD88 in lipopolysaccharide-induced myocardial depression.
Wen R, Zhang TN, Zhang T, Tong YJ, Song WL, Liu YP, Yang N, Liu CF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23063
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23063
Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2.
Wang Y, Chen H, Fan X, Xu C, Li M, Sun H, Song J, Jia F, Wei W, Jiang F, Li G, Zhong D
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Aug;32(8):107235
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Aug;32(8):107235
Effects of sodium metabisulfite on pyroptosis, mitophagy and degranulation in mast cells.
Liu M, Lu J, Liu Q, Chen Y, Wang G, Zhang Q, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113918
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113918
Sodium houttuyfonate plays a protective role in the asthmatic airway by alleviating the NLRP3-related pyroptosis and Th1/Th2 immune imbalance.
Li M, Wang C, Xu WT, Zhong X
Molecular immunology 2023 Aug;160:103-111
Molecular immunology 2023 Aug;160:103-111
Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model.
Cao H, Yang D, Nie K, Lin R, Peng L, Zhou X, Zhang M, Zeng Y, Liu L, Huang W
European journal of pharmacology 2023 Aug 5;952:175670
European journal of pharmacology 2023 Aug 5;952:175670
Transcriptomics Reveals Molecular Features of the Bilateral Pelvic Nerve Injury Rat Model of Detrusor Underactivity.
Wang J, Ren L, Liu X, Xu W, Liu M, Hu P, Wang T, Liu J, Ling Q
Biomolecules 2023 Aug 18;13(8)
Biomolecules 2023 Aug 18;13(8)
Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R(-/-)mice.
Wang F, Yao W, Yu D, Hao Y, Wu Y, Zhang X
BMC gastroenterology 2023 Aug 11;23(1):276
BMC gastroenterology 2023 Aug 11;23(1):276
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
Sun MX, Qiao FX, Xu ZR, Liu YC, Xu CL, Wang HL, Qi ZQ, Liu Y
Free radical biology & medicine 2023 Aug 1;204:313-324
Free radical biology & medicine 2023 Aug 1;204:313-324
Melatonin inhibits atherosclerosis progression via galectin-3 downregulation to enhance autophagy and inhibit inflammation.
Wang Z, Gao Z, Zheng Y, Kou J, Song D, Yu X, Dong B, Chen T, Yang Y, Gao X, Wang Q, Ye T, Yang W, Zhang X, Li H, Yang L
Journal of pineal research 2023 Apr;74(3):e12855
Journal of pineal research 2023 Apr;74(3):e12855
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Dong C, Song C, He Z, Song Q, Song T, Liu J, Xiong Y, Su X, Zhou J, Yang S, Liao W
International immunopharmacology 2023 Apr;117:110042
International immunopharmacology 2023 Apr;117:110042
Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B.
Lam HYP, Liang TR, Peng SY
Nutrients 2023 Apr 15;15(8)
Nutrients 2023 Apr 15;15(8)
lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.
Liang G, Zeng M, Gao M, Xing W, Jin X, Wang Q, Deng L, Ou H, He Z
Oxidative medicine and cellular longevity 2022;2022:9369035
Oxidative medicine and cellular longevity 2022;2022:9369035
Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy.
Li S, Dong S, Shi B, Xu Q, Li L, Wang S, Zhang W, Zhong M, Zhu J, Cheng Y, Zhang G, Hu S
Oxidative medicine and cellular longevity 2022;2022:4608914
Oxidative medicine and cellular longevity 2022;2022:4608914
Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease.
Hu Y, Tang W, Liu W, Hu Z, Pan C
Drug design, development and therapy 2022;16:1605-1620
Drug design, development and therapy 2022;16:1605-1620
Sodium Tanshinone IIA Sulfonate Inhibits Vascular Endothelial Cell Pyroptosis via the AMPK Signaling Pathway in Atherosclerosis.
Zhu J, Chen H, Guo J, Zha C, Lu D
Journal of inflammation research 2022;15:6293-6306
Journal of inflammation research 2022;15:6293-6306
P2X7R-NEK7-NLRP3 Inflammasome Activation: A Novel Therapeutic Pathway of Qishen Granule in the Treatment of Acute Myocardial Ischemia.
Li Y, Sun X, Liu X, Li J, Li X, Wang G, Liu Y, Lu X, Cui L, Shao M, Wang Y, Wang W, Li C
Journal of inflammation research 2022;15:5309-5326
Journal of inflammation research 2022;15:5309-5326
Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway.
Li L, Deng S, Liu M, Yang M, Li J, Liu T, Zhang T, Zhao Y, He M, Wu D, Xu Y
Frontiers in pharmacology 2022;13:956402
Frontiers in pharmacology 2022;13:956402
Qingchang Wenzhong Decoction Prevents the Occurrence of Intestinal Tumors by Regulating Intestinal Microbiota and Gasdermin E.
Ren L, Zhang Z, Zhao W, Zhao B, Chen X, Wang Y, Chen Z, Ye J, Yang Y, Cao P
Frontiers in physiology 2022;13:917323
Frontiers in physiology 2022;13:917323
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Luo C, Peng Y, Zhou X, Fan J, Chen W, Zhang H, Wei A
Frontiers in endocrinology 2022;13:913296
Frontiers in endocrinology 2022;13:913296
Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro.
Gao G, Fu L, Xu Y, Tao L, Guo T, Fang G, Zhang G, Wang S, Qin T, Luo P, Shen X
Frontiers in pharmacology 2022;13:906548
Frontiers in pharmacology 2022;13:906548
Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway.
Chai Y, Cai Y, Fu Y, Wang Y, Zhang Y, Zhang X, Zhu L, Miao M, Yan T
Frontiers in pharmacology 2022;13:812362
Frontiers in pharmacology 2022;13:812362
(-)-Epicatechin Ameliorates Monosodium Urate-Induced Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and the NF-κB Signaling Pathway.
Wu C, Li F, Zhang X, Xu W, Wang Y, Yao Y, Han Z, Xia D
Frontiers in pharmacology 2022;13:799552
Frontiers in pharmacology 2022;13:799552
Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p.
Song JJ, Li H, Wang N, Zhou XY, Liu Y, Zhang Z, Feng Q, Chen YL, Liu D, Liang J, Ma XY, Wen XR, Fu YY
Frontiers in pharmacology 2022;13:1044375
Frontiers in pharmacology 2022;13:1044375
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
Yu J, Tang R, Li J
Frontiers in oncology 2022;12:991165
Frontiers in oncology 2022;12:991165
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.
Long Q, Li L, Yang H, Lu Y, Yang H, Zhu Y, Tang Y, Liu C, Yuan J
International immunopharmacology 2022 Sep;110:109024
International immunopharmacology 2022 Sep;110:109024
Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome.
Fu H, Shen QR, Zhao Y, Ni M, Zhou CC, Chen JK, Chi C, Li DJ, Liang G, Shen FM
Acta pharmacologica Sinica 2022 Oct;43(10):2585-2595
Acta pharmacologica Sinica 2022 Oct;43(10):2585-2595
Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade.
Xiang T, Li JH, Su HY, Bai KH, Wang S, Traub RJ, Cao DY
The journal of pain 2022 Oct;23(10):1629-1645
The journal of pain 2022 Oct;23(10):1629-1645
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE.
Zhong X, Chen Z, Wang Y, Mao M, Deng Y, Shi M, Xu Y, Chen L, Cao W
Brain research bulletin 2022 Oct 15;189:174-183
Brain research bulletin 2022 Oct 15;189:174-183
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Zhao AN, Yang Z, Wang DD, Shi B, Zhang H, Bai Y, Yan BW, Zhang Y, Wen JK, Wang XL, Qu CB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
Gao Y, Xiao X, Luo J, Wang J, Peng Q, Zhao J, Jiang N, Zhao Y
International journal of molecular sciences 2022 Nov 7;23(21)
International journal of molecular sciences 2022 Nov 7;23(21)
Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats.
Xiao Q, Kang Z, Liu C, Tang B
Frontiers in bioscience (Landmark edition) 2022 Nov 3;27(11):300
Frontiers in bioscience (Landmark edition) 2022 Nov 3;27(11):300
linc00174 deteriorates the pathogenesis of diabetic retinopathy via miR-26a-5p/PTEN/Akt signalling cascade-mediated pyroptosis.
Wang JJ, Chen ZL, Wang DD, Wu KF, Huang WB, Zhang LQ
Biochemical and biophysical research communications 2022 Nov 19;630:92-100
Biochemical and biophysical research communications 2022 Nov 19;630:92-100
LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.
Gu J, Shi JZ, Wang YX, Liu L, Wang SB, Sun JT, Shan TK, Wang H, Wang QM, Wang LS
Journal of cellular and molecular medicine 2022 May;26(10):2895-2907
Journal of cellular and molecular medicine 2022 May;26(10):2895-2907
Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway.
Xiao L, Li X, Cao P, Fei W, Zhou H, Tang N, Liu Y
Journal of experimental & clinical cancer research : CR 2022 May 5;41(1):166
Journal of experimental & clinical cancer research : CR 2022 May 5;41(1):166
Apigenin alleviated PA-induced pyroptosis by activating autophagy in hepatocytes.
Meng Z, Zhu B, Gao M, Wang G, Zhou H, Lu J, Guan S
Food & function 2022 May 23;13(10):5559-5570
Food & function 2022 May 23;13(10):5559-5570
Esculetin inhibits the pyroptosis of microvascular endothelial cells through NF-κB /NLRP3 signaling pathway.
Ren W, Zhou Q, Yu R, Liu Z, Hu Y
Archives of biochemistry and biophysics 2022 May 15;720:109173
Archives of biochemistry and biophysics 2022 May 15;720:109173
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.
Wang F, Liang Q, Ma Y, Sun M, Li T, Lin L, Sun Z, Duan J
Free radical biology & medicine 2022 Mar;182:171-181
Free radical biology & medicine 2022 Mar;182:171-181
Platonin protects against cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasomes via BNIP3/LC3 signaling mediated autophagy.
Luo J, Tan J, Jiang N, Yang C, Chen J, Zhao J, Li L, Zhao Y
Brain research bulletin 2022 Mar;180:12-23
Brain research bulletin 2022 Mar;180:12-23
Qishen granule (QSG) exerts cardioprotective effects by inhibiting NLRP3 inflammasome and pyroptosis in myocardial infarction rats.
Chen X, Li Y, Li J, Liu T, Jiang Q, Hong Y, Wang Q, Li C, Guo D, Wang Y
Journal of ethnopharmacology 2022 Mar 1;285:114841
Journal of ethnopharmacology 2022 Mar 1;285:114841
Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.
Song L, Yao S, Zheng D, Xuan Y, Li W
International urology and nephrology 2022 Jun;54(6):1355-1364
International urology and nephrology 2022 Jun;54(6):1355-1364
α(1) -Adrenoceptors activate the NLRP3 inflammasome through downregulation of Kir2.1 in cardiac inflammation.
Chen L, Wang W, Peng X, Liu L, Zhang A, Li X, Ma K, Wang L
Experimental physiology 2022 Jun;107(6):589-600
Experimental physiology 2022 Jun;107(6):589-600
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Kou L, Chi X, Sun Y, Han C, Wan F, Hu J, Yin S, Wu J, Li Y, Zhou Q, Zou W, Xiong N, Huang J, Xia Y, Wang T
Journal of neuroinflammation 2022 Jun 6;19(1):133
Journal of neuroinflammation 2022 Jun 6;19(1):133
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Han N, Wang Z, Luo H, Chi Y, Zhang T, Wang B, Li Y
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells.
Yu C, Wang D, Li Q, Tong Y, Yang Z, Wang T
International immunopharmacology 2022 Jul;108:108872
International immunopharmacology 2022 Jul;108:108872
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway.
Zhang K, Chai B, Ji H, Chen L, Ma Y, Zhu L, Xu J, Wu Y, Lan Y, Li H, Feng Z, Xiao J, Zhang H, Xu K
Laboratory investigation; a journal of technical methods and pathology 2022 Jan;102(1):90-101
Laboratory investigation; a journal of technical methods and pathology 2022 Jan;102(1):90-101
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32
Cancer cell international 2022 Jan 18;22(1):32
Alliin alleviates LPS-induced pyroptosis via promoting mitophagy in THP-1 macrophages and mice.
Liu M, Lu J, Yang S, Chen Y, Yu J, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Feb;160:112811
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Feb;160:112811
IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence.
Chiang HY, Lu HH, Sudhakar JN, Chen YW, Shih NS, Weng YT, Shui JW
Nature communications 2022 Feb 15;13(1):874
Nature communications 2022 Feb 15;13(1):874
Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway.
Cai Q, Sun Z, Xu S, Jiao X, Guo S, Li Y, Wu H, Yu X
Renal failure 2022 Dec;44(1):1169-1181
Renal failure 2022 Dec;44(1):1169-1181
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
Tang Q, Liu W, Yang X, Tian Y, Chen J, Hu Y, Fu N
DNA and cell biology 2022 Dec;41(12):1038-1052
DNA and cell biology 2022 Dec;41(12):1038-1052
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
Shi Y, Zhao L, Wang J, Liu S, Zhang Y, Qin Q
European journal of pharmacology 2022 Dec 15;937:175364
European journal of pharmacology 2022 Dec 15;937:175364
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Chen J, Peng H, Chen C, Wang Y, Sang T, Cai Z, Zhao Q, Chen S, Lin X, Eling T, Wang X
Life sciences 2022 Dec 15;311(Pt A):121142
Life sciences 2022 Dec 15;311(Pt A):121142
Protective Effect and Mechanism of Melatonin on Cisplatin-Induced Ovarian Damage in Mice.
Xing F, Wang M, Ding Z, Zhang J, Ding S, Shi L, Xie Q, Ahmad MJ, Wei Z, Tang L, Liang D, Cao Y, Liu Y
Journal of clinical medicine 2022 Dec 12;11(24)
Journal of clinical medicine 2022 Dec 12;11(24)
Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome.
Zheng X, Gong T, Tang C, Zhong Y, Shi L, Fang X, Chen D, Zhu Z
BMC anesthesiology 2022 Dec 1;22(1):371
BMC anesthesiology 2022 Dec 1;22(1):371
Use of wogonin as a cooperative drug with praziquantel to better combat schistosomiasis.
Pekkle Lam HY, Hung MY, Cheng PC, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2022 Aug;55(4):757-765
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2022 Aug;55(4):757-765
Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.
Zhou Z, Li C, Bao T, Zhao X, Xiong W, Luo C, Yin G, Fan J
Journal of neurotrauma 2022 Aug;39(15-16):1057-1074
Journal of neurotrauma 2022 Aug;39(15-16):1057-1074
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
Lam HYP, Cheng PC, Peng SY
International journal for parasitology 2022 Apr;52(5):275-284
International journal for parasitology 2022 Apr;52(5):275-284
ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.
Li L, Cui YJ, Liu Y, Li HX, Su YD, Li SN, Wang LL, Zhao YW, Wang SX, Yan F, Dong B
Cell death discovery 2022 Apr 4;8(1):161
Cell death discovery 2022 Apr 4;8(1):161
miR-142a-3p Enhances FlaA N/C Protection Against Radiation-Mediated Intestinal Injury by Modulating the IRAK1/NF-κB Signaling Pathway.
Liu T, Wu DM, Zhang F, Zhang T, He M, Zhao YY, Li J, Li L, Xu Y
International journal of radiation oncology, biology, physics 2022 Apr 1;112(5):1256-1268
International journal of radiation oncology, biology, physics 2022 Apr 1;112(5):1256-1268
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Liu H, Zhang Y, Song W, Sun Y, Jiang Y
Frontiers in cell and developmental biology 2021;9:681790
Frontiers in cell and developmental biology 2021;9:681790
Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney.
Liu W, Yang D, Shi J, Wen P, Zhang J, Wang Z, Hu B, Shi X, Cao S, Guo W, Zhang S
Frontiers in surgery 2021;8:760989
Frontiers in surgery 2021;8:760989
General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease.
Lv T, Lu Y, Liu Y, Feng H, Li C, Sheng W, Cui Z, Zhu S, Gu X, Yang Z, Wan Q
Oxidative medicine and cellular longevity 2021;2021:6691226
Oxidative medicine and cellular longevity 2021;2021:6691226
Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.
Zhu JJ, Yu BY, Huang XK, He MZ, Chen BW, Chen TT, Fang HY, Chen SQ, Fu XQ, Li PJ, Lin ZL, Zhu JH
Oxidative medicine and cellular longevity 2021;2021:6654954
Oxidative medicine and cellular longevity 2021;2021:6654954
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Bai Y, Feng Y, Jiang B, Yang Y, Pei Z, Yang Q, Cui Y
BioMed research international 2021;2021:5512518
BioMed research international 2021;2021:5512518
Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis.
Wang D, Zhan X, Wu R, You Y, Chen W, Duan L
Journal of inflammation research 2021;14:3185-3196
Journal of inflammation research 2021;14:3185-3196
Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.
Cai Y, Chai Y, Fu Y, Wang Y, Zhang Y, Zhang X, Zhu L, Miao M, Yan T
Frontiers in aging neuroscience 2021;13:809433
Frontiers in aging neuroscience 2021;13:809433
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Liu X, Xu Y, Cheng S, Zhou X, Zhou F, He P, Hu F, Zhang L, Chen Y, Jia Y
Frontiers in pharmacology 2021;12:687394
Frontiers in pharmacology 2021;12:687394
Ibudilast Attenuates Folic Acid-Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-κB and MAPK Signaling Pathways.
Li X, Zou Y, Fu YY, Xing J, Wang KY, Wan PZ, Wang M, Zhai XY
Frontiers in pharmacology 2021;12:650283
Frontiers in pharmacology 2021;12:650283
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
Zhang KK, Wang H, Qu D, Chen LJ, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xu JT, Xie XL, Li DR
Frontiers in pharmacology 2021;12:641917
Frontiers in pharmacology 2021;12:641917
JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS.
Chen L, Zhong X, Cao W, Mao M, Li W, Yang H, Li M, Shi M, Zhang Y, Deng Y, Zu X, Liu J
Frontiers in immunology 2021;12:609319
Frontiers in immunology 2021;12:609319
PRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma.
Xia T, Liu M, Zhao Q, Ouyang J, Xu P, Chen B
Cell death & disease 2021 Sep 16;12(10):851
Cell death & disease 2021 Sep 16;12(10):851
Ameliorative effects of miR-423-5p against polarization of microglial cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway.
Cheng J, Hao J, Jiang X, Ji J, Wu T, Chen X, Zhang F
International immunopharmacology 2021 Oct;99:108006
International immunopharmacology 2021 Oct;99:108006
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Tian X, Xue Y, Xie G, Zhou Y, Xiao H, Ding F, Zhang M
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Toxicology and applied pharmacology 2021 Oct 15;429:115674
The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients.
Wang Y, Li X, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z
Journal of medical virology 2021 Nov;93(11):6229-6235
Journal of medical virology 2021 Nov;93(11):6229-6235
6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy.
Luo J, Chen J, Yang C, Tan J, Zhao J, Jiang N, Zhao Y
International immunopharmacology 2021 Nov;100:108146
International immunopharmacology 2021 Nov;100:108146
The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest.
Shao R, Wang X, Xu T, Xia Y, Cui D
Journal of neuroinflammation 2021 Nov 5;18(1):257
Journal of neuroinflammation 2021 Nov 5;18(1):257
Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.
Huo S, Ren J, Ma Y, Ozathaley A, Yuan W, Ni H, Li D, Liu Z
Journal of neuroinflammation 2021 Nov 26;18(1):275
Journal of neuroinflammation 2021 Nov 26;18(1):275
c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway.
Huang Y, Wang S, Huang F, Zhang Q, Qin B, Liao L, Wang M, Wan H, Yan W, Chen D, Liu F, Jiang B, Ji D, Xia X, Huang J, Xiong K
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2021 May;235:151672
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2021 May;235:151672
Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis.
Jiang Y, Liu H, Yu H, Zhou Y, Zhang J, Xin W, Li Y, He S, Ma C, Zheng X, Zhang L, Zhao X, Wu B, Jiang C, Zhu D
Arteriosclerosis, thrombosis, and vascular biology 2021 May 5;41(5):1675-1693
Arteriosclerosis, thrombosis, and vascular biology 2021 May 5;41(5):1675-1693
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Han M, Li S, Li L
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
SET8 mitigates hepatic ischemia/reperfusion injury in mice by suppressing MARK4/NLRP3 inflammasome pathway.
Luo Y, Huang Z, Mou T, Pu J, Li T, Li Z, Yang H, Yan P, Wu Z, Wu Q
Life sciences 2021 May 15;273:119286
Life sciences 2021 May 15;273:119286
Naringenin prevents TNF-α-induced gut-vascular barrier disruption associated with inhibiting the NF-κB-mediated MLCK/p-MLC and NLRP3 pathways.
Zhong J, Yu R, Zhou Q, Liu P, Liu Z, Bian Y
Food & function 2021 Mar 21;12(6):2715-2725
Food & function 2021 Mar 21;12(6):2715-2725
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Lam HYP, Liang TR, Peng SY
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Li D, Liu M, Li Z, Zheng G, Chen A, Zhao L, Yang P, Wei L, Chen Y, Ruan XZ
Aging and disease 2021 Jun;12(3):747-763
Aging and disease 2021 Jun;12(3):747-763
FUNDC1 inhibits NLRP3-mediated inflammation after intracerebral hemorrhage by promoting mitophagy in mice.
Zheng S, Jian D, Gan H, Wang L, Zhao J, Zhai X
Neuroscience letters 2021 Jun 21;756:135967
Neuroscience letters 2021 Jun 21;756:135967
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
Li J, Qin X, Shi J, Wang X, Li T, Xu M, Chen X, Zhao Y, Han J, Piao Y, Zhang W, Qu P, Wang L, Xiang R, Shi Y
eLife 2021 Jun 11;10
eLife 2021 Jun 11;10
Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Chakravarti D, Lee R, Multani AS, Santoni A, Keith Z, Hsu WH, Chang K, Reyes L, Rashid A, Wu CJ, Li J, Zhang J, Shim HS, Chandra K, Deng P, Spring DJ, Nielsen OH, Riis LB, Mayigegowda KK, Blutt SE, Zhang J, Younes M, DuPont A, Thirumurthi S, Vilar E, Estes MK, Colla S, Shroyer NF, DePinho RA
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 20;118(29)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 20;118(29)
Sodium Sulfite-Induced Mast Cell Pyroptosis and Degranulation.
Liu M, Lu J, Chen Y, Shi X, Li Y, Yang S, Yu J, Guan S
Journal of agricultural and food chemistry 2021 Jul 14;69(27):7755-7764
Journal of agricultural and food chemistry 2021 Jul 14;69(27):7755-7764
Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway.
Wang Y, Song Y, Zhong Q, Wu Y, Zhuang J, Qu F, Xu C
International immunopharmacology 2021 Jan;90:107129
International immunopharmacology 2021 Jan;90:107129
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Wang Y, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z
Cell death & disease 2021 Jan 11;12(1):55
Cell death & disease 2021 Jan 11;12(1):55
Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy.
Meng Q, Li Y, Ji T, Chao Y, Li J, Fu Y, Wang S, Chen Q, Chen W, Huang F, Wang Y, Zhang Q, Wang X, Bian H
Journal of advanced research 2021 Feb;28:149-164
Journal of advanced research 2021 Feb;28:149-164
Inflammasome components and ADAMTS4 in premature rupture of membranes.
Zhu J, Ma C, Luan X, Li J, Peng F, Huang L
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Chen LJ, Zhi X, Zhang KK, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xie XL, Wang Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111946
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111946
An In-vivo Study into the Effects of Schisandrin B in the Liver, Spleen, Kidney, and Brain of Acute Thioacetamide-intoxicated Mice.
Lam HYP, Hung MY, Liang TR, Peng SY
Iranian journal of pharmaceutical research : IJPR 2021 Fall;20(4):300-314
Iranian journal of pharmaceutical research : IJPR 2021 Fall;20(4):300-314
Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation.
Li Z, Xu H, Xu Y, Lu G, Peng Q, Chen J, Bi R, Li J, Chen S, Li H, Jin H, Hu B
CNS neuroscience & therapeutics 2021 Dec;27(12):1570-1586
CNS neuroscience & therapeutics 2021 Dec;27(12):1570-1586
Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway.
Pu JL, Huang ZT, Luo YH, Mou T, Li TT, Li ZT, Wei XF, Wu ZJ
Hepatobiliary & pancreatic diseases international : HBPD INT 2021 Aug;20(4):352-360
Hepatobiliary & pancreatic diseases international : HBPD INT 2021 Aug;20(4):352-360
Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production.
Yang G, Song W, Xu J, Postoak JL, Cheng F, Martinez J, Zhang J, Wu L, Van Kaer L
Cellular & molecular immunology 2021 Aug;18(8):2024-2039
Cellular & molecular immunology 2021 Aug;18(8):2024-2039
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Zeng J, Tao J, Xi L, Wang Z, Liu L
International journal of molecular medicine 2021 Apr;47(4)
International journal of molecular medicine 2021 Apr;47(4)
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmáry N
Inflammation 2021 Apr;44(2):682-692
Inflammation 2021 Apr;44(2):682-692
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, Chi T, Zou L, Wang S, He Z
Oxidative medicine and cellular longevity 2020;2020:7950457
Oxidative medicine and cellular longevity 2020;2020:7950457
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R(-/-)) Mice via Its Anti-inflammatory and Antipyroptotic Effects.
Pei ZW, Guo Y, Zhu HL, Dong M, Zhang Q, Wang F
BioMed research international 2020;2020:4878704
BioMed research international 2020;2020:4878704
Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia.
He XM, Zhou YZ, Sheng S, Li JJ, Wang GQ, Zhang F
Oxidative medicine and cellular longevity 2020;2020:2963540
Oxidative medicine and cellular longevity 2020;2020:2963540
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Gao Z, Sui J, Fan R, Qu W, Dong X, Sun D
Drug design, development and therapy 2020;14:1971-1982
Drug design, development and therapy 2020;14:1971-1982
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
Li N, Zhao T, Cao Y, Zhang H, Peng L, Wang Y, Zhou X, Wang Q, Li J, Yan M, Dong X, Zhao H, Li P
Frontiers in pharmacology 2020;11:623489
Frontiers in pharmacology 2020;11:623489
NLRP6 contributes to inflammation and brain injury following intracerebral haemorrhage by activating autophagy.
Xiao H, Chen H, Jiang R, Zhang L, Wang L, Gan H, Jiang N, Zhao J, Zhai X, Liang P
Journal of molecular medicine (Berlin, Germany) 2020 Sep;98(9):1319-1331
Journal of molecular medicine (Berlin, Germany) 2020 Sep;98(9):1319-1331
FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity.
Ren J, Sun M, Zhou H, Ajoolabady A, Zhou Y, Tao J, Sowers JR, Zhang Y
Science advances 2020 Sep;6(38)
Science advances 2020 Sep;6(38)
Telomere dysfunction activates YAP1 to drive tissue inflammation.
Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA
Nature communications 2020 Sep 21;11(1):4766
Nature communications 2020 Sep 21;11(1):4766
H3 relaxin protects against calcium oxalate crystal-induced renal inflammatory pyroptosis.
Liu J, Yang K, Jin Y, Liu Y, Chen Y, Zhang X, Yu S, Song E, Chen S, Zhang J, Jing G, An R
Cell proliferation 2020 Oct;53(10):e12902
Cell proliferation 2020 Oct;53(10):e12902
Ibuprofen Exerts Antiepileptic and Neuroprotective Effects in the Rat Model of Pentylenetetrazol-Induced Epilepsy via the COX-2/NLRP3/IL-18 Pathway.
Liu R, Wu S, Guo C, Hu Z, Peng J, Guo K, Zhang X, Li J
Neurochemical research 2020 Oct;45(10):2516-2526
Neurochemical research 2020 Oct;45(10):2516-2526
Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Wu P, Chen J, Chen J, Tao J, Wu S, Xu G, Wang Z, Wei D, Yin W
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Journal of cellular physiology 2020 Oct;235(10):6582-6591
Impact of chitosan membrane culture on the expression of pro- and anti-inflammatory cytokines in mesenchymal stem cells.
Yi P, Xu X, Qiu B, Li H
Experimental and therapeutic medicine 2020 Oct;20(4):3695-3702
Experimental and therapeutic medicine 2020 Oct;20(4):3695-3702
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
Xu Y, Fang H, Xu Q, Xu C, Yang L, Huang C
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Wang Y, Zhang H, Chen Q, Jiao F, Shi C, Pei M, Lv J, Zhang H, Wang L, Gong Z
Cell proliferation 2020 Jun;53(6):e12829
Cell proliferation 2020 Jun;53(6):e12829
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
Kai J, Yang X, Wang Z, Wang F, Jia Y, Wang S, Tan S, Chen A, Shao J, Zhang F, Zhang Z, Zheng S
Free radical biology & medicine 2020 Jun;153:89-102
Free radical biology & medicine 2020 Jun;153:89-102
Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.
Jia Y, Gao L, Yang X, Zhang F, Chen A, Wang S, Shao J, Tan S, Zheng S
Toxicology 2020 Jul;440:152475
Toxicology 2020 Jul;440:152475
Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
Lam HYP, Liang TR, Jiang SJ, Peng SY
Biomolecules 2020 Jul 5;10(7)
Biomolecules 2020 Jul 5;10(7)
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.
Chang Y, Zhu J, Wang D, Li H, He Y, Liu K, Wang X, Peng Y, Pan S, Huang K
Journal of neuroinflammation 2020 Jul 23;17(1):219
Journal of neuroinflammation 2020 Jul 23;17(1):219
Autophagy Activation Represses Pyroptosis through the IL-13 and JAK1/STAT1 Pathways in a Mouse Model of Moderate Traumatic Brain Injury.
Gao C, Yan Y, Chen G, Wang T, Luo C, Zhang M, Chen X, Tao L
ACS chemical neuroscience 2020 Dec 16;11(24):4231-4239
ACS chemical neuroscience 2020 Dec 16;11(24):4231-4239
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
Lam HYP, Chen TT, Chen CC, Yang TH, Cheng PC, Peng SY
Parasitology international 2020 Aug;77:102119
Parasitology international 2020 Aug;77:102119
Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice.
Wang Q, Ou Y, Hu G, Wen C, Yue S, Chen C, Xu L, Xie J, Dai H, Xiao H, Zhang Y, Qi R
British journal of pharmacology 2020 Apr;177(8):1806-1821
British journal of pharmacology 2020 Apr;177(8):1806-1821
Histone Deacetylation 10 Alleviates Inflammation After Intracerebral Hemorrhage via the PTPN22/NLRP3 Pathway in Rats.
Wang L, Zheng S, Zhang L, Xiao H, Gan H, Chen H, Zhai X, Liang P, Zhao J, Li Y
Neuroscience 2020 Apr 15;432:247-259
Neuroscience 2020 Apr 15;432:247-259
Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release.
Tong L, Xie C, Wei Y, Qu Y, Liang H, Zhang Y, Xu T, Qian X, Qiu H, Deng H
Frontiers in oncology 2019;9:364
Frontiers in oncology 2019;9:364
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Leng B, Zhang Y, Liu X, Zhang Z, Liu Y, Wang H, Lu M
Mediators of inflammation 2019;2019:1082497
Mediators of inflammation 2019;2019:1082497
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
Dia VP, Bradwell J, Pangloli P
Plant foods for human nutrition (Dordrecht, Netherlands) 2019 Sep;74(3):307-315
Plant foods for human nutrition (Dordrecht, Netherlands) 2019 Sep;74(3):307-315
Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic E. coli infection.
Wu Z, Li Y, Liu Q, Liu Y, Chen L, Zhao H, Guo H, Zhu K, Zhou N, Chai TC, Shi B
American journal of physiology. Cell physiology 2019 Sep 1;317(3):C544-C555
American journal of physiology. Cell physiology 2019 Sep 1;317(3):C544-C555
Ameliorative effects of echinacoside against spinal cord injury via inhibiting NLRP3 inflammasome signaling pathway.
Gao S, Xu T, Guo H, Deng Q, Xun C, Liang W, Sheng W
Life sciences 2019 Nov 15;237:116978
Life sciences 2019 Nov 15;237:116978
Light-emitting diode therapy protects against ventricular arrhythmias by neuro-immune modulation in myocardial ischemia and reperfusion rat model.
Wang S, Wu L, Li X, Li B, Zhai Y, Zhao D, Jiang H
Journal of neuroinflammation 2019 Jul 8;16(1):139
Journal of neuroinflammation 2019 Jul 8;16(1):139
Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
He Q, Li Z, Meng C, Wu J, Zhao Y, Zhao J
Cells 2019 Aug 14;8(8)
Cells 2019 Aug 14;8(8)
Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells.
Zhuang J, Wang Y, Qu F, Wu Y, Zhao D, Xu C
Inflammation 2019 Apr;42(2):548-558
Inflammation 2019 Apr;42(2):548-558
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Liu H, Sun Y, Zhang Y, Yang G, Guo L, Zhao Y, Pei Z
Inflammation 2019 Apr;42(2):516-525
Inflammation 2019 Apr;42(2):516-525
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, Fan C, Guan H, Li Y, Shan Z, Teng W
Frontiers in immunology 2018;9:1197
Frontiers in immunology 2018;9:1197
Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis.
Han Y, Xu X, Tang C, Gao P, Chen X, Xiong X, Yang M, Yang S, Zhu X, Yuan S, Liu F, Xiao L, Kanwar YS, Sun L
Redox biology 2018 Jun;16:32-46
Redox biology 2018 Jun;16:32-46
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Zhang J, Tucker LD, DongYan, Lu Y, Yang L, Wu C, Li Y, Zhang Q
Neurochemistry international 2018 Jun;116:1-12
Neurochemistry international 2018 Jun;116:1-12
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
He W, Ye S, Zeng C, Xue S, Hu X, Zhang X, Gao S, Xiong Y, He X, Vivalda S, Li L, Wang Y, Ye Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
Liu Z, Zhu P, Zhang L, Xiong B, Tao J, Guan W, Li C, Chen C, Gu J, Duanmu J, Zhang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1262-1271
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1262-1271
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
Wang Y, Qin Y, Wang T, Chen Y, Lang X, Zheng J, Gao S, Chen S, Zhong X, Mu Y, Wu X, Zhang F, Zhao W, Zhong Z
Scientific reports 2018 Feb 13;8(1):2887
Scientific reports 2018 Feb 13;8(1):2887
Clostridium butyricum regulates visceral hypersensitivity of irritable bowel syndrome by inhibiting colonic mucous low grade inflammation through its action on NLRP6.
Zhao K, Yu L, Wang X, He Y, Lu B
Acta biochimica et biophysica Sinica 2018 Feb 1;50(2):216-223
Acta biochimica et biophysica Sinica 2018 Feb 1;50(2):216-223
Increased expression of NLRP3 inflammasome components and interleukin-18 in patients with bullous pemphigoid.
Fang H, Shao S, Cao T, Lei J, Dang E, Zhang J, Wang G
Journal of dermatological science 2016 Aug;83(2):116-23
Journal of dermatological science 2016 Aug;83(2):116-23
NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins.
Altaf A, Qu P, Zhao Y, Wang H, Lou D, Niu N
Coronary artery disease 2015 Aug;26(5):409-21
Coronary artery disease 2015 Aug;26(5):409-21
Schistosoma japonicum scFv-IL18 fusion DNA ameliorates hepatic fibrosis in schistosomiasis-infected mice via improving local concentration of IL-18 in liver.
Tian Z, Wang XY, Zhou YF, Feng QM, Zhang SJ, Yin TQ, Xu SR, Xia YD, Xu J, Jin J, Wang SP
Experimental parasitology 2013 Aug;134(4):447-54
Experimental parasitology 2013 Aug;134(4):447-54
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10663-1-AP(Pre-IL18 antibody) at dilution of 1:1000
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 10663-1-AP( Pre-IL18 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-Pre-IL18 (IP:10663-1-AP, 3ug; Detection:10663-1-AP 1:1000) with HeLa cells lysate 5000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human tonsillitis using 10663-1-AP(Pre-IL18 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Pre-IL18 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Pre-IL18. This antibody recognizes human antigen. The Pre-IL18 antibody has been validated for the following applications: ELISA, WB, IP, IHC analysis.
